Affinage

TAF8

Transcription initiation factor TFIID subunit 8 · UniProt Q7Z7C8

Round 2 corrected
Length
310 aa
Mass
34.3 kDa
Annotated
2026-04-28
128 papers in source corpus 8 papers cited in narrative 8 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TAF8 is an integral subunit of the general transcription factor TFIID that plays a central scaffolding role in TFIID assembly, nuclear import of partner subunits, and transcription initiation at RNA polymerase II promoters. Through its histone fold domain, TAF8 forms a non-canonical heterodimer with TAF10 and nucleates a cytoplasmic TAF2–TAF8–TAF10 trimeric submodule whose assembly is a prerequisite for TAF2 incorporation into nuclear core-TFIID; binding of the TAF8–TAF10 heterodimer breaks the two-fold symmetry of core-TFIID, generating the asymmetric architecture required for holo-TFIID maturation (PMID:25586196, PMID:23292512, PMID:27007846). TAF8 provides the nuclear localization signal essential for TAF10 nuclear import and interacts with TFIIA to relieve TAF250-mediated repression of TBP on core promoters (PMID:15870280, PMID:11564872). Loss of the mouse ortholog (taube nuss) causes apoptosis of inner cell mass cells by E4.0, and TAF8 is selectively induced during adipogenesis where its histone fold domain is required for 3T3-L1 differentiation (PMID:11076765, PMID:14580349).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 2000 High

    Establishing that the Tbn/TAF8 locus is essential in early mammalian development resolved whether TFIID subunits beyond TBP have non-redundant roles in vivo: Tbn-null embryos showed specific apoptosis of inner cell mass cells while trophoblast survived, demonstrating a cell-type-selective requirement for TAF8 in pluripotent cell survival.

    Evidence Gene knockout in mouse with TUNEL and caspase-3 immunostaining of blastocysts

    PMID:11076765

    Open questions at the time
    • Downstream transcriptional targets whose loss triggers apoptosis are unknown
    • Whether TAF8 has TFIID-independent functions in ICM survival was not addressed
  2. 2001 High

    Determining how TAF8 contributes to promoter recognition showed that it pairs with TAF10 (H2B-like) in a histone-fold interaction critical for TFIID assembly and cooperates with TFIIA to relieve TAF250-mediated repression of TBP, linking TAF8 to a specific activation step in preinitiation complex formation.

    Evidence Far-Western interaction mapping, in vitro TFIID assembly, and functional transcription assays

    PMID:11564872

    Open questions at the time
    • The structural basis of TFIIA–TAF8 cooperation was not resolved
    • Relevance of TAF250 repression relief at native promoters in vivo was not tested
  3. 2003 High

    Identifying TAF8 as the human ortholog of mouse TBN and showing its dramatic induction during adipogenesis established that a core TFIID subunit is subject to lineage-specific regulation; dominant-negative HFD expression specifically blocked adipocyte differentiation, demonstrating a functional requirement.

    Evidence Co-IP from endogenous TFIID, Western blot during 3T3-L1 differentiation, ectopic expression of HFD dominant-negative

    PMID:14580349

    Open questions at the time
    • Adipogenic target genes directly regulated by TAF8-containing TFIID were not identified
    • Whether TAF8 induction is driven by PPARγ or C/EBP cascades was not determined
  4. 2005 High

    Demonstrating that TAF10 lacks an intrinsic NLS and depends on TAF8 for nuclear import revealed a regulated cytoplasmic-to-nuclear transport step in TFIID biogenesis, with the TAF8 NLS shown to be both necessary and sufficient for importin-β-mediated co-translocation.

    Evidence Fluorescent fusion protein localization, NLS mutagenesis, importin-β binding assay, FRAP, leptomycin B treatment

    PMID:15870280

    Open questions at the time
    • Whether additional cargo adaptors modulate TAF8–TAF10 import kinetics is unknown
    • Regulation of TAF8 NLS accessibility was not explored
  5. 2007 High

    Showing that TAF8 is shared between TFIID and a distinct SMAT complex (TAF8–TAF10–SPT7L) and is absolutely required for TAF10 integration into the seven-TAF core TFIID established TAF8 as a gatekeeper of TFIID subunit composition.

    Evidence Co-IP, in vitro binding, proteomic analysis, and complex reconstitution

    PMID:17375202

    Open questions at the time
    • Functional role of SMAT distinct from TFIID remains undefined
    • Whether SPT7L and TFIID compete for TAF8 in vivo was not measured
  6. 2013 High

    Cryo-EM of reconstituted core-TFIID showed that TAF8–TAF10 binding breaks the intrinsic two-fold symmetry of the five-TAF core, explaining how a single copy of this heterodimer generates the asymmetric scaffold needed for holo-TFIID assembly.

    Evidence Cryo-EM at 11.6 Å resolution of reconstituted core-TFIID ± TAF8–TAF10

    PMID:23292512

    Open questions at the time
    • Atomic-resolution contacts mediating symmetry breaking were not resolved at this resolution
    • Order of subsequent lobe-specific TAF additions was not defined
  7. 2015 High

    X-ray crystallography of the TAF8–TAF10 histone fold heterodimer revealed a non-canonical fold arrangement, and native mass spectrometry defined the cytoplasmic TAF2–TAF8–TAF10 trimer as the import-competent module, with TAF8's C-terminal region essential for TAF2 recruitment into nuclear TFIID.

    Evidence X-ray crystallography, native mass spectrometry, co-IP, biochemical reconstitution

    PMID:25586196

    Open questions at the time
    • Whether additional chaperones facilitate cytoplasmic trimer assembly is unknown
    • Structural basis of TAF8 C-terminus–TAF2 interaction at atomic resolution was not obtained
  8. 2016 High

    Sub-nanometre cryo-EM of promoter-bound TFIID–TFIIA placed the TAF8–TAF10 module within lobe B, directly linking the symmetry-breaking subunit to the promoter-contacting surface and establishing its architectural contribution to the functional preinitiation complex.

    Evidence Single-particle cryo-EM of TFIID–TFIIA–DNA complex

    PMID:27007846

    Open questions at the time
    • Direct DNA contacts by TAF8 itself were not resolved
    • Whether TAF8 occupancy changes at different promoter classes is unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the genome-wide identification of TAF8-dependent target genes, the structural basis by which TAF8 cooperates with TFIIA to relieve TBP repression, and the physiological significance of the SMAT complex versus TFIID.
  • No ChIP-seq or genomic occupancy data for TAF8 described in the timeline
  • Atomic-resolution structure of TAF8 within complete holo-TFIID on DNA not yet available
  • Functional distinction of SMAT versus TFIID in transcription regulation remains undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140223 general transcription initiation factor activity 3 GO:0005198 structural molecule activity 2 GO:0042393 histone binding 2
Localization
GO:0005634 nucleus 2 GO:0005829 cytosol 2
Pathway
R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1266738 Developmental Biology 1
Partners
SPT7LTAF10TAF2TAF250TFIIA
Complex memberships
SMAT (TAF8–TAF10–SPT7L)TAF2–TAF8–TAF10 cytoplasmic trimerTFIID

Evidence

Reading pass · 8 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 Human TAF8 (TAF(II)43) is an integral component of functional TFIID and is the apparent ortholog of mouse TBN (taube nuss). TAF8 expression is dramatically induced and sequestered within TFIID upon differentiation of 3T3-L1 preadipocytes to adipocytes, while expression of all other tested TAFs is slightly reduced. Ectopic expression of the histone fold domain (HFD) of TAF8 acts as a dominant-negative mutant and selectively inhibits 3T3-L1 adipogenic differentiation, whereas full-length TAF8 acts as a positive regulator of adipogenesis. Co-immunoprecipitation, Western blotting, ectopic expression/dominant-negative mutant analysis, 3T3-L1 differentiation assay Molecular cell High 14580349
2000 The mouse Tbn gene (encoding TBN/TAF8) is essential for survival of inner cell mass (ICM) cells in early mouse embryos. Tbn mutant embryos develop to blastocyst stage but ICM cells undergo apoptosis (TUNEL-positive, caspase-3 activation) by E4.0, while trophoblast cells remain viable, demonstrating a specific requirement for TBN in pluripotent cell survival. Gene knockout (homologous recombination), TUNEL assay, immunostaining for caspase-3, in vitro ICM culture Development (Cambridge, England) High 11076765
2001 Human TAF(II)135 (later designated TAF8 ortholog in nomenclature context) interacts strongly with TAF(II)20/hTAF20 (histone H2B-like) and moderately with TAF(II)150, consistent with a histone H2A–H2B-like pairing. The TAF(II)20–TAF(II)135 interaction is critical for human TFIID assembly in vitro. TAF(II)135 also interacts directly with hTFIIA and cooperates with TFIIA to relieve TAF(II)250-mediated repression of TBP binding on core promoters. Far-Western blot, in vitro TFIID assembly assay, functional transcription assays Molecular and cellular biology High 11564872
2007 TAF8 is a subunit of both TFIID and a small TAF complex (SMAT) containing TAF8, TAF10, and SPT7L. TAF8 is absolutely necessary for integration of TAF10 into a higher-order TFIID core complex containing seven TAFs. TAF8 forms a heterodimer with TAF10 through its histone fold domain (HFD) and proline-rich domain, interacts with SPT7L through its C-terminal region, and all three proteins form a complex both in vitro and in vivo. Co-immunoprecipitation, in vitro binding assays, proteomic analysis, complex reconstitution PloS one High 17375202
2005 TAF8 contains a nuclear localization signal (NLS) that is required for nuclear import of TAF10. TAF10 lacks an intrinsic NLS and depends on interaction with TAF8 (or SPT7L or TAF3) to enter the nucleus. Mutation of the TAF8 NLS retains TAF10 in the cytoplasm. TAF10 binding to importin-β in vitro depends on co-expression of TAF8 (or TAF3). The cytoplasmic-to-nuclear transport of TAF10 is regulated during adult male germ cell differentiation. Fluorescent fusion protein localization, NLS mutagenesis, importin-β binding assay in vitro, FRAP, leptomycin B treatment Molecular and cellular biology High 15870280
2015 TAF8 nucleates a cytoplasmic heterotrimeric subcomplex with TAF2 and TAF10 that assembles prior to nuclear import. Native mass spectrometry defines the interactions: TAF8 interacts centrally with both TAF10 (via histone fold domains in a non-canonical arrangement) and TAF2 (via multiple motifs in TAF8's C-terminal region). TAF2 incorporation into a nuclear core-TFIID complex depends on these TAF8 C-terminal interactions. X-ray crystallography reveals that the TAF8–TAF10 histone fold domain arrangement is non-canonical. Native mass spectrometry, X-ray crystallography of TAF8–TAF10 HFD complex, co-immunoprecipitation, biochemical reconstitution Nature communications High 25586196
2013 Cryo-electron microscopy of human core-TFIID reveals that binding of one TAF8–TAF10 heterodimer breaks the two-fold symmetry of the core-TFIID complex (composed of TAF4, TAF5, TAF6, TAF9, TAF12), generating an asymmetric structure proposed to serve as a scaffold for holo-TFIID assembly. Cryo-electron microscopy (11.6 Å resolution), biochemical reconstitution of core-TFIID Nature High 23292512
2016 Cryo-EM structure of human TFIID bound to TFIIA and core promoter DNA at sub-nanometre resolution shows that TAF8 participates in the overall TFIID architecture and promoter-bound complex; the TAF8–TAF10 module contributes to the asymmetric lobe B structure of TFIID that contacts promoter DNA. Single-particle cryo-electron microscopy, promoter DNA binding assay Nature High 27007846

Source papers

Stage 0 corpus · 128 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2007 Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Cell 707 17884155
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2010 Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell 639 20850016
2011 Human mediator subunit MED26 functions as a docking site for transcription elongation factors. Cell 281 21729782
2016 Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. Nature 193 27007846
2002 A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription. Genes & development 193 11963920
2009 Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. Molecular psychiatry 170 19204726
2021 Brentuximab vedotin in combination with nivolumab in relapsed or refractory Hodgkin lymphoma: 3-year study results. Blood 164 33827139
2017 Structural covariance networks are coupled to expression of genes enriched in supragranular layers of the human cortex. NeuroImage 151 29274746
2018 Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Molecular cell 136 30554943
2017 RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. BMC biology 135 29117863
2004 Protein malnutrition and hypoalbuminemia as predictors of vascular events and mortality in ESRD. American journal of kidney diseases : the official journal of the National Kidney Foundation 133 14712428
2013 The architecture of human general transcription factor TFIID core complex. Nature 127 23292512
2022 Human transcription factor protein interaction networks. Nature communications 123 35140242
2007 Toward a confocal subcellular atlas of the human proteome. Molecular & cellular proteomics : MCP 114 18029348
2019 Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Genes & development 110 31753913
2004 Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression. Molecular cell 104 15053879
2013 Human TFIID binds to core promoter DNA in a reorganized structural state. Cell 102 23332750
2002 Significance of transthyretin in protein metabolism. Clinical chemistry and laboratory medicine 89 12553432
2000 The predictive value of body protein for chemotherapy-induced toxicity. Cancer 82 10679649
2015 Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules. Nature communications 80 25586196
2020 Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Cell reports 79 32814053
2017 Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post-ischaemic neuroregeneration and recovery of neurological functions in rats. British journal of pharmacology 78 29161771
2016 Joint-linkage mapping and GWAS reveal extensive genetic loci that regulate male inflorescence size in maize. Plant biotechnology journal 77 26801971
2019 The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Nature communications 74 31586073
2006 Dried plum prevents bone loss in a male osteoporosis model via IGF-I and the RANK pathway. Bone 73 16890505
2012 Bovine lactoferrin improves bone mass and microstructure in ovariectomized rats via OPG/RANKL/RANK pathway. Acta pharmacologica Sinica 65 22902986
2008 Expression of genes involved in early cell fate decisions in human embryos and their regulation by growth factors. Reproduction (Cambridge, England) 64 18411410
1986 Body composition of two human cadavers by neutron activation and chemical analysis. The American journal of physiology 64 3953790
2008 The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. Molecular and cellular biology 63 19114550
2000 Taube nuss is a novel gene essential for the survival of pluripotent cells of early mouse embryos. Development (Cambridge, England) 61 11076765
2007 STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation. Molecular and cellular biology 60 17967894
2014 The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Human molecular genetics 58 24705354
1983 Indexes of body cell mass: nitrogen versus potassium. The American journal of physiology 55 6829756
2001 Positive and negative TAF(II) functions that suggest a dynamic TFIID structure and elicit synergy with traps in activator-induced transcription. Molecular and cellular biology 54 11564872
2020 Tetramethylpyrazine nitrone improves motor dysfunction and pathological manifestations by activating the PGC-1α/Nrf2/HO-1 pathway in ALS mice. Neuropharmacology 47 33152451
2017 Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia. Neuropharmacology 47 28342896
2007 Identification of a small TAF complex and its role in the assembly of TAF-containing complexes. PloS one 47 17375202
2005 The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners. Molecular and cellular biology 45 15870280
2017 Architecture of TAF11/TAF13/TBP complex suggests novel regulation properties of general transcription factor TFIID. eLife 42 29111974
1996 Changes in body composition of human immunodeficiency virus-infected males receiving insulin-like growth factor I and growth hormone. The Journal of clinical endocrinology and metabolism 39 8768870
2007 Soy isoflavones avert chronic inflammation-induced bone loss and vascular disease. Journal of inflammation (London, England) 38 17825101
2018 Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy. Neuromolecular medicine 36 29411248
2014 Involvement of telomerase reverse transcriptase in heterochromatin maintenance. Molecular and cellular biology 35 24550003
2023 Targeted therapy with nanatinostat and valganciclovir in recurrent EBV-positive lymphoid malignancies: a phase 1b/2 study. Blood advances 34 37530631
2006 Influence of growth conditions on the production of extracellular proteolytic enzymes in Paenibacillus peoriae NRRL BD-62 and Paenibacillus polymyxa SCE2. Letters in applied microbiology 33 17083708
2003 The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Molecular cell 33 14580349
2013 A comparative study of the bone metabolic response to dried plum supplementation and PTH treatment in adult, osteopenic ovariectomized rat. Bone 32 24125756
2016 Tetramethylpyrazine Nitrone Improves Neurobehavioral Functions and Confers Neuroprotection on Rats with Traumatic Brain Injury. Neurochemical research 31 27452038
2013 Lean mass as a predictor of bone density and microarchitecture in adult obese individuals with metabolic syndrome. Bone 31 24220493
2013 In vitro evaluation on neutral detergent fiber and cellulose digestion by post-ruminal microorganisms in goats. Journal of the science of food and agriculture 31 24254250
1988 One-year follow-up of weight, total body potassium, and total body nitrogen in obese adolescents treated with the protein-sparing modified fast. The American journal of clinical nutrition 31 3389334
2014 Partial loss of Smad7 function impairs bone remodeling, osteogenesis and enhances osteoclastogenesis in mice. Bone 29 24998669
2016 Targeted nanoconjugate co-delivering siRNA and tyrosine kinase inhibitor to KRAS mutant NSCLC dissociates GAB1-SHP2 post oncogene knockdown. Scientific reports 27 27530552
1997 Massive nitrogen loss in critical surgical illness: effect on cardiac mass and function. Annals of surgery 27 9296513
2010 Agreement, precision, and accuracy of epifluorescence microscopy methods for enumeration of total bacterial numbers. Applied and environmental microbiology 26 20097826
2005 Effect of the polymorphism of prolactin receptor (PRLR) and leptin (LEP) genes on litter size in Polish pigs. Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie 24 16274424
2019 Tetramethylpyrazine Nitrone Reduces Oxidative Stress to Alleviate Cerebral Vasospasm in Experimental Subarachnoid Hemorrhage Models. Neuromolecular medicine 23 31134485
1998 Relationship of body water compartments to age, race, and fat-free mass. The Journal of laboratory and clinical medicine 22 9851738
2017 Tetramethylpyrazine nitrone protects retinal ganglion cells against N-methyl-d-aspartate-induced excitotoxicity. Journal of neurochemistry 21 28160291
1982 Changes in body protein, body potassium, and lean body mass during total parenteral nutrition. JPEN. Journal of parenteral and enteral nutrition 21 6808168
2023 Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 pathway in Parkinson's disease models. Journal of advanced research 20 37989471
2018 Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090. Microbial cell factories 20 30153835
2021 TBN improves motor function and prolongs survival in a TDP-43M337V mouse model of ALS. Human molecular genetics 19 33929499
2020 Telomerase Biology Associations Offer Keys to Cancer and Aging Therapeutics. Current aging science 18 31544708
2017 Deficiency of DGCR8 increases bone formation through downregulation of miR-22 expression. Bone 18 28739418
2010 Mild hyperoxia limits hTR levels, telomerase activity, and telomere length maintenance in hTERT-transduced bone marrow endothelial cells. Biochimica et biophysica acta 18 20619302
2018 The phytoestrogen genistein prevents trabecular bone loss and affects thyroid follicular cells in a male rat model of osteoporosis. Journal of anatomy 17 29761487
2010 In vitro and in vivo multidrug resistance reversal activity by a Betti-base derivative of tylosin. British journal of cancer 17 20551959
2023 Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer's disease mouse model and proteomics analysis. Frontiers in pharmacology 16 36950017
2000 Total body protein in chronic diseases and in aging. Annals of the New York Academy of Sciences 16 10865769
1994 Total body nitrogen in children with chronic renal failure and short stature. European journal of clinical nutrition 16 7925226
2024 Visible-Light-Promoted α-C(sp3)-H Amination of Ethers with Azoles and Amides. Organic letters 15 38241172
2019 Combination of multi-locus genome-wide association study and QTL mapping reveals genetic basis of tassel architecture in maize. Molecular genetics and genomics : MGG 15 31289944
2015 A proteomic analysis of seeds from Bt-transgenic Brassica napus and hybrids with wild B. juncea. Scientific reports 15 26486652
2021 QDtbn1 , an F-box gene affecting maize tassel branch number by a dominant model. Plant biotechnology journal 14 33382512
1993 In vivo animal models of body composition in aging. The Journal of nutrition 14 8429404
2015 Cysteine induces longitudinal bone growth in mice by upregulating IGF-I. International journal of molecular medicine 13 26101100
2007 Total body protein in healthy adolescent girls: validation of estimates derived from simpler measures with neutron activation analysis. The American journal of clinical nutrition 12 17209179
1988 Comparison of afferent and efferent lung lymph in the sheep. Journal of applied physiology (Bethesda, Md. : 1985) 12 3403418
2020 Establishment and characterization of a cold-sensitive neural cell line from the brain of tilapia (Oreochromis niloticus). Journal of fish biology 11 33258111
2017 Effects of pulsed electromagnetic fields on histomorphometry and osteocalcin in disuse osteoporosis rats. Technology and health care : official journal of the European Society for Engineering and Medicine 11 28582887
2024 Tetramethylpyrazine Nitrone alleviates D-galactose-induced murine skeletal muscle aging and motor deficits by activating the AMPK signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 10 38479182
2019 Thromboxane-prostaglandin receptor antagonist, terutroban, prevents neurovascular events after subarachnoid haemorrhage: a nanoSPECT study in rats. Critical care (London, England) 10 30744667
2024 Identification of Microorganism in Infected Wounds by Positively Charged Selective Sensor Array and Deep Learning Algorithm. Analytical chemistry 9 38702857
1996 A neutron activation analysis facility for in vivo measurement of nitrogen and chlorine in children. Australasian physical & engineering sciences in medicine 9 9060212
1995 Application of the associated particle technique for the whole-body measurement of protein, fat and water by 14 MeV neutron activation analysis--a feasibility study. Physics in medicine and biology 9 7659729
1987 Body composition of fasting obese patients measured by in vivo neutron activation analysis and isotopic dilution. Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics 9 3304806
2015 Seagrass vegetation and meiofauna enhance the bacterial abundance in the Baltic Sea sediments (Puck Bay). Environmental science and pollution research international 8 26178839
2024 Tetramethylpyrazine nitrone delays the aging process of C. elegans by improving mitochondrial function through the AMPK/mTORC1 signaling pathway. Biochemical and biophysical research communications 7 38850811
2022 Genetic Variation in ZmPAT7 Contributes to Tassel Branch Number in Maize. International journal of molecular sciences 7 35269730
2020 Phase I safety, tolerability, and pharmacokinetic studies of tetramethylpyrazine nitrone in healthy Chinese volunteers. Drug development research 7 32864754
2024 Tetramethylpyrazine Nitrone (TBN) Reduces Amyloid β Deposition in Alzheimer's Disease Models by Modulating APP Expression, BACE1 Activity, and Autophagy Pathways. Pharmaceuticals (Basel, Switzerland) 6 39204110
2023 ZmELF3.1 integrates the RA2-TSH4 module to repress maize tassel branching. The New phytologist 6 37858961
2019 Comparison of bone biomechanical properties after bone marrow mesenchymal stem cell or alendronate treatment in an osteoporotic animal model. Biomedizinische Technik. Biomedical engineering 6 31116701
2023 Genome-wide analysis of R2R3-MYB genes in cultivated peanut (Arachis hypogaea L.): Gene duplications, functional conservation, and diversification. Frontiers in plant science 5 36866371
2022 Tetramethylpyrazine nitrone TBN extends the lifespan of C. elegans by activating the Nrf2/SKN-1 signaling pathway. Biochemical and biophysical research communications 5 35576681
2022 Tetramethylpyrazine nitrone activates hypoxia-inducible factor and regulates iron homeostasis to improve renal anemia. Frontiers in pharmacology 5 36324690
2025 A long term bone and renal safety of TAF treatment on renal transplant recipients. Biomedical journal 4 39956376
2025 Visible-Light-Induced Difunctionalization of Styrenes with Aryl Hydrazines and tert-Butyl Nitrite: One-Pot Access to α-Arylethanone Oximes. Organic letters 4 40987563
2020 A Novel Peptide, CK2.3, Improved Bone Formation in Ovariectomized Sprague Dawley Rats. International journal of molecular sciences 4 32664215
2014 Suppression of IL-2 production and proliferation of CD4(+) T cells by tuberostemonine O. Chemistry & biodiversity 4 25491339
2007 [Identification of QTL associated with tassel branch number and total tassel length in maize]. Yi chuan = Hereditas 4 17681933
2000 Leydig cell hyperplasia and the maintenance of bone volume: bone histomorphometry and testicular histopathology in 29 male leprosy autopsy cases. International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 4 11221087
2025 tBN-CSDI: a time-varying blue noise-based diffusion model for time-series imputation. Bioinformatics advances 3 41127882
2024 Dirac t-Boron Nitride Monolayer as an Appealing Binder-Free Anode for Alkali Metal Ion Batteries. Langmuir : the ACS journal of surfaces and colloids 3 38166436
2024 Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin-Proteasome System Activation. Neuromolecular medicine 3 38568291
2023 Identification of QTLs and their candidate genes for the number of maize tassel branches in F2 from two higher generation sister lines using QTL mapping and RNA-seq analysis. Frontiers in plant science 3 37641589
1998 High level accumulation of an aberrantly spliced human DHFR RNA species. Molecules and cells 3 9638651
2023 Acute hypoxia attenuates resistance exercise-induced ribosome signaling but does not impact satellite cell pool expansion in human skeletal muscle. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2 36786723
2026 Photocatalyst-free access to α-arylethanone oximes enabled by sequential HAT/SET of aryl iodides with TBN and alkenes. Chemical communications (Cambridge, England) 1 41493369
2025 Enhanced separation performance and biocompatibility of polyethersulfone hollow fiber membranes using titanium diboride derived nanomaterial and gel coating for biomedical applications. Colloids and surfaces. B, Biointerfaces 1 41352161
2023 Biocompatibility and Osseointegration of the Biomimetically Coated and Water-Soluble Eggshell Membrane Protein Cross-Linked Ti Alloy Screws. Iranian biomedical journal 1 38477251
2020 Fine mapping and candidate gene prediction of a major quantitative trait locus for tassel branch number in maize. Gene 1 32622989
2011 S-nitrosocaptopril formation in aqueous acid and basic medium. A vasodilator and angiotensin converting enzyme inhibitor. Organic & biomolecular chemistry 1 21860877
2026 METTL16 Modulates GPX4 Expression to Regulate Chondrocyte Ferroptosis. Frontiers in bioscience (Landmark edition) 0 41761981
2025 Pharmacochemical Studies of Synthesized Coumarin-Isoxazole-Pyridine Hybrids. Molecules (Basel, Switzerland) 0 40286200
2025 Photoelectrochemical Catalyzed Site-Selective Tryptophan β-Position Functionalization. Journal of the American Chemical Society 0 41058170
2025 Tetramethylpyrazine nitrone: a multifaceted neuroprotective agent in neurodegenerative disorders. Neurodegenerative disease management 0 41345047
2025 Extracellular vesicles-derived hybrid biomimetic nanoplatforms camouflaged Golgi apparatus-targeted aggregation induced emission photosensitizer to elicit pyroptosis and immunogenic cell death for efficient antitumor photoimmunotherapy. Acta pharmaceutica Sinica. B 0 41909726
2024 Paraburkholderia tropica Primes a Multilayered Transcriptional Defense Response to the Nematode Meloidogyne spp. in Tomato. International journal of molecular sciences 0 39684296
1989 Effect of histamine on tracheobronchial afferent and caudal mediastinal efferent lymph. Experimental lung research 0 2707181