Affinage

HLA-DRB1 literature neighborhood — HLA class II histocompatibility antigen, DRB1 beta chain

… HGNC nodes … directed cites edges … hops ← back to HLA-DRB1 record

How to read this. Each node is an HGNC-mapped partner Affinage cited in the mechanism_profile of HLA-DRB1 or, at 2-hop, of one of its partners. Edges are directed cites relations (gene → partner) and are asymmetric — A → B doesn't imply B → A. Click any node to focus it; click empty space to reset.

Literature-only. This neighborhood is built purely from partners Opus cited in the synthesis pass. It is not an interactome and does not reflect physical binding, structural interaction domains, STRING, BioGRID, or any external network database. Free-text partners that don't resolve to an HGNC symbol (complex names, aliases that didn't map, off-universe genes) are filtered out so every node is a clickable Affinage record.

hops 1 2 layout
Color = role centre gene HGNC partner with Affinage record node size ∝ n_partners

Edges come from the synthesis pass — every HGNC-mapped protein partner Opus cited for a gene becomes a directed gene → partner edge. 1-hop: the gene's own partners; 2-hop: each partner's own partners, again restricted to HGNC-mapped symbols. Source: affinage_web.db.get_neighborhood; partners come from the gene_partner projection populated by Stage 2.