Affinage

TGM1

Protein-glutamine gamma-glutamyltransferase K · UniProt P22735

Length
817 aa
Mass
89.8 kDa
Annotated
2026-06-10
100 papers in source corpus 10 papers cited in narrative 10 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TGM1 encodes transglutaminase 1, a calcium-dependent crosslinking enzyme whose activity is concentrated in the differentiating layers of stratified squamous epithelia, where it forms the cornified cell envelope essential for skin barrier function (PMID:20876521). Loss of TGase-1 activity through point, frameshift, and splice mutations abolishes or markedly reduces enzymatic crosslinking and produces absent or incomplete cornified envelopes not only in epidermis but also in nail and hair cuticle cells, causing autosomal recessive congenital ichthyosis (PMID:9359043, PMID:11251583, PMID:16133457). Mutations cluster in functionally critical regions—the core domain, the beta-barrel 2 domain, and arginine residues positioned at domain interfaces—where they compromise structural integrity and catalytic function (PMID:11251583, PMID:19241467), and missense changes at R307/R315 confer temperature-sensitive phenotypes consistent with residual activity at cooler skin surface temperatures (PMID:22801880). Cell-layer- and tissue-specific expression of TGM1 is governed by a distal promoter region containing cooperative AP1 and Sp1 binding sites, whose combined mutation eliminates nearly all transcriptional activity (PMID:15061870). Post-translationally, TGase-1 is palmitoylated by the acyltransferase ZDHHC13, a modification required for its protein stability and for normal skin barrier development (PMID:31669413). Pathogenic TGM1 alleles are correctable by adenine base editing as a proof-of-concept therapeutic strategy (PMID:33974999).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1997 Medium

    Established that distinct classes of TGM1 mutation cause ichthyosis through separable mechanisms—transcriptional loss versus protein instability—both converging on loss of enzymatic activity.

    Evidence Northern blot, immunoblot, in situ TGase activity assay, and sequencing of patient alleles (Sp1-site promoter mutation; Gly143Glu, Val382Met missense)

    PMID:9359043

    Open questions at the time
    • Does not resolve the structural basis of protein instability for the missense alleles
    • No reconstitution of crosslinking activity in vitro
  2. 2001 Medium

    Mapped function to specific protein regions by showing that both the beta-barrel 2 and core domains are required for TGase-1 activity and complete cornified envelope formation.

    Evidence In situ TGase activity assay and electron microscopy of a patient bearing a beta-barrel 2 frameshift and core-domain R388H missense mutation

    PMID:11251583

    Open questions at the time
    • Single patient; contribution of each allele not separated
    • No direct structural measurement of domain perturbation
  3. 2004 High

    Defined the cis-regulatory logic of TGM1 expression, showing that cooperative AP1 and Sp1 sites in a distal promoter region drive tissue- and cell-layer-specific transcription.

    Evidence Transgenic mouse reporter assays, promoter deletion/mutation transfection in keratinocytes, and EMSA

    PMID:15061870

    Open questions at the time
    • Specific AP1/Sp1 family members binding in vivo not identified
    • Upstream signals regulating these factors during differentiation unknown
  4. 2005 Medium

    Extended the functional requirement for TGase-1 crosslinking beyond epidermis to nail and hair cuticle, broadening the affected-tissue scope of TGM1 deficiency.

    Evidence SDS/DTT extraction with phase contrast and electron microscopy of scale, nail, and hair from genotyped patients (V518M plus inactive allele)

    PMID:16133457

    Open questions at the time
    • Quantitative contribution of TGase-1 versus other transglutaminases in each appendage not parsed
  5. 2009 Low

    Proposed a unifying structural explanation for many pathogenic alleles by positioning mutated arginines at domain interfaces critical for TGase-1 integrity, and quantified founder alleles.

    Evidence Homology structural modeling across 115 mutations from 234 ARCI patients plus haplotype analysis (c.877-2A>G founder effect)

    PMID:19241467

    Open questions at the time
    • Structural inference is computational only with no experimental structure
    • Interface disruption not validated biochemically
  6. 2011 Medium

    Provided an isozyme-specific in situ readout that localized active TGase-1 to defined epithelial tissues, separating its activity from TGase-2 in vivo.

    Evidence Fluorescence-labeled isozyme-specific 12-mer substrate peptides applied to whole-body mouse sections

    PMID:20876521

    Open questions at the time
    • Substrate-peptide reporter reflects accessible activity, not endogenous physiological substrates
    • Does not identify in vivo crosslinked target proteins
  7. 2011 Low

    Linked environmental dioxin exposure to altered TGM1 expression by showing expansion of TGase-1-positive epidermal layers in chloracne lesions.

    Evidence FISH for mRNA and immunohistochemistry for protein in chloracne versus healthy skin

    PMID:21237254

    Open questions at the time
    • Descriptive only; no mechanism linking dioxin signaling to TGM1 regulation
    • No functional consequence for barrier established
  8. 2012 Low

    Connected residue-level genotype to temperature-dependent phenotype, implicating R307/R315 in thermolabile TGase-1 activity that explains site- and temperature-restricted disease.

    Evidence Genotype-phenotype correlation in 9 patients with bathing suit and self-improving collodion ichthyosis

    PMID:22801880

    Open questions at the time
    • No direct biochemical assay of temperature-dependent activity for these mutants
    • Thermolability mechanism inferred clinically only
  9. 2019 High

    Identified a post-translational control point by establishing ZDHHC13-mediated palmitoylation as required for TGase-1 protein stability and skin barrier integrity.

    Evidence Quantitative palmitoylation proteomics, biochemical palmitoylation confirmation, and an enzymatically dead ZDHHC13 knock-in mouse

    PMID:31669413

    Open questions at the time
    • Palmitoylated cysteine residue(s) on TGase-1 not mapped
    • Mechanism linking palmitoylation to stability (trafficking, degradation) unresolved
  10. 2021 Medium

    Demonstrated therapeutic correctability of a pathogenic TGM1 allele, establishing base editing as a feasible strategy for restoring the locus.

    Evidence Adenine base editing (ABEmax-NG, Sc-ABEmax) of c.607C>T in zygotes with whole-genome and deep sequencing for off-target analysis

    PMID:33974999

    Open questions at the time
    • No demonstration of restored TGase-1 activity or barrier function after editing
    • Delivery to differentiated epidermis not addressed

Open questions

Synthesis pass · forward-looking unresolved questions
  • The endogenous physiological substrates crosslinked by TGase-1 in the cornified envelope and the molecular mechanism linking palmitoylation to its stability remain undefined.
  • No experimental crystal/cryo-EM structure to validate domain-interface model
  • In vivo crosslinked target proteins unidentified
  • Palmitoylation site and stability mechanism unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 3 GO:0016740 transferase activity 2
Localization
GO:0005886 plasma membrane 1
Pathway
R-HSA-1643685 Disease 3 R-HSA-1266738 Developmental Biology 2
Partners
ZDHHC13

Evidence

Reading pass · 10 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 Three novel point mutations in the TGM1 (TGK) gene cause lamellar ichthyosis: a promoter Sp1-site mutation that profoundly reduces TGK transcript levels (impairing transcription), and two missense mutations (Gly143Glu, Val382Met) that produce normal transcript levels but lead to absence of detectable TGK protein, suggesting structural instability. All three mutations result in drastically reduced transglutaminase 1 enzymatic activity as measured by in situ activity assay. Northern blot (transcript quantification), immunofluorescence and immunoblotting (protein detection), transglutaminase activity assay, DNA sequencing of exons and exon-intron borders European journal of human genetics : EJHG Medium 9359043
2001 Novel TGM1 mutations in a patient with non-bullous congenital ichthyosiform erythroderma: a frameshift mutation (9008delA) in the beta-barrel 2 domain (C-terminal) and a missense mutation R388H in the core domain. In situ TGase activity assay showed markedly reduced TGase 1 activity in the patient's epidermis. Electron microscopy revealed incomplete thickening of the cornified cell envelope during keratinization, establishing that both the beta-barrel 2 domain and core domain are required for normal TGase-1 function and cornified envelope formation. In situ TGase activity assay, electron microscopy, DNA sequencing of TGM1 exons and exon-intron borders The British journal of dermatology Medium 11251583
2004 A distal region of the TGM1 promoter (between -1.6 and -1.4 kb) containing AP1 and Sp1 binding sites is required for tissue-specific and cell-layer-specific expression of TGM1 in transgenic mice and cultured keratinocytes. Mutation of both Sp1 sites and the AP1 site together eliminated nearly all transcriptional activity, while single mutations had only small effects. The same distal region also drives expression in squamous metaplasia under vitamin A deprivation. Transgenic mouse reporter assay, EMSA (electrophoretic mobility shift assay), promoter deletion and mutation transfection assays in cultured keratinocytes, Western blotting and immunohistochemistry BMC dermatology High 15061870
2005 Defective TGM1-encoded transglutaminase 1 activity results in absence or paucity of cornified cell envelopes (CEs) not only in epidermal scale but also in nail and hair cuticle cells. A V518M heterozygous TGM1 mutation combined with an inactive allele confers cross-linking deficiency across multiple keratinizing epithelia. Phase contrast microscopy and electron microscopy confirmed loss of prominent cell borders and marginal bands in hair cuticle cells from TGM1-deficient patients. SDS/DTT extraction of epidermal scale, nail, and hair; phase contrast microscopy; electron microscopy; clinical genotyping Archives of dermatological research Medium 16133457
2009 Structural modeling of human TGase-1 using 115 TGM1 mutations from 234 ARCI patients revealed that all mutated arginine residues located in the two beta-barrel domains and two (R142, R143) in the beta-sandwich domain reside at domain interfaces, suggesting these positions are critical for maintaining proper domain-domain interactions necessary for TGase-1 structural integrity and function. The c.877-2A>G splice-site mutation accounts for 34% of all TGM1 mutant alleles, with founder effects in North American and Norwegian populations. Homology structural modeling of TGase-1; mutational analysis across 234 patients; haplotype analysis for founder effect Human mutation Low 19241467
2011 Fluorescence-labeled isozyme-specific 12-amino acid substrate peptides enable rapid in situ detection of active TGase 1 (keratinocyte type) and TGase 2 (tissue type) with clearly distinct tissue distribution patterns in whole-body mouse sections. TGase 1 activity is strongly detected in epithelial tissues including tongue, developing teeth, forestomach, and skin epidermis, establishing the spatial pattern of active TGase 1 protein in vivo. In situ detection using fluorescence-labeled isozyme-specific substrate peptides; whole-body section analysis The journal of histochemistry and cytochemistry Medium 20876521
2012 Specific TGM1 missense mutations affecting arginine at positions 307 or 315 are associated with temperature-sensitive phenotypes (bathing suit ichthyosis and self-improving collodion ichthyosis), suggesting that these arginine residues are critical for temperature-dependent TGase-1 activity, with the protein retaining partial function at cooler body surface temperatures but losing function at warmer core body temperature sites. Genotype-phenotype correlation in 9 patients; clinical phenotypic assessment; DNA sequencing identifying missense mutations Archives of dermatology Low 22801880
2019 The palmitoyl-acyl transferase ZDHHC13 palmitoylates TGM1 (transglutaminase 1), and this palmitoylation is critical for in vivo protein stability of TGase-1. Quantitative proteomic approaches identified TGM1 as a ZDHHC13 substrate, and biochemical assay confirmed palmitoylation. Loss of ZDHHC13 enzymatic activity (knock-in DQ-to-AA mutation) led to skin barrier defects and loss of TGase-1 stability, establishing palmitoylation as a post-translational modification required for TGase-1 function in skin barrier development. Quantitative proteomics to identify palmitoylation substrates; biochemical palmitoylation assay confirmation; knock-in mouse model with enzymatically dead ZDHHC13; protein stability assessment The Journal of investigative dermatology High 31669413
2021 The pathogenic TGM1 mutation c.607C>T can be corrected in mutant zygotes by adenine base editing (ABE). Using ABEmax-NG with 20-bp sgRNA achieved 73.8% editing efficiency, and Sc-ABEmax with 19-bp sgRNA achieved 78.7% efficiency. Whole-genome sequencing confirmed precise DNA editing without detected off-target effects, establishing proof-of-concept for base-editing correction of TGM1 mutations. Adenine base editing (ABEmax-NG, Sc-ABEmax) in zygotes; whole-genome sequencing; deep sequencing for off-target analysis Molecular therapy : the journal of the American Society of Gene Therapy Medium 33974999
2011 Abnormal expression of TGk (TGM1/transglutaminase 1) is detected in chloracne skin lesions from dioxin-exposed patients: TGk mRNA and protein positive signals, normally restricted to the stratum granulosum, were found more significantly distributed in both the stratum granulosum and stratum spinosum in chloracne tissues, suggesting dioxin exposure expands the epidermal layer expressing TGase-1. Fluorescence in situ hybridization (FISH) for mRNA; immunohistochemistry for protein; comparison with healthy controls Toxicology letters Low 21237254

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 Li-fraumeni syndrome. Genes & cancer 313 21779515
2023 Visualizing interfacial collective reaction behaviour of Li-S batteries. Nature 196 37673990
2016 Li7La3Zr2O12 Interface Modification for Li Dendrite Prevention. ACS applied materials & interfaces 165 27029789
2006 The TP53 mutation, R337H, is associated with Li-Fraumeni and Li-Fraumeni-like syndromes in Brazilian families. Cancer letters 159 16494995
1993 p53 and the Li-Fraumeni syndrome. Cancer genetics and cytogenetics 137 8500106
2022 Carbon-free and binder-free Li-Al alloy anode enabling an all-solid-state Li-S battery with high energy and stability. Science advances 96 35417237
2020 Fast Li+ Conduction Mechanism and Interfacial Chemistry of a NASICON/Polymer Composite Electrolyte. Journal of the American Chemical Society 92 31927889
1998 Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni like family members. Oncogene 92 9704930
2009 Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: summary of mutations (including 23 novel) and modeling of TGase-1. Human mutation 77 19241467
2009 Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients. The Journal of investigative dermatology 72 19890349
2020 Double-crosslinked effect of TGase and EGCG on myofibrillar proteins gel based on physicochemical properties and molecular docking. Food chemistry 70 33302098
2022 Suppressing electrolyte-lithium metal reactivity via Li+-desolvation in uniform nano-porous separator. Nature communications 65 35013293
2019 Hematologic malignancies and Li-Fraumeni syndrome. Cold Spring Harbor molecular case studies 64 30709875
2024 High-Entropy MXene as Bifunctional Mediator toward Advanced Li-S Full Batteries. ACS nano 60 38194614
2025 External Li supply reshapes Li deficiency and lifetime limit of batteries. Nature 58 39939772
2016 Li-Fraumeni Syndrome. Journal of pediatric genetics 57 27617148
2020 In Situ Designing a Gradient Li+ Capture and Quasi-Spontaneous Diffusion Anode Protection Layer toward Long-Life Li-O2 Batteries. Advanced materials (Deerfield Beach, Fla.) 53 32776397
2002 The Li-Fraumeni syndrome. Biochimie 53 11900879
2001 Analysis of epidermal-type transglutaminase (TGase 3) expression in mouse tissues and cell lines. The international journal of biochemistry & cell biology 50 11331204
2010 Silver-Russell patients showing a broad range of ICR1 and ICR2 hypomethylation in different tissues. Clinical genetics 49 20738330
2012 Epidermal transglutaminase (TGase 3) is required for proper hair development, but not the formation of the epidermal barrier. PloS one 44 22496784
1990 Point mutations in the ICR2 motif of brome mosaic virus RNAs debilitate (+)-strand replication. Virology 39 2389549
2013 IgE production in CD40/CD40L cross-talk of B and mast cells and mediator release via TGase 2 in mouse allergic asthma. Cellular signalling 37 23524335
2013 Li-Fraumeni and Li-Fraumeni-like syndrome among children diagnosed with pediatric cancer in Southern Brazil. Cancer 37 24122735
2011 In situ detection of active transglutaminases for keratinocyte type (TGase 1) and tissue type (TGase 2) using fluorescence-labeled highly reactive substrate peptides. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 37 20876521
1997 Retinoic acid and IFN inhibition of cell proliferation is associated with apoptosis in squamous carcinoma cell lines: role of IRF-1 and TGase II-dependent pathways. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 37 8993838
2011 Microduplication of the ICR2 domain at chromosome 11p15 and familial Silver-Russell syndrome. American journal of medical genetics. Part A 36 21910219
2024 Sulfonic Acid-Functionalized Graphdiyne for Effective Li-S Battery Separators. Journal of the American Chemical Society 35 39149921
2023 Weakening Li+ De-solvation Barrier for Cryogenic Li-S Pouch Cells. Advanced materials (Deerfield Beach, Fla.) 35 36583421
2017 A Gly65Val substitution in an actin, GhACT_LI1, disrupts cell polarity and F-actin organization resulting in dwarf, lintless cotton plants. The Plant journal : for cell and molecular biology 34 28078746
2021 Stamping Flexible Li Alloy Anodes. Advanced materials (Deerfield Beach, Fla.) 33 33569846
2018 Revealing the Rate-Limiting Li-Ion Diffusion Pathway in Ultrathick Electrodes for Li-Ion Batteries. The journal of physical chemistry letters 33 30130117
2019 Li-Fraumeni syndrome heterogeneity. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 30 31691207
2013 Transcript profiling by microarray and marker analysis of the short cotton (Gossypium hirsutum L.) fiber mutant Ligon lintless-1 (Li1). BMC genomics 30 23767687
2008 The prostate transglutaminase (TGase-4, TGaseP) regulates the interaction of prostate cancer and vascular endothelial cells, a potential role for the ROCK pathway. Microvascular research 30 18983858
2022 High performance Li-, Na-, and K-ion storage in electrically conducting coordination polymers. Energy & environmental science 29 36275406
2022 Modification of fermented whey protein concentrates: Impact of sequential ultrasound and TGase cross-linking. Food research international (Ottawa, Ont.) 29 36596109
2001 Novel mutations of TGM1 in a child with congenital ichthyosiform erythroderma. The British journal of dermatology 29 11251583
1997 Three novel point mutations in the keratinocyte transglutaminase (TGK) gene in lamellar ichthyosis: significance for mutant transcript level, TGK immunodetection and activity. European journal of human genetics : EJHG 29 9359043
2023 Solid-Solution or Intermetallic Compounds: Phase Dependence of the Li-Alloying Reactions for Li-Metal Batteries. Journal of the American Chemical Society 25 37909780
2017 Polymer-Rich Composite Electrolytes for All-Solid-State Li-S Cells. The journal of physical chemistry letters 25 28696704
2018 Competition between Li+ and Na+ in sodium transporters and receptors: Which Na+-Binding sites are "therapeutic" Li+ targets? Chemical science 22 29780538
2018 Elastic and Li-ion-percolating hybrid membrane stabilizes Li metal plating. Proceedings of the National Academy of Sciences of the United States of America 22 30455289
2003 TP53, hChk2, and the Li-Fraumeni syndrome. Methods in molecular biology (Clifton, N.J.) 22 12710683
2019 Palmitoyl Acyltransferase Activity of ZDHHC13 Regulates Skin Barrier Development Partly by Controlling PADi3 and TGM1 Protein Stability. The Journal of investigative dermatology 21 31669413
2015 Transcriptome Analysis of Short Fiber Mutant Ligon lintless-1 (Li1) Reveals Critical Genes and Key Pathways in Cotton Fiber Elongation and Leaf Development. PloS one 21 26600249
2012 Specific TGM1 mutation profiles in bathing suit and self-improving collodion ichthyoses: phenotypic and genotypic data from 9 patients with dynamic phenotypes of autosomal recessive congenital ichthyosis. Archives of dermatology 20 22801880
2007 Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer. Journal of experimental therapeutics & oncology 20 17552366
2023 CD44 acts as a coreceptor for cell-specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimic. Proceedings of the National Academy of Sciences of the United States of America 19 37590410
2019 Lithium ions (Li+) and nanohydroxyapatite (nHAp) doped with Li+ enhance expression of late osteogenic markers in adipose-derived stem cells. Potential theranostic application of nHAp doped with Li+ and co-doped with europium (III) and samarium (III) ions. Materials science & engineering. C, Materials for biological applications 19 30889661
2018 Patients with congenital ichthyosis and TGM1 mutations overexpress other ARCI genes in the skin: Part of a barrier repair response? Experimental dermatology 18 30372788
2015 Pediatric cancer and Li-Fraumeni/Li-Fraumeni-like syndromes: a review for the pediatrician. Revista da Associacao Medica Brasileira (1992) 18 26248253
2021 Lattice-Oxygen-Stabilized Li- and Mn-Rich Cathodes with Sub-Micrometer Particles by Modifying the Excess-Li Distribution. Advanced materials (Deerfield Beach, Fla.) 17 33783055
2017 Pathology-targeted cell delivery via injectable micro-scaffold capsule mediated by endogenous TGase. Biomaterials 17 28237907
2005 Structural changes in epidermal scale and appendages as indicators of defective TGM1 activity. Archives of dermatological research 17 16133457
2022 Soybean protein isolate treated with transglutaminase (TGase) enhances the heat tolerance of selected lactic acid bacteria strains to spray drying. Food chemistry 16 36283314
2012 Multiple local and recent founder effects of TGM1 in Spanish families. PloS one 16 22511925
2011 Li+ ionic conductivities and diffusion mechanisms in Li-based imides and lithium amide. Physical chemistry chemical physics : PCCP 16 22173712
2010 The prostate transglutaminase, TGase-4, coordinates with the HGFL/MSP-RON system in stimulating the migration of prostate cancer cells. International journal of oncology 16 20596668
2004 A distal region of the human TGM1 promoter is required for expression in transgenic mice and cultured keratinocytes. BMC dermatology 16 15061870
2023 Weak-Coordination Electrolyte Enabling Fast Li+ Transport in Lithium Metal Batteries at Ultra-Low Temperature. Small (Weinheim an der Bergstrasse, Germany) 15 36890773
2013 Prostate transglutaminase (TGase-4, TGaseP) enhances the adhesion of prostate cancer cells to extracellular matrix, the potential role of TGase-core domain. Journal of translational medicine 15 24161123
2024 Fabrication and characterization of novel TGase-mediated glycosylated whey protein isolate nanoparticles for curcumin delivery. Food chemistry 14 39182336
2021 Different Thermal Treatment Methods and TGase Addition Affect Gel Quality and Flavour Characteristics of Decapterus maruadsi Surimi Products. Foods (Basel, Switzerland) 14 35010193
2018 Self-Assembled Protein Nanofilter for Trapping Polysulfides and Promoting Li+ Transport in Lithium-Sulfur Batteries. The journal of physical chemistry letters 14 29688730
2009 Familial gastric cancer and Li-Fraumeni syndrome. European journal of cancer care 14 19674071
2001 Li24[MnN3]3N2 and Li5[(Li1-xMnx)N]3, two intermediates in the decomposition path of Li7[MnN4] to Li2[(Li1-xMnx)N]: an experimental and theoretical study. Inorganic chemistry 14 11559085
2021 Correction of the pathogenic mutation in TGM1 gene by adenine base editing in mutant embryos. Molecular therapy : the journal of the American Society of Gene Therapy 13 33974999
2017 Prostate Transglutaminase (TGase-4) Induces Epithelial-to-Mesenchymal Transition in Prostate Cancer Cells. Anticancer research 13 28179293
2022 One-Dimensional Porous Li-Confinable Hosts for High-Rate and Stable Li-Metal Batteries. ACS nano 12 35737978
2020 TGase-mediated cell membrane modification and targeted cell delivery to inflammatory endothelium. Biomaterials 12 32797997
2019 Disruption of KCNQ1 prevents methylation of the ICR2 and supports the hypothesis that its transcription is necessary for imprint establishment. European journal of human genetics : EJHG 12 30778172
2018 Structure-dynamic and functional relationships in a Li+-transporting sodium‑calcium exchanger mutant. Biochimica et biophysica acta. Bioenergetics 12 30414928
2010 Knockdown of Li-cadherin increases metastatic behaviors of LoVo cells. Journal of cancer research and clinical oncology 12 20204409
2024 Li2ZnCu3 Modified Cu Current Collector to Regulate Li Deposition. Angewandte Chemie (International ed. in English) 11 39275906
2020 TGase-Enhanced Microtissue Assembly in 3D-Printed-Template-Scaffold (3D-MAPS) for Large Tissue Defect Reparation. Advanced healthcare materials 11 32803857
2014 Perception, signaling and cross-talk of jasmonates and the seminal contributions of the Daoxin Xie's lab and the Chuanyou Li's lab. Plant cell reports 11 24691578
2012 Congenital lamellar ichthyosis in Tunisia is caused by a founder nonsense mutation in the TGM1 gene. Molecular biology reports 11 23192619
1999 Analysis of Li-Fraumeni syndrome and Li-Fraumeni-like families for germline mutations in Bcl10. Cancer letters 11 10660104
2017 TP53 and CDKN1A mutation analysis in families with Li-Fraumeni and Li-Fraumeni like syndromes. Familial cancer 10 27714481
2011 Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer. Journal of translational medicine 10 21524313
2024 Synthesis and Characterization of Lithium Pyrocarbonate (Li2[C2O5]) and Lithium Hydrogen Pyrocarbonate (Li[HC2O5]). Angewandte Chemie (International ed. in English) 9 39503066
2024 Effects of TGase on the rheological behaviors, structural properties and molecular forces of cowpea protein isolate and cowpea albumin gels. International journal of biological macromolecules 9 39730059
2022 Ion sieve membrane: Homogenizing Li+ flux and restricting polysulfides migration enables long life and highly stable Li-S battery. Journal of colloid and interface science 9 35878463
2020 High prevalence of autosomal recessive congenital ichthyosis in a Mexican population caused by a new mutation in the TGM1 gene: epidemiological evidence of a founder effect. International journal of dermatology 9 32436339
2015 Genetic fine mapping and candidate gene analysis of the Gossypium hirsutum Ligon lintless-1 (Li1) mutant on chromosome 22(D). Molecular genetics and genomics : MGG 9 26037218
2014 Organic-acid-assisted fabrication of low-cost Li-rich cathode material (Li[Li1/6Fe1/6Ni1/6Mn1/2]O2) for lithium-ion battery. ACS applied materials & interfaces 9 25412470
2003 Effects of Li(+) transport and Li(+) immobilization on Li(+)/Mg(2+) competition in cells: implications for bipolar disorder. Biochemical pharmacology 9 14599549
2024 Tailoring Li Deposition by Regulating Structural Connectivity of Electrochemical Li Reservoir in Li-metal Batteries. Angewandte Chemie (International ed. in English) 8 38195861
2024 Li-Fraumeni-associated osteosarcomas: The French experience. Pediatric blood & cancer 8 39387369
2021 Li3La2(BO3)3 and Li1.75Na1.25La2(BO3)3: A Great Enhancement in Birefringence Induced by Optimal Arrangement of π-Conjugated [BO3] Units. Inorganic chemistry 8 34328321
2016 Novel mutations in TGM1 and ABCA12 cause autosomal recessive congenital ichthyosis in five Saudi families. International journal of dermatology 8 27061915
2015 Novel mutations in the genes TGM1 and ALOXE3 underlying autosomal recessive congenital ichthyosis. International journal of dermatology 8 26578203
2014 mRNA Transcript abundance during plant growth and the influence of Li(+) exposure. Plant science : an international journal of experimental plant biology 8 25443852
1997 [Li-Fraumeni syndrome]. Bulletin du cancer 8 9339200
2024 A pan-cancer analysis of the oncogenic and immunological roles of transglutaminase 1 (TGM1) in human cancer. Journal of cancer research and clinical oncology 7 38472489
2016 Li-Fraumeni syndrome. Biomedica : revista del Instituto Nacional de Salud 7 27622479
2011 Abnormal expression of MAPK, EGFR, CK17 and TGk in the skin lesions of chloracne patients exposed to dioxins. Toxicology letters 7 21237254
2008 p53 Testing for Li-Fraumeni and Li-Fraumeni-like syndromes. Current protocols in human genetics 7 18428420
1998 Glutathione transferase (class pi) and tissue transglutaminase (Tgase C) expression in pterygia. Korean journal of ophthalmology : KJO 7 9753945

Missed literature

Know a paper Affinage missed for TGM1? Flag it for the maintainers and the community.

No submissions yet.