Affinage

TOMM6

Mitochondrial import receptor subunit TOM6 homolog · UniProt Q96B49

Length
74 aa
Mass
8.0 kDa
Annotated
2026-06-10
42 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TOMM6 (Tom6) is a small α-helical transmembrane subunit of the mitochondrial outer-membrane TOM (translocase of the outer membrane) core complex, where it functions principally as an assembly and stability factor for the general import pore rather than as a component of the translocation channel itself (PMID:9774667, PMID:10579717). Within the complex, Tom6 is one of three small α-helical subunits (with Tom5 and Tom7) that surround each Tom40 β-barrel pore, a position confirmed in cryo-EM structures of the fungal, human, and Drosophila TOM complexes (PMID:28802041, PMID:33083003, PMID:39575538). Tom6 makes direct contact with Tom40 and engages Tom22 in a preprotein-dependent manner, promoting—but not maintaining—the stable Tom22–Tom40 association required for a functional pore; in its absence Tom22 dissociates and a Tom40/Tom7/Tom5 subcomplex accumulates (PMID:9774667, PMID:11278536). During Tom40 biogenesis, Tom6 is inserted into the outer membrane in an Mim1-dependent step and is then acquired by a SAM-bound Tom40/Tom5 intermediate, where it acts early to stimulate Tom40 assembly in direct antagonism to the inhibitory small subunit Tom7 (PMID:11276259, PMID:20026336, PMID:21059357). Tom6 and Tom7 thus exert opposing influences on TOM complex dynamics, stabilizing versus destabilizing receptor–channel interactions (PMID:8641278). Tom6 abundance and TOM stoichiometry are controlled by reversible phosphorylation: Clb3-activated Cdk1 phosphorylates the cytosolic Tom6 precursor to enhance its mitochondrial import, drive Tom22 integration and TOM trimer formation, and boost respiratory activity in a cell-cycle-dependent manner, while PP2A (via its Cdc55 regulatory subunit) dephosphorylates Ser16 to reverse this regulation (PMID:25378463, PMID:30738703, PMID:40891445). In human disease models TOMM6 has been linked to mitochondrial dysfunction, participating in a GRK2 aggregation pathway in Alzheimer disease and in an NF-κB/TOM6/PINK1 mitophagy axis driving vascular calcification (PMID:41895286, PMID:41232657).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1996 High

    Established that the small TOM subunits are not redundant but functionally opposed, with Tom6 stabilizing and Tom7 destabilizing receptor–channel interactions.

    Evidence Yeast double-mutant epistasis (synthetic growth defect) plus import assays and immunoprecipitation

    PMID:8641278

    Open questions at the time
    • Did not resolve the molecular basis of opposing dynamics
    • Did not separate assembly defects from steady-state pore function
  2. 1998 High

    Defined Tom6 as an assembly factor that promotes but does not maintain the stable Tom22–Tom40 association of the import pore, distinguishing assembly from channel function.

    Evidence Yeast deletion analysis with sucrose-gradient fractionation and immunoprecipitation of TOM components

    PMID:9710610 PMID:9774667

    Open questions at the time
    • Mechanism by which Tom6 promotes Tom22 docking not defined
    • Did not address dynamics during active translocation
  3. 1999 High

    Placed Tom6 structurally within a purified, channel-active TOM core complex, confirming it as a bona fide constituent of the import pore.

    Evidence TOM core complex purification, electron tomography, and lipid-bilayer electrophysiology in Neurospora

    PMID:10579717

    Open questions at the time
    • Low-resolution architecture only
    • Individual contribution of Tom6 to channel properties not isolated
  4. 2001 High

    Resolved the sequential assembly pathway, identifying Tom6 as an early-stage factor that joins a Tom40/Tom5 intermediate, and mapped the topological determinants for its own assembly.

    Evidence Radiolabeled precursor import/assembly assays, native gels, cross-linking, and domain-swap mutagenesis in yeast and Neurospora

    PMID:11259583 PMID:11276259 PMID:11278536

    Open questions at the time
    • Order of small-Tom incorporation relative to receptors not fully resolved
    • Did not identify membrane insertion machinery
  5. 2009 High

    Connected Tom6 assembly to the broader outer-membrane biogenesis machinery, showing Mim1-dependent insertion upstream and SAM-dependent acquisition during Tom40 maturation.

    Evidence Co-IP of assembly intermediates, BN-PAGE, and genetic deletion of SAM subunits and Mim1; multicopy suppressor genetics with SAM37

    PMID:19797086 PMID:20026336

    Open questions at the time
    • Direct physical Tom6–Mim1 interaction not demonstrated
    • Functional overlap with Sam37 mechanistically unresolved
  6. 2010 High

    Quantified the antagonism at the SAM assembly step, defining Tom5/Tom6 as stimulatory and Tom7 as inhibitory for mature TOM formation.

    Evidence Yeast genetic deletion, BN-PAGE, and radiolabeled precursor assembly assays

    PMID:21059357

    Open questions at the time
    • Structural basis of stimulation vs inhibition unknown
    • Kinetics of competing reactions not measured
  7. 2014 High

    Revealed that TOM assembly is dynamically regulated by the cell cycle through Cdk1/Clb3 phosphorylation of the Tom6 precursor, coupling mitochondrial import capacity to mitosis.

    Evidence Cyclin-Cdk1 kinase assays, phospho-mutant import assays, and mitochondrial respiratory measurements

    PMID:25378463

    Open questions at the time
    • Did not identify the dephosphorylating enzyme
    • Conservation of regulation in humans not tested
  8. 2019 High

    Mechanistically linked Tom6 phosphorylation state to TOM trimer/dimer equilibrium via Tom22 integration and Por1-mediated sequestration of dissociated Tom22.

    Evidence Co-IP, BN-PAGE, cell-cycle synchronization, and phospho-mimetic Tom6 mutants

    PMID:30738703

    Open questions at the time
    • Stoichiometric details of Por1–Tom22 sequestration unresolved
    • Physiological output of trimer vs dimer not fully defined
  9. 2020 High

    Provided atomic-resolution placement of Tom6 in the human TOM core complex, establishing structural conservation of its position around the Tom40 barrel.

    Evidence Single-particle cryo-EM of the dimeric human TOM core complex; complemented by Neurospora (2017) and Drosophila (2025) structures

    PMID:28802041 PMID:33083003 PMID:39575538

    Open questions at the time
    • Cytosolic precursor/phospho-regulated states not captured
    • Dynamic conformational transitions not resolved
  10. 2024 Medium

    Extended Tom6's role to receptor stabilization, showing it helps position and stabilize Tom20 within the holo complex.

    Evidence Cross-linking to trap Tom20 followed by ~6 Å cryo-EM of the human TOM holo complex

    PMID:39071881

    Open questions at the time
    • Moderate resolution; Tom6–Tom20 role inferred from contacts
    • Single study, not functionally validated
  11. 2025 High

    Identified PP2A/Cdc55 as the eraser that dephosphorylates Tom6 Ser16, completing the writer–eraser regulatory cycle of TOM phosphorylation.

    Evidence Synthetic trap-peptide phosphatase enrichment and in vitro dephosphorylation with purified PP2A holoenzyme; MS identification of regulatory subunits

    PMID:40891445

    Open questions at the time
    • In vivo cell-cycle role of PP2A on Tom6 not demonstrated
    • Single lab; specificity over other substrates not bounded
  12. 2025 Medium

    Implicated TOMM6 in mammalian disease pathways, linking it to GRK2-driven mitochondrial dysfunction in Alzheimer models and to an NF-κB/TOM6/PINK1 mitophagy axis in vascular calcification.

    Evidence Transgenic AD mouse with neuronal TOMM6 restoration; RNA-seq plus siRNA/overexpression in vascular smooth muscle cells with in vivo calcification models

    PMID:41232657 PMID:41895286

    Open questions at the time
    • Pathway placement is indirect
    • Whether disease roles reflect TOM-import function or other activity unclear
    • Single study per disease context
  13. 2011 Medium

    Suggested a role for Tom6 beyond protein import, in transcript-specific mitochondrial mRNA localization.

    Evidence Live-cell imaging of endogenously tagged mRNAs in tom6Δ yeast

    PMID:21705432

    Open questions at the time
    • Transcript-specific effect mechanistically unexplained
    • Single lab; relationship to import function unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Whether the Cdk1/PP2A phosphorylation cycle that governs Tom6-dependent TOM dynamics in yeast operates in mammalian cells, and how it intersects with the disease-associated mitophagy and aggregation pathways, remains open.
  • Human regulatory writer/eraser for TOMM6 not identified
  • Mechanistic link between TOM assembly regulation and disease phenotypes unestablished

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0005198 structural molecule activity 3 GO:0060090 molecular adaptor activity 3
Localization
GO:0005739 mitochondrion 3
Pathway
R-HSA-1852241 Organelle biogenesis and maintenance 3 R-HSA-392499 Metabolism of proteins 3 R-HSA-9609507 Protein localization 3
Partners
MIM1POR1SAM37TOMM20TOMM22TOMM40TOMM5TOMM7
Complex memberships
TOM core complexTOM holo complex

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 Tom6 (yeast) functions as an assembly factor for the TOM general import pore (GIP) complex: in mitochondria lacking Tom6, the interaction between Tom22 and Tom40 is destabilized, causing dissociation of Tom22 and generation of a ~100K subcomplex of Tom40, Tom7, and Tom5. Tom6 is required to promote but not to maintain the stable Tom22–Tom40 association. Yeast deletion mutant analysis, sucrose-gradient fractionation, immunoprecipitation of TOM complex components Molecular and cellular biology High 9774667
1998 Tom40 dynamically interacts with Tom6 during preprotein translocation; Tom40 exists in a homo-oligomeric assembly and the Tom40 assembly is influenced by Tom6, as shown by cross-linking and native complex analysis in both Neurospora crassa and S. cerevisiae. Chemical cross-linking, sucrose gradient sedimentation, native complex analysis Molecular and cellular biology High 9710610
1996 Tom6 and Tom7 perform complementary and opposing functions in modulating TOM complex dynamics: Tom6 stabilizes the interaction between receptors (Tom20, Tom22) and Tom40, while Tom7 destabilizes it. Synthetic growth defects in tom7Δ tom6Δ double mutants provide genetic evidence for their functional relationship. Yeast deletion genetics, double-mutant epistasis analysis, protein import assays, immunoprecipitation The EMBO journal High 8641278
1999 Tom6 is a constituent of the TOM core complex of Neurospora crassa (together with Tom40, Tom22, and Tom7), which forms a double-ring structure with two open pores (~2.1 nm diameter) that exhibits high-conductance channel activity and binds preprotein in a targeting sequence-dependent manner. Detergent solubilization, TOM core complex purification, electron tomography, planar lipid bilayer electrophysiology, preprotein binding assay The Journal of cell biology High 10579717
2001 Tom6 associates with a 100 kDa intermediate during the multistep assembly of the Tom40-containing GIP complex; this 100 kDa intermediate (Tom40 + Tom5) acquires Tom6 before maturation to the 400 kDa complex, identifying Tom6 as an early-stage assembly factor for Tom40 biogenesis. Radiolabeled precursor import assays, sucrose gradient sedimentation, native gel electrophoresis in yeast Nature structural biology High 11276259
2001 Tom6 (Neurospora crassa) is in direct contact with Tom40 (by cross-linking) and interacts with Tom22 in a manner dependent on the presence of transiting preproteins. The targeting and assembly information of Tom6 resides in its transmembrane segment and a flanking N-terminal cytosolic segment; both segments are required for assembly into the TOM complex. Chemical cross-linking, in vitro import/assembly assays, domain-swap hybrid protein analysis The Journal of biological chemistry High 11278536
2001 Tom40 and Tom22 together form the functional core unit of the GIP complex that stably retains accumulated preproteins; under stringent detergent conditions, Tom20 and all three small Tom proteins (including Tom6) are released while the preprotein remains in the Tom40–Tom22 core, demonstrating that Tom6 is dispensable for holding preproteins once import is initiated. Detergent fractionation, urea/salt treatment of arrested import intermediates, purified outer membrane vesicle import assays, electrophysiology Molecular and cellular biology High 11259583
2009 During Tom40 biogenesis, the SAM-Tom5/Tom40 subcomplex binds the precursor of Tom6 after Tom6 has been inserted into the outer membrane in an Mim1-dependent manner, identifying Tom6 assembly as downstream of Mim1-mediated membrane insertion and dependent on the SAM complex. Co-immunoprecipitation of assembly intermediates, BN-PAGE, genetic deletion analysis (SAM subunit and Mim1 mutants) in yeast Journal of molecular biology High 20026336
2009 Tom6 and Sam37 are functionally linked by genetic interaction: overexpression of TOM6 suppresses sam37Δ growth defects; overexpression of SAM37 suppresses tom6Δ; double deletion (tom6Δ sam37Δ) is lethal. Tom6 suppression of sam37Δ is linked to Tom6's ability to stabilize Tom40. Multicopy suppressor screen, yeast genetic analysis (single and double deletions), protein stability assays Molecular and cellular biology High 19797086
2010 Tom6 plays a stimulatory role at an early stage of Tom40 assembly at the SAM complex, antagonistic to Tom7's inhibitory role; Tom5 and Tom6 together promote formation of the mature TOM complex, while Tom7 opposes both Tom5 and Tom6 at this early assembly step. Yeast genetic deletion analysis, BN-PAGE, radiolabeled precursor import and assembly assays Journal of molecular biology High 21059357
2014 Cell-cycle-dependent regulation of TOM complex assembly involves Cdk1-mediated phosphorylation of the cytosolic precursor of Tom6: cyclin Clb3-activated Cdk1 phosphorylates Tom6, enhancing its import into mitochondria, promoting Tom40 assembly and import of fusion proteins, and stimulating mitochondrial respiratory activity in mitosis. In vivo phosphorylation assays, cyclin-Cdk1 kinase assay, import assays with phospho-mimetic/phospho-null Tom6 mutants, mitochondrial respiratory measurements Science (New York, N.Y.) High 25378463
2017 Cryo-EM structure of the TOM core complex from Neurospora crassa at near-atomic resolution shows Tom6 as one of three α-helical small subunits (alongside Tom5 and Tom7) surrounding each Tom40 β-barrel pore, contributing to the architecture of the symmetrical dimeric complex. Single-particle cryo-electron microscopy, structural modeling Cell High 28802041
2019 Cell-cycle-dependent variation of phosphorylated Tom6 modulates the trimeric TOM complex: phospho-Tom6 arising from Cdk1 activity promotes Tom22 integration into the TOM complex; porin Por1 sequesters Tom22 dissociated from trimeric TOM, and this sequestration is enhanced by the cell-cycle-controlled variation of phosphorylated Tom6, linking Tom6 phosphorylation state to TOM complex trimer/dimer equilibrium. Co-immunoprecipitation, BN-PAGE, in vivo cell-cycle synchronization, phospho-mimetic Tom6 mutants Molecular cell High 30738703
2020 Cryo-EM structure of the dimeric human TOM core complex shows that Tom6 is one of three small α-helical subunits surrounding the Tom40 β-barrel channels; Tom6 has a notable configuration contributing to the overall architecture and the electrostatic features of the complex. Single-particle cryo-electron microscopy, structural modeling Cell discovery High 33083003
2008 Small Tom proteins including Tom6 (along with Tom22, Tom7, and Tom5) act as modulators of TOM pore dynamics; isolated Tom40 alone (without these subunits) shows no transitions between conductance states at low voltages, whereas the full TOM core complex (containing Tom6) displays robust gating, indicating Tom6 and other small Toms reduce the energy barrier between conformational states. Planar lipid bilayer electrophysiology comparing purified Tom40 alone vs. TOM core complex Biophysical journal Medium 18456827
2024 In the human TOM holo complex structure, Tom6 stabilizes Tom20 through extensive interactions with Tom22, Tom40, and Tom6 itself; Tom20 is positioned at the center of the complex, stabilized in part by Tom6 contacts. Chemical cross-linking to stabilize Tom20, single-particle cryo-electron microscopy (~6 Å resolution) PNAS nexus Medium 39071881
2025 PP2A (protein phosphatase 2A), via its regulatory subunit Cdc55, dephosphorylates Ser16 of Tom6 in vitro. Synthetic trap-peptides enriched PP2A and PP4 as full holoenzymes from yeast cytosolic fractions, identifying PP2A as the first phosphatase (eraser) acting on TOM complex phosphorylation. Synthetic trap-peptide phosphatase enrichment from yeast cytosol, in vitro dephosphorylation assay with purified PP2A holoenzyme, mass spectrometry identification of regulatory subunits The FEBS journal High 40891445
2025 In an Alzheimer disease model, aggregated phospho-S670-GRK2 triggers aggregation of TOMM6 and promotes mitochondrial dysfunction; neuron-specific restoration of TOMM6 expression reduced beta-amyloid plaques but increased soluble beta-amyloid, indicating TOMM6 participates in a GRK2 aggregation-driven mitochondrial dysfunction pathway. Transgenic mouse AD model, neuronal TOMM6 overexpression, beta-amyloid quantification, mitochondrial function assays Cell reports. Medicine Medium 41895286
2025 Luteolin attenuates vascular calcification via the NF-κB/TOM6/PINK1 mitophagy axis: NF-κB drives TOM6 transcription; TOM6 knockdown attenuates calcification while overexpression exacerbates it; luteolin inhibits NF-κB nuclear translocation (by binding IKKα/IKKβ), suppresses TOM6 expression, and thereby enhances PINK1/Parkin-mediated mitophagy and improves mitochondrial bioenergetics. RNA sequencing, siRNA knockdown and overexpression of TOMM6 in vascular smooth muscle cells, in vivo mouse/rat calcification models, molecular docking (luteolin–IKK), Western blotting for mitophagy markers European journal of pharmacology Medium 41232657
2011 Tom6 facilitates mitochondrial mRNA localization in a transcript-specific manner: OXA1 mRNA (but not ATP2 mRNA) was mislocalized in tom6Δ yeast cells, suggesting Tom6 contributes to the localization of specific mRNAs to mitochondria. Live-cell fluorescence imaging of endogenously tagged mRNAs in tom6Δ yeast, quantitative colocalization analysis RNA (New York, N.Y.) Medium 21705432
2025 The Drosophila melanogaster TOM complex structure at 3.3 Å shows Tom6 as one of four endogenous TOM components (Tom22, Tom5, Tom6, Tom7) co-assembled with transgenic Tom40; the Drosophila and human TOM structures are very similar, with small conformational differences at subunit interfaces attributable to lipid-binding residue variation. Single-particle cryo-electron microscopy of ex vivo Drosophila TOM complex IUCrJ Medium 39575538

Source papers

Stage 0 corpus · 42 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1998 Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex. Molecular and cellular biology 212 9774667
1999 The TOM core complex: the general protein import pore of the outer membrane of mitochondria. The Journal of cell biology 173 10579717
2001 Multistep assembly of the protein import channel of the mitochondrial outer membrane. Nature structural biology 165 11276259
2001 Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors. Molecular and cellular biology 147 11259583
2017 Cryo-EM Structure of the TOM Core Complex from Neurospora crassa. Cell 142 28802041
2001 Tom40, the pore-forming component of the protein-conducting TOM channel in the outer membrane of mitochondria. The Journal of cell biology 141 11402060
1996 Tom7 modulates the dynamics of the mitochondrial outer membrane translocase and plays a pathway-related role in protein import. The EMBO journal 137 8641278
2014 Mitochondria. Cell cycle-dependent regulation of mitochondrial preprotein translocase. Science (New York, N.Y.) 113 25378463
2011 Localization of mRNAs coding for mitochondrial proteins in the yeast Saccharomyces cerevisiae. RNA (New York, N.Y.) 111 21705432
2020 Atomic structure of human TOM core complex. Cell discovery 110 33083003
2009 Two modular forms of the mitochondrial sorting and assembly machinery are involved in biogenesis of alpha-helical outer membrane proteins. Journal of molecular biology 86 20026336
2010 Biogenesis of mitochondria: dual role of Tom7 in modulating assembly of the preprotein translocase of the outer membrane. Journal of molecular biology 76 21059357
2000 Recognition of preproteins by the isolated TOM complex of mitochondria. The EMBO journal 67 10990453
1998 Dynamics of the TOM complex of mitochondria during binding and translocation of preproteins. Molecular and cellular biology 62 9710610
2019 Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly. Molecular cell 61 30738703
2014 Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1). FASEB journal : official publication of the Federation of American Societies for Experimental Biology 56 24448823
2001 Assembly of Tom6 and Tom7 into the TOM core complex of Neurospora crassa. The Journal of biological chemistry 55 11278536
2005 Role of Tom5 in maintaining the structural stability of the TOM complex of mitochondria. The Journal of biological chemistry 51 15701639
2012 Pericellular pH homeostasis is a primary function of the Warburg effect: inversion of metabolic systems to control lactate steady state in tumor cells. Cancer science 49 22320183
2002 Characterization of Neurospora crassa Tom40-deficient mutants and effect of specific mutations on Tom40 assembly. The Journal of biological chemistry 42 12399467
2009 Genetic and functional interactions between the mitochondrial outer membrane proteins Tom6 and Sam37. Molecular and cellular biology 41 19797086
2003 Characterization of colletotrichum isolates from tamarillo, passiflora, and mango in Colombia and identification of a unique species from the genus. Phytopathology 35 18942980
2000 The transport machinery for the import of preproteins across the outer mitochondrial membrane. The international journal of biochemistry & cell biology 33 10661891
2021 The receptor subunit Tom20 is dynamically associated with the TOM complex in mitochondria of human cells. Molecular biology of the cell 32 34347503
2003 Biogenesis of yeast mitochondrial cytochrome c: a unique relationship to the TOM machinery. Journal of molecular biology 32 12628251
1990 Mapping of ripening-related or -specific cDNA clones of tomato (Lycopersicon esculentum). TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 29 24226453
2018 Regulation of autophagy by tea polyphenols in diabetic cardiomyopathy. Journal of Zhejiang University. Science. B 28 29732743
2014 Mitochondria represent another locale for the divalent metal transporter 1 (DMT1). Channels (Austin, Tex.) 26 25483589
2008 Dynamics of the preprotein translocation channel of the outer membrane of mitochondria. Biophysical journal 22 18456827
2020 Structural snapshot of the mitochondrial protein import gate. The FEBS journal 19 33305524
2020 Analysis of lncRNA UCA1-related downstream pathways and molecules of cisplatin resistance in lung adenocarcinoma. Journal of clinical laboratory analysis 17 32249461
2005 Rpm2p, a component of yeast mitochondrial RNase P, acts as a transcriptional activator in the nucleus. Molecular and cellular biology 16 16024791
2010 LILBID-mass spectrometry of the mitochondrial preprotein translocase TOM. Journal of physics. Condensed matter : an Institute of Physics journal 14 21339618
2024 Structure of the intact Tom20 receptor in the human translocase of the outer membrane complex. PNAS nexus 9 39071881
2019 Functional link between mitochondria and Rnr3, the minor catalytic subunit of yeast ribonucleotide reductase. Microbial cell (Graz, Austria) 8 31172013
2025 Structure of an ex vivoDrosophila TOM complex determined by single-particle cryoEM. IUCrJ 2 39575538
2025 NF-κB/TOM6/PINK1-mediated mitophagy attenuates vascular calcification: Luteolin as a therapeutic modulator. European journal of pharmacology 2 41232657
2006 Peroxidase-like catalytic activity of Mn(3+)-octabromo-tetrakis(4-sulfophenyl)porphine on linoleate hydroperoxide and its analytical application. Talanta 2 19071327
2025 Integrative Proteome and Transcriptome Analyses Reveal the Metabolic Disturbance of the Articular Cartilage in Kashin-Beck Disease, an Endemic Arthritis. International journal of molecular sciences 1 40507958
2025 Synthetic trap-peptides identify a TOM complex phosphatase - PP2A dephosphorylates Tom6. The FEBS journal 1 40891445
2026 Analysis of GRK2 aggregation in the pathology of Alzheimer disease in animal models. Cell reports. Medicine 0 41895286
2026 Single-cell multi-omics sequencing reveals cell-specific transcriptomic and chromatin accessibility profiles in gut microbiome metabolite butyrate-produced pain modulation. International journal of oral science 0 41997906

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