Affinage

TTLL5

Tubulin polyglutamylase TTLL5 · UniProt Q6EMB2

Length
1281 aa
Mass
143.6 kDa
Annotated
2026-06-10
100 papers in source corpus 7 papers cited in narrative 7 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TTLL5 (STAMP/KIAA0998) is a tubulin tyrosine ligase-like polyglutamylase that installs glutamate side chains on specific substrates to control ciliary and flagellar function (PMID:23558686, PMID:27162334). Its best-defined catalytic role is the direct glutamylation of RPGR(ORF15), the photoreceptor-specific isoform of the retinitis pigmentosa GTPase regulator, within its α-tubulin-like Glu-Gly-rich repeat region; this substrate selectivity is conferred by a noncatalytic cofactor interaction domain unique to TTLL5 that engages the C-terminal basic domain of RPGR(ORF15), so that among TTLL family enzymes only TTLL5 modifies RPGR (PMID:27162334). Loss of TTLL5 abolishes RPGR glutamylation and causes cone opsin mislocalization and photoreceptor degeneration, and biallelic loss-of-function variants in humans cause cone, cone-rod, and macular dystrophies, with TTLL5 localizing to the centrioles/basal body at the base of the photoreceptor connecting cilium (PMID:27162334, PMID:24791901). In parallel, TTLL5 mediates a tissue-selective α-tubulin polyglutamylation of the sperm flagellar axoneme; its disruption in mice reduces sperm-tail tubulin polyglutamylation, disrupts axonemal doublet structure and motility, and causes male infertility, with the protein localizing to the spermatozoon flagellar centrosome (PMID:23558686, PMID:28173158). Independently of this catalytic activity, TTLL5/STAMP acts as a transcriptional comodulator that associates with the p160 coactivators TIF2 and SRC-1, colocalizes with and is recruited to promoters of glucocorticoid receptor-regulated genes, and forms a ternary complex with GR and TIF2 in which distinct domains independently tune maximal induction, agonist potency, and partial agonist activity (PMID:17116691, PMID:22342989); it also reduces cell proliferation in a steroid-independent manner (PMID:20374646).

Mechanistic history

Synthesis pass · year-by-year structured walk · 7 steps
  1. 2006 High

    Established TTLL5/STAMP's first known function as a steroid receptor coregulator, answering whether it participates in transcriptional control by linking it to p160 coactivators and GR-regulated genes.

    Evidence Co-IP, siRNA knockdown of endogenous STAMP, and ChIP at endogenous GR-regulated promoters with colocalization microscopy

    PMID:17116691

    Open questions at the time
    • Did not address any enzymatic/polyglutamylase activity
    • Mechanism of how STAMP alters coactivator function not resolved
  2. 2010 Medium

    Showed STAMP modulates cell growth independent of steroid signaling, indicating a physiological role beyond hormone-regulated transcription.

    Evidence Stable overexpression in HEK293 and siRNA knockdown across multiple ovarian cancer cell lines with proliferation readouts

    PMID:20374646

    Open questions at the time
    • Molecular basis of the growth effect unidentified
    • Cell-line-specific responses unexplained
  3. 2012 Medium

    Dissected how STAMP shapes GR transcriptional output, showing distinct domain interactions independently set maximal activity, potency, and partial agonist activity.

    Evidence Protein fragment transfections with reporter and endogenous gene assays measuring A_max/EC50/PAA in a GR-TIF2-STAMP ternary complex

    PMID:22342989

    Open questions at the time
    • Structural basis of the ternary complex not determined
    • Single lab; no orthogonal confirmation of independent parameter control
  4. 2013 High

    Defined the first catalytic in vivo role by showing TTLL5 drives tissue-selective sperm-tail α-tubulin polyglutamylation required for axonemal integrity and male fertility.

    Evidence Targeted mouse Stamp deletion with sperm axoneme EM, biochemical polyglutamylation quantification, and motility assays

    PMID:23558686

    Open questions at the time
    • Mechanism of tissue selectivity unexplained
    • Did not identify how polyglutamylation stabilizes doublets
  5. 2014 Medium

    Connected human retinal dystrophy to TTLL5 loss and placed the protein at the photoreceptor connecting cilium base, implicating ciliary polyglutamylation.

    Evidence Exome sequencing/case-control in retinal dystrophy patients with TTLL5 immunolocalization in human and murine retina

    PMID:24791901

    Open questions at the time
    • Direct substrate in photoreceptors not yet identified
    • Causal mechanism linking variants to degeneration not established
  6. 2016 High

    Identified RPGR(ORF15) as a direct, TTLL5-specific glutamylation substrate and defined the unique cofactor interaction domain underlying substrate targeting and disease.

    Evidence In vitro glutamylation assays, Co-IP, domain mapping, Ttll5 mutant mouse biochemistry/retinal phenotyping, and functional testing of human disease mutants

    PMID:27162334

    Open questions at the time
    • Stoichiometry/site mapping of RPGR glutamylation not resolved
    • How RPGR glutamylation supports opsin trafficking unknown
  7. 2016 Medium

    Unified the retinal and reproductive phenotypes by showing TTLL5 localizes to both the photoreceptor basal body and the sperm flagellar centrosome, with truncating variants associated with reduced fertility.

    Evidence NGS/autozygome screening with TTLL5 immunofluorescence in rat retina and human sperm plus patient motility analysis

    PMID:28173158

    Open questions at the time
    • Single lab localization
    • Did not biochemically confirm shared substrate across the two tissues

Open questions

Synthesis pass · forward-looking unresolved questions
  • How TTLL5's catalytic polyglutamylase activity and its noncatalytic role as a GR/p160 transcriptional comodulator are mechanistically and physiologically integrated remains unresolved.
  • No structural model of the cofactor interaction domain or the GR-TIF2-STAMP complex
  • Whether the proliferation and transcriptional roles depend on enzymatic activity is untested
  • No reconstituted polyglutamylation showing chain length/site preference

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 2 GO:0140110 transcription regulator activity 2 GO:0140096 catalytic activity, acting on a protein 1
Localization
GO:0005815 microtubule organizing center 2 GO:0005634 nucleus 1 GO:0005929 cilium 1
Pathway
R-HSA-74160 Gene expression (Transcription) 2 R-HSA-9709957 Sensory Perception 2 R-HSA-1474165 Reproduction 1
Partners
NR3C1RPGRSRC-1TIF2
Complex memberships
GR-TIF2-STAMP ternary complex

Evidence

Reading pass · 7 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 STAMP (TTLL5) was identified as a novel coregulator protein that associates with p160 coactivators TIF2 and SRC-1 and is selective for a subset of steroid/nuclear receptors including glucocorticoid receptors (GRs). Transfected STAMP increases TIF2 effects in GR-mediated repression and induction; siRNA knockdown of endogenous STAMP reduces both induction and repression of endogenous GR-regulated genes. Endogenous STAMP colocalizes with GR in intact cells and is recruited to promoters of GR-induced and -repressed genes. Co-immunoprecipitation, siRNA knockdown of endogenous STAMP, chromatin immunoprecipitation (ChIP) on endogenous gene promoters, colocalization by fluorescence microscopy Molecular and cellular biology High 17116691
2012 STAMP (TTLL5) forms a ternary complex with glucocorticoid receptor (GR) and coactivator TIF2. Different protein domains of GR, TIF2, and STAMP independently modulate the maximal activity (A_max), agonist potency (EC50), and partial agonist activity (PAA) of GR-mediated gene induction, demonstrating that these three parameters of transcriptional regulation can be independently controlled by distinct molecular interactions within the complex. Transfection of differentially sized protein fragments, reporter gene assays for A_max/EC50/PAA, endogenous gene assays Molecular and cellular endocrinology Medium 22342989
2010 STAMP (TTLL5) overexpression reduces the growth rate of HEK293 cells in a steroid-independent manner. siRNA knockdown of STAMP alters proliferation of ovarian cancer cell lines in a cell-line-specific manner, indicating a physiological role for STAMP in modulating cell growth rates independent of steroid hormone signaling. Stable transfection of STAMP in HEK293 cells (growth rate measurement), siRNA knockdown in multiple ovarian cancer cell lines (proliferation assay) BMC cancer Medium 20374646
2013 Disruption of the Ttll5/STAMP gene in male mice causes substantial reduction in α-tubulin polyglutamylation specifically in sperm tails, leading to abnormal axonemal structures with loss of tubulin doublets, defective progressive sperm motility, and male infertility. The defect in tubulin polyglutamylation was closely correlated with reduction in mutant STAMP mRNA levels. Axonemes in other tissues appeared unaffected, indicating a unique, tissue-selective TTLL5-mediated pathway for α-tubulin polyglutamylation required for sperm maturation. Targeted mouse knockout/internal deletion of Stamp gene; electron microscopy of sperm axonemes; biochemical measurement of α-tubulin polyglutamylation; sperm motility assays; RT-qPCR of TTLL genes The Journal of biological chemistry High 23558686
2016 TTLL5 directly glutamylates RPGR(ORF15) — a photoreceptor-specific isoform of the X-linked retinitis pigmentosa GTPase regulator — in its Glu-Gly-rich repetitive region containing motifs homologous to the α-tubulin C-terminal tail. The C-terminal basic domain of RPGR(ORF15) binds to a noncatalytic cofactor interaction domain unique to TTLL5 among TTLL family glutamylases, targeting TTLL5 specifically to RPGR. Only TTLL5, and not other TTLL family glutamylases, interacts with RPGR(ORF15) in cells. A Ttll5 mutant mouse shows complete loss of RPGR glutamylation without marked changes in tubulin glutamylation, and develops photoreceptor degeneration with early mislocalization of cone opsins resembling Rpgr-null mice. TTLL5 disease mutants causing human retinal dystrophy show impaired glutamylation of RPGR(ORF15). In vitro glutamylation assay; co-immunoprecipitation of TTLL5 and RPGR(ORF15); domain mapping (C-terminal basic domain of RPGR, cofactor interaction domain of TTLL5); Ttll5 mutant mouse biochemical analysis (anti-glutamylation immunoblot/immunofluorescence); retinal phenotyping (cone opsin localization, histology); functional analysis of disease-associated TTLL5 mutants Proceedings of the National Academy of Sciences of the United States of America High 27162334
2014 Biallelic loss-of-function variants in TTLL5 (encoding a tubulin glutamylase) cause cone, cone-rod, and macular dystrophies in humans. In human and murine retinae, TTLL5 localizes to the centrioles at the base of the connecting cilium of photoreceptors, consistent with a role in polyglutamylation of primary cilia. Exome sequencing and gene-based case-control association in retinal dystrophy patients; immunolocalization of TTLL5 in human and murine retinal sections American journal of human genetics Medium 24791901
2016 Mutations in TTLL5 in humans cause cone-rod degeneration and are associated with reduced male fertility in patients carrying truncating variants. TTLL5 protein localizes to the basal body of photoreceptor cells in rat retina and to the centrosome of the spermatozoon flagellum in humans, suggesting a common polyglutamylation mechanism in both cell types. Next-generation sequencing and autozygome-based screening; immunofluorescence localization of TTLL5 in rat retina and human sperm; sperm motility analysis in affected patients Human molecular genetics Medium 28173158

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. The Journal of experimental medicine 722 16061724
2007 STAMP: a web tool for exploring DNA-binding motif similarities. Nucleic acids research 371 17478497
2007 NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP). Molecular endocrinology (Baltimore, Md.) 369 17885208
2004 RANKL-induced DC-STAMP is essential for osteoclastogenesis. The Journal of experimental medicine 285 15452179
2021 A phase 3, open-label, randomized study of asciminib, a STAMP inhibitor, vs bosutinib in CML after 2 or more prior TKIs. Blood 248 34407542
2015 Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression. Acta pharmacologica Sinica 136 26592521
2007 Induction of DC-STAMP by alternative activation and downstream signaling mechanisms. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 111 17402846
2008 Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation. Journal of cellular physiology 110 18064667
2016 Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused by TTLL5 mutations. Proceedings of the National Academy of Sciences of the United States of America 98 27162334
2006 Role of DC-STAMP in cellular fusion of osteoclasts and macrophage giant cells. Journal of bone and mineral metabolism 97 16937266
2000 DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells. European journal of immunology 92 11169400
2012 Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 86 21987375
2015 The S-stamp in Descemet Membrane Endothelial Keratoplasty Safely Eliminates Upside-down Graft Implantation. Ophthalmology 85 26439215
2016 DC-STAMP: A Key Regulator in Osteoclast Differentiation. Journal of cellular physiology 84 27018136
2010 RANKL induces heterogeneous DC-STAMP(lo) and DC-STAMP(hi) osteoclast precursors of which the DC-STAMP(lo) precursors are the master fusogens. Journal of cellular physiology 83 20039274
2014 MiR-7b directly targets DC-STAMP causing suppression of NFATc1 and c-Fos signaling during osteoclast fusion and differentiation. Biochimica et biophysica acta 78 25123438
2014 Biallelic variants in TTLL5, encoding a tubulin glutamylase, cause retinal dystrophy. American journal of human genetics 77 24791901
2014 DC-STAMP, the key fusion-mediating molecule in osteoclastogenesis. Journal of cellular physiology 64 24420845
2021 Efficacy and safety of PXL770, a direct AMP kinase activator, for the treatment of non-alcoholic fatty liver disease (STAMP-NAFLD): a randomised, double-blind, placebo-controlled, phase 2a study. The lancet. Gastroenterology & hepatology 63 34560015
2015 Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology. PloS one 61 26042409
2011 CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 59 20721934
2013 Foreign body giant cells and osteoclasts are TRAP positive, have podosome-belts and both require OC-STAMP for cell fusion. Journal of cellular biochemistry 52 23444125
2013 Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility. The Journal of biological chemistry 52 23558686
2010 The stolbur phytoplasma antigenic membrane protein gene stamp is submitted to diversifying positive selection. Gene 50 21044666
2013 Caffeine enhances osteoclast differentiation and maturation through p38 MAP kinase/Mitf and DC-STAMP/CtsK and TRAP pathway. Cellular signalling 49 23434822
2013 Resolvin E1 regulates osteoclast fusion via DC-STAMP and NFATc1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 49 23629863
2000 Cardiac toxicity following high-dose cyclophosphamide, cisplatin, and BCNU (STAMP-I) for breast cancer. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 49 10816028
2013 Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. The Journal of experimental medicine 43 23980096
2006 The dendritic cell-specific transmembrane protein DC-STAMP is essential for osteoclast fusion and osteoclast bone-resorbing activity. Modern rheumatology 42 17164993
2019 High-throughput three-dimensional spheroid tumor model using a novel stamp-like tool. Journal of tissue engineering 40 31827757
2010 DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation. Molecular immunology 40 20546900
2020 Self-Healable Hydrogel-Liquid Metal Composite Platform Enabled by a 3D Printed Stamp for a Multimodular Sensor System. ACS applied materials & interfaces 39 31985196
2016 Mutations in the polyglutamylase gene TTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility. Human molecular genetics 39 28173158
1997 Identifying neuronal non-L Ca2+ channels--more than stamp collecting? Trends in pharmacological sciences 37 9357321
2018 OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 36 29533736
2020 Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors-A Possible Involvement of DC-STAMP. International journal of molecular sciences 35 32887359
2009 STAMP: Extensions to the STADEN sequence analysis package for high throughput interactive microsatellite marker design. BMC bioinformatics 35 19183437
2006 STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression. Molecular and cellular biology 35 17116691
2017 Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Regulates Osteoclast Differentiation via the Ca2+ /NFATc1 Axis. Journal of cellular physiology 34 27723141
2014 Pin1 regulates osteoclast fusion through suppression of the master regulator of cell fusion DC-STAMP. Journal of cellular physiology 33 24891219
2011 Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMP. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33 21990371
2008 The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function. International immunology 33 18653699
2023 STAMP-Based Digital CRISPR-Cas13a for Amplification-Free Quantification of HIV-1 Plasma Viral Loads. ACS nano 32 37252938
2019 Safety and Usefulness of Cryobiopsy and Stamp Cytology for the Diagnosis of Peripheral Pulmonary Lesions. Cancers 32 30909479
2010 Millimeter-scale contact printing of aqueous solutions using a stamp made out of paper and tape. Lab on a chip 32 20949218
2004 The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum. Journal of leukocyte biology 32 15601667
2017 DC-STAMP Is an Osteoclast Fusogen Engaged in Periodontal Bone Resorption. Journal of dental research 31 28199142
2015 It's more than stamp collecting: how genome sequencing can unify biological research. Trends in genetics : TIG 30 26003218
2024 Interpretable spatially aware dimension reduction of spatial transcriptomics with STAMP. Nature methods 29 39407016
2013 Mechanical vibration inhibits osteoclast formation by reducing DC-STAMP receptor expression in osteoclast precursor cells. Bone 29 23994170
2017 MiR-30a attenuates osteoclastogenesis via targeting DC-STAMP-c-Fos-NFATc1 signaling. American journal of translational research 28 29312525
2004 Socio-economic and behavioural factors are predictors of food use in the National Food Stamp Program Survey. The British journal of nutrition 28 15469654
2014 HIV: A stamp on the envelope. Nature 26 25296251
2012 The endothelial safety of using a gentian violet dry-ink "S" stamp for precut corneal tissue. Cornea 26 22262219
2015 Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization. Journal of cell science 24 26503158
2007 Time stamp in conditioned place avoidance can be set to different circadian phases. Neurobiology of learning and memory 24 17905603
2010 Stamp wound assay for studying coupled cell migration and cell debris clearance. Langmuir : the ACS journal of surfaces and colloids 23 20961056
1994 The use of minisatellite variant repeat-polymerase chain reaction (MVR-PCR) to determine the source of saliva on a used postage stamp. Journal of forensic sciences 23 8195763
2014 Comparison of periprosthetic tissues in knee and hip joints: differential expression of CCL3 and DC-STAMP in total knee and hip arthroplasty and similar cytokine profiles in primary knee and hip osteoarthritis. Osteoarthritis and cartilage 22 25151085
2008 OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation. Molecular immunology 22 18952287
2020 Oridonin ameliorates inflammation-induced bone loss in mice via suppressing DC-STAMP expression. Acta pharmacologica Sinica 21 32753731
2022 Melatonin Attenuates RANKL-Induced Osteoclastogenesis via Inhibition of Atp6v0d2 and DC-STAMP through MAPK and NFATc1 Signaling Pathways. Molecules (Basel, Switzerland) 20 35056817
2020 Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20 32707439
2023 Deciphering the mechanism of jujube vinegar on hyperlipoidemia through gut microbiome based on 16S rRNA, BugBase analysis, and the stamp analysis of KEEG. Frontiers in nutrition 19 37275638
2019 Validation of the Subjective Global Nutrition Assessment (SGNA) and Screening Tool for the Assessment of Malnutrition in Paediatrics (STAMP) to Identify Malnutrition in Hospitalized Malaysian Children. Journal of tropical pediatrics 19 29514329
2016 Sulforaphane inhibits osteoclast differentiation by suppressing the cell-cell fusion molecules DC-STAMP and OC-STAMP. Biochemical and biophysical research communications 18 27979663
2012 Short-term mechanical stress inhibits osteoclastogenesis via suppression of DC-STAMP in RAW264.7 cells. International journal of molecular medicine 18 23292096
2013 Safety evaluation of stamp type digital microneedle devices in hairless mice. Annals of dermatology 17 23467706
2011 DNA manipulation with elastomeric nanostructures fabricated by soft-moulding of a FIB-patterned stamp. Lab on a chip 17 21677946
2010 Molecules and signaling pathways involved in the expression of OC-STAMP during osteoclastogenesis. Amino acids 17 20882308
2021 Novel TTLL5 Variants Associated with Cone-Rod Dystrophy and Early-Onset Severe Retinal Dystrophy. International journal of molecular sciences 16 34203883
2013 Lentivirus-mediated RNA interference of DC-STAMP expression inhibits the fusion and resorptive activity of human osteoclasts. Journal of bone and mineral metabolism 16 23525827
2011 Tuning stamp surface energy for soft lithography of polar molecules to fabricate bioactive small-molecule microarrays. Small (Weinheim an der Bergstrasse, Germany) 16 21538866
2024 Oral Microbiome Stamp in Alzheimer's Disease. Pathogens (Basel, Switzerland) 15 38535538
2023 Combination Treatment with Sipuleucel-T and Abiraterone Acetate or Enzalutamide for Metastatic Castration-Resistant Prostate Cancer: STAMP and STRIDE Trials. Clinical cancer research : an official journal of the American Association for Cancer Research 15 37058234
2013 Differential expression and function of stamp family proteins in adipocyte differentiation. PloS one 15 23874564
2011 DC-STAMP knock-down deregulates cytokine production and T-cell stimulatory capacity of LPS-matured dendritic cells. BMC immunology 15 21978263
2023 Comparison of TRIBE and STAMP for identifying targets of RNA binding proteins in human and Drosophila cells. RNA (New York, N.Y.) 14 37169395
2014 "Stamp-off" to micropattern sparse, multicomponent features. Methods in cell biology 14 24439276
2013 Lysophosphatidic acid stimulates osteoclast fusion through OC-STAMP and P2X7 receptor signaling. Journal of bone and mineral metabolism 14 23624721
2021 OC-STAMP Overexpression Drives Lung Alveolar Epithelial Cell Type II Senescence in Silicosis. Oxidative medicine and cellular longevity 13 34426759
2025 STAMP: Single-cell transcriptomics analysis and multimodal profiling through imaging. Cell 12 40532697
2017 Intraoperative S-Stamp Enabled Rescue of 3 Inverted Descemet Membrane Endothelial Keratoplasty Grafts. Cornea 12 28410359
2002 The impact of induction duration and the number of high-dose cycles on the long-term survival of women with metastatic breast cancer treated with high-dose chemotherapy with stem cell rescue: an analysis of sequential phase I/II trials from the Dana-Farber/Beth Israel STAMP program. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 12 12017145
2020 STAMP: a multiplex sequencing method for simultaneous evaluation of mitochondrial DNA heteroplasmies and content. NAR genomics and bioinformatics 11 33134911
2017 Novel splice-site mutation in TTLL5 causes cone dystrophy in a consanguineous family. Molecular vision 11 28356705
2016 A Simple Method for Fabrication of Microstructures Using a PDMS Stamp. Micromachines 11 30404347
2012 Separate regions of glucocorticoid receptor, coactivator TIF2, and comodulator STAMP modify different parameters of glucocorticoid-mediated gene induction. Molecular and cellular endocrinology 11 22342989
2007 Added sugars displaced the use of vital nutrients in the National Food Stamp Program Survey. The Journal of nutrition 11 17237326
2023 Efficacy and safety of fluzoparib combined with anlotinib in extensive stage small cell lung cancer after first-line platinum-based chemotherapy: a multi-center, single-arm prospective phase II clinical study (STAMP study). BMC cancer 10 37580661
2011 All-silica nanofluidic devices for DNA-analysis fabricated by imprint of sol-gel silica with silicon stamp. Lab on a chip 10 22081085
2002 [Definitive ability of Stamp-staining, antigen-ELISA, PCR and cell culture for the detection of Coxiella burnetii]. Berliner und Munchener tierarztliche Wochenschrift 10 12357676
2024 Long-read Ribo-STAMP simultaneously measures transcription and translation with isoform resolution. Genome research 9 38906680
2023 Asciminib in chronic myeloid leukemia: a STAMP for expedited delivery? Haematologica 8 37102603
2022 Expanding the phenotype of TTLL5-associated retinal dystrophy: a case series. Orphanet journal of rare diseases 8 35365235
2022 TRIBE-STAMP reveals new insights into the functions of RNA binding proteins. Genes & development 8 36347558
2016 Serial multiple crossed immunoelectrophoresis at a microscale: A stamp-sized 2D immunoanalysis of protein C3 activation caused by nanoparticles. Electrophoresis 8 27387591
2010 Gymnasterkoreayne F inhibits osteoclast formation by suppressing NFATc1 and DC-STAMP expression. International immunopharmacology 8 20831919
2017 Sulforaphene attenuates multinucleation of pre-osteoclasts by suppressing expression of cell-cell fusion-associated genes DC-STAMP, OC-STAMP, and Atp6v0d2. Bioscience, biotechnology, and biochemistry 7 28136694
2010 STAMP alters the growth of transformed and ovarian cancer cells. BMC cancer 7 20374646

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