Affinage

STEAP4

Metalloreductase STEAP4 · UniProt Q687X5

Length
459 aa
Mass
52.0 kDa
Annotated
2026-06-10
99 papers in source corpus 44 papers cited in narrative 44 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/8 claims corpus-supported (88%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

STEAP4 (STAMP2/TIARP) is a six-transmembrane metalloreductase that integrates metal homeostasis with inflammatory and metabolic signaling across adipose, immune, hepatic, skeletal, and cancer cells (PMID:17482547, PMID:22704678). Its oxidoreductase domain harbors a novel interdomain flavin-binding site that shuttles electrons from NADPH to reduce extracytoplasmic Fe³⁺ and Cu²⁺, with kinetics retained at acidic pH consistent with activity at intracellular organelles (PMID:23733181). Through this ferric/cupric reductase activity STEAP4 controls cellular ferrous iron, cuprous copper, NADPH, and ROS levels, and these metal/redox outputs are the proximal cause of its diverse biology: reduced iron and ROS drive CREB-dependent osteoclast differentiation (PMID:23990467), while loss of STEAP4 elevates NADPH and exaggerates macrophage inflammation, a defect rescued by wild-type but not reductase-dead protein (PMID:22704678). Germline deletion produces spontaneous insulin resistance, dyslipidemia, fatty liver, and visceral adipose inflammation, establishing STEAP4 as essential for systemic metabolic homeostasis (PMID:17482547). In metabolic tissues it enhances insulin-stimulated GLUT4 translocation and glucose uptake via Akt/PI3K signaling and stabilizes IRS-1 (PMID:21468601, PMID:25646886), and SIRT3-mediated deacetylation at K404 directs STEAP4 to mitochondria where it supports respiratory chain function and TCA-versus-glycolytic balance (PMID:41840161, PMID:39995871). STEAP4 acts as a key effector downstream of inflammatory cytokines: IL-17 induces STEAP4-dependent copper uptake that activates XIAP and NF-κB to drive colitis-associated tumorigenesis (PMID:32060280), and STEAP4 is a Th17-specific effector in CNS-resident cells during autoimmune encephalomyelitis (PMID:33879167). In cancer its iron-reductase-driven ROS modulates ATF4, NRF2-NQO1, and AKT/mTOR pathways, with both tumor-promoting and tumor-suppressive outcomes depending on context (PMID:25680860, PMID:40205952, PMID:38111065). STEAP4 transcription is controlled by an extensive regulatory network including STAT3 and C/EBPα/β, FOXO1, GATA3, SOX2, and NF-κB/REL (PMID:20304921, PMID:23262293, PMID:37506793, PMID:41422349, PMID:40877891, PMID:41115643), while its protein abundance is set by K48-linked ubiquitin-proteasomal degradation that is opposed by HERP-mediated stabilization (PMID:41317904, PMID:41249464).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2001 Medium

    Established STEAP4 as a cytokine-responsive transmembrane protein, first linking it to TNF-alpha signaling and adipocyte differentiation before any enzymatic function was known.

    Evidence Differential display, Northern blot, and immunofluorescence in TNF-alpha-treated 3T3-L1 adipocytes

    PMID:11443137

    Open questions at the time
    • No molecular activity assigned
    • Mechanism of cytokine responsiveness not defined
  2. 2005 Medium

    Mapped STEAP4 subcellular distribution to Golgi, plasma membrane, endosomal and caveolar compartments and tied its expression to androgen signaling, raising a candidate role in prostate cancer growth.

    Evidence GFP live-cell imaging, confocal co-localization with EEA1 and caveolin-1, androgen treatment and colony assays in prostate cells/adipocytes

    PMID:15836432 PMID:15897894

    Open questions at the time
    • Co-localization is correlative
    • EEA1 association later refuted by FRET
    • No enzymatic mechanism for growth effect
  3. 2007 High

    Demonstrated that STEAP4 is essential for systemic metabolic homeostasis, defining it as an integrator of inflammation and metabolism in vivo.

    Evidence Germline knockout mouse metabolic and inflammatory phenotyping

    PMID:17482547

    Open questions at the time
    • Did not identify the biochemical activity underlying the phenotype
    • Tissue-of-origin of metabolic defect unresolved
  4. 2010 High

    Connected STEAP4 function to insulin action, showing it enhances insulin-stimulated glucose uptake, and identified STAT3 and C/EBP-alpha as direct transcriptional inputs.

    Evidence Glucose uptake assays with overexpression in human adipocytes; ChIP and reporter assays in mouse liver with IL-6/STAT3

    PMID:20127040 PMID:20304921

    Open questions at the time
    • Glucose uptake mechanism not yet linked to a defined signaling node
    • Cytokine-to-promoter wiring described in liver only
  5. 2012 High

    Established the reductase activity as the cause of STEAP4's anti-inflammatory function by showing NADPH homeostasis controls macrophage inflammation and atherosclerosis protection.

    Evidence Knockout macrophages, NADPH measurement, reductase-deficient mutant rescue, bone marrow transplantation atherosclerosis model

    PMID:22244520 PMID:22704678

    Open questions at the time
    • Direct enzymatic substrate in cells not measured
    • Link between NADPH pool and inflammatory output incompletely defined
  6. 2013 High

    Solved the oxidoreductase domain structure and defined STEAP4 as a flavin-dependent NADPH metalloreductase with physiological Fe(3+)/Cu(2+) kinetics, providing the biochemical basis for all downstream metal/redox biology.

    Evidence X-ray crystallography, in vitro kinetics, site-directed mutagenesis; parallel ferrireductase loss-of-function in osteoclasts

    PMID:23733181 PMID:23990467

    Open questions at the time
    • Full-length transmembrane structure not solved
    • In vivo electron donor/acceptor topology not directly visualized
  7. 2015 Medium

    Resolved the hepatic and cancer arms of STEAP4 biology, showing it stabilizes IRS-1 to protect insulin signaling and that its iron-reductase-driven ROS/NADPH depletion engages ATF4 to control tumor growth.

    Evidence Co-IP, protein stability assays, bidirectional in vivo manipulation; ROS/NADPH measurement, knockdown, and nanoliposomal siRNA xenograft models

    PMID:23095254 PMID:25646886 PMID:25680860

    Open questions at the time
    • IRS-1 stabilization mechanism (direct vs indirect) unresolved
    • ATF4 induction shown to be partial mediator only
  8. 2017 High

    Localized a pathogenic STEAP4 activity to mitochondria, showing hypoxia-induced STEAP4 dysregulates mitochondrial iron to drive ROS, colitis, and tumorigenesis.

    Evidence Unbiased proteomics, mouse colitis and colitis-associated cancer models, mitochondrial iron chelation rescue

    PMID:29078383

    Open questions at the time
    • Mechanism of mitochondrial targeting not yet defined here
    • How mitochondrial iron is delivered to STEAP4 unclear
  9. 2020 High

    Defined STEAP4 as an inducible copper reductase in inflammatory signaling, placing it downstream of IL-17 to drive XIAP/NF-kB activation and tumorigenesis, and connected it to hepatic iron export.

    Evidence Gene knockout, copper measurement, XIAP/NF-kB/caspase assays, colitis-associated tumor model; FGF21/ferroportin hepatic studies

    PMID:32060280 PMID:32721044

    Open questions at the time
    • Direct copper transfer to XIAP not demonstrated
    • Ferroportin regulation mechanism downstream of STEAP4 indirect
  10. 2021 High

    Established STEAP4 as a cell-type-specific, Th17-pathway effector in vivo using conditional deletion, distinguishing its inflammatory roles by lineage.

    Evidence Global and Nestin-Cre conditional knockout mice in active and passive Th17/Th1 EAE

    PMID:33879167

    Open questions at the time
    • Molecular effector mechanism in CNS-resident cells not defined
    • Link to metalloreductase activity not directly tested
  11. 2023 Medium

    Expanded the transcriptional control of STEAP4 and dissected context-dependent AKT/mTOR coupling, showing STEAP4 can either inhibit or sustain AKT signaling depending on cell type.

    Evidence FOXO1 ChIP and promoter mutagenesis; co-IP and pharmacological rescue (SC79/MK2206) in HCC and prostate epithelial cells

    PMID:37506793 PMID:37866665 PMID:38111065

    Open questions at the time
    • Opposing AKT effects across tissues unreconciled
    • Physical STEAP4-AKT interaction shown by single Co-IP
  12. 2025 High

    Defined STEAP4 protein-level control and additional roles in mitochondrial integrity, lysosomal iron handling, and redox-driven transcription, while broadening its regulatory network.

    Evidence HERP/ubiquitin and K48-ubiquitylome mass spectrometry; adipocyte- and liver-conditional KO with interactome/RNA-seq/lysosomal fractionation; ROS/NRF2-NQO1 and NRF2/NOTCH1 pathway dissection; GATA3, SOX2, REL, NAMPT-SIRT1-C/EBP-beta transcriptional studies

    PMID:39995871 PMID:40205952 PMID:40877891 PMID:41115643 PMID:41201016 PMID:41249464 PMID:41276039 PMID:41317904 PMID:41324246 PMID:41422349 PMID:41838890

    Open questions at the time
    • Some ROS effects reported as independent of canonical ferric reductase activity, not mechanistically reconciled
    • Mitochondrial vs lysosomal iron pools handled by STEAP4 not unified
    • RNA splicing interactome role uncharacterized mechanistically
  13. 2026 High

    Identified post-translational control of STEAP4 mitochondrial targeting via SIRT3 deacetylation at K404, linking acetylation status to metabolic fate and cuproptosis sensitivity.

    Evidence Site-specific K404 mutagenesis, deacetylation assay, mitochondrial fractionation, metabolic flux, HBx mouse and orthotopic HCC models

    PMID:41840161

    Open questions at the time
    • Acetyltransferase opposing SIRT3 not identified
    • Generality of K404 regulation beyond HCC unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How STEAP4 partitions its single reductase activity among plasma membrane, endosomal/lysosomal, and mitochondrial pools to produce tissue- and context-specific (protective vs pathogenic) outcomes remains unresolved.
  • No unified model linking subcellular localization to metal/redox output and downstream pathway selection
  • Reductase-independent antioxidant effects reported but mechanistically unexplained
  • Direct in vivo substrate flux at each organelle not measured

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016491 oxidoreductase activity 6 GO:0140657 ATP-dependent activity 1
Localization
GO:0005739 mitochondrion 3 GO:0005886 plasma membrane 3 GO:0005764 lysosome 2 GO:0005768 endosome 2 GO:0005794 Golgi apparatus 1
Pathway
R-HSA-74160 Gene expression (Transcription) 6 R-HSA-1430728 Metabolism 4 R-HSA-1643685 Disease 4 R-HSA-168256 Immune System 3 R-HSA-8953897 Cellular responses to stimuli 3
Partners
AKTFAKHBXHERPSIRT3XIAP

Evidence

Reading pass · 44 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 Crystal structure of the Steap4 oxidoreductase domain was determined, revealing a novel interdomain flavin-binding site that shuttles electrons between the oxidoreductase and transmembrane domains. Detailed kinetic analysis showed physiologically relevant Km values for Fe(3+) and Cu(2+), flavin-dependent NADPH oxidase activity greater than Steap3, and retained activity at acidic pH suggesting intracellular organelle function. Structure-function mutagenesis showed disordered N-terminal residues do not contribute to enzymatic activity. X-ray crystallography, in vitro kinetic assay, site-directed mutagenesis The Journal of biological chemistry High 23733181
2007 STAMP2 (STEAP4) acts as a critical integrator of inflammatory and metabolic responses in adipocytes. STAMP2-knockout mice on a regular diet develop spontaneous insulin resistance, glucose intolerance, mild hyperglycemia, dyslipidemia, and fatty liver disease with overt visceral adipose tissue inflammation, establishing STAMP2 as essential for metabolic homeostasis. Germline knockout mouse model, metabolic phenotyping, inflammatory marker analysis Cell High 17482547
2012 Stamp2 controls macrophage inflammation through NADPH homeostasis: absence of Stamp2 results in significantly elevated cellular NADPH levels, and the exaggerated inflammatory response in Stamp2-/- macrophages is rescued by wild-type but not reductase-deficient Stamp2. Chemical and genetic suppression of NADPH production in Stamp2-/- macrophages reverts the heightened inflammatory response. Bone marrow transplantation confirmed Stamp2 in myeloid cells is sufficient to protect against atherosclerosis. Knockout macrophages, NADPH measurement, reductase-deficient mutant rescue, bone marrow transplantation, atherosclerosis model Cell metabolism High 22704678
2013 Steap4 functions as an endosomal ferrireductase in osteoclasts. Knockdown of Steap4 by lentivirus-mediated shRNA inhibits osteoclast formation in vitro and decreases cellular ferrous iron, reactive oxygen species, and activation of CREB, a transcription factor required for osteoclast differentiation downstream of RANKL-induced calcium signaling. Lentivirus-mediated shRNA knockdown, ferrous iron measurement, ROS assay, CREB phosphorylation assay, osteoclast differentiation assay The Journal of biological chemistry High 23990467
2020 IL-17 induces cellular copper uptake via induction of STEAP4 (a metalloreductase). Elevated intracellular copper activates the E3 ligase XIAP, which potentiates IL-17-induced NF-κB activation and suppresses caspase-3 activity. STEAP4 deficiency abrogated IL-17-induced copper uptake and colon tumor formation in a colitis-associated tumorigenesis model. Gene knockout mouse model, copper measurement, XIAP activity assay, NF-κB reporter, caspase-3 activity assay, colitis-associated tumorigenesis model Nature communications High 32060280
2017 STEAP4 is a ferrireductase induced by hypoxia in colitis; its expression leads to dysregulation of mitochondrial iron balance and enhanced reactive oxygen species production, increasing susceptibility to colitis and promoting colon tumor formation. Mitochondrial iron chelation therapy improved colitis, establishing mitochondrial iron dysregulation as a key mechanism. Unbiased proteomics, mouse colitis model, colitis-associated cancer model, mitochondrial iron chelation Proceedings of the National Academy of Sciences of the United States of America High 29078383
2005 STAMP2 (STEAP4) localizes primarily to the Golgi complex, trans-Golgi network, plasma membrane, and vesicular-tubular cytosolic structures. It co-localizes with Early Endosome Antigen 1 (EEA1), suggesting involvement in secretory/endocytic pathways. Expression is androgen-regulated in androgen receptor-positive LNCaP cells but not in AR-negative PC-3 or DU145 cells. Ectopic expression increases prostate cancer cell growth and colony formation. GFP-fusion live-cell imaging, immunofluorescence confocal microscopy, co-localization with EEA1, androgen treatment assays, colony formation assay Oncogene Medium 15897894
2001 TIARP (STEAP4) is a TNF-alpha-inducible transmembrane protein that emerges at the plasma membrane during adipocyte differentiation. Commitment to the differentiation process is required for cytokine responsiveness, and differentiation itself induces sharp TIARP mRNA expression. Differential display, immunofluorescence, Northern blot, TNF-alpha treatment of 3T3-L1 cells The Journal of biological chemistry Medium 11443137
2005 TIARP (STEAP4) co-localizes with caveolin-1 as patches at the plasma membrane of 3T3-L1 adipocytes, detected by confocal microscopy. Immunoblot analysis showed TIARP is completely detergent-extractible from membranes, whereas caveolin-1 is present in both extractible and -insoluble pools, indicating TIARP partitions within caveolae signaling domains. Confocal microscopy co-localization, detergent extraction fractionation, immunoblot Biology of the cell Medium 15836432
2009 STEAP4 associates with focal adhesion kinase (FAK) and regulates FAK activity through Y397 phosphorylation. STEAP4 expression inhibits anchorage-independent cell growth. CpG sequences in the STEAP4 promoter are frequently methylated in androgen-independent DU145 prostate cancer cells, and demethylation treatment induces STEAP4 expression. Co-immunoprecipitation, FAK phosphorylation assay, soft agar colony assay, methylation-specific PCR, demethylation treatment International journal of molecular medicine Medium 19787193
2010 STEAP4 promotes insulin-stimulated glucose uptake in mature human adipocytes. Overexpression of STEAP4 does not affect adipogenesis but enhances 2-deoxy-D-glucose uptake in a PI3K-dependent manner. Expression is regulated by adipokines TNF-alpha, IL-6, and leptin. 2-deoxy-D-[3H]-glucose uptake assay, oil red O staining, Western blotting, RT-PCR International journal of molecular medicine Medium 20127040
2010 Hepatic STEAP4 transcription is a direct target of phosphorylated STAT3 in mouse liver, induced by IL-6. In addition, CCAAT/enhancer-binding protein alpha (C/EBPα) is required for STEAP4 regulation during feeding/fasting and obesity, acting in concert with STAT3; both factors bind the proximal steap4 promoter in vivo. Chromatin immunoprecipitation (ChIP), luciferase reporter assay, IL-6 treatment, STAT3 phosphorylation analysis The Journal of biological chemistry High 20304921
2011 siRNA-mediated STEAP4 knockdown significantly decreases insulin-stimulated glucose transport in human adipocytes by reducing GLUT4 translocation to the plasma membrane via attenuated Akt phosphorylation. STEAP4 does not interact with EEA1 (confirmed by FRET analysis) and does not alter EEA1 protein expression, establishing that the effect on glucose uptake is EEA1-independent. siRNA knockdown, 2-deoxy-glucose uptake assay, GLUT4 translocation assay, Akt phosphorylation western blot, FRET analysis Molecular medicine reports Medium 21468601
2015 STAMP2 increases reactive oxygen species through its iron reductase activity, which also depletes NADPH levels in prostate cancer cells. Knockdown inhibits proliferation, colony formation, anchorage-independent growth, and increases apoptosis. STAMP2 effects are mediated at least in part through ATF4, whose expression is regulated by ROS. Systemic nanoliposomal siRNA silencing of STAMP2 profoundly inhibited PCa tumor growth in two preclinical models. ROS measurement, NADPH assay, shRNA/siRNA knockdown, in vitro proliferation/apoptosis assays, xenograft models, nanoliposomal siRNA delivery EMBO molecular medicine High 25680860
2015 Hepatic STAMP2 physically interacts with and decreases the stability of hepatitis B virus X protein (HBx), counteracting HBx-induced hepatic lipid accumulation and insulin resistance. STAMP2 prevented HBx-induced degradation of IRS1 protein and restored insulin-mediated inhibition of gluconeogenic enzyme expression. Co-immunoprecipitation, protein stability assay, HBx transgenic mouse analysis, Western blot for IRS1 and gluconeogenic enzymes Experimental & molecular medicine Medium 23095254
2015 Hepatic STAMP2 modulates insulin sensitivity via IRS-1 stability. Knockdown of hepatic STAMP2 by siRNA accelerated hepatic steatosis and insulin resistance in HFD mice; adenoviral STAMP2 delivery improved hepatic steatosis and counteracted oleic acid-induced insulin resistance by modulating IRS-1 stability. In vivo siRNA knockdown, adenoviral overexpression, glucose/insulin tolerance tests, IRS-1 protein stability assay, in vitro NAFLD model Journal of hepatology Medium 25646886
2011 STEAP4 is induced by TNF-alpha in fibroblast-like synoviocytes (FLS) and localizes to endosomal/lysosomal compartments. STEAP4 downregulation by siRNA enhanced IL-6 mRNA expression; overexpression suppressed IL-6 and IL-8 expression, inhibited cell proliferation, and induced apoptosis via caspase-3 in FLS. siRNA knockdown, plasmid overexpression, IL-6/IL-8 ELISA, proliferation assay, caspase-3 apoptosis assay, immunofluorescence localization Modern rheumatology Medium 21633911
2012 STEAP4 overexpression in neutrophil-like HL60 cells down-regulates neutrophil migration in a transwell assay. TIARP/STEAP4-deficient neutrophils overexpress CXCR1 and CXCR2 and show enhanced migration activity facilitated by CXCL2 in vitro and in vivo. GFP-STEAP4 overexpression, transwell migration assay, DNA microarray of TIARP-/- neutrophils, in vivo K/BxN serum transfer arthritis model Clinical and experimental rheumatology Medium 22244520
2016 TIARP (STEAP4) attenuates arthritis by independently down-regulating CXCL2 and IL-6 production by fibroblast-like synoviocytes and reducing CXCR1/CXCR2 expression in neutrophils, reducing neutrophil migration into arthritic joints. IL-6R blockade significantly attenuated arthritis in TIARP-/- mice with diminished neutrophil recruitment. TIARP-/- mouse K/BxN serum transfer model, DNA microarray, in vitro neutrophil migration assay, anti-IL-6R antibody blockade, immunohistochemistry Scientific reports Medium 27995997
2019 ER stress (induced by thapsigargin or tunicamycin) significantly reduces STAMP2 mRNA and protein expression and alters its intracellular localization in adipocytes, reducing total iron reductase activity. TNF-alpha has the opposite effect. Promoter analysis by reporter assays and ChIP showed that ER stress disrupts C/EBPα-mediated STAMP2 transcription. ER stress inducers, iron reductase activity assay, luciferase promoter reporter, ChIP assay, immunofluorescence localization Metabolism: clinical and experimental Medium 30710574
2012 C/EBPβ directly regulates STEAP4 gene transcription by binding the C/EBPβ binding motif at -73/-59 bp of the STEAP4 promoter, as demonstrated by progressive deletions, site-directed mutations of the promoter construct, and ChIP assays. C/EBPβ protein levels increase with LPS treatment in parallel with STEAP4 and its splice variant induction. Promoter deletion constructs, site-directed mutagenesis, luciferase reporter assay, chromatin immunoprecipitation (ChIP) The international journal of biochemistry & cell biology Medium 23262293
2018 Articular chondrocytes gain resistance to lipotoxicity through a PKCK2-STAMP2-FSP27 signaling cascade that promotes lipid droplet accumulation, sequestering free fatty acids. Lipid droplet accumulation confers resistance to oleate-induced lipotoxicity; when FFAs are freed from lipid droplets, lipotoxicity occurs regardless of saturation status. HFD-induced OA mouse model, in vitro chondrocyte treatment, lipid droplet quantification, PKCK2 inhibition, STAMP2 and FSP27 knockdown/overexpression Bone research Medium 30002945
2018 AMPK functions upstream of STAMP2 to regulate its expression. Cilostazol activates AMPK in vivo and in vitro, which drives transcriptional upregulation of STAMP2, reversing HFD- and oleic acid-induced STAMP2 downregulation and ameliorating hepatic steatosis. HFD mouse model, HepG2 cells, AMPK inhibitors/activators, Western blot, qPCR, in vivo and in vitro STAMP2 expression analysis Molecular pharmacology Medium 30366981
2021 STEAP4 is a downstream effector molecule specifically in the IL-17/Th17 signaling pathway in the CNS. STEAP4 knockout mice are resistant to Th17- but not Th1-induced experimental autoimmune encephalomyelitis (EAE); ablation of STEAP4 specifically in CNS-resident cells (Nestin-Cre STEAP4fl/fl) attenuated disease in both active and passive Th17 EAE. Global and conditional (Nestin-Cre) STEAP4 knockout mice, active immunization EAE, passive Th17/Th1 transfer EAE, microarray analysis Journal of neuroinflammation High 33879167
2022 In Stamp2-deficient mice after myocardial ischemia-reperfusion, augmented neutrophil infiltration produces excess ROS activating the redox-sensitive p38 MAPK, driving fibroblast-to-myofibroblast transdifferentiation and cardiac fibrosis. Antibody-mediated neutrophil depletion in Stamp2-/- mice reduced deterioration of cardiac function to WT levels, establishing PMN as the key cellular mediator. Stamp2-/- mouse I/R model, echocardiography, histology, ROS measurement, p38 MAPK assay, MPO measurement, neutrophil depletion antibody Frontiers in immunology Medium 34691017
2023 FOXO1 directly binds to the promoter regions of CD36 and STEAP4 genes and regulates their transcriptional activities, as confirmed by chromatin immunoprecipitation (ChIP) and site-directed mutagenesis of promoter binding sites in bovine adipocytes. Chromatin immunoprecipitation (ChIP), site-directed mutagenesis, luciferase reporter assay, siRNA knockdown International journal of biological macromolecules Medium 37506793
2023 STEAP4 physically interacts with AKT and inhibits the PI3K/AKT pathway, suppressing cisplatin resistance in hepatocellular carcinoma. Double knockdown of STEAP4 and AKT significantly inhibited cisplatin resistance, and STEAP4 expression negatively correlates with PI3K/AKT pathway activity in clinical specimens. Co-immunoprecipitation, siRNA double knockdown, cell viability/colony/apoptosis assays, xenograft tumor model, clinical specimen correlation Cancer & metabolism Medium 38111065
2023 STEAP4 regulates proliferation and apoptosis of prostate epithelial cells (BPH context) through the AKT/mTOR signaling pathway. STEAP4 knockdown induces apoptosis and inhibits cell survival; AKT/mTOR activator SC79 reverses STEAP4 knockdown-induced apoptosis, and AKT/mTOR inhibitor MK2206 reduces STEAP4 OE-induced viability increase. siRNA knockdown, overexpression, CCK-8 assay, flow cytometry, SC79/MK2206 pharmacological rescue, Western blot for AKT/mTOR pathway Cellular signalling Medium 37866665
2020 Recombinant FGF21 ameliorates hepatic steatosis and insulin resistance through upregulation of STAMP2 expression, and improves hepatic iron overload (HIO) through hepatic STAMP2-mediated upregulation of ferroportin expression, an iron exporter. HFD mouse model, human NAFLD samples, HepG2 cells, adenoviral STAMP2 overexpression, ferroportin Western blot, iron measurement FASEB journal Medium 32721044
2016 STAMP2 is required for human adipose-derived stem cell (ASC) differentiation into adipocytes. shRNA-mediated STAMP2 knockdown in ASCs significantly suppresses adipogenesis and impairs optimal expression of adipogenic genes and adipocyte metabolic function. ASC-derived adipocyte-mediated stimulation of prostate tumor growth in nude mice is significantly reduced upon STAMP2 knockdown. shRNA knockdown in human ASCs, adipogenesis assay, adipogenic gene expression, nude mouse co-implantation tumor model Oncotarget Medium 29190878
2022 STAMP2 suppresses autophagy in prostate cancer cells through modulation of the integrated stress response axis (ATF4 pathway). STAMP2 also regulates mitochondrial respiration. STAMP2 knockdown/overexpression, autophagy flux assay, mitochondrial respiration measurement (Seahorse) American journal of cancer research Low 35141021
2025 HERP interacts with STEAP4 to prevent its ubiquitin-mediated proteasomal degradation, stabilizing STEAP4 protein. HERP regulates adipogenesis through STEAP4 in a PPARγ-dependent manner. Enhancing STEAP4 expression ameliorated adipose expansion and metabolic disorders in HERP-KO mice. Co-immunoprecipitation, HERP KO mouse, STEAP4 ubiquitination assay, PPARγ pathway analysis, adenoviral STEAP4 rescue Cell death and differentiation Medium 41249464
2025 STEAP4 promotes intracellular Fe2+ accumulation and ROS elevation, upregulating C/EBPβ expression. C/EBPβ in turn binds a functional site in the Steap4 promoter and upregulates Steap4, establishing a self-amplifying Steap4/Fe2+-ROS/C/EBPβ positive feedback loop. Knockdown of Steap4 or C/EBPβ suppressed BMSC adipocyte differentiation. Knockdown studies, C/EBPβ promoter binding assay, Fe2+ measurement, ROS assay, adipogenic differentiation assay, deferoxamine treatment in vivo Advanced science Medium 41201016
2026 SIRT3 deacetylates STEAP4 at lysine 404, which is required for its mitochondrial targeting. HBx attenuates SIRT3, impairing STEAP4 deacetylation and abolishing its mitochondrial localization. Loss of mitochondrial STEAP4 drives a switch from TCA cycle respiration to glycolysis, reducing cuproptosis sensitivity. Restoring STEAP4 or activating SIRT3 with honokiol re-instates mitochondrial STEAP4 and re-sensitizes HBV-related HCC cells to cuproptosis. Deacetylation assay, site-specific mutagenesis (K404), mitochondrial fractionation, metabolic flux analysis, HBx-transgenic mice, pharmacological SIRT3 activation, orthotopic HCC model Cell death and differentiation High 41840161
2025 STEAP4 reduces intracellular ROS by selectively enhancing activities of antioxidant enzymes SOD and GPX, independently of its canonical ferric reductase function. The consequent ROS reduction inhibits NRF2 nuclear translocation, suppressing NOTCH1 transcription through direct NRF2 promoter binding; restoring ROS levels reversed this inhibitory effect in TNBC cells. ROS measurement, SOD/GPX activity assays, NRF2 nuclear translocation assay, NOTCH1 promoter assay, NRF2 ChIP-like analysis, overexpression/knockdown International journal of biological macromolecules Medium 41276039
2025 STEAP4 knockout significantly reduces colon tumorigenesis in a genetically engineered mouse model. STEAP4 knockdown attenuates the NRF2-NQO1 signaling pathway in colon cancer cells, inducing apoptosis and autophagy. STEAP4 overexpression amplifies ROS production and activates NRF2-NQO1 in a ferric iron (Fe3+)-dependent manner. NQO1-bioactivatable drugs are highly effective at eradicating STEAP4-overexpressing colon cancer cells. Genetically engineered KO mouse model, shRNA knockdown, STEAP4 overexpression, ROS assay, NRF2/NQO1 pathway analysis, xenograft growth assay, NQO1-targeted drug treatment Journal of cell science High 40205952
2025 Adipocyte-specific Steap4 deficiency impairs respiratory chain complex activity and causes mitochondrial dysfunction in white adipose tissue. Mass spectrometry identified STEAP4 interactomes as mitochondrial proteins and RNA splicing proteins; Steap4 deficiency altered RNA splicing patterns with enriched mitochondrial functions by RNA-seq. Brown adipocyte-specific Steap4 deficiency impaired mitochondrial function, increased brown fat whitening, reduced energy expenditure, and exacerbated insulin resistance. Adipocyte-conditional KO, mass spectrometry interactome, RNA-seq splicing analysis, respiratory chain complex activity assay, metabolic cage energy expenditure measurement iScience High 39995871
2026 STEAP4 maintains lysosomal iron homeostasis and prevents lysosomal membrane damage. In liver-specific STEAP4 KO mice, APAP treatment caused iron buildup in endolysosomes, lysosomal membrane damage, release of cathepsin B, impaired mTOR activity, defective mitophagy, and reduced hepatocyte proliferation at 48h. STEAP4 is not essential during early injury but is critical for liver regeneration. Liver-specific KO (Alb-Cre Steap4fl/fl), APAP model, lysosomal fractionation, cathepsin B assay, mTOR signaling analysis, iron measurement, DFP chelation rescue Hepatology High 41838890
2025 Lithium exposure upregulates FOXO1, which promotes FOXO1-mediated STEAP4 transcription. Upregulated STEAP4 elevates intracellular Cu+ levels causing cuproptosis in trophoblasts, inducing miscarriage. Therapeutic knockdown of FOXO1 or STEAP4, or Cu chelation with TTM, suppressed placental cuproptosis and alleviated miscarriage in Li-exposed mice. Mouse Li-exposure model, ChIP for FOXO1-STEAP4 promoter, Cu+ measurement, cuproptosis markers, AAV-mediated KD, TTM treatment Advanced science Medium 40855689
2025 REL (a NF-κB subunit) enhances STEAP4 expression by binding to its promoter, as demonstrated by transcriptome analysis and in vitro cellular experiments in valvular interstitial cells. STEAP4-mediated iron overload drives ferroptosis contributing to aortic valve calcification. Transcriptome analysis, luciferase reporter or promoter binding assay, STEAP4 knockdown/overexpression in hVICs, ferroptosis inhibitor treatment, ApoE-/- HFD and wire-injury mouse models Free radical biology & medicine Medium 41115643
2025 HDAC2 directly interacts with SOX2 to inhibit its acetylation and destabilize the SOX2 protein. SOX2 binds to the STAMP2 promoter region and modulates its transcriptional activity. The HDAC2/SOX2/STAMP2 axis regulates macrophage activation in septic lung injury. Co-immunoprecipitation, luciferase assay, chromatin immunoprecipitation (ChIP), CLP mouse model, LPS-macrophage model European journal of medical research Medium 40877891
2026 NAMPT regulates STEAP4 expression through the SIRT1-C/EBPβ axis: NAMPT drives NAD+ synthesis enabling SIRT1 deacetylase activity, which deacetylates C/EBPβ to allow its function as a STEAP4 transcriptional activator. STEAP4 in turn upregulates NRF2 expression and nuclear translocation to combat oxidative stress in NAFLD. NAMPT/SIRT1 inhibition in HFD mice, C/EBPβ acetylation assay, STEAP4 promoter analysis, NRF2 nuclear translocation assay Journal of molecular cell biology Medium 41324246
2025 GATA3 transcriptionally activates STEAP4 by binding to its promoter, as confirmed by ChIP-PCR and dual-luciferase assays. STEAP4 knockdown inhibited Th2 differentiation and Th2-related cytokine production in vitro; STEAP4 knockdown rescued the promoting effects of GATA3 overexpression on Th2 differentiation, placing STEAP4 downstream of GATA3 in this pathway. ChIP-PCR, dual-luciferase reporter assay, siRNA knockdown, GATA3 overexpression, Th2 differentiation assay, OVA mouse model Inflammation Medium 41422349
2025 STEAP4 is ubiquitinated via K48-linked ubiquitin chains in obese visceral adipose tissue, leading to proteasomal degradation and reduced STEAP4 protein levels. Knockdown of STEAP4 in 3T3-L1 adipocytes impaired mitochondrial function. Combined proteomics and ubiquitylome mass spectrometry of visceral adipose tissue, siRNA knockdown, mitochondrial function assay Molecular & cellular proteomics Medium 41317904

Source papers

Stage 0 corpus · 99 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell 178 17482547
2020 Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis. Nature communications 172 32060280
2005 Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer. Oncogene 114 15897894
2017 Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Proceedings of the National Academy of Sciences of the United States of America 98 29078383
2017 STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper. The Journal of endocrinology 97 28576871
2001 Tumor necrosis factor-alpha-induced adipose-related protein (TIARP), a cell-surface protein that is highly induced by tumor necrosis factor-alpha and adipose conversion. The Journal of biological chemistry 92 11443137
2013 Induction of STEAP4 correlates with 1,25-dihydroxyvitamin D3 stimulation of adipogenesis in mesenchymal progenitor cells derived from human adipose tissue. Journal of cellular physiology 90 23553608
2013 Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation. The Journal of biological chemistry 75 23990467
2015 STAMP2 increases oxidative stress and is critical for prostate cancer. EMBO molecular medicine 57 25680860
2008 Downregulation of STEAP4, a highly-expressed TNF-alpha-inducible gene in adipose tissue, is associated with obesity in humans. Acta pharmacologica Sinica 49 18430367
2017 Long noncoding RNA SchLAH suppresses metastasis of hepatocellular carcinoma through interacting with fused in sarcoma. Cancer science 45 28196303
2012 Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis. Cell metabolism 44 22704678
2015 Hepatic STAMP2 alleviates high fat diet-induced hepatic steatosis and insulin resistance. Journal of hepatology 43 25646886
2010 STEAP4, a gene associated with insulin sensitivity, is regulated by several adipokines in human adipocytes. International journal of molecular medicine 42 20127040
2010 Regulation of hepatic six transmembrane epithelial antigen of prostate 4 (STEAP4) expression by STAT3 and CCAAT/enhancer-binding protein alpha. The Journal of biological chemistry 36 20304921
2011 Decreased STAMP2 expression in association with visceral adipose tissue dysfunction. The Journal of clinical endocrinology and metabolism 35 21849520
2013 The crystal structure of six-transmembrane epithelial antigen of the prostate 4 (Steap4), a ferri/cuprireductase, suggests a novel interdomain flavin-binding site. The Journal of biological chemistry 34 23733181
2023 FOXO1 regulates the formation of bovine fat by targeting CD36 and STEAP4. International journal of biological macromolecules 32 37506793
2021 STEAP4 knockdown inhibits the proliferation of prostate cancer cells by activating the cGMP-PKG pathway under lipopolysaccharide-induced inflammatory microenvironment. International immunopharmacology 32 34768126
2011 Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis. Modern rheumatology 31 21633911
2013 Overexpressing STAMP2 improves insulin resistance in diabetic ApoE⁻/⁻/LDLR⁻/⁻ mice via macrophage polarization shift in adipose tissues. PloS one 30 24236066
2018 Dietary fat-associated osteoarthritic chondrocytes gain resistance to lipotoxicity through PKCK2/STAMP2/FSP27. Bone research 25 30002945
2012 Six-transmembrane epithelial antigen of prostate 4 (STEAP4) is expressed on monocytes/neutrophils, and is regulated by TNF antagonist in patients with rheumatoid arthritis. Clinical and experimental rheumatology 22 22244520
2011 Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1. Molecular medicine reports 22 21468601
2020 Hepatic STAMP2 mediates recombinant FGF21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20 32721044
2012 Hepatic STAMP2 decreases hepatitis B virus X protein-associated metabolic deregulation. Experimental & molecular medicine 20 23095254
2021 Discovery and Pharmacological Evaluation of STEAP4 as a Novel Target for HER2 Overexpressing Breast Cancer. Frontiers in oncology 19 33842315
2018 Cilostazol Improves HFD-Induced Hepatic Steatosis by Upregulating Hepatic STAMP2 Expression through AMPK. Molecular pharmacology 19 30366981
2014 Overexpression of STAMP2 suppresses atherosclerosis and stabilizes plaques in diabetic mice. Journal of cellular and molecular medicine 18 24467451
2014 STEAP4 and insulin resistance. Endocrine 18 24627165
2009 STEAP4 regulates focal adhesion kinase activation and CpG motifs within STEAP4 promoter region are frequently methylated in DU145, human androgen-independent prostate cancer cells. International journal of molecular medicine 18 19787193
2015 Steap4 attenuates high glucose and S100B-induced effects in mesangial cells. Journal of cellular and molecular medicine 17 25817898
2012 Functional analysis and transcriptional regulation of porcine six transmembrane epithelial antigen of prostate 4 (STEAP4) gene and its novel variant in hepatocytes. The international journal of biochemistry & cell biology 17 23262293
2021 STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis. Journal of neuroinflammation 16 33879167
2016 TIARP attenuates autoantibody-mediated arthritis via the suppression of neutrophil migration by reducing CXCL2/CXCR2 and IL-6 expression. Scientific reports 16 27995997
2021 STAMP2 Expression Mediated by Cytokines Attenuates Their Growth-Limiting Effects in Prostate Cancer Cells. Cancers 15 33808059
2023 STEAP4 modulates cell proliferation and oxidative stress in benign prostatic hyperplasia. Cellular signalling 14 37866665
2023 ASH2L upregulation contributes to diabetic endothelial dysfunction in mice through STEAP4-mediated copper uptake. Acta pharmacologica Sinica 14 37903897
2021 Overexpressing STAMP2 attenuates diabetic renal injuries via upregulating autophagy in diabetic rats. Biochemical and biophysical research communications 14 34583195
2020 STEAP4 Inhibits HIF-1α/PKM2 Signaling and Reduces High Glucose-Induced Apoptosis of Retinal Vascular Endothelial Cells. Diabetes, metabolic syndrome and obesity : targets and therapy 14 32765036
2015 Specific overexpression of tumour necrosis factor-α-induced protein (TNFAIP)9 in CD14(+) CD16(-) monocytes in patients with rheumatoid arthritis: comparative analysis with TNFAIP3. Clinical and experimental immunology 14 25683200
2020 The six-transmembrane protein Stamp2 ameliorates pulmonary vascular remodeling and pulmonary hypertension in mice. Basic research in cardiology 13 33188479
2018 Palmitate induces lipoapoptosis in Schwann cells through ROS generation-mediated STAMP2 downregulation. Biochemical and biophysical research communications 13 30005874
2010 Variations of six transmembrane epithelial antigen of prostate 4 (STEAP4) gene are associated with metabolic syndrome in a female Uygur general population. Archives of medical research 13 21044749
2022 STEAP4 promoter methylation correlates with tumorigenesis of hepatocellular carcinoma. Pathology, research and practice 12 35390632
2019 Inflammation and ER stress differentially regulate STAMP2 expression and localization in adipocytes. Metabolism: clinical and experimental 12 30710574
2010 Expression of STAMP2 in monocytes associates with cardiovascular alterations. European journal of clinical investigation 12 20412289
2018 Effect of Omega-3 Fatty Acid on STAMP2 Expression in the Heart and Kidney of 5/6 Nephrectomy Rat Model. Marine drugs 10 30360481
2005 Tumour necrosis factor alpha-induced adipose-related protein (TIARP): co-localization with caveolin-1. Biology of the cell 10 15836432
2019 Treatment with metformin prevents myocardial ischemia-reperfusion injury via STEAP4 signaling pathway. Anatolian journal of cardiology 9 31062756
2017 Overexpressing STAMP2 attenuates adipose tissue angiogenesis and insulin resistance in diabetic ApoE-/- /LDLR-/- mouse via a PPARγ/CD36 pathway. Journal of cellular and molecular medicine 9 28631352
2016 Expression and clinical significance of obesity-associated gene STEAP4 in obese children. Genetics and molecular research : GMR 9 27808366
2017 STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation. Endocrine 7 28405880
2025 Diabetes-Mediated STEAP4 Enhances Retinal Oxidative Stress and Impacts the Development of Diabetic Retinopathy. Antioxidants (Basel, Switzerland) 6 40002391
2025 Lithium Exposure Causes Trophoblast Cuproptosis by Upregulating FOXO1/STEAP4 Axis in Unexplained Miscarriage. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 6 40855689
2023 STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma. Cancer & metabolism 6 38111065
2022 Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-κB pathway. Folia histochemica et cytobiologica 6 36583372
2021 Stamp2 Protects From Maladaptive Structural Remodeling and Systolic Dysfunction in Post-Ischemic Hearts by Attenuating Neutrophil Activation. Frontiers in immunology 6 34691017
2017 Clinical and functional significance of STEAP4-splice variant in CD14+ monocytes in patients with rheumatoid arthritis. Clinical and experimental immunology 6 29080328
2016 STAMP2 is required for human adipose-derived stem cell differentiation and adipocyte-facilitated prostate cancer growth in vivo. Oncotarget 6 29190878
2011 A common variation within the STEAP4 gene exons is associated with obesity in Uygur general population. Chinese medical journal 6 21933608
2022 Hepatic STAMP2 alleviates polychlorinated biphenyl-induced steatosis and hepatic iron overload in NAFLD models. Environmental toxicology 5 35616167
2011 [Genetic variation and association of STEAP4 gene with metabolic syndrome in Chinese Uygur patients]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 5 21287516
2025 Adipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice. iScience 4 39995871
2025 HERP constrains white adipose expansion and inflammation by STEAP4 stabilization. Cell death and differentiation 3 41249464
2024 Forskolin improves experimental autoimmune encephalomyelitis in mice probably by inhibiting the calcium and the IL-17-STEAP4 signaling pathway. Heliyon 3 39229522
2022 STAMP2 suppresses autophagy in prostate cancer cells by modulating the integrated stress response pathway. American journal of cancer research 3 35141021
2022 STAMP2 Attenuates Cardiac Dysfunction and Insulin Resistance in Diabetic Cardiomyopathy via NMRAL1-Mediated NF-κB Inhibition in Type 2 Diabetic Rats. Diabetes, metabolic syndrome and obesity : targets and therapy 3 36276296
2021 The expression of STEAP4 in peripheral blood predicts the outcome of septic patients. Annals of translational medicine 3 34790725
2016 [Monocyte/Macrophage and TNFα-induced adipose related protein (TIARP) in rheumatoid arthritis]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 3 27795502
2012 [Crucial role of TNFα-induced adipose-related protein (TIARP) in the pathogenesis of autoimmune arthritis]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 3 22374443
2011 Association of STEAP4 genetic polymorphisms with insulin resistance in Uygur Chinese general population. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 3 21718614
2025 Enzalutamide-Resistant STEAP4+ MyoCAF Secrete Phosphatidylcholine to Foster Progression by Activating Stemness in Hormone-Sensitive Prostate Cancer. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2 40917018
2024 Chi-circ_0009659 modulates goat intramuscular adipocyte differentiation through miR-3431-5p/STEAP4 axis. Animal bioscience 2 39483024
2022 The Role of STAMP2 in Pathogenesis of Chronic Diseases Focusing on Nonalcoholic Fatty Liver Disease: A Review. Biomedicines 2 36140186
2022 Overexpression of goat STEAP4 promotes the differentiation of subcutaneous adipocytes. Archives animal breeding 2 36415757
2020 Hepatic Steatosis Alleviated in Diabetic Mice upon Dietary Exposure to Fibroin via Transgenic Rice: Potential STAMP2 Involvement in Hepatocytes. Development & reproduction 2 33110955
2016 Expression and clinical significance of the obesity-related gene TNFAIP9 in obese children. Genetics and molecular research : GMR 2 27706555
2009 [The role of TNFalpha-induced adipose-related protein (TIARP) in TNFalpha dependent arthritic model--GPI-induced arthritis]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2 19252373
2009 [Regulative role of TNFalpha on STEAP4 gene in matured human adipocytes]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 2 20113612
2025 STEAP4 facilitates growth, migration, and invasion of prostate carcinoma through upregulation of NOTCH4. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1 40171963
2025 The STEAP4 target NQO1 mediates colon tumorigenesis. Journal of cell science 1 40205952
2025 HDAC2 mediates the activation of macrophage in sepsis induced lung injury via regulating the acetylation of SOX2 and the transcription of STAMP2. European journal of medical research 1 40877891
2025 Cilostazol or canagliflozin mitigates Cyclosporine A-induced nephrotoxicity by modulating the STAMP2-mTOR-AMPK signaling pathway and autophagy in a rat model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 1 41172958
2025 Steap4 Promotes Senile Osteoporosis via Fe2+-ROS/C/EBPβ Feedback-Driven Ferroptosis and Adipogenesis in Senescent BMSCs. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 1 41201016
2025 The GATA3-STEAP4 Axis Drives Inflammation by Promoting Th2 Differentiation in Allergic Rhinitis. Inflammation 1 41422349
2024 Revealing the regulation of allergic asthma airway epithelial cell inflammation by STEAP4 targeting MIF through machine learning algorithms and single-cell sequencing analysis. Frontiers in molecular biosciences 1 39176391
2024 STEAP4 with copper reductase activity suppresses tumorigenesis by regulating the cell cycle in hepatocellular carcinoma cells. Cell division 1 39719623
2011 [Negative association of STAMP2 gene polymorphisms with essential hypertension in Xinjiang Uygur population]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 1 21287513
2026 NAMPT improves high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) via the SIRT1-C/EBPβ-STEAP4-NRF2 axis. Journal of molecular cell biology 0 41324246
2026 Targeting STEAP4 ameliorates pericytes loss and vascular dysfunction in cisplatin induced mouse acute kidney injury. International journal of biological macromolecules 0 41831514
2026 Hepatic STEAP4 promotes liver regeneration by regulating lysosomal iron homeostasis and membrane integrity in acetaminophen-induced liver injury. Hepatology (Baltimore, Md.) 0 41838890
2026 SIRT3 deacetylates STEAP4 to modulate cuproptosis sensitivity via mitochondrial metabolic reprogramming in HBV-related HCC. Cell death and differentiation 0 41840161
2026 STEAP4 Modulates Intestinal Barrier Dysfunction and Inflammatory Signaling Pathways in Ulcerative Colitis. Shock (Augusta, Ga.) 0 41886624
2025 TNFAIP9 protects against the development of the early stage of chronic kidney disease: Focus on inflammation and fibrosis. PloS one 0 40472000
2025 REL/STEAP4 promotes aortic valve calcification by inducing iron overload and ferroptosis in valvular interstitial cells. Free radical biology & medicine 0 41115643
2025 Metalloreductase STEAP4 suppresses TNBC progression via the ROS/NRF2/NOTCH1 signaling axis and is stabilized by lncRNA ENST00000595121. International journal of biological macromolecules 0 41276039
2025 Enhanced STEAP4 Ubiquitination in Obesity: Insights From Combined Proteome and Ubiquitylome Analysis of Visceral Adipose Tissue. Molecular & cellular proteomics : MCP 0 41317904
2024 Tumor Heterogeneity of STEAP4 in Malignant Progression of Oral Squamous Cell Carcinoma. Journal of Cancer 0 39668818

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