Affinage

TOMM6

Mitochondrial import receptor subunit TOM6 homolog · UniProt Q96B49

Round 2 corrected
Length
74 aa
Mass
8.0 kDa
Annotated
2026-04-28
61 papers in source corpus 21 papers cited in narrative 21 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TOMM6 is a small single-pass transmembrane subunit of the mitochondrial outer membrane TOM (translocase of the outer membrane) complex that stabilizes the Tom22–Tom40 interaction and promotes assembly of the mature ~400 kDa import pore, opposing the destabilizing activity of Tom7 (PMID:8641278, PMID:9774667). Structurally, Tom6 wraps around the Tom40 β-barrel channel as a transmembrane α-helix in the dimeric TOM core complex across species and contributes to docking the Tom20 receptor in the holo complex (PMID:28802041, PMID:33083003, PMID:39071881). The cytosolic precursor of Tom6 is phosphorylated by Cdk1–cyclin B during mitosis to stimulate its own mitochondrial import and enhance TOM complex assembly and respiratory capacity, and this phosphorylation is reversed by PP2A–Cdc55 on Ser16 (PMID:25378463, PMID:40891445). Elevated TOMM6 expression impairs PINK1/Parkin-mediated mitophagy in vascular smooth muscle cells, and TOMM6 aggregation is linked to mitochondrial dysfunction in a mouse Alzheimer's disease model (PMID:41232657, PMID:41895286).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1996 High

    Establishing the fundamental concept that Tom6 and Tom7 exert opposing regulatory effects on TOM complex stability resolved how small accessory subunits control the dynamics of a multisubunit translocase.

    Evidence Yeast single and double deletion mutants with co-immunoprecipitation, cross-linking, and radiolabeled preprotein import assays

    PMID:8641278

    Open questions at the time
    • Molecular basis of the stabilizing vs. destabilizing mechanism not defined
    • No structural information on Tom6's position within the complex
  2. 1998 High

    Demonstrating that Tom6 specifically promotes the Tom22–Tom40 interaction within the ~400 kDa GIP complex pinpointed Tom6's biochemical target within the translocase.

    Evidence Blue-native PAGE and co-immunoprecipitation in yeast tom6Δ mitochondria

    PMID:9774667

    Open questions at the time
    • Whether Tom6 contacts Tom22 directly or acts indirectly through Tom40 was unresolved
  3. 1999 High

    Isolation of the Neurospora TOM core complex (Tom40/22/6/7) and visualization of its twin-pore architecture established that Tom6 is an integral subunit of a functional channel capable of binding preproteins in a targeting-sequence-dependent manner.

    Evidence Detergent purification, planar lipid bilayer electrophysiology, and electron tomography 3D reconstruction

    PMID:10579717

    Open questions at the time
    • Subunit-level resolution within the pore not achieved
    • Individual contribution of Tom6 to channel conductance unknown
  4. 2001 High

    Mapping Tom6's entry point in TOM complex assembly—joining the 100 kDa Tom40 intermediate after Tom5 and before Tom7/Tom22—defined a sequential maturation pathway and placed Tom6 as an early assembly factor.

    Evidence In vitro import of radiolabeled precursors, BN-PAGE, and antibody-shift assays in yeast mutant mitochondria

    PMID:11259583 PMID:11276259 PMID:11278536

    Open questions at the time
    • Whether the same assembly order applies in mammalian cells was untested
    • The energetics driving each sequential step remained undefined
  5. 2008 High

    Two advances: (1) identification of human Tom6 as a bona fide component of the human TOM complex validated conservation from yeast, and (2) electrophysiology showed that Tom6 and other small subunits collectively modulate Tom40 channel gating dynamics at physiological voltages.

    Evidence Immunoisolation/MS from HeLa cells, siRNA knockdown import assays (human); planar lipid bilayer single-channel recordings comparing intact TOM core complex vs. isolated Tom40 (yeast/Neurospora)

    PMID:18331822 PMID:18456827

    Open questions at the time
    • Individual contribution of Tom6 to gating vs. other small subunits not dissected
    • Structural basis of gating modulation unknown
  6. 2009 High

    Genetic interaction between Tom6 and the SAM complex (Sam37) and demonstration that the SAM–Tom5/Tom40 subcomplex receives the Tom6 precursor after Mim1-dependent membrane insertion defined the upstream biogenesis pathway for Tom6 itself.

    Evidence Multicopy suppressor screens, yeast double-deletion mutants, BN-PAGE, co-IP, and in vitro import assays

    PMID:19797086 PMID:20026336

    Open questions at the time
    • How Mim1 recognizes the Tom6 transmembrane segment at a molecular level was unresolved
  7. 2014 High

    Discovery that Cdk1–cyclin B phosphorylates the cytosolic Tom6 precursor to stimulate its mitochondrial import during mitosis revealed a direct cell-cycle regulatory input into TOM complex biogenesis and mitochondrial respiratory capacity.

    Evidence In vitro and in vivo kinase assays, phosphomimetic/phosphodeficient mutants, import assays, BN-PAGE, respiratory measurements in yeast

    PMID:25378463

    Open questions at the time
    • The identity of the phosphatase counteracting Cdk1 was unknown
    • Relevance to mammalian mitotic control not tested
  8. 2017 High

    The ~10 Å cryo-EM structure of the Neurospora TOM core complex placed Tom6 as a transmembrane helix surrounding the Tom40 β-barrel, providing the first subunit-resolved architecture of the translocase.

    Evidence Single-particle cryo-EM and 3D reconstruction

    PMID:28802041

    Open questions at the time
    • Resolution insufficient for side-chain contacts
    • No structure of the holo complex with Tom20/Tom70 receptors
  9. 2019 High

    Phosphorylated Tom6 was shown to control the ratio of trimeric (Tom22-containing) to dimeric TOM complex, with Por1 sequestering released Tom22, thereby modulating substrate selectivity toward MIA-pathway clients—explaining how a single phosphorylation event rewires import specificity.

    Evidence BN-PAGE, co-IP, phosphomimetic Tom6 mutants, in vitro import assays in yeast

    PMID:30738703

    Open questions at the time
    • Whether this trimer–dimer switching occurs in mammalian cells is unknown
    • Structural basis of Por1-mediated Tom22 sequestration undefined
  10. 2020 High

    Atomic-resolution cryo-EM of the human TOM core complex confirmed the conserved arrangement of Tom6 around Tom40 and revealed electrostatic features of the translocation channel relevant to preprotein passage.

    Evidence Single-particle cryo-EM with atomic model building

    PMID:33083003

    Open questions at the time
    • Holo complex structure with receptors still missing at atomic resolution
  11. 2024 Medium

    A ~6 Å cryo-EM structure of the human TOM holo complex revealed that Tom6 participates in docking the Tom20 receptor, extending Tom6's role beyond core-complex stabilization to receptor organization.

    Evidence Chemical cross-linking stabilization of Tom20, single-particle cryo-EM

    PMID:39071881

    Open questions at the time
    • Limited resolution prevents defining precise Tom6–Tom20 contacts
    • Functional consequences of disrupting this interface not tested
  12. 2025 High

    Three advances completed the picture: (1) PP2A–Cdc55 was identified as the phosphatase that dephosphorylates Tom6-Ser16, closing the kinase–phosphatase cycle; (2) the Drosophila TOM structure at 3.3 Å confirmed the conserved Tom6 architecture; (3) TOMM6 was linked to disease-relevant mitochondrial quality control—aggregation in Alzheimer's disease models and impairment of PINK1/Parkin mitophagy in vascular calcification.

    Evidence Trap-peptide pulldown/MS and in vitro dephosphorylation (PP2A); ex vivo cryo-EM from Drosophila retina; transgenic AD mouse model with TOMM6 overexpression; siRNA/overexpression in VSMCs with mitophagy assays

    PMID:39575538 PMID:40891445 PMID:41232657 PMID:41895286

    Open questions at the time
    • Mechanistic link between TOM6 import function and mitophagy inhibition is biochemically unresolved
    • Whether TOMM6 aggregation in AD is causative or a downstream consequence is unclear
    • PP2A–Cdc55 as Tom6 phosphatase confirmed only in yeast; mammalian counterpart unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key open questions include: how Tom6 phosphorylation mechanistically switches TOM complex stoichiometry in mammalian cells; the structural basis of Tom6's role in modulating channel gating; and whether TOMM6-dependent mitophagy impairment represents a direct import-related mechanism or an indirect consequence of TOM complex remodeling.
  • No mammalian phospho-Tom6 functional studies
  • No high-resolution structure capturing Tom6 in the context of channel gating states
  • TOMM6–mitophagy link lacks reconstitution-level biochemical evidence

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 6
Localization
GO:0005739 mitochondrion 7
Pathway
R-HSA-9609507 Protein localization 6 R-HSA-1852241 Organelle biogenesis and maintenance 4 R-HSA-392499 Metabolism of proteins 4
Partners
MIM1SAM37TOMM20TOMM22TOMM40TOMM5TOMM7
Complex memberships
TOM core complex (TOM-CC)TOM holo complex

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 Tom6 (yeast) functions as an assembly factor for Tom22, promoting its stable association with Tom40 within the ~400 kDa general import pore (GIP) complex of the outer mitochondrial membrane. In tom6Δ mitochondria, the Tom22–Tom40 interaction is destabilized, releasing Tom22 and generating a ~100 kDa subcomplex of Tom40, Tom7, and Tom5. Yeast genetics (tom6Δ mutant), Blue-native PAGE, co-immunoprecipitation, biochemical fractionation of mitochondrial outer membrane complexes Molecular and cellular biology High 9774667
1996 Tom6 and Tom7 perform complementary and opposing functions in modulating TOM complex dynamics: Tom6 stabilizes the interaction between Tom22 and Tom40, whereas Tom7 exerts a destabilizing effect. Double-mutant (tom7Δ tom6Δ) synthetic growth defects provided genetic evidence for their functional relationship. Yeast genetics (single and double deletion mutants), co-immunoprecipitation, import assays with radiolabeled preproteins, in organello cross-linking The EMBO journal High 8641278
1999 The TOM core complex of Neurospora crassa, consisting of Tom40, Tom22, Tom6, and Tom7, was isolated and shown to contain high-conductance channels forming two open pores (~2.1 nm diameter) as determined by electron tomography 3D reconstruction. The complex binds preproteins in a targeting sequence-dependent manner. Detergent solubilization/purification, electrophysiology (planar lipid bilayer), electron tomography, 3D reconstruction, preprotein-binding assays The Journal of cell biology High 10579717
2001 During TOM complex assembly, Tom6 associates with the 100 kDa Tom40 intermediate (after Tom5 joins the 250 kDa intermediate), and maturation to the 400 kDa complex then occurs by association of Tom7 and Tom22. Tom6 thus acts at a specific sequential step in the assembly pathway. In vitro import assays with radiolabeled precursors, Blue-native PAGE, antibody-shift experiments, yeast mutant mitochondria Nature structural biology High 11276259
2001 In Neurospora crassa, Tom6 is in direct contact with Tom40 (shown by cross-linking) and interacts with Tom22 in a preprotein-dependent manner. The targeting and assembly information for Tom6 resides in its transmembrane segment and an adjacent N-terminal cytosolic flanking segment. Cross-linking, in vitro import/assembly assays, domain-swap hybrid constructs, competition assays The Journal of biological chemistry High 11278536
2001 Tom40 and Tom22 together form the functional core unit of the GIP complex that stably retains preproteins; Tom6 (along with Tom5 and Tom7) is released under stringent detergent conditions while the preprotein remains, indicating Tom6 stabilizes the complex but is not the primary preprotein-binding component. The GIP complex exhibits two coupled channel activities corresponding to two simultaneously active Tom40 pores. Urea/alkaline resistance assays, detergent titration, electrophysiology (TOM channel activity), outer membrane vesicle import assays Molecular and cellular biology High 11259583
2009 Tom6 genetically interacts with SAM complex component Sam37: overexpression of Tom6 suppresses sam37Δ growth defects, and the double mutant (tom6Δ sam37Δ) is inviable. This suppression is linked to Tom6's capacity to stabilize the essential beta-barrel protein Tom40. Multicopy suppressor screen, yeast genetics (deletion mutants, double knockouts), growth assays, BN-PAGE Molecular and cellular biology High 19797086
2009 The SAM complex forms two distinct large complexes with different functions in biogenesis of alpha-helical Tom proteins: a SAM-Tom5/Tom40 complex that binds the Tom6 precursor after Mim1-dependent insertion into the outer membrane, and a SAM-Mdm10 complex that handles Tom22. Tom6 assembly thus depends on prior Mim1-mediated membrane insertion. Co-immunoprecipitation, BN-PAGE, in vitro import assays, yeast deletion mutants Journal of molecular biology High 20026336
2010 Tom6 plays a stimulatory role (opposite to Tom7's inhibitory role) at an early stage of Tom40 assembly at the SAM complex. Tom5 and Tom6 together promote formation of the mature TOM complex, while Tom7 antagonizes this process at two distinct assembly steps. In vitro assembly assays, BN-PAGE, yeast deletion mutants, co-immunoprecipitation Journal of molecular biology High 21059357
2014 The cytosolic precursor of Tom6 is phosphorylated by cyclin Clb3-activated Cdk1 during mitosis, enhancing import of Tom6 into mitochondria. Tom6 phosphorylation promotes assembly of Tom40 into the TOM complex and import of fusion proteins, thereby stimulating respiratory activity of mitochondria in a cell cycle-specific manner. Kinase assays (Cdk1 phosphorylation of Tom6 precursor in vitro and in vivo), phosphomimetic/phosphodeficient mutants, import assays, BN-PAGE, respiratory activity measurements Science (New York, N.Y.) High 25378463
2008 Tom22, Tom7, Tom6, and Tom5 act as modulators of Tom40 pore dynamics: purified Tom40 alone shows gating only at high voltages, but the intact TOM core complex containing these small subunits significantly reduces the energy barrier between conformational states, enabling proper channel dynamics at physiological voltages. Planar lipid bilayer electrophysiology, single-channel recordings, purified TOM core complex vs. isolated Tom40 Biophysical journal High 18456827
2017 Cryo-EM structure of the Neurospora crassa TOM core complex at ~10 Å shows a symmetrical dimer of ten membrane protein subunits. Tom6 (together with Tom5 and Tom7) surrounds each Tom40 beta-barrel pore as transmembrane alpha-helical subunits; Tom22 connects the two Tom40 pores at the dimer interface. Single-particle cryo-electron microscopy, 3D reconstruction Cell High 28802041
2020 Atomic-resolution cryo-EM structure of the dimeric human TOM core complex (TOM-CC) shows that Tom6 (along with Tom5 and Tom7) surrounds the Tom40 beta-barrel channels in notable configurations. The complex has pronounced negative electrostatic features inside the channel and positive regions at the IMS periphery relevant to preprotein translocation. Single-particle cryo-EM, atomic model building Cell discovery High 33083003
2008 Human Tom5 and Tom6 were identified as components of the human TOM complex by immunoisolation of the TOM complex from HeLa cells expressing hTom22-FLAG followed by mass spectrometry. Human Tom6 is associated with Tom40. Knockdown of hTom40 decreases Tom6 levels; double knockdown of small Tom proteins (including Tom6) impairs preprotein import into the matrix. Immunoisolation (FLAG co-IP), mass spectrometry, siRNA knockdown, import assays, BN-PAGE Biochemical and biophysical research communications High 18331822
2019 Cell-cycle-dependent variation of phosphorylated Tom6 modulates the ratio of trimeric (Tom22-containing) to dimeric TOM complex: phosphorylated Tom6 promotes Tom22 integration into the trimeric TOM complex, and Por1 sequesters monomeric Tom22 that dissociates from the trimer, facilitating formation of the dimeric TOM complex preferred for import of TIM40/MIA-dependent proteins. Yeast genetics, co-immunoprecipitation, BN-PAGE, phosphomimetic/phosphodeficient Tom6 mutants, in vitro import assays Molecular cell High 30738703
2011 Tom6 facilitates the mitochondrial localization of specific mRNAs encoding mitochondrial proteins: deletion of TOM6 (tom6Δ) caused mislocalization of OXA1 mRNA (but not ATP2 mRNA) from mitochondria in yeast, establishing a role for this outer membrane translocase subunit in mRNA targeting. Live-cell fluorescence imaging of endogenously expressed mRNA reporters, quantitative colocalization analysis in deletion mutant strains RNA (New York, N.Y.) Medium 21705432
2025 PP2A (with regulatory subunit Cdc55) dephosphorylates Ser16 of Tom6 in vitro. Synthetic trap-peptides mimicking phospho-Tom6 enriched PP2A and PP4 as full holoenzymes from yeast cytosolic fractions, with PP2A–Cdc55 identified as the first phosphatase of the TOM complex. Synthetic trap-peptide pulldown from yeast cytosol, mass spectrometry identification of phosphatases, in vitro dephosphorylation assay with purified PP2A The FEBS journal High 40891445
2024 Cryo-EM structure of the human TOM holo complex (~6 Å resolution) reveals a single Tom20 subunit positioned at the center of the complex, stabilized by extensive interactions with Tom22, Tom40, and Tom6. Tom6 thus contributes to docking the Tom20 receptor in the holo complex. Chemical cross-linking to stabilize Tom20, single-particle cryo-EM PNAS nexus Medium 39071881
2025 Cryo-EM structure of the Drosophila melanogaster TOM complex (3.3 Å) shows Tom6 assembled as an endogenous subunit surrounding the Tom40 beta-barrel, with the Drosophila TOM architecture very similar to the human complex but with small conformational differences at subunit interfaces attributable to variation in lipid-binding residues. Single-particle cryo-EM, 3.3 Å molecular model from ex vivo Drosophila retinal TOM complex IUCrJ High 39575538
2025 In a mouse model of Alzheimer's disease, aggregated phospho-S670-GRK2 triggers aggregation of TOMM6 (human TOM6) and promotes mitochondrial dysfunction. Neuron-specific restoration of TOMM6 expression reduces beta-amyloid plaques but increases soluble beta-amyloid and mortality, indicating TOMM6 participates in mitochondrial quality control pathways relevant to neurodegeneration. Transgenic mouse models, Western blot for TOMM6 aggregation, neuron-specific TOMM6 overexpression, beta-amyloid quantification, survival analysis Cell reports. Medicine Medium 41895286
2025 NF-κB directly upregulates TOM6 transcription during vascular calcification; TOM6 knockdown attenuates calcification while TOM6 overexpression exacerbates it. Mechanistically, elevated TOM6 impairs PINK1/Parkin-mediated mitophagy and mitochondrial bioenergetics. Luteolin binds IKKα/IKKβ to inhibit NF-κB, suppressing TOM6 transcription and restoring mitophagy. siRNA knockdown and overexpression in VSMCs, in vivo VitD3-overload and CKD rat/mouse models, RNA sequencing, molecular docking (luteolin-IKK binding), mitophagy assays, Western blot for PINK1/Parkin pathway European journal of pharmacology Medium 41232657

Source papers

Stage 0 corpus · 61 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2003 The DNA sequence and analysis of human chromosome 6. Nature 242 14574404
2021 Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Cell metabolism 239 34800366
1998 Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex. Molecular and cellular biology 210 9774667
1999 The TOM core complex: the general protein import pore of the outer membrane of mitochondria. The Journal of cell biology 173 10579717
2001 Multistep assembly of the protein import channel of the mitochondrial outer membrane. Nature structural biology 165 11276259
2001 Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors. Molecular and cellular biology 145 11259583
2017 Cryo-EM Structure of the TOM Core Complex from Neurospora crassa. Cell 141 28802041
2001 Tom40, the pore-forming component of the protein-conducting TOM channel in the outer membrane of mitochondria. The Journal of cell biology 140 11402060
1996 Tom7 modulates the dynamics of the mitochondrial outer membrane translocase and plays a pathway-related role in protein import. The EMBO journal 137 8641278
2014 Mitochondria. Cell cycle-dependent regulation of mitochondrial preprotein translocase. Science (New York, N.Y.) 111 25378463
2011 Localization of mRNAs coding for mitochondrial proteins in the yeast Saccharomyces cerevisiae. RNA (New York, N.Y.) 111 21705432
2020 Atomic structure of human TOM core complex. Cell discovery 104 33083003
2009 Two modular forms of the mitochondrial sorting and assembly machinery are involved in biogenesis of alpha-helical outer membrane proteins. Journal of molecular biology 85 20026336
2010 Biogenesis of mitochondria: dual role of Tom7 in modulating assembly of the preprotein translocase of the outer membrane. Journal of molecular biology 74 21059357
2000 Recognition of preproteins by the isolated TOM complex of mitochondria. The EMBO journal 67 10990453
1998 Dynamics of the TOM complex of mitochondria during binding and translocation of preproteins. Molecular and cellular biology 62 9710610
2019 Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly. Molecular cell 58 30738703
2001 Assembly of Tom6 and Tom7 into the TOM core complex of Neurospora crassa. The Journal of biological chemistry 55 11278536
2014 Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1). FASEB journal : official publication of the Federation of American Societies for Experimental Biology 54 24448823
2005 Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. Proteomics 53 16097034
2005 Role of Tom5 in maintaining the structural stability of the TOM complex of mitochondria. The Journal of biological chemistry 50 15701639
2012 Pericellular pH homeostasis is a primary function of the Warburg effect: inversion of metabolic systems to control lactate steady state in tumor cells. Cancer science 48 22320183
2008 Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. Biochemical and biophysical research communications 47 18331822
2019 Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. iScience 45 31536960
2002 Characterization of Neurospora crassa Tom40-deficient mutants and effect of specific mutations on Tom40 assembly. The Journal of biological chemistry 42 12399467
2009 Genetic and functional interactions between the mitochondrial outer membrane proteins Tom6 and Sam37. Molecular and cellular biology 41 19797086
2003 Characterization of colletotrichum isolates from tamarillo, passiflora, and mango in Colombia and identification of a unique species from the genus. Phytopathology 35 18942980
2003 Biogenesis of yeast mitochondrial cytochrome c: a unique relationship to the TOM machinery. Journal of molecular biology 32 12628251
2000 The transport machinery for the import of preproteins across the outer mitochondrial membrane. The international journal of biochemistry & cell biology 32 10661891
2021 The receptor subunit Tom20 is dynamically associated with the TOM complex in mitochondria of human cells. Molecular biology of the cell 30 34347503
1990 Mapping of ripening-related or -specific cDNA clones of tomato (Lycopersicon esculentum). TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 29 24226453
2018 Regulation of autophagy by tea polyphenols in diabetic cardiomyopathy. Journal of Zhejiang University. Science. B 28 29732743
2015 A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. The Journal of biological chemistry 25 26272612
2014 Mitochondria represent another locale for the divalent metal transporter 1 (DMT1). Channels (Austin, Tex.) 25 25483589
2005 Transcriptome analysis of human gastric cancer. Mammalian genome : official journal of the International Mammalian Genome Society 24 16341674
2008 Dynamics of the preprotein translocation channel of the outer membrane of mitochondria. Biophysical journal 22 18456827
1994 Identification of genes overexpressed in tumors through preferential expression screening in trophoblasts. Cancer research 21 7923143
2020 BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A. Thoracic cancer 20 33001583
2020 MiR-378a-3p Is Critical for Burkitt Lymphoma Cell Growth. Cancers 19 33261009
2020 Structural snapshot of the mitochondrial protein import gate. The FEBS journal 18 33305524
2020 Analysis of lncRNA UCA1-related downstream pathways and molecules of cisplatin resistance in lung adenocarcinoma. Journal of clinical laboratory analysis 17 32249461
2005 Rpm2p, a component of yeast mitochondrial RNase P, acts as a transcriptional activator in the nucleus. Molecular and cellular biology 16 16024791
2010 LILBID-mass spectrometry of the mitochondrial preprotein translocase TOM. Journal of physics. Condensed matter : an Institute of Physics journal 14 21339618
2022 Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner. Cell death & disease 10 35941108
2019 Functional link between mitochondria and Rnr3, the minor catalytic subunit of yeast ribonucleotide reductase. Microbial cell (Graz, Austria) 8 31172013
2024 Structure of the intact Tom20 receptor in the human translocase of the outer membrane complex. PNAS nexus 7 39071881
2022 Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease. Life science alliance 6 35914814
2025 Structure of an ex vivoDrosophila TOM complex determined by single-particle cryoEM. IUCrJ 2 39575538
2025 Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids. Nature communications 2 40593736
2025 NF-κB/TOM6/PINK1-mediated mitophagy attenuates vascular calcification: Luteolin as a therapeutic modulator. European journal of pharmacology 2 41232657
2006 Peroxidase-like catalytic activity of Mn(3+)-octabromo-tetrakis(4-sulfophenyl)porphine on linoleate hydroperoxide and its analytical application. Talanta 2 19071327
2025 Integrative Proteome and Transcriptome Analyses Reveal the Metabolic Disturbance of the Articular Cartilage in Kashin-Beck Disease, an Endemic Arthritis. International journal of molecular sciences 1 40507958
2025 Synthetic trap-peptides identify a TOM complex phosphatase - PP2A dephosphorylates Tom6. The FEBS journal 1 40891445
2026 Analysis of GRK2 aggregation in the pathology of Alzheimer disease in animal models. Cell reports. Medicine 0 41895286
2026 Single-cell multi-omics sequencing reveals cell-specific transcriptomic and chromatin accessibility profiles in gut microbiome metabolite butyrate-produced pain modulation. International journal of oral science 0 41997906