Affinage

TUB

Tubby protein homolog · UniProt P50607

Length
506 aa
Mass
55.7 kDa
Annotated
2026-06-10
56 papers in source corpus 14 papers cited in narrative 14 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TUB (Tubby) is an intracellular signaling adaptor and tyrosine-phosphorylation-regulated transcription factor that couples insulin and leptin receptor signaling to metabolic gene expression while also supporting ciliary protein trafficking (PMID:10455176, PMID:22966070, PMID:33213002). It is a direct substrate of the insulin receptor tyrosine kinase and of leptin receptor-JAK2, and in its phosphorylated state it engages SH2-domain proteins including Abl, Lck, and PLCγ, positioning it as an adaptor downstream of these receptors (PMID:10455176, PMID:22966070). Phosphorylation at Y464 triggers translocation of plasma-membrane TUB to the nucleus, an event modulated by nutritional status and blunted by high-fat diet through PTP1B (PMID:22966070, PMID:25031889). In the nucleus TUB controls metabolic and neuropeptide transcription: it interacts with STAT3 to potentiate leptin signaling in AgRP neurons (PMID:41671341), binds the promoters of insulin and beta-cell differentiation genes (ins1, ins2, pdx1, MafA) in concert with β-catenin (PMID:30290242), and drives NAMPT transcription downstream of TCR-PLCγ signaling to sustain NAD+-dependent T-cell metabolism (PMID:34380043). Through its conserved C-terminal tubby domain TUB binds PRCD and is required for correct trafficking of photoreceptor outer-segment cargo and for primary cilium biogenesis (PMID:33213002, PMID:36498982). Loss of TUB function causes maturity-onset obesity, leptin resistance, and apoptotic retinal and cochlear degeneration in mice and underlies a human syndrome of retinal dystrophy with early-onset obesity (PMID:10629044, PMID:24375934, PMID:41671341).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1999 High

    Established that TUB is not merely a phenotype-defining gene but a tyrosine-phosphorylated adaptor linking receptor tyrosine kinases to SH2-domain effectors.

    Evidence In vitro kinase assay with purified insulin receptor and reciprocal co-IP/SH2 binding in CHO-IR and PC12 cells

    PMID:10455176

    Open questions at the time
    • Did not establish which interactions operate in vivo
    • No nuclear/transcriptional role yet defined
    • Functional consequence of PLCγ association unresolved
  2. 2000 High

    Demonstrated the tubby mutation is loss-of-function and that TUB loss alone is sufficient for obesity plus apoptotic retinal/cochlear degeneration.

    Evidence Targeted knockout mouse with phenotypic comparison and TUNEL histology

    PMID:10629044

    Open questions at the time
    • Molecular mechanism linking loss to apoptosis not defined
    • Tissue-autonomous versus systemic effects not separated
  3. 2001 Medium

    Identified an upstream transcriptional regulator of TUB, showing thyroid hormone directly drives tub expression in brain.

    Evidence Hypothyroidism/T3 rescue in rats and T3 treatment of neuronal cultures with mRNA/protein readouts

    PMID:11415982

    Open questions at the time
    • Direct versus indirect transcriptional regulation not resolved
    • No promoter-level mechanism defined
  4. 2009 Medium

    Extended TUB's insulin-responsive adaptor role to adipocytes and linked its expression to insulin resistance.

    Evidence Co-IP and expression analysis in 3T3-L1 and obese Zucker rat adipocytes with rosiglitazone reversal

    PMID:19887065

    Open questions at the time
    • Causal role of TUB upregulation in insulin resistance unestablished
    • Single lab, correlative expression data
  5. 2012 High

    Defined TUB as a hypothalamic node integrating insulin and leptin signaling with nuclear translocation and neuropeptide gene control in vivo.

    Evidence ICV insulin/leptin in rats, ASO knockdown, nuclear fractionation, and neuropeptide expression analysis

    PMID:22966070

    Open questions at the time
    • Nuclear targets and direct DNA binding not yet mapped
    • Mechanism of membrane retention versus release unclear
  6. 2012 Medium

    Placed TUB in a shared photoreceptor-survival pathway with TULP1 functionally interacting with MTAP1A.

    Evidence Genetic modifier cross introducing an Mtap1a allele into Tub and Tulp1 mutant backgrounds with photoreceptor counts

    PMID:22323461

    Open questions at the time
    • Molecular basis of MTAP1A interaction unknown
    • Genetic epistasis without biochemical mechanism
  7. 2014 Medium

    Pinpointed Y464 as the insulin-activated phosphosite required for nuclear translocation, mechanistically coupling phosphorylation to relocalization.

    Evidence Y464 site-directed mutagenesis, confocal imaging, and kinase-inhibitor treatment in HIRcB cells

    PMID:25031889

    Open questions at the time
    • Single cell line and lab
    • Whether leptin uses the same site not addressed
  8. 2013 Medium

    Connected TUB to a human disease, showing a frameshift mutation mislocalizes the protein and co-segregates with retinal dystrophy and early-onset obesity.

    Evidence Autozygosity mapping, whole-exome sequencing, and localization of truncated protein

    PMID:24375934

    Open questions at the time
    • Single family
    • Mechanism linking mislocalization to both phenotypes not dissected
  9. 2018 Medium

    Revealed a nuclear transcription-factor function: TUB partners with β-catenin and binds beta-cell differentiation gene promoters to drive insulin production.

    Evidence Co-IP, ChIP at ins1/ins2/pdx1/MafA promoters, and immunofluorescence in pancreatic islet-derived MSCs

    PMID:30290242

    Open questions at the time
    • Direct versus cofactor DNA binding not resolved
    • Single cell model
  10. 2021 Medium

    Identified a distinct TUB transcriptional program controlling NAMPT/NAD+ metabolism downstream of TCR-PLCγ, governing T-cell metabolic fitness.

    Evidence Whole-genome CRISPR screen, metabolic tracing (LC-MS, isotopic labeling), and reporter assays in T cells

    PMID:34380043

    Open questions at the time
    • Direct TUB binding at the NAMPT locus not shown
    • Generalizability beyond tumor-infiltrating T cells unclear
  11. 2021 Medium

    Showed TUB acts in cochlear cell-fate, promoting Atoh1-mediated supporting-cell-to-hair-cell conversion in an Isl1/Tub/Znf532 pathway.

    Evidence Co-electroporation with Atoh1 in neonatal mouse cochlear explants with hair-cell marker readouts

    PMID:34819838

    Open questions at the time
    • Mechanism of TUB action in conversion undefined
    • Endogenous requirement versus overexpression effect not separated
  12. 2022 Medium

    Established a direct ciliary role, with biallelic inactivating variants destabilizing TUB and disrupting primary cilium biogenesis.

    Evidence Exome sequencing plus cilium morphology and protein-stability assays in patient-derived fibroblasts

    PMID:36498982

    Open questions at the time
    • Molecular role of TUB at the cilium unresolved
    • Single lab/patient-derived cells
  13. 2020 Medium

    Defined a tubby-domain-dependent cargo-trafficking function via direct PRCD binding required for photoreceptor outer-segment localization.

    Evidence Yeast two-hybrid, co-IP in mammalian cells, and immunolocalization in TUB-deficient mouse retina

    PMID:33213002

    Open questions at the time
    • Trafficking mechanism (direct carrier versus scaffold) unresolved
    • Single lab
  14. 2026 High

    Demonstrated TUB potentiates leptin signaling via direct STAT3 interaction in AgRP neurons, with a human variant impairing this interaction and conditional KO causing hyperphagic obesity.

    Evidence Human deep sequencing, knock-in and AgRP-conditional KO mice, TUB-STAT3 co-IP, and AgRP neuron electrophysiology

    PMID:41671341

    Open questions at the time
    • Whether STAT3 interaction is nuclear or cytoplasmic not fully resolved
    • Relationship to phosphorylation-dependent translocation not integrated

Open questions

Synthesis pass · forward-looking unresolved questions
  • How TUB's distinct activities — membrane adaptor, phosphorylation-gated transcription factor, and ciliary cargo-trafficking factor — are coordinated within a single protein and tissue context remains unresolved.
  • No structural model integrating tubby-domain trafficking with N-terminal transcriptional activity
  • Direct genome-wide DNA-binding map absent
  • Tissue-specific partner switching (STAT3 vs β-catenin vs PLCγ) not mechanistically explained

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 3 GO:0003677 DNA binding 1 GO:0060090 molecular adaptor activity 1
Localization
GO:0005634 nucleus 3 GO:0005886 plasma membrane 1 GO:0005929 cilium 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1430728 Metabolism 2 R-HSA-74160 Gene expression (Transcription) 2
Partners
ABL1CTNNB1INSRJAK2LCKPLCG1PRCDSTAT3

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 Tub is phosphorylated on tyrosine residues in response to insulin and IGF-1 in CHO-IR cells and PC12 cells. In vitro, Tub is phosphorylated by purified insulin receptor kinase as well as by Abl and JAK2, but not by EGF receptor or Src kinases. Upon tyrosine phosphorylation, Tub associates selectively with the SH2 domains of Abl, Lck, and the C-terminal SH2 domain of phospholipase Cγ; insulin enhanced the association of Tub with endogenous PLCγ in CHO-IR cells. These data suggest Tub functions as an adaptor protein linking the insulin receptor to SH2-containing proteins. In vitro kinase assay with purified insulin receptor kinase; transfection and immunoprecipitation in CHO-IR and PC12 cells; SH2 domain binding assays The Journal of biological chemistry High 10455176
2000 Targeted deletion of the tub gene recapitulates the full tubby phenotype (maturity-onset obesity, retinal and cochlear degeneration), establishing that the tubby mutation is a loss-of-function allele and that loss of Tub is sufficient for all observed phenotypes. Photoreceptor loss in tubby and tub-deficient mice occurs by apoptosis. Targeted gene deletion (knockout mouse); phenotypic comparison with tubby mutant mice; histological analysis including TUNEL assay Molecular and cellular biology High 10629044
2012 Tub is a substrate of both insulin receptor tyrosine kinase (IRTK) and leptin receptor (LEPR)-JAK2 in hypothalamic nuclei in vivo. Tub tyrosine phosphorylation is modulated by nutritional status. After insulin or leptin stimulation, Tub translocates to the nucleus. Inhibition of Tub expression in the hypothalamus by antisense oligonucleotides increased food intake, fasting blood glucose, and hepatic glucose output, decreased O2 consumption, and blunted the effect of insulin or leptin on neuropeptide expression (POMC, TRH, MCH, orexin). High-fat diet reduced leptin/insulin-induced Tub tyrosine phosphorylation and nuclear translocation, reversed by reducing PTP1B expression. Intracerebroventricular insulin/leptin injection in rats; antisense oligonucleotide knockdown; immunoprecipitation and Western blot for tyrosine phosphorylation; nuclear fractionation; neuropeptide expression analysis Diabetes High 22966070
2014 Tyrosine residue 464 of Tub is the specific phosphorylation site activated by insulin. Mutation of Y464 abolishes insulin-induced nuclear translocation of Tub. Major portions of Tub protein at the plasma membrane translocate to the nucleus after insulin treatment, and this translocation is blocked by tyrosine kinase inhibitor pretreatment, indicating phosphorylation is required for nuclear translocation. Site-directed mutagenesis of Y464; immunoprecipitation; confocal microscopy; Western blot; tyrosine kinase inhibitor treatment in HIRcB cells Endocrinology and metabolism (Seoul, Korea) Medium 25031889
2001 Thyroid hormone (T3) positively regulates tub gene expression in vivo and in vitro. Hypothyroidism in rats altered tub mRNA and protein levels in discrete brain areas, restored by T3/T4 treatment. T3 upregulated tub mRNA within 4–6 hours in neuronal cells in culture, indicating T3 is a direct positive regulator of tub expression. In vivo hypothyroidism/T3 treatment model in rats; in vitro neuronal cell culture with T3 treatment; Northern/Western blot analysis EMBO reports Medium 11415982
2009 TUB protein is expressed in rat adipocytes and murine 3T3-L1 adipocytes. Insulin induces TUB tyrosine phosphorylation and its association with the insulin receptor in adipocytes. TUB expression is regulated during adipogenic differentiation and is upregulated 5–10 fold in adipocytes from obese Zucker rats and insulin-resistant 3T3-L1 adipocytes, an effect antagonized by rosiglitazone. Western blot; immunoprecipitation; differentiation assays; insulin resistance induction in 3T3-L1 cells Biochemical and biophysical research communications Medium 19887065
2013 A homozygous frameshift mutation in TUB (c.1194_1195delAG) causes mislocalization of the truncated TUB protein in human patients, demonstrating that correct protein localization is functionally important and that loss of TUB is associated with retinal dystrophy and early-onset obesity. Autozygosity mapping, whole-exome sequencing, cellular localization studies of truncated protein Human mutation Medium 24375934
2020 TUB interacts physically with PRCD (photoreceptor disc component) via its conserved C-terminal tubby domain, as demonstrated by yeast two-hybrid and co-immunoprecipitation in transfected mammalian cells. PRCD localization was altered (mislocalized) in the retinas of TUB-deficient mice, indicating TUB is required for correct trafficking/localization of PRCD to photoreceptor outer segments. Ras recruitment system (yeast two-hybrid) on bovine retina cDNA library; co-immunoprecipitation in transfected mammalian cells; immunolocalization in TUB-deficient mice International journal of molecular sciences Medium 33213002
2018 In pancreatic islet-derived mesenchymal stem cells (PID-MSCs), TUB and β-catenin are linked to each other in the nucleus under insulin/leptin co-stimulation. TUB contributes to insulin production by binding to promoter regions of ins1, ins2, pdx1, and MafA genes, acting as a transcription factor in beta-cell differentiation signaling via the AKT/GSK-3β/β-catenin and Tub axis. Co-immunoprecipitation; chromatin immunoprecipitation (promoter binding assays); immunofluorescence; Western blot in PID-MSCs Biochimica et biophysica acta. Molecular cell research Medium 30290242
2021 TUB acts as a transcriptional factor whose activity depends on TCR-PLCγ signaling. TUB controls NAMPT transcription; reduced TUB activity in tumor-infiltrating T cells leads to low NAMPT expression, depleted intracellular NAD+, suppressed glycolysis, disrupted mitochondrial function, and dampened ATP synthesis, resulting in T cell dysfunction. Whole-genome CRISPR screen; metabolic inhibitor screen; LC-MS and isotopic labeling for NAD+ metabolism; transcriptional reporter assays Cell reports Medium 34380043
2022 Biallelic inactivating TUB variants lead to accelerated degradation of TUB protein and aberrant cilium morphology and biogenesis in patient-derived fibroblasts, demonstrating TUB is required for normal primary cilium biogenesis and structure. Exome sequencing; in vitro studies in patient-derived fibroblasts; immunofluorescence for cilium morphology and biogenesis markers; protein stability assays International journal of molecular sciences Medium 36498982
2021 TUB promotes Atoh1-mediated conversion of supporting cells to hair cells in neonatal mouse cochlear explants when co-electroporated with Atoh1, consistent with TUB being a downstream target of Isl1 in the Isl1/Tub/Znf532 pathway for hair cell regeneration. Electroporation of cochlear explants; overexpression of transcription factors; immunofluorescence for hair cell markers (Sox2+ progenitor conversion) Frontiers in cellular neuroscience Medium 34819838
2026 TUB acts as a positive regulator of the leptin signaling pathway through direct interaction with STAT3. The TUB p.R364G variant impairs TUB protein subcellular localization and disrupts TUB-STAT3 interaction. Conditional ablation of TUB in AgRP+ neurons leads to hyperphagic obesity and attenuated leptin-induced appetite suppression. TUB silencing mitigates the inhibitory effects of leptin on AgRP neuron activity. Deep sequencing in human cohort; knock-in mouse model (p.R363G); conditional knockout of TUB in AgRP+ neurons; co-immunoprecipitation for TUB-STAT3 interaction; food intake and leptin response assays; electrophysiology of AgRP neurons Science translational medicine High 41671341
2012 An allele of Mtap1a (microtubule-associated protein 1A) reduces photoreceptor degeneration in both Tulp1- and Tub-mutant mice, placing TUB and TULP1 in a common pathway that functionally interacts with MTAP1A in photoreceptor survival. Genetic QTL analysis; F2 intercross; transgenic modifier cross (Mtap1a allele introduced into Tub(tub/tub) background); histological photoreceptor counting Investigative ophthalmology & visual science Medium 22323461

Source papers

Stage 0 corpus · 56 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1990 Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse. The Journal of heredity 223 2250094
1997 Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. Proceedings of the National Academy of Sciences of the United States of America 120 9096357
2021 NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells. Cell reports 88 34380043
1997 Mycobacterium avium complex infection in an immunocompetent young adult related to hot tub exposure. Chest 88 8996025
1999 Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin. The Journal of biological chemistry 74 10455176
2000 Targeted deletion of the tub mouse obesity gene reveals that tubby is a loss-of-function mutation. Molecular and cellular biology 68 10629044
1999 Cell-specific expression of tubby gene family members (tub, Tulp1,2, and 3) in the retina. Investigative ophthalmology & visual science 62 10509669
2013 A homozygous mutation in the TUB gene associated with retinal dystrophy and obesity. Human mutation 57 24375934
1997 Progression of cochlear and retinal degeneration in the tubby (rd5) mouse. Audiology & neuro-otology 43 9390831
2018 RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection. PLoS pathogens 38 29912964
2001 Thyroid hormone regulates the obesity gene tub. EMBO reports 36 11415982
2010 The effect of hot-tub therapy on serum Hsp70 level and its benefit on diabetic rats: a preliminary report. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 32 20707652
1993 Hot tub legionellosis. Legionnaires' disease and Pontiac fever after a point-source exposure to Legionella pneumophila. Archives of internal medicine 32 8239853
2012 Tub has a key role in insulin and leptin signaling and action in vivo in hypothalamic nuclei. Diabetes 28 22966070
2004 Down-regulated expression of agouti-related protein (AGRP) mRNA in the hypothalamic arcuate nucleus of hyperphagic and obese tub/tub mice. Brain research. Molecular brain research 25 15193430
1983 tuf gene dosage effects on the intracellular concentration of EF-TuB. European journal of biochemistry 23 6337848
2006 Identification of TUB as a novel candidate gene influencing body weight in humans. Diabetes 22 16443771
2008 Polymorphisms of the TUB gene are associated with body composition and eating behavior in middle-aged women. PloS one 21 18183286
2012 An allele of microtubule-associated protein 1A (Mtap1a) reduces photoreceptor degeneration in Tulp1 and Tub Mutant Mice. Investigative ophthalmology & visual science 20 22323461
1992 Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7. Genomics 19 1358794
1987 Transfer of plasmid-borne tuf mutations to the chromosome as a genetic tool for studying the functioning of EF-TuA and EF-TuB in the E. coli cell. Biochimie 18 2964874
2004 Abnormal cholinergic and GABAergic vascular innervation in the hypothalamic arcuate nucleus of obese tub/tub mice. Synapse (New York, N.Y.) 15 15103691
2018 Tub and β-catenin play a key role in insulin and leptin resistance-induced pancreatic beta-cell differentiation. Biochimica et biophysica acta. Molecular cell research 14 30290242
2021 Lnc-OIP5-AS1 exacerbates aorta wall injury during the development of aortic dissection through upregulating TUB via sponging miR-143-3p. Life sciences 13 33577845
2019 TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles. Organic & biomolecular chemistry 11 30932115
2012 Identification of RD5-encoded Mycobacterium tuberculosis proteins as B-cell antigens used for serodiagnosis of tuberculosis. Clinical & developmental immunology 11 22701501
1996 Molecular mapping of the tubby (tub) mutation on mouse chromosome 7. Genomics 11 8833147
2004 Catabolic action of insulin in rat arcuate nucleus is not enhanced by exogenous "tub" expression. American journal of physiology. Endocrinology and metabolism 10 14749205
2009 Expression and modulation of TUB by insulin and thyroid hormone in primary rat and murine 3T3-L1 adipocytes. Biochemical and biophysical research communications 9 19887065
2007 TUB is a candidate gene for late-onset obesity in women. Diabetologia 9 17955208
2021 TUB and ZNF532 Promote the Atoh1-Mediated Hair Cell Regeneration in Mouse Cochleae. Frontiers in cellular neuroscience 8 34819838
2020 TULP1 and TUB Are Required for Specific Localization of PRCD to Photoreceptor Outer Segments. International journal of molecular sciences 8 33213002
2012 Species identification of Wickerhamomyces anomalus and related taxa using β-tubulin (β-tub) DNA barcode marker. Yeast (Chichester, England) 8 23172674
2007 Chlorophenol hydroxylase activity encoded by TfdB from 2,4-dichlorophenoxyacetic acid (2,4-D)-degrading Bradyrhizobium sp. strain RD5-C2. Bioscience, biotechnology, and biochemistry 8 17617713
1998 The murine tub (rd5) mutation is not associated with a primary axonemal defect. Cell and tissue research 8 9477305
2014 Insulin Phosphorylates Tyrosine Residue 464 of Tub and Translocates Tubby into the Nucleus in HIRcB Cells. Endocrinology and metabolism (Seoul, Korea) 7 25031889
2023 Identification of ACE I-Inhibitory Peptides Released by the Hydrolysis of Tub Gurnard (Chelidonichthys lucerna) Skin Proteins and the Impact of Their In Silico Gastrointestinal Digestion. Marine drugs 6 36827172
2021 Multiple Gene Clusters and Their Role in the Degradation of Chlorophenoxyacetic Acids in Bradyrhizobium sp. RD5-C2 Isolated from Non-Contaminated Soil. Microbes and environments 6 34511574
2006 A laboratory hot tub model for disinfectant efficacy evaluation. Journal of microbiological methods 6 16949693
2023 A novel homozygous TUB mutation associated with autosomal recessive retinitis pigmentosa in a consanguineous Chinese family. BMC medical genomics 5 36650547
2014 A case of hypercalcemia secondary to hot tub lung. Chest 5 25451359
2006 Mutation screen of the TUB gene in patients with retinitis pigmentosa and Leber congenital amaurosis. Experimental eye research 5 16643894
2017 In silico identification of cytotoxic T lymphocyte epitopes encoded by RD5 region of Mycobacterium tuberculosis. Journal of infection in developing countries 4 31600154
2009 Tubulin isotype specificity and identification of the epitope for antibody Tub 2.1. Protein engineering, design & selection : PEDS 4 19625384
2025 TUB-040, a Homogeneous and Hydrophilic NaPi2b-Targeting ADC with Stably Linked Exatecan, Exhibits Long-lasting Antitumor Activity and a Well-Tolerated Safety Profile. Molecular cancer therapeutics 3 40667801
2022 Biallelic Inactivating TUB Variants Cause Retinal Ciliopathy Impairing Biogenesis and the Structure of the Primary Cilium. International journal of molecular sciences 3 36498982
2018 Tub-Tag Labeling; Chemoenzymatic Incorporation of Unnatural Amino Acids. Methods in molecular biology (Clifton, N.J.) 3 29404991
2026 TUB-010, a Novel Anti-CD30 Antibody-Drug Conjugate Based on Tub-Tag Technology, Widens the Therapeutic Window by Reducing Toxicity While Maintaining High Efficacy. Molecular cancer therapeutics 1 40833272
2025 TUB-like protein 2, a substrate of CCT8, is essential for the intraflagellar transport during spermiogenesis in mice†. Biology of reproduction 1 40613306
2023 Histochemical research of enzymes involved in cellular digestion in the digestive tract of tub gurnard, Chelidonichthys lucerna. Fish physiology and biochemistry 1 37022661
2016 [Cutaneous lesions during hot-tub hypersensitivity pneumonitis: Pseudomonas folliculitis ?]. Annales de dermatologie et de venereologie 1 27823913
2008 [Isolation of sperm cells of Allium tub rosum Roxb]. Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology 1 18959007
2026 The TUB variant impairs leptin sensitivity and AgRP neuronal response, leading to obesity. Science translational medicine 0 41671341
2026 Widespread benzimidazole resistance and β-tub-1 F200Y SNP in gastrointestinal nematodes of sheep across Portugal. Veterinary parasitology 0 42025428
2020 Washing Machine Dynamic Model to Prevent Tub Collision during Transient State. Sensors (Basel, Switzerland) 0 33228133
2006 [A case of pulmonary Mycobacterium avium complex disease, mimicking hot tub lung]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 0 17233395

Missed literature

Know a paper Affinage missed for TUB? Flag it for the maintainers and the community.

No submissions yet.