Affinage

STRA8

Stimulated by retinoic acid gene 8 protein homolog · UniProt Q7Z7C7

Length
330 aa
Mass
36.9 kDa
Annotated
2026-06-10
55 papers in source corpus 18 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

STRA8 is a retinoic acid-induced, nucleocytoplasmic shuttling transcriptional regulator that serves as the central gatekeeper of the mitosis-to-meiosis transition in both male and female germ cells (PMID:18799751, PMID:19805549). Genetic loss in mice abolishes meiotic prophase hallmarks—chromosome cohesion, synapsis, and recombination—while leaving early mitotic germ cell development intact, establishing STRA8 as required not for meiotic initiation per se but for stable commitment to the meiotic cell cycle: Stra8-null leptotene spermatocytes complete premeiotic DNA replication yet undergo premature chromosome condensation into aberrant univalent-bearing metaphase-like cells (PMID:18799751, PMID:18799790). STRA8 shuttles between cytoplasm and nucleus through an N-terminal basic NLS and an XPO1-recognized NES, and once nuclear it binds DNA and carries intrinsic transcriptional activity (PMID:19805549). It couples meiotic entry to the cell cycle by binding RB through an LXCXE motif to drive S-phase entry and meiotic gene activation, plausibly by sequestering RB from E2F at the pre-meiotic G1/S transition (PMID:37880249). As a transcriptional effector STRA8 acts bidirectionally: it represses Nr1d1 to restrain a Ulk1-driven autophagy program—a repression whose loss is sufficient to block meiotic initiation (PMID:31059511)—and it mediates the retinoic acid-driven transcriptional progression that promotes spermatogonial differentiation, with Stra8-null germ cells showing a muted RA response that retains undifferentiated-state transcripts (PMID:25902548, PMID:33400349). STRA8 expression is itself tightly controlled at its promoter by retinoic acid acting through defined RAREs and the activator DMRT1, and is repressed by the bHLH factors SOHLH1/2 acting at E-box motifs (PMID:33574039, PMID:21621532, PMID:25603532). Beyond the germline, STRA8 is induced by neuronal activity in adult brain, where it represses neuromodulator genes such as Npas4 and is required for neuronal proteostasis, plasticity, and circuit function (PMID:41187062).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1996 High

    Established STRA8 as a discrete, retinoic acid-regulated protein with defined biochemical properties, setting the stage for functional study of an RA-responsive germ cell factor.

    Evidence Subcellular fractionation, 2D gel, and dephosphorylation assays in premeiotic germ cells

    PMID:8896602

    Open questions at the time
    • Function entirely unknown at this stage
    • Significance of phosphorylation forms not resolved
    • No DNA-binding or transcriptional activity yet demonstrated
  2. 2008 High

    Defined STRA8 as essential for meiotic commitment in both sexes, distinguishing its requirement for stable entry into the meiotic cell cycle from the initiation of meiotic events themselves.

    Evidence Stra8-null mice with histology, meiotic marker immunofluorescence, and chromosome analysis

    PMID:18799751 PMID:18799790

    Open questions at the time
    • Molecular targets of STRA8 not identified
    • Mechanism coupling STRA8 to cell-cycle control unknown
    • Direct DNA targets undefined
  3. 2009 High

    Showed STRA8 is a regulated nucleocytoplasmic shuttling protein that binds DNA and drives transcription, reframing it from a cytoplasmic protein to a candidate transcription factor.

    Evidence NLS/NES domain mutagenesis, LMB treatment, DNA-binding and reporter assays in transfected cells

    PMID:19805549

    Open questions at the time
    • Endogenous DNA target genes not identified
    • Triggers of nuclear import in germ cells unknown
    • Structural basis of DNA binding undefined
  4. 2011 High

    Identified DMRT1 as a direct, sex-specific transcriptional activator of Stra8, explaining how upstream sexual-fate regulators feed into meiotic timing.

    Evidence Genome-wide ChIP-chip, qChIP, and Dmrt1-null fetal ovary analysis

    PMID:21621532

    Open questions at the time
    • Mechanism of sex-specific switch (activation vs repression) unresolved
    • Cofactors at the Stra8 locus undefined
  5. 2013 Medium

    Resolved opposing roles of CBP and p300 in RA-mediated Stra8 transcription, refining the co-activator architecture controlling Stra8 induction.

    Evidence shRNA knockdown, overexpression, ChIP for histone acetylation and Pol II, luciferase assays in mES cells

    PMID:23785470

    Open questions at the time
    • HAT-independent p300 repression mechanism unexplained
    • Single lab, not in germ cells in vivo
  6. 2015 High

    Showed SOHLH1/SOHLH2 directly repress Stra8 at E-box motifs and that STRA8 additionally promotes spermatogonial differentiation, broadening its role beyond meiotic initiation.

    Evidence E-box mutagenesis with gain/loss-of-function in cell lines and spermatogonia; Stra8-null mice with RA injection and cell-stage quantification

    PMID:25603532 PMID:25902548

    Open questions at the time
    • How a single factor switches between differentiation and meiotic-entry outputs unresolved
    • Direct STRA8 differentiation targets not yet defined
  7. 2016 Medium

    Established STRA8, with SMAD4, as a determinant of female germ cell fate, placing it in the germline sexual-differentiation network.

    Evidence Smad4/Stra8 double conditional knockout with ovary transcriptome analysis

    PMID:27606421

    Open questions at the time
    • Direct molecular link between STRA8 and SMAD4 not shown
    • Whether STRA8 acts upstream or in parallel to SMAD4 unclear
  8. 2019 High

    Identified the first direct repressive target of STRA8 (Nr1d1) and a complete pathway linking STRA8 to autophagy suppression required for meiotic initiation.

    Evidence Stra8-KO mice, ChIP at Nr1d1/Ulk1 promoters, Nr1d1 deletion and pharmacologic rescue, autophagy assays

    PMID:31059511

    Open questions at the time
    • Whether autophagy repression fully accounts for the meiotic phenotype unresolved
    • Other direct STRA8 targets not catalogued
  9. 2020 Medium

    Defined STRA8 protein-interaction modules—SETD8 and bHLH factors (TCF3/E47, SOHLH1) via its HLH domain—showing STRA8 can homodimerize and antagonize E-box-dependent transcription.

    Evidence Yeast two-hybrid, Co-IP with domain mapping, reporter assays, and testis immunofluorescence

    PMID:32090428 PMID:33236849

    Open questions at the time
    • Single lab; reciprocal in vivo validation limited
    • Functional consequence of SETD8/H4K20me1 co-localization not genetically tested
    • Direct DNA-binding vs cofactor sequestration roles not separated
  10. 2021 High

    Mapped STRA8 as the transducer of the RA transcriptional program in spermatogonia and defined the RARE/DMRT1 architecture of its promoter in vivo.

    Evidence RNA-seq in WT vs Stra8-KO at multiple RA timepoints, germ cell culture/transplantation, transgenic reporter and CRISPR RARE mutation in vivo

    PMID:33400349 PMID:33574039 PMID:33959758

    Open questions at the time
    • Which transcriptional changes are direct STRA8 targets vs secondary not fully resolved
    • Tcerg1l mechanism downstream of STRA8 undefined
  11. 2023 High

    Connected STRA8 mechanistically to the cell cycle via an RB-binding LXCXE motif required for S-phase entry, and defined an ancestral H3K27me3 chromatin mechanism gating Stra8 expression.

    Evidence LXCXE knock-in mice with scRNA-seq and oocyte quantification; cross-species ChIP-seq and ex vivo H3K27me3 demethylase inhibition

    PMID:36866926 PMID:37880249

    Open questions at the time
    • Direct demonstration of RB-E2F displacement by STRA8 not shown
    • How STRA8 integrates DNA binding with RB sequestration unresolved
  12. 2025 Medium

    Revealed an unanticipated somatic role for STRA8 in adult neurons, where activity-induced STRA8 represses neuromodulator genes and maintains neuronal integrity, extending its transcriptional-repressor function beyond the germline.

    Evidence Neuron-specific Stra8 KO with electrophysiology, ChIP, behavioral tests, and NMDA/calcium pharmacology

    PMID:41187062

    Open questions at the time
    • Single lab, novel finding outside germline
    • Relationship between germline and neuronal STRA8 regulatory programs unknown
    • Whether neuronal STRA8 uses the same RB/cell-cycle logic untested
  13. 2025 Low

    Placed STRA8 within a broader meiotic-entry network as a partner of MEIOSIN and downstream of NFYA-mediated chromatin accessibility and MEIOC feedback.

    Evidence Meioc-null oogenic transcriptomics and Nfya conditional KO with spatial/single-cell ATAC-seq (preprints)

    Open questions at the time
    • Both preprints, not peer-reviewed
    • Direct STRA8-MEIOSIN biochemical interaction not confirmed in these timeline entries
    • NFYA-to-STRA8 target relationship inferred from accessibility, not direct binding

Open questions

Synthesis pass · forward-looking unresolved questions
  • The genome-wide direct DNA target repertoire of STRA8 and the structural basis by which it integrates DNA binding, bHLH antagonism, and RB sequestration into a single meiotic-commitment decision remain undefined.
  • No comprehensive direct target map across germline and neuronal contexts
  • No structural model of the DNA-binding/HLH/LXCXE domains
  • Mechanism switching STRA8 between activator and repressor functions unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003677 DNA binding 3 GO:0140110 transcription regulator activity 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005829 cytosol 2 GO:0005634 nucleus 1
Pathway
R-HSA-1474165 Reproduction 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1640170 Cell Cycle 2
Partners
CBPDMRT1RB1SETD8SMAD4SOHLH1TCF3
Complex memberships
STRA8-MEIOSIN

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 STRA8 encodes a 45-kDa cytoplasmic protein that is phosphorylated in multiple forms; all-trans and 9-cis retinoic acid differentially regulate its phosphorylation status. Subcellular fractionation and immunocytochemistry confirmed cytoplasmic localization in premeiotic germ cells. Subcellular fractionation, immunocytochemistry, 2D gel analysis, dephosphorylation assays The Journal of cell biology High 8896602
2008 STRA8 is required for meiotic initiation in both male and female germ lines in mice; loss of Stra8 in juvenile C57BL/6 males results in failure of meiotic prophase morphology and absence of molecular hallmarks of meiotic chromosome cohesion, synapsis, and recombination, while early mitotic germ cell development is undisturbed. Retinoic acid induces Stra8 to initiate meiosis in both sexes. Genetic knockout (Stra8-null mice), histology, immunofluorescence for meiotic markers Proceedings of the National Academy of Sciences of the United States of America High 18799751
2008 In Stra8-null male mice, spermatocytes initiate recombination and axial-element assembly and undergo premeiotic DNA replication, but most leptotene spermatocytes undergo premature chromosome condensation within 24 hours of meiotic S phase, yielding aberrant metaphase-like cells with 40 univalent chromosomes; STRA8 is required for stable commitment to the meiotic cell cycle rather than for meiotic initiation per se. Stra8-null mouse analysis, cytology, immunostaining for meiotic markers (SPO11, SYCP3), chromosome analysis Journal of cell science High 18799790
2009 STRA8 shuttles between nucleus and cytoplasm via an N-terminal basic nuclear localization signal (NLS) and an Exportin1 (XPO1)-recognized nuclear export signal (NES); nuclear import is an active process. STRA8 associates with DNA and possesses transcriptional activity in transfected cell lines. Subcellular fractionation, immunocytochemistry, domain mutagenesis (NLS/NES deletion), XPO1 inhibitor (LMB) treatment, DNA-binding assay, transcriptional reporter assay in transfected cells The Journal of biological chemistry High 19805549
2011 DMRT1 directly activates Stra8 transcription in fetal ovarian germ cells; genome-wide ChIP-chip and qChIP show DMRT1 binding at the Stra8 locus, and Dmrt1-null fetal ovaries show greatly reduced STRA8 expression and meiotic prophase defects. DMRT1 acts sex-specifically: activating Stra8 in the fetal ovary and repressing it in the adult testis. Genome-wide ChIP-chip, quantitative ChIP, mRNA expression profiling, Dmrt1 knockout mouse analysis, immunostaining Developmental biology High 21621532
2013 CBP (CREB-binding protein) is a co-activator required for retinoic acid-mediated Stra8 transcription: CBP knockdown represses Stra8, CBP overexpression enhances it, and ChIP shows CBP binding at the Stra8 promoter with increased histone acetylation and RNA Pol II recruitment. Conversely, p300 acts as a repressor of Stra8: p300 knockdown enhances Stra8 expression and increases CBP occupancy at the Stra8 promoter, independently of p300's HAT activity. Lentiviral shRNA knockdown, overexpression, ChIP for histone acetylation and RNA Pol II, luciferase reporter assay in mouse embryonic stem cells PloS one Medium 23785470
2015 SOHLH1 and SOHLH2 directly and cooperatively repress STRA8 expression by binding to two canonical E-box motifs in the Stra8 promoter, as demonstrated in cell lines and KIT+ spermatogonia in vitro. shRNA knockdown, overexpression, promoter-binding assays, site-directed mutagenesis of E-box motifs, cell line and primary spermatogonia experiments Cell cycle Medium 25603532
2015 Periodic retinoic acid signaling through STRA8 regulates two distinct germ-cell responses: spermatogonial differentiation and meiotic initiation. In Stra8-null mice, undifferentiated spermatogonia accumulate in excess and differentiating spermatogonia are depleted, demonstrating that STRA8 promotes (but is not strictly required for) spermatogonial differentiation in addition to its established role in meiotic initiation. RA injection acts instructively on germ cells to induce precocious differentiation and meiotic initiation independently. Stra8-null genetic mouse model, in vivo RA injection, histology, cell-stage quantification Proceedings of the National Academy of Sciences of the United States of America High 25902548
2016 Combined germline-specific deletion of Smad4 and Stra8 in female germ cells results in upregulation of male gonocyte differentiation genes (Nanos2, PLZF) without global somatic sex reprogramming, demonstrating that STRA8 (together with SMAD4) is an essential determinant of female germ cell fate. Double conditional knockout (Smad4/Stra8), immunohistochemistry, transcriptome analysis of mutant ovaries PLoS biology Medium 27606421
2019 STRA8 functions as a transcriptional repressor of Nr1d1 by binding to its promoter; Nr1d1 upregulation in Stra8-deficient testes leads to increased Ulk1 expression and autophagy activation. Genetic deletion of Nr1d1 or pharmacologic inhibition of NR1D1 rescues meiotic initiation defects in Stra8-deficient male germ cells. Ectopic STRA8 expression alone is sufficient to inhibit autophagy induction and maturation. Stra8 knockout mice, ChIP (STRA8 at Nr1d1 promoter; NR1D1 at Ulk1 promoter), Nr1d1 genetic deletion, pharmacologic NR1D1 inhibition (SR8278), autophagy assays, biochemical overexpression PLoS genetics High 31059511
2020 STRA8 physically interacts with SETD8 (a histone methyltransferase); interaction was identified by yeast two-hybrid and confirmed by co-immunoprecipitation with key domain mapping. SETD8 negatively regulates STRA8 promoter transcriptional activity by direct binding; STRA8 increases SETD8 promoter activity in a dose-dependent manner. Both proteins show cell cycle-dependent expression in germline cells, and SETD8/H4K20me1 co-localize with STRA8 in spermatogonia in vivo. Yeast two-hybrid, co-immunoprecipitation, domain-deletion mapping, promoter-reporter assays, immunofluorescence co-localization in mouse testis Journal of cellular and molecular medicine Medium 32090428
2020 STRA8 interacts with itself (homodimerizes) and with class I bHLH factor TCF3/E47 and gonadal-specific bHLH factor SOHLH1 through its HLH domain; this HLH domain mediates negative interference with E-box-mediated transcriptional activity of bHLH transcription factors. STRA8 indirectly exerts negative control on SOHLH1-dependent stimulation of c-KIT expression in late differentiating spermatogonia and preleptotene spermatocytes. Co-immunoprecipitation in male germ cells from prepuberal mouse testis, domain-deletion mutagenesis, luciferase reporter assays in transfected cell lines Journal of cellular and molecular medicine Medium 33236849
2021 STRA8 is required for proper transcriptional changes during spermatogonial development; RNA-seq at multiple RA-stimulated timepoints in wild-type vs. Stra8-KO mice showed that STRA8-null spermatogonia display a muted RA transcriptional response—retaining more undifferentiated-cell transcripts and fewer differentiating-cell transcripts—indicating that STRA8 mediates RA-driven transcriptional progression during spermatogonial differentiation. RNA-sequencing in wild-type and Stra8-KO mice at multiple timepoints of RA-stimulated spermatogonial development Molecular reproduction and development Medium 33400349
2021 STRA8 plays a crucial role in modulating the responsiveness of undifferentiated spermatogonia to retinoic acid; Stra8-KO germ cell cultures show failure to transition to differentiated state and downregulation of a large portfolio of genes including spermatogonial stem cell self-renewal pathway genes. Tcerg1l was identified as a downstream effector of RA-induced spermatogonial differentiation. Germ cell cultures from neonatal wild-type and Stra8-KO mice, RA treatment, RNA-seq, transplantation assays Biology of reproduction Medium 33959758
2021 Two functional retinoic acid response elements (RAREs) within the 2.9 kb Stra8 promoter are required for optimal Stra8 expression in fetal ovarian germ cells in vivo; CRISPR/Cas9-mediated mutation of either RARE reduces Stra8 expression. DMRT1 enhances Stra8 expression only in the presence of RA and the most proximal RARE. Transgenic reporter (2.9 kb Stra8 promoter-eGFP), in vitro promoter cutdown/mutation transfection assays, CRISPR/Cas9 targeted RARE mutation in vivo, DMRT1 co-transfection Development (Cambridge, England) High 33574039
2023 STRA8 binds RB via an LXCXE motif; mutation of this RB-binding site in female mice delays meiotic entry, delays meiotic prophase progression, and leads to precocious depletion of the oocyte pool. Single-cell RNA-seq showed that the STRA8-RB interaction is required for S-phase entry and meiotic gene activation, and STRA8 may sequester RB from E2F during pre-meiotic G1/S transition. LXCXE-motif knock-in mutation in mice, single-cell RNA-sequencing, oocyte pool quantification, meiotic progression analysis, protein interaction assays Nature communications High 37880249
2023 H3K27me3-associated chromatin remodelling at the Stra8 promoter is an ancestral mechanism that allows STRA8 expression in mammalian pre-meiotic germ cells; inhibition of H3K27me3 demethylation in tammar ovaries before meiotic prophase I reduces Stra8 but not Meiosin transcriptional levels, confirming differential epigenetic regulation of the two meiosis initiation factors. ChIP-seq analysis of H3K27me3 at STRA8/MEIOSIN promoters, DNase-seq, pharmacologic inhibition of H3K27me3 demethylation in ex vivo organ culture, cross-species comparison (mouse, opossum, tammar wallaby, platypus, echidna) Reproduction (Cambridge, England) Medium 36866926
2025 STRA8 is expressed in the adult mouse brain (not only in germ cells) and is induced by neuronal activity via calcium influx and NMDA receptor signaling. Neuron-specific Stra8 knockout causes DNA damage, impaired proteostasis, inflammation, nuclear envelope erosion, reduced dendritic plasticity, memory deficits, and disrupted inhibitory circuit function. Mechanistically, STRA8 binds regulatory regions of neuromodulator genes and represses their expression; Stra8 loss aberrantly upregulates Npas4 with mislocalization of the protein to the nuclear periphery. Neuron-specific Stra8 knockout, electrophysiology, ChIP (STRA8 binding at neuromodulator gene loci), immunofluorescence, behavioral tests, calcium imaging/NMDA receptor pharmacology Cell reports Medium 41187062
2025 STRA8-MEIOSIN transcription factor complex mediates the G1-to-meiotic S phase transition; MEIOC promotes meiotic entry by increasing Meiosin transcript abundance, thus activating the STRA8-MEIOSIN complex. STRA8-MEIOSIN upregulates Meioc, forming a positive feedback loop to reinforce timely meiotic initiation in oogenic cells. Meioc-null oogenic cell analysis, cell cycle transcriptomics, CCNA2 protein expression assays, Meiosin transcript quantification, BMP signaling manipulation bioRxivpreprint Medium
2025 NFYA expressed in pre-meiotic germ cells promotes accessible chromatin at meiotic gene promoters including those regulated by the STRA8/MEIOSIN axis; conditional Nfya deletion in male germ cells blocks meiotic entry and disrupts chromatin accessibility at STRA8/MEIOSIN target promoters as shown by spatial and single-cell ATAC-seq. Conditional Nfya knockout, spatial ATAC-seq, single-cell ATAC-seq, paused Pol II analysis bioRxivpreprint Low

Source papers

Stage 0 corpus · 55 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice. Proceedings of the National Academy of Sciences of the United States of America 494 18799751
1996 Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene. The Journal of cell biology 260 8896602
2008 Expression of stimulated by retinoic acid gene 8 (Stra8) in spermatogenic cells induced by retinoic acid: an in vivo study in vitamin A-sufficient postnatal murine testes. Biology of reproduction 222 18322276
2007 Expression of stimulated by retinoic acid gene 8 (Stra8) and maturation of murine gonocytes and spermatogonia induced by retinoic acid in vitro. Biology of reproduction 212 18032419
2015 Periodic retinoic acid-STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis. Proceedings of the National Academy of Sciences of the United States of America 185 25902548
2008 STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation. Journal of cell science 176 18799790
2011 DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary. Developmental biology 105 21621532
2009 STRA8 shuttles between nucleus and cytoplasm and displays transcriptional activity. The Journal of biological chemistry 70 19805549
2013 Incomplete cre-mediated excision leads to phenotypic differences between Stra8-iCre; Mov10l1(lox/lox) and Stra8-iCre; Mov10l1(lox/Δ) mice. Genesis (New York, N.Y. : 2000) 64 23554062
2011 Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biology of reproduction 56 21209416
2019 Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice. PLoS genetics 42 31059511
2014 CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways. Developmental biology 39 24576537
2016 Retinoic acid triggers meiosis initiation via stra8-dependent pathway in Southern catfish, Silurus meridionalis. General and comparative endocrinology 37 26764212
2018 Stimulated by retinoic acid gene 8 (Stra8) plays important roles in many stages of spermatogenesis. Asian journal of andrology 30 29848833
2016 Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming. PLoS biology 28 27606421
2021 STRA8 induces transcriptional changes in germ cells during spermatogonial development. Molecular reproduction and development 25 33400349
2017 CRISPR/Cas9 mediated chicken Stra8 gene knockout and inhibition of male germ cell differentiation. PloS one 25 28234938
2021 Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse. Development (Cambridge, England) 24 33574039
2020 Meiotic gatekeeper STRA8 regulates cell cycle by interacting with SETD8 during spermatogenesis. Journal of cellular and molecular medicine 23 32090428
2002 Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8. Journal of assisted reproduction and genetics 22 12489526
2013 Characterization of Stra8 in Southern catfish (Silurus meridionalis): evidence for its role in meiotic initiation. BMC molecular biology 19 23697400
2016 Overexpression of STRA8, BOULE, and DAZL Genes Promotes Goat Bone Marrow-Derived Mesenchymal Stem Cells In Vitro Transdifferentiation Toward Putative Male Germ Cells. Reproductive sciences (Thousand Oaks, Calif.) 18 27342271
2021 Roles of Stra8 and Tcerg1l in retinoic acid induced spermatogonial differentiation in mouse†. Biology of reproduction 17 33959758
2017 miR-31 Regulates Spermatogonial Stem Cells Meiosis via Targeting Stra8. Journal of cellular biochemistry 17 28543764
2015 SOHLH1 and SOHLH2 directly down-regulate STIMULATED BY RETINOIC ACID 8 (STRA8) expression. Cell cycle (Georgetown, Tex.) 17 25603532
2023 STRA8-RB interaction is required for timely entry of meiosis in mouse female germ cells. Nature communications 16 37880249
2019 Dietary Guanidinoacetic acid modulates testicular histology and expression of c-Kit and STRA8 genes in roosters. Theriogenology 16 30893638
2018 Stra8 may inhibit apoptosis during mouse spermatogenesis via the AKT signaling pathway. International journal of molecular medicine 15 30106128
2019 Induction of goat bone marrow mesenchymal stem cells into putative male germ cells using mRNA for STRA8, BOULE and DAZL. Cytotechnology 14 30767091
2013 Distinct roles for CBP and p300 on the RA-mediated expression of the meiosis commitment gene Stra8 in mouse embryonic stem cells. PloS one 14 23785470
2021 Loss of stra8 Increases Germ Cell Apoptosis but Is Still Compatible With Sperm Production in Atlantic Salmon (Salmo salar). Frontiers in cell and developmental biology 11 33942021
2025 BMP and STRA8 act collaboratively to ensure correct mitotic-to-meiotic transition in the fetal mouse ovary. Development (Cambridge, England) 9 39817676
2020 Stimulated by retinoic acid gene 8 (STRA8) interacts with the germ cell specific bHLH factor SOHLH1 and represses c-KIT expression in vitro. Journal of cellular and molecular medicine 9 33236849
2013 Expression of miR-34c in response to overexpression of Boule and Stra8 in dairy goat male germ line stem cells (mGSCs). Cell biochemistry and function 9 23508548
2013 Expression pattern of Ngn3 in dairy goat testis and its function in promoting meiosis by upregulating Stra8. Cell proliferation 9 24450812
2011 Transgenic Stra8-EYFP pigs: a model for developing male germ cell technologies. Transgenic research 9 21826492
2017 Expression of STRA8 is conserved in therian mammals but expression of CYP26B1 differs between marsupials and mice. Biology of reproduction 8 29044428
2022 Carob extract induces spermatogenesis in an infertile mouse model via upregulation of Prm1, Plzf, Bcl-6b, Dazl, Ngn3, Stra8, and Smc1b. Journal of ethnopharmacology 7 36209951
2021 SCF Improves In Vitro Differentiation of SSCs Through Transcriptionally Up-regulating PRTM1, STRA8, c-KIT, PIWIL2, and OCT4 Genes. Reproductive sciences (Thousand Oaks, Calif.) 7 33492648
2011 Retinoic acid induces myoblasts transdifferentiation into premeiotic Stra8-positive cells. Cell biology international 7 21091440
2023 Generation of a novel Stra8-driven Cre recombinase strain for use in pre-meiotic germ cells in mice†. Biology of reproduction 5 37279768
2021 Overexpression of DAZL, STRA8, and BOULE Genes and Treatment With BMP4 or Retinoic Acid Modulate the Expression of MSC Overexpressing Germ Cell Genes. Frontiers in veterinary science 5 34113673
2019 Effects of body temperature on the expression and localization of meiosis-related proteins STRA8 and SCP3 in boar testes. Acta histochemica 5 31253359
2015 The Induction Effect of Am80 and TSA on ESC Differentiation via Regulation of Stra8 in Chicken. PloS one 5 26606052
2014 Construction and quantitative evaluation of a dual specific promoter system for monitoring the expression status of Stra8 and c-kit genes. Molecular biotechnology 4 25260891
2010 [STRA8 as a specific expression marker in postnatal male germ cells]. Zhonghua nan ke xue = National journal of andrology 4 20369703
2023 Conserved H3K27me3-associated chromatin remodelling allows STRA8 but not MEIOSIN expression in mammalian germ cells. Reproduction (Cambridge, England) 3 36866926
2020 Regulatory functions of gga-miR-218 in spermatogonial stem cells meiosis by targeting Stra8. Mechanisms of development 3 32798699
2014 Cloning and expression characteristics of the pig Stra8 gene. International journal of molecular sciences 3 25029539
2009 [Stra8: a specifically expressed gene in premeiotic germ cells' transition from mitosis to meiosis]. Zhonghua nan ke xue = National journal of andrology 3 19288751
2013 The effects of Nanos2 on Boule and Stra8 in male germline stem cells (mGSCs). Molecular biology reports 2 23644984
2026 Generation of Stra8-Cre/ERT2 Mouse Activator Strain for Inducible Cre-lox Recombination in Spermatocytes. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 0 41912819
2025 Single-Cell Transcriptomic Analysis of the Potential Mechanisms of Follicular Development in Stra8-Deficient Mice. International journal of molecular sciences 0 40332359
2025 Stra8 links neuronal activity to inhibitory circuit protection in the adult mouse brain. Cell reports 0 41187062
2020 [Prokaryotic expression of mouse Stra8 and preparation and identification of rabbit anti-mouse Stra8 polyclonal antibody]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 0 32967766

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