Affinage

UBN1

Ubinuclein-1 · UniProt Q9NPG3

Length
1134 aa
Mass
121.5 kDa
Annotated
2026-06-10
33 papers in source corpus 19 papers cited in narrative 19 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

UBN1 (ubinuclein-1) is a core subunit of the HIRA/UBN1/CABIN1/ASF1a (HUCA) histone chaperone complex that drives replication-independent deposition of the histone variant H3.3 into chromatin (PMID:19029251, PMID:21807893). Within the complex, UBN1 is anchored to HIRA through its N-terminal Hpc2-related domain (NHRD, residues 41–77), which forms a tight 1:1 nanomolar complex with the HIRA WD-repeat domain and is required for HUCA stability and chromatin organization, while the previously assigned HRD is dispensable for this contact (PMID:22401310). UBN1 confers the complex's substrate specificity: its HRD selectively binds H3.3/H4 over H3.1/H4 by reading out the H3.3-specific residues Ala87 and Gly90, while its middle domain mediates dimerization and a basic DNA-binding region engages DNA through conserved lysines, together enabling formation of (H3.3/H4)2 heterotetramers prior to deposition (PMID:31040182, PMID:30285846, PMID:39059488). Genome-wide, UBN1 colocalizes with HIRA, ASF1a and H3.3 at active promoters and enhancers, and is specifically required for the de novo H3.3 deposition pathway during transcription, distinct from the ASF1-dependent recycling of old H3.3 that proceeds independently of UBN1 (PMID:23602572, PMID:32895554). UBN1 function supports diverse chromatin-dependent processes including senescence-associated heterochromatin foci formation downstream of OGT-mediated O-GlcNAcylation of HIRA-S231 (PMID:19029251, PMID:27217568), H3.3 deposition at telomeres in ALT cancer cells (PMID:39509271), proper transcriptional and epigenetic programming in oocytes and early embryos (PMID:35112132), and Xist-dependent establishment of H3K27 trimethylation during X chromosome inactivation (PMID:40455860). UBN1 was originally identified as a nuclear protein competing with EBV EB1 and c-Jun for AP1 sites and sequestered to tight junctions in differentiated epithelial cells, where it modulates the EBV productive cycle (PMID:10725330, PMID:21084479).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2000 Medium

    Established UBN1 as a nuclear protein that competes with viral and cellular bZIP transcription factors for AP1 DNA sites, defining its earliest functional context before its chromatin role was known.

    Evidence Yeast two-hybrid, Co-IP and tagged overexpression in keratinocytes mapping EB1/c-Jun interaction and nuclear localization domains

    PMID:10725330

    Open questions at the time
    • No connection yet to histone chaperone activity
    • Functional relevance of AP1 competition to gene regulation not resolved
  2. 2008 High

    Identified UBN1 as the human ortholog of yeast Hpc2p and a direct HIRA partner, placing it within the HIRA histone chaperone machinery and linking it to senescence-associated heterochromatin.

    Evidence Ortholog identification, pulldown/Co-IP mapping the HRD–HIRA WD-repeat interaction, ChIP, and RNAi with SAHF readout

    PMID:19029251

    Open questions at the time
    • Stoichiometry and full subunit composition of the complex unresolved
    • Direct histone-binding activity of UBN1 not yet demonstrated
  3. 2011 High

    Defined the quaternary HUCA complex (HIRA/UBN1/CABIN1/ASF1a) and showed it preferentially deposits H3.3 in a replication-independent manner, establishing the molecular machine UBN1 belongs to.

    Evidence Endogenous and ectopic Co-IP plus reconstitution from recombinant proteins with mutational analysis

    PMID:21807893

    Open questions at the time
    • Which subunit confers H3.3 specificity not yet assigned
    • Mechanism of histone handoff and deposition not defined
  4. 2012 High

    Mapped the precise HIRA-anchoring determinant of UBN1 to the NHRD (residues 41–77), correcting the earlier HRD assignment and quantifying the interaction as a tight 1:1 complex essential for HUCA integrity.

    Evidence Analytical ultracentrifugation, in vitro binding, mutagenesis and in vivo functional complementation in primary human cells

    PMID:22401310

    Open questions at the time
    • Structural basis of the NHRD–HIRA interface not solved
    • Role of the HRD reassigned but not yet functionally explained
  5. 2012 Medium

    Described a non-chromatin scaffold role for UBN1 at cell–cell contacts via interaction with ZO-1 and other junctional proteins, broadening its functional repertoire.

    Evidence Fluorescent protein-complementation, pulldown, Co-IP, confocal microscopy and mass spectrometry

    PMID:22245583

    Open questions at the time
    • Functional consequence of junctional localization not established
    • Relationship to nuclear chromatin function unclear
  6. 2013 High

    Localized UBN1/HIRA/ASF1a/H3.3 genome-wide to active promoters and enhancers, connecting the complex to active chromatin and gene regulation.

    Evidence ChIP-seq with HIRA-depletion functional validation and reciprocal Co-IP with transcription factors and remodelers

    PMID:23602572

    Open questions at the time
    • Causal contribution of UBN1 alone (versus HIRA) to deposition at these sites not separated
    • Mechanism of targeting to specific loci undefined
  7. 2016 High

    Linked the complex to nutrient/metabolic signaling by showing OGT interacts with UBN1 and O-GlcNAcylates HIRA-S231 to promote H3.3 assembly and senescence.

    Evidence Co-IP, O-GlcNAcylation assay, HIRA S231A mutagenesis, in vitro nucleosome assembly, and RNAi senescence readout

    PMID:27217568

    Open questions at the time
    • Whether UBN1 is itself O-GlcNAcylated not addressed
    • Single-lab; in vivo physiological relevance of the modification limited
  8. 2018 High

    Resolved how UBN1 reads H3.3 specificity, dimerizes and binds DNA, assigning the molecular activities that drive (H3.3/H4)2 tetramer formation.

    Evidence In vitro binding assays with H3.3 Ala87/Gly90 and UBN1 domain/lysine mutagenesis, plus ChIP-seq and mES differentiation assays (FID/AAA mutants)

    PMID:30285846 PMID:31040182

    Open questions at the time
    • High-resolution structure of UBN1 bound to H3.3/H4 not solved
    • Coordination of DNA binding and histone binding in vivo not directly visualized
  9. 2018 High

    Established that HIRA homotrimerization organizes the complex and is required for new H3.3 deposition and DNA damage recruitment, defining the architectural scaffold around UBN1.

    Evidence X-ray crystallography, biochemical reconstitution, trimerization-interface mutagenesis and functional rescue in HIRA KO cells

    PMID:30082790

    Open questions at the time
    • Stoichiometry of UBN1 within the trimeric assembly not fully resolved
    • Direct role of UBN1 in DNA-damage-site recruitment not isolated
  10. 2020 High

    Genetically separated the de novo and recycling H3.3 pathways, showing UBN1 is specifically required for transcription-coupled de novo deposition but dispensable for ASF1-dependent recycling.

    Evidence SNAP-tag pulse-chase distinguishing new and old histones with HIRA/UBN1 mutant analysis in human cells

    PMID:32895554

    Open questions at the time
    • How UBN1 selects de novo over recycling substrate not mechanistically defined
    • Locus-specific consequences of losing only the de novo pathway not mapped
  11. 2020 Medium

    Demonstrated conservation of UBN1 function in vivo, with C. elegans ortholog loss phenocopying hira-1 mutants including mitochondrial stress and maternal rescuability.

    Evidence Genetic loss-of-function and maternal rescue in C. elegans (PQN-80)

    PMID:32470364

    Open questions at the time
    • Molecular basis of mitochondrial stress phenotype unresolved
    • Direct link to H3.3 deposition in worm not established
  12. 2022 Medium

    Showed UBN1 is required in mouse oocytes for proper transcriptional and epigenetic programming, with loss causing embryonic failure and altered histone marks and chromatin accessibility.

    Evidence Genetic knockout with transcriptome, nascent RNA, histone-mark ChIP and ATAC-seq

    PMID:35112132

    Open questions at the time
    • Whether phenotypes are direct H3.3 deposition defects or indirect not separated
    • Specific developmental genes driving lethality not pinpointed
  13. 2024 Medium

    Extended UBN1-dependent H3.3 deposition to telomere protection in ALT cancer cells, preventing R-loop accumulation and transcription-replication conflicts.

    Evidence ATAC-seq, CUT&RUN, HIRA/UBN1/UBN2 depletion and R-loop detection in ATRX-DAXX-deficient cells

    PMID:39509271

    Open questions at the time
    • Specific contribution of UBN1 versus UBN2 at telomeres not separated
    • Therapeutic relevance not tested
  14. 2024 Medium

    Proposed a stepwise biophysical mechanism in which ASF1a delivers H3.3/H4, tetramerization couples two HIRA/UBN1 complexes, and DNA affinity drives ASF1a release and deposition.

    Evidence Biochemical reconstitution and biophysical binding assays

    PMID:39059488

    Open questions at the time
    • No mutagenesis or structural validation of the proposed intermediates
    • Single-lab in vitro model not confirmed in cells
  15. 2025 High

    Defined a specific developmental requirement for UBN1 in X chromosome inactivation, where it is needed for Xist-dependent H3K27me3 establishment but not H3K27 deacetylation, with redundancy revealed by Ubn1/Ubn2 double-mutant lethality.

    Evidence Single and double knockout mice plus ChIP for H3K27me3/ac in ES cells during Xist induction

    PMID:40455860

    Open questions at the time
    • Mechanistic link between H3.3 deposition and PRC2-mediated H3K27me3 not defined
    • Extent of UBN1/UBN2 redundancy across other tissues unclear
  16. 2025 Medium

    Identified Sp100A as required for recruiting the HIRA/UBN1/ASF1a complex to PML nuclear bodies, implicating a SUMO-dependent localization mechanism.

    Evidence CRISPR Sp100 knockout, immunofluorescence localization, isoform rescue and interferon stimulation (preprint)

    PMID:40568077

    Open questions at the time
    • Preprint not yet peer-reviewed
    • Functional consequence of PML-NB localization for H3.3 deposition not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • How UBN1 mechanistically couples H3.3 deposition to downstream chromatin states (e.g., PRC2-dependent H3K27me3 during XCI, telomere protection) and how it is targeted to distinct genomic locations remain unresolved.
  • No high-resolution structure of UBN1 within the assembled complex on histones/DNA
  • Locus-targeting specificity determinants of UBN1 undefined
  • Causal link from H3.3 deposition to specific histone-mark outcomes not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0042393 histone binding 3 GO:0060090 molecular adaptor activity 2 GO:0003677 DNA binding 1
Localization
GO:0000228 nuclear chromosome 3 GO:0005634 nucleus 2 GO:0005886 plasma membrane 2
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-4839726 Chromatin organization 3 R-HSA-74160 Gene expression (Transcription) 2
Partners
AIDASF1ACABIN1EB1HIRAOGTSP100AZO-1
Complex memberships
HUCA (HIRA/UBN1/CABIN1/ASF1a) histone chaperone complex

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 UBN1 (ubinuclein) is a nuclear protein that interacts with the basic domains of EBV transcription factor EB1 and cellular c-Jun, competing with their binding to the AP1 consensus site. The NH2 terminus is essential for nuclear localization, while the central domain mediates interaction with EB1. Yeast two-hybrid, co-immunoprecipitation, overexpression of tagged constructs in keratinocytes The Journal of cell biology Medium 10725330
2008 UBN1 is the human ortholog of yeast Hpc2p. Its Hpc2-related domain (HRD) directly interacts with the N-terminal WD repeats of HIRA. UBN1 binds to proliferation-promoting genes repressed during senescence, associates with H3K9 histone methyltransferase activity, and is indispensable for formation of senescence-associated heterochromatin foci (SAHF). Bioinformatic ortholog identification, pulldown assays, co-immunoprecipitation, ChIP, RNAi knockdown with SAHF phenotype readout Molecular and cellular biology High 19029251
2011 UBN1 is a core subunit of the quaternary HIRA/UBN1/CABIN1/ASF1a (HUCA) complex. HIRA acts as a scaffold to bring together UBN1, ASF1a, and CABIN1. The intact HUCA complex preferentially deposits histone variant H3.3 into chromatin in a DNA replication-independent manner and contributes to heterochromatinization in senescent cells. Co-immunoprecipitation at ectopic and endogenous levels, reconstitution of quaternary complex from recombinant proteins, mutational analysis Molecular and cellular biology High 21807893
2012 A region within residues 41–77 of UBN1, termed the NHRD (N-terminal Hpc2-related domain), is essential for interaction with the HIRA WD repeat domain, forming a tight 1:1 complex with nanomolar affinity. The previously identified HRD (residues 120–175) is dispensable for this interaction. Key residues in the NHRD are required for HUCA complex stability in vitro and in vivo and for chromatin organization in primary human cells. Biochemical/mutational analysis, analytical ultracentrifugation, in vitro binding assays, in vivo functional complementation Biochemistry High 22401310
2012 UBN1 interacts with tight junction protein ZO-1 via UBN1's N-terminal region (residues 39–223) and ZO-1's PDZ2 domain. UBN1 also interacts with cingulin, LYRIC, and RACK-1, suggesting a scaffold function influencing protein subcellular localization at cell–cell contacts. Fluorescent protein-complementation assay (PCA), in vitro pull-down, co-immunoprecipitation, confocal microscopy, mass spectrometry Experimental cell research Medium 22245583
2013 UBN1 colocalizes with HIRA, ASF1a, and histone H3.3 predominantly at active promoters and active/poised enhancers genome-wide. HIRA is required for deposition of H3.3 at these binding sites. Physical interactions between the HIRA complex (including UBN1) and transcription factors, a chromatin insulator, and an ATP-dependent chromatin-remodeling complex were identified. ChIP-seq, gene expression analysis, co-immunoprecipitation Cell reports High 23602572
2016 OGT (O-GlcNAc transferase) interacts with UBN1 and O-GlcNAcylates HIRA at S231, promoting formation of the HIRA–H3.3 complex and H3.3 nucleosome assembly. Depletion of OGT or expression of HIRA S231A mutant compromises H3.3 nucleosome assembly and delays premature cellular senescence. Co-immunoprecipitation, O-GlcNAcylation assay, site-directed mutagenesis (HIRA S231A), nucleosome assembly assay, RNAi knockdown with senescence phenotype readout Proceedings of the National Academy of Sciences of the United States of America High 27217568
2018 The UBN1 HRD specifically binds to H3.3/H4 over H3.1/H4, providing selectivity for the histone variant. The UBN1 middle domain has dimer formation activity and binds H3/H4 without discriminating between H3.1 and H3.3. A DNA-binding domain located between the HRD and middle domain binds DNA through electrostatic contacts involving conserved lysine residues. These activities suggest UBN1 associates with DNA and dimerizes to mediate (H3.3/H4)2 heterotetramer formation prior to chromatin deposition. In vitro binding assays, mutagenesis of conserved lysine residues, biochemical characterization of domains The Journal of biological chemistry High 31040182
2018 Ala87 and Gly90 residues of H3.3 are required and sufficient for specific recognition and direct binding by UBN1. The HIRA subunit enhances UBN1 binding affinity toward H3.3, whereas CABIN1 does not. UBN1 (and UBN2) FID/AAA histone chaperone activity mutations cause defects in H3.3 deposition at promoters of developmental genes and impair neural differentiation of mouse ES cells. In vitro binding assays, site-directed mutagenesis of H3.3 residues, ChIP-seq, FID/AAA mutant functional analysis in mES cell differentiation BMC biology High 30285846
2018 HIRA forms a stable homotrimer that binds two subunits of CABIN1 in vitro. A HIRA mutant defective in homotrimer formation interacts less efficiently with CABIN1, is not enriched at DNA damage sites upon UV irradiation, and cannot rescue new H3.3 deposition in HIRA knockout cells. UBN1 is a subunit of this trimeric complex. Biochemical analysis, X-ray crystallography, mutagenesis of HIRA trimerization interface, functional rescue assay in HIRA KO cells, UV damage localization Nature communications High 30082790
2010 UBN1 overexpression represses the EBV productive cycle in epithelial cells, whereas UBN1 knockdown increases virus production. UBN1 blocks EB1-DNA interaction as shown by ChIP. In non-dividing differentiated epithelial cells, UBN1 is relocalized/sequestered to tight junctions, allowing EB1 to activate the productive cycle in the nucleus. Overexpression, shRNA knockdown, ChIP, confocal microscopy for subcellular localization Journal of virology Medium 21084479
2020 De novo H3.3 deposition during transcription is totally dependent on HIRA trimerization and on UBN1, while ASF1 interaction with HIRA can be bypassed for this pathway. In contrast, recycling of old H3.3 requires HIRA but proceeds independently of UBN1 or HIRA trimerization and shows absolute dependency on ASF1-HIRA interaction. Thus UBN1 is specifically required for the de novo deposition pathway but not the recycling pathway. SNAP-tag pulse-chase to distinguish new and old histones, HIRA/UBN1 mutant analysis, fluorescence imaging in human cells Nature structural & molecular biology High 32895554
2020 In C. elegans, PQN-80 (the UBN1 ortholog) loss of function causes late-onset pleiotropic defects similar to hira-1 mutants including mitochondrial stress, and these defects can be maternally rescued by maternally derived complex components. Genetic loss-of-function screen, phenotypic analysis, maternal rescue experiments Current biology : CB Medium 32470364
2022 Loss of Ubn1 function in mouse oocytes (as part of the Hira/Cabin1/Ubn1 complex) causes early embryogenesis failure. Transcriptome analyses show aberrant transcriptional silencing in mutant oocytes, with reduced H3K4me3 and H3K9me3 marks and impaired chromatin accessibility. Genetic knockout, transcriptome analysis, nascent RNA analysis, histone mark ChIP, chromatin accessibility assay (ATAC) Development (Cambridge, England) Medium 35112132
2023 UBN1 directly interacts with AID (activation-induced cytidine deaminase) in B cells. Co-immunoprecipitation, pull-down, co-localization by double immunofluorescence, and proximity ligation assay all confirm this interaction. Co-immunoprecipitation, pull-down, double immunofluorescence, proximity ligation assay, molecular docking Scientific reports Medium 37949972
2024 The HIRA-UBN1/UBN2 complex deposits new H3.3 at telomeres to prevent accumulation of nucleosome-free ssDNA, TERRA R-loop buildup, and transcription-replication conflicts in ATRX-DAXX-deficient ALT cancer cells. HIRA-mediated H3.3 incorporation links productive ALT to phosphorylation of H3.3 serine 31 by Chk1. ATAC-seq, CUT&RUN, HIRA/UBN1/UBN2 depletion with defined molecular phenotypes, R-loop detection Cell reports Medium 39509271
2024 ASF1a delivers H3.3/H4 dimers to the HIRA complex; H3.3/H4 tetramerization drives association of two HIRA/UBN1 complexes; and affinity of histones for DNA drives release of ASF1a and subsequent histone deposition. Biochemical and biophysical data support this stepwise mechanism for HIRA-complex-mediated H3.3/H4 deposition. Biochemical reconstitution, biophysical binding assays The Journal of biological chemistry Medium 39059488
2025 Ubn1 single mutant mice are viable and fertile, while combined Ubn1/Ubn2 double mutants show complete embryonic lethality. Mechanistically, Ubn1 mutation in mouse ES cells impairs initiation of X chromosome inactivation: Xist-mediated establishment of H3K27me3 over X-linked genes is impaired, while Xist-dependent deacetylation of H3K27 remains largely unaffected. Genetic knockout (single and double mutant), mouse phenotypic analysis, ChIP for H3K27me3/ac in ES cells during Xist induction PLoS genetics High 40455860
2025 Sp100A isoform is required for localization of the HIRA complex (including UBN1 and ASF1a) to PML nuclear bodies in human keratinocytes. In Sp100 knockout cells, HIRA/UBN1/ASF1a fail to localize to PML-NBs even after interferon stimulation; exogenous Sp100A rescues this, with the SUMO interacting motif (SIM) playing an important role. CRISPR-Cas9 Sp100 knockout, immunofluorescence localization, exogenous isoform expression rescue, interferon stimulation bioRxivpreprint Medium 40568077

Source papers

Stage 0 corpus · 33 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT. American journal of human genetics 141 15830322
2013 Placing the HIRA histone chaperone complex in the chromatin landscape. Cell reports 119 23602572
2008 Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Molecular and cellular biology 104 19029251
2011 Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. Molecular and cellular biology 90 21807893
2015 Identification of embryonic lethal genes in humans by autozygosity mapping and exome sequencing in consanguineous families. Genome biology 89 26036949
2018 Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis. PLoS pathogens 83 30235352
2020 Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription. Nature structural & molecular biology 57 32895554
2018 Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit. Nature communications 50 30082790
2018 UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells. BMC biology 40 30285846
2016 A Molecular Prospective for HIRA Complex Assembly and H3.3-Specific Histone Chaperone Function. Journal of molecular biology 38 27871933
2000 Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors. The Journal of cell biology 36 10725330
2016 O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence. Proceedings of the National Academy of Sciences of the United States of America 35 27217568
2012 Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex. Biochemistry 32 22401310
2016 HIRA Is Required for Heart Development and Directly Regulates Tnni2 and Tnnt3. PloS one 27 27518902
2010 Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4. PloS one 25 20976105
2015 Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. Molecular endocrinology (Baltimore, Md.) 24 26305679
2019 The HIRA histone chaperone complex subunit UBN1 harbors H3/H4- and DNA-binding activity. The Journal of biological chemistry 21 31040182
2019 Introducing gene deletions by mouse zygote electroporation of Cas12a/Cpf1. Transgenic research 19 31482512
2024 HIRA protects telomeres against R-loop-induced instability in ALT cancer cells. Cell reports 16 39509271
2022 The H3.3 chaperone Hira complex orchestrates oocyte developmental competence. Development (Cambridge, England) 16 35112132
2012 Identification of new interacting partners of the shuttling protein ubinuclein (Ubn-1). Experimental cell research 16 22245583
2020 H3.3 Nucleosome Assembly Mutants Display a Late-Onset Maternal Effect. Current biology : CB 8 32470364
2020 SRSF1-3, a splicing and somatic hypermutation regulator, controls transcription of IgV genes via chromatin regulators SATB2, UBN1 and histone variant H3.3. Molecular immunology 7 31986311
2010 The nuclear and adherent junction complex component protein ubinuclein negatively regulates the productive cycle of Epstein-Barr virus in epithelial cells. Journal of virology 7 21084479
2022 Histone chaperone HIRA complex regulates retrotransposons in embryonic stem cells. Stem cell research & therapy 6 35365225
2019 Genome-Wide Analysis of Allele-Specific Expression Patterns in Seventeen Tissues of Korean Cattle (Hanwoo). Animals : an open access journal from MDPI 5 31561539
2023 Using multi-tissue transcriptome-wide association study to identify candidate susceptibility genes for respiratory infectious diseases. Frontiers in genetics 3 37020999
2023 Activation-induced cytidine deaminase an antibody diversification enzyme interacts with chromatin modifier UBN1 in B-cells. Scientific reports 3 37949972
2025 Prioritization of predisposition genes for familial non-medullary thyroid cancer by whole-genome sequencing. European journal of endocrinology 2 40177881
2025 Sp100A isoform promotes HIRA histone chaperone localization to PML nuclear bodies. bioRxiv : the preprint server for biology 2 40568077
2024 HIRA complex deposition of histone H3.3 is driven by histone tetramerization and histone-DNA binding. The Journal of biological chemistry 1 39059488
2025 Ubinuclein 2 is essential for mouse development and functions in X chromosome inactivation. PLoS genetics 0 40455860
2025 A practical framework for predicting splicing single nucleotide variants in exome sequencing. NAR genomics and bioinformatics 0 41424762

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