Affinage

TAOK1

Serine/threonine-protein kinase TAO1 · UniProt Q7L7X3

Length
1001 aa
Mass
116.1 kDa
Annotated
2026-06-10
43 papers in source corpus 17 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TAOK1 (MARKK/PSK2) is a Ste20-like serine/threonine kinase that operates as an upstream node integrating cytoskeletal dynamics, MAP kinase signaling, innate immunity, and genome maintenance (PMID:14517247, PMID:16407310). Its founding biochemical activity is phosphorylation of the MARK/PAR-1 activation loop (T208), which drives MARK-mediated phosphorylation of microtubule-associated proteins (tau/MAP2/MAP4) at KXGS motifs and consequent microtubule disassembly (PMID:14517247); this microtubule-regulatory activity is constrained by TESK1 binding, with Spred1 coupling the system to F-actin dynamics (PMID:18216281). Through downstream activation of JNK and cleavage of ROCK-I, TAOK1 drives apoptotic morphological change and is itself a caspase-3 substrate (PMID:16407310). In neurons, TAOK1 directly binds phosphoinositides through a coiled-coil triple-helical region C-terminal to the kinase domain, an association switched off by autophosphorylation at T440/T443; disease-associated catalytically inactive mutants are trapped on the membrane and produce aberrant membrane protrusions and dendritic arbor defects (PMID:36595571), and TAOK1 dosage and activity govern neural migration, neuronal maturation, and—via the dorsal raphe nucleus—social behavior (PMID:33565190, PMID:37656623). In immune signaling TAOK1 acts bidirectionally: it suppresses IL-17 signaling kinase-independently by blocking IL-17RA–Act1 complex assembly (PMID:29400705), yet scaffolds TRAF6–TPL2 to promote TLR4-driven ERK1/2 activation and inflammation (PMID:32344244) and traffics TBK1 along microtubules to IRF3 to support type I IFN production (PMID:36649698). In the nucleus TAOK1 promotes homologous recombination by phosphorylating USP7 to stabilize RAD51, and its loss sensitizes tumor cells to PARP inhibitors (PMID:40106350). Loss-of-function and dominant-negative TAOK1 variants underlie a neurodevelopmental disorder, consistent with its roles in neuronal morphogenesis and behavior (PMID:31230721, PMID:33565190).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2003 High

    Established TAOK1's foundational catalytic activity by identifying it as the kinase that activates MARK/PAR-1, explaining how an upstream signal controls microtubule-associated protein detachment.

    Evidence In vitro kinase assay with phosphosite mapping (T208 of MARK2) plus cellular readout of tau phosphorylation and microtubule dynamics

    PMID:14517247

    Open questions at the time
    • Did not define upstream activators of TAOK1 itself
    • Physiological contexts of MARK activation not addressed
  2. 2006 High

    Placed TAOK1 in an apoptotic signaling axis, showing it drives apoptotic morphology through JNK and ROCK-I and is itself regulated by caspase cleavage.

    Evidence Overexpression, dominant-negative JNK, pharmacological inhibitors and caspase substrate assays in cultured cells

    PMID:16407310

    Open questions at the time
    • Direct substrates linking TAOK1 to JNK activation not identified
    • Whether caspase cleavage is activating or inactivating unresolved
  3. 2008 High

    Defined regulatory inputs to TAOK1, showing TESK1 binds and inhibits it while Spred1 links its control to F-actin, integrating microtubule and actin cytoskeleton regulation.

    Evidence Yeast two-hybrid, Co-IP and overexpression/knockdown in CHO cells with cytoskeletal readouts

    PMID:18216281

    Open questions at the time
    • Mechanism by which TESK1 inhibits kinase activity not structurally defined
    • Physiological stimulus controlling this switch unknown
  4. 2018 High

    Revealed a kinase-independent scaffolding function, showing TAOK1 suppresses IL-17 signaling by blocking IL-17RA–Act1 complex formation.

    Evidence Co-IP, siRNA, kinase-dead mutant and TAOK1-deficient mouse colitis model

    PMID:29400705

    Open questions at the time
    • Structural basis of IL-17RA binding not determined
    • How kinase-dependent and -independent functions are partitioned unclear
  5. 2019 Medium

    Connected TAOK1 loss to a defined cellular and neuronal phenotype, supporting its role in a neurodevelopmental disorder.

    Evidence Patient fibroblast phospho-tau/phospho-TAO1 Western blots and Drosophila Tao1 RNAi with NMJ/mitochondria imaging

    PMID:31230721

    Open questions at the time
    • Mechanism linking TAOK1 to mitochondrial morphology not established
    • Pathway placement of neuronal phenotype partial
  6. 2020 High

    Showed a context-opposite immune role, with TAOK1 scaffolding TRAF6–TPL2 to promote TLR4/ERK-driven inflammation.

    Evidence Constitutive Co-IP, siRNA and TAOK1-deficient mouse endotoxin shock model

    PMID:32344244

    Open questions at the time
    • Whether TAOK1 kinase activity is required not dissected
    • Relationship to its IL-17-suppressive role unexplained
  7. 2021 Medium

    Demonstrated dosage-sensitivity of TAOK1 in brain development and that disease variants act by loss-of-function or dominant-negative mechanisms.

    Evidence In utero electroporation neural migration assay and primary neuron maturation assays with TAOK1 manipulation

    PMID:33565190

    Open questions at the time
    • Molecular substrates in migrating neurons not identified
    • Distinction between LOF and dominant-negative variant mechanisms incomplete
  8. 2023 High

    Defined a direct membrane-remodeling mechanism, showing TAOK1 binds phosphoinositides via a triple-helical region switched off by T440/T443 autophosphorylation, and that disease mutants are catalytically dead and membrane-trapped.

    Evidence Phosphoinositide binding and autophosphorylation assays, mutagenesis and morphology in mouse hippocampal neurons with structural modeling

    PMID:36595571

    Open questions at the time
    • In vivo physiological membrane substrates not mapped
    • Crystal/cryo-EM structure of the membrane-bound state lacking
  9. 2023 Medium

    Established a kinase-dependent antiviral role, showing TAOK1 traffics TBK1 along microtubules to IRF3 to promote type I IFN.

    Evidence Reciprocal Co-IP, kinase-dead mutant, microtubule depolymerization and IFN reporter assays

    PMID:36649698

    Open questions at the time
    • TBK1/dynein trafficking switch not independently replicated
    • Phosphorylation target driving IRF3 activation not identified
  10. 2023 High

    Linked TAOK1 kinase activity to social behavior through dorsal raphe nucleus neurons, providing in vivo causal evidence for autism-like phenotypes.

    Evidence VGlut3-Cre conditional knockout, AAV rescue with WT vs kinase-dead TAOK1, in vivo calcium imaging and phosphoproteomics

    PMID:37656623

    Open questions at the time
    • Behaviorally relevant phosphorylation substrates in DRN neurons not pinpointed
    • Circuit downstream of DRN not mapped
  11. 2023 Medium

    Extended TAOK1 to metabolic regulation, implicating TAOK1/p38-MAPK/FoxO3 signaling in muscle protein degradation and cachexia, and lipid-droplet-associated ERK/JNK signaling in hepatocytes.

    Evidence Direct binding (pull-down, microscale thermophoresis), siRNA, pathway inhibition, tumor-bearing mouse model; and hepatocyte siRNA with lipid-droplet colocalization imaging

    PMID:36930872 PMID:37439183

    Open questions at the time
    • Direct phosphorylation substrates in p38/FoxO3 axis not defined
    • Hepatocyte lipid-droplet role single-lab without replication
  12. 2024 Medium

    Placed TAOK1 upstream of the Hippo pathway via STK3/MST2 phosphorylation, with an lncRNA-mediated disruption mechanism affecting YAP1 localization.

    Evidence Co-IP, RNA pull-down, STK3 phosphorylation assays and YAP1 localization imaging

    PMID:39528458

    Open questions at the time
    • Direct STK3 phosphosite not mapped
    • Physiological relevance beyond cancer context unknown
  13. 2025 High

    Identified a nuclear genome-maintenance role, showing TAOK1 phosphorylates USP7 to stabilize RAD51 and enable homologous recombination, with therapeutic relevance to PARP inhibitor sensitivity.

    Evidence Kinase inhibitor screen, in vitro kinase assay, Co-IP, RAD51 ubiquitylation/degradation and HR reporter assays in cancer cells

    PMID:40106350

    Open questions at the time
    • USP7 phosphosite and how it enhances DUB activity not fully defined
    • How TAOK1 is recruited to sites of HR repair unknown
  14. 2025 Medium

    Revealed a kinase-independent role at replication forks, where TAOK1 depletion stabilizes forks and confers PARP inhibitor/IR resistance in BRCA-deficient cells.

    Evidence siRNA/genetic depletion, DNA fiber assays, PCNA Co-IP and ISG15 measurement in BRCA1/2-deficient cells (preprint)

    Open questions at the time
    • Preprint, not yet peer-reviewed
    • Apparent opposition to the HR-promoting role at forks not reconciled

Open questions

Synthesis pass · forward-looking unresolved questions
  • How TAOK1's catalytic versus scaffolding modes are switched across its many contexts—and what upstream signals select among cytoskeletal, immune, metabolic, behavioral, and DNA-repair functions—remains unresolved.
  • No unifying model for context-specific substrate selection
  • Upstream activators of TAOK1 across pathways largely uncharacterized
  • Reconciliation of opposing pro- and anti-inflammatory and pro- and anti-fork-stability roles lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 3 GO:0140096 catalytic activity, acting on a protein 3 GO:0060089 molecular transducer activity 2 GO:0008289 lipid binding 1 GO:0140657 ATP-dependent activity 1
Localization
GO:0005856 cytoskeleton 2 GO:0005634 nucleus 1 GO:0005811 lipid droplet 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-162582 Signal Transduction 3 R-HSA-168256 Immune System 3 R-HSA-5357801 Programmed Cell Death 1 R-HSA-73894 DNA Repair 1
Partners
MARK2SPRED1STK3TBK1TESK1TPL2TRAF6USP7

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 MARKK (TAOK1) is a Ste20-like kinase that acts as an upstream activator of MARK/PAR-1 by phosphorylating MARK within its activation loop at T208 (in MARK2). This phosphorylation activates MARK, leading to downstream phosphorylation of microtubule-associated proteins (tau/MAP2/MAP4) at KXGS motifs, causing their detachment from microtubules and microtubule disassembly. In vitro kinase assay, phosphorylation site mapping, cell overexpression with readout of microtubule dynamics and tau phosphorylation The EMBO journal High 14517247
2008 MARKK/TAOK1 interacts with Spred1 and TESK1 via yeast two-hybrid and cellular assays. TESK1 binds to and inhibits MARKK/TAOK1, thereby blocking MARKK-mediated microtubule disruption. Spred1 binds MARKK without affecting its activity but inhibits TESK1, thus making F-actin fibers dynamic. This three-way interaction links regulation of both the microtubule and F-actin cytoskeleton. Yeast two-hybrid, co-immunoprecipitation, overexpression/knockdown in CHO cells with readout of microtubule and actin cytoskeletal organization Molecular biology of the cell High 18216281
2006 PSK2 (TAOK1) activates JNK and induces apoptotic morphological changes (cell contraction, membrane blebbing, apoptotic body formation). PSK2 stimulates cleavage of ROCK-I, and both JNK and ROCK-I activities are required downstream of PSK2 to produce these apoptotic morphological responses. PSK2 is itself a substrate for caspase 3. Apoptotic stimuli increase endogenous PSK2 catalytic activity. Overexpression, dominant-negative JNK, pharmacological inhibitors, kinase activity assay, caspase substrate assay in cultured cells The Journal of biological chemistry High 16407310
2018 TAOK1 functions as a negative regulator of IL-17-mediated signaling. TAOK1 interacts with IL-17 receptor A (IL-17RA) independently of its kinase activity, and dose-dependently prevents formation of the IL-17R–Act1 complex, thereby suppressing downstream MAPK and NF-κB activation. TAOK1 knockdown promotes IL-17-induced cytokine/chemokine expression, and TAOK1-deficient mice show exacerbated colitis in a TNBS model. Co-immunoprecipitation, siRNA knockdown, overexpression, TAOK1-deficient mouse model with inflammatory readout Cellular & molecular immunology High 29400705
2020 TAOK1 positively regulates TLR4-induced inflammatory responses in macrophages by constitutively interacting with TRAF6 and TPL2, promoting LPS-induced ERK1/2 activation and pro-inflammatory cytokine production. TAOK1-deficient mice show decreased susceptibility to endotoxin shock. Co-immunoprecipitation, siRNA knockdown, TAOK1-deficient mice with LPS/endotoxin shock model, cytokine measurement Molecular immunology High 32344244
2023 TAOK1 functions as a plasma membrane remodeling kinase. It directly associates with phosphoinositides via a coiled-coil triple-helical region C-terminal to the kinase domain. Autophosphorylation of T440 and T443 in this triple-helical region by the kinase domain blocks plasma membrane association. NDD-associated TAOK1 mutants are catalytically inactive, aberrantly trapped in a membrane-bound state, and induce abnormal membrane protrusions and abnormal dendritic arbor growth in cultured mouse hippocampal neurons. Phosphoinositide binding assay, autophosphorylation assay, mutagenesis, expression in cultured mouse hippocampal neurons with morphological readout, in silico structural modeling Science signaling High 36595571
2023 TAOK1 controls antiviral innate immune responses by constitutively associating with TBK1 (independently of MAVS), promoting IRF3 activation by enhancing TBK1-IRF3 complex formation. Viral infection induces TAOK1 to switch binding from MAP4 to dynein, facilitating trafficking of TBK1 along microtubules to the perinuclear region where it binds IRF3. Microtubule depolymerization impairs virus-mediated IRF3 activation. TAOK1 promotes type I IFN production in a kinase activity-dependent manner. Co-immunoprecipitation, siRNA knockdown, kinase-dead mutant, microtubule depolymerization experiments, reporter assay for IFN production Journal of innate immunity Medium 36649698
2019 Loss of TAOK1 in patient-derived fibroblasts results in undetectable phosphorylated TAO1 kinase and phosphorylated tau, and alters mitochondrial morphology. Knockdown of the Drosophila ortholog Tao1 causes altered ventral nerve cord and neuromuscular junction morphology, decreased synaptic bouton number, and altered mitochondrial distribution and size in motor neuron axons. Patient-derived fibroblast analysis (Western blot for phospho-tau/phospho-TAO1), Drosophila Tao1 RNAi knockdown with NMJ/mitochondria imaging American journal of human genetics Medium 31230721
2021 Altered TAOK1 expression levels in the embryonic mouse brain affect neural migration in vivo, and neuronal maturation in vitro. Missense variants can have loss-of-function or dominant-negative effects on TAOK1 activity. In utero electroporation for neural migration assay in mouse embryos, primary neuron cultures with TAOK1 manipulation Human mutation Medium 33565190
2023 TAOK1 promotes the TAOK1/p38-MAPK/FoxO3 pathway in muscle to regulate protein degradation via the ubiquitin-proteasome system and autophagy. CYA was found to directly bind TAOK1 (biotin-streptavidin pull-down, microscale thermophoresis), inhibiting its activation and downstream p38-MAPK signaling, reducing FoxO3 nuclear localization, and ameliorating muscle atrophy in cancer cachexia. Biotin-streptavidin pull-down, microscale thermophoresis binding assay, siRNA knockdown, p38-MAPK pathway pharmacological activation/inhibition, Western blotting, C26 tumor-bearing mouse model Journal of cachexia, sarcopenia and muscle Medium 37439183
2023 TAOK1 haploinsufficiency in mice leads to autistic-like behaviors associated with reduced activation of dorsal raphe nucleus (DRN) neurons during social interactions. Genetic deletion of Taok1 specifically in VGlut3-positive DRN neurons recapitulates the social behavior deficit. Reintroduction of wild-type TAOK1, but not a kinase-dead variant, into the DRN of adult mice rescues the autistic-like behaviors, indicating that TAOK1's kinase activity is required for normal social behavior. Conditional knockout (VGlut3-Cre), AAV rescue with wild-type vs. kinase-dead TAOK1, in vivo calcium imaging of DRN neurons during social interaction, phosphoproteomics Cell reports High 37656623
2023 TAOK1 silencing in human hepatocytes inhibits ERK and JNK activation and represses acetyl-CoA carboxylase (ACC) protein abundance, and TAOK1 protein colocalizes with intracellular lipid droplets in human and mouse hepatocytes. siRNA knockdown, immunofluorescence microscopy for colocalization with lipid droplets, Western blotting for ERK/JNK/ACC, functional metabolic assays Hepatology communications Medium 36930872
2025 TAOK1 promotes homologous recombination (HR) repair by phosphorylating USP7, enhancing USP7 deubiquitylase activity and thereby preventing ubiquitylation and degradation of RAD51, which is required for RAD51 filament formation in HR repair. Genetic depletion or pharmacological inhibition of TAOK1 leads to RAD51 degradation, disrupted HR, and increased tumor cell sensitivity to PARP inhibitors. High-throughput kinase inhibitor screen, in vitro kinase assay (TAOK1 phosphorylates USP7), Co-IP, RAD51 ubiquitylation/degradation assay, HR repair reporter, PARP inhibitor sensitivity assay in human cancer cells Proceedings of the National Academy of Sciences of the United States of America High 40106350
2024 TAOK1 interacts with STK3 (MST2) to phosphorylate it, activating the Hippo kinase cascade and leading to YAP1 phosphorylation and cytoplasmic retention. The lncRNA ELFN1-AS1 binds the kinase domain of TAOK1 and disrupts the TAOK1-STK3 interaction, reducing STK3 phosphorylation, decreasing YAP1 phosphorylation, and promoting YAP1 nuclear translocation and MYC expression. Co-immunoprecipitation, RNA pull-down (ELFN1-AS1 with TAOK1), phosphorylation assay for STK3, YAP1 localization by imaging, rescue experiments Cell death discovery Medium 39528458
2024 TAOK1 interacts with CDC20 as shown by co-immunoprecipitation in human umbilical vein endothelial cells. TAOK1 overexpression counteracts ox-LDL-induced apoptosis, senescence, and pro-inflammatory signaling; these protective effects are reversed by CDC20 siRNA knockdown. Co-immunoprecipitation, siRNA knockdown of CDC20, overexpression, flow cytometry for apoptosis, β-galactosidase staining for senescence Discovery medicine Low 39726311
2025 Schip1 interacts with Taok1 to activate the p38 MAPK signaling pathway, promoting osteoclast differentiation. Suppression of Schip1 reduces Rankl-induced osteoclast formation, and Schip1 genetic ablation in mice results in osteosclerosis and protection from ovariectomy-induced osteoporosis. Co-immunoprecipitation (Schip1-Taok1 interaction), siRNA knockdown, genetic ablation in mice, osteoclast differentiation assay, ovariectomy model Bone Medium 40633827
2025 TAOK1 regulates replication fork (RF) stability in a kinase activity-independent manner. TAOK1 depletion stabilizes replication forks and reduces replication-associated DNA damage in BRCA1/2-deficient cells, conferring resistance to PARP inhibitors and ionizing radiation. TAOK1 interacts with PCNA and regulates ISG15 levels to affect RF stability. siRNA/genetic depletion, DNA fiber assay for RF stability, Co-IP with PCNA, ISG15 level measurement, PARP inhibitor and IR sensitivity assays in BRCA1/2-deficient cells bioRxivpreprint Medium
2025 TAOK1 MAPK signaling is activated downstream of GADD45B (a DNA demethylation sensor). Betulin increases DNA methylation at the TAOK1 promoter and decreases TAOK1 expression, attenuating p38 MAPK activation and reducing apoptosis in intestinal epithelial cells during sepsis. Overexpression of GADD45B or TAOK1 reversed the anti-apoptotic effect of betulin. qMSP (methylation-specific PCR), Western blotting, overexpression rescue, CLP mouse model, LPS-induced IEC-6 cell model Journal of ethnopharmacology Low 40653040

Source papers

Stage 0 corpus · 43 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. The EMBO journal 165 14517247
2019 miR-381-abundant small extracellular vesicles derived from kartogenin-preconditioned mesenchymal stem cells promote chondrogenesis of MSCs by targeting TAOK1. Biomaterials 59 31864017
2008 Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton. Molecular biology of the cell 54 18216281
2018 TAOK1 negatively regulates IL-17-mediated signaling and inflammation. Cellular & molecular immunology 50 29400705
2006 Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1. The Journal of biological chemistry 44 16407310
2019 De Novo Variants in TAOK1 Cause Neurodevelopmental Disorders. American journal of human genetics 38 31230721
2021 TAOK1 is associated with neurodevelopmental disorder and essential for neuronal maturation and cortical development. Human mutation 37 33565190
2013 The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma. PloS one 36 23472202
2016 miR-706 inhibits the oxidative stress-induced activation of PKCα/TAOK1 in liver fibrogenesis. Scientific reports 30 27876854
2024 A global phosphosite-correlated network map of Thousand And One Kinase 1 (TAOK1). The international journal of biochemistry & cell biology 29 38479581
2023 Corylifol A ameliorates muscle atrophy by inhibiting TAOK1/p38-MAPK/FoxO3 pathway in cancer cachexia. Journal of cachexia, sarcopenia and muscle 20 37439183
2022 Inherited and de novo variants extend the etiology of TAOK1-associated neurodevelopmental disorder. Cold Spring Harbor molecular case studies 16 35091509
2021 Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach. Journal of enzyme inhibition and medicinal chemistry 16 33167727
2023 Neurodevelopmental disorder-associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase. Science signaling 14 36595571
2022 TAOK1 Promotes Proliferation and Invasion of Non-Small-Cell Lung Cancer Cells by Inhibition of WWC1. Computational and mathematical methods in medicine 12 36158126
2020 TAOK1 positively regulates TLR4-induced inflammatory responses by promoting ERK1/2 activation in macrophages. Molecular immunology 12 32344244
2023 Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic rewiring. Hepatology communications 11 36930872
1984 Construction of plasmid vectors from Streptomyces kasugaensis plasmids, pSK1 and pSK2. The Journal of antibiotics 11 6094413
2023 Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus. Cell reports 7 37656623
2024 Targeting TAOK1 with resveratrol inhibits esophageal squamous cell carcinoma growth in vitro and in vivo. Molecular carcinogenesis 5 38376345
2024 Expanding the phenotype and genotype spectrum of TAOK1 neurodevelopmental disorder and delineating TAOK2 neurodevelopmental disorder. Genetics in medicine : official journal of the American College of Medical Genetics 5 39737487
2011 PSK2 coordinates glucose metabolism and utilization to maintain ultradian clock-coupled respiratory oscillation in Saccharomyces cerevisiae yeast. Archives of biochemistry and biophysics 5 21345330
2024 lincRNA00907 promotes NASH progression by targeting miRNA-942-5p/TAOK1. Aging 4 38613803
2024 TAOK1-mediated regulation of the YAP/TEAD pathway as a potential therapeutic target in heart failure. PloS one 4 39121041
2024 The long noncoding RNA ELFN1-AS1 promotes gastric cancer growth and metastasis by interacting with TAOK1 to inhibit the Hippo signaling pathway. Cell death discovery 4 39528458
2015 Identification of Psk2, Skp1, and Tub4 as trans-acting factors for uORF-containing ROK1 mRNA in Saccharomyces cerevisiae. Journal of microbiology (Seoul, Korea) 4 26310304
2021 MiR-200c-3p affects cochlear hair cells damaged by oxidative stress via modulating Taok1 expression. American journal of translational research 3 35035705
2026 PAD4+ neutrophils promote hepatic stellate cell activation and accelerate MASH fibrosis progression viaNET-DNA/TAOK1/MAPK pathways. JCI insight 2 41480748
2025 Shenling Baizhu Powder and Betulin attenuate sepsis-induced intestinal injury by targeting GADD45B/TAOK1/p38 MAPK pathway. Journal of ethnopharmacology 2 40653040
2024 Heterozygous truncating variant of TAOK1 in a boy with periventricular nodular heterotopia: a case report and literature review of TAOK1-related neurodevelopmental disorders. BMC medical genomics 2 38443934
2023 Ste20-Like Kinase TAOK1 Positively Regulates Antiviral Responses by Controlling the TBK1-IRF3 Signaling Axis. Journal of innate immunity 2 36649698
2023 Activity-dependent membrane sculpting deficits in TAOK1-linked neurodevelopmental disease. Trends in neurosciences 2 37230852
2022 [The role and mechanism of lncRNA C9ORF139 targeting miR-24-3P/TAOK1 in regulating the proliferation of acute myeloid leukemia cells]. Zhonghua yi xue za zhi 2 35196780
2025 TAOK1 promotes filament formation in HR repair through phosphorylating USP7. Proceedings of the National Academy of Sciences of the United States of America 1 40106350
2025 LncRNA C9orf139 Promotes Acute Myeloid Leukemia Cell Proliferation by Sponging miR-24-3p to Upregulate TAOK1. Current medical science 1 41296255
2024 Protective Role of TAOK1-CDC20 Axis in Atherosclerosis: Modulation of Endothelial Apoptosis and Senescence. Discovery medicine 1 39726311
2023 Isolation and characterization of vB_SenS_Ib_psk2 bacteriophage against drug-resistant Salmonella enterica serovar Kentucky. Folia microbiologica 1 37074624
2026 Discovery of VU6083859, a TAOK1 Selective Inhibitor, and VU6080195, a pan-TAOK Activator. ACS chemical neuroscience 0 41530942
2025 Deferasirox Targets TAOK1 to Induce p53-Mediated Apoptosis in Esophageal Squamous Cell Carcinoma. International journal of molecular sciences 0 40003990
2025 The potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy. Pharmacological research 0 40339965
2025 Schip1 promotes osteoclast differentiation via Taok1-mediated activation of the p38 MAPK signaling pathway in mouse models of osteoporosis. Bone 0 40633827
2025 Corylifol A ameliorates pancreatic cancer-associated cachexia by targeting TAOK3 in pancreatic cancer cells and targeting TAOK1 in skeletal muscle cells. Toxicology and applied pharmacology 0 41110813
2025 LINC01198 activates Hippo signaling to stimulate IL-1β autocrine for driving vemurafenib resistance by associating with TAOK1/2 in melanoma. Cell death discovery 0 41145465

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