Affinage

WWC1

Protein KIBRA · UniProt Q8IX03

Length
1113 aa
Mass
125.3 kDa
Annotated
2026-06-11
100 papers in source corpus 42 papers cited in narrative 42 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

WWC1/KIBRA is a multidomain WW- and C2-domain scaffold that couples cell-junctional and cytoskeletal cues to the Hippo growth-control pathway and, in neurons, to synaptic plasticity machinery (PMID:12559952, PMID:20159598). As a conserved upstream Hippo component it forms an apical complex with Merlin and Expanded that recruits Salvador and the Hippo/Warts kinases to activate the core cascade (PMID:20159598, PMID:20159599, PMID:20159600, PMID:28292426); in mammalian cells KIBRA associates with and stimulates LATS1/2 hydrophobic-motif phosphorylation and stabilizes LATS2 against ubiquitination, thereby driving YAP Ser127 phosphorylation and cytoplasmic sequestration in an MST-independent manner (PMID:21233212, PMID:22614006). This activity is integrated with mechanotransduction through cooperation with PTPN14 to restrain YAP/TAZ nuclear entry and suppress migration, EMT, and metastasis (PMID:25023289, PMID:29562176), and KIBRA is epigenetically silenced via an EZH2–H3K27me3–DNMT1 complex in triple-negative breast cancer (PMID:30121333). KIBRA additionally controls epithelial apical polarity and exocytosis by binding the PAR3–aPKC–PAR6 complex and directly inhibiting aPKC kinase activity (PMID:21497093), and stabilizes Rab27a by blocking its ubiquitination to govern exosome secretion (PMID:30967557) and angiomotin proteins by recruiting USP9X for their deubiquitination (PMID:37528078). In the nervous system KIBRA is a postsynaptic density scaffold that anchors PKMzeta at activated synapses and protects it from proteasomal degradation to maintain late-LTP and long-term memory (PMID:24117625, PMID:38924398, PMID:38299587), regulates GluA1-AMPAR recycling and surface expression and dendritic spine morphology (PMID:21943600, PMID:27498008, PMID:25750616), and joins AMPAR-regulatory complexes when released from inhibitory sequestration by LATS1/2; MST1/2-driven LATS phosphorylation strengthens WWC1–LATS binding and withholds WWC1 from AMPAR complexes, so disrupting this interaction enhances synaptic transmission and cognition (PMID:36476872, PMID:38687825). KIBRA is heavily phospho-regulated across the cell cycle by Aurora, CDK1, ERK, and RSK kinases (PMID:21878642, PMID:22904328, PMID:22784093, PMID:24269383) and is an ATM substrate required for DNA double-strand break repair (PMID:26929199).

Mechanistic history

Synthesis pass · year-by-year structured walk · 27 steps
  1. 2003 Medium

    Establishing KIBRA's domain architecture defined it as a WW/C2 scaffold capable of binding PPxY-motif partners, framing all subsequent interaction work.

    Evidence Yeast two-hybrid, in vitro PPxY binding, and transfection localization of Myc-tagged KIBRA

    PMID:12559952

    Open questions at the time
    • No physiological in vivo partner identified at this stage
    • Function of C2 and glutamate-rich domains undefined
  2. 2004 Medium

    Identifying PKCzeta as a KIBRA interactor and kinase linked KIBRA to atypical PKC signaling, an axis later extended to neuronal PKMzeta and epithelial aPKC.

    Evidence Co-IP and in vitro kinase assay

    PMID:15081397

    Open questions at the time
    • Functional consequence of phosphorylation not defined
    • Cellular context not established
  3. 2006 Medium

    Linking KIBRA to DLC1 and histone H3 at ER-responsive promoters proposed a nuclear/transcriptional co-regulatory role distinct from its later scaffold functions.

    Evidence Reciprocal Co-IP, in vitro pulldown, ChIP

    PMID:16684779

    Open questions at the time
    • Nuclear role not integrated with predominantly cytoplasmic localization
    • Not independently extended in later corpus
  4. 2008 Medium

    Multiple partner and dimerization studies established KIBRA as a polarity- and receptor-associated scaffold (PATJ, synaptopodin, DDR1) that self-associates and concentrates at the postsynaptic density.

    Evidence Yeast two-hybrid, Co-IP, knockdown migration assays, in vitro dimerization binding, IHC/fractionation

    PMID:18190796 PMID:18596123 PMID:18672031

    Open questions at the time
    • Functional hierarchy among partners unclear
    • Postsynaptic role not yet mechanistically defined
  5. 2010 High

    Three concurrent Drosophila studies placed Kibra as a conserved upstream Hippo pathway component acting with Merlin and Expanded to drive the core kinase cascade and Yorkie phosphorylation.

    Evidence Genetic epistasis, Co-IP, immunofluorescence, RNAi with phosphorylation readouts; conservation tested in human cells

    PMID:20159598 PMID:20159599 PMID:20159600

    Open questions at the time
    • Direct mammalian kinase target not yet defined
    • Mechanism of cascade activation by the complex unresolved
  6. 2011 High

    Mammalian KIBRA was shown to directly activate LATS1/2 and stabilize LATS2, providing the biochemical mechanism by which it promotes YAP phosphorylation and cytoplasmic retention.

    Evidence Co-IP, kinase/phosphorylation assays, ubiquitination assay, KD/OE

    PMID:21233212

    Open questions at the time
    • Structural basis of LATS activation not resolved
    • Regulation of KIBRA-LATS engagement not yet defined
  7. 2011 High

    KIBRA's role in epithelial polarity was mechanistically defined as direct aPKC inhibition controlling apical domain size and exocytosis.

    Evidence Co-IP, shRNA in MDCK 3D cysts, aPKC in vitro kinase assay, immunofluorescence

    PMID:21497093

    Open questions at the time
    • Relationship between aPKC inhibition and Hippo activation unresolved
    • In vivo epithelial relevance not tested here
  8. 2011 High

    KIBRA was established as a postsynaptic regulator of AMPAR trafficking and plasticity, with knockout mice showing LTP/LTD and memory deficits, anchoring its neuronal function.

    Evidence Co-IP with PICK1/AMPAR, AMPAR recycling assay, electrophysiology and behavior in KIBRA KO mice

    PMID:21943600

    Open questions at the time
    • Molecular link between KIBRA and recycling machinery incomplete
    • Relationship to Hippo signaling in neurons not addressed
  9. 2011 High

    KIBRA was shown to undergo cell-cycle-dependent, Aurora-driven phosphorylation reversed by PP1, connecting it to mitotic regulation and phospho-dependent Merlin binding.

    Evidence In vitro kinase assay, site-directed mutagenesis, Co-IP, phospho-specific antibodies, cell-cycle synchronization

    PMID:21878642

    Open questions at the time
    • Functional output of Ser539 phosphorylation beyond Merlin binding unclear
  10. 2012 Medium

    Mitotic studies expanded KIBRA's cell-cycle role to Aurora-A activation, LATS2 centrosome targeting, and CDK1/CDC14-regulated mitotic exit under spindle stress.

    Evidence In vitro kinase/phosphatase assays, mutagenesis, Co-IP, siRNA mitotic phenotyping

    PMID:22784093 PMID:22904328

    Open questions at the time
    • Integration with interphase Hippo signaling unclear
    • Physiological significance of spindle-stress phospho-sites untested in vivo
  11. 2012 Medium

    Loss of KIBRA was shown to drive EMT through MST-independent reduction of LATS/YAP phosphorylation, framing KIBRA as a tumor suppressor branch of Hippo signaling.

    Evidence shRNA KD, phosphorylation Westerns, 3D morphogenesis, expression analysis

    PMID:22614006

    Open questions at the time
    • Upstream activator substituting for MST not identified
    • In vivo tumor relevance not tested here
  12. 2013 High

    KIBRA was defined as the stabilizer that protects PKMzeta from proteasomal degradation, providing the molecular basis for its role in maintaining long-term memory.

    Evidence Co-IP, proteasome inhibition, KIBRA KD in rats and KO in mice, behavioral assays

    PMID:24117625

    Open questions at the time
    • Structural basis of the C-terminal PKMzeta-binding motif not yet solved
    • Mechanism preventing degradation not detailed
  13. 2013 Medium

    Identification of ERK/RSK phosphorylation sites tied KIBRA's phospho-state to cell migration and proliferation control in cancer cells.

    Evidence In vitro kinase assay, mutagenesis, Co-IP, migration/proliferation assays

    PMID:24269383

    Open questions at the time
    • Downstream effectors of these phospho-sites unclear
    • Interplay with Hippo phospho-regulation unresolved
  14. 2013 Medium

    Common C2-domain SNPs were shown to alter Ca2+-dependent phosphoinositide binding, providing a structural rationale for KIBRA membrane association and genetic variation.

    Evidence Lipid binding assays, structural modeling, genetic association

    PMID:23778582

    Open questions at the time
    • Cellular consequence of altered lipid binding not demonstrated
    • Link to memory phenotypes correlative
  15. 2014 Medium

    PTPN14 was identified as a KIBRA partner that cooperatively activates LATS1 and stabilizes it, extending KIBRA's Hippo regulatory network and migration control.

    Evidence Co-IP, LATS1 kinase assay, shRNA KD, 3D morphogenesis, rescue

    PMID:25023289

    Open questions at the time
    • Whether KIBRA and PTPN14 act in one complex or parallel pathways unresolved
  16. 2015 Medium

    KIBRA knockout altered dendritic spine morphology and synaptic ultrastructure, linking it to structural plasticity beyond receptor trafficking.

    Evidence KIBRA KO mice, Golgi staining, immunofluorescence, electron microscopy

    PMID:25750616

    Open questions at the time
    • Molecular driver of spine morphology changes not identified
  17. 2015 Medium

    Drosophila work implicated Kibra in starvation-induced autophagy downstream of aPKC, broadening its functional repertoire.

    Evidence Drosophila genetics, autophagy flux assays, Co-IP in S2 cells

    PMID:26551466

    Open questions at the time
    • Mammalian conservation of autophagy role untested
    • Mechanism connecting Kibra to autophagosome formation unclear
  18. 2016 Medium

    KIBRA was identified as an ATM substrate (Thr1006) required for efficient double-strand break repair, revealing a genome-maintenance function.

    Evidence Mutagenesis, phospho-(S/T)Q antibody, γ-H2AX/Comet/PFGE/TUNEL assays, KD/KO/KI

    PMID:26929199

    Open questions at the time
    • Direct role in NHEJ machinery not defined
    • Relationship to cytoplasmic scaffold functions unclear
  19. 2016 High

    Two neuronal studies showed KIBRA is required for activity-dependent actin remodeling, AMPAR insertion, and GluA1 recycling, and that its loss underlies tau-acetylation LTP deficits.

    Evidence Tau transgenic and lentiviral OE/KD mice, electrophysiology, AMPAR/actin assays, KIBRA rescue

    PMID:27041503 PMID:27498008

    Open questions at the time
    • Direct biochemical link between KIBRA and actin machinery not defined
  20. 2017 High

    Drosophila and podocyte studies refined KIBRA's spatial Hippo regulation (medial cortex, Salvador recruitment, Crumbs sequestration) and established its YAP-dependent control of cytoskeleton and injury resistance in vivo.

    Evidence Drosophila genetics/localization; KIBRA OE/KO in podocytes and mice with phosphorylation and injury models

    PMID:28292426 PMID:28982981

    Open questions at the time
    • Mammalian counterpart of medial-cortex localization not mapped
    • Crumbs-equivalent sequestration in mammals untested
  21. 2018 Medium

    KIBRA was shown to cooperate with PTPN14 in mechanotransduction-controlled YAP/TAZ exclusion and to suppress metastasis, while EZH2-mediated promoter silencing explained KIBRA loss in TNBC.

    Evidence In vivo metastasis and tumorsphere assays, Co-IP, fractionation; ChIP/MeDIP/bisulfite sequencing with EZH2 KD

    PMID:29562176 PMID:30121333

    Open questions at the time
    • Mechanosensing input upstream of KIBRA not molecularly defined
  22. 2019 High

    KIBRA was established as a stabilizer of partner proteins by blocking their ubiquitination — stabilizing Rab27a to control exosome secretion and binding Dendrin via its WW12 tandem with structurally defined nanomolar affinity to support synaptic transmission and memory.

    Evidence Co-IP, ubiquitination assay, KO mice, exosome quantification; crystal structure, ITC, peptide inhibitor, electrophysiology, behavior

    PMID:30784589 PMID:30967557

    Open questions at the time
    • Selectivity determinants for KIBRA's stabilization targets incompletely defined
    • Disease mutation effects on Dendrin binding only partly characterized
  23. 2019 Medium

    Aplysia work demonstrated isoform-specific KIBRA–PKM stabilization, showing structural 'handle' selectivity governs which PKM is protected and which memory is maintained.

    Evidence Isoform overexpression and dominant-negative competition in Aplysia sensorimotor neurons, facilitation assays

    PMID:31537706

    Open questions at the time
    • Mammalian isoform selectivity not tested
    • Structural handle not resolved at atomic level
  24. 2021 Medium

    Hippo activation was shown to feedback-degrade Kibra via SCFSlimb ubiquitination patterned by mechanical tension, revealing autoregulation of the pathway.

    Evidence Drosophila genetics, ubiquitination assays, live imaging

    PMID:33555257

    Open questions at the time
    • Mammalian conservation of Slimb/βTrCP-mediated KIBRA turnover untested
  25. 2022 High

    Studies established that LATS kinases sequester WWC1 from AMPAR complexes under basal conditions, so disrupting WWC1–LATS binding boosts synaptic WWC1 and memory, unifying the Hippo and plasticity functions.

    Evidence Cell-surface proteomics, point-mutation knock-in mice, inducible KO, electrophysiology, behavior

    PMID:36465112 PMID:36476872

    Open questions at the time
    • Trigger releasing WWC1 from LATS during plasticity not fully defined here
  26. 2023 High

    Work resolved upstream control of KIBRA localization/activity (aPKC junctional tethering vs actomyosin medial activation) and defined the WWC–USP9X–angiomotin stabilization axis as critical for spine density and memory.

    Evidence Drosophila live imaging/genetics; Co-IP, deubiquitination assays, neuron-specific conditional KO and AMOT rescue

    PMID:37528078 PMID:37729921

    Open questions at the time
    • Mammalian aPKC/actomyosin control of KIBRA localization not directly tested
    • How AMOT stabilization feeds neuronal plasticity unresolved
  27. 2024 High

    Multiple studies converged on the WWC1–PKMzeta and WWC1–LATS/MST axes as pharmacologically tractable nodes: PKMzeta-anchoring antagonists erase memory, CT-KIBRA rescues tau-driven deficits, and MST1/2 inhibition releases WWC1 to enhance cognition in disease models.

    Evidence Peptide antagonists with PKMzeta KO epistasis, CT-KIBRA in tau transgenics with human biomarkers, MST1/2 inhibition in mice/organoids with electrophysiology and behavior

    PMID:38299587 PMID:38687825 PMID:38924398

    Open questions at the time
    • Long-term safety/specificity of disrupting WWC1 interactions unknown
    • Structural basis of KIBRA-PKMzeta dimer not solved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How KIBRA's diverse functions — Hippo activation, aPKC/polarity control, PKMzeta anchoring, partner stabilization, mitotic regulation, and DNA repair — are coordinated through a single phospho- and localization-regulated scaffold remains unresolved.
  • No unified structural model integrating WW, C2, and C-terminal motif engagements
  • Switch logic determining which partner KIBRA engages in a given context unknown
  • Mammalian conservation of several Drosophila regulatory mechanisms untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0098772 molecular function regulator activity 4 GO:0008289 lipid binding 1 GO:0042393 histone binding 1
Localization
GO:0005856 cytoskeleton 2 GO:0005886 plasma membrane 2 GO:0005634 nucleus 1 GO:0005829 cytosol 1
Pathway
R-HSA-112316 Neuronal System 3 R-HSA-162582 Signal Transduction 3 R-HSA-1640170 Cell Cycle 3 R-HSA-1266738 Developmental Biology 2 R-HSA-5653656 Vesicle-mediated transport 1 R-HSA-73894 DNA Repair 1
Partners
LATS1LATS2NF2PKMZETAPRKCZPTPN14RAB27AUSP9X
Complex memberships
KIBRA-DDR1-PKCzeta trimeric complexKIBRA-PKMzeta synaptic complexKibra-Merlin-Expanded apical Hippo complexPAR3-aPKC-PAR6 polarity complex

Evidence

Reading pass · 42 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 KIBRA was identified as a novel WW domain-containing protein with two N-terminal WW domains, an internal C2-like domain, and a C-terminal glutamic acid-rich stretch. The first WW domain specifically binds PPxY motifs in vitro. Transient transfection showed cytoplasmic localization with perinuclear enrichment. Yeast two-hybrid screen, in vitro interaction studies, transient transfection with Myc-tagged constructs Biochemical and biophysical research communications Medium 12559952
2004 Protein kinase C zeta (PKCzeta) was identified as a KIBRA-interacting protein, and KIBRA is a novel substrate for PKCzeta phosphorylation. Co-immunoprecipitation, in vitro kinase assay Biochemical and biophysical research communications Medium 15081397
2006 KIBRA interacts with dynein light chain 1 (DLC1) both in vitro and in vivo, and the KIBRA-DLC1 complex is recruited to ER-responsive promoters. KIBRA-DLC1 interaction is required for estrogen receptor transactivation. KIBRA interacts with histone H3 via its glutamic acid-rich region, facilitating optimal ER transactivation. Co-immunoprecipitation, in vitro pulldown, chromatin immunoprecipitation (ChIP) The Journal of biological chemistry Medium 16684779
2008 KIBRA was identified as an interaction partner of the polarity protein PATJ via yeast two-hybrid screen; the last four amino acids of KIBRA mediate binding to the eighth PDZ domain of PATJ. KIBRA also directly binds to synaptopodin. Stable knockdown of KIBRA in podocytes impaired directed cell migration. Yeast two-hybrid screen, co-immunoprecipitation, stable knockdown, directed migration assay Journal of the American Society of Nephrology Medium 18596123
2008 KIBRA binds via its WW domains to a PPxY motif in the tyrosine kinase receptor DDR1, and this interaction is disrupted by DDR1 ligands collagen type I or IV. KIBRA, DDR1, and PKCzeta form a trimeric complex. Overexpression and knockdown studies showed KIBRA promotes collagen-stimulated MAPK cascade activation. Co-immunoprecipitation, overexpression/knockdown, MAPK activation assay Biochimica et biophysica acta Medium 18190796
2008 KIBRA can form head-to-tail homodimers, and dimerization is mediated by the internal C2-like domain. KIBRA is enriched at the postsynaptic density in hippocampal neurons with somatodendritic distribution. Binding studies (in vitro), immunohistochemistry, subcellular fractionation Neuroscience Medium 18672031
2009 KIBRA co-immunoprecipitates with PKMzeta (the brain-specific variant of PKCzeta) in adult mouse brain, and co-localizes with PKMzeta in hippocampal CA1, CA3, and dentate gyrus neurons. Co-immunoprecipitation using anti-KIBRA antibody, immunohistochemistry, in situ hybridization Bioscience, biotechnology, and biochemistry Medium 19129633
2010 Drosophila Kibra functions as an upstream component of the Hippo signaling pathway together with Merlin and Expanded, forming a protein complex localized to the apical domain of epithelial cells. This complex regulates the Hippo kinase cascade via direct binding to Hpo and Sav. Kibra loss phenocopies hippo pathway mutants. Genetic epistasis in Drosophila, co-immunoprecipitation, immunofluorescence localization, loss-of-function analysis Developmental cell High 20159598
2010 Drosophila Kibra colocalizes and associates with Merlin (Mer) and Expanded (Ex), promotes the Mer/Ex association, and this association is conserved in human cells. Kibra complexes with Warts and Kibra depletion in tissue culture cells induces marked reduction in Yki phosphorylation without affecting the Yki/Wts interaction. Co-immunoprecipitation, RNAi knockdown, phosphorylation assays, immunofluorescence Developmental cell High 20159599
2010 Drosophila Kibra acts upstream of Hippo and Merlin in the Hippo signaling pathway, acts synergistically with Expanded, and physically interacts with Merlin. Kibra predominantly acts in the Merlin branch upstream of the core kinase cascade. Genetic epistasis in Drosophila, co-immunoprecipitation, loss-of-function analysis Developmental cell High 20159600
2011 Human KIBRA associates with and activates LATS1 and LATS2 kinases by stimulating their phosphorylation on the hydrophobic motif. KIBRA overexpression stimulates YAP phosphorylation; depletion reduces YAP phosphorylation. KIBRA stabilizes LATS2 by inhibiting its ubiquitination. Co-immunoprecipitation, phosphorylation assays, RNAi knockdown, overexpression, ubiquitination assay The Journal of biological chemistry High 21233212
2011 KIBRA directly binds to PICK1 and forms a complex with AMPA receptors (AMPARs) in neurons. KIBRA knockdown accelerates the rate of AMPAR recycling following NMDA receptor-induced internalization. Genetic deletion of KIBRA in mice impairs both LTD and LTP at hippocampal Schaffer collateral-CA1 synapses and causes severe deficits in contextual fear learning and memory. Co-immunoprecipitation, AMPAR recycling assay, electrophysiology in KIBRA knockout mice, behavioral memory tests Neuron High 21943600
2011 KIBRA binds to the PAR3-aPKC-PAR6 complex and localizes at tight junctions and apical domains in epithelial cells. KIBRA knockdown causes expansion of the apical domain and suppresses apical-containing vacuole formation through enhanced de novo apical exocytosis. KIBRA directly inhibits the kinase activity of aPKC in vitro. Co-immunoprecipitation, shRNA knockdown in MDCK 3D cysts, aPKC in vitro kinase assay, immunofluorescence Current biology High 21497093
2011 KIBRA is phosphorylated in a cell cycle-dependent manner with highest phosphorylation in mitosis. Aurora-A and Aurora-B kinases phosphorylate KIBRA both in vitro and in vivo, with Ser539 as the primary phosphorylation site. Wild-type (but not catalytically inactive) protein phosphatase 1 (PP1) associates with KIBRA and dephosphorylates Aurora-phosphorylated KIBRA. KIBRA associates with NF2/Merlin in a Ser539 phosphorylation-dependent manner. KIBRA depletion impairs Aurora-A/PP1 interaction. In vitro kinase assay, site-directed mutagenesis, co-immunoprecipitation, phospho-specific antibodies, cell cycle synchronization The Journal of biological chemistry High 21878642
2011 In Drosophila R8 photoreceptors, Kibra (together with Merlin and Lgl, but not Expanded or Fat) is required for Warts expression and activity to specify Rh6 fate, demonstrating a cell-type-specific subset of the Hippo pathway operating in postmitotic neuronal fate specification. Drosophila genetic loss-of-function, epistasis analysis, immunostaining Developmental cell Medium 22055343
2012 KIBRA activates Aurora kinases and is required for full Aurora kinase activation during mitosis. KIBRA promotes phosphorylation of LATS2 on Ser83 by activating Aurora-A, controlling LATS2 centrosome localization. Aurora-A is not required for KIBRA to associate with LATS2. KIBRA knockdown causes mitotic abnormalities including spindle/centrosome defects and chromosome misalignment. In vitro kinase assay, co-immunoprecipitation, siRNA knockdown, immunofluorescence, mitotic phenotype analysis The Journal of biological chemistry Medium 22904328
2012 KIBRA is phosphorylated by CDK1 at Ser542 and Ser931 in response to spindle damage stress. CDC14A/B phosphatases associate with KIBRA and dephosphorylate CDK1-phosphorylated KIBRA in vitro and in cells. CDK1-non-phosphorylatable KIBRA shows reduced interaction with CDC14B. Phospho-regulation of KIBRA by CDK1 and CDC14 is involved in mitotic exit under spindle stress. In vitro kinase assay, site-directed mutagenesis, co-immunoprecipitation, inducible expression cell lines, phospho-specific antibodies The Biochemical journal Medium 22784093
2012 Loss of KIBRA in MCF10A cells produces epithelial-to-mesenchymal transition (EMT) features with decreased LATS and YAP phosphorylation but not MST1/2, demonstrating MST-independent regulation of Hippo signaling. Ectopic KIBRA expression antagonizes YAP via serine 127 phosphorylation. shRNA knockdown, phosphorylation assays by Western blot, 3D morphogenesis assay, gene expression analysis Oncogene Medium 22614006
2013 KIBRA is phosphorylated by ERK1/2 at Ser548 and by RSK1/2 at Thr929 and Ser947 in vitro and in cells. RSK-mediated phosphorylation is required for KIBRA binding to RSK1 but not RSK2. KIBRA knockdown impaired cell migration and proliferation in breast cancer cells; phospho-regulation by ERK1/2 and RSK1/2 is required for proper cell proliferation and migration. In vitro kinase assay, site-directed mutagenesis, co-immunoprecipitation, inducible expression cell lines, migration/proliferation assays Cellular signalling Medium 24269383
2013 KIBRA is necessary and sufficient to stabilize PKMzeta against proteasomal degradation. A short amino acid motif near the C-terminus of KIBRA mediates binding to PKMzeta. Hippocampal knockdown of KIBRA in rats and KIBRA knockout in mice both result in decreased spatial memory performance and decreased PKMzeta protein levels. Co-immunoprecipitation, proteasome inhibitor experiments, KIBRA knockdown/knockout, behavioral memory assays, Western blot Journal of neurochemistry High 24117625
2013 Two common missense SNPs (rs3822660G/T [M734I], rs3822659T/G [S735A]) in the C2 domain of KIBRA produce variants with distinct Ca2+-dependent binding preferences for monophosphorylated phosphatidylinositols, likely due to differences in dynamics and folding of the lipid-binding pocket. Lipid binding assays, structural modeling/dynamics analysis, genetic association Translational psychiatry Medium 23778582
2014 PTPN14 interacts with KIBRA through the PPXY domain of PTPN14 and WW domain of KIBRA. PTPN14 and KIBRA can activate LATS1 independently and cooperatively. PTPN14 increases LATS1 protein stability. KIBRA re-expression rescues PTPN14-knockdown-induced cell migration defects and aberrant 3D morphogenesis through LATS1 activation and cytoplasmic YAP sequestration. Co-immunoprecipitation, LATS1 kinase assay, shRNA knockdown, 3D morphogenesis assay, rescue experiments The Journal of biological chemistry Medium 25023289
2015 Deletion of KIBRA in mice increases filopodial-like long dendritic spines in neocortical and hippocampal neurons both in vivo (Golgi staining) and in vitro. Electron microscopy revealed fewer perforated synapses and spinules in KIBRA knockout neurons. Constitutive KIBRA knockout mice, Golgi impregnation, immunofluorescence, electron microscopy Frontiers in neuroanatomy Medium 25750616
2016 Acetylation of tau at K274 and K281 (mimicked by tauKQ mutation) reduces postsynaptic KIBRA levels and disrupts activity-induced postsynaptic actin remodeling and AMPA receptor insertion. LTP deficits from tauKQ were rescued by promoting actin polymerization or by KIBRA expression. Transgenic mouse model, electrophysiology (LTP), AMPAR insertion assay, actin polymerization assay, KIBRA rescue expression Neuron High 27041503
2016 KIBRA overexpression increases constitutive recycling of GluA1-containing AMPA receptors and favors their activity-dependent surface expression, increases LTP but prevents LTD induction, and causes dendritic rearrangements. KIBRA knockdown abolishes LTP, decreases GluA1-AMPAR recycling, and reduces dendritic arborization. Lentiviral KIBRA overexpression/knockdown in mice, electrophysiology (LTP/LTD), AMPAR surface expression assay, confocal microscopy of dendritic morphology Neurobiology of learning and memory High 27498008
2017 In Drosophila, Merlin and Kibra activate Hippo signaling in parallel to Expanded at a spatially distinct cellular domain (the medial apical cortex). Merlin and Kibra together recruit the adapter protein Salvador, which recruits Hippo kinase. Crumbs has a dual effect: promotes Expanded function but sequesters Kibra to downregulate Hippo signaling. Drosophila genetics (loss-of-function, epistasis), immunofluorescence localization, protein interaction assays Developmental cell High 28292426
2017 KIBRA overexpression in murine podocytes promoted LATS kinase phosphorylation leading to YAP Ser-127 phosphorylation, YAP cytoplasmic sequestration, and reduction in YAP target gene expression. KIBRA overexpression induced actin cytoskeletal disruption and reduction of focal adhesions, rescued by YAP overexpression. Constitutive KIBRA knockout mice displayed reduced phospho-YAP and were protected from acute podocyte foot process effacement. KIBRA overexpression/knockout in podocytes and mice, phosphorylation assays, immunofluorescence, in vivo protamine sulfate injury model The Journal of biological chemistry High 28982981
2018 KIBRA functions cooperatively with PTPN14 to trigger mechanotransduction-regulated signals that inhibit nuclear localization of YAP/TAZ. Re-expression of KIBRA impairs metastasis in vivo and inhibits tumorsphere formation by TNBC cells in vitro. In vivo metastasis assay, tumorsphere formation assay, co-immunoprecipitation, nuclear/cytoplasmic fractionation Cell reports Medium 29562176
2018 The EZH2-H3K27me3-DNMT1 complex is enriched at the wwc1 promoter and mediates epigenetic silencing of KIBRA in triple-negative breast cancer cells. EZH2 knockdown leads to partial increase in KIBRA expression and reduction in H3K27me3 and DNMT1 at the promoter. Co-immunoprecipitation, ChIP, bisulfite sequencing, MeDIP, ChIP-qPCR, shRNA knockdown Cellular signalling Medium 30121333
2019 KIBRA stabilizes Rab27a by preventing its ubiquitination and proteasomal degradation through direct protein interaction. KIBRA knockdown or overexpression in neuronal and podocyte cell lines decreases or increases exosome secretion respectively. KIBRA depletion increases MVB size and number. KIBRA knockout mouse brains show significantly decreased Rab27a. Co-immunoprecipitation, ubiquitination assay, KIBRA KO mouse, nanoparticle tracking analysis (exosome quantification), electron microscopy of MVBs Nature communications High 30967557
2019 Kibra binds to postsynaptic density-enriched Dendrin via its N-terminal WW1-WW2 tandem domains with nanomolar affinity. Crystal structure of Kibra WW12 in complex with Dendrin PY motifs was determined. A peptide inhibitor blocking Kibra-Dendrin interaction attenuated excitatory synaptic transmission, blocked LTP induction, and impaired spatial learning and memory. A Tourette syndrome patient mutation in Kibra causes defects in Dendrin binding. Crystal structure determination, isothermal titration calorimetry (ITC), peptide inhibitor design, electrophysiology, behavioral memory assays Cell reports High 30784589
2019 KIBRA stabilization of PKMzeta is isoform-specific in Aplysia: different splice isoforms of KIBRA in a conserved C-terminal region stabilize different PKM isoforms based on an isoform-specific α-helix 'handle' in PKMs. Isoform-specific competition for KIBRA stabilization determines the selectivity of dominant-negative PKMs in erasing long-term facilitation. Overexpression in Aplysia sensorimotor neurons, dominant-negative PKM isoform competition, synaptic facilitation assays The Journal of neuroscience Medium 31537706
2021 In Drosophila, Hippo pathway activation promotes Kibra degradation via SCFSlimb-mediated ubiquitination independently of Yorkie-mediated transcription. This mechanism requires Merlin, Salvador, Hpo, and Warts, and functions independently of other upstream Hippo pathway activators. Kibra degradation is patterned by differences in mechanical tension across the wing. Drosophila genetics, ubiquitination assays, epistasis analysis, live imaging eLife Medium 33555257
2022 Under basal conditions, WWC1 and LATS kinases are associated, sequestering WWC1 from synaptic AMPAR complexes. A point mutation disrupting WWC1/LATS binding elevates WWC1 abundance in AMPAR complexes and improves hippocampal-dependent learning and memory in mice. Cell-surface proteomics in hippocampal tissue of Wwc1-deficient mice, hippocampus-specific interactome, point mutation knock-in, behavioral memory tests Cell reports High 36476872
2022 Adult-onset (but not juvenile-onset) deletion of KIBRA in forebrain neurons impairs LTP and long-term spatial memory. Adult KIBRA deletion decreases extrasynaptic AMPAR levels under basal conditions and impairs LTP-induced AMPAR upregulation. Inducible KIBRA knockout mouse, electrophysiology (LTP), AMPAR surface expression assay, behavioral memory tests iScience Medium 36465112
2023 In Drosophila epithelial cells, apical polarity network (via aPKC) tethers Kibra at the junctional cortex to silence its activity, while medial actomyosin flows promote Kibra-mediated Hippo complex formation at the medial cortex to activate the pathway. Drosophila genetics, live imaging, immunofluorescence, actomyosin perturbation experiments Developmental cell Medium 37729921
2023 WWC1 and its paralogs (WWC2/3) bind directly to angiomotin (AMOT) family proteins and recruit USP9X to deubiquitinate and stabilize Motins. Neuron-specific deletion of Wwc1 and Wwc2 reduces Molin levels, decreases dendritic spine density, and impairs memory and learning. Ectopic AMOT expression partially rescues these neuronal phenotypes. Co-immunoprecipitation, deubiquitination assays, neuron-specific conditional knockout mice, dendritic spine quantification, behavioral memory tests, rescue expression Cell death & disease High 37528078
2024 KIBRA complexes with PKMzeta at activated synapses, anchoring the kinase's potentiating action to maintain late-phase LTP and long-term spatial memory. Two structurally distinct KIBRA-PKMzeta dimerization antagonists disrupt established late-LTP and long-term memory without affecting basal synaptic transmission. The effect of both antagonists requires PKMzeta (no effect in PKMzeta knockout mice). Peptide antagonists of KIBRA-PKMzeta interaction, electrophysiology (late-LTP), PKMzeta knockout mouse epistasis, behavioral memory assays, co-immunoprecipitation Science advances High 38924398
2024 The C-terminus of KIBRA (CT-KIBRA) restores synaptic plasticity and memory in transgenic mice expressing pathogenic human tau by stabilizing PKMzeta, without altering tau levels or preventing tau-induced synapse loss. Reduced brain KIBRA and increased CSF KIBRA are associated with cognitive impairment and pathological tau in disease. CT-KIBRA expression in tau transgenic mice, electrophysiology (LTP), PKMzeta protein level measurement, behavioral memory tests, human CSF/brain biomarker analysis The Journal of clinical investigation High 38299587
2024 Phosphorylation of LATS1/2 by upstream kinases MST1/2 enhances the interaction between WWC1 and LATS1/2, sequestering WWC1 from AMPAR complexes. Pharmacological inhibition of MST1/2 promotes dissociation of WWC1 from LATS1/2, increasing WWC1 in AMPAR-containing complexes, enhancing synaptic transmission, and improving cognition in healthy mice, Alzheimer's disease models, and aging models. Phosphorylation assays, co-immunoprecipitation, MST1/2 pharmacological inhibition in mice and human brain organoids, electrophysiology, cognitive behavioral assays Science signaling High 38687825
2016 KIBRA is a physiological substrate of ATM kinase; ATM phosphorylates KIBRA at Thr1006 within an SQ consensus motif. T1006 phosphorylation is essential for optimal DNA double-strand break repair, and KIBRA depletion compromises DNA repair functions, likely via the NHEJ pathway. Site-directed mutagenesis, phospho-(S/T)Q antibody, γ-H2AX assay, pulsed-field gel electrophoresis, Comet assay, TUNEL assay, clonogenic survival assay, shRNA knockdown, CRISPR-Cas9 knockout Molecular and cellular biology Medium 26929199
2015 In Drosophila, Kibra is required for starvation-induced autophagy; absence of Kibra caused defects in autophagic vesicle formation and autophagic degradation. aPKC interacts with Kibra in S2 cells and Drosophila larva, and constitutively active aPKC decreased autophagic vesicle formation upstream of Kibra. Drosophila genetics, autophagy flux assays, co-immunoprecipitation in S2 cells, immunostaining Biochemical and biophysical research communications Medium 26551466

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Developmental cell 413 20159598
2006 Common Kibra alleles are associated with human memory performance. Science (New York, N.Y.) 330 17053149
2010 Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Developmental cell 329 20159599
2010 The WW domain protein Kibra acts upstream of Hippo in Drosophila. Developmental cell 266 20159600
2016 Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron 226 27041503
2019 KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a. Nature communications 193 30967557
2011 KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases. The Journal of biological chemistry 164 21233212
2003 Characterization of KIBRA, a novel WW domain-containing protein. Biochemical and biophysical research communications 132 12559952
2011 Regulation of AMPA receptor function by the human memory-associated gene KIBRA. Neuron 121 21943600
2012 KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals. Oncogene 115 22614006
2008 KIBRA modulates directional migration of podocytes. Journal of the American Society of Nephrology : JASN 108 18596123
2017 Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded. Developmental cell 96 28292426
2008 Evidence for an association between KIBRA and late-onset Alzheimer's disease. Neurobiology of aging 95 18789830
2004 KIBRA is a novel substrate for protein kinase Czeta. Biochemical and biophysical research communications 95 15081397
2007 KIBRA gene variants are associated with episodic memory in healthy elderly. Neurobiology of aging 91 17353070
2010 KIBRA: A New Gateway to Learning and Memory? Frontiers in aging neuroscience 81 20552044
2014 PTPN14 forms a complex with Kibra and LATS1 proteins and negatively regulates the YAP oncogenic function. The Journal of biological chemistry 78 25023289
2008 KIBRA genetic polymorphism influences episodic memory in later life, but does not increase the risk of mild cognitive impairment. Journal of cellular and molecular medicine 78 18194457
2008 Temporal-spatial expression and novel biochemical properties of the memory-related protein KIBRA. Neuroscience 73 18672031
2013 KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mζ. Journal of neurochemistry 70 24117625
2012 Association of KIBRA with episodic and working memory: a meta-analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 70 23065961
2016 Notch3 inhibits epithelial-mesenchymal transition by activating Kibra-mediated Hippo/YAP signaling in breast cancer epithelial cells. Oncogenesis 66 27841855
2007 Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk. Neurobiology of aging 66 17707552
2011 KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells. Current biology : CB 65 21497093
2009 KIBRA and CLSTN2 polymorphisms exert interactive effects on human episodic memory. Neuropsychologia 63 19804789
2014 KIBRA: In the brain and beyond. Cellular signalling 59 24642126
2008 Failure to replicate effect of Kibra on human memory in two large cohorts of European origin. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 59 18205171
2018 The EZH2- H3K27me3-DNMT1 complex orchestrates epigenetic silencing of the wwc1 gene, a Hippo/YAP pathway upstream effector, in breast cancer epithelial cells. Cellular signalling 58 30121333
2006 Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells. The Journal of biological chemistry 58 16684779
2013 KIBRA polymorphism is associated with individual differences in hippocampal subregions: evidence from anatomical segmentation using high-resolution MRI. The Journal of neuroscience : the official journal of the Society for Neuroscience 55 23926262
2011 Binary regulation of Hippo pathway by Merlin/NF2, Kibra, Lgl, and Melted specifies and maintains postmitotic neuronal fate. Developmental cell 55 22055343
2011 KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1. The Journal of biological chemistry 50 21878642
2018 KIBRA (WWC1) Is a Metastasis Suppressor Gene Affected by Chromosome 5q Loss in Triple-Negative Breast Cancer. Cell reports 46 29562176
2012 KIBRA regulates aurora kinase activity and is required for precise chromosome alignment during mitosis. The Journal of biological chemistry 43 22904328
2011 Frequent epigenetic inactivation of KIBRA, an upstream member of the Salvador/Warts/Hippo (SWH) tumor suppressor network, is associated with specific genetic event in B-cell acute lymphocytic leukemia. Epigenetics 43 21173572
2008 KIBRA gene variants are associated with episodic memory performance in subjective memory complaints. Neuroscience letters 43 18378080
2013 Phosphorylation of KIBRA by the extracellular signal-regulated kinase (ERK)-ribosomal S6 kinase (RSK) cascade modulates cell proliferation and migration. Cellular signalling 41 24269383
2019 Kibra Modulates Learning and Memory via Binding to Dendrin. Cell reports 40 30784589
2017 The Hippo pathway regulator KIBRA promotes podocyte injury by inhibiting YAP signaling and disrupting actin cytoskeletal dynamics. The Journal of biological chemistry 40 28982981
2017 Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway. Journal of experimental & clinical cancer research : CR 40 29017577
2008 KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. Biochimica et biophysica acta 40 18190796
2010 Association of common KIBRA variants with episodic memory and AD risk. Neurobiology of aging 38 21185624
2009 KIBRA Co-localizes with protein kinase Mzeta (PKMzeta) in the mouse hippocampus. Bioscience, biotechnology, and biochemistry 37 19129633
2011 Impact of common KIBRA allele on human cognitive functions. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 35 21346737
2013 Aging and KIBRA/WWC1 genotype affect spatial memory processes in a virtual navigation task. Hippocampus 34 23733450
2015 Impact of KIBRA Polymorphism on Memory Function and the Hippocampus in Older Adults. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 31 26156558
2012 Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression. The Biochemical journal 31 22784093
2018 Upregulated microRNA miR-21 promotes the progression of lung adenocarcinoma through inhibition of KIBRA and the Hippo signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 30 30372890
2016 The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond. Genes 30 27240404
2015 Genetics and functional imaging: effects of APOE, BDNF, COMT, and KIBRA in aging. Neuropsychology review 30 25666727
2010 Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls. Journal of psychiatric research 29 20185150
2018 KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden. Scientific reports 28 29391469
2016 KIBRA promotes prostate cancer cell proliferation and motility. The FEBS journal 28 27220053
2013 Common exonic missense variants in the C2 domain of the human KIBRA protein modify lipid binding and cognitive performance. Translational psychiatry 28 23778582
2010 Association study of KIBRA gene with memory performance in a Japanese population. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 27 20509760
2018 Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease. Neurobiology of aging 26 30201328
2013 WWC1 genotype modulates age-related decline in episodic memory function across the adult life span. Biological psychiatry 26 24290728
2020 TCF19 aggravates the malignant progression of colorectal cancer by negatively regulating WWC1. European review for medical and pharmacological sciences 25 32016966
2012 The KIBRA-aPKC connection: A potential regulator of membrane trafficking and cell polarity. Communicative & integrative biology 25 22808318
2021 Long non-coding RNA XIST alleviates sepsis-induced acute kidney injury through inhibiting inflammation and cell apoptosis via regulating miR-155-5p/WWC1 axis. The Kaohsiung journal of medical sciences 24 34431595
2020 WWC1 and NF2 Prevent the Development of Intrahepatic Cholangiocarcinoma by Regulating YAP/TAZ Activity through LATS in Mice. Molecules and cells 24 32451369
2009 Cognitive flexibility is associated with KIBRA variant and modulated by recent tobacco use. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 24 19606085
2016 The memory gene KIBRA is a bidirectional regulator of synaptic and structural plasticity in the adult brain. Neurobiology of learning and memory 23 27498008
2012 Association of KIBRA rs17070145 polymorphism and episodic memory in individuals with severe TBI. Brain injury 23 22794909
2017 Whole transcriptome profiling of the human hippocampus suggests an involvement of the KIBRA rs17070145 polymorphism in differential activation of the MAPK signaling pathway. Hippocampus 22 28380666
2012 KIBRA gene variants are associated with synchronization within the default-mode and executive control networks. NeuroImage 22 23266749
2013 The role of memory-related gene WWC1 (KIBRA) in lifetime posttraumatic stress disorder: evidence from two independent samples from African conflict regions. Biological psychiatry 20 23582269
2010 KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort. Dementia and geriatric cognitive disorders 20 20881395
2024 KIBRA anchoring the action of PKMζ maintains the persistence of memory. Science advances 19 38924398
2024 KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss. The Journal of clinical investigation 18 38299587
2019 SOX2 antagonizes WWC1 to drive YAP1 activation in esophageal squamous cell carcinoma. Cancer medicine 18 31560173
2017 Promoter methylation inhibits expression of tumor suppressor KIBRA in human clear cell renal cell carcinoma. Clinical epigenetics 17 29046731
2022 Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning. Cell reports 16 36476872
2015 Deletion of KIBRA, protein expressed in kidney and brain, increases filopodial-like long dendritic spines in neocortical and hippocampal neurons in vivo and in vitro. Frontiers in neuroanatomy 16 25750616
2024 Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA and inhibiting Hippo signaling pathway. Molecular therapy : the journal of the American Society of Gene Therapy 15 38414246
2024 Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice. Science signaling 15 38687825
2015 Kibra and aPKC regulate starvation-induced autophagy in Drosophila. Biochemical and biophysical research communications 15 26551466
2013 Age-dependent association of KIBRA gene polymorphism with Alzheimer's disease in Han Chinese. Molecular biology reports 15 24190487
2022 KIBRA regulates activity-induced AMPA receptor expression and synaptic plasticity in an age-dependent manner. iScience 14 36465112
2019 Isoform Specificity of PKMs during Long-Term Facilitation in Aplysia Is Mediated through Stabilization by KIBRA. The Journal of neuroscience : the official journal of the Society for Neuroscience 14 31537706
2014 Effects of the KIBRA Single Nucleotide Polymorphism on Synaptic Plasticity and Memory: A Review of the Literature. Current neuropharmacology 14 24851092
2013 Both PKMζ and KIBRA are closely related to reference memory but not working memory in a T-maze task in rats. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 14 24141945
2011 The role of memory-related gene polymorphisms, KIBRA and CLSTN2, on replicate memory assessment in the elderly. Journal of neural transmission (Vienna, Austria : 1996) 14 21643791
2023 WWC1/2 regulate spinogenesis and cognition in mice by stabilizing AMOT. Cell death & disease 13 37528078
2019 The Neuroprotection of KIBRA in Promoting Neuron Survival and Against Amyloid β-Induced Apoptosis. Frontiers in cellular neuroscience 13 31031595
2014 lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK. Cancers 13 24743776
2022 TAOK1 Promotes Proliferation and Invasion of Non-Small-Cell Lung Cancer Cells by Inhibition of WWC1. Computational and mathematical methods in medicine 12 36158126
2021 Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription. eLife 12 33555257
2018 Association of peripheral blood leukocyte KIBRA methylation with gastric cancer risk: a case-control study. Cancer medicine 12 29659170
2017 APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults. Cerebral cortex (New York, N.Y. : 1991) 12 27620974
2016 Phosphorylation-Dependent Regulation of the DNA Damage Response of Adaptor Protein KIBRA in Cancer Cells. Molecular and cellular biology 12 26929199
2015 Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals. Neuropsychologia 12 26415670
2023 Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling. Developmental cell 10 37729921
2019 KIBRA T allele influences memory performance and progression of cognitive decline: a 7-year follow-up study in subjective cognitive decline and mild cognitive impairment. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 10 30953258
2018 Loss of KIBRA function activates EGFR signaling by inducing AREG. Oncotarget 10 30042827
2017 Association of KIBRA polymorphism with risk of Alzheimer's disease: Evidence based on 20 case-control studies. Neuroscience letters 10 28859866
2017 WWC1 promotes podocyte survival via stabilizing slit diaphragm protein dendrin. Molecular medicine reports 10 28990091
2015 Genetic Association Between KIBRA Polymorphism and Alzheimer's Disease with in a Japanese Population. Neuromolecular medicine 10 25800888
2014 Association of KIBRA rs17070145 polymorphism with episodic memory in the early stages of a human neurodevelopmental disorder. Psychiatry research 10 25146696
2014 KIBRA gene polymorphism has no association with verbal or visual episodic memory performance. Frontiers in aging neuroscience 10 25339899

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