Affinage

SNPH

Syntaphilin · UniProt O15079

Length
494 aa
Mass
53.5 kDa
Annotated
2026-06-10
52 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SNPH (syntaphilin) is a mitochondrial docking receptor that immobilizes mitochondria by tethering them to microtubules, controlling the balance between stationary and motile mitochondrial pools in neurons and other cell types (PMID:18191227). In axons, SNPH directly engages microtubules; its loss markedly increases the mobile mitochondrial fraction and reduces axonal mitochondrial density, with corresponding effects on synaptic facilitation (PMID:18191227). The docking interaction is stabilized by the dynein light chain LC8, which binds a defined seven-residue motif on SNPH and rigidifies an alpha-helical coiled-coil within the microtubule-binding domain (PMID:19641106), and by non-degradative ubiquitination on Lys111/Lys153 within that same domain by the E3 ligase CHIP/STUB1, which locks SNPH onto tubulin to restrain motility and dynamics (PMID:29898993). Anchoring is reversible and stress-responsive: stressed axonal mitochondria undergo bulk release of SNPH onto retrograde late-endosomal cargos for clearance toward the soma, independent of Parkin, Drp1, and autophagy (PMID:28472658). The physiological consequences of anchoring are strongly context-dependent — SNPH-mediated immobilization causes local ATP depletion that impairs axon regeneration after injury (PMID:27268498), and is harmful in dysmyelinating disease (PMID:25834054), yet does not drive rapid-onset SOD1 ALS pathology (PMID:21518771). SNPH is normally axon-restricted; pathological intrusion into dendrites driven by IL-1β/NMDAR crosstalk (PMID:35970564) and upstream tau hyperphosphorylation [PMID:bio_10.1101_2025.09.05.674541] produces excitotoxic mitochondrial immobilization and neuronal death (PMID:31618636). Beyond neurons, SNPH anchors mitochondria away from the cortical cytoskeleton in tumor cells and neutrophils, limiting motility-driving bioenergetics and thereby suppressing metastasis (PMID:27991488, PMID:28891816, PMID:36548516); a tumor-mitochondrial SNPH isoform additionally buffers oxidative stress and sustains complex II-dependent metabolism (PMID:28891816), and SNPH is transcriptionally downregulated through hypoxia/HIF-1α-driven microRNA axes to promote an invasive phenotype (PMID:41888092).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2008 High

    Established the founding function of SNPH: whether a dedicated receptor immobilizes axonal mitochondria was unknown, and this work showed SNPH docks mitochondria to microtubules to set the stationary/motile balance.

    Evidence snph knockout mice, time-lapse live imaging, genetic rescue and overexpression in neurons

    PMID:18191227

    Open questions at the time
    • Direct structural basis of the SNPH–microtubule contact not resolved
    • Signals that engage or release docking not yet defined
  2. 2009 High

    Addressed how the docking interaction is stabilized, showing LC8 binds a discrete seven-residue motif and rigidifies the microtubule-binding coiled-coil to strengthen anchoring.

    Evidence Biochemical pulldown, mutagenesis mapping, circular dichroism, time-lapse imaging in snph WT and KO neurons

    PMID:19641106

    Open questions at the time
    • How LC8 binding is regulated dynamically unknown
    • Stoichiometry of the SNPH–LC8–microtubule assembly not determined
  3. 2011 High

    Tested whether SNPH-dependent transport defects drive ALS pathology; double-mutant epistasis showed restoring mitochondrial mobility does not alter SOD1(G93A) disease course.

    Evidence Genetic cross of SOD1(G93A) and snph(-/-) mice with behavioral and neuropathological readouts

    PMID:21518771

    Open questions at the time
    • Does not address SNPH roles in slower-onset neurodegeneration
    • Does not exclude transport involvement in other ALS models
  4. 2015 High

    Showed mitochondrial anchoring can be actively harmful in a disease-specific manner: SNPH deletion benefits dysmyelinating Shiverer mice but not inflammatory EAE.

    Evidence SNPH KO in Shiverer and EAE models, survival, neuropathology and oxidative stress assays

    PMID:25834054

    Open questions at the time
    • Mechanism distinguishing degenerative vs inflammatory contexts unresolved
    • Cell type responsible for the benefit not pinpointed
  5. 2016 High

    Connected anchoring to axonal energy supply and regeneration, showing rising SNPH in mature neurons immobilizes mitochondria, causing ATP deficits that limit axon repair.

    Evidence snph KO mice, in vivo sciatic nerve crush, live imaging, ATP measurements

    PMID:27268498

    Open questions at the time
    • Trigger for the developmental rise in SNPH unknown
    • Translation to CNS regeneration not established
  6. 2016 High

    Extended SNPH function beyond neurons, identifying it in a screen as a suppressor of tumor cell mitochondrial trafficking, motility and metastasis.

    Evidence Genome-wide shRNA screen, mitochondrial imaging, chemotaxis and in vivo metastasis models

    PMID:27991488

    Open questions at the time
    • Direct interplay with KIF5B/Miro1/2 not biochemically mapped
    • Whether the neuronal MT-docking mechanism applies identically in tumor cells unclear
  7. 2017 High

    Defined the regulated release arm of the mechanism: stressed mitochondria shed SNPH onto retrograde late-endosomal cargos for clearance independent of canonical mitophagy.

    Evidence Immuno-EM, super-resolution and live imaging, Parkin/Drp1/autophagy epistasis, snph KO neurons

    PMID:28472658

    Open questions at the time
    • Molecular trigger of bulk SNPH release not identified
    • Fate of released SNPH cargo in the soma unresolved
  8. 2017 High

    Revealed a tumor-mitochondrial SNPH isoform with a metabolic role, buffering oxidative stress and sustaining complex II bioenergetics while hypoxia lowers SNPH to favor invasion.

    Evidence Isoform characterization, KD/KO, xenograft and syngeneic tumor models, metabolic assays

    PMID:28891816

    Open questions at the time
    • Mechanism of redox buffering not defined
    • How splice isoform targeting is controlled unknown
  9. 2018 High

    Identified post-translational control of docking, showing CHIP/STUB1 ubiquitinates SNPH on Lys111/Lys153 non-degradatively to lock it onto tubulin and restrain motility.

    Evidence Proteomics, site-directed mutagenesis (K111R/K153R), in vitro ubiquitination, motility imaging, in vivo metastasis

    PMID:29898993

    Open questions at the time
    • Deubiquitinase reversing the modification unknown
    • Signals controlling CHIP activity on SNPH not defined
  10. 2019 High

    Established that compartmental restriction matters: SNPH is normally axon-excluded, and forced dendritic intrusion sensitizes neurons to NMDAR-driven excitotoxicity and blocks somal mitophagy.

    Evidence Viral transduction in SNPH-KO mice, electrophysiology, calcium and live-cell imaging, Purkinje viability assays

    PMID:31618636

    Open questions at the time
    • Machinery enforcing normal axonal targeting not identified
    • How intrusion impairs calcium uptake mechanistically unclear
  11. 2022 Medium

    Placed SNPH downstream of inflammatory/excitatory signaling, showing IL-1β and NMDAR act synergistically to drive dendritic SNPH intrusion as the effector of excitotoxicity.

    Evidence SNPH-/- and WT hippocampal cultures, MK-801 and tyrosine inhibitors, immunofluorescence, viability assays

    PMID:35970564

    Open questions at the time
    • Molecular link transducing IL-1β/NMDAR signals to SNPH relocation unknown
    • In vivo relevance not demonstrated in this study
  12. 2023 Medium

    Extended the trafficking-suppressor role to immune cells, showing SNPH restrains neutrophil/PMN-MDSC mitochondrial motility, metabolism and migration to limit metastasis.

    Evidence SNPH-KO mice, mitochondrial imaging in PMN, metabolic flux and migration assays, in vivo metastasis

    PMID:36548516

    Open questions at the time
    • Whether the same MT-docking biochemistry operates in PMN not shown
    • Link between adenosine generation and migration not fully dissected
  13. 2023 Medium

    Identified a glial role, showing SNPH localizes to oligodendrocytes and myelin and is redistributed by netrin-1 to retain mitochondria at adhesion sites.

    Evidence Immunofluorescence, live imaging, netrin-1 bead adhesion assay, in vivo myelin fractionation

    PMID:37272718

    Open questions at the time
    • Functional consequence of glial mitochondrial retention for myelination not established
    • Receptor coupling netrin-1 to SNPH redistribution unknown
  14. 2024 Medium

    Demonstrated transcriptional/microRNA control of SNPH relevant to repair, showing miR-146b suppresses the snphb ortholog to enhance axonal mitochondrial transport and regeneration.

    Evidence CRISPR/Cas9, single-cell electroporation, in vivo imaging and escape-response assay in zebrafish

    PMID:39645618

    Open questions at the time
    • Conservation of the miR-146b axis in mammals not shown
    • Direct miR-146b–snphb interaction context dependence unclear
  15. 2026 Medium

    Defined a hypoxia-driven regulatory axis in cancer, showing HIF-1α/miR-130a-3p suppresses SNPH to raise ROS and activate an AKT/cdc42/PAK1/Cofilin filopodia program promoting invasion.

    Evidence Luciferase reporter, ROS and pathway assays, filopodia imaging, in vivo xenograft metastasis

    PMID:41888092

    Open questions at the time
    • Direct connection between SNPH loss and ROS production mechanistically incomplete
    • Relative contribution of trafficking vs metabolic effects not separated
  16. 2026 Medium

    Identified upstream kinase signaling controlling SNPH-dependent mitochondrial recruitment, with PAK5 interacting with SNPH downstream of Akt to drive mitochondrial recruitment to injured axons after stroke.

    Evidence Co-IP, molecular docking, surface plasmon resonance, RNA-seq, MCAO mouse model with Akt inhibition

    PMID:42134501

    Open questions at the time
    • PAK5–SNPH interaction shown by Co-IP/docking without mapped phosphosite
    • Whether PAK5 modifies SNPH directly unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How SNPH is dynamically switched between anchored and released states and how its strict axonal targeting is enforced and broken under disease remain unresolved at the molecular level.
  • No defined trigger linking signaling inputs (tau, IL-1β/NMDAR, PAK5) to SNPH relocation or release
  • No structural model of the SNPH–microtubule–LC8 complex
  • Deubiquitinase counterpart to CHIP not identified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 3 GO:0140313 molecular sequestering activity 3
Localization
GO:0005739 mitochondrion 3 GO:0005856 cytoskeleton 3 GO:0005768 endosome 1
Pathway
R-HSA-1643685 Disease 3 R-HSA-9609507 Protein localization 3 R-HSA-1430728 Metabolism 2
Partners
DYNLL1FUSKIF5BPAK5RHOT1RHOT2STUB1

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 SNPH acts as an axonal mitochondrial docking receptor by interacting with microtubules. Axonal mitochondria containing exogenous or endogenous SNPH lose mobility; deletion of the snph gene in mice results in a substantially higher proportion of mobile axonal mitochondria and reduced axonal mitochondrial density, with enhanced short-term synaptic facilitation rescued by reintroduction of snph. snph knockout mouse, time-lapse live imaging, genetic rescue, overexpression in neurons Cell High 18191227
2009 Dynein light chain LC8 binds to a specific seven-residue motif on SNPH, enhancing the SNPH–microtubule docking interaction. LC8 recruits to axonal mitochondria via SNPH; deletion of the LC8-binding motif impairs SNPH-mediated mitochondrial immobilization. LC8 stabilizes an alpha-helical coiled-coil within the SNPH microtubule-binding domain against thermal unfolding. LC8 reduces mitochondrial mobility in snph(+/+) but not snph(-/-) neurons, confirming dependence on SNPH. Proteomic/biochemical pulldown, mutagenesis, time-lapse live imaging in snph WT and KO neurons, circular dichroism spectroscopy The Journal of neuroscience High 19641106
2011 Genetic deletion of snph in SOD1(G93A) ALS mice doubles the proportion of mobile axonal mitochondria but does not alter disease onset, motor function decline, motor neuron loss, gliosis, or lifespan, indicating that reduced mitochondrial transport seen in SOD1(G93A) mice is not a primary driver of rapid-onset fALS pathology. Genetic cross of SOD1(G93A) and snph(-/-) mice, time-lapse imaging, behavioral assays, neuropathology The Journal of biological chemistry High 21518771
2015 Deletion of SNPH in Shiverer dysmyelinating mice prolongs survival, reduces cerebellar damage, suppresses oxidative stress, and improves mitochondrial health, demonstrating a context-dependent harmful role of mitochondrial anchoring in demyelination. In contrast, SNPH deletion does not benefit EAE (inflammatory MS model), indicating specificity to the progressive/degenerative phase. Genetic deletion (SNPH KO) in Shiverer mice and EAE model, survival analysis, neuropathology, oxidative stress assays The Journal of neuroscience High 25834054
2016 SNPH levels increase in mature neurons, causing mitochondrial anchoring that produces local ATP depletion and energy deficits in injured axons after axotomy. Genetic deletion of snph enhances mitochondrial transport, replenishes healthy mitochondria in injured axons, rescues energy deficits, and accelerates axon regeneration in vivo after sciatic nerve crush. snph KO mice, in vivo sciatic nerve crush, live imaging, ATP measurements, genetic manipulation The Journal of cell biology High 27268498
2016 In tumor cells, SNPH (via a network including KIF5B and Miro1/2) anchors mitochondria to the cortical cytoskeleton and thereby suppresses mitochondrial trafficking, cell motility, chemotaxis, and metastasis in vivo. SNPH shRNA knockdown increases mitochondrial speed and distance travelled, repositions mitochondria to the cortical cytoskeleton, and promotes metastasis. Genome-wide shRNA screen, time-lapse mitochondrial imaging, chemotaxis assays, in vivo metastasis models Nature communications High 27991488
2017 Stressed mitochondria are removed from axons through bulk release of SNPH from stressed mitochondria onto a new class of mitochondria-derived cargos that share retrograde transport on late endosomes toward the soma, independently of Parkin, Drp1, and autophagy. This SNPH-release mechanism is activated during early disease stages in ALS- and AD-linked neurons. Immuno-electron microscopy, super-resolution imaging, live imaging, genetic manipulation (Parkin/Drp1/autophagy KO/KD), snph KO neurons Neuron High 28472658
2017 Mitochondrial SNPH (alternatively spliced isoform targeted to tumor cell mitochondria) buffers oxidative stress and maintains complex II-dependent bioenergetics, sustaining local tumor cell proliferation while restricting mitochondrial redistribution to the cortical cytoskeleton and limiting tumor cell motility. Hypoxia acutely lowers SNPH levels, shifting cells from proliferative to invasive phenotype. Isoform characterization, SNPH KD/KO, xenograft and syngeneic tumor models in vivo, metabolic assays, live mitochondrial imaging The Journal of clinical investigation High 28891816
2018 SNPH is ubiquitinated by the E3 ligase CHIP (STUB1) on Lys111 and Lys153 within its microtubule-binding domain. This ubiquitination does not cause protein degradation but anchors SNPH on tubulin to inhibit mitochondrial motility and dynamics. Ubiquitination-defective SNPH mutants (K111R or K153R) increase mitochondrial speed and distance, reposition mitochondria to the cortical cytoskeleton, increase Drp1 recruitment, and enhance tumor chemotaxis, invasion, and metastasis in vivo. Global proteomics screen, site-directed mutagenesis (K111R, K153R), in vitro ubiquitination assay, mitochondrial motility imaging, in vivo metastasis models Cancer research High 29898993
2019 SNPH is normally excluded from dendrites and targeted to axons. In Shiverer mice (progressive MS model), SNPH is misplaced into dendrites of Purkinje cells. Reconstituting dendritic SNPH intrusion in SNPH-KO mice by viral transduction sensitizes Purkinje cells to excitotoxicity upon climbing fiber stimulation. In vitro, overexpression of SNPH in dendrites causes excitotoxicity via NMDA receptor activation, reduces mitochondrial calcium uptake, and blocks somal mitophagy. In vivo viral transduction, SNPH-KO mice, live-cell imaging, electrophysiology, calcium imaging, Purkinje cell viability assays Cell reports High 31618636
2021 FUS co-localizes with the mitochondrial tethering protein SNPH in neurons. Mutations in FUS alter this co-localization and are associated with changes in mitochondrial numbers and transport in primary neurons and zebrafish models. Co-localization (immunofluorescence), primary neuron and zebrafish overexpression models, mitochondrial transport assays Scientific reports Low 34193962
2022 IL-1β and NMDA each individually trigger dendritic SNPH intrusion in hippocampal neurons. They interact synergistically: blocking NMDAR with MK-801 prevents IL-1β from triggering dendritic SNPH intrusion, and decoupling IL-1β/NMDAR interaction with tyrosine inhibitors prevents either stimulus from causing intrusion. Neuronal toxicity caused by IL-1β or NMDA is strongly ameliorated in SNPH-/- neurons, placing SNPH downstream of IL-1β/NMDAR crosstalk as the effector of excitotoxicity. Primary hippocampal cultures from SNPH-/- and WT mice, pharmacological antagonists (MK-801, tyrosine inhibitors), immunofluorescence, cell viability assays The Journal of neuroscience Medium 35970564
2023 SNPH is expressed in oligodendrocyte precursor cells and mature oligodendrocytes and is present in the myelin sheath in vivo. Netrin-1 increases redistribution of SNPH to oligodendrocyte processes during myelin basic protein-positive membrane expansion, and SNPH clusters at the oligodendrocyte plasma membrane at sites of adhesion with netrin-1-coated beads where mitochondria are retained. Immunofluorescence, live imaging, netrin-1-coated microbead adhesion assay, in vitro oligodendrocyte cultures, in vivo myelin fractionation Glia Medium 37272718
2023 SNPH knockdown in tumor-bearing mice increases the speed and distance travelled by mitochondria in PMN (neutrophils/PMN-MDSCs), elevates rates of oxidative phosphorylation and glycolysis, and increases adenosine generation, resulting in enhanced spontaneous PMN migration and increased metastasis in SNPH-KO mice. SNPH-KO mice, mitochondrial motility imaging in PMN, metabolic flux assays, spontaneous migration assays, in vivo metastasis measurement Cancer immunology research Medium 36548516
2024 In zebrafish, miR-146b directly suppresses expression of snphb (SNPH ortholog). CRISPR/Cas9 manipulation and single-cell electroporation of the miR-146b-snphb axis enhances axonal mitochondrial trafficking and promotes Mauthner cell axon regeneration and functional recovery after injury. CRISPR/Cas9, single-cell electroporation, in vivo live imaging of mitochondrial transport, escape response behavioral assay in zebrafish Neuroscience bulletin Medium 39645618
2026 HIF-1α transcriptionally activates miR-130a-3p, which targets SNPH mRNA to suppress SNPH protein. SNPH downregulation promotes ROS production, activating the AKT/cdc42/PAK1/Cofilin cascade, leading to filopodia formation and increased CRC cell migration and invasion. SNPH overexpression increases mitochondrial fusion and suppresses liver metastasis in vivo. Luciferase reporter assay (HIF-1α→miR-130a-3p→SNPH), ROS measurement, AKT/cdc42/PAK1/Cofilin pathway assays, filopodia imaging, in vivo xenograft metastasis model Cell death & disease Medium 41888092
2026 BHD treatment activates the Akt/PAK5/SNPH signaling cascade, augmenting mitochondrial recruitment to injured axons after ischemic stroke. Co-immunoprecipitation and molecular docking indicate PAK5 interacts with SNPH. Inhibition of Akt abrogates both neuroprotection and SNPH-mediated mitochondrial recruitment. Co-immunoprecipitation, molecular docking, surface plasmon resonance, RNA-seq, Western blot, MCAO mouse model with Akt inhibition Journal of ethnopharmacology Medium 42134501
2025 In primary neuronal cultures, p-Tau kinase inhibitors and Tau-KO both completely abolish dendritic SNPH intrusion (DSI), placing tau hyperphosphorylation upstream of SNPH mislocalization into dendrites in a progressive MS model, and establishing DSI as a downstream effector of tauopathy-driven excitotoxicity. Primary neuronal cultures, pharmacological p-Tau kinase inhibitors, Tau-KO, immunofluorescence for dendritic SNPH localization bioRxivpreprint Medium bio_10.1101_2025.09.05.674541

Source papers

Stage 0 corpus · 52 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation. Cell 488 18191227
2016 Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits. The Journal of cell biology 270 27268498
2017 Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions. Neuron 160 28472658
2016 A neuronal network of mitochondrial dynamics regulates metastasis. Nature communications 113 27991488
2021 Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder. Molecular psychiatry 90 34471251
2009 Dynein light chain LC8 regulates syntaphilin-mediated mitochondrial docking in axons. The Journal of neuroscience : the official journal of the Society for Neuroscience 65 19641106
2011 Increased axonal mitochondrial mobility does not slow amyotrophic lateral sclerosis (ALS)-like disease in mutant SOD1 mice. The Journal of biological chemistry 51 21518771
2018 Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements. Cancer research 48 29898993
2014 Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens. G3 (Bethesda, Md.) 44 24928582
2017 Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. The Journal of clinical investigation 42 28891816
2008 Study of the cytotoxic activity of di and triphenyltin(IV) carboxylate complexes. Journal of inorganic biochemistry 42 18760840
2008 Cerebrospinal fluid markers before and after shunting in patients with secondary and idiopathic normal pressure hydrocephalus. Cerebrospinal fluid research 39 18439296
2015 Deletion of mitochondrial anchoring protects dysmyelinating shiverer: implications for progressive MS. The Journal of neuroscience : the official journal of the Society for Neuroscience 32 25834054
2010 Synthesis and biological applications of ionic triphenyltin(IV) chloride carboxylate complexes with exceptionally high cytotoxicity. Metallomics : integrated biometal science 32 21072389
2017 Removing dysfunctional mitochondria from axons independent of mitophagy under pathophysiological conditions. Autophagy 28 28812939
2021 Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations. Scientific reports 24 34193962
2024 The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's disease. Cell death & disease 19 38806484
2023 Syntaphilin Regulates Neutrophil Migration in Cancer. Cancer immunology research 19 36548516
2010 The triphenyltin(VI) complexes of NSAIDs and derivatives. Synthesis, crystal structure and antiproliferative activity. Potent anticancer agents. Journal of inorganic biochemistry 18 21194618
2021 Dl-3-n-Butylphthalide Alleviates Demyelination and Improves Cognitive Function by Promoting Mitochondrial Dynamics in White Matter Lesions. Frontiers in aging neuroscience 17 33762923
2019 Come and eat: mitochondrial transport guides mitophagy in ischemic neuronal axons. Autophagy 17 31095452
2019 Inappropriate Intrusion of an Axonal Mitochondrial Anchor into Dendrites Causes Neurodegeneration. Cell reports 16 31618636
2022 Perisciatic Nerve Dexmedetomidine Alleviates Spinal Oxidative Stress and Improves Peripheral Mitochondrial Dynamic Equilibrium in a Neuropathic Pain Mouse Model in an AMPK-Dependent Manner. Disease markers 13 35769812
2011 Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 13 21426264
2023 Expression and subcellular localization of mitochondrial docking protein, syntaphilin, in oligodendrocytes and CNS myelin sheath. Glia 12 37272718
2022 Tin-loaded mesoporous silica nanoparticles: Antineoplastic properties and genotoxicity assessment. Biomaterials advances 12 35929256
1996 Bonding Properties of a Novel Inorganometallic Complex, Ru(SnPh(3))(2)(CO)(2)(iPr-DAB) (iPr-DAB = N,N'-Diisopropyl-1,4-diaza-1,3-butadiene), and its Stable Radical-Anion, Studied by UV-Vis, IR, and EPR Spectroscopy, (Spectro-) Electrochemistry, and Density Functional Calculations. Inorganic chemistry 11 11666732
2023 Insight on the hub gene associated signatures and potential therapeutic agents in epilepsy and glioma. Brain research bulletin 9 37192718
2022 Tripartite Crosstalk between Cytokine IL-1β, NMDA-R and Misplaced Mitochondrial Anchor in Neuronal Dendrites Is a Novel Pathway for Neurodegeneration in Inflammatory Diseases. The Journal of neuroscience : the official journal of the Society for Neuroscience 9 35970564
2021 Syntaphilin downregulation facilitates radioresistance via mediating mitochondria distribution in esophageal squamous cell carcinoma. Free radical biology & medicine 8 33577962
2019 Syntaphilin Is a Novel Biphasic Biomarker of Aggressive Prostate Cancer and a Metastasis Predictor. The American journal of pathology 7 31079810
2016 Dramatic mechanistic switch in Sn/Au(I) group exchanges: transmetalation vs. oxidative addition. Chemical communications (Cambridge, England) 7 26960420
2023 Syntaphilin Inactivation Can Enhance Axonal Mitochondrial Transport to Improve Spinal Cord Injury. Molecular neurobiology 6 37458986
2025 S100A8/A9 innate immune signaling as a distinct mechanism driving progression of smoking-related breast cancers. Oncogene 5 39856330
2023 Roles of syntaphilin and armadillo repeat-containing X-linked protein 1 in brain injury after experimental intracerebral hemorrhage. Neuroscience letters 4 37187340
2011 [Management of secondary normal pressure hydrocephalus and assessment of cortical reorganization using fMRI]. No shinkei geka. Neurological surgery 3 21447851
2010 Diorganotin complexes of a thiosemicarbazone, synthesis: properties, x-ray crystal structure, and antiproliferative activity of diorganotin complexes. Bioinorganic chemistry and applications 3 20689713
2024 Short report: Twins with 20p13 duplication. Case report and comprehensive literature review. Molecular genetics & genomic medicine 2 38738460
2024 Reprogramming miR-146b-snphb Signaling Activates Axonal Mitochondrial Transport in the Zebrafish M-cell and Facilitates Axon Regeneration After Injury. Neuroscience bulletin 2 39645618
2023 Tin(II) and Tin(IV) Complexes Incorporating the Oxygen Tripodal Ligands [(η5-C5R5)Co{P(OEt)2O}3]-, (R = H, Me; Et = -C2H5) as Potent Inflammatory Mediator Inhibitors: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin. Molecules (Basel, Switzerland) 2 36838847
2023 Application of LRG mechanism in normal pressure hydrocephalus. Heliyon 2 38223707
2018 Monoclinic polymorph of chlorido-(dimethyl sulfoxide-κO)tri-phenyl-tin(IV). Acta crystallographica. Section E, Crystallographic communications 2 29850045
2017 Triphenyltin derivatives of sulfanylcarboxylic esters. Journal of inorganic biochemistry 2 29291491
2026 Bisphenol-A impairs hippocampal neurogenesis by disrupting Kinesin-1-dependent mitochondrial trafficking. The Journal of biological chemistry 0 41839425
2026 HIF-1α suppresses SNPH expression to facilitate liver metastasis of colorectal cancer through regulating mitochondrial dynamics and filopodia formation. Cell death & disease 0 41888092
2026 Buyang Huanwu decoction promotes neurological recovery after ischemic stroke by activating the Akt/PAK5/SNPH axis to enhance mitochondrial recruitment and axonal remodeling. Journal of ethnopharmacology 0 42134501
2025 Identification of Thyroid Genes Whose Expression Is Altered by Neonatal Irradiation in Rats. International journal of molecular sciences 0 40076501
2025 Multivariate genome-wide association study of suicidal behaviors in >1.7 million individuals of diverse population descents. medRxiv : the preprint server for health sciences 0 41445618
2024 Secondary normal pressure hydrocephalus following pituitary apoplexy: A case report. Surgical neurology international 0 38628523
2019 Antitumor effects of the electromagnetic resonant frequencies derived from the 1H NMR spectrum of Ph3Sn(Mercaptonicotinic)SnPh3 complex. Medical hypotheses 0 31563097
2002 Differential effect of Bacillus firmus on immune response and enterocyte brush-border enzyme levels in BALB/c and B10.BR mice. Folia microbiologica 0 12630333
1980 The synthesis of poly-L-lysine-succinyl-NADP: an analogue for NADP/H. The International journal of artificial organs 0 7461863

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