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Showing PRPF6 — U5-102K is a alias.

PRPF6

Pre-mRNA-processing factor 6 · UniProt O94906

Length
941 aa
Mass
106.9 kDa
Annotated
2026-06-10
100 papers in source corpus 7 papers cited in narrative 7 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PRPF6 (hPrp6/U5-102K) is an essential pre-mRNA splicing factor that bridges the U5 and U4/U6 snRNPs to drive assembly of the [U4/U6.U5] tri-snRNP, a function conserved from the yeast ortholog PRP6 (PMID:2147224, PMID:15840814). As a component of the 20S U5 snRNP, PRPF6 directly contacts the U4/U6-61K protein to physically link the two particles and is specifically required for tri-snRNP accumulation rather than for the upstream U4/U6 di-snRNP, since loss of its function depletes tri-snRNP while leaving U4/U6 intact (PMID:8479905, PMID:15840814). PRPF6 also interacts with U5-52K (CD2BP2), which dissociates upon tri-snRNP formation, consistent with a role in the assembly transition (PMID:15840814). A dominant p.Arg729Trp missense mutation causes autosomal-dominant retinitis pigmentosa, mislocalizing PRPF6 to Cajal bodies and producing intron retention in transcripts with specific splicing signals, implicating defective tri-snRNP assembly/recycling in retinal degeneration (PMID:21549338). In cancer, PRPF6 acts through this splicing activity to favor production of growth-promoting transcript isoforms, including an oncogenic ZAK kinase isoform, such that its depletion selectively arrests proliferation of tumor cells with high tri-snRNP levels (PMID:24788092).

Mechanistic history

Synthesis pass · year-by-year structured walk · 6 steps
  1. 1990 High

    Established that the gene product is a bona fide splicing factor physically associated with snRNAs, defining its place in the spliceosome rather than a generic nuclear role.

    Evidence Anti-PRP6 immunoprecipitation of U4/U6 snRNAs and defective in vitro splicing in temperature-sensitive prp6 yeast extracts; parallel sequencing/mutagenesis identifying conserved cysteine/histidine and helix-loop-helix motifs

    PMID:2118103 PMID:2147224

    Open questions at the time
    • Did not resolve which snRNP particle PRP6 is a stable subunit of versus transiently associated with
    • Functional role of the zinc-finger-like and leucine repeat motifs in partner binding not directly demonstrated
  2. 1993 High

    Pinpointed the step in spliceosome assembly that requires PRP6, distinguishing tri-snRNP formation from di-snRNP maintenance.

    Evidence Glycerol gradient sedimentation and snRNA co-IP from heat-inactivated prp6-1 yeast extracts showing selective loss of [U4/U6.U5] tri-snRNP

    PMID:8479905

    Open questions at the time
    • Did not identify the direct protein-protein contacts mediating the bridging
    • Performed in yeast; human counterpart not yet shown
  3. 2005 High

    Defined the molecular bridging mechanism in humans by identifying the direct binding partners that link U5 to U4/U6.

    Evidence Protein sequencing, yeast two-hybrid, GST pulldowns, mass spectrometry of snRNP complexes, and immunoprecipitation showing PRPF6 (U5-102K) binds U4/U6-61K and U5-52K

    PMID:15840814

    Open questions at the time
    • Structural basis of the U4/U6-61K interaction not resolved
    • Timing/regulation of U5-52K dissociation during assembly not mechanistically dissected
  4. 2011 High

    Connected PRPF6 dysfunction to human disease, showing that a single missense mutation disrupts spliceosome recycling and causes inherited retinal degeneration.

    Evidence Mutation screening, confocal immunofluorescence of endogenous and GFP-tagged PRPF6 in patient lymphoblasts and HeLa cells, and RT-PCR for intron retention identifying p.Arg729Trp with Cajal body accumulation

    PMID:21549338

    Open questions at the time
    • Why retinal cells are selectively vulnerable to a ubiquitous splicing defect is unexplained
    • Whether mislocalization reflects impaired assembly versus recycling not distinguished
  5. 2014 High

    Showed that PRPF6's splicing function is co-opted in cancer, biasing isoform choice of growth-regulatory genes and creating a selective dependency.

    Evidence RNAi knockdown of PRPF6 versus other snRNP proteins, RNA-seq, proliferation assays, and in vivo tumor growth showing selective growth arrest and an oncogenic ZAK isoform shift

    PMID:24788092

    Open questions at the time
    • How PRPF6 levels achieve preferential splicing of a discrete gene subset rather than global change is unclear
    • Direct contribution of the ZAK isoform to the proliferation phenotype not isolated
  6. 2022 Medium

    Extended the splicing-driven oncogenic role to a specific downstream regulatory cascade in ovarian cancer.

    Evidence IHC, RT-PCR for isoforms, and in vitro/in vivo functional assays linking PRPF6 to SNHG16-L downregulation, CEBPB-mediated GATA3 derepression

    PMID:37303939

    Open questions at the time
    • Mechanistic chain relies partly on correlative transcript measurements without reconstitution
    • Single-lab study; direct PRPF6 control of SNHG16 splicing not shown biochemically

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis by which PRPF6 simultaneously engages U4/U6-61K and the U5 snRNP, and the rules governing its substrate isoform selectivity, remain unresolved.
  • No high-resolution structure of PRPF6 within the human tri-snRNP in the timeline
  • Determinants of which transcripts are preferentially spliced upon PRPF6 changes are uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140098 catalytic activity, acting on RNA 4 GO:0060090 molecular adaptor activity 1
Localization
GO:0005634 nucleus 1
Pathway
R-HSA-8953854 Metabolism of RNA 4
Partners
CD2BP2PRPF31
Complex memberships
U5 snRNP[U4/U6.U5] tri-snRNP

Evidence

Reading pass · 7 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1990 Yeast PRP6 (ortholog of human PRPF6) encodes a U4/U6 snRNP-associated protein required for pre-mRNA splicing; immunoprecipitation showed that PRP6 protein co-precipitates U4/U6 snRNAs, and in vitro splicing of extracts from temperature-sensitive prp6 mutants was defective. Immunoprecipitation of snRNAs with PRP6 antibodies; in vitro splicing assays in prp6 mutant extracts Molecular and cellular biology High 2147224
1990 Yeast PRP6 (ortholog of human PRPF6) encodes a 899 amino acid protein with repeated helix-loop-helix motifs and cysteine/histidine zinc finger-like motifs; directed mutagenesis of specific cysteine/histidine residues critically impairs PRP6 function, and the protein contains leucine repeat motifs potentially mediating protein–protein interactions. DNA sequencing, directed mutagenesis of conserved cysteine/histidine residues, functional complementation assays The EMBO journal High 2118103
1993 Yeast PRP6 protein (ortholog of human PRPF6) is required for the accumulation of the [U4/U6.U5] tri-snRNP but is not present in the U4/U6 di-snRNP particle; heat-inactivation of prp6-1 mutant extracts severely reduces tri-snRNP levels while U4/U6 snRNPs remain normally represented. Glycerol gradient sedimentation analysis of snRNP particles from prp6 temperature-sensitive mutant extracts; antibody co-immunoprecipitation of U4, U5, and U6 snRNAs Nucleic acids research High 8479905
2005 Human PRPF6 (U5-102K) is a component of the 20S U5 snRNP and plays an essential role in tri-snRNP formation; it directly interacts with the U4/U6-61K protein to bridge U5 and U4/U6 snRNPs. PRPF6 also physically interacts with U5-52K (CD2BP2) via the N-terminal two-thirds of U5-52K, but U5-52K dissociates upon tri-snRNP formation, suggesting PRPF6 functions in tri-snRNP assembly. Protein sequencing; yeast two-hybrid screening; GST pulldown assays; mass spectrometry-based identification of snRNP complexes; immunoprecipitation RNA (New York, N.Y.) High 15840814
2011 A missense mutation in PRPF6 (p.Arg729Trp) causes autosomal-dominant retinitis pigmentosa; patient lymphoblasts show abnormal nuclear localization of PRPF6, with accumulation in Cajal bodies rather than normal nuclear distribution, indicating impairment of tri-snRNP assembly or recycling. Expression of GFP-tagged mutant PRPF6 in HeLa cells reproduced this Cajal body accumulation. Patient cells also exhibited intron retention in pre-mRNAs with specific splicing signals. Mutation screening; confocal immunofluorescence microscopy of endogenous and GFP-tagged PRPF6 in patient lymphoblasts and HeLa cells; RT-PCR analysis of endogenous transcripts for intron retention American journal of human genetics High 21549338
2014 PRPF6 drives cancer cell proliferation as a member of the tri-snRNP spliceosome complex; inhibition of PRPF6 (but not other snRNP complex proteins) selectively abrogates growth in cancer cells with high tri-snRNP levels. Reduced PRPF6 alters constitutive and alternative splicing of a discrete number of genes including an oncogenic isoform of ZAK kinase, establishing PRPF6's role in cancer via preferential splicing of growth-related gene products. RNAi-mediated knockdown of PRPF6 and other spliceosomal proteins; high-resolution transcriptome (RNA-seq) analysis; cell proliferation assays; in vivo tumor growth assays Genes & development High 24788092
2022 PRPF6 promotes metastasis and paclitaxel resistance in ovarian cancer by inducing alternative splicing of SNHG16, causing downregulation of SNHG16-L isoform, which in turn releases inhibition of GATA3 transcription mediated by CEBPB, leading to upregulation of GATA3 expression. Immunohistochemistry; RT-PCR for transcript isoforms; in vitro and in vivo functional assays (proliferation, migration, drug resistance); mechanistic pathway analysis Oncology research Medium 37303939

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Developmental cell 542 22280891
2018 Hi-TOM: a platform for high-throughput tracking of mutations induced by CRISPR/Cas systems. Science China. Life sciences 321 30446870
2005 Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell 281 15797382
2006 Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection. Circulation research 215 16741159
1999 The TOM core complex: the general protein import pore of the outer membrane of mitochondria. The Journal of cell biology 173 10579717
2019 Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution. Nature structural & molecular biology 153 31740857
2001 Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors. Molecular and cellular biology 147 11259583
2006 Genetic and physiological characterization of tomato cv. Micro-Tom. Journal of experimental botany 146 16687436
2017 Cryo-EM Structure of the TOM Core Complex from Neurospora crassa. Cell 142 28802041
2001 Tom40, the pore-forming component of the protein-conducting TOM channel in the outer membrane of mitochondria. The Journal of cell biology 141 11402060
2006 Cytosolic factor- and TOM-independent import of C-tail-anchored mitochondrial outer membrane proteins. The EMBO journal 140 17110923
2001 Biogenesis of porin of the outer mitochondrial membrane involves an import pathway via receptors and the general import pore of the TOM complex. The Journal of cell biology 134 11266446
2010 Large-scale analysis of full-length cDNAs from the tomato (Solanum lycopersicum) cultivar Micro-Tom, a reference system for the Solanaceae genomics. BMC genomics 133 20350329
1999 Biogenesis of Tom40, core component of the TOM complex of mitochondria. The Journal of cell biology 128 10427088
2007 Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors. The Journal of biological chemistry 125 17974559
2011 Tomato TILLING technology: development of a reverse genetics tool for the efficient isolation of mutants from Micro-Tom mutant libraries. Plant & cell physiology 111 21965606
2020 Atomic structure of human TOM core complex. Cell discovery 110 33083003
2011 A missense mutation in PRPF6 causes impairment of pre-mRNA splicing and autosomal-dominant retinitis pigmentosa. American journal of human genetics 109 21549338
2009 Salinity induces carbohydrate accumulation and sugar-regulated starch biosynthetic genes in tomato (Solanum lycopersicum L. cv. 'Micro-Tom') fruits in an ABA- and osmotic stress-independent manner. Journal of experimental botany 105 19995825
2002 Protein translocase of the outer mitochondrial membrane: role of import receptors in the structural organization of the TOM complex. Journal of molecular biology 104 11866524
1990 The yeast PRP6 gene encodes a U4/U6 small nuclear ribonucleoprotein particle (snRNP) protein, and the PRP9 gene encodes a protein required for U2 snRNP binding. Molecular and cellular biology 103 2147224
2007 Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins. The Journal of cell biology 100 18039934
1997 The Tom and Tim machine. Current biology : CB 97 9081657
2007 The transmembrane segment of Tom20 is recognized by Mim1 for docking to the mitochondrial TOM complex. Journal of molecular biology 92 18187149
2022 Role of the TOM Complex in Protein Import into Mitochondria: Structural Views. Annual review of biochemistry 91 35287471
2021 Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex. Molecular cell 89 34875213
2004 Tom22', an 8-kDa trans-site receptor in plants and protozoans, is a conserved feature of the TOM complex that appeared early in the evolution of eukaryotes. Molecular biology and evolution 84 15155803
2009 Mitochondrial targeting of tBid/Bax: a role for the TOM complex? Cell death and differentiation 79 19521421
2014 An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth. Genes & development 78 24788092
1997 Immune suppression and Th1/Th2 balance in pregnancy revisited: a (very) personal tribute to Tom Wegmann. American journal of reproductive immunology (New York, N.Y. : 1989) 78 9228297
2018 Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis. Cell reports 77 30463002
1990 The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors. The EMBO journal 77 2118103
1995 TOM, a new aromatic degradative plasmid from Burkholderia (Pseudomonas) cepacia G4. Applied and environmental microbiology 74 7538275
2015 Sam37 is crucial for formation of the mitochondrial TOM-SAM supercomplex, thereby promoting β-barrel biogenesis. The Journal of cell biology 73 26416958
2001 Apocytochrome c requires the TOM complex for translocation across the mitochondrial outer membrane. The EMBO journal 72 11598006
2016 Ground control to major TOM: mitochondria-nucleus communication. The FEBS journal 71 27283924
2006 Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway. Developmental cell 69 16459304
2005 Mim1, a protein required for the assembly of the TOM complex of mitochondria. EMBO reports 69 15608614
1987 Establishment and characterization of a cell line, TOM-1, derived from a patient with Philadelphia chromosome-positive acute lymphocytic leukemia. Blood 68 3103721
2000 Recognition of preproteins by the isolated TOM complex of mitochondria. The EMBO journal 67 10990453
2002 Bcl-2 and porin follow different pathways of TOM-dependent insertion into the mitochondrial outer membrane. Journal of molecular biology 65 12419260
2007 The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release. The Journal of biological chemistry 64 17635912
2024 Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress. Proceedings of the National Academy of Sciences of the United States of America 63 38416681
1998 Dynamics of the TOM complex of mitochondria during binding and translocation of preproteins. Molecular and cellular biology 62 9710610
2002 Biogenesis of the mitochondrial TOM complex. Trends in biochemical sciences 59 11943546
1997 tom-1, a novel v-Myb target gene expressed in AMV- and E26-transformed myelomonocytic cells. The EMBO journal 59 9135152
2013 HIV-1 infection, response to treatment and establishment of viral latency in a novel humanized T cell-only mouse (TOM) model. Retrovirology 57 24156277
2022 Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors. Proceedings of the National Academy of Sciences of the United States of America 56 35733257
2001 Assembly of Tom6 and Tom7 into the TOM core complex of Neurospora crassa. The Journal of biological chemistry 55 11278536
2021 Mapping protein interactions in the active TOM-TIM23 supercomplex. Nature communications 53 34588454
2023 Molecular pathway of mitochondrial preprotein import through the TOM-TIM23 supercomplex. Nature structural & molecular biology 52 37696957
2011 Lateral release of proteins from the TOM complex into the outer membrane of mitochondria. The EMBO journal 52 21765393
2005 Role of Tom5 in maintaining the structural stability of the TOM complex of mitochondria. The Journal of biological chemistry 51 15701639
2020 From TOM to the TIM23 complex - handing over of a precursor. Biological chemistry 50 32074073
2014 Cooperation of TOM and TIM23 complexes during translocation of proteins into mitochondria. Journal of molecular biology 50 25083920
2005 The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation. RNA (New York, N.Y.) 50 15840814
2003 Comparison of the TIM and TOM channel activities of the mitochondrial protein import complexes. Biophysical journal 50 12719229
1994 The Drosophila tom retrotransposon encodes an envelope protein. Molecular and cellular biology 50 8035817
2004 Mitochondrial protein import. Requirement of presequence elements and tom components for precursor binding to the TOM complex. The Journal of biological chemistry 48 15337763
2003 Targeting and assembly of mitochondrial tail-anchored protein Tom5 to the TOM complex depend on a signal distinct from that of tail-anchored proteins dispersed in the membrane. The Journal of biological chemistry 48 12896971
1996 Identification of a third yeast mitochondrial Tom protein with tetratrico peptide repeats. FEBS letters 46 8612740
1988 Retrovirus-like features and site specific insertions of a transposable element, tom, in Drosophila ananassae. Molecular & general genetics : MGG 46 2851093
2025 Structure of human PINK1 at a mitochondrial TOM-VDAC array. Science (New York, N.Y.) 44 40080546
1993 The biochemical defects of prp4-1 and prp6-1 yeast splicing mutants reveal that the PRP6 protein is required for the accumulation of the [U4/U6.U5] tri-snRNP. Nucleic acids research 44 8479905
2013 Genome-wide analysis of intraspecific DNA polymorphism in 'Micro-Tom', a model cultivar of tomato (Solanum lycopersicum). Plant & cell physiology 43 24319074
2006 TOM: a web-based integrated approach for identification of candidate disease genes. Nucleic acids research 43 16845011
2017 Major Tom to Ground Control: How Lipoproteins Communicate Extracytoplasmic Stress to the Decision Center of the Cell. Journal of bacteriology 42 28674071
2002 A conserved proline residue is present in the transmembrane-spanning domain of Tom7 and other tail-anchored protein subunits of the TOM translocase. FEBS letters 42 11943179
2003 Mitochondrial protein import: recognition of internal import signals of BCS1 by the TOM complex. Molecular and cellular biology 41 12640110
2008 Localization of the Carnation Italian ringspot virus replication protein p36 to the mitochondrial outer membrane is mediated by an internal targeting signal and the TOM complex. BMC cell biology 40 18811953
2001 Structural requirements of Tom40 for assembly into preexisting TOM complexes of mitochondria. Molecular biology of the cell 39 11359915
2022 Mitochondrial protein translocation machinery: From TOM structural biogenesis to functional regulation. The Journal of biological chemistry 38 35346689
2000 Functional analysis of human metaxin in mitochondrial protein import in cultured cells and its relationship with the Tom complex. Biochemical and biophysical research communications 38 11027586
2024 ATAD1 prevents clogging of TOM and damage caused by un-imported mitochondrial proteins. Cell reports 35 39024102
2015 TOMATOMA Update: Phenotypic and Metabolite Information in the Micro-Tom Mutant Resource. Plant & cell physiology 35 26719120
2009 TOM-independent complex formation of Bax and Bak in mammalian mitochondria during TNFalpha-induced apoptosis. Cell death and differentiation 35 19165229
2008 The outer membrane form of the mitochondrial protein Mcr1 follows a TOM-independent membrane insertion pathway. FEBS letters 35 18279676
2012 The tomato (Solanum lycopersicum cv. Micro-Tom) natural genetic variation Rg1 and the DELLA mutant procera control the competence necessary to form adventitious roots and shoots. Journal of experimental botany 34 22915742
2024 Mechanism of human PINK1 activation at the TOM complex in a reconstituted system. Science advances 33 38848361
2021 The receptor subunit Tom20 is dynamically associated with the TOM complex in mitochondria of human cells. Molecular biology of the cell 32 34347503
2013 The PRP6-like splicing factor STA1 is involved in RNA-directed DNA methylation by facilitating the production of Pol V-dependent scaffold RNAs. Nucleic acids research 32 23877244
2003 Biogenesis of yeast mitochondrial cytochrome c: a unique relationship to the TOM machinery. Journal of molecular biology 32 12628251
2010 Molecular detection of Babesia bovis and Babesia bigemina in white-tailed deer (Odocoileus virginianus) from Tom Green County in central Texas. Veterinary parasitology 31 21194841
2018 Genome-wide transcriptomic analysis of BR-deficient Micro-Tom reveals correlations between drought stress tolerance and brassinosteroid signaling in tomato. Plant physiology and biochemistry : PPB 30 29723826
2013 Novel TPR-containing subunit of TOM complex functions as cytosolic receptor for Entamoeba mitosomal transport. Scientific reports 30 23350036
2004 Targeting and assembly of rat mitochondrial translocase of outer membrane 22 (TOM22) into the TOM complex. The Journal of biological chemistry 30 14985332
2022 Towards a molecular mechanism underlying mitochondrial protein import through the TOM and TIM23 complexes. eLife 29 35674314
2021 A Biochemical and Structural Understanding of TOM Complex Interactions and Implications for Human Health and Disease. Cells 29 34064787
2005 Expressed sequence tags from the laboratory-grown miniature tomato (Lycopersicon esculentum) cultivar Micro-Tom and mining for single nucleotide polymorphisms and insertions/deletions in tomato cultivars. Gene 29 15975739
2019 Triplet-pore structure of a highly divergent TOM complex of hydrogenosomes in Trichomonas vaginalis. PLoS biology 27 30608924
2019 Growth performance and gastrointestinal responses in heavy Tom turkeys fed antibiotic free corn-soybean meal diets supplemented with multiple doses of a single strain Bacillus subtilis probiotic (DSM29784)1. Poultry science 27 31180117
2015 The pro-apoptotic BH3-only protein Bim interacts with components of the translocase of the outer mitochondrial membrane (TOM). PloS one 26 25875815
2012 Enhancement of phytosterols, taraxasterol and induction of extracellular pathogenesis-related proteins in cell cultures of Solanum lycopersicum cv Micro-Tom elicited with cyclodextrins and methyl jasmonate. Journal of plant physiology 26 22608078
2009 The TOM complex is involved in the release of superoxide anion from mitochondria. Journal of bioenergetics and biomembranes 25 19690949
2022 The role of the individual TOM subunits in the association of PINK1 with depolarized mitochondria. Journal of molecular medicine (Berlin, Germany) 24 35391620
2023 Two conformations of the Tom20 preprotein receptor in the TOM holo complex. Proceedings of the National Academy of Sciences of the United States of America 23 37579144
2011 Ectopic expression of apple fruit homogentisate phytyltransferase gene (MdHPT1) increases tocopherol in transgenic tomato (Solanum lycopersicum cv. Micro-Tom) leaves and fruits. Phytochemistry 21 21256529
2020 The structure of the TOM core complex in the mitochondrial outer membrane. Biological chemistry 17 32142473
1983 The Tom Thumb dwarfing gene Rht3 in wheat : 2. Effects on height, yield and grain quality. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 16 24263924
2022 PRPF6 promotes metastasis and paclitaxel resistance of ovarian cancer via SNHG16/CEBPB/GATA3 axis. Oncology research 15 37303939

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