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Showing SLC30A7 — ZNT7 is a alias.

SLC30A7

Zinc transporter 7 · UniProt Q8NEW0

Length
376 aa
Mass
41.6 kDa
Annotated
2026-06-10
30 papers in source corpus 24 papers cited in narrative 24 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC30A7 (ZnT7) is a Golgi-localized Zn2+/H+ antiporter that supplies cytoplasmic zinc to the secretory pathway and thereby supports the activation of zinc-dependent metalloenzymes and broad zinc-homeostatic functions in the cell (PMID:12446736, PMID:37553324). Cryo-EM structures resolve ZnT7 as a homodimer in which each protomer carries a single transmembrane Zn2+-binding site and cycles between inward- and outward-facing conformations, while an unusually long cytosolic histidine-rich loop binds Zn2+ and recruits it to the transmembrane transport pathway (PMID:37553324). Within the Golgi, ZnT7 (acting alongside ZnT5) loads zinc into alkaline phosphatases to generate active holo-enzyme (PMID:15525635) and supplies Zn2+ to Golgi α-mannosidase II to support N-glycan maturation (PMID:38762179). Systemically, ZnT7 drives dietary zinc absorption and whole-body zinc accumulation (PMID:17954933), promotes insulin gene transcription in pancreatic β-cells via the metal-responsive transcription factor Mtf1 (PMID:20599947), and is required—together with ZnT8—for glucose-stimulated insulin secretion (PMID:27754787), while in skeletal muscle it sustains insulin signaling and lipid handling, its loss producing glucose intolerance, insulin resistance, and intracellular lipid accumulation (PMID:22854958, PMID:29555680). ZnT7 deficiency repeatedly engages stress and survival signaling, modulating PI3K/Akt and MAPK/ERK pathways and apoptosis across multiple cell types (PMID:23403124, PMID:32949653), and ERK1 phosphorylation of ZnT7 at T297 enhances Golgi zinc loading to drive MMP-mediated β-catenin oncogenic signaling (PMID:42190790). Compound heterozygous loss-of-function variants in SLC30A7 cause Ziegler-Huang Syndrome (bone marrow failure, growth retardation, testicular hypoplasia), associated with impaired AKT activation and elevated TP53 (PMID:36821639, PMID:40286389).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2002 High

    Established the core identity of ZnT7 by showing it resides in the Golgi and moves cytoplasmic zinc into the Golgi lumen, defining its directionality and compartment.

    Evidence Immunofluorescence and zinc accumulation assays in transfected CHO cells

    PMID:12446736

    Open questions at the time
    • Transport mechanism and stoichiometry not defined
    • No evidence of physiological substrate enzymes yet
  2. 2004 High

    Connected ZnT7 transport activity to a functional output by demonstrating it loads zinc into secretory-pathway alkaline phosphatases, converting apo- to holo-enzyme.

    Evidence Gene disruption in DT40 cells with ALP activity assay and re-expression rescue

    PMID:15525635

    Open questions at the time
    • Redundancy with ZnT5 leaves individual contributions partly unresolved
    • Other Golgi metalloenzyme clients not yet tested
  3. 2007 High

    Defined the systemic role of ZnT7 in dietary zinc absorption and whole-body zinc status using a knockout mouse, showing growth effects not rescuable by dietary zinc.

    Evidence Gene-trap knockout mouse with tissue/cell zinc measurements and radioactive zinc feeding

    PMID:17954933

    Open questions at the time
    • Cell-autonomous versus systemic basis of growth defect unresolved
    • Molecular link between Golgi zinc loading and absorption not established
  4. 2010 Medium

    Linked ZnT7 to insulin biology by showing it raises insulin gene transcription through Mtf1 acting on metal-responsive elements, implicating zinc-driven gene regulation.

    Evidence Overexpression in RIN5mF cells with RT-PCR, metabolic labeling, and Mtf1/MRE binding analysis

    PMID:20599947

    Open questions at the time
    • Single overexpression system, no loss-of-function confirmation
    • Direct demonstration of Golgi zinc gradient driving Mtf1 lacking
  5. 2012 High

    Extended ZnT7 function to peripheral insulin action, showing skeletal-muscle ZnT7 supports the Insr/Irs2/Akt axis and glucose uptake.

    Evidence Znt7-KO mice with metabolic phenotyping plus gain-of-function in L6 muscle cells

    PMID:22854958

    Open questions at the time
    • Mechanistic link between Golgi zinc and Akt signaling not defined
    • Whether effect is direct or secondary to lipid changes unresolved
  6. 2016 High

    Resolved genetic redundancy in β-cell secretion by showing combined ZnT7/ZnT8 deletion abolishes glucose-stimulated insulin secretion while ZnT7 alone impairs glucose tolerance and islet composition.

    Evidence Single and double knockout mice with islet GSIS, insulin content, and morphology analysis

    PMID:27754787

    Open questions at the time
    • Molecular basis of ZnT7/ZnT8 functional overlap unclear
    • Cause of altered α-to-β cell ratio not established
  7. 2018 High

    Defined the mechanism of muscle insulin resistance in ZnT7 loss as lipid-driven, linking zinc dyshomeostasis to fatty-acid accumulation and bioactive lipid mediators.

    Evidence znt7-KO mice with lipidomics, oxylipin profiling, EM, and molecular analysis

    PMID:29555680

    Open questions at the time
    • Causal chain from Golgi zinc to lipid transporter upregulation unresolved
    • Which zinc-dependent enzyme drives lipid phenotype unknown
  8. 2018 Medium

    Implicated ZnT7 in cytoprotection and disease signaling across tissues, modulating PI3K/Akt, MAPK/ERK, and TGF-β/Smad pathways in osteoblasts and renal cells.

    Evidence Reciprocal overexpression/knockdown with apoptosis and EMT readouts in MC3T3-E1, NRK-52E, and cardiomyocyte models

    PMID:23403124 PMID:29307859 PMID:29627824

    Open questions at the time
    • Single-lab cell-line studies, in vivo confirmation limited
    • Direct molecular target connecting ZnT7 to these pathways not identified
  9. 2017 Medium

    Identified a physical interaction between ZnT7 and CD40, placing ZnT7 in immune receptor signaling in B cells.

    Evidence Immunoprecipitation with flow cytometry and p38 MAPK phosphorylation readouts under knockdown/overexpression

    PMID:28469980

    Open questions at the time
    • Single Co-IP without reciprocal structural validation
    • Mechanism by which ZnT7 controls CD40 surface expression unknown
  10. 2023 High

    Provided the structural mechanism, revealing ZnT7 as a homodimeric Zn2+/H+ antiporter with an alternating-access cycle and a histidine-rich loop that recruits zinc to the transport path.

    Evidence Cryo-EM structures at 2.2–3.1 Å in Zn2+-bound and unbound states

    PMID:37553324

    Open questions at the time
    • Proton coupling stoichiometry not quantified
    • Regulatory inputs onto the histidine-rich loop in vivo not addressed
  11. 2023 Medium

    Established the genetic link to human disease, identifying compound heterozygous loss-of-function SLC30A7 variants causing Ziegler-Huang Syndrome.

    Evidence Exome sequencing, RNA-seq splicing analysis, and patient-cell protein quantification

    PMID:36821639

    Open questions at the time
    • Single family/lab, genotype-phenotype breadth unknown
    • Mechanism connecting ZnT7 loss to bone marrow failure not yet defined here
  12. 2024 High

    Identified Golgi α-mannosidase II as a ZnT7 client enzyme, mechanistically linking ZnT7 to N-glycan maturation with specificity confirmed against lysosomal mannosidase.

    Evidence Genetic disruption of ZNT5-6/ZNT7 with GMII activity assay, N-glycan profiling, and xenograft validation

    PMID:38762179

    Open questions at the time
    • Full repertoire of Golgi metalloenzyme clients incomplete
    • Contribution of glycosylation defect to organismal phenotypes unquantified
  13. 2025 Medium

    Connected human ZnT7 loss to the AKT/TP53 axis and hematopoiesis, with wild-type rescue restoring insulin-stimulated AKT and KO mice modeling cytopenia.

    Evidence Patient-cell Western blots, wild-type ZNT7 transduction rescue, bone marrow lineage co-expression, and Znt7-KO hematology

    PMID:40286389

    Open questions at the time
    • Mechanism linking Golgi zinc to TP53 elevation unresolved
    • Single-lab model of bone marrow failure
  14. 2026 Medium

    Defined a post-translational regulatory axis, showing ERK1 phosphorylates ZnT7 at T297 to enhance Golgi zinc loading and drive MMP/β-catenin oncogenic signaling.

    Evidence Mouse 4NQO tumorigenesis KO, phosphosite mapping, ZNG1 Co-IP, MMP and β-catenin pathway assays, PDX model

    PMID:42190790

    Open questions at the time
    • Single lab, awaiting independent replication
    • Direct structural basis of T297 phosphorylation effect on transport not shown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single Golgi zinc-loading transporter mechanistically dictates such diverse outcomes—glycosylation, insulin secretion, lipid metabolism, hematopoiesis, and oncogenic signaling—remains unresolved.
  • No unifying model linking compartmental zinc gradients to downstream signaling pathways
  • Tissue-specific client enzyme repertoires undefined
  • In vivo significance of mitochondrial/SER ZnT7 pools relative to Golgi pool unclear

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 4 GO:0140104 molecular carrier activity 2 GO:0016787 hydrolase activity 1
Localization
GO:0005794 Golgi apparatus 5 GO:0005739 mitochondrion 2 GO:0005783 endoplasmic reticulum 1 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-382551 Transport of small molecules 3 R-HSA-1430728 Metabolism 2 R-HSA-392499 Metabolism of proteins 2
Partners
CD40ERK1SLC30A5ZNG1

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 ZnT7 is localized in the Golgi apparatus and cytoplasmic vesicles, and facilitates zinc transport from the cytoplasm into the Golgi apparatus; exposure of ZnT7-expressing CHO cells to zinc causes zinc accumulation in the Golgi apparatus. Immunofluorescence microscopy, zinc accumulation assay in transfected CHO cells, Western blot The Journal of biological chemistry High 12446736
2004 ZnT7 (together with ZnT5) is required for loading zinc into alkaline phosphatases (ALPs) in the secretory pathway, converting apo-ALP to holo-ALP; double knockout of ZnT5 and ZnT7 in DT40 cells reduced ALP activity to <5% of wild-type, and re-expression of either ZnT5 or ZnT7 rescued activity. Gene disruption in DT40 cells, ALP activity assay, overexpression rescue experiment The Journal of biological chemistry High 15525635
2007 Znt7-deficient mice are zinc-deficient (reduced zinc in serum, liver, bone, kidney, small intestine; ~50% cellular zinc in embryonic fibroblasts), show reduced dietary zinc absorption, and display reduced body fat accumulation; the growth defect cannot be corrected by dietary zinc supplementation. Gene-trap knockout mouse model, zinc content measurement in tissues and cells, radioactive zinc feeding study The Journal of biological chemistry High 17954933
2009 ZnT7 is localized to the Golgi apparatus membrane in Purkinje cells, Bergmann glial cells, and granule cells of the mouse cerebellum, as confirmed by co-localization with the trans-Golgi marker TGN38 and immuno-electron microscopy. Immunofluorescence confocal microscopy, immuno-electron microscopy, Western blot Histology and histopathology Medium 19283665
2009 ZnT7 is localized to the Golgi apparatus in spermatocytes, spermatids, Sertoli cells, and Leydig cells of the mouse testis, co-localizing with the trans-Golgi marker TGN38; ZnT7 and chelatable zinc are distributed in different cell populations in the testis. Immunohistochemistry, double immunofluorescence with TGN38, zinc autometallographic staining Histology and histopathology Medium 19012241
2010 Overexpression of ZnT7 in RIN5mF pancreatic beta-cells increases insulin mRNA expression, insulin protein synthesis, and total cellular insulin content; this effect is mediated through metal-responsive transcription factor Mtf1 binding to metal-responsive elements (MREs) in the Ins1 and Ins2 gene promoters. Overexpression in RIN5mF cells, quantitative RT-PCR, 35S metabolic labeling, promoter MRE identification, Mtf1 binding assay Experimental cell research Medium 20599947
2011 Znt7-null mutation in a TRAMP prostate cancer mouse model accelerates prostate tumor formation, increases frequency of high-grade PIN, promotes metastasis to lymph nodes, and reduces apoptosis in the prostate. TRAMP/Znt7-/- transgenic mouse model, histopathological analysis, apoptosis measurement Cancer letters Medium 21621325
2012 ZnT7 in skeletal muscle supports insulin signaling; Znt7-KO mice fed a high-fat diet develop glucose intolerance and insulin resistance associated with down-regulated Insr, Irs2, and Akt1 mRNA in skeletal muscle; overexpression of ZnT7 in L6 skeletal muscle cells increased Irs2 mRNA, Irs2 and Akt phosphorylation, and glucose uptake. Znt7-KO mouse model, high-fat diet challenge, oral glucose tolerance test, insulin tolerance test, overexpression in L6 cells, quantitative RT-PCR, Western blot, glucose uptake assay The Journal of biological chemistry High 22854958
2013 ZnT7 overexpression protects MC3T3-E1 osteoblasts from H2O2-induced apoptosis by reducing intracellular free zinc accumulation; this protective effect is mediated through activation of PI3K/Akt and MAPK/ERK signaling pathways; ZnT7 siRNA knockdown exacerbates apoptosis. Overexpression and siRNA knockdown in MC3T3-E1 cells, H2O2 treatment, apoptosis assay, Western blot for pathway activation Cellular signalling Medium 23403124
2016 Combined deletion of Slc30a7 (ZnT7) and Slc30a8 (ZnT8) in mice abolishes glucose-stimulated insulin secretion (GSIS) in isolated islets, whereas deletion of either gene alone has no effect on GSIS in isolated islets; Slc30a7 deletion alone impairs glucose tolerance in vivo, reduces glucose-stimulated plasma insulin, pancreatic insulin content, hepatic glycogen, and alters islet morphology increasing the α- to β-cell ratio. Single and double knockout mice, oral glucose tolerance test, GSIS in isolated islets, pancreatic insulin content measurement, islet morphology analysis Endocrinology High 27754787
2017 ZnT7 is localized to the sarco(endo)plasmic reticulum (S(E)R) in cardiomyocytes; under hyperglycemia, decreased ZnT7 expression combined with increased ZIP7 activity causes redistribution of free Zn2+ (increased cytosolic, decreased S(E)R Zn2+) and contributes to ER stress and cardiac dysfunction. Subcellular fractionation, S(E)R isolation, FRET-based Zn2+ sensors, siRNA silencing of CK2α, Western blot Diabetes Medium 28232492
2017 ZNT7 physically interacts with CD40 in B lymphocytes (demonstrated by immunoprecipitation); ZNT7 knockdown reduces CD40 cell surface expression and impairs CD154-CD40-mediated p38 MAPK phosphorylation; ZNT7 overexpression up-regulates this signaling. Immunoprecipitation, flow cytometry for CD40 surface expression, Western blot for p38 MAPK phosphorylation, siRNA knockdown and overexpression FEBS open bio Medium 28469980
2018 ZnT7 is also localized to mitochondria (mitochondrial matrix) in cardiomyocytes in addition to the S(E)R; under hyperglycemia, increased ZnT7 on mitochondria is associated with elevated mitochondrial free Zn2+, increased ROS, depolarized mitochondrial membrane potential, and altered S(E)R-mitochondria coupling protein expression. Fluorescence microscopy, mitochondrial fractionation, biochemical analysis, FRET Zn2+ sensors Mitochondrion Medium 29307859
2018 ZnT7 protects renal tubular epithelial cells (NRK-52E) from high glucose-induced epithelial-to-mesenchymal transition (EMT); ZnT7 knockdown enhances EMT and activates MAPK/ERK and TGF-β/Smad pathways; ZnT7 overexpression inhibits these effects. Overexpression and siRNA knockdown in NRK-52E cells, Western blot for EMT markers and pathway activation, dual-fluorescent localization Kidney & blood pressure research Medium 29627824
2018 In znt7-KO skeletal muscle, insulin resistance is mechanistically linked to increased intracellular fatty acid levels, intracellular lipid accumulation, and elevated production of bioactive lipid mediators (12,13-DiHOME and 12-HETE); this is accompanied by up-regulation of Fabp3, Cd36, Slc27a1, and Slc27a4 fatty acid transporters and increased fatty acid oxidative capacity with enlarged mitochondria. znt7-KO mice, fatty acid and oxylipin profiling, electron microscopy, immunohistochemistry, quantitative RT-PCR, Western blot The Journal of biological chemistry High 29555680
2020 SLC30A7 knockdown decreases intracellular free zinc levels and reduces zinc distribution in the Golgi apparatus; SLC30A7 has anti-apoptotic effects in high glucose-induced apoptosis in renal tubular cells via the NFE2L2/HMOX1 signaling pathway; knockdown of NFE2L2 decreases SLC30A7 activity and increases apoptosis. siRNA knockdown, real-time RT-PCR, Western blot, intracellular zinc measurement, STZ-induced diabetic mouse model Diabetes research and clinical practice Medium 32949653
2021 In Drosophila, silencing of dZnT7 (the ZnT7 ortholog, localized on the Golgi apparatus) in a RafGOF scrib-/- tumor model enhances tumor growth, invasion, and migration; mechanistically, zinc deficiency in the Golgi caused by dZnT7 RNAi induces ER stress which activates JNK signaling via Atg9, promoting cell-autonomous and non-autonomous autophagy. Drosophila RNAi genetics, tumor growth/invasion assay, JNK pathway analysis, Atg9 epistasis Oncogene Medium 33649534
2022 miR-200c-3p directly targets SLC30A7 in human retinal microvascular endothelial cells (validated by dual luciferase reporter); miR-200c-3p negatively regulates SLC30A7 expression, and its knockdown mitigates high glucose-induced pyroptosis. Dual luciferase reporter assay, RT-qPCR, siRNA knockdown, Western blot, ELISA Human & experimental toxicology Medium 35607288
2023 Cryo-EM structures of human ZnT7 at 2.2–3.1 Å resolution reveal: (1) ZnT7 functions as a homodimer with tight interactions in both cytosolic and transmembrane (TM) domains; (2) each protomer has a single Zn2+-binding site in the TM domain; (3) ZnT7 operates as a Zn2+/H+ antiporter undergoing TM-helix rearrangement between inward-facing (negatively charged cytosolic cavity for Zn2+ entry) and outward-facing (widened luminal cavity for Zn2+ release) conformations; (4) the exceptionally long cytosolic histidine-rich loop binds two Zn2+ ions, seemingly facilitating Zn2+ recruitment to the TM transport pathway. Cryo-EM structure determination (2.2–3.1 Å), Zn2+-bound and unbound forms Nature communications High 37553324
2023 ZnT7 is localized on the mitochondrial matrix in cardiomyoblasts; ZnT7 overexpression increases mitochondrial free Zn2+ ([Zn2+]Mit), elevates ROS production, depolarizes mitochondrial membrane potential, increases markers of mitochondria-associated apoptosis and autophagy, and alters histone methylation marks (H3K27me3 and H3K36me1), linking ZnT7-mediated Zn2+ buffering to epigenetic regulation. Confocal immunofluorescence, FRET-based Zn2+/Ca2+ sensors, ROS measurement, mitochondrial membrane potential assay, Western blot for histone modifications Journal of trace elements in medicine and biology Medium 37196548
2023 Compound heterozygous loss-of-function variants in SLC30A7 (c.21dup causing premature stop, and c.842+15T>C causing leaky splicing with premature stop) result in 80–96% reduction in ZnT7 protein in affected individuals with stunted growth, testicular hypoplasia, and bone marrow failure (Ziegler-Huang Syndrome/BMF8). Exome sequencing, RNA-seq splicing analysis, Western blot for protein expression in patient cells Human molecular genetics Medium 36821639
2024 ZnT7 (as part of ZNT5-6 heterodimers and ZNT7 homodimers) supplies Zn2+ to Golgi α-mannosidase II (GMII), a key enzyme in N-glycan processing; loss of ZNT5-6 and ZNT7 function markedly reduces GMII activity and causes accumulation of hybrid-type N-glycans with reduction of complex-type glycans; lysosomal mannosidase (LAMAN) activity is not affected. Genetic disruption of ZNT5-6 and ZNT7 in cells, GMII enzyme activity assay, N-glycan profiling, xenograft tumor growth model The Journal of biological chemistry High 38762179
2025 ZNT7 deficiency in patient-derived B-EBV lymphoblasts causes excessive TP53 expression and decreased AKT activation; overexpression of wild-type ZNT7 in patient fibroblasts rescues insulin-stimulated AKT pathway activation; ZNT7 is expressed in myeloid and lymphoid lineage cells in human bone marrow, and Znt7-KO mice develop progressive cytopenia. Western blot for TP53 and pAKT in patient cells, wild-type ZNT7 transduction rescue, fluorescence microscopy for lineage co-expression, hematological analysis of Znt7-KO mice Journal of trace elements in medicine and biology Medium 40286389
2026 ERK1 specifically binds SLC30A7 and phosphorylates it at T297, driving redistribution of Zn2+ from cytosol into the Golgi lumen; SLC30A7 cooperates with zinc metallochaperone ZNG1 to mobilize Golgi zinc toward MMP2/3/9 activation, leading to E-cadherin degradation, β-catenin nuclear translocation, and MYC transcription in esophageal squamous cell carcinoma. Genetic deletion in mouse 4NQO tumorigenesis model, siRNA knockdown, ERK1 binding and phosphorylation assays (T297 site), co-IP for ZNG1 interaction, MMP activity assays, β-catenin pathway analysis, PDX model with ERK inhibitor nanoplatform Cancer letters Medium 42190790

Source papers

Stage 0 corpus · 30 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus. The Journal of biological chemistry 227 12446736
2004 Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane. The Journal of biological chemistry 137 15525635
2007 Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation. The Journal of biological chemistry 88 17954933
2017 Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart. Diabetes 73 28232492
2012 Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance. The Journal of biological chemistry 62 22854958
2013 ZnT7 can protect MC3T3-E1 cells from oxidative stress-induced apoptosis via PI3K/Akt and MAPK/ERK signaling pathways. Cellular signalling 58 23403124
2010 Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription. Experimental cell research 47 20599947
2018 Zn2+-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes. Mitochondrion 40 29307859
2018 Aberrant fatty acid metabolism in skeletal muscle contributes to insulin resistance in zinc transporter 7 (znt7)-knockout mice. The Journal of biological chemistry 39 29555680
2016 Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion. Endocrinology 34 27754787
2011 A null-mutation in the Znt7 gene accelerates prostate tumor formation in a transgenic adenocarcinoma mouse prostate model. Cancer letters 32 21621325
2023 Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn2+ uptake into the Golgi apparatus. Nature communications 22 37553324
2022 MiR-200c-3p regulates pyroptosis by targeting SLC30A7 in diabetic retinopathy. Human & experimental toxicology 19 35607288
2021 ZnT7 RNAi favors RafGOFscrib-/--induced tumor growth and invasion in Drosophila through JNK signaling pathway. Oncogene 16 33649534
2018 Protective Effect of Znt7 on High Glucose-Induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells. Kidney & blood pressure research 16 29627824
2009 Golgi apparatus localization of ZNT7 in the mouse cerebellum. Histology and histopathology 12 19283665
2009 ZNT7 and Zn2+ are present in different cell populations in the mouse testis. Histology and histopathology 11 19012241
2020 The Znt7-null mutation has sex dependent effects on the gut microbiota and goblet cell population in the mouse colon. PloS one 10 32991615
2017 ZNT7 binds to CD40 and influences CD154-triggered p38 MAPK activity in B lymphocytes-a possible regulatory mechanism for zinc in immune function. FEBS open bio 9 28469980
2024 ZNT5-6 and ZNT7 play an integral role in protein N-glycosylation by supplying Zn2+ to Golgi α-mannosidase II. The Journal of biological chemistry 8 38762179
2023 Overexpression of Slc30a7/ZnT7 increases the mitochondrial matrix levels of labile Zn2+ and modifies histone modification in hyperinsulinemic cardiomyoblasts. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 7 37196548
2022 De novo heterozygous variants in SLC30A7 are a candidate cause for Joubert syndrome. American journal of medical genetics. Part A 7 35751429
2020 SLC30A7 has anti-oxidant stress effects in high glucose-induced apoptosis via the NFE2L2/HMOX1 signal transduction pathway. Diabetes research and clinical practice 7 32949653
2014 Linking cellular zinc status to body weight and fat mass: mapping quantitative trait loci in Znt7 knockout mice. Mammalian genome : official journal of the International Mammalian Genome Society 7 24770585
2023 Identification of novel compound heterozygous variants in the SLC30A7 (ZNT7) gene in two French brothers with stunted growth, testicular hypoplasia and bone marrow failure. Human molecular genetics 6 36821639
2019 Subcongenic analysis of a quantitative trait locus affecting body weight and glucose metabolism in zinc transporter 7 (znt7)-knockout mice. BMC genetics 4 30777014
2024 Investigation of cuproptosis regulator-mediated modification patterns and SLC30A7 function in GBM. Aging 3 38393693
2008 Expression of zinc transporter ZnT7 in mouse superior cervical ganglion. Autonomic neuroscience : basic & clinical 3 18499530
2026 SLC30A7 phosphorylation by ERK1 promotes esophageal squamous cell carcinoma tumorigenesis via activating MMP2/3/9-β-catenin signaling. Cancer letters 0 42190790
2025 Reduced AKT activation accompanied with high TP53 expression is implicated in the impaired hematogenesis in Ziegler-Huang syndrome and the Znt7 null mice partially recapitulates the human disease linked to pancytopenia. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 0 40286389

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