Affinage

SOX1

Transcription factor SOX-1 · UniProt O00570

Length
391 aa
Mass
39.0 kDa
Annotated
2026-06-10
100 papers in source corpus 26 papers cited in narrative 26 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SOX1 is an HMG-box transcription factor that governs neural progenitor identity and acts as a lineage-restricted tumor suppressor (PMID:9512512, PMID:14517545). It binds DNA through its HMG box at the SRY consensus motif (PMID:8625802), but target-gene selectivity is conferred by its proximal C-terminal domain, which recruits a partner factor; chimeric SOX1/SOX9 swaps showed the C-terminus, not the HMG domain, determines specificity at the DC5 crystallin enhancer (PMID:9609835, PMID:9858536). Through this architecture SOX1 directly activates structural target genes during lens development—it binds a conserved promoter element shared by gamma-crystallin genes, and its loss in mice produces microphthalmia and cataract from failed fiber-cell elongation, in part by repressing Pax6 (PMID:9512512, PMID:17306631). In the CNS, SOX1 keeps neuroepithelial cells undifferentiated by counteracting proneural bHLH proteins and by restraining two signaling pathways: it directly binds the Hes1 promoter to suppress Notch output, and it physically binds beta-catenin to inhibit TCF/LEF-dependent Wnt transcription (PMID:14517545, PMID:15110721). Beyond progenitor maintenance, SOX1 is required cell-autonomously in postmitotic ventral striatum neurons for their migration and subtype identity (PMID:15882093), marks adult dentate-gyrus radial astrocytes that generate granule neurons (PMID:22992951), and specifies rostral hindbrain fate by directly binding and activating GBX2 (PMID:32905879). In cancers SOX1 re-expression suppresses tumor growth through the same effectors—direct repression of HES1 and MYC and beta-catenin binding that blocks Wnt signaling—while its promoter is silenced through EZH2-mediated H3K27me3 and its transcript is repressed post-transcriptionally by miR-155 and by WTAP-directed m6A modification (PMID:22767186, PMID:37190139, PMID:37369660, PMID:39197387, PMID:39681745). SOX1 also partners with NKX2-1 to maintain neural-lineage state in small-cell lung cancer (PMID:35848993).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1996 Medium

    Established that SOX1 is a sequence-specific DNA-binding protein recognizing the SRY consensus, defining it biochemically as an HMG-box transcription factor rather than just a sequence homolog.

    Evidence In vitro HMG-box DNA-binding assay comparing SOX1/2/3

    PMID:8625802

    Open questions at the time
    • No in vivo target genes identified
    • Affinity differences not linked to functional output
  2. 1998 High

    Showed SOX1 is sufficient to impart neural fate and directly drives a structural target gene program, linking the factor to both neural determination and lens differentiation.

    Evidence Inducible expression in P19 cells; gamma-crystallin promoter interaction and knockout mice with microphthalmia/cataract; DC5 enhancer reporter with domain deletion

    PMID:9512512 PMID:9550729 PMID:9609835

    Open questions at the time
    • Partner factor at crystallin promoters not yet identified
    • Mechanism of neural induction at target-gene level unresolved
  3. 1999 High

    Localized target-gene selectivity to the proximal C-terminal domain rather than the HMG box, establishing that SOX1 specificity arises from partner-factor recruitment.

    Evidence Chimeric SOX1/SOX9 proteins, SOX2-VP16 fusions, and DC5 enhancer reporters

    PMID:9858536

    Open questions at the time
    • Identity of the proximal C-terminal partner factor not defined
    • Structural basis of the interaction unknown
  4. 2003 High

    Defined the core neural-progenitor function: SOX1-3 maintain the undifferentiated state by antagonizing proneural bHLH proteins in a mutually repressive circuit.

    Evidence Chick in ovo electroporation gain- and loss-of-function with neural markers

    PMID:14517545

    Open questions at the time
    • Direct transcriptional targets mediating the antagonism not identified
    • SOX1-specific versus redundant roles not separated
  5. 2004 Medium

    Identified specific signaling effectors of SOX1's progenitor-maintaining activity—direct Hes1 repression (Notch) and beta-catenin binding (Wnt)—both requiring its C-terminus.

    Evidence Promoter-binding and reporter assays, Co-IP, and overexpression in neural progenitors

    PMID:15110721

    Open questions at the time
    • beta-catenin interaction shown by Co-IP without structural mapping
    • SOX1 specificity over SOX2/3 at Hes1 not mechanistically explained
  6. 2005 High

    Extended SOX1 function beyond progenitors, showing a cell-autonomous requirement in postmitotic neurons for migration and subtype identity.

    Evidence Sox1-null beta-gal reporter and precursor-directed conditional rescue with in vivo fate/migration analysis

    PMID:15882093

    Open questions at the time
    • Transcriptional targets controlling migration not identified
    • Link to cytoskeletal machinery unresolved
  7. 2009 Medium

    Placed SOX1 within domain-specific neural patterning circuits and connected it to self-renewal control via Hes1 and Prox1 pathways.

    Evidence Sox1-null mice and in vitro gain/loss-of-function with cell-fate and cell-cycle analysis; ES cell neural differentiation with OE/KD

    PMID:18832594 PMID:19723505 PMID:21280160

    Open questions at the time
    • Direct versus indirect regulation of Prox1 pathway not resolved
    • How SOX1 is positioned downstream of PAX6/NKX2.2/Notch mechanistically unclear
  8. 2012 Medium

    Defined SOX1 as a tumor suppressor acting through beta-catenin binding, transferring its developmental Wnt-restraining function to a cancer context.

    Evidence GST pull-down, Co-IP, confocal co-localization, and TCF reporter assays in hepatocellular and nasopharyngeal carcinoma; in vivo lineage tracing of adult neural stem cells

    PMID:22767186 PMID:22992951 PMID:25427424

    Open questions at the time
    • Mechanism of proteasome-independent beta-catenin reduction unexplained
    • Whether SOX1 sequesters or degrades beta-catenin not reconciled across contexts
  9. 2020 High

    Provided genome-wide direct-target evidence (GBX2) for SOX1 in regional neural specification and revealed metabolic and miRNA control of its activity.

    Evidence SOX1 KO hESCs with ChIP-seq and GBX2 rescue; RNA-seq/metabolomics for retinoid pathway; ChIP/reporter for MRTF-A/miR-155 axis

    PMID:32382038 PMID:32675943 PMID:32905879

    Open questions at the time
    • Full SOX1 cistrome beyond GBX2 not characterized
    • Whether retinoid pathway activation is a direct transcriptional effect unknown
  10. 2023 Medium

    Consolidated SOX1's tumor-suppressive transcriptional logic by demonstrating direct repression of HES1 and MYC with phenotypic rescue.

    Evidence ChIP-PCR, RNA-seq, luciferase reporters, and HES1/MYC rescue in lung and nasopharyngeal cancer models

    PMID:37190139 PMID:37369660

    Open questions at the time
    • Cofactor requirements for repression not defined
    • Whether MYC/HES1 repression is direct in normal neural cells untested
  11. 2024 Medium

    Mapped the upstream silencing of SOX1 in cancer to converging epigenetic (EZH2/H3K27me3) and epitranscriptomic (WTAP m6A/YTHDF2) mechanisms.

    Evidence Co-IP, ChIP, and ubiquitination assays for USP2-EZH2-SOX1; MeRIP, RNA pulldown, RIP, and stability assays for WTAP/m6A

    PMID:39197387 PMID:39681745

    Open questions at the time
    • Whether these silencing mechanisms operate in normal development unknown
    • Interplay between H3K27me3 and m6A control of SOX1 not addressed

Open questions

Synthesis pass · forward-looking unresolved questions
  • The identity of the proximal C-terminal partner factor that confers SOX1 target-gene selectivity, and a unified structural model of how SOX1 both activates (crystallins, GBX2) and represses (Hes1, MYC, beta-catenin output) targets, remain unresolved.
  • No structure of SOX1 with DNA or partner factor
  • Mechanistic switch between activator and repressor modes undefined
  • Genome-wide cistrome and direct partner proteome incomplete

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003677 DNA binding 6 GO:0140110 transcription regulator activity 6
Localization
GO:0005634 nucleus 2
Pathway
R-HSA-1266738 Developmental Biology 5 R-HSA-1643685 Disease 5 R-HSA-74160 Gene expression (Transcription) 5 R-HSA-162582 Signal Transduction 4
Partners
CTNNB1NKX2-1

Evidence

Reading pass · 26 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 SOX1 protein binds the same DNA sequence motif as SRY via its HMG box domain, but with different affinity compared to SOX2 and SOX3, as demonstrated by in vitro DNA-binding assays. In vitro DNA-binding assay (HMG box binding to DNA motif) Development Medium 8625802
1998 SOX1 misexpression in P19 cells substitutes for retinoic acid in imparting neural fate to competent ectodermal cells, establishing SOX1 as sufficient for neural determination in this in vitro neurogenesis model. Inducible expression system in P19 cells; neural marker immunostaining and BrdU labeling Development Medium 9550729
1998 SOX1, SOX2, and SOX3 together account for the deltaEF2 factors that activate the delta1-crystallin minimal enhancer DC5 in lens cells, and this activation depends on their C-terminal domains. Enhancer reporter assay; domain deletion analysis Development Medium 9609835
1998 Targeted deletion of Sox1 in mice causes microphthalmia and cataract with failure of lens fiber cell elongation; SOX1 directly interacts with a promoter element conserved in all gamma-crystallin genes to drive their expression. Gene targeting (knockout mice); promoter binding/interaction assay Genes & Development High 9512512
1999 The proximal portion of the SOX1 C-terminal domain specifically interacts with a partner factor to confer target-gene selectivity; the HMG domain alone is insufficient for specificity. Chimeric SOX1/SOX9 proteins showed that DC5 enhancer activation requires the SOX1 C-terminal domain regardless of HMG domain origin. Chimeric protein analysis; enhancer reporter assay; SOX2-VP16 fusion experiments Molecular and Cellular Biology High 9858536
2003 SOX1-3 transcription factors keep neural cells undifferentiated by counteracting the activity of proneural bHLH proteins; conversely, proneural proteins direct neuronal differentiation by suppressing Sox1-3 expression in CNS progenitors. Chick in ovo electroporation (gain- and loss-of-function); neural marker analysis Nature Neuroscience High 14517545
2004 SOX1 (but not SOX2 or SOX3) directly binds the Hes1 promoter and suppresses Hes1 transcription, thereby attenuating Notch signaling; SOX1 also physically binds beta-catenin and suppresses TCF/LEF signaling. Both interactions require the C-terminus of SOX1. Additionally, SOX1 promotes cell cycle exit and upregulates neurogenin 1 transcription. Promoter-binding assay; overexpression in cultured neural progenitor cells; reporter assay; co-immunoprecipitation Developmental Biology Medium 15110721
2005 SOX1 is required in postmitotic ventral striatum neurons (not only progenitors) for their migration to correct position and acquisition of subtype identity; Sox1-null mice lack ventral striatum neurons due to a migration failure rather than a differentiation defect in precursors. Sox1-null allele expressing beta-galactosidase; conditional Sox1 expression directed to precursors; cell fate and migration analysis in vivo PLoS Biology High 15882093
2007 SOX1 is identified as the antigen recognized by anti-glial nuclear antibody (AGNA)-positive sera; IgG eluted from SOX1 clones reproduced the characteristic cerebellar Bergmann glia nuclear immunoreactivity. Fetal brain cDNA library probing; immunoblot of phage plaques; IgG elution and tissue immunostaining Neurology High 18032743
2007 In Sox1-null lens fiber cells, Pax6 is inappropriately maintained and its target alpha5 integrin is misexpressed; Sox1 heterozygosity partially rescues Pax6(Sey) lens diameter, demonstrating a genetic interaction between Sox1 and Pax6 in which Sox1 normally represses Pax6 during fiber cell differentiation. Immunostaining of Sox1-null mouse lenses; genetic rescue (double mutant analysis) Gene Expression Patterns Medium 17306631
2009 During the neuron-to-glial fate switch in ventral spinal cord, SOX1 expression is regulated downstream of PAX6, NKX2.2, and Notch signaling in a domain-specific manner; SOX1 in turn regulates Hes1 expression, and loss of Sox1 leads to enhanced oligodendrocyte precursor production from pMN domain. In vivo loss-of-function (Sox1 null mice); in vitro gain-of-function; cell-fate marker analysis Biochemical and Biophysical Research Communications Medium 19723505
2009 In mouse embryonic stem cell differentiation, Sox1 maintains cells at the neuroepithelial stage and prevents expression of Pax6 and radial glial markers; continuous Sox1 expression blocks the Sox1→Pax6 transition, while Pax6 expression in neuroepithelial cells triggers their differentiation into radial glia and promotes cell migration. Overexpression and knockdown (shRNA) in ES cell neural differentiation assays; marker immunostaining Stem Cells Medium 18832594
2011 SOX1 suppresses neurogenic cell divisions in cortical neural progenitors by acting through a Prox1-mediated pathway; loss of Sox1 leads to progressive depletion of self-renewing cells, elongated cell cycle, and increased cell cycle exit, both in vivo and in vitro. Sox1-null mouse cortical neural progenitor cells; gain/loss-of-function; cell cycle analysis; Prox1 pathway epistasis Stem Cells Medium 21280160
2012 SOX1 functions as a tumor suppressor in hepatocellular carcinoma by physically interacting with beta-catenin (but not with the beta-catenin/TCF complex), inhibiting TCF-responsive transcriptional activity and downstream Wnt target gene expression; interaction demonstrated by GST pull-down, co-immunoprecipitation, and confocal co-localization. GST pull-down; co-immunoprecipitation; TCF-responsive luciferase reporter assay; Western blot; confocal microscopy Hepatology Medium 22767186
2012 SOX1 expression marks an activated radial astrocyte population in the dentate gyrus subgranular zone that gives rise to the majority of newly born granular neurons and a small number of hilar astrocytes, as established by lineage tracing. Sox1-tTA;tetO-Cre;Rosa26 reporter lineage tracing in mice Development High 22992951
2014 SOX1 physically interacts with beta-catenin (shown by Co-IP) and reduces its expression in a proteasome-independent manner in nasopharyngeal carcinoma cells, leading to inhibition of Wnt/beta-catenin signaling. Co-immunoprecipitation; Western blot; proteasome inhibitor treatment; TCF reporter assay Molecular Cancer Medium 25427424
2015 Restoration of SOX1 expression in non-small cell lung cancer cells inhibits cell migration by regulating actin cytoskeletal remodeling. SOX1 re-expression in NSCLC cells; migration assay; actin cytoskeleton visualization Tumour Biology Low 25613070
2020 SOX1 is required for specification of rostral hindbrain neural progenitor cells from human embryonic stem cells; SOX1 knockout leads to upregulation of midbrain genes and downregulation of rostral hindbrain genes. ChIP-seq shows SOX1 binds the distal region of GBX2 to activate its expression, and GBX2 overexpression rescues SOX1-KO phenotypes. SOX1 knockout (hESC); ChIP-seq; GBX2 overexpression rescue; gene expression profiling iScience High 32905879
2020 miR-155 suppresses SOX1 expression by targeting its 3'UTR, and MRTF-A promotes this suppression by binding the miR-155 promoter to promote histone acetylation and RNA polymerase II recruitment via the Wnt-beta-catenin pathway, thus forming an MRTF-A/miR-155/SOX1 axis that mediates gastric cancer migration. ChIP assay; luciferase reporter assay; 3'UTR targeting validation; transwell and scratch-healing migration assays Cancer Cell International Medium 32675943
2022 NKX2-1 and SOX1 collaborate as core transcriptional regulators in the SCLC-Aα subtype; co-immunoprecipitation followed by mass spectrometry identified SOX1 as a functional transcriptional partner of NKX2-1, and their co-activity maintains neural lineage state through super-enhancers at both loci. Co-immunoprecipitation followed by mass spectrometry; ChIP-seq; CRISPR-Cas9 deletion; xenograft American Journal of Respiratory and Critical Care Medicine Medium 35848993
2023 SOX1 directly binds the HES1 promoter (identified by ChIP-PCR) and suppresses HES1 transcription in lung cancer cells; HES1 overexpression partially reverses the tumor-suppressive effect of SOX1, establishing HES1 as a direct transcriptional target downstream of SOX1. ChIP-PCR; RNA-seq; HES1 rescue experiment; in vitro and xenograft assays Cancers Medium 37190139
2023 SOX1 directly binds the MYC gene promoter, leading to transcriptional suppression of MYC; decreased SOX1 leads to MYC re-expression and re-entry into proliferation, establishing a SOX1-MYC axis in NPC quiescence and chemoresistance. Promoter binding assay (ChIP); luciferase reporter; quiescence/proliferation model Cell Death Discovery Medium 37369660
2024 USP2 stabilizes EZH2 by direct binding and reducing its ubiquitination; EZH2 then enriches H3K27me3 at the SOX1 promoter to epigenetically silence SOX1 expression, establishing a USP2-EZH2-SOX1 regulatory axis in bladder cancer progression. Co-immunoprecipitation; chromatin immunoprecipitation (ChIP); ubiquitination assay; xenograft model Translational Oncology Medium 39197387
2024 WTAP mediates m6A modification of SOX1 mRNA, leading to YTHDF2-dependent mRNA degradation and post-transcriptional repression of SOX1 in colorectal cancer; this was confirmed by MeRIP assay, RNA pulldown, dual-luciferase reporter, and RIP assay. MeRIP assay; RNA pulldown; dual-luciferase reporter; RIP assay; mRNA stability assay Digestive Diseases and Sciences Medium 39681745
2020 SOX1 promotes differentiation of nasopharyngeal carcinoma cells by activating the retinoid metabolic pathway; RNA-seq and untargeted metabolomics showed increased retinoid content in SOX1-overexpressing cells, linked to decreased expression of UGT2B7, which partially rescues the SOX1-induced differentiation phenotype. RNA-seq; LC/MS untargeted metabolomics; UGT2B7 rescue experiment Cell Death & Disease Medium 32382038
2021 miR-155-5p directly targets the 3'UTR of SOX1 to suppress its expression, resulting in activation of RAF/MEK/ERK phosphorylation and promotion of cholangiocarcinoma proliferation; restoration of SOX1 in miR-155-5p-overexpressing cells decreases RAF/MEK/ERK phosphorylation. Dual-luciferase reporter assay (3'UTR targeting); Western blot for pathway phosphorylation; cell proliferation and xenograft assays Cancer Cell International Medium 34876142

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nature neuroscience 668 14517545
1999 Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages. Mechanisms of development 442 10446282
1996 A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development (Cambridge, England) 385 8625802
1998 A role for SOX1 in neural determination. Development (Cambridge, England) 374 9550729
1998 Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction. Development (Cambridge, England) 269 9609835
1998 Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Genes & development 235 9512512
2003 Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice. Proceedings of the National Academy of Sciences of the United States of America 210 12923295
2007 SOX1 antibodies are markers of paraneoplastic Lambert-Eaton myasthenic syndrome. Neurology 164 18032743
2004 Sox1 acts through multiple independent pathways to promote neurogenesis. Developmental biology 147 15110721
1999 Mechanism of regulatory target selection by the SOX high-mobility-group domain proteins as revealed by comparison of SOX1/2/3 and SOX9. Molecular and cellular biology 138 9858536
2007 Essential alterations of heparan sulfate during the differentiation of embryonic stem cells to Sox1-enhanced green fluorescent protein-expressing neural progenitor cells. Stem cells (Dayton, Ohio) 108 17464092
2010 Interaction of Sox1, Sox2, Sox3 and Oct4 during primary neurogenesis. Developmental biology 93 21147085
2009 A Sox1 to Pax6 switch drives neuroectoderm to radial glia progression during differentiation of mouse embryonic stem cells. Stem cells (Dayton, Ohio) 92 18832594
2012 SOX1 functions as a tumor suppressor by antagonizing the WNT/β-catenin signaling pathway in hepatocellular carcinoma. Hepatology (Baltimore, Md.) 89 22767186
2012 DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS chemical neuroscience 83 22860217
2012 Sox1 marks an activated neural stem/progenitor cell in the hippocampus. Development (Cambridge, England) 79 22992951
2005 Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1. PLoS biology 73 15882093
2005 Frequency of SOX Group B (SOX1, 2, 3) and ZIC2 antibodies in Turkish patients with small cell lung carcinoma and their correlation with clinical parameters. Cancer 64 15880380
2018 Methylation of the hsa-miR-124, SOX1, TERT, and LMX1A genes as biomarkers for precursor lesions in cervical cancer. Gynecologic oncology 54 29960712
2011 Sox1 maintains the undifferentiated state of cortical neural progenitor cells via the suppression of Prox1-mediated cell cycle exit and neurogenesis. Stem cells (Dayton, Ohio) 53 21280160
2014 High methylation rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 genes in cervical adenocarcinoma. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 52 24407576
2013 SOX1 suppresses cell growth and invasion in cervical cancer. Gynecologic oncology 52 23927962
2014 Generation of highly purified neural stem cells from human adipose-derived mesenchymal stem cells by Sox1 activation. Stem cells and development 48 24138016
2005 Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse. The European journal of neuroscience 48 16197496
2014 SOX1 down-regulates β-catenin and reverses malignant phenotype in nasopharyngeal carcinoma. Molecular cancer 47 25427424
2014 PAX1/SOX1 DNA methylation and cervical neoplasia detection: a Taiwanese Gynecologic Oncology Group (TGOG) study. Cancer medicine 46 24799352
2019 Aberrant DNA methylation of PAX1, SOX1 and ZNF582 genes as potential biomarkers for esophageal squamous cell carcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 38 31629253
2020 Anti-SOX1 Antibodies in Paraneoplastic Neurological Syndrome. Journal of clinical neurology (Seoul, Korea) 37 33029958
2016 SOX1 inhibits breast cancer cell growth and invasion through suppressing the Wnt/β-catenin signaling pathway. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 37 27206213
2011 SOX1 antibodies in sera from patients with paraneoplastic neurological syndromes. Acta neurologica Scandinavica 37 21751968
2007 Dual function of Sox1 in telencephalic progenitor cells. Developmental biology 37 17719572
2009 Dynamic distribution and stem cell characteristics of Sox1-expressing cells in the cerebellar cortex. Cell research 36 19823196
2016 PAX1 and SOX1 methylation as an initial screening method for cervical cancer: a meta-analysis of individual studies in Asians. Annals of translational medicine 35 27826568
2017 Oncogenic activity of SOX1 in glioblastoma. Scientific reports 34 28425506
2016 Prevalence of anti-SOX1 reactivity in various neurological disorders. Journal of the neurological sciences 34 27653921
2013 Frequent concomitant epigenetic silencing of SOX1 and secreted frizzled-related proteins (SFRPs) in human hepatocellular carcinoma. Journal of gastroenterology and hepatology 32 23215838
2006 Expression of Sox1 during Xenopus early embryogenesis. Biochemical and biophysical research communications 32 17056008
2017 Expression of a SOX1 overlapping transcript in neural differentiation and cancer models. Cellular and molecular life sciences : CMLS 31 28674729
2008 Expression of Sox1, Sox2 and Sox9 is maintained in adult human cerebellar cortex. Neuroscience letters 31 19061938
2019 Caveats and Pitfalls of SOX1 Autoantibody Testing With a Commercial Line Blot Assay in Paraneoplastic Neurological Investigations. Frontiers in immunology 29 31031763
2004 Electrical and neurotransmitter activity of mature neurons derived from mouse embryonic stem cells by Sox-1 lineage selection and directed differentiation. The European journal of neuroscience 28 15610154
2009 SOX-1 autoantibodies in patients with paraneoplastic neurological syndromes. Autoimmunity reviews 27 19393214
2013 Cisplatin-induced downregulation of SOX1 increases drug resistance by activating autophagy in non-small cell lung cancer cell. Biochemical and biophysical research communications 26 23994634
2022 Transcriptional Circuitry of NKX2-1 and SOX1 Defines an Unrecognized Lineage Subtype of Small-Cell Lung Cancer. American journal of respiratory and critical care medicine 24 35848993
2015 Epigenetic inactivation of SOX1 promotes cell migration in lung cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 24 25613070
2021 LncRNA SOX1-OT V1 acts as a decoy of HDAC10 to promote SOX1-dependent hESC neuronal differentiation. EMBO reports 20 34927789
2020 The MRTF-A/miR-155/SOX1 pathway mediates gastric cancer migration and invasion. Cancer cell international 20 32675943
2016 SOX1 is correlated to stemness state regulator SALL4 through progression and invasiveness of esophageal squamous cell carcinoma. Gene 20 27576349
2016 Tfap2 and Sox1/2/3 cooperatively specify ectodermal fates in ascidian embryos. Development (Cambridge, England) 20 27888190
2012 SOX1 antibodies in Lambert-Eaton myasthenic syndrome and screening for small cell lung carcinoma. Annals of the New York Academy of Sciences 19 23278580
2019 Tumor-suppressor gene SOX1 is a methylation-specific expression gene in cervical adenocarcinoma. Medicine 18 31567982
2009 SOX1 links the function of neural patterning and Notch signalling in the ventral spinal cord during the neuron-glial fate switch. Biochemical and biophysical research communications 15 19723505
2008 Survival, migration, and differentiation of Sox1-GFP embryonic stem cells in coculture with an auditory brainstem slice preparation. Cloning and stem cells 15 18241123
2007 Pax6 is misexpressed in Sox1 null lens fiber cells. Gene expression patterns : GEP 15 17306631
2024 PAX1/SOX1 DNA Methylation Versus Cytology and HPV16/18 Genotyping for the Triage of High-Risk HPV-Positive Women in Cervical Cancer Screening: Retrospective Analysis of Archival Samples. BJOG : an international journal of obstetrics and gynaecology 13 39327707
2015 Triage of Atypical Glandular Cell by SOX1 and POU4F3 Methylation: A Taiwanese Gynecologic Oncology Group (TGOG) Study. PloS one 13 26057869
2024 Analysis of the diagnostic performance of PAX1/SOX1 gene methylation in cervical precancerous lesions and its role in triage diagnosis. Journal of medical virology 12 38727013
2022 SOX1 antibody-related paraneoplastic neurological syndromes: clinical correlates and assessment of laboratory diagnostic techniques. Journal of neurology 12 36512064
2021 MiR-155-5p suppresses SOX1 to promote proliferation of cholangiocarcinoma via RAF/MEK/ERK pathway. Cancer cell international 12 34876142
2020 Coexistence of Anti-SOX1 and Anti-GABAB Receptor Antibodies with Autoimmune Encephalitis in Small Cell Lung Cancer: A Case Report. Clinical interventions in aging 12 32103919
2020 SOX1 promotes differentiation of nasopharyngeal carcinoma cells by activating retinoid metabolic pathway. Cell death & disease 12 32382038
2013 Dual origin of melanocytes defined by Sox1 expression and their region-specific distribution in mammalian skin. Development, growth & differentiation 12 23347447
2023 SOX1 Functions as a Tumor Suppressor by Repressing HES1 in Lung Cancer. Cancers 11 37190139
2019 Anti-SOX1 antibody-positive paraneoplastic neurological syndrome presenting with Lambert-Eaton myasthenic syndrome and small cell lung cancer: A case report. Thoracic cancer 10 31880403
2022 Coexistence of anti-SOX1 and anti-GABAB receptor antibodies with paraneoplastic limbic encephalitis presenting with seizures and memory impairment in small cell lung cancer: A case report. Frontiers in immunology 9 35967304
2021 Establishment of a developmental neurotoxicity test by Sox1-GFP mouse embryonic stem cells. Reproductive toxicology (Elmsford, N.Y.) 9 34273508
2016 Efficient derivation of dopaminergic neurons from SOX1⁻ floor plate cells under defined culture conditions. Journal of biomedical science 9 26956435
2016 Development of a multiplex MethyLight assay for the detection of DAPK1 and SOX1 methylation in epithelial ovarian cancer in a north Indian population. Genes & genetic systems 9 27452040
2023 Algorithm to improve the diagnosis of paraneoplastic neurological syndromes associated with SOX1 antibodies. Frontiers in immunology 8 37207233
2023 SOX1 acts as a tumor hypnotist rendering nasopharyngeal carcinoma cells refractory to chemotherapy. Cell death discovery 8 37369660
2021 SOX1 Is a Backup Gene for Brain Neurons and Glioma Stem Cell Protection and Proliferation. Molecular neurobiology 8 33481176
2020 SOX1 Promoter Hypermethylation as a Potential Biomarker for High-Grade Squamous Intraepithelial Neoplasia Lesion and Cervical Carcinoma: A Meta-Analysis With Trial Sequential Analysis. Frontiers in genetics 8 32849763
2020 SOX1 Is Required for the Specification of Rostral Hindbrain Neural Progenitor Cells from Human Embryonic Stem Cells. iScience 8 32905879
2024 The role of deubiquitinase USP2 in driving bladder cancer progression by stabilizing EZH2 to epigenetically silence SOX1 expression. Translational oncology 7 39197387
2020 Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome with SOX-1 Antibodies. Internal medicine (Tokyo, Japan) 7 33328403
2018 Cerebellar Ataxia With Extreme Photophobia Associated With Anti-SOX1 Antibodies. The Neurohospitalist 7 31244974
2024 WTAP Regulates SOX1 Expression to Affect the Tumorigenicity of Colorectal Cancer via an m6A-YTHDF2-Dependent Manner. Digestive diseases and sciences 6 39681745
2020 Association of MAPK4 and SOX1-OT gene polymorphisms with cleft lip palate in multiplex families: A genetic study. Journal of dental research, dental clinics, dental prospects 6 32908649
2018 Generalized epilepsy and mild intellectual disability associated with 13q34 deletion: A potential role for SOX1 and ARHGEF7. Seizure 6 29734022
2016 Commentary: Participation of Sox-1 Expression and Signaling of β-Catenin in the Pathophysiology of Generalized Seizures in Cerebellum of Rat. CNS & neurological disorders drug targets 6 26295820
2016 Decreased Expression of Sox-1 in Cerebellum of Rat with Generalized Seizures Induced by Kindling Model. CNS & neurological disorders drug targets 6 26996170
2014 Sorting of Sox1-GFP Mouse Embryonic Stem Cells Enhances Neuronal Identity Acquisition upon Factor-Free Monolayer Differentiation. BioResearch open access 6 24940564
2024 PAX1 and SOX1 Gene Methylation as a Detection and Triage Method for Cervical Intraepithelial Neoplasia Diagnosis. Acta cytologica 5 38527422
2016 IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro. In vitro cellular & developmental biology. Animal 5 26956358
2006 Isolation and sequence analysis of the Sox-1, -2, -3 homologs in Trionyx sinensis and Alligator sinensis having temperature-dependent sex determination. Biochemical genetics 5 16691434
2022 CircFBXW7 inhibits the tumorigenesis of T-cell acute lymphoblastic leukemia through modulating miR-494-3p/SOX1 axis. Cell death discovery 4 35538053
2020 In Silico Identification of SOX1 Post-Translational Modifications Highlights a Shared Protein Motif. Cells 4 33202879
2025 Analysis the diagnostic performance of H4C6/SOX1-OT gene methylation in bladder cancer based on urine sample. Scientific reports 3 40011626
2023 Anti-SOX1 antibodies-positive paraneoplastic neurological syndromes caused by thyroid carcinoma: A case report. Medicine 3 37083806
2022 Expanding the spectrum of SOX1-antibodies in neuropathy: the coexistence of anti-SOX1 and Guillain-Barré syndrome-a case report. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 3 35391602
2022 SOX-1 antibodies in a patient with Crohn's disease: a case report. BMC neurology 3 36324062
2021 A case of IVIg responsive paraneoplastic SOX1 peripheral neuropathy in a male with breast carcinoma. Journal of neuroimmunology 3 33508769
2021 Simultaneous paraneoplastic cerebellar degeneration, Lambert-Eaton syndrome and neuropathy associated with AGNA/anti-SOX1 and VGCC antibodies. Neurological research and practice 3 34030742
2019 A rare case of long-term paraesthesia diagnosed as a paraneoplastic syndrome by anti-SOX1 antibody determination. BMJ case reports 3 31315840
2025 Meta-analysis of the diagnostic value of SOX1 methylation in different types of cervical cancer. World journal of surgical oncology 2 40259371
2025 Hypermethylation of SOX1 and HOXA9 Genes Is Associated with Clinicopathologic Characteristics of Non-Small Cell Lung Cancer Patients. Current issues in molecular biology 2 40699796
2024 SOX-1 antibodies positive Lambert-Eaton myasthenic syndrome with occult small cell lung cancer: A case report. The clinical respiratory journal 2 38497229
2024 Methylation of SOX1 and PAX1 Are Risk Factors and Potential Biomarkers for Cervical Lesions. World journal of oncology 2 39850527
2022 Anti-SOX1 Antibody-positive Small-cell Lung Cancer That Triggered Opsoclonus. Internal medicine (Tokyo, Japan) 2 35989271
2020 [A case of anti-SRY-Related HMG-Box Gene 1 (SOX1) antibody-positive chorea]. Rinsho shinkeigaku = Clinical neurology 2 33229831

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