TRAPPC2B

TRAPPC2B (SEDLP1) is a transcribed retropseudogene located on chromosome 19q13.4 with the potential to encode a protein identical to SEDL/TRAPPC2 (PMID:11031107). In the available corpus, no direct mechanistic experiment has been performed on the TRAPPC2B protein itself; the only functional data concern its parent gene SEDL/TRAPPC2, whose tagged product localizes to perinuclear structures overlapping the ER-Golgi intermediate compartment and depends on its C-terminus for proper targeting (PMID:11031107). Beyond this incidental identification of TRAPPC2B as a transcribed pseudogene (PMID:11031107), no further mechanistic detail has been characterized in the available corpus.

1. 2000 Low

   Establishing whether the SEDL locus has paralogous copies, this work identified TRAPPC2B/SEDLP1 as a transcribed retropseudogene on chromosome 19q13.4 capable of encoding a protein identical to SEDL, while characterizing the parent SEDL protein's localization to the ER-Golgi intermediate compartment.

   Evidence Transient transfection of FLAG- and GFP-tagged SEDL constructs in Cos-7 cells with immunofluorescence localization; disease-mutation constructs implicating the C-terminus in targeting; genomic identification of the SEDLP1 pseudogene

   PMID:11031107

   Open questions at the time

   • No direct functional or localization experiment was performed on the TRAPPC2B protein itself
   • Whether the TRAPPC2B transcript is translated into a functional protein in vivo is unaddressed
   • All mechanistic claims (ERGIC localization, C-terminal targeting) pertain to the parent SEDL/TRAPPC2, not TRAPPC2B

• Whether TRAPPC2B encodes a functional protein and contributes to ER-to-Golgi transport independently of its parent gene remains unknown.
• No TRAPPC2B-specific protein expression, localization, or interaction data exist in the corpus
• No evidence on tissue-specific transcription or biological role of the pseudogene transcript