Affinage

WRAP53

Telomerase Cajal body protein 1 · UniProt Q9BUR4

Audit flag: wrong gene
Length
548 aa
Mass
59.3 kDa
Annotated
2026-06-11
46 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

The WRAP53 locus encodes two functionally distinct products from a single gene: an antisense RNA isoform (Wrap53α) that stabilizes p53 mRNA, and a WD40-domain scaffold protein (WRAP53β/TCAB1/WDR79) that chaperones telomerase trafficking and organizes Cajal bodies (PMID:19250907, PMID:21205863). As an RNA regulator, the Wrap53 transcript base-pairs directly with the 5' UTR of p53 mRNA to elevate p53 levels and is required for p53 induction after DNA damage (PMID:19250907), with the transcript itself bound and stabilized by CTCF through a dedicated RNA-binding region (PMID:24696455). The WRAP53β protein binds CAB-box motifs in telomerase RNA (hTR) and related scaRNAs to retain them in the nucleoplasm and prevent their sequestration in the nucleolus, thereby enabling TERT–hTR assembly and telomere elongation (PMID:21205863, PMID:37267110); it additionally recruits telomerase to telomeres independently of Cajal body integrity (PMID:22547674) and controls the conformation of the hTR CR4/5 domain to switch on catalytic activity without affecting enzyme assembly (PMID:29804836). WRAP53β is essential for Cajal body formation, mediating SMN–coilin and SMN–importin-β complex assembly and SMN nuclear import (PMID:21072240), and its proper folding and stability depend on the TRiC/CCT chaperonin (PMID:25467444). Disease-causing missense mutations in WRAP53β found in dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome patients misfold the protein, mislocalize telomerase, and abolish telomere elongation, Cajal body maintenance, and DNA double-strand break repair (PMID:21205863, PMID:32303682). Beyond these core roles, WRAP53β promotes cancer cell survival by suppressing mitochondrial apoptosis (PMID:21368886) and stabilizes USP7, UHRF1, and p21 by modulating their ubiquitination (PMID:28406480, PMID:29516630, PMID:33413389).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2009 High

    Established that the WRAP53 antisense transcript is not merely a genomic neighbor of p53 but a direct post-transcriptional regulator, answering how p53 mRNA is stabilized after DNA damage.

    Evidence siRNA knockdown, overexpression, and RNA-hybrid blocking with RT-PCR/immunoblot readouts targeting the p53 5' UTR

    PMID:19250907

    Open questions at the time
    • Does not define what proteins, if any, the RNA-RNA duplex recruits
    • Does not address whether the protein isoform contributes to this function
  2. 2010 High

    Identified the WRAP53 protein as a structural organizer of Cajal bodies, answering how the SMN complex is imported and targeted to these nuclear domains.

    Evidence RNAi knockdown, immunofluorescence, and reciprocal co-immunoprecipitation identifying coilin, SMN, and importin-β partners

    PMID:21072240

    Open questions at the time
    • Does not resolve whether scaffolding is direct or bridged
    • Does not connect Cajal body role to telomere biology
  3. 2011 High

    Linked WRAP53β to human disease and to telomerase trafficking, showing patient mutations redirect hTR from Cajal bodies to nucleoli and block telomere elongation.

    Evidence Dyskeratosis congenita patient mutations with fluorescence localization assays and telomere length analysis

    PMID:21205863

    Open questions at the time
    • Does not establish whether telomere recruitment requires Cajal bodies
    • Mechanism of nucleolar mislocalization unresolved
  4. 2011 Medium

    Showed WRAP53β is required for cancer cell survival by suppressing mitochondrial apoptosis, extending its role beyond nuclear trafficking.

    Evidence siRNA knockdown with Bax/Bak activation, mitochondrial membrane potential, cytochrome c release, and Bcl-2 rescue assays

    PMID:21368886

    Open questions at the time
    • No reconstitution of the apoptosis-suppressing mechanism
    • Direct molecular target in the mitochondrial pathway unidentified
  5. 2012 High

    Dissected the telomere-recruitment role from Cajal body scaffolding, demonstrating TCAB1 transports telomerase to telomeres independently of Cajal body integrity.

    Evidence Coilin depletion versus TCAB1 knockdown genetic epistasis, telomerase overexpression rescue, and hTERT point mutation analysis

    PMID:22547674

    Open questions at the time
    • Does not define the molecular determinants of telomere targeting
    • Relationship to CAB-box binding not fully resolved
  6. 2012 Medium

    Defined the RNA-binding specificity of WRAP53β as recognition of CAB-box UGAG motifs, generalizing its role to AluACA RNAs and scaRNAs.

    Evidence Co-IP, RNA co-IP, and CAB-box mutation analysis with cellular fractionation

    PMID:22892240

    Open questions at the time
    • Single-lab Co-IP without structural validation of the binding interface
    • Functional consequence of AluACA binding not established
  7. 2014 High

    Connected the WRAP53 RNA to upstream regulation by CTCF, showing CTCF binds the transcript through an RNA-binding region to control p53 expression.

    Evidence PAR-CLIP-seq, CTCF depletion, RBR mutagenesis, and p53 DNA damage response reporter assays

    PMID:24696455

    Open questions at the time
    • Does not explain how CTCF binding stabilizes the transcript mechanistically
    • Does not address the protein isoform
  8. 2014 High

    Established that WRAP53β stability depends on TRiC/CCT-mediated folding, explaining how patient mutations destabilize the protein and disrupt telomerase trafficking.

    Evidence Genome-wide siRNA imaging screen, TRiC depletion, Co-IP, telomere elongation, and patient mutation functional analysis

    PMID:25467444

    Open questions at the time
    • Does not resolve which structural elements TRiC engages
    • Does not address folding kinetics or co-chaperones
  9. 2016 High

    Tested whether TCAB1 is strictly required for telomere maintenance, showing a minimized hTR bypasses TCAB1 and Cajal bodies when TERT is overexpressed yet wild-type hTR shows altered telomerase action without TCAB1.

    Evidence CRISPR knockout of TCAB1 and coilin with minimized hTR reconstitution and telomere elongation assays

    PMID:27525486

    Open questions at the time
    • Did not identify the molecular basis of altered telomerase action on wild-type hTR
    • Physiological relevance of TERT overexpression bypass unclear
  10. 2017 Medium

    Expanded WRAP53β to a deubiquitination/stabilization hub in cancer, showing it interacts with USP7 to stabilize Mdm2 and p53 and with UHRF1 to protect it from proteolysis.

    Evidence Co-IP, co-localization, ubiquitination assays, knockdown/overexpression, and half-life measurements in NSCLC cells

    PMID:28406480 PMID:29516630

    Open questions at the time
    • Single-lab Co-IP studies without reciprocal structural validation
    • Whether stabilization is direct or chaperone-mediated is unresolved
  11. 2017 Medium

    Demonstrated an evolutionarily conserved neuronal partnership between WDR79 and SMN, showing reciprocal genetic rescue of locomotion defects.

    Evidence Genetic epistasis and overexpression rescue with locomotion assays in Drosophila and C. elegans

    PMID:28502804

    Open questions at the time
    • Does not identify the molecular pathway underlying the neuronal phenotype
    • Not validated in mammalian neurons
  12. 2018 High

    Revealed a catalytic-activation mechanism, showing TCAB1 controls the hTR CR4/5 conformation as an activity switch independent of telomerase assembly.

    Evidence TCAB1 knockout, RNA structural probing, telomerase activity and hTR-TERT association assays, and CR4/5 mutagenesis

    PMID:29804836

    Open questions at the time
    • Structural mechanism by which TCAB1 stabilizes CR4/5 not visualized
    • Whether other scaRNAs are similarly regulated unknown
  13. 2020 Medium

    Confirmed disease causation through biallelic HHS mutations and tied all three core protein functions (telomere elongation, Cajal bodies, DSB repair) to TRiC-dependent folding.

    Evidence Patient mutation characterization with stability/localization, TRiC interaction, telomere, and DSB repair assays

    PMID:32303682

    Open questions at the time
    • Single-patient/single-lab characterization
    • Does not separate which defects are primary versus secondary to misfolding
  14. 2020 Medium

    Established a stress-induced DNA repair role, showing ROS-driven WRAP53 nuclear translocation promotes DSB repair in neurons during ischemia.

    Evidence OGD neuronal model, ROS measurement, live-cell translocation imaging, DSB repair assays, and an in vivo mouse stroke model

    PMID:33028529

    Open questions at the time
    • Molecular signal driving translocation not defined
    • Repair pathway WRAP53 engages at breaks unidentified
  15. 2021 Medium

    Linked TCAB1 to senescence control, showing its knockdown stabilizes p21 by reducing proteasomal degradation to drive cancer cell senescence.

    Evidence siRNA knockdown, SA-β-galactosidase staining, ubiquitination IP assay, and p21/TCAB1 rescue experiments

    PMID:33413389

    Open questions at the time
    • Whether the effect on p21 ubiquitination is direct is unresolved
    • Single-lab study
  16. 2023 Medium

    Refined the trafficking mechanism, showing TCAB1 retains telomerase RNA in the nucleoplasm to prevent nucleolar sequestration and enable TERT-TR assembly.

    Evidence TCAB1 knockout, cellular fractionation, fluorescence imaging, and telomerase assembly assays

    PMID:37267110

    Open questions at the time
    • Mechanism of nucleolar TR retention in TCAB1 absence not defined
    • Single-lab study
  17. 2025 Medium

    Placed WRAP53 transcript abundance under m6A control, showing ALKBH5 demethylation destabilizes WRAP53 and links it to USP6-RALBP1 and PI3K/Akt/mTOR signaling.

    Evidence m6A mapping, ALKBH5 knockdown/overexpression, stability/translation assays, USP6-RALBP1 Co-IP, and pathway signaling assays

    PMID:39815301

    Open questions at the time
    • Whether the WRAP53 protein or RNA isoform mediates the USP6-RALBP1 effect is unclear
    • Single-lab study

Open questions

Synthesis pass · forward-looking unresolved questions
  • How WRAP53β physically discriminates and chaperones its diverse RNA cargoes and protein partners, and the structural basis for CR4/5 conformational control, remain unresolved.
  • No high-resolution structure of WRAP53β bound to hTR or scaRNAs
  • Determinants distinguishing telomere-recruitment from Cajal-body scaffolding not defined
  • Mechanistic basis of deubiquitinase/ubiquitination effects on USP7, UHRF1, p21 unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 5 GO:0060090 molecular adaptor activity 3 GO:0044183 protein folding chaperone 1
Localization
GO:0005634 nucleus 3 GO:0005730 nucleolus 3 GO:0005654 nucleoplasm 2
Pathway
R-HSA-1640170 Cell Cycle 4 R-HSA-392499 Metabolism of proteins 3 R-HSA-8953854 Metabolism of RNA 3 R-HSA-73894 DNA Repair 2
Partners
CCT/TRICCOILINHTRIMPORTIN-ΒSMNTERTUHRF1USP7
Complex memberships
Cajal bodySMN complextelomerase RNP

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2009 Wrap53 (antisense transcript) regulates endogenous p53 mRNA levels and is required for p53 induction upon DNA damage by targeting the 5' UTR of p53 mRNA; blocking potential Wrap53/p53 RNA hybrids reduces p53 levels, demonstrating regulation via direct RNA-RNA interaction. siRNA knockdown, overexpression, blocking of RNA hybrids, RT-PCR/immunoblot Molecular cell High 19250907
2010 WRAP53 protein (WDR79/TCAB1) is essential for Cajal body maintenance and formation; it associates with coilin, SMN, and importin-β, mediates SMN-coilin and SMN-importin-β complex formation, and is required for nuclear import and Cajal body targeting of the SMN complex. RNAi knockdown, immunofluorescence, co-immunoprecipitation PLoS biology High 21072240
2011 Disruption of TCAB1 (WRAP53β) by missense mutations in dyskeratosis congenita patients misdirects telomerase RNA (hTR) from Cajal bodies to nucleoli, preventing telomerase from elongating telomeres. Patient mutation identification, cellular localization assays (fluorescence imaging), telomere length analysis Genes & development High 21205863
2011 WRAP53 protein knockdown triggers apoptosis through the mitochondrial pathway (Bax/Bak activation, loss of mitochondrial membrane potential, cytochrome c release), demonstrating WRAP53 protein is required for cancer cell survival via mitochondrial apoptosis suppression. siRNA knockdown, flow cytometry, Bax/Bak activation assay, mitochondrial membrane potential assay, cytochrome c release, Bcl-2 rescue Cell death & disease Medium 21368886
2012 TCAB1 is required for telomerase recruitment to telomeres independently of Cajal body integrity; TCAB1 itself localizes to telomeres in a telomerase-dependent but Cajal body-independent manner, demonstrating a direct transport role for TCAB1 beyond Cajal body scaffolding. Coilin depletion (genetic), TCAB1 knockdown, telomerase overexpression rescue assays, fluorescence localization, hTERT point mutation analysis Molecular and cellular biology High 22547674
2012 WDR79 (WRAP53β) binds CAB boxes (UGAG motifs) in the 3' hairpin of intron-encoded AluACA RNAs in a cumulative fashion; AluACA RNPs associate with H/ACA core proteins and accumulate in the nucleoplasm rather than Cajal bodies. Co-immunoprecipitation, RNA co-IP, mutation analysis of CAB boxes, cellular fractionation/fluorescence Genes & development Medium 22892240
2014 CTCF binds Wrap53 RNA directly through a dedicated RNA-binding region (RBR) distinct from its DNA-binding domain; this interaction regulates p53 expression. Depletion of CTCF reduces Wrap53 RNA levels, and a CTCF RBR mutant causes a defective p53 DNA damage response. PAR-CLIP-seq, CTCF depletion, RBR mutagenesis, reporter assays, immunoprecipitation Genes & development High 24696455
2014 The chaperonin CCT/TRiC is required for proper folding of TCAB1; TRiC depletion causes loss of TCAB1 protein, mislocalization of telomerase and scaRNAs to nucleoli, and failure of telomere elongation. DC patient-derived mutations in TCAB1 impair TRiC-mediated folding. Genome-wide siRNA screen (high-content imaging), TRiC depletion, co-immunoprecipitation, telomere elongation assay, patient mutation functional analysis Cell High 25467444
2016 Minimized hTR (binding sites for TERT only) maintains telomeres even in TCAB1 knockout or Coilin knockout cells, demonstrating that TCAB1 and Cajal bodies are dispensable for telomere maintenance when TERT is overexpressed, but wild-type hTR shows distinct changes in telomerase action without TCAB1. CRISPR knockout (TCAB1, Coilin), minimized hTR expression, telomere length and elongation assays eLife High 27525486
2017 WDR79 (WRAP53β) colocalized and physically interacted with USP7 in the nucleus of NSCLC cells; this interaction reduced ubiquitination of Mdm2 and p53, increasing their stability and extending their half-life, thereby promoting cell proliferation via the Mdm2-p53 pathway. Co-immunoprecipitation, co-localization (immunofluorescence), ubiquitination assays, USP7 knockdown, half-life measurement Cell death & disease Medium 28406480
2017 WDR79 (WRAP53β) physically interacts with and stabilizes UHRF1 in the nucleus by protecting it from poly-ubiquitination-mediated proteolysis, thereby promoting NSCLC cell proliferation. Co-immunoprecipitation, co-localization, ubiquitination assay, WDR79 knockdown/overexpression, rescue experiments Journal of cellular and molecular medicine Medium 29516630
2017 WDR79/TCAB1 depletion in Drosophila and C. elegans causes locomotion defects similar to SMN depletion; SMN overexpression rescues WDR79 loss-of-function phenotype in flies, and WDR79 overexpression ameliorates locomotion defects from SMN depletion, demonstrating cooperative, evolutionarily conserved function in the nervous system. Genetic epistasis (overexpression rescue), locomotion assays in Drosophila and C. elegans, RNAi/genetic depletion Neurobiology of disease Medium 28502804
2018 TCAB1 controls the conformation of the CR4/5 domain of hTR; loss of TCAB1 causes unfolding of CR4/5 helices required for catalysis and TERT association, reducing telomerase catalytic activity without affecting enzyme assembly, revealing a conformational 'activity switch' in telomerase RNA. TCAB1 knockout/depletion, RNA structural probing, telomerase activity assay, hTR-TERT association assay, CR4/5 mutagenesis Cell High 29804836
2020 Biallelic WRAP53β mutations (L283F, R398W) in a HHS patient cause destabilization, mislocalization, and faulty interactions of WRAP53β due to misfolding by the TRiC chaperonin; these mutants cannot elongate telomeres, maintain Cajal bodies, or repair DNA double-strand breaks. Patient mutation characterization, protein stability/localization assays, TRiC interaction assays, telomere elongation assay, DNA DSB repair assay Cell death & disease Medium 32303682
2020 Oxygen/glucose deprivation triggers reactive oxygen species that induce DNA double-strand breaks and cause WRAP53 to translocate to the nucleus in neurons, where it promotes DSB repair; this was confirmed in a mouse model of stroke. OGD neuronal model, ROS measurement, live-cell imaging of WRAP53 translocation, DSB repair assays, in vivo mouse stroke model Science advances Medium 33028529
2021 TCAB1 knockdown induces cellular senescence in cancer cells by reducing proteasomal degradation of p21 via regulation of p21 ubiquitination, without affecting p21 mRNA levels; restoring p21 depletion or TCAB1 re-expression rescues the senescence phenotype. siRNA knockdown, SA-β-galactosidase staining, immunoprecipitation ubiquitination assay, qRT-PCR/western blot, rescue experiments Cancer cell international Medium 33413389
2023 In the absence of TCAB1, a large fraction of telomerase RNA (TR) is tightly bound to the nucleolus while TERT is largely excluded from the nucleolus, reducing telomerase assembly; TCAB1 retains TR in the nucleoplasm to prevent sequestration in the nucleolus and enable TERT-TR assembly. TCAB1 knockout, cellular fractionation, fluorescence imaging, telomerase assembly assays Cell reports Medium 37267110
2025 ALKBH5-mediated m6A demethylation of 5' uncapped and polyadenylated WRAP53 transcripts decreases WRAP53 stability and translation efficiency; reduced WRAP53 disrupts the interaction between USP6 and RALBP1, promoting RALBP1 degradation and suppressing PI3K/Akt/mTOR signaling. m6A modification mapping, ALKBH5 knockdown/overexpression, WRAP53 stability/translation assays, Co-IP (USP6-RALBP1), pathway signaling assays Molecular cancer Medium 39815301

Source papers

Stage 0 corpus · 46 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage. Molecular cell 224 19250907
2011 Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita. Genes & development 203 21205863
2014 CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53. Genes & development 176 24696455
2014 Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. Cell 125 25467444
2010 WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies. PLoS biology 113 21072240
2012 Telomerase recruitment requires both TCAB1 and Cajal bodies independently. Molecular and cellular biology 107 22547674
2018 An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1. Cell 65 29804836
2009 TCAB1: driving telomerase to Cajal bodies. Cell cycle (Georgetown, Tex.) 53 19342896
2011 WRAP53 promotes cancer cell survival and is a potential target for cancer therapy. Cell death & disease 51 21368886
2016 Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies. eLife 46 27525486
2012 Human intron-encoded Alu RNAs are processed and packaged into Wdr79-associated nucleoplasmic box H/ACA RNPs. Genes & development 44 22892240
2007 Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer. International journal of cancer 44 17683073
2009 Wrap53, a novel regulator of p53. Cell cycle (Georgetown, Tex.) 40 19571673
2023 TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly. Cell reports 33 37267110
2014 TCAB1: a potential target for diagnosis and therapy of head and neck carcinomas. Molecular cancer 31 25070141
2020 Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal-Hreidarsson syndrome. Cell death & disease 30 32303682
2014 Overexpression of WRAP53 is associated with development and progression of esophageal squamous cell carcinoma. PloS one 29 24626331
2017 WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway. Cell death & disease 28 28406480
2020 Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke. Science advances 22 33028529
2025 ALKBH5 suppresses gastric cancer tumorigenesis and metastasis by inhibiting the translation of uncapped WRAP53 RNA isoforms in an m6A-dependent manner. Molecular cancer 19 39815301
2013 Overlapping region of p53/wrap53 transcripts: mutational analysis and sequence similarity with microRNA-4732-5p. Asian Pacific journal of cancer prevention : APJCP 18 23886136
2017 WDR79/TCAB1 plays a conserved role in the control of locomotion and ameliorates phenotypic defects in SMA models. Neurobiology of disease 17 28502804
2017 Epstein-Barr virus-induced up-regulation of TCAB1 is involved in the DNA damage response in nasopharyngeal carcinoma. Scientific reports 16 28607398
2018 WDR79 mediates the proliferation of non-small cell lung cancer cells by regulating the stability of UHRF1. Journal of cellular and molecular medicine 15 29516630
2016 Overexpression of WDR79 in non-small cell lung cancer is linked to tumour progression. Journal of cellular and molecular medicine 15 26849396
2018 A unique homozygous WRAP53 Arg298Trp mutation underlies dyskeratosis congenita in a Chinese Han family. BMC medical genetics 14 29514627
2011 Cisplatin induces apoptosis via upregulating Wrap53 in U-2OS osteosarcoma cells. Asian Pacific journal of cancer prevention : APJCP 12 22471498
2019 Haplotype and linkage disequilibrium of TP53-WRAP53 locus in Iranian-Azeri women with breast cancer. PloS one 10 31387111
2017 Clinical, cellular, and bioinformatic analyses reveal involvement of WRAP53 overexpression in carcinogenesis of lung adenocarcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 10 28347242
2022 The Role of WRAP53 in Cell Homeostasis and Carcinogenesis Onset. Current issues in molecular biology 9 36354684
2018 Oncogenic Activity of Wrap53 in Human Colorectal Cancer In Vitro and in Nude Mouse Xenografts. Medical science monitor : international medical journal of experimental and clinical research 9 30175821
2015 Regulatory effects of WRAP53 on radiosensitivity of laryngeal squamous cell carcinoma cells. Asian Pacific journal of cancer prevention : APJCP 9 25854392
2021 Suppression of TCAB1 expression induced cellular senescence by lessening proteasomal degradation of p21 in cancer cells. Cancer cell international 7 33413389
2023 Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors. PloS one 6 36706151
2023 The role of UCA1 and WRAP53 in diagnosis of hepatocellular carcinoma: A single-center case-control study. Clinical and experimental hepatology 6 37502440
2011 A bidirectional promoter reporter vector for the analysis of the p53/WDR79 dual regulatory element. Plasmid 6 21924287
2009 The diversity profile of TP53 is influenced by positive selection on the immediately upstream locus WDR79. Human heredity 6 19797907
2016 Association between the WRAP53 gene rs2287499 C>G polymorphism and cancer risk: A meta-analysis. Genetics and molecular research : GMR 4 27525856
2023 Selenomethionine suppresses head and neck squamous cell carcinoma progression through TopBP1/ATR and TCAB1 signaling. Histology and histopathology 2 37750664
2026 TCAB1: a key promoter of tumor growth through telomere maintenance and senescence evasion. Cell cycle (Georgetown, Tex.) 1 41489261
2026 WRAP53 is Downregulated in Acute Myeloid Leukemia Patients and Positively Correlates With HTERT Expression. Cancer reports (Hoboken, N.J.) 1 41656604
2023 WDR79 promotes aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) by the suppression of SIRT4. Open medicine (Warsaw, Poland) 1 36712589
2026 Functional inactivation of the telomerase chaperone TCAB1 primes cells for the activation of ALT in osteosarcoma. bioRxiv : the preprint server for biology 0 41509329
2026 Complex structural variations functionally inactivate the telomerase chaperone TCAB1 in osteosarcoma. BMC cancer 0 42243724
2022 Next-generation sequencing errors due to genetic variation in WRAP53 encoding TCAB1 on chromosome 17. Human mutation 0 36116037
2021 Diaphyseal and Metaphyseal Modeling Defects-Clinical Findings and Identification of WRAP53 Deficiency in Craniometadiaphyseal Dysplasia. Frontiers in genetics 0 34484289

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