Affinage

TLE5

TLE family member 5 · UniProt Q08117

Length
197 aa
Mass
22.0 kDa
Annotated
2026-06-10
73 papers in source corpus 15 papers cited in narrative 15 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/7 claims corpus-supported (86%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TLE5/AES/GRG5 is a short, N-terminal Groucho-family transcriptional co-regulator that lacks the C-terminal WD-repeat domain present in full-length TLE/GRG proteins, functioning as a dynamic modulator that switches the output of multiple transcription factors rather than binding DNA itself (PMID:8365415). In epithelial cancers it acts predominantly as a repressor: it converts active RBPJ-Notch transcription complexes into repression complexes on the insoluble nuclear matrix to suppress Notch-driven transendothelial migration and metastasis (PMID:21251616), and it represses Wnt-mediated transcription through an interaction with TCF4 that specifically requires a 4-amino-acid LVPQ motif (PMID:23840876). This anti-metastatic activity extends to prostate cancer, where AES suppresses both androgen receptor and Notch transcriptional output and its epithelium-specific loss accelerates invasion and metastasis (PMID:28178391). AES stability is gated by CK1δ/ε-mediated phosphorylation at Ser121, which licenses SKP2-dependent ubiquitination and proteasomal degradation through Q-domain contacts with both kinase and ligase; the S121A mutant resists turnover and retains Wnt/Notch suppression (PMID:33754069). Beyond repression, AES enhances Runx2/Cbfa1 transcriptional activity and modulates Indian hedgehog signaling during skeletal development, with Grg5 loss reducing Ihh expression and impairing chondrocyte proliferation and bone formation (PMID:15183720, PMID:11984876). In hematopoietic contexts AES is co-opted by the AML1/ETO and NUP98-HOXA9 oncoproteins to drive self-renewal and proliferation (PMID:21245488, PMID:21937451). AES forms dynamic, HSC70-dependent nuclear foci together with TLE1 that dissolve during mitosis and reassemble after cytokinesis (PMID:26229111), and it promotes neuronal apoptosis that is counteracted by direct binding of the neuroprotective protein HDRP (PMID:18438919).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1993 Medium

    Establishing the molecular identity of AES as a truncated Groucho-family member defined the structural basis for its non-DNA-binding co-regulatory behavior.

    Evidence cDNA cloning and sequence alignment of mouse and human AES against Drosophila Groucho and TLE/GRG proteins

    PMID:8365415

    Open questions at the time
    • No functional consequence assigned to the absence of the WD-repeat domain at this stage
    • No interaction partners identified
  2. 2002 Medium

    Knockout phenotyping placed Grg5 in skeletal development, linking it to Indian hedgehog signaling and chondrocyte/bone formation.

    Evidence Gene-targeted knockout mice with histological growth-plate analysis and Ihh expression profiling

    PMID:11984876

    Open questions at the time
    • Pathway placement inferred from Ihh expression, not direct mechanistic reconstitution
    • No transcription factor partner identified to explain the Ihh effect
  3. 2004 High

    Identifying Runx2/Cbfa1 as a direct partner explained how AES exerts its skeletal role, as a positive co-activator confirmed by genetic epistasis.

    Evidence Yeast two-hybrid, transcriptional reporter assays, and Runx2+/- Grg5-/- compound mutant mice

    PMID:15183720

    Open questions at the time
    • Mechanism by which a Groucho protein enhances rather than represses Runx2 not resolved
    • Whether the Runx2 link directly accounts for the Ihh effect not established
  4. 2008 Medium

    Discovery of the HDRP interaction revealed AES as a pro-apoptotic factor in neurons whose lethal activity is antagonized by binding partners.

    Evidence Yeast two-hybrid, in vitro binding, Co-IP, and forced expression in cerebellar granule neurons

    PMID:18438919

    Open questions at the time
    • Transcriptional targets mediating AES-induced apoptosis unknown
    • Single lab; physiological relevance in vivo not tested
  5. 2011 High

    AES was defined as a Notch-pathway switch that suppresses cancer cell metastasis by remodeling RBPJ complexes on the nuclear matrix.

    Evidence Nuclear matrix fractionation, Apc-delta716 mouse genetics, and pharmacological Notch inhibition rescue

    PMID:21251616

    Open questions at the time
    • Molecular basis of the active-to-repressive complex conversion not detailed
    • Nuclear matrix tethering partners not fully defined
  6. 2011 Medium

    Parallel hematopoietic studies showed AES is hijacked by leukemic fusion oncoproteins to drive aberrant self-renewal, contrasting with its tumor-suppressive role in epithelia.

    Evidence Expression microarray and RNAi knockdown in AML1/ETO and NUP98-HOXA9 systems with colony-forming and primary cell proliferation assays

    PMID:21245488 PMID:21937451

    Open questions at the time
    • Transcriptional targets downstream of AES in leukemic self-renewal not mapped
    • How AES switches between repressive and oncogenic co-activator modes unresolved
  7. 2013 Medium

    Mapping the TCF4 interaction to an LVPQ motif explained the molecular specificity by which AES represses Wnt signaling.

    Evidence Co-IP, deletion mapping, luciferase reporters in human cells, and zebrafish gain/loss-of-function

    PMID:23840876

    Open questions at the time
    • Structural basis of LVPQ recognition not resolved
    • Whether other TCF isoforms are differentially affected in vivo not established
  8. 2015 Medium

    Live imaging defined AES nuclear foci as dynamic, cell-cycle-regulated structures requiring HSC70 chaperone activity.

    Evidence Electron microscopy, time-lapse cinematography, VER155008 inhibition, and subcellular fractionation

    PMID:26229111

    Open questions at the time
    • Functional consequence of focus formation for transcriptional output not established
    • Composition of foci beyond TLE1 and HSC70 unknown
  9. 2017 Medium

    Prostate cancer models extended AES anti-metastatic function to AR and Notch suppression, confirmed by tissue-specific knockout.

    Evidence Cell line over/knockdown, luciferase assays, xenograft and Aes/Pten compound knockout mice with IHC

    PMID:28178391

    Open questions at the time
    • Direct AES-AR physical interaction not demonstrated
    • Mechanism linking AES loss to Snail/MMP9 induction not defined
  10. 2021 High

    Identification of CK1δ/ε–SKP2–driven degradation established how AES protein levels are post-translationally controlled, with Ser121 as the regulatory switch.

    Evidence Reciprocal Co-IP, GST pull-down, S121A mutagenesis, and in vivo tumor/metastasis and PDTX models

    PMID:33754069

    Open questions at the time
    • Upstream signals activating CK1δ/ε toward AES not identified
    • Whether degradation is regulated differently across cell types not addressed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How AES is toggled between transcriptional repressor (Notch/Wnt in epithelia) and co-activator/oncogenic effector (Runx2, AML1/ETO, NUP98-HOXA9) remains the central unresolved question.
  • No unifying structural or biochemical model distinguishes repressive from activating complexes
  • Context determinants (partner availability, modification state) not defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 4 GO:0098772 molecular function regulator activity 3 GO:0060090 molecular adaptor activity 2
Localization
GO:0005634 nucleus 2
Pathway
R-HSA-1643685 Disease 4 R-HSA-162582 Signal Transduction 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1266738 Developmental Biology 2
Partners
CSNK1DHDRPHSPA8RBPJRUNX2SKP2TCF4TLE1
Complex memberships
AES/TLE1 nuclear fociRBPJ-Notch transcription complex

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2011 AES (GRG5) inhibits Notch signaling by converting active RBPJ transcription complexes into repression complexes on the insoluble nuclear matrix, thereby suppressing transendothelial migration of colon cancer cells triggered by Notch ligands on blood vessels. Biochemical fractionation (nuclear matrix), genetic depletion in Apc-delta716 mice, Notch signaling inhibition rescue experiments Cancer cell High 21251616
2021 CK1δ/ε phosphorylates AES at Ser121, which promotes SKP2-mediated ubiquitination and proteasomal degradation of AES via its Q domain interaction with CK1δ/ε and SKP2. The phosphorylation-deficient S121A mutant AES resists this degradation and retains its ability to suppress Wnt and Notch signaling in colon cancer cells. Co-immunoprecipitation, GST pull-down, Western blot, site-directed mutagenesis (S121A), in vivo tumor/metastasis models, PDTX models Theranostics High 33754069
2004 GRG5 (AES) physically interacts with the transcription factor Runx2-Cbfa1, identified by yeast two-hybrid, and enhances Runx2 transcriptional activity in cell culture assays. Genetic interaction was confirmed in Runx2+/- Grg5-/- compound mutant mice, which showed more severe ossification defects and reduced Ihh expression than Runx2+/- alone. Yeast two-hybrid, cell culture transcriptional assay, compound knockout mouse genetics (epistasis) Developmental biology High 15183720
2002 Grg5 null mice exhibit reduced Indian hedgehog (Ihh) expression and signaling in growth plates, shorter zones of proliferative and hypertrophic chondrocytes, and decreased trabecular bone formation, consistent with Grg5 modulating Ihh signaling during skeletal development. Gene-targeted knockout mice, histological analysis of growth plates, Ihh expression analysis Developmental dynamics Medium 11984876
2013 GRG5/AES interacts with TCF4 via a core region mapping to a 111-amino acid fragment of TCF4, and specifically requires a 4-amino acid LVPQ motif present only in TCF3 and some TCF4 isoforms (not shared with other GRGs). GRG5/AES represses Wnt-mediated transcription in human cells and in zebrafish embryos, and plays a role in dorsal-ventral patterning. Co-immunoprecipitation, deletion mapping, luciferase reporter assays (human cells), zebrafish overexpression/knockdown experiments PloS one Medium 23840876
2011 AES is upregulated by AML1/ETO in hematopoietic progenitor cells, and is required for AML1/ETO-induced self-renewal: RNAi knockdown of AES in AML1/ETO-expressing cell lines inhibited colony formation, and AES depletion in primary murine progenitors suppressed AML1/ETO-induced serial replating capacity. Expression microarray, RNAi knockdown in cell lines and primary murine progenitors, colony-forming unit assays, CFU-spleen assays Blood Medium 21245488
2008 HDRP (histone deacetylase-related protein) physically interacts with AES in the brain and blocks AES-induced neuronal apoptosis. Forced expression of AES in healthy cerebellar granule neurons causes cell death, which is prevented by co-expression of HDRP or TLE1. Yeast two-hybrid screen, in vitro binding assay, co-immunoprecipitation, co-localization, forced expression in cultured cerebellar granule neurons Journal of neuroscience research Medium 18438919
2011 AES physically interacts with the NUP98-HOXA9 oncoprotein (requiring the FG repeat region of NUP98-HOXA9) and with wild-type NUP98. AES augments NUP98-HOXA9 transcriptional activity and, in the presence of NUP98-HOXA9, increases long-term proliferation and primitive cell numbers in human CD34+ cells; these effects are not observed in the absence of NUP98-HOXA9. Cytoplasmic yeast two-hybrid, in vitro pulldown, co-immunoprecipitation, immunofluorescence, primary human CD34+ cell proliferation assays, AES knockdown The Journal of biological chemistry Medium 21937451
2015 AES (Aes) forms nuclear foci in colorectal cancer cells together with TLE1. These foci dissolve during mitosis and reassemble after cytokinesis. HSC70 is an essential component of Aes nuclear foci; pharmacological inhibition of HSC70 ATPase activity with VER155008 reduces Aes focus formation. Electron microscopy, time-lapse cinematography, pharmacological inhibition (VER155008), subcellular fractionation Journal of biochemistry Medium 26229111
2017 AES suppresses transcriptional activities of androgen receptor (AR) and Notch signaling in prostate cancer cells. In AR-defective cells, AES overexpression reduces invasion and metastasis to lymph nodes and bones. Prostate epithelium-specific Aes knockout in Pten-flox mice increased Snail and MMP9 expression and accelerated tumor invasion and lymph node metastasis. Overexpression/knockdown in human PCa cell lines, luciferase reporter assays, xenograft mouse model, compound knockout mice (Aes/Pten), immunohistochemistry Cancer science Medium 28178391
2016 Transcription factor YY2 directly binds the YY element in the CpG-island promoter-enhancer of the AES gene and stimulates AES expression in human colonic epithelial cells; downregulation of YY2 in liver metastases reduces AES expression. Promoter-enhancer mapping, transcription factor binding assays, transplantation mouse model, correlation of YY2 and AES protein levels in human CRC metastases Cancer science Low 27561171
2013 AES knockdown downregulates RND3 expression at mRNA and protein levels in cancer cell lines, and AES overexpression enhances RND3 promoter activity as shown by luciferase assay, suggesting AES positively regulates RND3 transcription. RNAi knockdown, luciferase promoter assay, Western blot, RT-PCR International journal of molecular medicine Low 23546594
2015 AES (Groucho protein) physically binds HNF1α and represses HNF1α-mediated transcription, with a direct functional link to glucose-stimulated insulin secretion in pancreatic beta-cells. Yeast two-hybrid (implied from 'identified as physical binding partner'), transcriptional reporter assay Biochemical and biophysical research communications Low 26549228
2018 GRG5 (AES) ablation in embryonic stem cells deregulates pluripotency, while overexpression enhances self-renewal. GRG5 represses mesendodermal-related genes and promotes neuroectodermal specification via suppression of Wnt and BMP signaling. GRG5 also maintains Neural Stem Cell self-renewal by sustaining Notch/Hes and Stat3 signaling activities. Loss- and gain-of-function ESC experiments, transcriptomic analysis, cell differentiation assays, neuronal reprogramming assays Scientific reports Low 30214018
1993 Mouse and human AES proteins (~202 and 197 amino acids, respectively) share approximately 50% amino acid identity with the N-terminal domain of Drosophila Groucho and full-length TLE/GRG proteins, establishing AES as a short, N-terminal fragment member of the Groucho family without the C-terminal WD-repeat domain. cDNA cloning, sequencing, sequence alignment European journal of biochemistry Medium 8365415

Source papers

Stage 0 corpus · 73 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 Cutaneous adverse events (AEs) of anti-programmed cell death (PD)-1 therapy in patients with metastatic melanoma: A single-institution cohort. Journal of the American Academy of Dermatology 247 26793994
2011 Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling. Cancer cell 180 21251616
1989 Auditory cortical projection from the anterior ectosylvian sulcus (Field AES) to the superior colliculus in the cat: an anatomical and electrophysiological study. The Journal of comparative neurology 117 2592605
1993 Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. European journal of biochemistry 67 8365415
1997 Characterization of the aes gene of Escherichia coli encoding an enzyme with esterase activity. Journal of bacteriology 55 9401025
2004 Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice. Developmental biology 53 15183720
1999 Determination of Cu, Fe, Mn, and Zn in blood fractions by SEC-HPLC-ICP-AES coupling. The Analyst 45 10616735
2003 Comparative evaluation of the VITEK 2 Advanced Expert System (AES) in five UK hospitals. The Journal of antimicrobial chemotherapy 41 12697635
2011 Proteomics of Pseudomonas aeruginosa Australian epidemic strain 1 (AES-1) cultured under conditions mimicking the cystic fibrosis lung reveals increased iron acquisition via the siderophore pyochelin. Journal of proteome research 40 22054071
2012 Proteomic profiling of Pseudomonas aeruginosa AES-1R, PAO1 and PA14 reveals potential virulence determinants associated with a transmissible cystic fibrosis-associated strain. BMC microbiology 38 22264352
2011 AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein. Blood 34 21245488
2009 Analysis of the plasma metalloproteome by SEC-ICP-AES: bridging proteomics and metabolomics. Expert review of proteomics 34 19489698
2012 RANKL in the osteolysis of AES total ankle replacement implants. Bone 33 22627031
2010 AES/GRG5: more than just a dominant-negative TLE/GRG family member. Developmental dynamics : an official publication of the American Association of Anatomists 32 20925119
2002 The Aes protein directly controls the activity of MalT, the central transcriptional activator of the Escherichia coli maltose regulon. The Journal of biological chemistry 30 11867639
2002 Growth defect in Grg5 null mice is associated with reduced Ihh signaling in growth plates. Developmental dynamics : an official publication of the American Association of Anatomists 29 11984876
2021 The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer. Theranostics 27 33754069
2000 Speciation of aluminium in forest soil extracts by size exclusion chromatography with UV and ICP-AES detection and cation exchange fast protein liquid chromatography with ETAAS detection. The Science of the total environment 27 11007289
2008 Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction. Journal of neuroscience research 26 18438919
2019 Dengue virus is an under-recognised causative agent of acute encephalitis syndrome (AES): Results from a four year AES surveillance study of Japanese encephalitis in selected states of India. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 25 30641206
2016 Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2. Cancer science 24 27561171
2013 Secretome of transmissible Pseudomonas aeruginosa AES-1R grown in a cystic fibrosis lung-like environment. Journal of proteome research 22 23991618
1977 Fast detoxification of heroin addicts by acupuncture and electrical stimulation (AES) in combination with naloxone. Comparative medicine East and West 22 610976
1991 Contribution to Zn-speciation in human breast milk: fractionation of organic compounds by HPLC and subsequent Zn-determination by DCP-AES. Journal of trace elements and electrolytes in health and disease 18 1822333
2020 Determination of heavy metals in cancerous and healthy colon tissues using laser induced breakdown spectroscopy and its cross-validation with ICP-AES method. Journal of pharmaceutical and biomedical analysis 17 32058289
2000 Quantification of the metal distribution in metallothioneins of the human liver by HPLC coupled with ICP-AES. Fresenius' journal of analytical chemistry 17 11227573
1998 Possibilities for speciation of Al-citrate and other negatively charged Al complexes by anion-exchange FPLC-ICP-AES. Talanta 16 18967147
2017 Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer. Cancer science 15 28178391
2016 Quantification of immobilized Candida antarctica lipase B (CALB) using ICP-AES combined with Bradford method. Enzyme and microbial technology 15 28010778
2007 A nanoparticle-based solution DNA sandwich assay using ICP-AES for readout. Biomacromolecules 12 17696396
2002 The Aes protein and the monomeric alpha-galactosidase from Escherichia coli form a non-covalent complex. Implications for the regulation of carbohydrate metabolism. The Journal of biological chemistry 12 12374803
2013 Suppression of RND3 activity by AES downregulation promotes cancer cell proliferation and invasion. International journal of molecular medicine 11 23546594
2013 GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos. PloS one 11 23840876
2011 Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability. The Journal of biological chemistry 11 21937451
2009 aes, the gene encoding the esterase B in Escherichia coli, is a powerful phylogenetic marker of the species. BMC microbiology 11 20040078
2023 Performance of the Vitek 2 Advanced Expert System (AES) as a Rapid Tool for Reporting Antimicrobial Susceptibility Testing (AST) in Enterobacterales from North and Latin America. Microbiology spectrum 10 36645286
2014 Simultaneous observation of the metabolism of cisplatin and NAMI-A in human plasma in vitro by SEC-ICP-AES. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 10 24458238
2018 Groucho related gene 5 (GRG5) is involved in embryonic and neural stem cell state decisions. Scientific reports 9 30214018
2017 Structural and SAXS analysis of Tle5-Tli5 complex reveals a novel inhibition mechanism of H2-T6SS in Pseudomonas aeruginosa. Protein science : a publication of the Protein Society 9 28758353
2003 Oral glutamine (AES-14) supplementation inhibits PI-3k/Akt signaling in experimental breast cancer. JPEN. Journal of parenteral and enteral nutrition 9 14621121
2015 Characterization of Aes nuclear foci in colorectal cancer cells. Journal of biochemistry 7 26229111
2015 Autoinflammation Around AES Total Ankle Replacement Implants. Foot & ankle international 6 26219907
2013 Structural and mutational analyses of Aes, an inhibitor of MalT in Escherichia coli. Proteins 6 23934774
2023 Can in vitro studies aid in the development and use of antiseizure therapies? A report of the ILAE/AES Joint Translational Task Force. Epilepsia 5 37642296
2021 AES and ToF-SIMS combination for single cell chemical imaging of gold nanoparticle-labeled Escherichia coli. Chemical communications (Cambridge, England) 5 33950059
2020 Determination of the Cellular Ion Concentration in Saccharomyces cerevisiae Using ICP-AES. Bio-protocol 5 33659389
2008 [Determination of mineral elements in brown rice of near-isogenic lines population for Japonica rice by ICP-AES]. Guang pu xue yu guang pu fen xi = Guang pu 5 19248524
2010 [Mineral elements analysis of Momordica charantiap seeds by ICP-AES and fatty acid profile identification of seed oil by GC-MS]. Guang pu xue yu guang pu fen xi = Guang pu 4 20939353
2003 Crystallization and preliminary X-ray diffraction studies of Aes acetyl-esterase from Escherichia coli. Acta crystallographica. Section D, Biological crystallography 4 14501134
2022 Optimization of AES-128 Encryption Algorithm for Security Layer in ZigBee Networking of Internet of Things. Computational intelligence and neuroscience 3 35498166
2019 Alkaline earth silicate (AES) wools: Evaluation of potential cyto-genotoxic and inflammatory effects on human respiratory cells. Toxicology in vitro : an international journal published in association with BIBRA 3 31002973
2015 Repression of HNF1α-mediated transcription by amino-terminal enhancer of split (AES). Biochemical and biophysical research communications 3 26549228
2015 Characterization of Klebsiella isolates by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and determination of antimicrobial resistance with VITEK 2 advanced expert system (AES). Turkish journal of medical sciences 3 26775392
2004 Crystallization and preliminary X-ray analysis of Aes, an acetyl-esterase from Escherichia coli. Acta crystallographica. Section D, Biological crystallography 3 14993683
2004 [Study on the determination of calcium in Chinese medicine by ICP-AES]. Guang pu xue yu guang pu fen xi = Guang pu 3 15760036
2024 Metabolism of alcohol ethoxylates (AEs) in rat, hamster, and human hepatocytes and liver S9: a pilot study for metabolic stability, metabolic pathway, and metabolites identification in vitro and in silico. Archives of toxicology 2 38844554
2023 A double encryption protection algorithm for stem cell bank privacy data based on improved AES and chaotic encryption technology. PloS one 2 37878640
2021 Clinical Impact of Switching to Ceritinib After Severe AEs Related to Crizotinib/Alectinib in a Novel PTH2R-ALK Fusion Lung Adenocarcinoma: A Case Report. OncoTargets and therapy 2 34992382
2007 Biochemical and thermostability features of acetyl esterase Aes from Escherichia coli. Protein and peptide letters 2 17305603
1996 [Radiosensitivity and postradiation kinetics of megakaryocyte release of the bone marrow (analysis based on data of the Chernobyl AES accident sequelae)]. Radiatsionnaia biologiia, radioecologiia 2 8673221
2010 [Construction and pathogenic identification of aes-31 gene mutant of avian pathogenic Escherichia coli strain E058]. Wei sheng wu xue bao = Acta microbiologica Sinica 1 21365924
1997 [Health status of persons with acute radiation sickness caused by Chernobyl AES accident]. Radiatsionnaia biologiia, radioecologiia 1 9417309
1994 [Hydration and structural state of liver DNA of rats exposed to radiation in the Chernobyl AES zone]. Radiatsionnaia biologiia, radioecologiia 1 8069363
1991 [Results of experimental radiobiological studies made within the 10-kilometer zone of the Chernobyl AES accident]. Radiobiologiia 1 1719579
2025 Investigating the Therapeutic Property of Galium verum L. (GV) for MSG induced Audiogenic Epilepsy (AEs) and Neuroprotection through In-Silico and In-Vitro Analysis. Central nervous system agents in medicinal chemistry 0 39253919
2009 [Study on ultrasonic nebulizer sample feeding system for ICP-AES]. Guang pu xue yu guang pu fen xi = Guang pu 0 19839351
2004 [Evaluation of the consequences of stress factors on plant seeds growing in a 30-km zone of Balakovo AES]. Radiatsionnaia biologiia, radioecologiia 0 15060947
1998 [Determination of mutation frequency at loci of glycophorin A and T-cell receptor: study of Chernobyl AES accident cleanup workers]. Radiatsionnaia biologiia, radioecologiia 0 9633619
1998 [Study of immune status indices, levels of alpha-1-thymosin and autoantibodies to thymic epithelial cells in persons who worked in the 30-kilometer zone of the Chernobyl AES depending on the radiation dose]. Radiatsionnaia biologiia, radioecologiia 0 9633624
1998 Genomic organization and chromosome localization to band 19p13.3 of the human AES gene: gene product exhibits strong similarity to the N-terminal domain of Drosophila enhancer of Split Groucho protein. DNA and cell biology 0 9809752
1994 [Actual nutrition of schoolchildren living in territories affected by the Chernobyl AES accident]. Voprosy pitaniia 0 7975418
1992 [Results of the cytogenetic examination of the people taking part in the clean-up of the accident at the Chernobyl AES]. Radiobiologiia 0 1448555
1991 [Clinico-immunocytological characteristics of leukemia in persons exposed to ionizing radiation effects due to the Chernobyl AES accident]. Vestnik Akademii meditsinskikh nauk SSSR 0 1950155

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