Affinage

USP26

Ubiquitin carboxyl-terminal hydrolase 26 · UniProt Q9BXU7

Length
913 aa
Mass
104.0 kDa
Annotated
2026-04-28
45 papers in source corpus 24 papers cited in narrative 23 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

USP26 is an X-linked deubiquitinating enzyme with broad substrate range that functions in male meiosis, DNA damage repair, TGF-β signaling, and multiple oncogenic pathways. In the testis, USP26 localizes to the XY body during meiosis and stabilizes TEX11, ensuring proper sex chromosome pairing; its loss causes meiotic defects, XY aneuploidy, and male subfertility/sterility (PMID:33978233, PMID:31551464). At DNA double-strand breaks, USP26 counteracts RNF168-dependent ubiquitin conjugates to limit RAP80-BRCA1 spreading and promote PALB2-dependent homologous recombination (PMID:26101254); in signaling contexts it deubiquitinates and stabilizes diverse substrates including SMAD7 (attenuating TGF-β signaling) (PMID:28381482), CBX4/CBX6 (suppressing somatic reprogramming via PRC1) (PMID:28839133), AR (PMID:20501646), TAZ (PMID:35397626), SIRT1 (PMID:39251623), PRKN (PMID:38565942), BAG3 (PMID:38880224), and TRAF3 (suppressing type I interferon signaling by removing K63-linked ubiquitin) (PMID:39058724). USP26 activity is itself regulated by Tip60-mediated acetylation at K134, which enhances substrate binding (PMID:38880224), and its transcription is induced by HIF-1α, HBx, TGF-β, and the RNF12-REX1 axis, establishing feed-forward regulatory circuits in germ cell differentiation and disease (PMID:39377219, PMID:39251623, PMID:35857630).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2010 High

    Identifying USP26 as a nuclear DUB that directly binds and deubiquitinates AR established its first known enzymatic substrate and placed it within androgen signaling in the testis.

    Evidence shRNA screen, Co-IP, ubiquitination assay in mammalian cells

    PMID:20501646

    Open questions at the time
    • No in vivo confirmation of AR stabilization by USP26
    • Structural basis of NR-box–AR interaction not resolved
  2. 2014 Medium

    Demonstrating USP26–AR co-localization in Leydig cell nuclei of human testis confirmed physiological relevance of the USP26–AR interaction identified in cell lines.

    Evidence Immunofluorescence co-localization and immunohistochemistry on human testis tissue arrays

    PMID:24922532

    Open questions at the time
    • No functional readout in primary human tissue
    • Expression in other testicular cell types not linked to specific substrates
  3. 2015 High

    Revealing that USP26 counteracts RNF168-induced ubiquitin at DSBs to restrict RAP80-BRCA1 spreading and promote HR expanded USP26 function beyond hormone signaling into the DNA damage response.

    Evidence Genetic screen, laser micro-irradiation, epistasis with RAP80 depletion, HR reporter assay

    PMID:26101254

    Open questions at the time
    • Direct deubiquitination of specific histone marks at DSBs not demonstrated biochemically
    • Contribution relative to other DSB-associated DUBs not quantified
  4. 2016 Medium

    Identification of Mdm2 as a USP26 substrate and characterization of the R344W mutation's impact on AR deubiquitination began defining USP26's substrate diversity and catalytic requirements.

    Evidence Co-IP, cell-free ubiquitination assay, site-directed mutagenesis with reporter assays

    PMID:27089915 PMID:27810359

    Open questions at the time
    • Mdm2 stabilization not tested in vivo
    • Functional consequence of R344W on spermatogenesis not established in animal model
  5. 2017 High

    Discovery that USP26 stabilizes SMAD7 to dampen TGF-β signaling, stabilizes CBX4/CBX6 to suppress reprogramming, and that Q156H abolishes catalytic activity established USP26 as a multi-pathway regulator and refined enzymatic mechanism.

    Evidence Co-IP, K48-linkage-specific ubiquitination assay, reprogramming efficiency assay, ChIP, in vitro cleavage assay with mutagenesis

    PMID:28381482 PMID:28839133 PMID:29111204

    Open questions at the time
    • Structural basis for substrate selectivity among diverse targets unknown
    • In vivo TGF-β regulation by USP26 not tested in knockout model
  6. 2019 High

    Usp26 knockout mice revealed essential roles in meiotic chromosome synapsis and chiasma formation, providing the first genetic evidence that USP26 is required for male fertility.

    Evidence Gene-targeted mouse (DBA/2 background), histology, cytological analysis of spermatocytes

    PMID:31551464

    Open questions at the time
    • Molecular substrate mediating synapsis defect not identified in this study
    • Background-dependent penetrance mechanism unknown
  7. 2019 Medium

    Identification of Snail as a USP26 substrate linked USP26 to epithelial–mesenchymal transition and cancer cell invasion.

    Evidence DUB library screen, Co-IP, ubiquitination assay, migration/invasion assay

    PMID:30763716

    Open questions at the time
    • In vivo relevance of USP26–Snail axis in metastasis not shown
    • Ubiquitin chain linkage type not specified
  8. 2020 Medium

    Placing USP26 downstream of RAC1B in a RAC1B→USP26→SMAD7 axis reinforced the TGF-β dampening model and revealed transcriptional regulation of USP26 in carcinoma cells.

    Evidence RNAi epistasis, rescue experiments, migration assay in mesenchymal carcinoma cells

    PMID:32545415

    Open questions at the time
    • RAC1B-mediated transcriptional regulation of USP26 promoter not mapped
    • Generalizability beyond pancreatic carcinoma not tested
  9. 2021 High

    Demonstrating that USP26 localizes to the XY body and stabilizes TEX11 resolved the molecular mechanism underlying the meiotic pairing defect and XY aneuploidy in Usp26 knockout mice.

    Evidence KO mouse, immunofluorescence at XY body, Co-IP with TEX11, sperm FISH, offspring karyotyping

    PMID:33978233

    Open questions at the time
    • Ubiquitin chain type on TEX11 removed by USP26 not specified
    • Whether other XY body proteins are USP26 substrates is unknown
  10. 2022 High

    Discovery of the RNF12→REX1→USP26 feed-forward loop, in which USP26 prevents RNF12 autoubiquitylation, revealed a self-amplifying circuit required for germ cell differentiation.

    Evidence Quantitative proteomics, reciprocal Co-IP, ubiquitination assay, in vitro germ cell differentiation

    PMID:35857630

    Open questions at the time
    • In vivo validation of feed-forward loop in testis not completed
    • Stoichiometry and regulation of USP26–RNF12 complex uncharacterized
  11. 2022 Medium

    Identification of TAZ as a USP26 substrate in anaplastic thyroid cancer extended USP26's oncogenic roles to Hippo pathway regulation.

    Evidence Co-IP, ubiquitination assay, knockdown/rescue, gene expression of TEAD targets

    PMID:35397626

    Open questions at the time
    • In vivo TAZ stabilization by USP26 not demonstrated
    • Whether USP26 affects upstream Hippo kinases unknown
  12. 2024 Medium

    Multiple studies identified PRKN (K129), SIRT1, SIRT2, BAG3, KLF6, and TRAF3 as USP26 substrates, and revealed post-translational (Tip60 acetylation at K134) and transcriptional (HIF-1α, HBx) regulation of USP26, greatly expanding its regulatory network.

    Evidence Co-IP, site-specific mutagenesis, K63-linkage-specific ubiquitination assay, ChIP, KO mouse tumor models, acetylation assay, IFN-β reporter

    PMID:38064851 PMID:38565942 PMID:38880224 PMID:39058724 PMID:39251623 PMID:39377219

    Open questions at the time
    • Many substrate interactions characterized by single labs and need independent replication
    • Structural determinants of substrate selectivity still completely unknown
    • Relative contribution of acetylation vs. transcriptional induction to USP26 activity regulation not compared

Open questions

Synthesis pass · forward-looking unresolved questions
  • A structural model of USP26 explaining its unusually broad substrate specificity, its allosteric regulation by acetylation, and the basis for disease-associated mutations is lacking.
  • No crystal or cryo-EM structure available
  • No unbiased proteomics-based substrate identification across tissues
  • Relative physiological importance of individual substrates in different tissues not ranked

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 14 GO:0016787 hydrolase activity 6
Localization
GO:0005634 nucleus 3 GO:0005694 chromosome 2
Pathway
R-HSA-392499 Metabolism of proteins 12 R-HSA-162582 Signal Transduction 4 R-HSA-1474165 Reproduction 3 R-HSA-1640170 Cell Cycle 1 R-HSA-168256 Immune System 1 R-HSA-73894 DNA Repair 1
Partners
ARCBX4CBX6MDM2RLIMSMAD7TEX11TRAF3
Complex memberships
RNF12-USP26 complex

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 USP26 is a nuclear protein that binds to androgen receptor (AR) via three nuclear receptor interaction motifs, modulates AR ubiquitination, and counteracts hormone-induced AR ubiquitination, thereby stabilizing AR and contributing to AR transcriptional activity. USP26 assembles with AR and other cofactors in subnuclear foci. shRNA library screen, co-immunoprecipitation, ubiquitination assay, immunofluorescence, nuclear fractionation Molecular cancer research : MCR High 20501646
2015 USP26 is recruited to DNA double-strand breaks (DSBs) where it removes RNF168-induced ubiquitin conjugates, limiting the spreading of RAP80-BRCA1 from DSBs, and promoting the association of BRCA1 with PALB2 to facilitate homologous recombination (HR). Depletion of USP26 disrupts HR execution, an effect alleviated by simultaneous depletion of RAP80. Genetic screen, siRNA depletion, laser micro-irradiation/DSB induction, immunofluorescence, epistasis (double knockdown), HR reporter assay Nucleic acids research High 26101254
2017 USP26 deubiquitinates and stabilizes SMAD7, acting as a negative regulator of TGF-β signaling. TGF-β rapidly induces USP26 expression, and USP26 in turn limits ubiquitin-mediated turnover of SMAD7; knockdown of USP26 destabilizes SMAD7, leading to TGF-β receptor stabilization and enhanced p-SMAD2 levels. siRNA knockdown, co-immunoprecipitation, ubiquitination assay, western blot, cycloheximide chase EMBO reports High 28381482
2017 USP26 negatively regulates somatic cell reprogramming by removing K48-linked polyubiquitination from CBX4 and CBX6 (PRC1 complex components), stabilizing them. Accumulated CBX4 and CBX6 repress pluripotency genes Sox2 and Nanog through PRC1-mediated H2A ubiquitination at their promoters. Overexpression, knockdown, co-immunoprecipitation, ubiquitination assay (K48-linkage specific), reprogramming efficiency assay, ChIP Nature communications High 28839133
2019 USP26 deubiquitinates and stabilizes Snail (SNAI1), an EMT transcription factor, promoting cancer cell migration and invasion. Identified via DUB library screen. DUB library screen, co-immunoprecipitation, ubiquitination assay, cycloheximide chase, migration/invasion assay Cancer letters Medium 30763716
2016 USP26 binds to Mdm2 through its coiled-coil C-terminal domain, deubiquitinates Mdm2, and stabilizes it. USP26 itself can be ubiquitinated by HeLa cell extract and has a defined half-life in HEK293 cells. Co-transfection, co-immunoprecipitation, cell-free ubiquitination assay, half-life determination (cycloheximide chase) Biochemical and biophysical research communications Medium 27810359
2016 The USP26 R344W missense mutation reduces binding affinity and deubiquitinating activity of USP26 toward AR, eliminating USP26's inhibitory effect on AR transcriptional activity in HeLa and TM4 cells. Immunoprecipitation, ubiquitination assay, luciferase reporter assay, site-directed mutagenesis Reproductive sciences Medium 27089915
2017 The USP26 Q156H mutant loses deubiquitinase enzymatic activity, while 18 other tested USP26 variants retain wild-type activity. Artificially constructed truncation mutants (E174# and E189# split constructs) also lose activity, demonstrating requirement for intact protein. Site-directed mutagenesis, USP cleavage assay (Ub-Met-β-gal and GST-Ub52 substrates) Gene Medium 29111204
2019 Usp26 mutation in mice (backcrossed to DBA/2 background) causes sterility or subfertility with atrophic testes, reduced spermatid numbers, malformed sperm head morphology, unsynapsed chromosomes in pachynema, and defective chiasma formation in diplonema, leading to apoptosis of metaphase spermatocytes. Mouse knockout (gene targeting), histology, cytological analysis of spermatocytes, fertility assessment Scientific reports High 31551464
2021 USP26 protein localizes at the XY body during male meiosis, and USP26 knockout in male mice results in incomplete sex chromosome pairing by destabilizing TEX11, leading to XY aneuploid spermatozoa and elevated rates of 41,XXY offspring. Knockout mouse model, immunofluorescence (XY body localization), co-immunoprecipitation/interaction with TEX11, sperm FISH for aneuploidy, offspring karyotyping The EMBO journal High 33978233
2022 USP26 is a downstream target of RNF12 (RLIM): RNF12 relieves REX1-mediated repression of Usp26 transcription, leading to increased USP26 abundance. USP26 then forms a complex with RNF12 and prevents RNF12 autoubiquitylation and proteasomal degradation, establishing a transcriptional feed-forward amplification loop required for germ cell differentiation and gametogenesis gene expression. Global quantitative proteomics, co-immunoprecipitation, ubiquitination assay, transcriptional reporter assay, in vitro germ cell differentiation, genetic interaction studies with TOKAS/infertility variants Science signaling High 35857630
2022 USP26 deubiquitinates and stabilizes TAZ (a Hippo pathway effector) in anaplastic thyroid cancer cells, in a deubiquitylation activity-dependent manner, regulating expression of TAZ/TEAD target genes (CTGF, ANKRD1, CYR61) and promoting cancer cell proliferation, migration, and invasion. Co-immunoprecipitation, ubiquitination assay, knockdown/rescue experiments, gene expression analysis, functional assays (proliferation, migration, invasion) Cell death & disease Medium 35397626
2024 USP26 directly interacts with PRKN (Parkin), deubiquitinates it at the K129 site, and reduces its activity, thereby restraining PRKN-mediated mitophagy and promoting colorectal cancer tumorigenesis. A K129R mutation on PRKN diminishes its activation and ability to mediate mitophagy. Co-immunoprecipitation, ubiquitination assay (site-specific mutagenesis K129R), mitophagy assay, knockdown/overexpression with tumor growth readout Oncogene Medium 38565942
2024 HBV-encoded protein HBx induces USP26 expression by binding to the USP26 promoter. USP26 then associates with SIRT1 and stabilizes it by deubiquitination, promoting cell proliferation and impeding apoptosis to drive hepatocellular carcinoma tumorigenesis. sgRNA library screen, Usp26 knockout mouse model (HCC tumorigenesis), co-immunoprecipitation, ubiquitination assay, ChIP (HBx on USP26 promoter) Nature communications High 39251623
2024 USP26 deubiquitinates and stabilizes BAG3 (co-chaperone). The lysine acetyltransferase Tip60 acetylates USP26 at K134, enhancing USP26's binding affinity to BAG3 and promoting BAG3 deubiquitination and protein stability, thereby driving breast cancer progression. Co-immunoprecipitation, ubiquitination assay, acetylation assay, site-directed mutagenesis (K134), in vivo tumor model, structure-based virtual screening Cancer letters Medium 38880224
2024 USP26 physically interacts with TRAF3 and removes K63-linked polyubiquitination from TRAF3, thereby suppressing TRAF3-mediated activation of the MAVS/TBK-1/IRF3 (type I interferon) signaling pathway during antiviral response. Co-immunoprecipitation, ubiquitination assay (K63-linkage specific), siRNA knockdown, IFN-β reporter assay, viral replication assay PloS one Medium 39058724
2024 USP26 deubiquitinates and stabilizes SIRT2; decreased USP26 expression leads to SIRT2 degradation via ubiquitination, causing mitochondrial dysfunction, BMSC senescence, and age-related decline in self-renewal and multipotency. HIF-1α transcriptionally upregulates USP26 by binding to -191 to -198 bp and -262 to -269 bp regions of the USP26 promoter. Knockdown/overexpression, co-immunoprecipitation, ubiquitination assay, ChIP (HIF-1α on USP26 promoter), mitochondrial function assay, BMSC differentiation assay Advanced science Medium 39377219
2020 USP26 co-immunoprecipitates with androgen receptor (AR) in Leydig cells (TM3), influences AR deubiquitination, and upregulates CCND1 and SPATA46 (cell cycle and spermatogenesis factors) while decreasing TP73 expression, promoting Leydig cell G1-G2 transition and proliferation through the AR signaling pathway. Co-immunoprecipitation, immunofluorescence, western blot, flow cytometry (cell cycle), overexpression/inhibition plasmids Advances in clinical and experimental medicine Low 33064378
2020 RAC1B upregulates SMAD7 protein by promoting USP26 transcription; USP26 in turn deubiquitinates SMAD7, stabilizing it and suppressing TGF-β1-induced ALK5 signaling and cell migration in mesenchymal-type carcinoma cells. RNAi knockdown, overexpression/rescue, western blot, transcriptional reporter assay, cell migration assay Cancers Medium 32545415
2023 USP26 interacts with and deubiquitinates KLF6, prolonging KLF6 protein stability. The functional interaction domain was mapped to amino acids 285-913 of USP26. Wild-type but not catalytic mutant USP26 attenuates KLF6 ubiquitination; USP26 overexpression inhibits HeLa cell proliferation and migration. DUB library screen, co-immunoprecipitation (domain mapping), ubiquitination assay, cycloheximide chase, shRNA knockdown, functional cellular assays Computers in biology and medicine Medium 38064851
2025 USP26 deubiquitinates and stabilizes c-Myc by suppressing its polyubiquitination and degradation, promoting aerobic glycolysis and cell proliferation in gastric cancer. Co-immunoprecipitation, ubiquitination assay, shRNA knockdown, functional proliferation/glycolysis assay DNA and cell biology Low 41125405
2025 In osteoblasts, USP26 loss leads to ubiquitin-mediated degradation of IL4I1 (interleukin-4-induced protein 1), reducing production of the tryptophan metabolite indole-3-acetic acid (IAA) and compromising B lymphopoiesis; USP26 deficiency in osteoblasts also decreases H3K18 lactylation at the KSRP promoter, reducing FSTL1 mRNA alternative splicing and elevating FSTL1, causing insulin resistance and multi-organ fibrosis. Osteoblast-specific conditional Usp26 knockout, transcriptomics, targeted metabolomics, in vivo/in vitro supplementation experiments, engineered exosome delivery Journal of advanced research / Advanced science Low 41417635 41687771
2014 USP26 protein is expressed and co-localizes with androgen receptor predominantly in Leydig cell nuclei in human testis, with additional expression in spermatogonia, primary spermatocytes, round spermatids, and Sertoli cells, consistent with a role in regulating AR during spermatogenesis. Immunofluorescence co-localization, immunohistochemistry on human testis tissue arrays, multiplex qRT-PCR PloS one Medium 24922532

Source papers

Stage 0 corpus · 45 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Possible role of USP26 in patients with severely impaired spermatogenesis. European journal of human genetics : EJHG 76 15562280
2010 The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling. Molecular cancer research : MCR 73 20501646
2015 The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80. Nucleic acids research 64 26101254
2017 USP26 regulates TGF-β signaling by deubiquitinating and stabilizing SMAD7. EMBO reports 61 28381482
2019 USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail. Cancer letters 47 30763716
2006 Haplotypes, mutations and male fertility: the story of the testis-specific ubiquitin protease USP26. Molecular human reproduction 36 16888075
2016 A Novel Missense Mutation in USP26 Gene Is Associated With Nonobstructive Azoospermia. Reproductive sciences (Thousand Oaks, Calif.) 33 27089915
2008 USP26 gene variations in fertile and infertile men. Human reproduction (Oxford, England) 32 18927127
2017 USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components. Nature communications 31 28839133
2006 Alterations of the USP26 gene in Caucasian men. International journal of andrology 31 17121659
2013 Ubiquitin-specific protease (USP26) gene alterations associated with male infertility and recurrent pregnancy loss (RPL) in Iranian infertile patients. Journal of assisted reproduction and genetics 29 23779098
2008 Association of USP26 haplotypes in men in Taiwan, China with severe spermatogenic defect. Asian journal of andrology 28 18958354
2022 USP26 promotes anaplastic thyroid cancer progression by stabilizing TAZ. Cell death & disease 27 35397626
2019 Usp26 mutation in mice leads to defective spermatogenesis depending on genetic background. Scientific reports 26 31551464
2014 Ubiquitin Specific Protease 26 (USP26) expression analysis in human testicular and extragonadal tissues indicates diverse action of USP26 in cell differentiation and tumorigenesis. PloS one 26 24922532
2021 Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans. The EMBO journal 21 33978233
2015 Evidence from enzymatic and meta-analyses does not support a direct association between USP26 gene variants and male infertility. Andrology 20 25755145
2010 Association between ubiquitin-specific protease USP26 polymorphism and male infertility in Chinese men. Clinica chimica acta; international journal of clinical chemistry 19 21147082
2008 Sequence analysis of the X-linked USP26 gene in severe male factor infertility patients and fertile controls. Fertility and sterility 19 18377898
2019 Ubiquitin-specific protease 26 (USP26) is not essential for mouse gametogenesis and fertility. Chromosoma 18 30887115
2016 The testis-specific USP26 is a deubiquitinating enzyme of the ubiquitin ligase Mdm2. Biochemical and biophysical research communications 17 27810359
2016 Single nucleotide polymorphisms of USP26 in azoospermic men. Systems biology in reproductive medicine 16 27726449
2024 USP26 promotes colorectal cancer tumorigenesis by restraining PRKN-mediated mitophagy. Oncogene 15 38565942
2021 Novel Mutations in X-Linked, USP26-Induced Asthenoteratozoospermia and Male Infertility. Cells 15 34202084
2020 Preclinical Study Using ABT263 to Increase Enzalutamide Sensitivity to Suppress Prostate Cancer Progression Via Targeting BCL2/ROS/USP26 Axis Through Altering ARv7 Protein Degradation. Cancers 15 32235588
2009 The expression of Usp26 gene in mouse testis and brain. Asian journal of andrology 15 19503076
2024 USP26 Combats Age-Related Declines in Self-Renewal and Multipotent Differentiation of BMSC by Maintaining Mitochondrial Homeostasis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 14 39377219
2020 Novel mutation in USP26 associated with azoospermia in a Sertoli cell-only syndrome patient. Molecular genetics & genomic medicine 11 32410375
2017 The impacts of nineteen mutations on the enzymatic activity of USP26. Gene 11 29111204
2020 Targeting deubiquitinating enzyme USP26 by microRNA-203 regulates Snail1's pro-metastatic functions in esophageal cancer. Cancer cell international 10 32760222
2020 USP26 deubiquitinates androgen receptor (AR) in the maintenance of sperm maturation and spermatogenesis through the androgen receptor signaling pathway. Advances in clinical and experimental medicine : official organ Wroclaw Medical University 10 33064378
2024 USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling. Nature communications 9 39251623
2024 Acetylation-dependent deubiquitinase USP26 stabilizes BAG3 to promote breast cancer progression. Cancer letters 8 38880224
2020 RAC1B Induces SMAD7 via USP26 to Suppress TGFβ1-Dependent Cell Migration in Mesenchymal-Subtype Carcinoma Cells. Cancers 8 32545415
2022 An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations. Science signaling 7 35857630
2023 Machine learning-based classification of deubiquitinase USP26 and its cell proliferation inhibition through stabilizing KLF6 in cervical cancer. Computers in biology and medicine 6 38064851
2022 The association between mutations in ubiquitin-specific protease 26 (USP26) and male infertility: a systematic review and meta-analysis. Asian journal of andrology 5 35074940
2012 [Polymorphism of Usp26 correlates with idiopathic male infertility]. Zhonghua nan ke xue = National journal of andrology 5 22568204
2021 USP26: a genetic risk factor for sperm X-Y aneuploidy. The EMBO journal 4 34031897
2010 [Mutation of the USP26 gene in spermatogenesis dysfunction]. Zhonghua nan ke xue = National journal of andrology 4 20180409
2025 Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 1 41417635
2025 A novel candidate missense variant in the catalytic domain of USP26 associated with asthenoteratozoospermia. Gene 1 41423141
2024 USP26 suppresses type I interferon signaling by targeting TRAF3 for deubiquitination. PloS one 1 39058724
2026 Osteoblastic USP26 regulates B lymphopoiesis by endogenous tryptophan metabolites. Journal of advanced research 0 41687771
2025 USP26 Promotes Cell Proliferation of Gastric Cancer by Stabilizing c-Myc. DNA and cell biology 0 41125405