Affinage

TMEM107

Transmembrane protein 107 · UniProt Q6UX40

Audit flag: rerun needed
Length
140 aa
Mass
15.5 kDa
Annotated
2026-04-28
39 papers in source corpus

Mechanistic narrative

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Mechanism profile

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Source papers

Stage 0 corpus · 39 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2011 A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nature cell biology 286 22179047
2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome research 285 12975309
2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Genomics 222 17207965
2017 RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. BMC biology 135 29117863
2015 TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome. Nature cell biology 108 26595381
2017 Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes. Journal of medical genetics 85 28289185
2009 Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice. Molecular vision 82 19727342
2014 Systematic identification of pathological lamin A interactors. Molecular biology of the cell 56 24623722
2022 NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia. Nature immunology 46 36138187
2012 Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling. Developmental biology 39 22698544
2015 Identification of a novel MKS locus defined by TMEM107 mutation. Human molecular genetics 38 26123494
2021 EGR1 dysregulation defines an inflammatory and leukemic program in cell trajectory of human-aged hematopoietic stem cells (HSC). Stem cell research & therapy 32 34294125
2020 MKS-NPHP module proteins control ciliary shedding at the transition zone. PLoS biology 31 32163404
2014 Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors. Molecular carcinogenesis 31 25213383
2012 Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. Biochimica et biophysica acta 30 23142642
2017 Ciliopathy Protein Tmem107 Plays Multiple Roles in Craniofacial Development. Journal of dental research 26 28954202
2023 Assessment of community efforts to advance network-based prediction of protein-protein interactions. Nature communications 22 36949045
2007 Aberrant splicing is a common mutational mechanism in MKS1, a key player in Meckel-Gruber syndrome. Human mutation 21 17437276
2015 TMEM107 Is a Critical Regulator of Ciliary Protein Composition and Is Mutated in Orofaciodigital Syndrome. Human mutation 19 26518474
2020 TMEM107 inhibits EMT and invasion of NSCLC through regulating the Hedgehog pathway. Thoracic cancer 17 33124203
2022 Mutations in SCNM1 cause orofaciodigital syndrome due to minor intron splicing defects affecting primary cilia. American journal of human genetics 14 36084634
2020 Tissue- and isoform-specific protein complex analysis with natively processed bait proteins. Journal of proteomics 11 32853754
2022 Systematic identification of NF90 target RNAs by iCLIP analysis. Scientific reports 9 35013429
2019 Loss of ciliary transition zone protein TMEM107 leads to heterotaxy in mice. Developmental biology 8 31887266
2023 Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid. Life science alliance 7 37863656
2023 Differential alternative splicing analysis links variation in ZRSR2 to a novel type of oral-facial-digital syndrome. Genetics in medicine : official journal of the American College of Medical Genetics 3 38158857
2023 A gene-based association test of interactions for maternal-fetal genotypes identifies genes associated with nonsyndromic congenital heart defects. Genetic epidemiology 2 37341229
2025 Identifying the anti-infection NK and T cell subgroups in preterm newborns with sepsis using single-cell RNA-seq analysis. European journal of medical research 1 41152979
2025 RETRACTION: TMEM107 Inhibits EMT and Invasion of NSCLC Through Regulating the Hedgehog Pathway. Thoracic cancer 0 40051292
2025 Establishment of a highly sensitive porcine alveolar macrophage cell line for African swine fever virus. In vitro cellular & developmental biology. Animal 0 40266442
2025 Expanding the phenotype associated with biallelic SCNM1 variants. Human genomics 0 41291844
2025 Molecular Spectrum and Deep Phenotyping of a Turkish Joubert Syndrome Cohort, Including a Potential Candidate Gene, NPHP4. Turkish archives of pediatrics 0 42044428