UBR7
Putative E3 ubiquitin-protein ligase UBR7 · UniProt Q8N806
- Length
- 425 aa
- Mass
- 48.0 kDa
- Annotated
- 2026-06-14
17 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 17 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2019 | TurboID-based proximity labeling reveals that UBR7 is a regulator of N NLR immune receptor-mediated immunity. | Nature communications | 212 | 31324801 |
| 2020 | Manumycin polyketides act as molecular glues between UBR7 and P53. | Nature chemical biology | 102 | 32572277 |
| 2022 | UBR7 inhibits HCC tumorigenesis by targeting Keap1/Nrf2/Bach1/HK2 and glycolysis. | Journal of experimental & clinical cancer research : CR | 72 | 36419136 |
| 2019 | Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor. | Nature communications | 49 | 30923315 |
| 2021 | UBR7 acts as a histone chaperone for post-nucleosomal histone H3. | The EMBO journal | 24 | 34786730 |
| 2014 | Identification and characterization of RING-finger ubiquitin ligase UBR7 in mammalian spermatozoa. | Cell and tissue research | 22 | 24664117 |
| 2020 | UBR7 functions with UBR5 in the Notch signaling pathway and is involved in a neurodevelopmental syndrome with epilepsy, ptosis, and hypothyroidism. | American journal of human genetics | 19 | 33340455 |
| 2021 | NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia. | Science advances | 18 | 33571115 |
| 2021 | Molecular characterization of substrate-induced ubiquitin transfer by UBR7-PHD finger, a newly identified histone H2BK120 ubiquitin ligase. | The FEBS journal | 16 | 34739193 |
| 2024 | The interaction between UBR7 and PRMT5 drives PDAC resistance to gemcitabine by regulating glycolysis and immune microenvironment. | Cell death & disease | 13 | 39424627 |
| 2024 | UBR7 in concert with EZH2 inhibits the TGF-β signaling leading to extracellular matrix remodeling. | Cell reports | 11 | 38923455 |
| 2024 | MiR-10b-5p Regulates Neuronal Autophagy and Apoptosis Induced by Spinal Cord Injury Through UBR7. | Neuroscience | 5 | 38382692 |
| 2023 | The effects of the E3 ubiquitin-protein ligase UBR7 of Frankliniella occidentalis on the ability of insects to acquire and transmit TSWV. | PeerJ | 5 | 37187513 |
| 2024 | UBR7 E3 Ligase Suppresses Interferon-β Mediated Immune Signaling by Targeting Sp110 in Hepatitis B Virus-Induced Hepatocellular Carcinoma. | ACS infectious diseases | 4 | 38938101 |
| 2026 | Silencing the ubiquitin-protein ligases gene (E3-UBR7) alters acquisition, replication, and transmission of groundnut bud necrosis virus by Thrips palmi. | Virology | 0 | 41558443 |
| 2023 | Eighth case of Li-Campeau syndrome in a Turkish patient caused by a novel pathogenic variant in UBR7 and expanding the phenotype. | American journal of medical genetics. Part A | 0 | 36757286 |
| 2023 | Establishment of a novel human induced pluripotent stem cell line (SIPDi001-A) with compound heterozygous mutations in the UBR7 gene from a Li-Campeau syndrome patient. | Stem cell research | 0 | 37478672 |
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