Affinage

ZPR1

Zinc finger protein ZPR1 · UniProt O75312

Length
459 aa
Mass
50.9 kDa
Annotated
2026-06-11
43 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ZPR1 (ZNF259) is an essential, zinc-finger protein that couples eEF1A biogenesis to mitogenic signaling and nuclear organization (PMID:9852145, PMID:9763455, PMID:36630955). Its core biochemical activity is to act as a dedicated chaperone for the translation elongation factor eEF1A: ZPR1 binds preferentially the GDP-bound form of eEF1A through a conserved binding epitope, displaces the exchange factor eEF1Bα, and drives eEF1A into a protease-resistant folded state via a GTP-hydrolysis-dependent cycle assisted by the co-chaperone Aim29 (PMID:17704259, PMID:36630955, PMID:37597513). Loss of ZPR1 causes proteotoxic accumulation of misfolded eEF1A, eEF1A insufficiency, induction of the integrated stress response, and inhibition of protein synthesis (PMID:36630955). In quiescent cells ZPR1 is held at the cytoplasmic tyrosine kinase domain of EGFR; EGF-induced receptor tyrosine phosphorylation releases ZPR1, which redistributes with eEF1A to the nucleus, accumulates in the nucleolus, and is required for pre-rRNA expression and cell viability (PMID:8650580, PMID:9852145, PMID:9763455). During S phase ZPR1 co-localizes with SMN and the histone transcription factor NPAT in Cajal bodies, where it is required for SMN and NPAT nuclear localization, histone gene expression, and cell-cycle progression (PMID:11283611, PMID:17068332). ZPR1 regulates SMN biology directly: it binds RNA polymerase II at the SMN locus to upregulate SMN2, and maintains senataxin levels to resolve co-transcriptional R-loops and prevent DNA damage, so that ZPR1 deficiency drives SMA-like motor neuron degeneration through an MLK3→MKK7→JNK3 apoptotic cascade (PMID:31488953, PMID:31828288). A homozygous p.Ile196Thr missense mutation that abolishes ZPR1 protein causes a G1 cell-cycle defect in patient fibroblasts, establishing ZPR1 loss as a human disease determinant (PMID:29851065). ZPR1 additionally assembles by K63-ubiquitin-promoted liquid-liquid phase separation to regulate CHOP-mediated UPRER transcription (PMID:37379216).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 1996 High

    Established the first molecular handle on ZPR1 by showing it is a signaling-responsive partner of a receptor tyrosine kinase, linking growth-factor input to ZPR1 relocalization.

    Evidence Deletion mapping and co-IP showing zinc-finger binding to EGFR subdomains X/XI with phosphorylation-dependent release and nuclear accumulation

    PMID:8650580

    Open questions at the time
    • Did not identify downstream nuclear targets of released ZPR1
    • Functional consequence of EGFR binding for translation or proliferation untested
  2. 1998 High

    Identified eEF1A as a core ZPR1 partner and demonstrated the interaction is functionally essential, tying ZPR1 to translation machinery and cell-cycle progression.

    Evidence Co-IP, mutational disruption with reconstitution rescue, and cell fractionation in mammalian cells and yeast

    PMID:9763455 PMID:9852145

    Open questions at the time
    • Mechanism of how ZPR1 acts on eEF1A undefined
    • Whether the eEF1A interaction explains nucleolar/pre-rRNA requirement unresolved
  3. 2001 High

    Connected ZPR1 to the SMN pathway, showing ZPR1 is required for SMN delivery to nuclear bodies, providing a mechanistic basis for ZPR1 involvement in spinal muscular atrophy.

    Evidence Reciprocal co-IP, immunofluorescence in gems/Cajal bodies, knockdown, and SMA type I patient cell analysis

    PMID:11283611

    Open questions at the time
    • Did not establish whether ZPR1 acts on SMN transcription or trafficking
    • Mechanism of serum-stimulated co-redistribution not defined
  4. 2002 High

    Defined how ZPR1 nuclear export is controlled, showing PPIase (cyclophilin) activity and eEF1A availability govern its shuttling.

    Evidence Yeast suppressor genetics, nuclear export kinetics, and cyclophilin complementation

    PMID:12242280

    Open questions at the time
    • Direct prolyl isomerization of ZPR1 not demonstrated
    • Mammalian relevance of cyclophilin-dependent export untested
  5. 2005 High

    Demonstrated ZPR1 is essential in vivo and required for SMN/snRNP nuclear body assembly and motor neuron integrity.

    Evidence Mouse Zpr1 knockout (embryonic lethal), siRNA in motor neuron-like cells, snRNP IP, and immunofluorescence

    PMID:15767679

    Open questions at the time
    • Molecular cause of apoptosis not yet defined
    • Tissue-specific requirements not dissected
  6. 2006 High

    Linked ZPR1 to S-phase histone gene transcription and confirmed its in vivo role in neurodegeneration.

    Evidence Cell-cycle synchronization with NPAT/Cajal body colocalization, histone RT-PCR, and Zpr1-reduced mouse spinal cord histopathology

    PMID:16648254 PMID:17068332

    Open questions at the time
    • Direct ZPR1 occupancy at histone loci not shown
    • Connection between histone transcription role and neurodegeneration unclear
  7. 2007 High

    Provided structural and biochemical mechanism for the ZPR1–eEF1A interaction, defining ZPR1 as a regulator of eEF1A nucleotide state.

    Evidence Crystal structure of ZPR1 domain tandem, binding assays showing GDP-eEF1A preference and eEF1Bα displacement, and structure-guided mutagenesis with complementation

    PMID:17704259

    Open questions at the time
    • Cellular consequence of eEF1Bα displacement not directly measured
    • Did not yet identify the chaperone activity later described
  8. 2009 Medium

    Mapped a regulatory region (residues 193–246) that confers Zn2+-dependence on the ZPR1–eEF1A interaction.

    Evidence Deletion mutant (ΔA) co-IP showing constitutive, Zn2+-independent eEF1A binding

    PMID:19966453

    Open questions at the time
    • Single co-IP approach without orthogonal validation
    • Structural basis of Zn2+ regulation not resolved
  9. 2012 Medium

    Placed ZPR1 within receptor tyrosine kinase developmental signaling in an organismal context, downstream of EGFR/FGFR.

    Evidence Drosophila genetic mosaic screen and epistasis for tracheal lumen formation, with Smn phenocopy

    PMID:23029159

    Open questions at the time
    • Molecular target of ZPR1 in lumen formation unknown
    • Relationship to translation/eEF1A role not addressed
  10. 2017 High

    Identified HoxA5 as a ZPR1-dependent transcriptional output critical for motor neuron function, linking ZPR1/SMN to respiratory phenotypes.

    Evidence Motor neuron-specific conditional Zpr1 knockout in mice with HoxA5 expression analysis and respiratory assays

    PMID:28811488

    Open questions at the time
    • Whether ZPR1 regulates HoxA5 directly or via SMN unclear
    • Mechanism connecting HoxA5 to phrenic neuron survival not defined
  11. 2018 Medium

    Revealed ZPR1 loss causes a human cell-cycle disease phenotype and that ZPR1 modulates oncogenic signaling, broadening its physiological scope.

    Evidence Patient exome (p.Ile196Thr, protein loss, G1 arrest) and ERK/GSK3β/Snail pathway manipulation in breast cancer cells with inhibitor rescue

    PMID:29851065 PMID:30214308

    Open questions at the time
    • Disease entity caused by the mutation not fully characterized
    • Direct vs indirect effect on ERK/Snail signaling not resolved
  12. 2019 High

    Defined the apoptotic effector pathway of ZPR1 deficiency (JNK3) and an additional tumor-suppressive signaling context (FAK-AKT).

    Evidence Jnk3-null genetic rescue plus pharmacological JNK inhibition for neurodegeneration; siRNA with FAK/AKT inhibitor rescue in lung cancer cells

    PMID:29276408 PMID:31488953

    Open questions at the time
    • Upstream trigger linking ZPR1 loss to MLK3 activation unknown
    • Whether translation defects drive JNK3 activation untested
  13. 2020 High

    Established a direct gene-regulatory mechanism by which ZPR1 upregulates SMN2 and protects the genome from R-loop-driven damage via senataxin.

    Evidence RNA Pol II co-IP, ChIP at the SMN locus, in vivo transgenic overexpression rescue of SMA, S9.6 R-loop and DNA damage assays, and senataxin quantification

    PMID:31828288

    Open questions at the time
    • Mechanism by which ZPR1 maintains senataxin levels unresolved
    • Whether transcriptional and chaperone functions are mechanistically linked unclear
  14. 2023 High

    Resolved the molecular function of ZPR1 as a bespoke eEF1A folding chaperone operating through a GTP-hydrolysis cycle with co-chaperone Aim29.

    Evidence Two independent biochemical reconstitutions, protease-protection assays, GTPase assays, ColabFold modeling, and yeast genetics

    PMID:36630955 PMID:37597513

    Open questions at the time
    • High-resolution structure of the ZPR1·eEF1A·Aim29 folding intermediate lacking
    • Human Aim29 ortholog and in-cell coupling to disease phenotypes not established
  15. 2023 Medium

    Added a phase-separation-based regulatory mode, linking ZPR1 ubiquitin recognition to ER stress transcription and host-pathogen control.

    Evidence Proximity crosslinking, in vitro LLPS and K63-ubiquitin binding assays, CHOP reporter, and bacterial NleE effector disruption

    PMID:37379216

    Open questions at the time
    • Physiological trigger of ZPR1 LLPS in cells unconfirmed
    • Relationship between LLPS and the eEF1A chaperone function unknown
  16. 2025 Medium

    Refined the R-loop role, showing ZPR1 regulates host versus viral R-loop dynamics differentially via a SETX-containing complex.

    Evidence E2-ZPR1-SETX co-IP, siRNA depletion, S9.6 R-loop detection, and SETX ChIP at the HPV promoter

    PMID:41305523

    Open questions at the time
    • Single study with siRNA depletion
    • Mechanism distinguishing host vs viral R-loop regulation unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • How ZPR1's distinct activities — cytoplasmic eEF1A chaperoning, nuclear SMN/SMN2 regulation, R-loop resolution, and phase separation — are coordinated within a single protein remains unresolved.
  • No unified model integrating chaperone and transcriptional/genome-protective roles
  • Mechanism of signal-dependent partitioning between functions unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 2 GO:0044183 protein folding chaperone 2 GO:0140110 transcription regulator activity 2 GO:0098772 molecular function regulator activity 1
Localization
GO:0005634 nucleus 3 GO:0005654 nucleoplasm 2 GO:0005829 cytosol 2 GO:0005730 nucleolus 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1640170 Cell Cycle 2 R-HSA-392499 Metabolism of proteins 2 R-HSA-74160 Gene expression (Transcription) 2 R-HSA-8953897 Cellular responses to stimuli 2 R-HSA-73894 DNA Repair 1
Partners
AIM29EEF1A1EEF1BEGFRNPATSETXSMN1
Complex memberships
Cajal bodyZPR1·eEF1A·Aim29 folding complex

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 ZPR1 binds to the cytoplasmic tyrosine kinase domain of the epidermal growth factor receptor (EGFR) via its zinc fingers interacting with subdomains X and XI of the EGFR tyrosine kinase; EGF treatment causes decreased ZPR1-EGFR binding in a tyrosine phosphorylation-dependent manner, releasing ZPR1 to accumulate in the nucleus. Deletion analysis, co-immunoprecipitation, cell fractionation Science High 8650580
1998 ZPR1 binds to eukaryotic translation elongation factor-1alpha (eEF-1alpha); EGF treatment induces this interaction and the co-redistribution of both proteins to the nucleus. In yeast, disruption of the ZPR1-eEF-1alpha interaction by mutation causes G2/M accumulation and defective growth, which is rescued by reconstituting the interaction. Co-immunoprecipitation, mutational analysis, genetic complementation, cell fractionation, yeast growth assays The Journal of cell biology High 9852145
1998 ZPR1 accumulates in the nucleolus of proliferating cells; ZPR1 gene disruption causes loss of nucleolar function including disruption of pre-ribosomal RNA expression, and cells lacking ZPR1 are not viable. Gene disruption (knockout), subcellular fractionation, fluorescence microscopy, pre-rRNA expression analysis Molecular biology of the cell High 9763455
2001 ZPR1 interacts with the SMN protein and both proteins co-localize in subnuclear structures including gems and Cajal bodies; serum stimulation causes redistribution of SMN and ZPR1 from cytoplasm to nucleus, a process disrupted in SMA type I patient cells with SMN1 mutations. Decreased ZPR1 expression prevents SMN localization to nuclear bodies. Co-immunoprecipitation, fluorescence microscopy, siRNA/antisense knockdown, patient cell analysis Nature cell biology High 11283611
2002 Cyclophilin A (Cpr1p) PPIase activity is required for nuclear export of Zpr1p in yeast; in cpr1Δ cells or with CPR1-dependent ZPR1 mutant alleles, Zpr1p accumulates in the nucleus due to defective export. PPIase activity of cyclophilins and structurally unrelated PPIase Fpr1p can suppress this defect, and overexpression of EF1alpha (a Zpr1p binding partner) also suppresses it. Yeast genetics (suppressor screen), nuclear export kinetic studies, fluorescence microscopy, mutant cyclophilin complementation Molecular and cellular biology High 12242280
2005 Targeted ablation of Zpr1 in mice disrupts subcellular localization of SMN to Cajal bodies and gems, and reduces cytoplasmic snRNP levels. Zpr1-/- mice die during early embryonic development with reduced proliferation and increased apoptosis. In motor neuron-like cells, siRNA-mediated ZPR1 depletion causes growth cone retraction, axonal defects, and apoptosis. Conditional gene knockout (mouse), siRNA knockdown, immunofluorescence microscopy, snRNP immunoprecipitation Molecular and cellular biology High 15767679
2006 ZPR1 redistributes to the nucleus during S phase and co-localizes with SMN and the histone transcription factor NPAT at Cajal bodies associated with histone gene clusters. ZPR1 deficiency disrupts SMN and NPAT nuclear localization, blocks S-phase progression, arrests cells in G1 and G2 phases, and decreases histone gene expression. Cell cycle synchronization, fluorescence microscopy, siRNA knockdown, flow cytometry, RT-PCR for histone gene expression The Journal of biological chemistry High 17068332
2006 ZPR1-deficient mice (heterozygous Zpr1 reduction) exhibit axonal pathology and neurodegeneration, identifying ZPR1 deficiency as a contributing factor in neurodegenerative disorders. Mouse model with targeted Zpr1 gene ablation, histopathological analysis of spinal cord Proceedings of the National Academy of Sciences of the United States of America Medium 16648254
2007 Crystal structure of the ZPR1 domain tandem revealed that each ZPR1 domain consists of an EIF2-like zinc finger and a double-stranded beta helix with a helical hairpin insertion. ZPR1 binds preferentially to GDP-bound eEF1A, does not directly influence nucleotide exchange kinetics or GTP hydrolysis, but efficiently displaces the exchange factor eEF1Bα from preformed nucleotide-free complexes, suggesting a role as a negative regulator of eEF1A activation. Structure-based mutagenesis identified a conserved eEF1A binding epitope required for normal cell growth, proliferation, and cell cycle progression. X-ray crystallography, biochemical binding assays, structure-based mutagenesis, complementation assays Proceedings of the National Academy of Sciences of the United States of America High 17704259
2009 A ZPR1 deletion mutant (ΔA, Δ193-246) binds eEF1alpha constitutively and independently of Zn2+ in vivo, defining a region that normally controls the Zn2+-dependence of the ZPR1-eEF1alpha interaction. Mutational analysis, co-immunoprecipitation in vivo Bioscience, biotechnology, and biochemistry Medium 19966453
2012 In Drosophila, Zpr1 is required downstream of both EGFR and FGFR signaling for tracheal subcellular lumen formation; Zpr1 mutations block lumen maturation, EGFR down-regulation phenocopies Zpr1 mutation, and Zpr1 is epistatic to EGFR overexpression-driven lumen formation. Reduction of Smn (a ZPR1-interacting protein) produces similar defects. Forward genetic mosaic screen, genetic epistasis analysis, RNAi knockdown in Drosophila PloS one Medium 23029159
2017 ZPR1 functions downstream of SMN to regulate HoxA5 levels in phrenic motor neurons; spatiotemporal inactivation of Zpr1 in motor neurons down-regulates HoxA5 and causes defects in phrenic motor neuron function resulting in respiratory failure and perinatal lethality in mice. Modulation of ZPR1 levels directly correlates with HoxA5 transcription levels in SMA mice. Conditional motor neuron-specific Zpr1 knockout (mouse), quantitative gene expression analysis, respiratory function assays Scientific reports High 28811488
2018 ZNF259/ZPR1 promotes breast cancer cell invasion and migration by activating the ERK/GSK3β/Snail signaling pathway; ZNF259 knockdown reduces p-ERK, p-GSK3β, and Snail and upregulates E-cadherin/ZO-1, while ZNF259 overexpression has the opposite effects. ERK inhibitor U0126 reverses effects of ZNF259 overexpression. siRNA knockdown, plasmid overexpression, Western blotting, Matrigel invasion assay, wound healing assay, pharmacological inhibition Cancer management and research Medium 30214308
2018 A homozygous missense mutation in ZPR1 (p.Ile196Thr) causes complete loss of ZPR1 protein in patient fibroblasts and a cell cycle defect with a significant number of cells arrested in G1 phase; structural modeling indicates this mutation disrupts the hydrophobic core of ZPR1. Exome sequencing, Western blot (no detectable ZPR1 protein), flow cytometry cell cycle analysis, structural modeling Clinical genetics Medium 29851065
2019 ZPR1-dependent neurodegeneration is mediated by the JNK signaling pathway, specifically through CNS-specific JNK3; ZPR1 deficiency activates the MLK3→MKK7→JNK3 cascade, phosphorylates c-Jun, and activates caspase-mediated neuron degeneration. Neurons from Jnk3-null mice are resistant to ZPR1-dependent neurodegeneration, and pharmacologic JNK inhibition reduces degeneration. Mouse genetic models (Jnk3 knockout, Zpr1-deficient), pharmacological JNK inhibition, Western blotting for signaling intermediates, apoptosis assays Journal of experimental neuroscience High 31488953
2019 ZNF259/ZPR1 depletion in lung cancer cells leads to enhanced p-FAK and p-AKT, CyclinD1, and MMP2 levels, increasing proliferation and invasion; effects are reversed by specific FAK or AKT inhibitors, placing ZNF259 upstream of the FAK-AKT pathway as an inhibitor. siRNA knockdown, Western blotting, invasion and proliferation assays, pharmacological inhibition Cancer management and research Medium 29276408
2020 ZPR1 binds to RNA polymerase II and interacts in vivo with the SMN locus to upregulate SMN2 expression; ZPR1 overexpression in vivo increases SMN levels systemically and rescues severe SMA in mice. Low ZPR1 levels cause accumulation of co-transcriptional R-loops and DNA damage; ZPR1 complementation elevates senataxin levels, reduces R-loop accumulation and rescues DNA damage in SMA mice, motor neurons, and patient cells. Co-immunoprecipitation with RNA Pol II, chromatin immunoprecipitation (ChIP) at SMN locus, in vivo transgenic overexpression, R-loop detection assays (S9.6 antibody), DNA damage assays, senataxin protein quantification Brain High 31828288
2023 Zpr1 is a bespoke chaperone dedicated to eEF1A biogenesis; Zpr1 depletion causes acute proteotoxicity from misfolded eEF1A biosynthesis, and prolonged depletion causes eEF1A insufficiency inducing the integrated stress response and inhibiting protein synthesis. Biochemical reconstitution demonstrated that Zpr1 enables eEF1A to achieve a protease-resistant conformational state. ColabFold structural modeling revealed that Zpr1's zinc-finger and alpha-helical hairpin structures mediate the folding mechanism. Biochemical reconstitution (two approaches), protease protection assay, structural modeling (ColabFold), yeast genetic depletion, polysome profiling Molecular cell High 36630955
2023 Folding of eEF1A by Zpr1 requires GTP hydrolysis by eEF1A. The conserved protein Aim29 acts as a Zpr1 co-chaperone that recognizes eEF1A in the GTP-bound pre-hydrolysis conformation, dampens Zpr1·eEF1A GTPase activity, and facilitates client exit from the folding cycle. Biochemical reconstitution, GTPase activity assays, yeast genetics, fluorescence microscopy, structural modeling Molecular cell High 37597513
2023 ZPR1 assembles via liquid-liquid phase separation (LLPS) in vitro and regulates CHOP-mediated UPRER at the transcriptional level. ZPR1 binding to K63-ubiquitin chains promotes its LLPS. The bacterial effector NleE (from EPEC) disrupts ZPR1 binding to K63-ubiquitin chains, thereby inhibiting ZPR1 LLPS and suppressing host UPRER. Proximity-enabled protein crosslinking (to identify interaction), in vitro LLPS assay, ubiquitin chain binding assay, CHOP transcription reporter assay Cell reports Medium 37379216
2025 ZPR1 depletion decreased viral (HPV) R-loops while enhancing cellular R-loops, and increased SETX binding to the viral promoter. E2-ZPR1-SETX complex was detected. ZPR1 is thus not required for HPV R-loop resolution but regulates host R-loop dynamics, in contrast to its previously described role in resolving R-loops in mammalian cells. Co-immunoprecipitation (E2-SETX-ZPR1 complex), siRNA depletion, R-loop detection (S9.6), ChIP for SETX at viral promoter Viruses Medium 41305523

Source papers

Stage 0 corpus · 43 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2001 Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein. Nature cell biology 117 11283611
1996 Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor. Science (New York, N.Y.) 102 8650580
1998 Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells. The Journal of cell biology 93 9852145
1998 The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells. Molecular biology of the cell 73 9763455
2005 ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies. Molecular and cellular biology 62 15767679
2002 Cyclophilin A peptidyl-prolyl isomerase activity promotes ZPR1 nuclear export. Molecular and cellular biology 57 12242280
2012 The zinc finger protein ZPR1 is a potential modifier of spinal muscular atrophy. Human molecular genetics 56 22422766
2020 ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy. Brain : a journal of neurology 53 31828288
2016 Two-stage association study to identify the genetic susceptibility of a novel common variant of rs2075290 in ZPR1 to type 2 diabetes. Scientific reports 46 27411854
2006 Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression. The Journal of biological chemistry 46 17068332
2006 Deficiency of the zinc finger protein ZPR1 causes neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America 43 16648254
2007 Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes. Proceedings of the National Academy of Sciences of the United States of America 41 17704259
2014 Association of the variants in the BUD13-ZNF259 genes and the risk of hyperlipidaemia. Journal of cellular and molecular medicine 38 24780069
2015 Association of FURIN and ZPR1 polymorphisms with metabolic syndrome. Biomedical reports 31 26405538
2015 Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population. PloS one 20 26397108
2017 Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal. PloS one 18 28245265
2018 ZNF259 promotes breast cancer cells invasion and migration via ERK/GSK3β/snail signaling. Cancer management and research 17 30214308
2017 Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy. Scientific reports 16 28811488
2023 Zinc-finger protein Zpr1 is a bespoke chaperone essential for eEF1A biogenesis. Molecular cell 15 36630955
2019 Association of BUD13-ZNF259-APOA5-APOA1-SIK3 cluster polymorphism in 11q23.3 and structure of APOA5 with increased plasma triglyceride levels in a Korean population. Scientific reports 15 31165758
2017 Solanum tuberosum ZPR1 encodes a light-regulated nuclear DNA-binding protein adjusting the circadian expression of StBBX24 to light cycle. Plant, cell & environment 15 27928822
2019 ZPR1-Dependent Neurodegeneration Is Mediated by the JNK Signaling Pathway. Journal of experimental neuroscience 14 31488953
2021 Kernel machine SNP set analysis finds the association of BUD13, ZPR1, and APOA5 variants with metabolic syndrome in Tehran Cardio-metabolic Genetics Study. Scientific reports 13 33986338
2014 Association of a genetic variant of the ZPR1 zinc finger gene with type 2 diabetes mellitus. Biomedical reports 13 25469254
2019 Functional polymorphisms of the APOA1/C3/A4/A5-ZPR1-BUD13 gene cluster are associated with dyslipidemia in a sex-specific pattern. PeerJ 12 30631647
2017 ZNF259 inhibits non-small cell lung cancer cells proliferation and invasion by FAK-AKT signaling. Cancer management and research 12 29276408
2015 Zinc Finger Protein 259 (ZNF259) Polymorphisms are Associated with the Risk of Metabolic Syndrome in a Han Chinese Population. Clinical laboratory 10 26118197
2023 Bacterial effector restricts liquid-liquid phase separation of ZPR1 to antagonize host UPRER. Cell reports 8 37379216
2019 Interaction of polymorphisms in APOA4-APOA5-ZPR1-BUD13 gene cluster and sleep duration on 5-year lipid changes in middle aged and older Chinese. Sleep 8 31181149
2018 A ZPR1 mutation is associated with a novel syndrome of growth restriction, distinct craniofacial features, alopecia, and hypoplastic kidneys. Clinical genetics 8 29851065
2015 Association study of BUD13-ZNF259 gene rs964184 polymorphism and hemorrhagic stroke risk. International journal of clinical and experimental medicine 8 26885234
2020 The ZPR1 genotype predicts myocardial infarction in patients with familial hypercholesterolemia. Journal of clinical lipidology 7 32807694
2012 Drosophila Zpr1 (Zinc finger protein 1) is required downstream of both EGFR and FGFR signaling in tracheal subcellular lumen formation. PloS one 7 23029159
2006 Expression of zinc finger protein ZPR1 mRNA in brain is up-regulated in mice fed a high-fat diet. International journal of molecular medicine 7 16465397
2019 There is an association between a genetic polymorphism in the ZNF259 gene involved in lipid metabolism and coronary artery disease. Gene 6 30902787
2022 A Gene Variation at the ZPR1 Locus (rs964184) Interacts With the Type of Diet to Modulate Postprandial Triglycerides in Patients With Coronary Artery Disease: From the Coronary Diet Intervention With Olive Oil and Cardiovascular Prevention Study. Frontiers in nutrition 5 35782928
2023 A Zpr1 co-chaperone mediates folding of eukaryotic translation elongation factor 1A via a GTPase cycle. Molecular cell 4 37597513
2023 ZPR1 is an immunodiagnostic biomarker and promotes tumor progression in esophageal squamous cell carcinoma. Cancer science 4 37964506
2021 High-fat diet-associated cognitive decline: Is zinc finger protein 1 (ZPR1) the molecular connection? Current research in physiology 4 34746842
2019 Polymorphisms in genes that affect the variation of lipid levels in a Brazilian pediatric population with sickle cell disease: rs662799 APOA5 and rs964184 ZPR1. Blood cells, molecules & diseases 4 31670185
2009 Generation of a zinc finger protein ZPR1 mutant that constitutively interacted with translation elongation factor 1alpha. Bioscience, biotechnology, and biochemistry 2 19966453
2025 Genome-wide study links cardiometabolic factors to cognition via APOA4-APOA5-ZPR1-BUD13 and other loci in rural Indians. Alzheimer's & dementia : the journal of the Alzheimer's Association 1 40665476
2025 ZPR1 Is Dispensable for HPV R-Loop Resolution but Regulates Host R-Loop Dynamics. Viruses 0 41305523

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