- Length
- 565 aa
- Mass
- 65.4 kDa
- Annotated
- 2026-06-14
89 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 89 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 1994 | The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. | Genes & development | 427 | 7958905 |
| 1995 | The product of the spindle formation gene sad1+ associates with the fission yeast spindle pole body and is essential for viability. | The Journal of cell biology | 360 | 7744953 |
| 2007 | Telomere anchoring at the nuclear periphery requires the budding yeast Sad1-UNC-84 domain protein Mps3. | The Journal of cell biology | 155 | 18039933 |
| 2001 | The SAD-1 kinase regulates presynaptic vesicle clustering and axon termination. | Neuron | 150 | 11182085 |
| 2021 | Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma. | Cell death and differentiation | 135 | 33649471 |
| 2011 | Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope. | The Journal of biological chemistry | 115 | 22170055 |
| 2006 | The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope. | The Journal of cell biology | 114 | 16923827 |
| 2024 | Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K/AKT/HIF-1α signal pathway in endometrial carcinoma. | Cell death discovery | 103 | 38459014 |
| 2008 | Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B. | Cell cycle (Georgetown, Tex.) | 102 | 18728397 |
| 2003 | Two-hybrid search for proteins that interact with Sad1 and Kms1, two membrane-bound components of the spindle pole body in fission yeast. | Molecular genetics and genomics : MGG | 89 | 14655046 |
| 2006 | SAD-2 is required for meiotic silencing by unpaired DNA and perinuclear localization of SAD-1 RNA-directed RNA polymerase. | Proceedings of the National Academy of Sciences of the United States of America | 78 | 16461906 |
| 2019 | USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2. | Cancer letters | 60 | 30771428 |
| 2006 | Neuronal polarity is regulated by a direct interaction between a scaffolding protein, Neurabin, and a presynaptic SAD-1 kinase in Caenorhabditis elegans. | Development (Cambridge, England) | 60 | 17151015 |
| 2023 | USP39 stabilizes β-catenin by deubiquitination and suppressing E3 ligase TRIM26 pre-mRNA maturation to promote HCC progression. | Cell death & disease | 52 | 36707504 |
| 2021 | Splicing factor USP39 promotes ovarian cancer malignancy through maintaining efficient splicing of oncogenic HMGA2. | Cell death & disease | 51 | 33731694 |
| 2019 | RNA splicing factor USP39 promotes glioma progression by inducing TAZ mRNA maturation. | Oncogene | 50 | 31332287 |
| 2004 | Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. | The Journal of biological chemistry | 46 | 15150265 |
| 2005 | Validation of a cotton-specific gene, Sad1, used as an endogenous reference gene in qualitative and real-time quantitative PCR detection of transgenic cottons. | Plant cell reports | 44 | 15726375 |
| 2021 | USP39 promotes tumorigenesis by stabilizing and deubiquitinating SP1 protein in hepatocellular carcinoma. | Cellular signalling | 43 | 34197957 |
| 2011 | Zebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansion. | PLoS genetics | 43 | 21249182 |
| 2017 | USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer. | The Journal of biological chemistry | 42 | 28154181 |
| 2013 | Lentivirus-mediated inhibition of USP39 suppresses the growth of breast cancer cells in vitro. | Oncology reports | 42 | 24126978 |
| 2017 | USP39 promotes colorectal cancer growth and metastasis through the Wnt/β-catenin pathway. | Oncology reports | 39 | 28259917 |
| 2020 | An NAD+-Dependent Deacetylase SIRT7 Promotes HCC Development Through Deacetylation of USP39. | iScience | 38 | 32711345 |
| 2015 | USP39 promotes the growth of human hepatocellular carcinoma in vitro and in vivo. | Oncology reports | 38 | 26081192 |
| 2014 | The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing. | RNA (New York, N.Y.) | 36 | 24681967 |
| 2020 | USP39 Serves as a Deubiquitinase to Stabilize STAT1 and Sustains Type I IFN-Induced Antiviral Immunity. | Journal of immunology (Baltimore, Md. : 1950) | 34 | 33127822 |
| 2022 | USP39 facilitates breast cancer cell proliferation through stabilization of FOXM1. | American journal of cancer research | 33 | 36119839 |
| 2013 | Sad1 counteracts Brr2-mediated dissociation of U4/U6.U5 in tri-snRNP homeostasis. | Molecular and cellular biology | 32 | 24190974 |
| 2020 | Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway. | International journal of molecular sciences | 31 | 33255748 |
| 2016 | Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | 31 | 27456357 |
| 2008 | A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation. | Neural development | 31 | 18808695 |
| 2017 | USP39, a direct target of microRNA-133a, promotes progression of pancreatic cancer via the AKT pathway. | Biochemical and biophysical research communications | 30 | 28286270 |
| 2021 | USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A165b alternative splicing via regulating SRSF1 and SRPK1. | Cancer cell international | 29 | 34544400 |
| 2014 | SAD1, an RNA polymerase I subunit A34.5 of rice, interacts with Mediator and controls various aspects of plant development. | The Plant journal : for cell and molecular biology | 29 | 25404280 |
| 2019 | USP39 promotes ovarian cancer malignant phenotypes and carboplatin chemoresistance. | International journal of oncology | 28 | 31180526 |
| 2018 | MiR-1281, a p53-responsive microRNA, impairs the survival of human osteosarcoma cells upon ER stress via targeting USP39. | American journal of cancer research | 28 | 30323969 |
| 2023 | USP39 Regulates NF-κB-Mediated Inflammatory Responses through Deubiquitinating K48-Linked IκBα. | Journal of immunology (Baltimore, Md. : 1950) | 26 | 36651806 |
| 2021 | USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing. | Nucleic acids research | 26 | 34614178 |
| 2021 | USP39 mediates p21-dependent proliferation and neoplasia of colon cancer cells by regulating the p53/p21/CDC2/cyclin B1 axis. | Molecular carcinogenesis | 25 | 33634905 |
| 2015 | Reduced USP39 expression inhibits malignant proliferation of medullary thyroid carcinoma in vitro. | World journal of surgical oncology | 25 | 26303214 |
| 2021 | USP39 attenuates the antitumor activity of cisplatin on colon cancer cells dependent on p53. | Cell biology and toxicology | 24 | 34822033 |
| 2014 | Membrane-associated proteomics of chickpea identifies Sad1/UNC-84 protein (CaSUN1), a novel component of dehydration signaling. | Scientific reports | 21 | 24577507 |
| 2023 | USP39 interacts with SIRT7 to promote cervical squamous cell carcinoma by modulating autophagy and oxidative stress via FOXM1. | Journal of translational medicine | 20 | 37957720 |
| 2016 | Lentivirus-mediated inhibition of USP39 suppresses the growth of gastric cancer cells via PARP activation. | Molecular medicine reports | 20 | 27175747 |
| 2019 | USP39 regulates the cell cycle, survival, and growth of human leukemia cells. | Bioscience reports | 19 | 30898977 |
| 2023 | Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of autophagy. | Nature communications | 18 | 37923718 |
| 2015 | Lentiviral vector-mediated doxycycline-inducible USP39 shRNA or cDNA expression in triple-negative breast cancer cells. | Oncology reports | 18 | 25812575 |
| 2022 | DNAAF5 promotes hepatocellular carcinoma malignant progression by recruiting USP39 to improve PFKL protein stability. | Frontiers in oncology | 17 | 36276075 |
| 2022 | The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement. | Cell reports | 16 | 35139388 |
| 2018 | Sad1 Spatiotemporally Regulates Kinetochore Clustering To Ensure High-Fidelity Chromosome Segregation in the Human Fungal Pathogen Cryptococcus neoformans. | mSphere | 16 | 29976642 |
| 2023 | USP39-mediated deubiquitination of Cyclin B1 promotes tumor cell proliferation and glioma progression. | Translational oncology | 15 | 37302347 |
| 2021 | The Deubiquitinase USP39 Promotes ESCC Tumorigenesis Through Pre-mRNA Splicing of the mTORC2 Component Rictor. | Frontiers in oncology | 15 | 34123832 |
| 2019 | Exome sequencing study of Russian breast cancer patients suggests a predisposing role for USP39. | Breast cancer research and treatment | 15 | 31754952 |
| 2017 | USP39 regulates the growth of SMMC-7721 cells via FoxM1. | Experimental and therapeutic medicine | 15 | 28413501 |
| 2010 | SunB, a novel Sad1 and UNC-84 domain-containing protein required for development of Dictyostelium discoideum. | Development, growth & differentiation | 14 | 20887559 |
| 2022 | The Deubiquitinase USP39 Promotes Esophageal Squamous Cell Carcinoma Malignancy as a Splicing Factor. | Genes | 13 | 35627203 |
| 2023 | SAD-1 kinase controls presynaptic phase separation by relieving SYD-2/Liprin-α autoinhibition. | PLoS biology | 12 | 38048304 |
| 2016 | Knockdown of USP39 by lentivirus-mediated RNA interference suppresses the growth of oral squamous cell carcinoma. | Cancer biomarkers : section A of Disease markers | 12 | 26835714 |
| 2023 | Deubiquitinase USP39 promotes SARS-CoV-2 replication by deubiquitinating and stabilizing the envelope protein. | Antiviral research | 11 | 38158131 |
| 2022 | miR-381 Inhibits Proliferation and Invasion of Non-Small-Cell Cancer Cells by Targeting USP39. | Disease markers | 11 | 36046375 |
| 2024 | Deubiquitinating enzyme USP39 promotes the growth and metastasis of gastric cancer cells by modulating the degradation of RNA-binding protein RBM39. | The Journal of biological chemistry | 10 | 39260689 |
| 2022 | USP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components. | Communications biology | 10 | 35440748 |
| 2025 | USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expression. | Cell communication and signaling : CCS | 6 | 39885503 |
| 2024 | Disrupting USP39 deubiquitinase function impairs the survival and migration of multiple myeloma cells through ZEB1 degradation. | Journal of experimental & clinical cancer research : CR | 6 | 39736693 |
| 2020 | Elevated Sad1 and UNC84 Domain Containing 2 (SUN2) level inhibits cell growth and aerobic glycolysis in oral cancer through reducing the expressions of glucose transporter 1 (GLUT1) and lactate dehydrogenase A (LDHA). | Journal of dental sciences | 6 | 33384835 |
| 2010 | The long and the short of SAD-1 kinase. | Communicative & integrative biology | 5 | 20714407 |
| 2025 | Toosendanin promotes prostate cancer cell apoptosis, ferroptosis and M1 polarization via USP39-mediated PLK1 deubiquitination. | Naunyn-Schmiedeberg's archives of pharmacology | 4 | 40056202 |
| 2024 | USP39 Promotes the Viability and Migration of Head and Neck Squamous Cell Carcinoma Cell by Regulating STAT1. | Technology in cancer research & treatment | 4 | 38706215 |
| 2024 | USP39 regulates pyruvate handling in non-small cell lung cancer. | Cell death discovery | 4 | 39695108 |
| 2023 | USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear Localization and Activity. | Biomolecules | 4 | 37892157 |
| 2025 | USP39 promote post-translational modifiers to stimulate the progress of cancer. | Discover oncology | 3 | 40358671 |
| 2024 | The SUN-family protein Sad1 mediates heterochromatin spatial organization through interaction with histone H2A-H2B. | Nature communications | 3 | 38773107 |
| 2025 | Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation. | Angewandte Chemie (International ed. in English) | 2 | 41423877 |
| 2018 | Loop-Mediated Isothermal Amplification for Detection of Endogenous Sad1 Gene in Cotton: An Internal Control for Rapid Onsite GMO Testing. | Journal of AOAC International | 2 | 29678222 |
| 2026 | USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration. | Journal of orthopaedic translation | 1 | 41836548 |
| 2025 | USP39/SMC4 promotes hepatoma cell proliferation and 5-FU resistance. | Scientific reports | 1 | 40087331 |
| 2025 | MYC-Driven Activation of USP39 Enhances SRSF1 Stability and Promotes PDAC Progression. | bioRxiv : the preprint server for biology | 1 | 40909523 |
| 2026 | Dual roles of USP39 in stabilizing PB2 and orchestrating ribonucleoprotein assembly drive H5 influenza virus replication and pathogenicity. | Cell reports | 0 | 41712380 |
| 2026 | USP39 deubiquitinase: Dual roles in RNA splicing and protein stabilization in cancer therapeutics. | International journal of biological macromolecules | 0 | 41903639 |
| 2026 | USP39 promotes antiviral defense through post-transcriptional control of RIG-I and stabilization of STING. | PLoS biology | 0 | 42113893 |
| 2026 | USP39 reduces BRCA1 methylation to promote mitochondrial biogenesis and lower drug sensitivity in ovarian cancer through deubiquitinating ZC3H18. | 3 Biotech | 0 | 42205906 |
| 2025 | USP39 promotes retinal pathological angiogenesis in retinopathy of prematurity by stabilizing SIRT2 expression through deubiquitination. | International ophthalmology | 0 | 39853525 |
| 2025 | Exploring the cancerous nexus: the pivotal and diverse roles of USP39 in cancer development. | Discover oncology | 0 | 40347416 |
| 2025 | USP39 Depletion Plays Repressive Roles in Laryngeal Squamous Cell Carcinoma Development. | Cell biology international | 0 | 40405439 |
| 2025 | USP39 at the crossroads of cancer immunity: regulating immune evasion and immunotherapy response through RNA splicing and ubiquitin signaling. | Frontiers in immunology | 0 | 40990019 |
| 2025 | Astaxanthin inhibits hepatocellular carcinoma by targeting USP39-mediated β-catenin stabilization through deubiquitination. | Scientific reports | 0 | 41238805 |
| 2023 | SAD-1 kinase controls presynaptic phase separation by relieving SYD-2/Liprin-α autoinhibition. | bioRxiv : the preprint server for biology | 0 | 37398223 |
| 2013 | Preliminary crystallographic analysis of the kinase domain of SAD-1, a protein essential for presynaptic differentiation in Caenorhabditis elegans. | Acta crystallographica. Section F, Structural biology and crystallization communications | 0 | 23545657 |
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