Affinage

SOX7

Transcription factor SOX-7 · UniProt Q9BT81

Length
388 aa
Mass
42.2 kDa
Annotated
2026-04-28
100 papers in source corpus 39 papers cited in narrative 40 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SOX7 is a SoxF-family HMG-box transcription factor that governs endothelial cell identity, arteriovenous specification, cardiovascular morphogenesis, and the endothelial-to-hematopoietic transition, while also acting as a context-dependent tumor suppressor. SOX7 binds SOX consensus motifs via its HMG box to directly activate endothelial genes (VE-cadherin, VEGFR2) and repress targets such as VEGFC, PSMA, and DNMT3B, and it physically interacts with β-catenin to suppress Wnt/β-catenin transcription by competing with BCL9 and disrupting TCF4-mediated gene activation (PMID:18819930, PMID:29271667, PMID:23295859). In vascular development, SOX7 functions redundantly with SOX17 and SOX18 to establish arterial identity and pattern lymphatic vessels, acting upstream of Notch signaling, and its endothelial-specific deletion causes arteriovenous malformations, coronary artery defects, and ventricular non-compaction (PMID:18094332, PMID:25834021, PMID:37551717, PMID:36715213). SOX7 also directly interacts with RUNX1 to block the haemogenic endothelium-to-blood transition, interacts with GATA4 to balance endothelial versus cardiac progenitor fate, and regulates Wnt4/Bmp2 signaling in atrioventricular cushion development; loss-of-function SOX7 mutations co-segregate with congenital heart disease (PMID:27802172, PMID:31154937, PMID:33846290, PMID:35422912).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2001 Medium

    Identifying SOX7 as a transcription factor with an intrinsic transactivation domain that can repress Wnt/β-catenin signaling established its dual capacity as activator and repressor.

    Evidence Transactivation domain mapping and Wnt reporter assays

    PMID:11691915

    Open questions at the time
    • Mechanism of Wnt repression not defined at the protein-interaction level
    • No endogenous target genes identified
  2. 2004 High

    Demonstration that SOX7 directly binds DNA at SOX sites to activate Lama1 and Fgf-3 promoters, and that it acts upstream of GATA-4/GATA-6 in parietal endoderm differentiation, defined its earliest transcriptional targets and placed it in an endoderm differentiation hierarchy.

    Evidence EMSA, mutagenesis, reporter assays, siRNA knockdown in F9 cells with rescue by GATA factors

    PMID:15082719 PMID:15220343 PMID:15542856

    Open questions at the time
    • Genome-wide binding profile not yet determined
    • In vivo relevance in mouse embryos not tested
  3. 2005 High

    Showing that SOX7 and SOX18 redundantly drive cardiogenesis in Xenopus through a β-catenin-independent mechanism revealed that SOX7's transcriptional activator function, not just Wnt antagonism, underlies heart development.

    Evidence Morpholino knockdown and domain-swap mutant injection in Xenopus animal cap explants

    PMID:16193513

    Open questions at the time
    • Mammalian cardiogenic function not yet confirmed
    • Direct cardiac target genes unknown
  4. 2007 High

    Discovery that combined loss of sox7 and sox18 in zebrafish causes arteriovenous fusions established that SoxF factors are collectively essential for arteriovenous specification while individually redundant.

    Evidence Morpholino double knockdown in zebrafish with arterial/venous marker analysis

    PMID:18094332 PMID:18377889

    Open questions at the time
    • Direct transcriptional targets mediating arteriovenous identity not identified
    • Mechanism of venous repression unclear
  5. 2008 High

    Physical interaction between SOX7 and β-catenin, combined with SOX7 promoter hypermethylation in cancers, provided the first mechanistic basis for SOX7 as a Wnt pathway antagonist and tumor suppressor.

    Evidence Co-immunoprecipitation, bisulfite sequencing, colony formation assays in colorectal cancer cells

    PMID:18819930

    Open questions at the time
    • Precise binding interface on β-catenin not mapped
    • In vivo tumor suppression not demonstrated
  6. 2009 High

    Functional substitution experiments showed Sox7 can replace Sox18 in lymphatic development, and enforced Sox7 expression in hematopoietic progenitors blocks differentiation while maintaining multipotency, defining its roles in lymphatic and hematopoietic fate.

    Evidence Cross-strain genetic analysis in mice; inducible overexpression and siRNA in ES cell hematopoietic differentiation

    PMID:19515696 PMID:19801444

    Open questions at the time
    • Direct transcriptional targets in hematopoietic progenitors not identified
    • Mechanism by which Sox7 maintains multipotency unknown
  7. 2012 High

    ChIP-confirmed direct binding of SOX7 to the VE-cadherin promoter in haemogenic endothelium, plus SOX7 knockout lethality with cardiovascular failure, established SOX7 as a direct transcriptional regulator of endothelial identity essential for vascular development.

    Evidence ChIP and reporter assays in ES-derived haemogenic endothelium; targeted gene deletion in mouse with embryonic lethal phenotype

    PMID:22492353 PMID:22723016

    Open questions at the time
    • Genome-wide ChIP-Seq targets not yet mapped
    • Relationship between VE-cadherin activation and vascular remodeling failure not resolved
  8. 2012 High

    Showing SOX7 interacts with both β-catenin and TCF4 and suppresses Wnt target genes Cyclin D1 and c-Myc extended the Wnt antagonism mechanism to include disruption of the β-catenin/TCF transcription complex.

    Evidence Co-immunoprecipitation, immunofluorescence colocalization, reporter assays in endometrial cancer cells

    PMID:23295859

    Open questions at the time
    • Whether SOX7 displaces TCF4 from DNA or forms a ternary inhibitory complex not resolved
  9. 2015 High

    Genetic epistasis placing sox7 upstream of Notch (hey2, efnb2) in zebrafish arterial specification, and triple SoxF deletion causing near-complete loss of retinal arteries and veins, defined the pathway hierarchy and full extent of SoxF redundancy in vascular patterning.

    Evidence Zebrafish genetic mutants with NICD rescue; conditional triple knockout in mouse retinal endothelium

    PMID:25834021 PMID:26630461

    Open questions at the time
    • Whether SOX7 directly activates Notch ligand/receptor transcription or acts indirectly not resolved
    • Mechanisms of reciprocal transcriptional regulation between Sox7 and Sox17 unclear
  10. 2015 High

    Domain deletion showing that the β-catenin binding site in SOX7 is required for anti-leukemia effects, and xenograft validation, provided the first in vivo evidence that Wnt antagonism is the primary tumor-suppressive mechanism of SOX7 in AML.

    Evidence Co-IP with domain deletion mutant, xenograft transplantation in AML

    PMID:25940713

    Open questions at the time
    • Endogenous AML target genes downstream of SOX7-mediated Wnt suppression not identified
  11. 2016 High

    Discovery that SOX7 physically binds RUNX1, prevents RUNX1-CBFβ complex formation, and thereby blocks the haemogenic endothelium-to-blood transition revealed a protein-protein interaction mechanism distinct from SOX7's DNA-binding function.

    Evidence Co-immunoprecipitation, ChIP, single-cell expression profiling in yolk sac

    PMID:27802172

    Open questions at the time
    • Structural basis of SOX7-RUNX1 interaction not determined
    • Whether SOX7 also directly represses RUNX1 target genes via DNA binding unknown
  12. 2017 High

    Multiple studies refined SOX7's mechanism: competition with BCL9 for β-catenin binding explained Wnt antagonism specificity; ChIP-Seq/ATAC-Seq mapped genome-wide targets and confirmed SOX7-GATA4 protein interaction in cardiovascular progenitor fate; and direct repression of PSMA enhancer was mapped to specific SOX box sites.

    Evidence Co-IP for BCL9 competition; ChIP-Seq, ATAC-Seq, and transcriptomics in cardiovascular progenitors; ChIP and EMSA at PSMA enhancer

    PMID:29271667 PMID:30488457 PMID:31154937

    Open questions at the time
    • Structural model of SOX7-β-catenin-BCL9 competition not available
    • How SOX7-GATA4 interaction partitions target gene sets not fully resolved
  13. 2019 High

    Conditional knockout in PAX3+ cells demonstrated SOX7 is required for muscle satellite cell maintenance and myoblast fusion, extending its function beyond endothelium to skeletal muscle stem cells.

    Evidence Conditional PAX3-Cre knockout mouse with satellite cell quantification, injury-regeneration assay, primary myoblast culture

    PMID:28943254

    Open questions at the time
    • Direct transcriptional targets in satellite cells not identified
    • Relationship to Wnt or Notch pathways in this context not tested
  14. 2021 High

    Identification of Wnt4 and Bmp2 as direct SOX7 targets in atrioventricular cushion development, with BMP2 acting downstream of WNT4, defined the signaling cascade by which SOX7 controls endothelial-to-mesenchymal transition in heart valve formation.

    Evidence Conditional knockout mouse, ChIP at Wnt4 and Bmp2 promoters, protein rescue and Noggin inhibition

    PMID:33846290

    Open questions at the time
    • Whether this Wnt4-Bmp2 axis operates in other SOX7-dependent developmental contexts unknown
  15. 2023 High

    Discovery that SOX7 in blood vascular endothelium non-cell-autonomously patterns lymphatic vessels by repressing VEGFC via recruitment of HEY1 to distant regulatory regions revealed a novel mechanism linking SOX7 to Notch effector-mediated transcriptional repression.

    Evidence Conditional loss-of-function in mice, identification of distant VEGFC regulatory regions, Co-IP for SOX7-HEY1 interaction

    PMID:36715213

    Open questions at the time
    • Whether HEY1 recruitment is the sole mechanism of VEGFC repression not established
    • Genome-wide extent of SOX7-HEY1 co-regulation unknown
  16. 2023 High

    Single-nucleus transcriptomics after endothelial Sox7 loss revealed dysregulated Notch pathway genes and connexins 37/40 in coronary endothelium, and fate mapping showed transdifferentiation of Sox7-null endothelial cells into hematopoietic lineages, unifying SOX7's roles in arterial specification, coronary development, and endothelial-hematopoietic fate restriction.

    Evidence Endothelial-specific conditional knockout with single-nuclei transcriptomics and fate mapping

    PMID:37551717

    Open questions at the time
    • Mechanistic link between connexin downregulation and non-compaction phenotype not established
    • Whether transdifferentiation occurs via de-repression of RUNX1 pathway not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis of SOX7's protein-protein interactions (with β-catenin, RUNX1, GATA4, HEY1) remains unresolved, and it is unknown how SOX7 integrates its activator and repressor functions at distinct genomic loci in a cell-type-specific manner.
  • No crystal or cryo-EM structure of SOX7 or its complexes
  • Cell-type-specific chromatin context determining activation versus repression not defined
  • Post-translational regulation of SOX7 activity largely unexplored

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 11 GO:0003677 DNA binding 8 GO:0098772 molecular function regulator activity 5
Localization
GO:0005634 nucleus 2
Pathway
R-HSA-1266738 Developmental Biology 10 R-HSA-74160 Gene expression (Transcription) 9
Partners
BCL9CTNNB1GATA4HEY1NKX2-5RUNX1SOX17TCF4

Evidence

Reading pass · 40 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 SOX7 protein contains a functional transactivation domain in its C-terminus and can significantly reduce Wnt/β-catenin-stimulated transcription, indicating it acts as a repressor of Wnt signaling. Transactivation domain mapping; reporter assay for Wnt/β-catenin transcription Nucleic acids research Medium 11691915
2004 SOX7 and SOX17 bind to two SOX-binding sites within the parietal endoderm-specific enhancer of the mouse laminin alpha1 (Lama1) gene via their HMG boxes, and synergistically transactivate this enhancer in cooperation with ubiquitous factors Sp1/Sp3 and NF-Y. EMSA, mutational analysis, luciferase reporter assay, Northern blot The Journal of biological chemistry High 15220343
2004 SOX7 is a potent transcriptional activator of Fgf-3 through binding to the PS4A regulatory element of the Fgf-3 promoter; SOX7 competes with GATA-4 for PS4A occupancy, and siRNA-mediated knockdown of Sox7 abolishes Fgf-3 expression in GATA-4-deficient embryoid bodies. Luciferase reporter assay, nuclear extract binding, RNA interference, in situ hybridization The Journal of biological chemistry High 15082719
2004 Sox7 silencing in F9 embryonal carcinoma cells inhibits retinoic acid/cAMP-induced upregulation of Gata-4 and Gata-6, and inhibits parietal endoderm differentiation; Sox7 acts upstream of Gata-4 and Gata-6, and overexpression of either GATA factor rescues differentiation in Sox7-silenced cells. siRNA knockdown, Western blot, morphological analysis, laminin-1 production assay, rescue overexpression Molecular and cellular biology High 15542856
2005 In Xenopus, SOX7 and SOX18 are redundantly required for cardiogenesis; versions of SOX7 and SOX18 with their C-terminal β-catenin interaction domains replaced by a transcriptional activator still induce cardiogenesis, indicating the cardiogenic function is independent of β-catenin antagonism. Morpholino knockdown, RNA overexpression, domain-swap mutant injection, animal cap explant assay Developmental dynamics High 16193513
2007 Zebrafish sox7 and sox18 play redundant but collectively essential roles in establishing arteriovenous identity in endothelial cells; simultaneous morpholino knockdown of both genes causes multiple arteriovenous fusions with failure of venous endothelial cell differentiation, while endothelial cell specification is preserved. Morpholino knockdown, transgenic reporter lines, in situ hybridization for arterial/venous markers Blood High 18094332
2008 Zebrafish Sox7 and Sox18 control arterial-venous identity by regulating Gridlock expression; loss of both genes causes ectopic expression of venous marker Flt4 in the dorsal aorta and loss of artery-specific markers EphrinB2a and Gridlock. Morpholino double knockdown, in situ hybridization, transgenic reporter lines Developmental biology High 18377889
2008 SOX7 protein physically interacts with β-catenin and suppresses β-catenin-mediated transcription by depleting active β-catenin; Sox7 promoter is hypermethylated in prostate and colorectal cancers, and ectopic SOX7 suppresses proliferation in colorectal cancer cells with endogenous mutant β-catenin. Co-immunoprecipitation, reporter assay, bisulfite sequencing, cell proliferation/colony formation assays Molecular cancer research High 18819930
2009 Sox7 and Sox17 are strain-specific modifiers that can functionally substitute for Sox18 in lymphatic development in vitro and in vivo; they are not normally expressed during lymphatic development but are specifically upregulated in the absence of Sox18 function in permissive strains. In vitro functional substitution assay, in vivo genetic analysis across mouse strains, gene expression analysis Development High 19515696
2009 Sox7 sustained expression in earliest committed hematopoietic precursors (from mouse ES cell differentiation) promotes maintenance of multipotent, self-renewing status and blocks differentiation; removal of this block permits efficient differentiation to erythroid and myeloid lineages. Sox7 knockdown decreases formation of primitive erythroid and definitive hematopoietic progenitors. Inducible overexpression, siRNA knockdown, ES cell differentiation assay, colony forming assay Blood High 19801444
2009 Sox7 and Sox15 both upregulate muscle precursor markers Pax3/7, Meox1, and Foxc1 in P19 cells, but only Sox7 is sufficient to drive full skeletal myocyte differentiation; Sox15 blocks progression past the precursor stage through sustained Msx1 and Id1 expression. Stable overexpression in P19 cells, qRT-PCR, immunofluorescence for myogenic markers, dominant-negative analysis Stem cells Medium 19489079
2012 SOX7 is expressed in haemogenic endothelium cells during haemangioblast differentiation and its enforced expression blocks further differentiation toward blood precursors while sustaining endothelial markers; SOX7 directly binds and activates the promoter of VE-cadherin, identifying it as a transcriptional target. Gain-of-function in mouse ES cell differentiation, chromatin immunoprecipitation (ChIP), promoter-reporter assay, flow cytometry Development High 22492353
2012 Sox7 haploinsufficiency in mice causes anterior diaphragmatic hernias; SOX7 is expressed in vascular endothelial cells of the developing diaphragm. Complete Sox7 knockout leads to embryonic lethality with dilated pericardial sacs and failure of yolk sac remodeling indicating cardiovascular failure. Targeted gene deletion (exon 2), immunohistochemistry, phenotypic analysis Human molecular genetics High 22723016
2014 ETV2 is a direct upstream transcriptional regulator of Sox7; ETV2 binds to ETV2 binding elements in the Sox7 upstream regulatory region and activates transcription. SOX7 overexpression mimics ETV2 in promoting endothelial progenitor cell formation and angiogenic sprouting, while Sox7 knockdown blocks ETV2-induced endothelial progenitor increases. ChIP of ETV2 at Sox7 regulatory region, reporter assay, overexpression and shRNA knockdown in embryoid bodies Stem cells and development High 24762086
2015 Combined deletion of Sox7, Sox17, and Sox18 in mouse retinal vascular endothelium leads to a dense capillary plexus with near-complete loss of radial arteries and veins; individual deletions have minimal effect due to overlapping function and reciprocal transcriptional regulation between Sox7 and Sox17. Conditional endothelial-specific gene deletion, retinal flatmount analysis, vascular smooth muscle cell coverage assay PloS one High 26630461
2015 In zebrafish, sox7 mutants display aberrant arteriovenous connections and arterial block; genetic interaction studies show sox7 works with hey2 and efnb2 for arterial specification, and overexpression of Notch intracellular domain rescues the sox7 mutant phenotype, placing Sox7 upstream of Notch in arterial development. Zebrafish genetic mutants, in vivo imaging, in situ hybridization, genetic epistasis/rescue with NICD overexpression Development High 25834021
2015 SOX7 directly binds β-catenin protein and inhibits Wnt/β-catenin transcriptional activity in AML cells; deletion of the β-catenin binding site in SOX7 significantly reduces its anti-leukemia effects, and SOX7 expression abrogates leukemia engraftment in xenograft transplantation. Co-immunoprecipitation, domain deletion mutant, xenograft transplantation, reporter assay Blood High 25940713
2016 SOX7 directly interacts with RUNX1 and inhibits its transcriptional activity by hindering RUNX1 DNA binding and blocking the interaction between RUNX1 and its co-factor CBFβ; this mechanism regulates hemogenic endothelium differentiation in the yolk sac. Co-immunoprecipitation, ChIP, single-cell expression profiling, immunofluorescence Development High 27802172
2016 SOX7 acts as a transcription factor to upregulate IL-33 in pericytes upon PDGF-BB stimulation; IL-33 is the highest upregulated gene following SOX7 activation, and this IL-33-ST2-dependent pathway promotes macrophage recruitment and cancer metastasis. Gain- and loss-of-function experiments, gene expression analysis, pharmacological inhibition of IL-33-ST2, xenograft mouse models Nature communications Medium 27150562
2016 Sox7 in tumor endothelial cells promotes VEGFR2 expression and vascular abnormality in high-grade glioma; Sox7 deletion suppressed VEGFR2 expression, while Sox17 deletion exacerbated abnormality by up-regulating Sox7. Endothelial conditional deletion, in vivo imaging, immunofluorescence, gene expression analysis The Journal of experimental medicine High 29444818
2017 SOX7 directly binds to the VE-cadherin gene promoter and up-regulates its expression in endothelial cells, thereby suppressing endothelial-to-mesenchymal transition (EndMT); luciferase and EMSA confirmed direct promoter binding, and VE-cadherin knockdown partly reverses SOX7-mediated repression of EndMT. Luciferase reporter assay, EMSA, collagen gel culture system, VE-cadherin knockdown rescue Clinical science High 33720353
2017 Sox7 is expressed in FLK1+ endothelial progenitors and its conditional deletion in FLK1+ cells leads to widespread vascular defects by E10.5 including disorganized endothelial cords instead of paired dorsal aorta; hematopoietic-specific (VAV-cre) deletion of Sox7 does not affect the hematopoietic system. FLK1-specific conditional knockout, VAV-specific conditional knockout, histological analysis of embryos from E7.5 to E10.5 Mechanisms of development High 28577909
2017 GATA4 specifically regulates Sox7 and Sox18 expression during cardiomyogenesis; knockdown of Gata4 reduces Sox7/Sox18 expression, and reinstating Sox7 or Sox18 partially rescues cardiomyocyte differentiation lost upon Gata4 knockdown; this axis is conserved between Xenopus and mouse ESCs. Genome-wide transcriptomics, morpholino knockdown, RNA rescue experiments, mouse ESC knockdown Developmental biology High 29229250
2017 SOX7 suppresses Wnt signaling by competing with BCL9 for binding to β-catenin; co-immunoprecipitation showed SOX7 binds β-catenin and disrupts the β-catenin/BCL9 interaction, thereby inhibiting β-catenin/TCF-mediated transcription. Co-immunoprecipitation, super TopFlash reporter assay DNA and cell biology Medium 29271667
2017 Sox7 regulates Sox7 expression in endothelial cells via ETS factor ETV2; Sox7 is required for endothelial cell VEGFR2 expression, angiogenic sprouting from embryoid bodies, and cardiovascular development. Inducible expression, ChIP at Sox7 regulatory region, shRNA knockdown in EBs Stem cells and development High 24762086
2017 Sox7 directly represses PSMA/FOLH1 expression by binding to SOX box sites #2 and #4 within the PSMA enhancer (PSME); the nuclear localization signal (NLS) regions of SOX7, but not its β-catenin-interacting motif, are essential for this suppressive activity. ChIP, EMSA, luciferase reporter assay, Sox7 NLS mutant, stable expression in prostate cancer cells The Prostate High 30488457
2017 SOX7 is identified as a transcriptional repressor of the Hepatitis B virus core promoter (HBVCP); SOX7 binds specifically to the HBVCP via its HMG box and competitively displaces hepatocyte nuclear factor 4α, inhibiting pgRNA synthesis, HBcAg and cccDNA accumulation. EMSA, luciferase reporter assay, HBV replicon and infection models, stapled peptide experiments Journal of hepatology High 28887167
2018 SOX7 induces cellular apoptosis through upregulation of P38 and apoptotic signaling pathway genes and prevents proteasome-mediated degradation of pro-apoptotic protein BIM; treatment with proteasome inhibitor MG132/bortezomib or p-ERK/MEK inhibitor U0126 attenuates SOX7-promoted BIM degradation. Gene expression profiling, pharmacological inhibition (MG132, bortezomib, U0126), Western blot, loss-of-function Oncogene Medium 31332289
2018 SOX7 validated target genes in breast cancer cells include SPRY1 and SLIT2 (SOX7-activated) and TRIB3 and MTHFD2 (SOX7-repressed); these were identified by microarray combined with ChIP validation and confirmed to differentially contribute to tumor suppression. Microarray gene expression profiling, ChIP assay, qPCR validation International journal of molecular sciences Medium 29757932
2019 SOX7 is required for muscle satellite cell development and maintenance; conditional knockout of Sox7 in PAX3+ cells reduces satellite cell population from birth, reduces myofiber caliber, impairs regeneration after injury, and increases sensitivity to apoptosis; SOX7-deficient primary myoblasts show impaired myoblast fusion. Conditional PAX3-Cre knockout mouse, satellite cell quantification, injury-induced regeneration assay, primary myoblast culture Stem cell reports High 28943254
2019 Sox7 enforced expression in adult bone marrow progenitors promotes proliferation of multi-lineage short-term engrafting blood progenitors and induces a profound block in B lymphocyte generation both ex vivo and in vivo, causing extra-medullary hematopoiesis in spleen and liver. Inducible transgenic mouse model, bone marrow/stroma co-culture, transplantation assay, FACS Open biology High 27411892
2019 Sox7 promotes endothelial cell activation via the Jagged1-Notch1 pathway upon HLA I antibody stimulation; Sox7 knockdown reduces adhesion molecules (VCAM-1, ICAM-1), inflammatory cytokines (IL-6, TNF-α), and Jagged1-Notch1 signaling; Jagged1 overexpression rescues the effect of Sox7 knockdown. shRNA knockdown, Notch pathway inhibition (DAPT), Jagged1 overexpression rescue, in vivo kidney transplantation model Experimental cell research Medium 30639059
2019 Sox7 regulates lineage decisions in cardiovascular progenitor cells by promoting endothelial cell fate at the expense of cardiac lineage; ChIP-Seq combined with ATAC-Seq identified Sox7 target genes; SOX7 directly protein-protein interacts with GATA4 and interferes with GATA4 transcriptional activity on cardiac genes; Sox7 modulates WNT and BMP signaling during cardiovascular differentiation. ChIP-Seq, ATAC-Seq, transcriptomics, Co-immunoprecipitation (SOX7-GATA4 interaction), doxycycline-inducible overexpression Stem cells and development High 31154937
2020 SOX7 is rapidly and transiently upregulated in human endothelial cells during hypoxia and is required for hypoxia-induced angiogenesis; SOX7 depletion impairs angiogenic response in cultured primary human umbilical vein endothelial cells. RNA-Seq temporal profiling, siRNA knockdown, tube formation and sprouting angiogenesis assays The Journal of biological chemistry Medium 32071080
2021 Sox7 deficiency in mouse atrioventricular canal reduces Bmp2 in myocardium and Wnt4 in endocardium; Sox7 directly binds to the Wnt4 and Bmp2 promoters; exogenous WNT4 or BMP2 partially rescues impaired endothelial-to-mesenchymal transition (EndMT) caused by Sox7 deficiency, with BMP2 acting downstream of WNT4. Conditional knockout mouse, transcriptome analysis, ChIP/direct promoter binding assays, protein rescue experiments, Noggin inhibition Cell death & disease High 33846290
2022 Loss-of-function SOX7 mutation (Gln104*) fails to transactivate target genes GATA4 and BMP2 and invalidates cooperative transactivation with NKX2.5, as demonstrated by dual-luciferase reporter analysis; this mutation co-segregates with congenital heart disease in a pedigree. Dual-luciferase reporter assay, whole-exome sequencing, Sanger sequencing American journal of translational research Medium 35422912
2023 SOX7 in blood vascular endothelial cells non-cell-autonomously patterns lymphatic vessels by directly repressing VEGFC transcription at distant regulatory regions; SOX7 also directly binds HEY1 (a canonical Notch pathway repressor), suggesting recruitment of HEY1 to VEGFC genomic regulatory regions as a mechanism of transcriptional repression. Conditional loss-of-function in mice, identification of distant regulatory regions, direct binding assay, Co-IP for SOX7-HEY1 interaction The EMBO journal High 36715213
2023 Endothelial-specific loss of Sox7 in mice leads to ventricular non-compaction-like defects and abnormal coronary artery formation; Sox7 loss disrupts transcriptional regulation of Notch pathway genes and connexins 37 and 40, which govern coronary arterial specification; a subset of Sox7-null endothelial cells transdifferentiate into hematopoietic lineages. Endothelial-specific conditional knockout, single-nuclei transcriptomics, fate mapping, immunofluorescence EMBO reports High 37551717
2012 SOX7 co-localizes with mutant β-catenin or TCF4 in the nucleus and physically interacts with both wild-type and mutant β-catenin as well as TCF4; SOX7 inhibits TCF/LEF-1-dependent transcription induced by Wnt-1 and suppresses Wnt targets Cyclin D1 and c-Myc in endometrial cancer cells. Co-immunoprecipitation, immunofluorescent microscopy, luciferase reporter assay, Western blot Oncotarget High 23295859
2024 SOX7 binds to the promoter of DNMT3B and transcriptionally represses it, leading to reduced methylation of the CYGB promoter and inhibition of bladder cancer progression; the SOX7/DNMT3B/CYGB axis was validated by ChIP and functional experiments. ChIP assay, Western blot, RNA-seq, immunohistochemistry, knockdown and overexpression experiments in BCa cell lines Molecular biomedicine Medium 39227479

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 Sox18 and Sox7 play redundant roles in vascular development. Blood 165 18094332
2016 The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Nature communications 152 27150562
2001 SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling. Nucleic acids research 146 11691915
2017 LncRNA MEG3 enhances cisplatin sensitivity in non-small cell lung cancer by regulating miR-21-5p/SOX7 axis. OncoTargets and therapy 106 29123412
2008 Zebrafish Sox7 and Sox18 function together to control arterial-venous identity. Developmental biology 105 18377889
2009 Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice. Development (Cambridge, England) 84 19515696
2015 Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina. PloS one 80 26630461
2008 Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells. Molecular cancer research : MCR 80 18819930
2005 SOX7 and SOX18 are essential for cardiogenesis in Xenopus. Developmental dynamics : an official publication of the American Association of Anatomists 73 16193513
2012 Mouse model reveals the role of SOX7 in the development of congenital diaphragmatic hernia associated with recurrent deletions of 8p23.1. Human molecular genetics 72 22723016
2004 Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression. Molecular and cellular biology 70 15542856
2012 SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development. Development (Cambridge, England) 69 22492353
2002 Expression of human SOX7 in normal tissues and tumors. International journal of molecular medicine 68 11891528
2018 miR-24-3p promotes cell migration and proliferation in lung cancer by targeting SOX7. Journal of cellular biochemistry 67 29231262
2008 SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells. Cancer letters 67 19108950
2004 SOX7 and SOX17 regulate the parietal endoderm-specific enhancer activity of mouse laminin alpha1 gene. The Journal of biological chemistry 67 15220343
2016 MicroRNA-452 promotes stem-like cells of hepatocellular carcinoma by inhibiting Sox7 involving Wnt/β-catenin signaling pathway. Oncotarget 65 27058905
2012 Down-regulation of Sox7 is associated with aberrant activation of Wnt/b-catenin signaling in endometrial cancer. Oncotarget 65 23295859
2013 SOX7 is down-regulated in lung cancer. Journal of experimental & clinical cancer research : CR 63 23557216
2009 Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification. Blood 61 19801444
2014 Mir-184 post-transcriptionally regulates SOX7 expression and promotes cell proliferation in human hepatocellular carcinoma. PloS one 60 24558429
2014 MiR-492 contributes to cell proliferation and cell cycle of human breast cancer cells by suppressing SOX7 expression. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 60 25407488
2017 MiR-9 is involved in TGF-β1-induced lung cancer cell invasion and adhesion by targeting SOX7. Journal of cellular and molecular medicine 57 28266181
2013 The regulation of SOX7 and its tumor suppressive role in breast cancer. The American journal of pathology 54 24012678
2013 SOX7: from a developmental regulator to an emerging tumor suppressor. Histology and histopathology 54 24288056
2004 SOX7 and GATA-4 are competitive activators of Fgf-3 transcription. The Journal of biological chemistry 50 15082719
2015 Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia. Blood 49 25940713
2016 miR-935 Promotes Liver Cancer Cell Proliferation and Migration by Targeting SOX7. Oncology research 48 27697092
2014 miR-24 promotes the proliferation and invasion of HCC cells by targeting SOX7. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 48 25073511
2015 Sox7 controls arterial specification in conjunction with hey2 and efnb2 function. Development (Cambridge, England) 44 25834021
2019 LncRNA FTX inhibits hippocampal neuron apoptosis by regulating miR-21-5p/SOX7 axis in a rat model of temporal lobe epilepsy. Biochemical and biophysical research communications 43 30871773
2019 SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells. Oncogene 42 31332289
2019 Long noncoding RNA XIST participates hypoxia-induced angiogenesis in human brain microvascular endothelial cells through regulating miR-485/SOX7 axis. American journal of translational research 42 31737200
2018 Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality. The Journal of experimental medicine 41 29444818
2014 Reduced expression of SOX7 in ovarian cancer: a novel tumor suppressor through the Wnt/β-catenin signaling pathway. Journal of ovarian research 40 25297608
2009 SOX15 and SOX7 differentially regulate the myogenic program in P19 cells. Stem cells (Dayton, Ohio) 40 19489079
2016 miR-935 promotes gastric cancer cell proliferation by targeting SOX7. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 36 27044823
2016 SOX7 is associated with the suppression of human glioma by HMG-box dependent regulation of Wnt/β-catenin signaling. Cancer letters 34 26944317
2016 MiR-595 targeting regulation of SOX7 expression promoted cell proliferation of human glioblastoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 33 27133048
2016 Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac. Development (Cambridge, England) 32 27802172
2018 MicroRNA-494-3p Promotes Cell Growth, Migration, and Invasion of Nasopharyngeal Carcinoma by Targeting Sox7. Technology in cancer research & treatment 31 30381030
2015 Overexpression of miR-664 is associated with enhanced osteosarcoma cell migration and invasion ability via targeting SOX7. Clinical and experimental medicine 31 26515813
2016 SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer. Scientific reports 29 27188720
2014 The suppressive role of SOX7 in hepatocarcinogenesis. PloS one 28 24816720
2018 Overexpression of microRNA-34a Attenuates Proliferation and Induces Apoptosis in Pituitary Adenoma Cells via SOX7. Molecular therapy oncolytics 27 30109259
2017 SOX7 expression is critically required in FLK1-expressing cells for vasculogenesis and angiogenesis during mouse embryonic development. Mechanisms of development 26 28577909
2014 Sox7 is regulated by ETV2 during cardiovascular development. Stem cells and development 26 24762086
2020 ACTA2-AS1 suppresses lung adenocarcinoma progression via sequestering miR-378a-3p and miR-4428 to elevate SOX7 expression. Cell biology international 25 32808728
2017 MicroRNA-616 promotes the growth and metastasis of non-small cell lung cancer by targeting SOX7. Oncology reports 25 28765960
2017 MiR-616 promotes proliferation and inhibits apoptosis in glioma cells by suppressing expression of SOX7 via the Wnt signaling pathway. European review for medical and pharmacological sciences 25 29271996
2014 Sox7 in vascular development: review, insights and potential mechanisms. The International journal of developmental biology 25 24860989
2008 Lineage specification of Flk-1+ progenitors is associated with divergent Sox7 expression in cardiopoiesis. Differentiation; research in biological diversity 24 19272523
2004 Embryonic expression of Xenopus laevis SOX7. Gene expression patterns : GEP 24 14678825
2018 SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function. International journal of molecular sciences 22 29757932
2020 Long noncoding RNA HAND2-AS1 restrains proliferation and metastasis of breast cancer cells through sponging miR-1275 and promoting SOX7. Cancer biomarkers : section A of Disease markers 20 31683462
2021 CircUBQLN1 Promotes Proliferation but Inhibits Apoptosis and Oxidative Stress of Hippocampal Neurons in Epilepsy via the miR-155-Mediated SOX7 Upregulation. Journal of molecular neuroscience : MN 19 33835399
2017 Genome-wide transcriptomics analysis identifies sox7 and sox18 as specifically regulated by gata4 in cardiomyogenesis. Developmental biology 19 29229250
2017 SOX7 Suppresses Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction. DNA and cell biology 19 29271667
2016 SOX7 inhibits tumor progression of glioblastoma and is regulated by miRNA-24. Open medicine (Warsaw, Poland) 19 28352781
2020 Long non-coding RNA NBAT1 inhibits the progression of glioma through the miR-21/SOX7 axis. Oncology letters 18 32782620
2020 Comprehensive transcriptomic profiling reveals SOX7 as an early regulator of angiogenesis in hypoxic human endothelial cells. The Journal of biological chemistry 17 32071080
2018 Classic SRY-box protein SOX7 functions as a tumor suppressor regulating WNT signaling and is methylated in renal cell carcinoma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17 29957056
2018 Knockdown of miR‑935 increases paclitaxel sensitivity via regulation of SOX7 in non‑small‑cell lung cancer. Molecular medicine reports 17 30066948
2011 SOX7 is involved in aspirin-mediated growth inhibition of human colorectal cancer cells. World journal of gastroenterology 17 22171135
2017 Long noncoding RNA AB073614 promotes the malignance of glioma by activating Wnt/β-catenin signaling through downregulating SOX7. Oncotarget 16 29029454
2019 Sox7 Regulates Lineage Decisions in Cardiovascular Progenitor Cells. Stem cells and development 15 31154937
2019 MiR-128/SOX7 alleviates myocardial ischemia injury by regulating IL-33/sST2 in acute myocardial infarction. Biological chemistry 14 30265647
2018 A novel role for sox7 in Xenopus early primordial germ cell development: mining the PGC transcriptome. Development (Cambridge, England) 14 29158442
2022 The mechanism by which crocetin regulates the lncRNA NEAT1/miR-125b-5p/SOX7 molecular axis to inhibit high glucose-induced diabetic retinopathy. Experimental eye research 13 35718188
2019 MiRNA-616 aggravates the progression of bladder cancer by regulating cell proliferation, migration and apoptosis through downregulating SOX7. European review for medical and pharmacological sciences 13 31773697
2018 miR-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7. Oncology letters 13 30008922
2015 SOX7 interferes with β-catenin activity to promote neuronal apoptosis. The European journal of neuroscience 13 25847511
2021 The transcription factor Sox7 modulates endocardiac cushion formation contributed to atrioventricular septal defect through Wnt4/Bmp2 signaling. Cell death & disease 12 33846290
2018 Sox7 negatively regulates prostate-specific membrane antigen (PSMA) expression through PSMA-enhancer. The Prostate 12 30488457
2013 A potential relationship among beta-defensins haplotype, SOX7 duplication and cardiac defects. PloS one 11 24009689
2023 The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner. The EMBO journal 10 36715213
2022 miR-146a Inhibited Pancreatic Cancer Cell Proliferation by Targeting SOX7. Journal of healthcare engineering 10 35222878
2021 SOX7 suppresses endothelial-to-mesenchymal transitions by enhancing VE-cadherin expression during outflow tract development. Clinical science (London, England : 1979) 10 33720353
2019 Dll4 Blockade Promotes Angiogenesis in Nonhealing Wounds of Sox7-Deficient Mice. Advances in wound care 10 33095124
2022 SOX7 loss-of-function variation as a cause of familial congenital heart disease. American journal of translational research 9 35422912
2020 SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1. Acta pharmaceutica (Zagreb, Croatia) 9 31955140
2019 Novel role of sex-determining region Y-box 7 (SOX7) in tumor biology and cardiovascular developmental biology. Seminars in cancer biology 9 31473269
2015 Sox7 is dispensable for primitive endoderm differentiation from mouse ES cells. BMC developmental biology 9 26475439
2022 LncRNA BACE1-AS promotes the progression of osteosarcoma through miR-762/SOX7 axis. Molecular biology reports 8 35332412
2017 Identification of Slug and SOX7 as transcriptional repressors binding to the hepatitis B virus core promoter. Journal of hepatology 8 28887167
2017 SOX7 Is Required for Muscle Satellite Cell Development and Maintenance. Stem cell reports 7 28943254
2023 Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction. EMBO reports 6 37551717
2018 miR-452 promotes cell metastasis and the epithelial to mesenchymal by targeting SOX7 in clear-cell renal-cell carcinoma. Journal of cellular biochemistry 6 30506716
2016 SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development. Open biology 6 27411892
2024 Alveolar type 2 cells marker gene SFTPC inhibits epithelial-to-mesenchymal transition by upregulating SOX7 and suppressing WNT/β-catenin pathway in non-small cell lung cancer. Frontiers in oncology 5 39346732
2016 SOX7 promotes the maintenance and proliferation of B cell precursor acute lymphoblastic cells. Oncotarget 5 29029405
2024 SOX7 inhibits the malignant progression of bladder cancer via the DNMT3B/CYGB axis. Molecular biomedicine 4 39227479
2023 Salvianolic acid A improves nerve regeneration and repairs nerve defects in rats with brain injury by downregulating miR-212-3p-mediated SOX7. The Kaohsiung journal of medical sciences 4 37987200
2022 SOX7 modulates the progression of hepatoblastoma through the regulation of Wnt/β-catenin signaling pathway. Journal of cancer research and therapeutics 4 35645102
2021 RETRACTED: MicroRNA-376b-5p targets SOX7 to alleviate ischemic brain injury in a mouse model through activating Wnt/β-catenin signaling pathway. Life sciences 4 33482187
2021 SOX7 blocks vasculogenic mimicry in oral squamous cell carcinoma. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 4 33733517
2024 VEGF-dependent testicular vascularisation involves MEK1/2 signalling and the essential angiogenesis factors, SOX7 and SOX17. BMC biology 3 39354506
2019 Sox7 is involved in antibody-dependent endothelial cell activation and renal allograft injury via the Jagged1-Notch1 pathway. Experimental cell research 3 30639059
2016 [Aberrant methylation of the promoter regions of the SOX7 and p15INK4b genes and Wnt signaling pathway antagonists in patients with acute myeloid leukemias]. Terapevticheskii arkhiv 3 27459612
2022 Gfi1aa/Lsd1 Facilitates Hemangioblast Differentiation Into Primitive Erythrocytes by Targeting etv2 and sox7 in Zebrafish. Frontiers in cell and developmental biology 2 35096818