Affinage

TECTA

Alpha-tectorin · UniProt O75443

Length
2155 aa
Mass
239.5 kDa
Annotated
2026-06-10
58 papers in source corpus 15 papers cited in narrative 15 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TECTA encodes alpha-tectorin, the major non-collagenous glycoprotein of the cochlear tectorial membrane (TM), where it builds the striated-sheet matrix required for normal hearing (PMID:18452040, PMID:21575588). Within the TM, alpha-tectorin interacts with beta-tectorin and otogelin, and a recessive A349D substitution that is incorporated into the TM yet cannot bind these partners abolishes striated-sheet assembly and depletes beta-tectorin and otogelin, identifying them as functional partners in matrix construction (PMID:18452040). Tecta is transcribed at high levels during TM morphogenesis, peaking at postnatal day 3 (PMID:11711860). Functionally, TECTA-dependent TM attachment mechanically couples sound-induced vibration to outer hair cell mechanotransduction: detachment of the TM abolishes normal TM-dependent hair cell excitation and otoacoustic emissions (PMID:14523068), and point mutations that alter TM composition reduce fixed charge, raise porosity, lower shear impedance and axial stiffness, and degrade OHC stereociliary coupling and amplification (PMID:21081075, PMID:21575588, PMID:30627650). Mutations show domain-specific genotype-phenotype relationships, with knock-in alleles in distinct domains producing characteristic threshold and structural phenotypes (PMID:24363064), and dominant disease alleles act through a dominant-negative mechanism rather than haploinsufficiency, since splicing variants produce altered protein without reducing mRNA levels (PMID:38676628, PMID:40583560).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1998 Medium

    Establishing the genomic location of TECTA was needed to test whether this TM glycoprotein underlies an inherited deafness locus.

    Evidence YAC-based physical mapping and mouse-human synteny analysis placing TECTA in the DFNA12 candidate interval

    PMID:9503015

    Open questions at the time
    • Mapping alone does not prove causation
    • No functional consequence of any allele established
  2. 1999 Medium

    A recessive splice-site mutation showed TECTA loss can cause deafness and implied alpha-tectorin functions in homo- or heteromeric assemblies.

    Evidence Linkage and gene sequencing in a consanguineous family with carrier-versus-dominant phenotype comparison

    PMID:9949200

    Open questions at the time
    • Protein truncation inferred, not directly observed
    • Oligomeric partners not identified at this stage
  3. 2001 Medium

    Defining when TECTA is expressed clarified its developmental window of action in TM formation.

    Evidence Quantitative RT-PCR across mouse cochlear developmental time points

    PMID:11711860

    Open questions at the time
    • mRNA timing does not establish protein dynamics
    • No link to specific assembly events
  4. 2003 High

    Whether TM attachment is required for hair cell function was tested by examining a TM-detached mutant, showing the TM mechanically couples sound to OHC excitation.

    Evidence DPOAE recording in Tecta(deltaENT/deltaENT) mice with detached TMs

    PMID:14523068

    Open questions at the time
    • Does not resolve which molecular interactions mediate attachment
    • Mechanism distinct from frank TM absence not dissected
  5. 2004 Low

    Cross-family correlation linked vWFD-domain cysteine mutations to high-frequency loss versus mid-frequency loss for other mutations, introducing domain-specific genotype-phenotype mapping.

    Evidence TECTA sequencing and linkage across three families with conserved cysteine substitutions

    PMID:15319541

    Open questions at the time
    • No direct biochemical validation of proposed disulfide bonds or interactions
    • Clinical correlation only, no functional assay
  6. 2008 High

    Identifying alpha-tectorin's TM binding partners answered how the matrix is assembled: the A349D protein incorporates but fails to bind beta-tectorin and otogelin, abolishing the striated-sheet matrix.

    Evidence Spontaneous mouse missense mutant with immunolabeling for Tectb and otogelin and EM of TM ultrastructure

    PMID:18452040

    Open questions at the time
    • Direct biochemical interaction surfaces not mapped
    • Stoichiometry of the matrix network unresolved
  7. 2008 Medium

    A synonymous variant disrupting an exonic splice enhancer showed that splicing defects deleting sequence near the ZP domain impair alpha-tectorin function.

    Evidence RT-PCR of aberrant transcript, ESE prediction, and segregation analysis

    PMID:18575463

    Open questions at the time
    • Effect on protein folding/secretion inferred, not measured
    • Mechanism of ZP-domain impairment not shown directly
  8. 2010 High

    How a dominant mutation degrades hearing was answered biophysically: Y1870C lowers tectorin and glycoconjugate content, fixed charge, and shear impedance, tying TM material properties to threshold shifts.

    Evidence Force spectroscopy, osmotic pressure and fixed-charge measurement, and lectin/immunolabeling in Tecta(Y1870C/+) TMs

    PMID:21081075

    Open questions at the time
    • Molecular basis of porosity increase not resolved at structural level
    • Heterozygous protein interaction defect not directly visualized
  9. 2011 High

    The C1509G allele linked alpha-tectorin directly to OHC mechanical coupling, showing dose-dependent loss of TM-OHC attachment and reduced TM stiffness that lowers stereociliary deflection.

    Evidence SHG/THG imaging, SEM, stereocilin immunolabeling, force spectroscopy, and modeling across genotypes

    PMID:21575588

    Open questions at the time
    • Molecular interface between TM and stereocilin/stereocilia not defined
    • Causal link from stiffness to amplification is model-based
  10. 2011 Medium

    A splice-site variant producing a truncated protein in compound heterozygosity confirmed recessive nonsyndromic hearing loss from TECTA disruption.

    Evidence In vitro exon-trapping assay and Sanger sequencing with segregation analysis

    PMID:22037481

    Open questions at the time
    • Truncated protein not characterized at protein level
    • TM consequences not examined
  11. 2012 Medium

    Why ZP-domain missense mutations are pathogenic was addressed by showing they alter intracellular localization, implicating impaired secretion and reduced TM incorporation.

    Evidence In vitro expression and localization comparison of wild-type versus mutant alpha-tectorin

    PMID:22718023

    Open questions at the time
    • Single cell-based localization assay without reconstitution or structural validation
    • Secretion defect inferred from localization only
  12. 2013 High

    An allelic series of knock-in mice established that ZP- versus ZA-domain mutations produce distinct TM structural and threshold phenotypes, formalizing domain-specific pathology.

    Evidence Three knock-in mouse models with ABR thresholds and TM structural analysis

    PMID:24363064

    Open questions at the time
    • Molecular mechanism distinguishing domain effects not fully resolved
    • Frequency mapping to TM regions not mechanistically dissected
  13. 2018 Medium

    How a structural TM defect alters cochlear amplification was probed by showing Y1870C/+ mice over-emit SOAEs with separated Kimura's membrane, indicating dysregulated OHC amplification control.

    Evidence SOAE recording, suppressor-tone experiments, and TM structural analysis in knock-in mice

    PMID:30627650

    Open questions at the time
    • Causal chain from TM separation to SOAE emission not fully mechanistic
    • Single lab
  14. 2025 Medium

    Whether dominant splicing variants act by loss of dosage or dominant-negative effect was resolved: aberrant splicing alters protein without reducing mRNA, supporting a dominant-negative mechanism for DFNA8/12.

    Evidence Minigene and in vivo RNA analysis with qRT-PCR for two splice variants (c.5383+6T>A and c.5999G>A)

    PMID:38676628 PMID:40583560

    Open questions at the time
    • Direct demonstration of mutant protein poisoning wild-type assembly not shown
    • Effect on TM not examined in patient tissue

Open questions

Synthesis pass · forward-looking unresolved questions
  • The atomic-level interaction surfaces by which alpha-tectorin binds beta-tectorin, otogelin, and the OHC stereociliary apparatus, and the molecular basis of dominant-negative interference, remain undefined.
  • No structural model of the alpha-tectorin matrix network
  • Disulfide bonding and ZP-domain processing not biochemically resolved
  • Mechanism of dominant-negative protein interaction not directly demonstrated

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 2
Localization
GO:0031012 extracellular matrix 3
Pathway
R-HSA-9709957 Sensory Perception 2 R-HSA-1474244 Extracellular matrix organization 1
Partners
OTOGSTRCTECTB
Complex memberships
tectorial membrane striated-sheet matrix

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 A splice-site mutation in TECTA (GT donor site of intron 9) predicts a truncated alpha-tectorin protein of 971 amino acids and causes autosomal recessive deafness (DFNB21), establishing that TECTA mutations can cause both dominant and recessive deafness and providing genetic evidence that alpha-tectorin forms homo- or heteromeric structures. Linkage analysis and TECTA gene sequencing in a consanguineous Lebanese family; comparison of heterozygous carrier phenotype with dominant DFNA8/12 phenotype Human molecular genetics Medium 9949200
1998 The TECTA gene encoding alpha-tectorin, a major noncollagenous component of the tectorial membrane, was mapped to human chromosome 11q and mouse chromosome 9, placing it within the DFNA12 candidate interval and consistent with a role in tectorial membrane structure required for hearing. Chromosomal mapping using YAC clones and physical linkage to marker D11S925; mouse-human synteny analysis Genomics Medium 9503015
2001 TECTA mRNA expression in mouse cochlea peaks at postnatal day 3 and dramatically decreases by P15, indicating TECTA is transcribed at particularly high levels during tectorial membrane morphogenesis. Quantitative non-radioactive RT-PCR across developmental time points (E15 through adulthood) in mouse cochlea Neuroreport Medium 11711860
2003 Tecta(deltaENT/deltaENT) mice with detached tectorial membranes (TM) show markedly reduced distortion product otoacoustic emissions only detectable above 65 dB SPL and loss of normal TM-dependent hair cell excitation, demonstrating that TECTA-dependent TM attachment is required for normal outer hair cell mechanotransduction via the TM. DPOAE recording in wild-type vs. Tecta(deltaENT/deltaENT) mutant mice with detached TMs; electrophysiological comparison Journal of neurophysiology High 14523068
2008 A missense mutation in the Tecta gene (c.1046C>A, p.A349D) in mouse is recessive and causes tectorial membrane (TM) detachment, loss of striated-sheet matrix, and deficiency of beta-tectorin and otogelin in the TM. Mutated Tecta (A349D) protein is incorporated into the TM but is unable to interact with beta-tectorin or otogelin, identifying these as functional binding partners of alpha-tectorin in TM assembly. Characterization of spontaneous mouse Tecta missense mutant; immunolabeling for Tecta, Tectb (beta-tectorin), and otogelin; electron microscopy of TM structure; comparison with Tecta(deltaENT/deltaENT) mouse Journal of the Association for Research in Otolaryngology : JARO High 18452040
2010 The Tecta(Y1870C/+) heterozygous missense mutation reduces tectorin content and glycoconjugate content of the tectorial membrane (TM), decreases fixed charge concentration, reduces osmotic pressure response, and decreases both radial and longitudinal TM shear impedance by ~10 dB, consistent with increased TM porosity; these mechanical changes underlie the 60-dB hearing threshold shift in these mice. Force spectroscopy, osmotic pressure response measurement, fixed charge concentration measurement, lectin/immunolabeling (wheat germ agglutinin) in TMs from Tecta(Y1870C/+) vs. wild-type mice Biophysical journal High 21081075
2011 The Tecta C1509G mutation causes altered collagen architecture and stereocilin-labeling patterns in the TM. Heterozygous TM attaches only to the first row of outer hair cells (OHCs) and homozygous TM does not attach to any OHCs. The axial Young's modulus of the mutant TM is significantly reduced in the basal region, and modeling shows this reduces OHC stereociliary deflection, mechanistically linking alpha-tectorin to TM mechanical coupling with OHC stereocilia. Second- and third-harmonic imaging, scanning electron microscopy, immunolabeling (stereocilin), force spectroscopy with Young's modulus measurements, and mechanical modeling in wild-type, heterozygous, and homozygous Tecta C1509G mice Biophysical journal High 21575588
2012 ZP-domain missense mutations in TECTA affect intracellular localization of alpha-tectorin in vitro, suggesting that these mutations impair protein secretion and reduce incorporation of alpha-tectorin into the tectorial membrane. In vitro expression of wild-type and mutant alpha-tectorin; comparison of intracellular localization patterns between wild-type and missense mutants Journal of human genetics Medium 22718023
2013 ZP-domain mutations in Tecta (L1820F/G1824D and C1837G) cause distinct structural TM changes including elevated auditory thresholds of 30–40 dB in 8–40 kHz range, while a ZA-domain mutation (C1619S) elevates thresholds by 20–30 dB, establishing domain-specific structural phenotypes in the TM and an allelic series linking genotype to phenotype and TM structural changes. Creation and characterization of three knock-in mouse models; auditory brainstem response (ABR) threshold measurements; structural analysis of TM in domain-specific mutants Human molecular genetics High 24363064
2008 A synonymous TECTA mutation (c.5331G>A; p.L1777L) causes loss of an exonic splice enhancer (ESE), leading to aberrant exon 16 skipping and an in-frame deletion of 37 amino acids (p.S1758Y/G1759_N1795del) in alpha-tectorin just N-terminal of the ZP domain, demonstrating that the protein deletion likely impairs ZP domain processing and function. RT-PCR of aberrant TECTA transcript from affected individual; splice enhancer prediction; segregation analysis European journal of human genetics : EJHG Medium 18575463
2011 A splice site mutation (c.6162+3insT) in TECTA causes exon skipping leading to a truncated protein, as demonstrated by exon-trapping analysis in vitro; compound heterozygous mutations (p.C1691F missense + splice mutation) in TECTA cause recessive nonsyndromic hearing loss. Exon-trapping in vitro functional assay for splice site mutation; Sanger sequencing for missense mutation; segregation analysis Gene Medium 22037481
2018 Tecta(Y1870C/+) heterozygous mice are prolific emitters of spontaneous otoacoustic emissions (SOAEs) despite moderate hearing loss, and Kimura's membrane separates from the main body of the TM except at apical locations. Second-harmonic SOAEs are present and are not spatially separated from their primaries, demonstrating that the alpha-tectorin Y1870C mutation disrupts TM structural integrity in a way that alters how OHC amplification is controlled by the TM. SOAE recording from ear canal in Tecta(Y1870C/+) knock-in mice; suppressor tone experiments; structural analysis of TM eNeuro Medium 30627650
2024 A novel splice-site variant c.5383+6T>A in TECTA causes aberrant splicing with exon 16 skipping, as confirmed by minigene-based splicing analysis and in vivo RNA analysis; quantitative RT-PCR shows no significant reduction in mRNA levels, indicating the dominant-negative effect rather than haploinsufficiency underlies DFNA8/12 in this family. Minigene splicing assay; in vivo RNA analysis from patient samples; quantitative RT-PCR; protein structure prediction by molecular modeling; whole-exome sequencing Human molecular genetics Medium 38676628
2025 A novel TECTA variant c.5999G>A (p.Gly2000Glu) causes aberrant splicing of exon 20, resulting in two in-frame deletions. Quantitative RT-PCR shows no significant reduction in mRNA levels in lymphoblasts from carriers, supporting a dominant-negative rather than haploinsufficiency mechanism for DFNA8/12 caused by splicing variants. In vivo RNA analysis; exome sequencing; qRT-PCR of lymphoblast-derived RNA; pedigree analysis in five-generation Chinese family Human molecular genetics Medium 40583560
2004 A cysteine-to-glycine substitution in the vWFD4 domain of alpha-tectorin (C1509G) causes progressive high-frequency hearing loss, while mutations outside the vWFD domains cause mid-frequency hearing impairment, establishing a domain-specific genotype-phenotype correlation; the vWFD domain cysteines are proposed to participate in disulfide bonds and protein-protein interactions critical for TM function. TECTA gene sequencing; linkage analysis (LOD 4.6); comparison across three families with conserved cysteine mutations in vWFD domain Cellular physiology and biochemistry Low 15319541

Source papers

Stage 0 corpus · 58 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1999 An alpha-tectorin gene defect causes a newly identified autosomal recessive form of sensorineural pre-lingual non-syndromic deafness, DFNB21. Human molecular genetics 136 9949200
2011 DFNA8/12 caused by TECTA mutations is the most identified subtype of nonsyndromic autosomal dominant hearing loss. Human mutation 71 21520338
1981 Anatomy and physiology of experimentally produced striped tecta. The Journal of neuroscience : the official journal of the Society for Neuroscience 67 6980968
1997 N-methyl-D-aspartate receptor activation and visual activity induce elongation factor-2 phosphorylation in amphibian tecta: a role for N-methyl-D-aspartate receptors in controlling protein synthesis. Proceedings of the National Academy of Sciences of the United States of America 58 9405688
1997 A gene for autosomal dominant nonsyndromic hearing loss (DFNA12) maps to chromosome 11q22-24. American journal of human genetics 50 9150164
2013 Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane. Human molecular genetics 47 24363064
2008 Aeromonas tecta sp. nov., isolated from clinical and environmental sources. Systematic and applied microbiology 44 18617346
2004 A genotype-phenotype correlation with gender-effect for hearing impairment caused by TECTA mutations. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 44 15319541
2006 A novel TECTA mutation in a Dutch DFNA8/12 family confirms genotype-phenotype correlation. Journal of the Association for Research in Otolaryngology : JARO 42 16718611
2007 Identification of three novel TECTA mutations in Iranian families with autosomal recessive nonsyndromic hearing impairment at the DFNB21 locus. American journal of medical genetics. Part A 41 17431902
2002 Association of clinical features with mutation of TECTA in a family with autosomal dominant hearing loss. Archives of otolaryngology--head & neck surgery 40 12162770
2007 A novel TECTA mutation confirms the recognizable phenotype among autosomal recessive hearing impairment families. International journal of pediatric otorhinolaryngology 39 18022253
2008 Mid-frequency DFNA8/12 hearing loss caused by a synonymous TECTA mutation that affects an exonic splice enhancer. European journal of human genetics : EJHG 37 18575463
1998 Autosomal-dominant, prelingual, nonprogressive sensorineural hearing loss: localization of the gene (DFNA8) to chromosome 11q by linkage in an Austrian family. Cytogenetics and cell genetics 33 9763681
1998 Mapping of the alpha-tectorin gene (TECTA) to mouse chromosome 9 and human chromosome 11: a candidate for human autosomal dominant nonsyndromic deafness. Genomics 32 9503015
1990 The directed growth of retinal axons towards surgically transposed tecta in Xenopus; an examination of homing behaviour by retinal ganglion cell axons. Development (Cambridge, England) 31 2351060
2019 The Prevalence and Clinical Characteristics of TECTA-Associated Autosomal Dominant Hearing Loss. Genes 30 31554319
2010 Two novel missense mutations in the TECTA gene in Korean families with autosomal dominant nonsyndromic hearing loss. Annals of clinical and laboratory science 30 20947814
1998 A new autosomal-dominant locus (DFNA12) is responsible for a nonsyndromic, midfrequency, prelingual and nonprogressive sensorineural hearing loss. The American journal of otology 28 9831143
2012 TECTA mutations in Japanese with mid-frequency hearing loss affected by zona pellucida domain protein secretion. Journal of human genetics 25 22718023
2003 Role of the tectorial membrane revealed by otoacoustic emissions recorded from wild-type and transgenic Tecta(deltaENT/deltaENT) mice. Journal of neurophysiology 25 14523068
2006 Audiological evaluation of affected members from a Dutch DFNA8/12 (TECTA) family. Journal of the Association for Research in Otolaryngology : JARO 22 17136632
2017 Prevalence of TECTA mutation in patients with mid-frequency sensorineural hearing loss. Orphanet journal of rare diseases 21 28946916
2001 Quantification of TECTA and DFNA5 expression in the developing mouse cochlea. Neuroreport 21 11711860
2014 Whole-exome sequencing identifies a novel genotype-phenotype correlation in the entactin domain of the known deafness gene TECTA. PloS one 20 24816743
2011 Structural and mechanical analysis of tectorial membrane Tecta mutants. Biophysical journal 20 21575588
2007 Audioprofiling identifies TECTA and GJB2-related deafness segregating in a single extended pedigree. Clinical genetics 20 17661817
2008 Characterization of a spontaneous, recessive, missense mutation arising in the Tecta gene. Journal of the Association for Research in Otolaryngology : JARO 19 18452040
2002 Redefining gonadotropin-releasing hormone (GnRH) cell groups in the male Syrian hamster: testosterone regulates GnRH mRNA in the tenia tecta. Journal of neuroendocrinology 19 12000543
2006 Species identification of Kachuga tecta using the cytochrome b gene. Journal of forensic sciences 17 16423223
2010 Tectorial membrane material properties in Tecta(Y)(1870C/+) heterozygous mice. Biophysical journal 16 21081075
2008 Flat threshold and mid-frequency hearing impairment in a Dutch DFNA8/12 family with a novel mutation in TECTA. Some evidence for protection of the inner ear. Audiology & neuro-otology 14 19005249
2016 A novel TECTA mutation causes ARNSHL. International journal of pediatric otorhinolaryngology 13 28012541
2012 Aberrant transcript produced by a splice donor site deletion in the TECTA gene is associated with autosomal dominant deafness in a Brazilian family. Gene 13 22995349
2016 A novel biallelic splice site mutation of TECTA causes moderate to severe hearing impairment in an Algerian family. International journal of pediatric otorhinolaryngology 12 27368438
2014 Novel TECTA mutations identified in stable sensorineural hearing loss and their clinical implications. Audiology & neuro-otology 11 25413827
2017 Diverse pattern of gap junction beta-2 and gap junction beta-4 genes mutations and lack of contribution of DFNB21, DFNB24, DFNB29, and DFNB42 loci in autosomal recessive nonsyndromic hearing loss patients in Hormozgan, Iran. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 10 28900455
2018 Spontaneous Otoacoustic Emissions in Tecta Mice Reflect Changes in Cochlear Amplification and How It Is Controlled by the Tectorial Membrane. eNeuro 9 30627650
1988 Development of the optic tecta in the frog Limnodynastes dorsalis. Brain research. Developmental brain research 9 3233731
2014 A Japanese family showing high-frequency hearing loss with KCNQ4 and TECTA mutations. Acta oto-laryngologica 7 24655070
2013 Identification of a Novel TECTA mutation in a Chinese DFNA8/12 family with prelingual progressive sensorineural hearing impairment. PloS one 7 23936151
2016 Genetic Linkage Analysis of DFNB3, DFNB9 and DFNB21 Loci in GJB2 Negative Families with Autosomal Recessive Non-syndromic Hearing Loss. Iranian journal of public health 6 27398341
2014 A novel mutation in the TECTA gene in a Chinese family with autosomal dominant nonsyndromic hearing loss. PloS one 6 24586623
2002 Genetic differentiation between alternate-year cohorts of Xestia tecta (Lepidoptera, Noctuidae) in Finnish Lapland. Hereditas 6 12369104
2024 Reevaluating the splice-altering variant in TECTA as a cause of nonsyndromic hearing loss DFNA8/12 by functional analysis of RNA. Human molecular genetics 5 38676628
2021 Next-Generation Sequencing Identifies Pathogenic Variants in HGF, POU3F4, TECTA, and MYO7A in Consanguineous Pakistani Deaf Families. Neural plasticity 5 33976695
2011 Identification and functional characterization of novel compound heterozygotic mutations in the TECTA gene. Gene 5 22037481
2019 The TECTA mutation R1890C is identified as one of the causes of genetic hearing loss: a case report. BMC medical genetics 4 30935366
2014 A rare novel mutation in TECTA causes autosomal dominant nonsyndromic hearing loss in a Mongolian family. BMC medical genetics 4 25008054
1982 Effects of enucleation on high-affinity binding sites in chick optic tecta. Journal of neurochemistry 4 7108554
2023 Clinical relevance of the TECTA c.6183G>T variant identified in a family with autosomal dominant hearing loss: a case report. Croatian medical journal 3 37927186
2014 Despite a lack of otoacoustic emission, word recognition is not seriously influenced in a TECTA DFNA8/12 family. International journal of pediatric otorhinolaryngology 2 24636747
2005 RT-PCR analysis of Tecta, Coch, Eya4 and Strc in mouse cochlear explants. Neuroreport 2 15729138
2025 A novel splicing variant in TECTA associated with prelingual autosomal dominant nonsyndromic hearing loss via dominant-negative effect. Human molecular genetics 1 40583560
2022 The First Annotated Genome Assembly of Macrophomina tecta Associated with Charcoal Rot of Sorghum. Genome biology and evolution 1 35647618
2019 [Diagnosis and reproductive guidance for a couple carrying a novel c.1893C>T mutation of the TECTA gene]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 1 30703234
2025 Hearing Loss Secondary to TECTA Gene Mutations. The Annals of otology, rhinology, and laryngology 0 39905815
2007 [From gene to disease; DFNA8/12, an autosomal dominant inherited bowl-shaped sensorineural hearing impairment]. Nederlands tijdschrift voor geneeskunde 0 17373394

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