Affinage

SLCO1C1

Solute carrier organic anion transporter family member 1C1 · UniProt Q9NYB5

Length
712 aa
Mass
78.7 kDa
Annotated
2026-04-28
50 papers in source corpus 18 papers cited in narrative 18 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLCO1C1 (OATP1C1) is the principal thyroxine (T4) transporter at the blood-brain barrier, mediating high-affinity T4 uptake (Km ~0.34 µM) into the central nervous system and thereby controlling local thyroid hormone availability for brain development, myelination, and neurogenesis (PMID:15166123, PMID:22294745, PMID:24691440). The transporter localizes to both luminal and abluminal membranes of brain capillary endothelial cells and to the basolateral surface of choroid plexus and retinal pigment epithelium, and its transport function depends on conserved transmembrane residues including W277/W278 and requires proper N-glycosylation and plasma membrane targeting (PMID:18687783, PMID:20881245, PMID:24083450). Loss of OATP1C1 in mice causes brain-specific hypothyroidism with impaired myelination, disrupted GABAergic interneuron differentiation, defective adult hippocampal neurogenesis, and compromised skeletal muscle satellite cell activation, phenotypes dramatically worsened by combined loss of MCT8 (PMID:24691440, PMID:35159334, PMID:29706500). In humans, a homozygous D252N missense mutation in OATP1C1 causes juvenile neurodegeneration with brain hypometabolism (PMID:30296914).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2004 High

    Identifying the substrate selectivity of OATP1C1 established it as a high-affinity T4/rT3 transporter, distinguishing it from other OATPs that preferentially transport T3 or bile acids.

    Evidence Radiolabeled substrate uptake in HEK293 cells expressing mouse Oatp14, with kinetic analysis and inhibitor profiling

    PMID:15166123

    Open questions at the time
    • Human OATP1C1 kinetics not directly measured in this study
    • Endogenous regulators of transport activity unknown
  2. 2008 High

    Determining the precise subcellular localization of OATP1C1 at luminal and abluminal BBB membranes and basolateral choroid plexus resolved how T4 traverses the blood-brain and blood-CSF barriers, while also revealing species differences (low/absent expression in human microvessels).

    Evidence qRT-PCR, Western blot of isolated microvessels, and immunofluorescence in human, mouse, and rat brain

    PMID:18687783

    Open questions at the time
    • Human BBB expression discrepancy raises questions about compensatory mechanisms
    • Post-translational regulation of membrane targeting not addressed
  3. 2010 High

    Structure-function mutagenesis identified W277/W278 as essential for T4 transport and mapped additional residues (G399/G409, R601, P609) to substrate binding and translocation, providing the first molecular model of the OATP1C1 transport mechanism.

    Evidence Site-directed mutagenesis of nine residues with 125I-T4 uptake assays in HEK293 cells; homology modeling on MFS transporter templates

    PMID:20881245

    Open questions at the time
    • No experimental structure; model relies on distant MFS homology
    • Mechanism of substrate translocation conformational change not resolved
  4. 2012 High

    The Oatp1c1 single-knockout mouse demonstrated that OATP1C1 is necessary for maintaining normal brain T4/T3 levels and T3-responsive gene expression despite normal serum thyroid hormones, establishing it as a non-redundant BBB T4 gate.

    Evidence Oatp1c1 KO mice; brain TH content, deiodinase activities, and qPCR of TH target genes

    PMID:22294745

    Open questions at the time
    • Phenotypic severity relatively mild compared to double KO, leaving MCT8 compensation unclear
    • No behavioral or developmental phenotyping in single KO at this stage
  5. 2013 High

    Discovery that OATP1C1 mediates astrocyte-specific uptake of sulforhodamine 101 expanded its known substrate repertoire beyond thyroid hormones and identified it as a determinant of cell-type-specific dye labeling in neuroscience.

    Evidence Oatp1c1 KO mice; two-photon microscopy; region-specific astrocyte transcriptomics

    PMID:24129767

    Open questions at the time
    • Structural basis for SR101 recognition versus T4 recognition unknown
    • Whether SR101 transport reflects a physiological organic anion substrate remains unclear
  6. 2014 High

    The Mct8/Oatp1c1 double-knockout mouse revealed that OATP1C1 is the critical compensatory T4 entry route when MCT8 is absent, and combined loss produces severe CNS hypothyroidism with compromised cerebellar development, myelination, and GABAergic interneuron differentiation.

    Evidence Double-KO mouse with brain TH measurement, histological analysis of cerebellum, myelin, cortical interneurons, and locomotor behavioral testing

    PMID:24691440

    Open questions at the time
    • Cell-autonomous versus non-cell-autonomous contributions of each transporter to specific phenotypes not fully dissected
    • Temporal windows of vulnerability not defined
  7. 2015 Medium

    Demonstrating that LPS-induced inflammation rapidly downregulates OATP1C1 in BBB endothelium established a mechanism by which systemic infection could reduce brain T4 supply, linking innate immunity to central thyroid hormone economy.

    Evidence In situ hybridization, qPCR, and immunofluorescence for OATP1C1 in rat and mouse forebrain after LPS injection

    PMID:25594699

    Open questions at the time
    • Transcription factor(s) mediating LPS-dependent downregulation not identified
    • Functional consequence on brain TH levels not directly measured
  8. 2018 High

    Identification of a human homozygous D252N mutation in OATP1C1 causing impaired plasma membrane localization, reduced T4 uptake, and juvenile neurodegeneration established SLCO1C1 as a Mendelian disease gene and confirmed its non-redundant role in the human brain.

    Evidence Exome sequencing of affected patient; in vitro T4 uptake and immunocytochemistry of mutant protein

    PMID:30296914

    Open questions at the time
    • Only a single family reported; additional patients needed to define phenotypic spectrum
    • Whether residual transporter activity exists in vivo is unknown
  9. 2018 High

    Showing that OATP1C1 (with MCT8) gates thyroid hormone entry into satellite cells during skeletal muscle regeneration extended OATP1C1 function beyond the CNS to stem cell biology in peripheral tissues.

    Evidence Global and satellite cell-specific conditional Mct8/Oatp1c1 double-KO mice; muscle regeneration histology and TH-regulated gene expression

    PMID:29706500

    Open questions at the time
    • Individual contribution of OATP1C1 versus MCT8 in satellite cells not resolved
    • Mechanism of upregulation during activation unknown
  10. 2020 Medium

    A zebrafish oatp1c1 mutant demonstrated conserved transporter function across vertebrates and revealed HPT axis hyperactivation and radial glial/axonal defects, providing a non-mammalian model for OATP1C1 deficiency.

    Evidence Zebrafish oatp1c1 mutant; HPT axis and thyroid morphology analysis; locomotor behavior; immunofluorescence neuropathology

    PMID:31797746

    Open questions at the time
    • Zebrafish BBB organization differs from mammals; direct translational relevance uncertain
    • Compensatory transporters in zebrafish brain not characterized
  11. 2022 Medium

    Analysis of adult hippocampal neurogenesis in Oatp1c1 single-KO mice pinpointed a specific defect in the neuroblast-to-immature neuron transition, attributable to OATP1C1 alone rather than combined MCT8 loss.

    Evidence Oatp1c1 single-KO and double-KO mice; EdU labeling; stage-specific neurogenic marker immunofluorescence in dentate gyrus

    PMID:35159334

    Open questions at the time
    • Downstream T3-responsive transcriptional programs in neuroblasts not identified
    • Whether the defect is cell-autonomous in neuroblasts or mediated by niche cells is unclear
  12. 2025 Medium

    Mct8/Oatp1c1 double-KO mice exhibit increased seizure susceptibility linked to impaired GABAergic, glutamatergic, and cholinergic development; conditional neuron-specific deletion does not reproduce this, indicating the phenotype arises from global TH deficit rather than neuronal transporter function.

    Evidence Pilocarpine seizure model; neurotransmitter system marker analysis; global versus neuron-specific conditional KO comparison

    PMID:39986448

    Open questions at the time
    • Which non-neuronal cell types (endothelial, glial) are responsible for the TH supply deficit driving seizure susceptibility is unresolved
    • Whether OATP1C1 alone contributes to seizure phenotype independent of MCT8 is not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key open questions include the high-resolution structure of OATP1C1 with bound T4, the regulatory mechanisms controlling its expression at the BBB (including inflammation-responsive transcription factors), whether additional human patients with SLCO1C1 mutations exist, and the individual contribution of OATP1C1 versus MCT8 to each neurodevelopmental phenotype.
  • No experimental or cryo-EM structure available
  • Full phenotypic spectrum of human OATP1C1 deficiency unknown from a single case
  • Cell-type-specific conditional OATP1C1-only KO studies in brain are lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 6
Localization
GO:0005886 plasma membrane 4
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-112316 Neuronal System 2
Partners
MCT8

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 Mouse Oatp14 (SLCO1C1 ortholog) transports T4 and rT3 with high affinity (Km ~0.34 and ~0.46 µM, respectively) and T3 with ~4-fold lower affinity, as demonstrated by functional expression in HEK293 cells; taurocholate, probenecid, and estrone-3-sulfate were identified as moderate inhibitors, while digoxin and benzylpenicillin had no effect. Functional expression in HEK293 cells with radiolabeled substrate uptake assays; in situ brain perfusion technique in mice; Western blot of brain capillaries and choroid plexus; immunohistochemistry Endocrinology High 15166123
2008 OATP1C1 (SLCO1C1) mRNA and protein are strongly enriched in mouse and rat cerebral microvessels (blood-brain barrier) but not in human microvessels; in rat, Oatp14 protein localizes to both luminal and abluminal microvessel membranes, and in choroid plexus it localizes primarily to the basolateral surface. Quantitative RT-PCR, Western blot of isolated cerebral microvessels, immunofluorescence localization in brain sections and choroid plexus from human, mouse, and rat Endocrinology High 18687783
2012 Oatp1c1 knockout mice show decreased brain T4 and T3 content, increased type 2 and decreased type 3 deiodinase activities in brain (indicating mild central hypothyroidism), and down-regulated T3-regulated gene expression in brain, despite normal serum TH levels; this demonstrates that Oatp1c1 specifically facilitates T4 transport across the blood-brain barrier. Genetic knockout mouse model; brain TH content measurement; deiodinase activity assays; qPCR of TH-regulated target genes; serum TH measurements Endocrinology High 22294745
2014 OATP1C1 transports T4 (prohormone) across the blood-brain barrier; Mct8/Oatp1c1 double-knockout mice show strongly reduced uptake of both T3 and T4 into the brain (unlike single Mct8 KO where T4 entry is preserved via OATP1C1), resulting in severe CNS TH deprivation, compromised cerebellar development, reduced myelination, pronounced locomotor abnormalities, and impaired GABAergic interneuron differentiation. Double-knockout mouse model; brain TH content measurement; deiodinase activity assays; TH target gene expression; histological analysis of cerebellar development, myelination, and cortical interneurons; locomotor behavioral tests The Journal of clinical investigation High 24691440
2013 OATP1C1 (SLCO1C1) mediates cell-specific sulforhodamine 101 (SR101) uptake in hippocampal and cortical astrocytes, as demonstrated by transcriptome analysis of region-specific astrocytes, two-photon microscopy, and mouse genetics using Oatp1c1-deficient mice. Region-specific astrocyte isolation with transcriptome analysis, two-photon excitation microscopy, Oatp1c1 knockout mouse genetics Brain structure & function High 24129767
2010 Site-directed mutagenesis of Oatp1c1 identified key residues for T4 transport: W277A/W278A mutation abolished transport; W277F/W278F increased high-affinity Km ~10-fold; G399A/G409A and G399V/G409V mutants showed diminished T4 transport at high substrate concentrations (suggesting substrate binding site collapse); R601S and P609A (transmembrane domain 11) showed partial activity with reduced Vmax and higher Km. A 3D structural model was generated using MFS transporter templates, revealing evolutionary conservation with bacterial MFS members. Site-directed mutagenesis of nine residues; transient transfection in HEK293 cells; 125I-T4 transport uptake assays; plasma membrane localization assessment; homology modeling using MFS transporter crystal structures Endocrinology High 20881245
2018 A homozygous missense mutation (D252N) in OATP1C1 in a human patient causes impaired plasma membrane localization of the mutant protein and decreased cellular thyroxine uptake in vitro, associated with brain-specific hypothyroidism and juvenile neurodegeneration. Exome sequencing; in vitro thyroxine uptake studies; immunoblotting; immunocytochemistry for plasma membrane localization Thyroid High 30296914
2016 SR101 oligodendrocyte labeling depends on OATP1C1-mediated uptake into astrocytes followed by transfer to oligodendrocytes via heterotypic gap junctions; competitive inhibition of OATP1C1 by L-thyroxin significantly reduced oligodendrocyte SR101 labeling, demonstrating that OATP1C1 is the primary transporter mediating SR101 astrocyte entry. Pharmacological inhibition with L-thyroxin (competitive inhibitor of OATP1C1); SR101 labeling in hippocampal slices of PLP-EGFP mice; fluorescence microscopy Neuroscience letters Medium 27519929
2017 Xenopus oatp1c1 transports T4 but not T3, MIT, or DIT, consistent with mammalian OATP1C1 substrate selectivity, as demonstrated by radiolabeled hormone uptake assay in COS-1 cells; temporal and spatial expression in Xenopus brain increases during development. Cloning of Xenopus oatp1c1; radiolabeled hormone in vitro uptake assay in COS-1 cells; RT-qPCR; in situ hybridization Endocrinology Medium 28591769
2015 LPS-induced endotoxemia causes robust downregulation of OATP1C1 mRNA specifically in brain blood vessels within 9 hours, followed by upregulation at 24-48 hours, with OATP1C1 protein decreasing markedly in vessels by 24 hours; OATP1C1 mRNA in astrocytes was unchanged. This demonstrates inflammation-dependent regulation of OATP1C1 expression at the BBB. In situ hybridization, qPCR, and immunofluorescence for OATP1C1 mRNA and protein in rat and mouse forebrain after LPS injection; cell-type-specific analysis Endocrinology Medium 25594699
2018 MCT8 and OATP1C1 are both upregulated in activated satellite cells during skeletal muscle regeneration; Mct8/Oatp1c1 double-knockout mice showed strongly reduced numbers of differentiated satellite cells and impaired skeletal muscle regeneration; conditional deletion of both transporters exclusively in satellite cells also impaired regeneration, demonstrating a gate-keeper function for these transporters in myogenic stem cell activation. Mct8/Oatp1c1 double-knockout mouse analysis; satellite cell-specific conditional knockout; satellite cell isolation; tissue TH content measurement; TH-regulated gene expression; histological muscle regeneration assays Stem cell reports High 29706500
2021 OATP1C1 and MCT8 are strongly expressed in adult mouse subventricular zone neural stem cells (NSCs); Mct8/Oatp1c1 double-knockout mice show severely affected NSC proliferation and determination to neuronal (but not oligodendroglial) fates in the SVZ, establishing a role for OATP1C1 in adult neurogenesis. Immunofluorescence localization in adult mouse SVZ; Mct8/Oatp1c1 double-knockout mouse analysis; bromodeoxyuridine lineage tracing; cell fate marker analysis Stem cell reports Medium 33450189
2013 Oatp1c1 localizes to both luminal and abluminal membranes of retinal capillary endothelial cells and to the basolateral membrane of retinal pigment epithelial cells at the blood-retinal barrier, as demonstrated by immunoblot and immunohistochemistry with co-localization with GLUT1. Guinea pig polyclonal antibodies to Oatp1c1; immunoblot; immunohistochemistry with co-localization markers in rat retina Fluids and barriers of the CNS Medium 24083450
2019 OATP1C1 transports multiple fluorescent substrates including sulforhodamine 101, sulforhodamine G, sulforhodamine B, Live/Dead Green, and Live-or-Dye 488 dyes, as demonstrated by uptake assays in HEK-293 and A431 cells overexpressing OATP1C1; OATP1C1 transport activity can be inhibited by third-generation P-gp inhibitors elacridar, tariquidar, and zosuquidar. Fluorescent dye uptake assays in OATP1C1-overexpressing HEK-293 and A431 cells; pharmacological inhibition studies The FEBS journal Medium 31770475
2024 Tetrabromobisphenol A (TBBPA), PFOS, PFOA, pentachlorophenol, and quercetin were identified as OATP1C1 inhibitors of T4 uptake; TBBPA was the most potent OATP1C1 inhibitor, more potent than reference chemicals. This was demonstrated using OATP1C1-overexpressing cell models with radiolabeled T4 uptake. Radiolabeled 125I-T4 uptake assay in OATP1C1-overexpressing cell lines; chemical inhibitor screen Archives of toxicology Medium 38761188
2020 In oatp1c1-deficient zebrafish, oatp1c1 is expressed in endothelial cells, neurons, and astrocytes; loss of oatp1c1 results in hyperactivity of the hypothalamic-pituitary-thyroid axis, structural alterations in radial glial cells, shorter neuronal axons, and enlarged thyroid gland (goiter); TH analogs (TRIAC) but not THs can reduce thyroid gland enlargement. Zebrafish oatp1c1 mutant generation; HPT axis activity measurement; behavioral locomotor assays; neuropathological analysis by immunofluorescence; pharmacological treatment with TH analogs Thyroid Medium 31797746
2022 Oatp1c1 gene expression is detected in subsets of progenitors, neurons, and niche cells in the adult dentate gyrus; absence of Oatp1c1 results in increased neuroblast numbers and reduced immature neuron numbers in 6-month-old Oatp1c1 knockout mice, indicating a specific role of Oatp1c1 in neuroblast-to-immature neuron transition in adult hippocampal neurogenesis. Oatp1c1 single-KO and Mct8/Oatp1c1 double-KO mouse analysis; EdU labeling for neuron production; immunofluorescence for neurogenic stage markers; open field anxiety behavior testing Cells Medium 35159334
2025 Mct8/Oatp1c1 double-knockout mice show increased seizure susceptibility (faster status epilepticus onset and more severe responses), associated with abnormal development of GABAergic, glutamatergic, and cholinergic systems in the hippocampus and ectopic somatostatin expression in CA3 neurons; conditional neuron-specific deletion does not replicate the phenotype, indicating these alterations stem from the global TH deficit rather than cell-autonomous transporter function. Pilocarpine seizure model; immunofluorescence; in situ hybridization; qPCR; conditional (neuron-specific) knockout mouse lines for validation Progress in neurobiology Medium 39986448

Source papers

Stage 0 corpus · 50 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier. Endocrinology 268 18687783
2014 Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis. The Journal of clinical investigation 220 24691440
1998 Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. The Journal of biological chemistry 210 9632674
2001 Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflugers Archiv : European journal of physiology 140 11713643
2004 Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. Endocrinology 125 15166123
1999 Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. The American journal of physiology 112 10198348
2012 Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain. Endocrinology 106 22294745
1997 Expression of the liver Na+-independent organic anion transporting polypeptide (oatp-1) in rats with bile duct ligation. Journal of hepatology 81 9453431
1998 Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione. Seminars in liver disease 73 9875555
2003 Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake. American journal of physiology. Gastrointestinal and liver physiology 62 12842829
2013 The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes. Brain structure & function 61 24129767
2013 GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis. Pharmacogenomics 59 23651021
2018 Mutated Thyroid Hormone Transporter OATP1C1 Associates with Severe Brain Hypometabolism and Juvenile Neurodegeneration. Thyroid : official journal of the American Thyroid Association 56 30296914
2000 Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X. The Biochemical journal 56 10600646
2000 Down-regulation by extracellular ATP of rat hepatocyte organic anion transport is mediated by serine phosphorylation of oatp1. The Journal of biological chemistry 48 10625701
2001 Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2. Hepatology (Baltimore, Md.) 42 11391536
2002 Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17beta-D-glucuronide in rats. American journal of physiology. Endocrinology and metabolism 39 12006354
2013 Localization of organic anion transporting polypeptide (Oatp) 1a4 and Oatp1c1 at the rat blood-retinal barrier. Fluids and barriers of the CNS 36 24083450
2003 N-glycosylation controls functional activity of Oatp1, an organic anion transporter. American journal of physiology. Gastrointestinal and liver physiology 33 12702494
2015 Parallel regulation of thyroid hormone transporters OATP1c1 and MCT8 during and after endotoxemia at the blood-brain barrier of male rodents. Endocrinology 31 25594699
2018 Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration. Stem cell reports 30 29706500
2019 A novel fluorescence-based functional assay for human OATP1A2 and OATP1C1 identifies interaction between third-generation P-gp inhibitors and OATP1A2. The FEBS journal 26 31770475
2021 Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone. Stem cell reports 24 33450189
2014 Oatp1 enhances bioluminescence by acting as a plasma membrane transporter for D-luciferin. Molecular imaging and biology 22 24798747
2001 Functional analysis and androgen-regulated expression of mouse organic anion transporting polypeptide 1 (Oatp1) in the kidney. Biochimica et biophysica acta 22 11267661
2007 Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver. Liver international : official journal of the International Association for the Study of the Liver 21 17845533
2002 Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2. Hepatology (Baltimore, Md.) 21 11981753
2021 Single-Cell Transcriptome Profiling of Thyroid Hormone Effectors in the Human Fetal Neocortex: Expression of SLCO1C1, DIO2, and THRB in Specific Cell Types. Thyroid : official journal of the American Thyroid Association 20 34114484
2016 Unspecific labelling of oligodendrocytes by sulforhodamine 101 depends on astrocytic uptake via the thyroid hormone transporter OATP1C1 (SLCO1C1). Neuroscience letters 20 27519929
2022 TRIAC Treatment Improves Impaired Brain Network Function and White Matter Loss in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice. International journal of molecular sciences 16 36555189
2010 Evidence of evolutionary conservation of function between the thyroxine transporter Oatp1c1 and major facilitator superfamily members. Endocrinology 16 20881245
2020 Neural Alterations and Hyperactivity of the Hypothalamic-Pituitary-Thyroid Axis in Oatp1c1 Deficiency. Thyroid : official journal of the American Thyroid Association 14 31797746
2009 Characterization of the mechanisms involved in the increased renal elimination of bromosulfophthalein during cholestasis: involvement of Oatp1. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 14 19153193
2002 The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane. Molecular pharmacology 14 11809868
2023 Single nucleotide polymorphisms in ADAM17, IL23R and SLCO1C1 genes protect against infliximab failure in adults with Crohn's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 12 36621146
2022 Distinct Actions of the Thyroid Hormone Transporters Mct8 and Oatp1c1 in Murine Adult Hippocampal Neurogenesis. Cells 10 35159334
2017 Functional Characterization of Xenopus Thyroid Hormone Transporters mct8 and oatp1c1. Endocrinology 10 28591769
2022 Tsh Induces Agrp1 Neuron Proliferation in Oatp1c1-Deficient Zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience 9 36150888
2007 Hepatocyte growth factor increases uptake of estradiol 17beta-D-glucuronide and Oatp1 protein level in rat hepatocytes. European journal of pharmacology 9 18031729
2024 Arachidonic acid enhances hepatocyte bile acid uptake and alleviates cholestatic liver disease by upregulating OATP1 expression. Food & function 8 39258405
2023 Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Projection Neurons and Interneurons of Basal Ganglia and Motor Thalamus in the Adult Human and Macaque Brains. International journal of molecular sciences 8 37298594
2024 Two novel in vitro assays to screen chemicals for their capacity to inhibit thyroid hormone transmembrane transporter proteins OATP1C1 and OAT4. Archives of toxicology 6 38761188
2014 PDE3A-SLCO1C1 locus is associated with response to anti-tumor necrosis factor therapy in psoriatic arthritis. Pharmacogenomics 6 25493569
2023 Proteome Analysis of Thyroid Hormone Transporter Mct8/Oatp1c1-Deficient Mice Reveals Novel Dysregulated Target Molecules Involved in Locomotor Function. Cells 3 37887331
2021 Hepatic and renal expression of Oatp1 in obstructive uropathy. First detection of Oatp1 in urine, a potential biomarker. Clinical and experimental pharmacology & physiology 3 33738813
2019 Differential expression and immunoreactivity of thyroid hormone transporters MCT8 and OATP1C1 in rat ovary. Acta histochemica 3 31561916
2025 Sciatic nerve analysis in thyroid hormone transporters Mct8 and Oatp1c1 knockout mice. European thyroid journal 1 39812369
2025 Increased seizure susceptibility in thyroid hormone transporter Mct8/Oatp1c1 knockout mice is associated with altered neurotransmitter systems development. Progress in neurobiology 1 39986448
2024 Development of an OATP1-humanized transchromosomic mouse model for prediction of hepatic drug uptake in humans. Drug metabolism and disposition: the biological fate of chemicals 1 40023577
2026 Neuron-specific expression of murine thyroid hormone transporters Mct8 and Oatp1c1 is dispensable for hippocampus-dependent neuronal functions. Frontiers in endocrinology 0 41924522