Affinage

TAOK1

Serine/threonine-protein kinase TAO1 · UniProt Q7L7X3

Length
1001 aa
Mass
116.1 kDa
Annotated
2026-04-28
44 papers in source corpus 18 papers cited in narrative 18 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TAOK1 is a Ste20-family serine/threonine kinase that functions as a signaling hub linking cytoskeletal regulation, innate immunity, DNA repair, and neuronal development. It directly phosphorylates the MARK2 activation loop (T208) to drive microtubule disassembly and neurite outgrowth (PMID:14517247), binds plasma membrane phosphoinositides via a C-terminal coiled-coil triple-helical region with autophosphorylation at T440/T443 terminating membrane association to control dendritic arbor morphology (PMID:36595571), and phosphorylates USP7 to stabilize RAD51 and promote homologous recombination repair (PMID:40106350). TAOK1 also scaffolds innate immune signaling complexes—constitutively associating with TBK1 to facilitate microtubule-dependent TBK1–IRF3 antiviral signaling (PMID:36649698), interacting with TRAF6–TPL2 to promote TLR4-triggered ERK1/2 activation (PMID:32344244), and suppressing IL-17R–Act1 complex formation in a kinase-independent manner (PMID:29400705)—while activating p38-MAPK to drive FoxO3-dependent muscle protein degradation in cancer cachexia (PMID:37439183) and Hippo pathway signaling through STK3/LATS (PMID:39528458). De novo loss-of-function and dominant-negative TAOK1 variants cause neurodevelopmental disorder characterized by impaired cortical neuronal migration, altered mitochondrial morphology, and autistic-like social behavior deficits arising from dorsal raphe nucleus dysfunction (PMID:33565190, PMID:31230721, PMID:37656623).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2003 High

    Identifying TAOK1 as the activating kinase upstream of MARK/PAR-1 established the first defined substrate and linked TAOK1 to microtubule dynamics and cell polarity.

    Evidence In vitro kinase assay with T208 mutagenesis in MARK2, cell-based microtubule disassembly and neurite outgrowth readouts

    PMID:14517247

    Open questions at the time
    • Other MARK activation-loop kinases not excluded
    • In vivo requirement for TAOK1-MARK axis not tested
  2. 2008 High

    Discovery of TESK1 as a TAOK1 inhibitor and Spred1 as a binding partner revealed a three-way regulatory circuit connecting microtubule and actin cytoskeleton dynamics upstream and downstream of TAOK1.

    Evidence Yeast two-hybrid, reciprocal Co-IP, CHO cell cytoskeletal phenotype assays

    PMID:18216281

    Open questions at the time
    • Structural basis of TESK1 inhibition unknown
    • Physiological context of Spred1-TESK1-TAOK1 network not defined in vivo
  3. 2018 High

    Demonstrating that TAOK1 suppresses IL-17 signaling by physically blocking IL-17RA–Act1 interaction in a kinase-independent manner established a scaffolding role distinct from its catalytic functions.

    Evidence Co-IP, kinase-dead mutant, TAOK1 knockdown with cytokine readout, in vivo colitis model

    PMID:29400705

    Open questions at the time
    • Binding interface between TAOK1 and IL-17RA not mapped
    • Relative contribution versus other IL-17R regulators unknown
  4. 2019 Medium

    Patient-derived de novo TAOK1 variants causing nonsense-mediated decay and loss of kinase activity linked TAOK1 haploinsufficiency to neurodevelopmental disorder, with altered mitochondrial morphology in patient fibroblasts and Drosophila neurons providing the first disease-associated phenotypes.

    Evidence Patient fibroblast NMD assay, Western blot for p-TAO1/p-tau, mitochondrial imaging, Drosophila Tao1 knockdown NMJ analysis

    PMID:31230721

    Open questions at the time
    • Mechanism by which TAOK1 controls mitochondrial morphology not defined
    • Patient cohort limited; genotype-phenotype correlation incomplete
  5. 2020 High

    Identification of constitutive TAOK1–TRAF6–TPL2 complex formation driving TLR4-triggered ERK1/2 activation expanded TAOK1's immune role to innate inflammatory signaling in macrophages.

    Evidence Co-IP of endogenous complex, TAOK1-KO mice with reduced endotoxin shock susceptibility

    PMID:32344244

    Open questions at the time
    • Direct phosphorylation of TPL2 or TRAF6 by TAOK1 not demonstrated
    • Kinase-dependent versus scaffolding role in TLR4 pathway not dissected
  6. 2021 High

    In utero electroporation and functional characterization of NDD-associated missense variants demonstrated that both TAOK1 loss-of-function and dominant-negative alleles disrupt cortical neuronal migration and maturation, establishing dosage sensitivity.

    Evidence In utero electroporation migration assay, primary neuron maturation assay, patient fibroblast analysis

    PMID:33565190

    Open questions at the time
    • Downstream substrates mediating migration defect not identified
    • Whether dominant-negative effect operates through MARK or another pathway unclear
  7. 2023 High

    Reconstitution of direct phosphoinositide binding by the TAOK1 coiled-coil triple helix and identification of T440/T443 autophosphorylation as a membrane-release switch revealed how catalytic activity self-limits membrane association, explaining why kinase-dead NDD mutants become trapped at the membrane and cause aberrant dendritic morphology.

    Evidence In vitro phospholipid-binding assay, autophosphorylation mutagenesis, live-cell imaging, hippocampal neuron morphology

    PMID:36595571

    Open questions at the time
    • Crystal structure of the triple-helical membrane-binding domain not solved
    • Whether membrane trapping fully explains NDD pathogenesis not tested in vivo
  8. 2023 High

    Demonstration that TAOK1 switches from MAP4 to dynein binding upon viral infection to traffic TBK1 along microtubules to perinuclear IRF3 established a microtubule-dependent antiviral signaling mechanism requiring TAOK1 kinase activity.

    Evidence Co-IP of TAOK1–TBK1/dynein/MAP4, kinase-dead mutant, microtubule depolymerization, type I IFN assay

    PMID:36649698

    Open questions at the time
    • Direct TAOK1 phosphorylation target in TBK1–IRF3 axis not identified
    • Trigger for MAP4-to-dynein switch at the molecular level unknown
  9. 2023 High

    Identification of TAOK1–p38-MAPK–FoxO3 signaling driving ubiquitin-proteasome and autophagy-lysosome pathways in cancer cachexia-associated muscle atrophy, with Corylifol A validated as a direct TAOK1-binding inhibitor, connected TAOK1 to metabolic muscle wasting.

    Evidence Biotin-streptavidin pulldown and microscale thermophoresis for Corylifol A binding, siRNA epistasis, tumor-bearing mouse model

    PMID:37439183

    Open questions at the time
    • Direct p38 phosphorylation by TAOK1 versus intermediate kinase not resolved
    • Whether Corylifol A is selective for TAOK1 over TAOK2/3 not fully profiled
  10. 2023 High

    Cell-type-specific deletion of Taok1 in VGlut3-positive dorsal raphe neurons recapitulated autistic-like social behavior, and rescue required kinase-active TAOK1, pinpointing the neural circuit and enzymatic requirement for TAOK1 in social behavior.

    Evidence Conditional Cre-mediated KO, viral kinase-dead rescue, in vivo calcium imaging of DRN neurons, behavioral assays

    PMID:37656623

    Open questions at the time
    • DRN substrates of TAOK1 kinase not identified
    • Whether downstream mechanism involves MARK, p38, or a novel pathway not determined
  11. 2025 High

    TAOK1 phosphorylation of USP7 to stabilize RAD51 for homologous recombination established a new catalytic substrate and linked TAOK1 to DNA repair and PARP inhibitor sensitivity.

    Evidence In vitro kinase assay (TAOK1 phosphorylating USP7), ubiquitylation assay, RAD51 foci assay, HR reporter, PARP inhibitor sensitization

    PMID:40106350

    Open questions at the time
    • Specific USP7 phosphorylation site(s) not mapped
    • Relative contribution of TAOK1 versus TAOK2/3 to HR in vivo not resolved
  12. 2025 Medium

    TAOK1 interaction with Schip1 activating p38 MAPK to promote osteoclast differentiation extended TAOK1's p38-activating role to bone remodeling.

    Evidence Co-IP (Schip1–Taok1), Schip1 KO mice with osteosclerosis phenotype, osteoclast differentiation assay

    PMID:40633827

    Open questions at the time
    • Whether TAOK1 is the sole Schip1-activated kinase not excluded
    • Direct TAOK1 kinase substrate in osteoclast differentiation unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key open questions include the structural basis for TAOK1's phosphoinositide binding and membrane release, the full phosphoproteome of TAOK1 substrates across its diverse cellular roles, how TAOK1 kinase activity versus scaffolding functions are differentially regulated in immune versus neuronal contexts, and the mechanism by which TAOK1 controls replication fork stability independent of its kinase activity.
  • No structural model of TAOK1 triple-helical domain or kinase domain with substrates
  • Full phosphoproteome of TAOK1 not characterized
  • Kinase-independent replication fork stabilization mechanism not reconstituted

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 4 GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 3 GO:0008289 lipid binding 1
Localization
GO:0005856 cytoskeleton 2 GO:0005811 lipid droplet 1 GO:0005829 cytosol 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 8 R-HSA-1266738 Developmental Biology 4 R-HSA-168256 Immune System 3 R-HSA-5357801 Programmed Cell Death 1 R-HSA-73894 DNA Repair 1
Partners
IL17RAMARK2PCNATBK1TESK1TPL2TRAF6USP7
Complex memberships
TBK1–TAOK1TRAF6–TPL2–TAOK1

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 MARKK (TAOK1) is an upstream activator of MARK/PAR-1 kinase; it phosphorylates MARK2 within the activation loop at T208, activating MARK and leading to downstream phosphorylation of microtubule-associated proteins (tau/MAP2/MAP4) at KXGS motifs, causing microtubule disassembly and, in neuronal cells, promoting neurite outgrowth. In vitro kinase assay, site-directed mutagenesis (T208 in MARK2), cell overexpression with microtubule dynamics readout The EMBO journal High 14517247
2008 MARKK/TAO1 (TAOK1) interacts with two new binding partners identified by yeast two-hybrid: Spred1 (which binds MARKK without affecting its activity) and TESK1 (which binds and inhibits MARKK). TESK1 blocks MARKK-driven microtubule disruption, while Spred1 relieves TESK1 inhibition of cofilin phosphorylation, creating a three-way regulatory network linking microtubule and F-actin cytoskeleton dynamics. Yeast two-hybrid, co-immunoprecipitation, CHO cell overexpression with cytoskeletal phenotype readout Molecular biology of the cell High 18216281
2006 PSK2 (a TAOK1-related Ste20-like kinase) activates JNK and induces apoptotic morphology (cell contraction, membrane blebbing, apoptotic body formation); it also stimulates ROCK-I cleavage, and caspase 3 cleaves PSK2 itself; dominant-negative JNK or ROCK-I inhibition blocked these morphological responses, establishing PSK2 as an upstream regulator of JNK and ROCK-I in the execution phase of apoptosis. Dominant-negative expression, kinase activity assay, caspase substrate assay, morphological readout The Journal of biological chemistry Medium 16407310
2018 TAOK1 negatively regulates IL-17 signaling by physically interacting with IL-17 receptor A (IL-17RA) in a kinase-activity-independent manner and dose-dependently preventing formation of the IL-17R–Act1 complex, thereby suppressing downstream MAP kinase and NF-κB activation. Co-immunoprecipitation, TAOK1 knockdown with cytokine/signaling readout, kinase-dead mutant analysis, in vivo colitis model Cellular & molecular immunology High 29400705
2020 TAOK1 positively regulates TLR4-triggered inflammatory responses in macrophages by constitutively interacting with TRAF6 and TPL2, promoting LPS-induced ERK1/2 activation and pro-inflammatory cytokine production; TAOK1-deficient mice showed decreased susceptibility to endotoxin shock. Co-immunoprecipitation (TAOK1–TRAF6–TPL2 complex), TAOK1 knockdown/KO with ERK1/2 phosphorylation readout, in vivo endotoxin shock model Molecular immunology High 32344244
2021 Altered TAOK1 expression levels in the embryonic mouse brain affect neural migration in vivo and neuronal maturation in vitro; missense NDD-associated variants can act as loss-of-function or dominant-negative alleles, establishing that TAOK1 kinase activity must be properly controlled for normal neuronal function. In utero electroporation (neural migration assay), primary neuron culture (maturation assay), patient fibroblast analysis, functional characterization of missense variants Human mutation High 33565190
2023 TAOK1 is a plasma membrane remodeling kinase: its coiled-coil triple-helical region C-terminal to the kinase domain directly binds phosphoinositides, targeting TAOK1 to the plasma membrane. Autophosphorylation of T440 and T443 within this region by the kinase domain blocks membrane association. NDD-associated TAOK1 missense mutants are catalytically inactive, become aberrantly trapped in a membrane-bound state, and induce abnormal membrane protrusions and aberrant dendritic arbor growth in hippocampal neurons. In vitro phospholipid-binding assay, autophosphorylation assay, mutagenesis of T440/T443, live-cell imaging, primary hippocampal neuron morphology assay, in silico structure prediction of triple helix Science signaling High 36595571
2023 TAOK1 positively regulates antiviral innate immune responses by constitutively associating with TBK1 and enhancing TBK1–IRF3 complex formation in a kinase-activity-dependent manner; viral infection induces TAOK1 to switch from binding MAP4 to binding dynein, enabling trafficking of TBK1 along microtubules to the perinuclear region where it binds IRF3, and microtubule depolymerization impairs this IRF3 activation. Co-immunoprecipitation (TAOK1–TBK1, TAOK1–dynein, TAOK1–MAP4), kinase-dead mutant, microtubule depolymerization, type I IFN production assay Journal of innate immunity High 36649698
2023 TAOK1 protein fully colocalizes with intracellular lipid droplets in human and mouse hepatocytes (determined by immunofluorescence); silencing TAOK1 inhibits ERK and JNK activation and represses ACC protein abundance, alleviating hepatocyte lipotoxicity by shifting fatty acid partitioning toward catabolism. Immunofluorescence colocalization, siRNA knockdown, immunoblotting for ERK, JNK, ACC, functional metabolic assays Hepatology communications Medium 36930872
2023 TAOK1 promotes cancer cachexia-associated muscle atrophy by activating the p38-MAPK pathway, leading to FoxO3 nuclear translocation and upregulation of ubiquitin-proteasome and autophagy-lysosome protein degradation pathways; Corylifol A was identified as a direct-binding inhibitor of TAOK1 (confirmed by biotin-streptavidin pulldown and microscale thermophoresis), and its ameliorating effect on muscle atrophy was reversed by siRNA knockdown of TAOK1 or pathway manipulation. Biotin-streptavidin pulldown, microscale thermophoresis, siRNA knockdown, Western blotting (p38/FoxO3 pathway), in vivo tumor-bearing mouse model Journal of cachexia, sarcopenia and muscle High 37439183
2023 Taok1 haploinsufficiency in mice reduces activation of dorsal raphe nucleus (DRN) neurons during social interaction, causes aberrant phosphorylation of numerous proteins, and produces autistic-like behaviors; selective deletion of Taok1 in VGlut3-positive DRN neurons recapitulates this phenotype, and reintroduction of wild-type but not kinase-dead Taok1 into DRN rescues the behavior. Conditional knockout (Cre-mediated), viral rescue with kinase-dead mutant, in vivo calcium imaging of DRN neurons, behavioral assays Cell reports High 37656623
2025 TAOK1 phosphorylates USP7, thereby promoting USP7 deubiquitylase activity and preventing ubiquitylation and degradation of RAD51; this stabilizes RAD51 filament formation at DNA damage sites and supports homologous recombination (HR) repair; genetic or pharmacological inhibition of TAOK1 impairs USP7 function, causes RAD51 degradation, disrupts HR, and sensitizes tumor cells to PARP inhibitors. High-throughput kinase inhibitor screen, in vitro kinase assay (TAOK1 phosphorylating USP7), ubiquitylation assay, RAD51 foci/filament assay, HR reporter assay, PARP inhibitor sensitivity assay Proceedings of the National Academy of Sciences of the United States of America High 40106350
2024 ELFN1-AS1 lncRNA binds to the kinase domain of TAOK1 and disrupts the TAOK1–STK3 (MST2) interaction, leading to decreased STK3 phosphorylation, attenuation of the Hippo kinase cascade, reduced YAP1 phosphorylation, and increased nuclear YAP1/MYC signaling in gastric cancer cells. Co-immunoprecipitation (TAOK1–STK3 interaction), RNA–protein binding assay, Western blotting for Hippo pathway components, loss-of-function experiments Cell death discovery Medium 39528458
2024 TAOK1 interacts with CDC20 (confirmed by Co-IP), and TAOK1 overexpression protects endothelial cells from ox-LDL-induced apoptosis and senescence; CDC20 siRNA reverses these protective effects, placing CDC20 downstream of TAOK1 in endothelial stress signaling. Co-immunoprecipitation (TAOK1–CDC20), siRNA knockdown, flow cytometry for apoptosis and cell cycle, Western blotting Discovery medicine Low 39726311
2025 TAOK1 regulates replication fork (RF) stability independently of its kinase activity; it interacts with PCNA and regulates ISG15 levels to affect RF stability; TAOK1 depletion stabilizes RFs and reduces replication-associated DNA damage in BRCA1/2-deficient cells, conferring resistance to PARP inhibitors and ionizing radiation. CRISPR/siRNA depletion, kinase-dead mutant rescue, Co-IP (TAOK1–PCNA), DNA fiber assay (fork stability), ISG15 immunoblotting, PARP inhibitor/IR sensitivity assay bioRxivpreprint Medium bio_10.1101_2025.10.14.682031
2025 Schip1 interacts with Taok1 to activate the p38 MAPK signaling pathway, promoting osteoclast differentiation; genetic ablation of Schip1 in mice results in osteosclerosis and attenuates ovariectomy-induced osteoporosis. Co-immunoprecipitation (Schip1–Taok1), Schip1 knockout mice, osteoclast differentiation assay, Western blotting for p38 MAPK pathway Bone Medium 40633827
2025 LINC01198 directly associates with TAOK1/2, inhibits their phosphorylation, and elicits downstream Hippo signaling through the TAOK/LATS axis, redistributing YAP/TAZ to the nucleus and promoting IL-1β expression to drive vemurafenib resistance in melanoma. RNA pull-down/Co-IP (LINC01198–TAOK1/2 association), phosphorylation assay, loss-of-function experiments, YAP/TAZ nuclear localization assay Cell death discovery Medium 41145465
2019 De novo variants in TAOK1 reduce mRNA levels via nonsense-mediated mRNA decay, abolish detectable phosphorylated TAO1 kinase and phosphorylated tau, and alter mitochondrial morphology in patient fibroblasts; knockdown of Tao1 in Drosophila alters neuromuscular junction morphology and mitochondrial distribution in motor neuron axons. Patient fibroblast analysis (cycloheximide NMD assay, Western blot for p-TAO1 and p-tau, mitochondrial imaging), Drosophila Tao1 knockdown with NMJ morphology and mitochondrial readout American journal of human genetics Medium 31230721

Source papers

Stage 0 corpus · 44 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. The EMBO journal 165 14517247
2019 miR-381-abundant small extracellular vesicles derived from kartogenin-preconditioned mesenchymal stem cells promote chondrogenesis of MSCs by targeting TAOK1. Biomaterials 58 31864017
2008 Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton. Molecular biology of the cell 54 18216281
2018 TAOK1 negatively regulates IL-17-mediated signaling and inflammation. Cellular & molecular immunology 47 29400705
2006 Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1. The Journal of biological chemistry 44 16407310
2019 De Novo Variants in TAOK1 Cause Neurodevelopmental Disorders. American journal of human genetics 38 31230721
2021 TAOK1 is associated with neurodevelopmental disorder and essential for neuronal maturation and cortical development. Human mutation 37 33565190
2013 The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma. PloS one 36 23472202
2016 miR-706 inhibits the oxidative stress-induced activation of PKCα/TAOK1 in liver fibrogenesis. Scientific reports 30 27876854
2024 A global phosphosite-correlated network map of Thousand And One Kinase 1 (TAOK1). The international journal of biochemistry & cell biology 25 38479581
2017 Arabidopsis MAP3K16 and Other Salt-Inducible MAP3Ks Regulate ABA Response Redundantly. Molecules and cells 20 28292003
2023 Corylifol A ameliorates muscle atrophy by inhibiting TAOK1/p38-MAPK/FoxO3 pathway in cancer cachexia. Journal of cachexia, sarcopenia and muscle 19 37439183
2022 Inherited and de novo variants extend the etiology of TAOK1-associated neurodevelopmental disorder. Cold Spring Harbor molecular case studies 16 35091509
2021 Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach. Journal of enzyme inhibition and medicinal chemistry 16 33167727
2023 Neurodevelopmental disorder-associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase. Science signaling 12 36595571
2022 TAOK1 Promotes Proliferation and Invasion of Non-Small-Cell Lung Cancer Cells by Inhibition of WWC1. Computational and mathematical methods in medicine 12 36158126
2020 TAOK1 positively regulates TLR4-induced inflammatory responses by promoting ERK1/2 activation in macrophages. Molecular immunology 12 32344244
2023 Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic rewiring. Hepatology communications 11 36930872
1984 Construction of plasmid vectors from Streptomyces kasugaensis plasmids, pSK1 and pSK2. The Journal of antibiotics 11 6094413
2023 Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus. Cell reports 7 37656623
2024 Targeting TAOK1 with resveratrol inhibits esophageal squamous cell carcinoma growth in vitro and in vivo. Molecular carcinogenesis 5 38376345
2024 Expanding the phenotype and genotype spectrum of TAOK1 neurodevelopmental disorder and delineating TAOK2 neurodevelopmental disorder. Genetics in medicine : official journal of the American College of Medical Genetics 5 39737487
2011 PSK2 coordinates glucose metabolism and utilization to maintain ultradian clock-coupled respiratory oscillation in Saccharomyces cerevisiae yeast. Archives of biochemistry and biophysics 5 21345330
2024 lincRNA00907 promotes NASH progression by targeting miRNA-942-5p/TAOK1. Aging 4 38613803
2024 The long noncoding RNA ELFN1-AS1 promotes gastric cancer growth and metastasis by interacting with TAOK1 to inhibit the Hippo signaling pathway. Cell death discovery 4 39528458
2024 TAOK1-mediated regulation of the YAP/TEAD pathway as a potential therapeutic target in heart failure. PloS one 3 39121041
2021 MiR-200c-3p affects cochlear hair cells damaged by oxidative stress via modulating Taok1 expression. American journal of translational research 3 35035705
2015 Identification of Psk2, Skp1, and Tub4 as trans-acting factors for uORF-containing ROK1 mRNA in Saccharomyces cerevisiae. Journal of microbiology (Seoul, Korea) 3 26310304
2024 Heterozygous truncating variant of TAOK1 in a boy with periventricular nodular heterotopia: a case report and literature review of TAOK1-related neurodevelopmental disorders. BMC medical genomics 2 38443934
2023 Ste20-Like Kinase TAOK1 Positively Regulates Antiviral Responses by Controlling the TBK1-IRF3 Signaling Axis. Journal of innate immunity 2 36649698
2023 Activity-dependent membrane sculpting deficits in TAOK1-linked neurodevelopmental disease. Trends in neurosciences 2 37230852
2022 [The role and mechanism of lncRNA C9ORF139 targeting miR-24-3P/TAOK1 in regulating the proliferation of acute myeloid leukemia cells]. Zhonghua yi xue za zhi 2 35196780
2025 TAOK1 promotes filament formation in HR repair through phosphorylating USP7. Proceedings of the National Academy of Sciences of the United States of America 1 40106350
2025 Shenling Baizhu Powder and Betulin attenuate sepsis-induced intestinal injury by targeting GADD45B/TAOK1/p38 MAPK pathway. Journal of ethnopharmacology 1 40653040
2025 LncRNA C9orf139 Promotes Acute Myeloid Leukemia Cell Proliferation by Sponging miR-24-3p to Upregulate TAOK1. Current medical science 1 41296255
2024 Protective Role of TAOK1-CDC20 Axis in Atherosclerosis: Modulation of Endothelial Apoptosis and Senescence. Discovery medicine 1 39726311
2023 Isolation and characterization of vB_SenS_Ib_psk2 bacteriophage against drug-resistant Salmonella enterica serovar Kentucky. Folia microbiologica 1 37074624
2026 PAD4+ neutrophils promote hepatic stellate cell activation and accelerate MASH fibrosis progression viaNET-DNA/TAOK1/MAPK pathways. JCI insight 0 41480748
2026 Discovery of VU6083859, a TAOK1 Selective Inhibitor, and VU6080195, a pan-TAOK Activator. ACS chemical neuroscience 0 41530942
2025 Deferasirox Targets TAOK1 to Induce p53-Mediated Apoptosis in Esophageal Squamous Cell Carcinoma. International journal of molecular sciences 0 40003990
2025 The potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy. Pharmacological research 0 40339965
2025 Schip1 promotes osteoclast differentiation via Taok1-mediated activation of the p38 MAPK signaling pathway in mouse models of osteoporosis. Bone 0 40633827
2025 Corylifol A ameliorates pancreatic cancer-associated cachexia by targeting TAOK3 in pancreatic cancer cells and targeting TAOK1 in skeletal muscle cells. Toxicology and applied pharmacology 0 41110813
2025 LINC01198 activates Hippo signaling to stimulate IL-1β autocrine for driving vemurafenib resistance by associating with TAOK1/2 in melanoma. Cell death discovery 0 41145465