Affinage

UBE2V1

Ubiquitin-conjugating enzyme E2 variant 1 · UniProt Q13404

Length
147 aa
Mass
16.5 kDa
Annotated
2026-04-28
31 papers in source corpus 21 papers cited in narrative 21 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

UBE2V1 (Uev1A) is a catalytically inactive ubiquitin E2 variant that heterodimerizes with Ubc13 (UBE2N) to direct Lys63-linked polyubiquitin chain assembly, functioning as a critical cofactor in NF-κB activation, SAPK/JNK signaling, AMPA receptor endosomal trafficking, and protein aggregate homeostasis (PMID:16129784, PMID:12591926, PMID:21179194, PMID:32081062). UBE2V1 lacks the active-site cysteine required for ubiquitin conjugation and instead positions the acceptor ubiquitin Lys63 near the Ubc13 catalytic center through a dedicated binding surface, with its unique N-terminal extension distinguishing it from the paralog Mms2 and being required for K63-chain elongation and NF-κB output (PMID:9418904, PMID:16893187, PMID:17709375, PMID:32659264). Beyond K63-linked ubiquitination, UBE2V1 participates in Ubc13-independent K48-linked degradation of Smad1 via Smurf1, collaborates with UBE2S in K11/K48-linked ubiquitination of VHL, and cooperates with the APC/C to degrade Cyclin A, revealing versatile roles in proteasomal substrate targeting (PMID:28771228, PMID:41446875, PMID:41879050). In cancer contexts, UBE2V1 promotes metastasis through NF-κB-dependent upregulation of MMP1 and CXCL1, activates AKT signaling, and epigenetically suppresses autophagy genes by promoting Sirt1 degradation (PMID:25022892, PMID:29662619, PMID:31827405, PMID:30016968).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1998 High

    Establishing that UBE2V1 is a catalytically inactive E2 variant resolved why it cannot conjugate ubiquitin alone yet influences cell cycle progression and differentiation, setting the stage for understanding its obligate cofactor role.

    Evidence In vitro ubiquitin conjugation assays demonstrated absence of thioester formation; overexpression in HT-29-M6 cells caused G2-M accumulation and Cdk1 inhibition; yeast complementation showed conserved DNA damage tolerance function

    PMID:9418904 PMID:9580084

    Open questions at the time
    • No binding partner identified at this stage
    • Mechanism of cell cycle effects unclear without an E2 partner
  2. 2003 High

    Demonstrating that UBE2V1 forms a functional heterodimer with Ubc13 for K63-linked ubiquitination of TRAF2 connected the inactive E2 variant to TNF-induced SAPK/JNK signaling, establishing the obligate E2 partnership.

    Evidence Dominant-negative Ubc13, RNAi, immunoprecipitation, and kinase assays in TNFα-stimulated cells

    PMID:12591926

    Open questions at the time
    • Structural basis of the Uev1A-Ubc13 interaction unknown
    • Whether Uev1A is required for all Ubc13 functions or specific subsets unclear
  3. 2005 High

    Functional separation of Uev1A from Mms2 showed that Uev1A-Ubc13 directs NF-κB activation while Mms2-Ubc13 handles DNA damage repair, resolving how two highly similar cofactors achieve pathway specificity.

    Evidence RNAi knockdown, NF-κB reporter assays, DNA damage sensitivity assays, in vitro chain assembly comparing Uev1A vs. Mms2

    PMID:16129784

    Open questions at the time
    • Molecular determinant of pathway selectivity (N-terminal extension) not yet identified
    • In vivo confirmation of paralog specialization lacking
  4. 2006 High

    NMR structure of Uev1A and structural modeling of the Ub-Uev1A-Ubc13-Ub tetramer revealed the hydrogen-bond network positioning Lys63 for attack, providing the first atomic-level explanation of K63-linkage specificity.

    Evidence NMR spectroscopy with restrained molecular dynamics simulations

    PMID:16893187

    Open questions at the time
    • No crystal structure of the full catalytic complex with donor ubiquitin thioester
    • Dynamics of chain elongation versus initiation not structurally resolved
  5. 2007 High

    Reconstitution of TRAF6 ubiquitination dissected two mechanistically distinct steps—UEV1A-independent substrate modification and UEV1A-dependent K63-chain elongation—clarifying Uev1A's specific role as a chain-building cofactor rather than a substrate-targeting factor.

    Evidence In vitro ubiquitination reconstitution with TRAF6, mutant ubiquitin panel

    PMID:17709375

    Open questions at the time
    • Identity of the E2 responsible for the initial substrate-attached ubiquitin unknown
    • Whether this two-step model generalizes to all Uev1A substrates untested
  6. 2010 High

    A forward genetic screen in C. elegans revealed a conserved role for UEV-1/Ubc13 in endosomal trafficking of AMPA receptors, extending Uev1A function beyond signaling and degradation to membrane receptor recycling.

    Evidence Genetic screen, in vivo fluorescent imaging of GLR-1 in neurons, epistasis with ubc-13 mutants, co-localization with RAB-10 endosomes

    PMID:21179194

    Open questions at the time
    • Direct ubiquitination substrate in the trafficking pathway not identified
    • Whether mammalian UBE2V1 performs the same neuronal trafficking role untested
  7. 2014 High

    Identification of MMP1 as the critical NF-κB target downstream of Uev1A-Ubc13 in breast cancer metastasis established a complete signaling axis from E2 cofactor to invasive effector.

    Evidence Overexpression/knockdown, invasion assays, xenograft mouse model, MMP1 rescue experiments

    PMID:25022892

    Open questions at the time
    • Whether Uev1A-driven NF-κB activation in metastasis is TRAF6-dependent or uses other E3s unclear
    • Contribution of non-NF-κB pathways (AKT) to metastasis not dissected in this study
  8. 2017 Medium

    Discovery that Uev1A partners with Smurf1 for K48-linked ubiquitination of Smad1 independently of Ubc13 overturned the assumption that Uev1A acts exclusively through K63-linked chains and Ubc13, revealing an unexpected Ubc13-independent degradative role.

    Evidence Co-immunoprecipitation, ubiquitination assays specifying K48 linkage, Smad1 rescue in osteosarcoma differentiation

    PMID:28771228

    Open questions at the time
    • Structural basis for Ubc13-independent function unknown
    • Whether Uev1A contributes catalytic activity or acts as an adaptor in this context unresolved
    • Independent replication needed
  9. 2018 Medium

    Identification of Sirt1 as a K63-ubiquitination target whose degradation epigenetically suppresses autophagy genes linked Uev1A to chromatin regulation and colorectal cancer metastasis, expanding its oncogenic repertoire beyond NF-κB.

    Evidence Quantitative mass spectrometry, Co-IP, ubiquitination assay, in vivo rescue in xenograft models

    PMID:30016968

    Open questions at the time
    • Mechanism by which K63-linked ubiquitination leads to proteasomal degradation of Sirt1 unclear
    • Direct E3 ligase for Sirt1 in this context not identified
  10. 2020 High

    Cardiac-specific Ube2v1 knockout demonstrated that K63-ubiquitination by Uev1A-Ubc13 impairs proteasome function and promotes protein aggregate pathology, establishing an in vivo physiological role in proteostasis beyond cancer signaling.

    Evidence AAV9-CRISPR cardiac knockout, UPS reporter assay, K63-ubiquitin Western blot, echocardiography in CryABR120G mice

    PMID:32081062

    Open questions at the time
    • Direct proteasomal substrates affected by K63 chains not identified
    • Whether Ube2v1 loss is cardioprotective in other forms of protein aggregate cardiomyopathy unknown
  11. 2020 High

    Characterization of the Uev1A N-terminal extension as the determinant of weaker Ubc13 affinity and NF-κB-specific output resolved the long-standing question of how Uev1A and Mms2 achieve pathway selectivity despite sharing the UEV domain.

    Evidence In vitro ubiquitination, thermodynamic binding measurements, NF-κB reporter, chimeric Mms2-Uev1A N-terminus protein

    PMID:32659264

    Open questions at the time
    • How reduced affinity translates into differential pathway activation mechanistically unclear
    • Whether post-translational modifications of the N-terminus modulate function unknown
  12. 2025 Medium

    Discovery that UBE2V1 cooperates with UBE2S for K11/K48-linked ubiquitination of VHL and with APC/C for Cyclin A degradation revealed that UBE2V1 participates in mixed-linkage and non-K63 ubiquitin chain types through alternative E2/E3 partnerships, substantially broadening its enzymatic repertoire.

    Evidence Co-IP, linkage-specific ubiquitination assays, VHL K196 mutagenesis, genetic screen in Drosophila, Cyclin A degradation assays, xenograft and tumor models

    PMID:41446875 PMID:41879050

    Open questions at the time
    • Structural basis for UBE2V1-UBE2S cooperation unknown
    • Whether UBE2V1 contributes directly to APC/C catalysis or acts as a regulatory cofactor unresolved
    • Both findings from single labs; independent replication needed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How UBE2V1 selects among Ubc13, UBE2S, Smurf1, and APC/C partnerships in different cellular contexts, and the structural basis for its participation in non-K63 chain types, remain open questions.
  • No structure of UBE2V1 in complex with UBE2S or APC/C
  • Regulatory inputs (post-translational modifications, expression dynamics) controlling partner selection uncharacterized
  • Comprehensive substrate catalog across tissue types lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 7 GO:0098772 molecular function regulator activity 4
Localization
GO:0005829 cytosol 2 GO:0005634 nucleus 1 GO:0005768 endosome 1
Pathway
R-HSA-162582 Signal Transduction 7 R-HSA-392499 Metabolism of proteins 6 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 3 R-HSA-1640170 Cell Cycle 2 R-HSA-5357801 Programmed Cell Death 2 R-HSA-73894 DNA Repair 2 R-HSA-9612973 Autophagy 2
Partners
RHBDF2SIRT1SMURF1STUB1TRAF2TRAF6UBE2NUBE2S
Complex memberships
APC/CUbc13-Uev1A heterodimer

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 UBE2V1 (Uev1A) forms a heterodimer with Ubc13 and directs it toward Lys63-linked polyubiquitination for NF-κB activation, while the paralog Mms2-Ubc13 is required for DNA damage repair but not NF-κB activation; the two Uevs differentially modulate the length of K63-linked polyubiquitin chains produced by Ubc13. In vitro ubiquitination assays, cell-based NF-κB reporter assays, DNA damage sensitivity assays, RNAi knockdown, structural comparison The Journal of cell biology High 16129784
2003 The Ubc13-Uev1A E2 complex is required for TNF-induced TRAF2 K63-linked polyubiquitination and oligomerization, GCKR ubiquitination/activation, and downstream SAPK/JNK pathway activation; disruption of Ubc13 inhibits these events without affecting ASK1 activation. Dominant-negative Ubc13 expression, RNAi knockdown, immunoprecipitation, ubiquitination assays, kinase activity assays The Journal of biological chemistry High 12591926
2007 UEV1A presents Lys63 of acceptor ubiquitin to Ubc13 to direct K63-linked chain synthesis; UEV1A suppresses modification of the substrate TRAF6 itself while promoting free K63-linked ubiquitin chain synthesis, indicating a UEV1A-independent substrate modification step and UEV1A-dependent chain elongation step. In vitro ubiquitination reconstitution with TRAF6, mutant ubiquitin analysis, biochemical fractionation The Journal of biological chemistry High 17709375
2006 NMR structure of hUev1a determined; structural model of the Ub-hUev1a-hUbc13-Ub tetramer reveals a hydrogen-bond network involving hUbc13-Asp81 and Ub-Glu64 that positions Ub-Lys63 proximal to the active site for K63-linked chain synthesis; deprotonation of Ub-Lys63 does not require a general Asp/Glu base. NMR spectroscopy, restrained molecular dynamics simulations, structural modeling Biochemistry High 16893187
2006 Overexpression of UEV1A alone is sufficient to activate NF-κB and upregulate the anti-apoptotic protein Bcl-2, conferring cell survival under serum deprivation and protection against diverse apoptotic stimuli; these effects are reversed by RNAi knockdown of UEV1, identifying Uev1A as a regulatory component of the NF-κB pathway. Overexpression, RNAi knockdown, NF-κB reporter assay, Western blotting, cell survival assays Apoptosis Medium 17041755
2012 The small molecule NSC697923 inhibits UBE2V1 (Uev1A)-Ubc13 activity by impeding formation of the Ubc13-ubiquitin thioester conjugate, suppressing constitutive NF-κB activity in DLBCL cells. In vitro ubiquitination assay, thioester formation assay, NF-κB reporter assay, cell proliferation/survival assays Blood High 22791293
2008 Leucettamol A inhibits the protein-protein interaction between Ubc13 and Uev1A, requiring hydroxyl and/or amino groups for activity; this interaction surface is essential for Ubc13 E2 activity. ELISA-based protein interaction inhibition assay, structure-activity relationship with chemical derivatives Bioorganic & medicinal chemistry letters Medium 19006668
2014 Uev1A overexpression promotes breast cancer cell invasion and metastasis through NF-κB activation in a manner requiring functional Ubc13; among NF-κB target genes, MMP1 is the critical downstream effector, and MMP1 overexpression rescues the metastasis defect caused by UEV1 depletion. Overexpression/knockdown, invasion assay, xenograft mouse model, NF-κB reporter, rescue experiments with MMP1 Breast cancer research High 25022892
2017 Uev1A collaborates with the E3 ligase Smurf1 to promote K48-linked ubiquitination and proteasomal degradation of Smad1 in a Ubc13-independent manner, driving osteosarcoma differentiation and suppressing stem cell properties; Smad1 is identified as the dominant downstream effector. Co-immunoprecipitation, ubiquitination assay, Western blotting, overexpression/knockdown, rescue experiments Cell death & disease Medium 28771228
2017 The Uev1A-Ubc13 complex interacts with RHBDF2 and, upon TNFα stimulation, cooperates with the E3 CHIP to catalyze K63-linked ubiquitination of RHBDF2, enhancing TACE maturation and subsequent shedding of the TNFα receptor, thereby acting as a negative feedback regulator of NF-κB signaling. Co-immunoprecipitation, K63-ubiquitination assay, TACE maturation assay, overexpression/knockdown Cellular signalling Medium 29069608
2018 Ube2v1 promotes Ubc13-mediated K63-linked polyubiquitination and proteasomal degradation of Sirt1, reducing histone H4K16 acetylation and epigenetically suppressing autophagy gene expression, thereby promoting colorectal cancer metastasis. Quantitative mass spectrometry, Co-immunoprecipitation, ubiquitination assay, Western blotting, immunofluorescence, in vivo rescue experiments Journal of hematology & oncology Medium 30016968
2018 Uev1A-Ubc13 promotes colorectal cancer metastasis via NF-κB activation, requiring physical interaction with Ubc13; CXCL1 is identified as the critical NF-κB target gene mediating invasion, with depletion of Uev1 reducing CXCL1 and preventing metastasis in xenograft models. Overexpression/knockdown, invasion assay, xenograft mouse model, NF-κB reporter, CXCL1 rescue experiments Oncotarget Medium 29662619
2020 Ube2v1 positively regulates protein aggregate formation in cardiomyocytes via K63-linked ubiquitination; knockdown of Ube2v1 improves proteasome performance and reduces insoluble ubiquitinated proteins without affecting autophagy, and cardiac-specific Ube2v1 knockout alleviates CryABR120G-induced aggregation and improves cardiac function in vivo. Adenoviral overexpression/knockdown, AAV9-mediated CRISPR knockout, UPS reporter assay, K63-ubiquitin Western blot, cardiac function assays in mice Circulation research High 32081062
2020 The N-terminal extension unique to Uev1A (absent in Mms2) is required for poly-ubiquitin chain assembly and NF-κB activation; it weakens Uev1A-Ubc13 affinity relative to Mms2-Ubc13, and a chimeric protein bearing the Uev1A N-terminus fused to Mms2 functionally substitutes for Uev1A. In vitro ubiquitination assay, thermodynamic binding measurements, NF-κB reporter assay, chimeric protein analysis Cellular signalling High 32659264
2019 Uev1A promotes breast cancer cell survival through the AKT-FOXO1-BIM axis: Uev1A overexpression activates AKT, which suppresses FOXO1 and BIM expression, conferring chemoresistance; Uev1 depletion inhibits AKT and promotes FOXO1/BIM expression to reduce survival. Overexpression/knockdown, Western blotting of AKT pathway components, cell survival and chemosensitivity assays Cancer cell international Medium 31827405
2010 C. elegans UEV-1 (ortholog of UBE2V1) regulates trafficking of the AMPA receptor subunit GLR-1; loss of uev-1 causes GLR-1 accumulation in RAB-10-containing endosomes in neuronal cell bodies and processes; UEV-1 interacts with UBC-13, and ubc-13 mutants share the same phenotype, indicating they act together. Forward genetic screen, fluorescent protein imaging in vivo, behavioral assays, epistasis with ubc-13 mutants, endosomal marker co-localization PloS one High 21179194
1998 UBE2V1/UEV-1A proteins lack the active-site cysteine of E2 enzymes and cannot conjugate or transfer ubiquitin in vitro; constitutive UEV expression in HT-29-M6 cells inhibits differentiation, increases G2-M accumulation, and inhibits the mitotic kinase Cdk1. In vitro ubiquitin conjugation assay, cell cycle analysis, Cdk1 kinase assay, differential RNA display, exogenous expression Molecular and cellular biology High 9418904
1998 Human UEV-1A functionally complements the yeast YGL087c (uev) deletion mutant for UV and MMS sensitivity, establishing a conserved role in DNA damage tolerance. Genetic complementation of yeast null mutant, DNA damage sensitivity assay FEBS letters Medium 9580084
2020 Drosophila Uev1a (ortholog of UBE2V1) forms a stable heterodimer with Ben (Drosophila Ubc13); the F15E mutation in dUev1a abolishes this interaction, and F15Y severely reduces it; the complex is required for DNA damage tolerance (functional rescue of yeast mms2 null) and neurological signaling/mobility in flies. Yeast two-hybrid, yeast complementation, DNA damage sensitivity assay, Drosophila mutant behavioral assays Cellular signalling Medium 32702441
2025 UBE2V1 collaborates with the APC/C E3 complex to mediate proteasomal degradation of Cyclin A, thereby counteracting oncogenic Ras-induced division stress; overexpression of UBE2V1 or its Drosophila ortholog Uev1A suppresses Ras-driven overgrowth in vivo. Genome-wide genetic screen in Drosophila, overexpression/knockdown, Cyclin A degradation assay, xenograft mouse model eLife Medium 41879050
2025 UBE2V1 (in complex with UBE2S) catalyzes K11/K48-linked ubiquitination of VHL at K196, leading to its proteasomal degradation; this is triggered by UBE2V1 competing with HIF-1α for binding to the VHL β-domain, creating a positive feedback loop that stabilizes HIF-1α in hepatocellular carcinoma. Co-immunoprecipitation, ubiquitination assay specifying K11/K48 linkages, site-directed mutagenesis (VHL K196), Western blotting, in vivo tumor models, ChIP for HIF-1α binding to UBE2V1 promoter Research (Washington, D.C.) Medium 41446875

Source papers

Stage 0 corpus · 31 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A. The Journal of cell biology 150 16129784
2003 Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2). The Journal of biological chemistry 149 12591926
2012 Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. Blood 129 22791293
1998 Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. Molecular and cellular biology 117 9418904
1998 The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. Nucleic acids research 90 9705497
2018 Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy. Journal of hematology & oncology 80 30016968
2008 Leucettamol A: a new inhibitor of Ubc13-Uev1A interaction isolated from a marine sponge, Leucetta aff. microrhaphis. Bioorganic & medicinal chemistry letters 63 19006668
2007 Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme. The Journal of biological chemistry 43 17709375
2020 Ube2v1 Positively Regulates Protein Aggregation by Modulating Ubiquitin Proteasome System Performance Partially Through K63 Ubiquitination. Circulation research 40 32081062
2014 Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-кB mediated matrix metalloproteinase-1 gene regulation. Breast cancer research : BCR 40 25022892
1997 CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter. Gene 39 9305758
2006 Uev1A, a ubiquitin conjugating enzyme variant, inhibits stress-induced apoptosis through NF-kappaB activation. Apoptosis : an international journal on programmed cell death 33 17041755
1998 Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines. Oncogene 32 9771976
2016 Simulated Microgravity Promotes Cell Apoptosis Through Suppressing Uev1A/TICAM/TRAF/NF-κB-Regulated Anti-Apoptosis and p53/PCNA- and ATM/ATR-Chk1/2-Controlled DNA-Damage Response Pathways. Journal of cellular biochemistry 31 26887372
2010 UEV-1 is an ubiquitin-conjugating enzyme variant that regulates glutamate receptor trafficking in C. elegans neurons. PloS one 24 21179194
2018 Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-кB activation. Oncotarget 23 29662619
2017 Uev1A facilitates osteosarcoma differentiation by promoting Smurf1-mediated Smad1 ubiquitination and degradation. Cell death & disease 23 28771228
2017 Uev1A-Ubc13 catalyzes K63-linked ubiquitination of RHBDF2 to promote TACE maturation. Cellular signalling 19 29069608
2002 A homologue of CROC-1 in a ciliated protist (Sterkiella histriomuscorum) testifies to the ancient origin of the ubiquitin-conjugating enzyme variant family. Molecular biology and evolution 18 11752188
1998 Role of UEV-1A, a homologue of the tumor suppressor protein TSG101, in protection from DNA damage. FEBS letters 16 9580084
2019 Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway. Cancer cell international 15 31827405
2006 Structure and interactions of the ubiquitin-conjugating enzyme variant human Uev1a: implications for enzymatic synthesis of polyubiquitin chains. Biochemistry 14 16893187
2023 Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10. International journal of medical sciences 12 37786443
2019 The C-terminal extension of Arabidopsis Uev1A/B with putative prenylation site plays critical roles in protein interaction, subcellular distribution and membrane association. Plant science : an international journal of experimental plant biology 10 31928655
2021 Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway. BMC cancer 7 34503444
2021 Expression and clinical significance of UBE2V1 in cervical cancer. Biochemistry and biophysics reports 5 34466666
2020 Drosophila Uev1a is dually required for Ben-dependent DNA-damage response and fly mobility. Cellular signalling 5 32702441
2020 Uev1A amino terminus stimulates poly-ubiquitin chain assembly and is required for NF-κB activation. Cellular signalling 3 32659264
2025 UBE2V1 governs aging induced protein aggregation and developmental defects in oocytes and embryos. Communications biology 1 40394227
2026 Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells. eLife 0 41879050
2025 UBE2V1 Promotes Hepatocellular Carcinoma Progression by Forming a Positive Feedback Loop with HIF-1α. Research (Washington, D.C.) 0 41446875