ST3GAL4
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 · UniProt Q11206
Audit flag: ungrounded claim
- Length
- 333 aa
- Mass
- 38.0 kDa
- Annotated
- 2026-06-14
100 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 100 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 1994 | STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. | Diabetes | 343 | 7926307 |
| 2019 | Inhibition of STAT3 in tubular epithelial cells prevents kidney fibrosis and nephropathy in STZ-induced diabetic mice. | Cell death & disease | 145 | 31699972 |
| 2010 | Insulin receptor signaling in rat hippocampus: a study in STZ (ICV) induced memory deficit model. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology | 112 | 21195590 |
| 2012 | A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats. | Journal of neuroimmunology | 106 | 23021418 |
| 2016 | Resveratrol ameliorates myocardial fibrosis by inhibiting ROS/ERK/TGF-β/periostin pathway in STZ-induced diabetic mice. | BMC cardiovascular disorders | 105 | 26750922 |
| 2013 | Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells. | PloS one | 105 | 23799130 |
| 2000 | Regulated hepatic insulin gene therapy of STZ-diabetic rats. | Gene therapy | 90 | 11083496 |
| 1994 | The cardiac renin-angiotensin system in STZ-induced diabetes. | Diabetes | 88 | 7926285 |
| 1993 | STZ-induced diabetes results in decreased activity of glomerular cathepsin and metalloprotease in rats. | Diabetes | 78 | 8397128 |
| 2019 | Dulaglutide ameliorates STZ induced AD-like impairment of learning and memory ability by modulating hyperphosphorylation of tau and NFs through GSK3β. | Biochemical and biophysical research communications | 75 | 30773255 |
| 2005 | Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice. | Biochemical and biophysical research communications | 67 | 15652518 |
| 2019 | Antidiabetic effects of pterostilbene through PI3K/Akt signal pathway in high fat diet and STZ-induced diabetic rats. | European journal of pharmacology | 65 | 31283935 |
| 2008 | Chronic angiotensin (1-7) injection accelerates STZ-induced diabetic renal injury. | Acta pharmacologica Sinica | 65 | 18565281 |
| 2019 | Puerarin alleviates streptozotocin (STZ)-induced osteoporosis in rats through suppressing inflammation and apoptosis via HDAC1/HDAC3 signaling. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 62 | 31054509 |
| 1999 | STZ-induced diabetes decreases and insulin normalizes POMC mRNA in arcuate nucleus and pituitary in rats. | The American journal of physiology | 58 | 10233022 |
| 2019 | ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 57 | 31914669 |
| 2014 | Deficiency of the sialyltransferase St3Gal4 reduces Ccl5-mediated myeloid cell recruitment and arrest: short communication. | Circulation research | 56 | 24425712 |
| 2012 | Intracerebroventricular administration of an insulin analogue recovers STZ-induced cognitive decline in rats. | Behavioural brain research | 56 | 23238038 |
| 2011 | ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor. | Behavioural brain research | 56 | 21620901 |
| 2016 | Intranasal insulin improves cerebral blood flow, Nrf-2 expression and BDNF in STZ (ICV)-induced memory impaired rats. | Life sciences | 54 | 27693383 |
| 2013 | Telmisartan ameliorates germ cell toxicity in the STZ-induced diabetic rat: studies on possible molecular mechanisms. | Mutation research | 53 | 23648321 |
| 2014 | Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway. | Food & function | 51 | 24595557 |
| 2020 | Mefunidone ameliorates diabetic kidney disease in STZ and db/db mice. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 50 | 33225469 |
| 2017 | Apigenin alleviates STZ-induced diabetic cardiomyopathy. | Molecular and cellular biochemistry | 46 | 28176247 |
| 2016 | Lentinan protects pancreatic β cells from STZ-induced damage. | Journal of cellular and molecular medicine | 46 | 27444655 |
| 2019 | Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis. | Physiology & behavior | 44 | 31669775 |
| 2018 | Cinnamaldehyde ameliorates STZ-induced rat diabetes through modulation of IRS1/PI3K/AKT2 pathway and AGEs/RAGE interaction. | Naunyn-Schmiedeberg's archives of pharmacology | 43 | 30460386 |
| 2013 | Inhibition of MAPK-mediated ACE expression by compound C66 prevents STZ-induced diabetic nephropathy. | Journal of cellular and molecular medicine | 42 | 24330074 |
| 2011 | Thyroid hormone T3 counteracts STZ induced diabetes in mouse. | PloS one | 40 | 21637761 |
| 2020 | Phycocyanin alleviates ICV-STZ induced cognitive and molecular deficits via PI3-Kinase dependent pathway. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association | 39 | 32805344 |
| 2018 | Profile of cardiac lipid metabolism in STZ-induced diabetic mice. | Lipids in health and disease | 39 | 30301464 |
| 2015 | Assessment of the coordinated role of ST3GAL3, ST3GAL4 and ST3GAL6 on the α2,3 sialylation linkage of mammalian glycoproteins. | Biochemical and biophysical research communications | 39 | 25998389 |
| 2013 | Expression of the sialyltransferase, ST3Gal4, impacts cardiac voltage-gated sodium channel activity, refractory period and ventricular conduction. | Journal of molecular and cellular cardiology | 39 | 23471032 |
| 2021 | The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice. | Scientific reports | 38 | 34294853 |
| 2016 | Novel hydrogen sulfide-releasing compound, S-propargyl-cysteine, prevents STZ-induced diabetic nephropathy. | Biochemical and biophysical research communications | 38 | 27055593 |
| 2021 | Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499-5p/APC axis. | Journal of pharmacological sciences | 37 | 33858650 |
| 2021 | Albiflorin alleviates cognitive dysfunction in STZ-induced rats. | Aging | 37 | 34319254 |
| 2003 | Molecular epidemiology of SAT3-type foot-and-mouth disease. | Virus genes | 37 | 14618089 |
| 2016 | Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice. | Diabetes | 35 | 27284107 |
| 2016 | Peripheral Levels of AGEs and Astrocyte Alterations in the Hippocampus of STZ-Diabetic Rats. | Neurochemical research | 33 | 27084774 |
| 2008 | 17beta-Estradiol and/or progesterone protect from insulin resistance in STZ-induced diabetic rats. | The Journal of steroid biochemistry and molecular biology | 32 | 18657616 |
| 2000 | Impaired beta-cell regeneration in perinatally malnourished rats: a study with STZ. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 32 | 11099480 |
| 2018 | CAPE-pNO2 attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 31 | 30372866 |
| 2018 | Inhibiting the urokinase-type plasminogen activator receptor system recovers STZ-induced diabetic nephropathy. | Journal of cellular and molecular medicine | 31 | 30426662 |
| 2021 | Chrysin ameliorates STZ-induced diabetes in rats: possible impact of modulation of TLR4/NF-κβ pathway. | Research in pharmaceutical sciences | 29 | 34909039 |
| 2021 | Indomethacin attenuates neuroinflammation and memory impairment in an STZ-induced model of Alzheimer's like disease. | Immunopharmacology and immunotoxicology | 28 | 34585992 |
| 2001 | Retinal glial cell immunoreactivity and neuronal cell changes in rats with STZ-induced diabetes. | Current eye research | 28 | 11852429 |
| 2015 | Beta-cell regeneration from vimentin+/MafB+ cells after STZ-induced extreme beta-cell ablation. | Scientific reports | 27 | 26129776 |
| 2018 | p38-MAPK pathway is activated in retinopathy of microvascular disease of STZ-induced diabetic rat model. | European review for medical and pharmacological sciences | 26 | 30280757 |
| 2012 | TNF regulates sialyl-Lewisx and 6-sulfo-sialyl-Lewisx expression in human lung through up-regulation of ST3GAL4 transcript isoform BX. | Biochimie | 26 | 22691873 |
| 2008 | Effects of streptozotocin (STZ)-induced diabetes and insulin replacement on rat ventral prostate. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 26 | 18313883 |
| 2005 | Expression changes of thrombospondin-1 and neuropeptide Y in myocardium of STZ-induced rats. | International journal of cardiology | 26 | 16243112 |
| 2022 | Single-cell RNA-Seq analysis of diabetic wound macrophages in STZ-induced mice. | Journal of cell communication and signaling | 25 | 36445632 |
| 2019 | Cannabinoid Receptor Type 1 Agonist ACEA Improves Cognitive Deficit on STZ-Induced Neurotoxicity Through Apoptosis Pathway and NO Modulation. | Neurotoxicity research | 25 | 30607903 |
| 2016 | Effect of HFD/STZ on expression of genes involved in lipid, cholesterol and glucose metabolism in rats. | Life sciences | 25 | 27693527 |
| 2017 | Zanthoxylum alkylamides ameliorate protein metabolism disorder in STZ-induced diabetic rats. | Journal of molecular endocrinology | 24 | 28100702 |
| 2024 | Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer. | Cancer letters | 23 | 38408602 |
| 2019 | Tanshinone IIA ameliorates diabetic cardiomyopathy by inhibiting Grp78 and CHOP expression in STZ-induced diabetes rats. | Experimental and therapeutic medicine | 23 | 31258708 |
| 2018 | 5-HT6 receptor agonist and antagonist modulates ICV-STZ-induced memory impairment in rats. | Psychopharmacology | 23 | 29502275 |
| 2018 | IL-33 Prevents MLD-STZ Induction of Diabetes and Attenuate Insulitis in Prediabetic NOD Mice. | Frontiers in immunology | 23 | 30498495 |
| 2024 | STZ-induced diabetes exacerbates neurons ferroptosis after ischemic stroke by upregulating LCN2 in neutrophils. | Experimental neurology | 21 | 38670252 |
| 2021 | P2X7 Receptor Deficiency Ameliorates STZ-induced Cardiac Damage and Remodeling Through PKCβ and ERK. | Frontiers in cell and developmental biology | 21 | 34395424 |
| 2020 | Antidiabetic effect of a flavonoid-rich extract from Sophora alopecuroides L. in HFD- and STZ- induced diabetic mice through PKC/GLUT4 pathway and regulating PPARα and PPARγ expression. | Journal of ethnopharmacology | 21 | 33271248 |
| 2021 | Rab11-mediated post-Golgi transport of the sialyltransferase ST3GAL4 suggests a new mechanism for regulating glycosylation. | The Journal of biological chemistry | 20 | 33524390 |
| 2024 | The glycosyltransferase ST3GAL4 drives immune evasion in acute myeloid leukemia by synthesizing ligands for the glyco-immune checkpoint receptor Siglec-9. | Leukemia | 19 | 39551873 |
| 2023 | Mulberry extract ameliorates T2DM-related symptoms via AMPK pathway in STZ-HFD-induced C57BL/6J mice. | Journal of ethnopharmacology | 19 | 37120060 |
| 2022 | Preclinical anti-inflammatory and antioxidant effects of Azanza garckeana in STZ-induced glycemic-impaired rats, and pharmacoinformatics of it major phytoconstituents. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 19 | 35667233 |
| 2021 | Isoliquiritigenin attenuates inflammation and modulates Nrf2/caspase-3 signalling in STZ-induced aortic injury. | The Journal of pharmacy and pharmacology | 19 | 33793806 |
| 2021 | Melatonin attenuates aortic oxidative stress injury and apoptosis in STZ-diabetes rats by Notch1/Hes1 pathway. | The Journal of steroid biochemistry and molecular biology | 19 | 34224859 |
| 2018 | SIRT1 activation attenuates α cell hyperplasia, hyperglucagonaemia and hyperglycaemia in STZ-diabetic mice. | Scientific reports | 19 | 30228292 |
| 2016 | RNA sequencing reveals retinal transcriptome changes in STZ-induced diabetic rats. | Molecular medicine reports | 19 | 26781437 |
| 2013 | Effects of thymoquinone on STZ-induced diabetic nephropathy: an immunohistochemical study. | Ultrastructural pathology | 19 | 24134725 |
| 2021 | GYY4137 attenuates functional impairment of corpus cavernosum and reduces fibrosis in rats with STZ-induced diabetes by inhibiting the TGF-β1/Smad/CTGF pathway. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 18 | 34311523 |
| 2020 | Lentivirus Mediated Pancreatic Beta-Cell-Specific Insulin Gene Therapy for STZ-Induced Diabetes. | Molecular therapy : the journal of the American Society of Gene Therapy | 18 | 33130311 |
| 2018 | NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance. | Journal of Alzheimer's disease : JAD | 18 | 30149447 |
| 2014 | IL-32γ overexpression accelerates streptozotocin (STZ)-induced type 1 diabetes. | Cytokine | 18 | 25022955 |
| 2022 | Oral Nanocurcumin Alone or in Combination with Insulin Alleviates STZ-Induced Diabetic Neuropathy in Rats. | Molecular pharmaceutics | 17 | 36106748 |
| 2017 | Ghrelin ameliorates nerve growth factor Dysmetabolism and inflammation in STZ-induced diabetic rats. | Metabolic brain disease | 17 | 28357639 |
| 2022 | Chrysin improves diabetic nephropathy by regulating the AMPK-mediated lipid metabolism in HFD/STZ-induced DN mice. | Journal of food biochemistry | 16 | 35976957 |
| 2021 | CMAS and ST3GAL4 Play an Important Role in the Adsorption of Influenza Virus by Affecting the Synthesis of Sialic Acid Receptors. | International journal of molecular sciences | 16 | 34200006 |
| 2020 | Palbinone alleviates diabetic retinopathy in STZ-induced rats by inhibiting NLRP3 inflammatory activity. | Journal of biochemical and molecular toxicology | 16 | 32202043 |
| 2020 | Hirudin reduces nephropathy microangiopathy in STZ-induced diabetes rats by inhibiting endothelial cell migration and angiogenesis. | Life sciences | 16 | 32417374 |
| 2020 | Shenzhiling Oral Liquid Protects STZ-Injured Oligodendrocyte through PI3K/Akt-mTOR Pathway. | Evidence-based complementary and alternative medicine : eCAM | 16 | 32774416 |
| 2020 | A proteoglycan extract from Ganoderma Lucidum protects pancreatic beta-cells against STZ-induced apoptosis. | Bioscience, biotechnology, and biochemistry | 16 | 32799731 |
| 2009 | DNA vaccine containing the mycobacterial hsp65 gene prevented insulitis in MLD-STZ diabetes. | Journal of immune based therapies and vaccines | 16 | 19754943 |
| 2023 | Effect of Selenium Nanoparticles and/or Bee Venom against STZ-Induced Diabetic Cardiomyopathy and Nephropathy. | Metabolites | 15 | 36984840 |
| 2022 | Integrated Metabolomics and Transcriptomics Reveal Metabolic Patterns in Retina of STZ-Induced Diabetic Retinopathy Mouse Model. | Metabolites | 15 | 36557283 |
| 2021 | The ameliorative effect of bromelain on STZ-induced type 1 diabetes in rats through Oxi-LDL/LPA/LPAR1 pathway. | Life sciences | 15 | 34592232 |
| 2020 | Morin attenuates STZ-induced diabetic retinopathy in experimental animals. | Saudi journal of biological sciences | 15 | 32714041 |
| 2020 | Tropisetron attenuates pancreas apoptosis in the STZ-induced diabetic rats: involvement of SIRT1/NF-κB signaling. | Pharmacological reports : PR | 15 | 32725585 |
| 2008 | Characterization of STZ-Induced Type 2 Diabetes in Zucker Fatty Rats. | Experimental animals | 15 | 18633156 |
| 2024 | Exploring dose-response variability and relative severity assessment in STZ-induced diabetes male NSG mice. | Scientific reports | 14 | 39020093 |
| 2023 | Anti-diabetic mechanism and potential bioactive peptides of casein hydrolysates in STZ/HFD-induced diabetic rats. | Journal of the science of food and agriculture | 14 | 38041433 |
| 2022 | The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide. | Nutrition & diabetes | 14 | 35725834 |
| 2022 | Evaluation of curcumin effect on Il6, Sirt1, TNFα and NFkB expression of liver tissues in diabetic mice with STZ. | Journal of diabetes and metabolic disorders | 14 | 37255806 |
| 2021 | Palmatine Inhibits Up-Regulation of GRP78 and CALR Protein in an STZ-Induced Diabetic Rat Model. | Current pharmaceutical biotechnology | 14 | 32744968 |
| 2019 | RNA-Seq analysis of the pathogenesis of STZ-induced male diabetic mouse liver. | Journal of diabetes and its complications | 14 | 31757765 |
| 2023 | Exercise mitigates Dapagliflozin-induced skeletal muscle atrophy in STZ-induced diabetic rats. | Diabetology & metabolic syndrome | 13 | 37438792 |
| 2019 | Inherent biophysical stability of foot-and-mouth disease SAT1, SAT2 and SAT3 viruses. | Virus research | 13 | 30807778 |
| 2016 | Glycomic and sialoproteomic data of gastric carcinoma cells overexpressing ST3GAL4. | Data in brief | 13 | 27077082 |
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