Affinage

SLC5A1

Sodium/glucose cotransporter 1 · UniProt P13866

Length
664 aa
Mass
73.5 kDa
Annotated
2026-04-28
100 papers in source corpus 39 papers cited in narrative 37 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC5A1 encodes SGLT1, a Na⁺/glucose cotransporter that harnesses the inward Na⁺ electrochemical gradient to drive secondary active uptake of glucose and galactose across the apical membrane of intestinal enterocytes, renal proximal tubule S3 segments, macula densa cells, and certain neurons, while simultaneously functioning as a high-capacity passive water channel (PMID:1449065, PMID:11251046, PMID:26945065). Plasma-membrane abundance of SGLT1 is rate-limiting and dynamically controlled: a large intracellular microtubule-associated reserve pool undergoes regulated exocytic insertion in response to GLP-2, EGF, and multiple kinases (SGK1/3, PKB, AMPK, JAK2) that converge on the ubiquitin ligase Nedd4-2 and the Golgi gatekeeper RS1, while transcription is driven by HNF1α/Sp1 and modulated by the circadian clock proteins PER1/CLOCK (PMID:9435650, PMID:15166308, PMID:26464324, PMID:26377793, PMID:12773314). SGLT1-mediated glucose sensing at the macula densa upregulates NOS1-derived nitric oxide to attenuate tubuloglomerular feedback, a mechanism that drives glomerular hyperfiltration in diabetes, and in the intestine SGLT1 is the obligate sensor for glucose-induced GIP and GLP-1 incretin secretion (PMID:30867247, PMID:31091127, PMID:24587162). Loss-of-function missense mutations (e.g., D28N, G318R, A468V) that impair trafficking to the plasma membrane cause autosomal recessive glucose–galactose malabsorption (PMID:1449065, PMID:10036327).

Mechanistic history

Synthesis pass · year-by-year structured walk · 20 steps
  1. 1991 High

    Establishing where SGLT1 operates: prior to tissue-level localization it was unclear which cell types and membrane domains express the transporter; in situ hybridization and immunocytochemistry showed SGLT1 is restricted to the brush-border membrane of mature villus enterocytes, establishing its polarized apical distribution.

    Evidence In situ hybridization and immunocytochemistry on rabbit small intestine sections

    PMID:1764071

    Open questions at the time
    • Protein trafficking pathway from biosynthesis to brush border not addressed
    • Expression in non-intestinal tissues not examined
  2. 1992 High

    Defining the transport mechanism and disease-causing residues: cDNA expression in oocytes established SGLT1 as a 12-transmembrane-helix Na⁺/glucose cotransporter and identified D28 and R300 as essential residues, with D28N causing glucose–galactose malabsorption — the first direct genotype-to-phenotype link.

    Evidence cDNA cloning, Xenopus oocyte expression, site-directed mutagenesis, electrophysiology

    PMID:1449065

    Open questions at the time
    • Three-dimensional structure unknown
    • Stoichiometry of Na⁺:glucose coupling not resolved at atomic level
  3. 1994 High

    Gene architecture revealed: the complete 15-exon, 72-kb gene on 22q11.2 was characterized, suggesting an evolutionary origin by internal duplication of a 6-TM precursor and locating additional GGM-causing mutations.

    Evidence Genomic cloning, restriction mapping, sequencing, somatic cell hybrid chromosomal mapping

    PMID:8195156

    Open questions at the time
    • Regulatory elements beyond the coding region not characterized
    • Promoter elements not defined
  4. 1997 High

    Two key contextual expansions: (1) GLP-2 was shown to rapidly recruit SGLT1 from an intracellular reserve pool to the brush border via PI3K-dependent trafficking, establishing that membrane insertion — not transcription — acutely controls transport capacity; (2) neuronal SGLT1 expression was documented in brain with upregulation during seizure.

    Evidence Brush-border membrane vesicle isolation with phlorizin binding and inhibitor studies in vivo; immunohistochemistry and autoradiography across species

    PMID:9202297 PMID:9435650

    Open questions at the time
    • Identity of the intracellular compartment not determined
    • Neuronal SGLT1 functional role not defined beyond expression
  5. 1999 High

    Trafficking as the disease mechanism: GGM-causing mutations G318R and A468V produce core-glycosylated protein trapped in the ER, showing that loss-of-function results from failed plasma membrane delivery rather than protein instability.

    Evidence Oocyte expression with pre-steady-state current measurement, Western blot, radiotracer uptake

    PMID:10036327

    Open questions at the time
    • ER quality control machinery involved not identified
    • Whether pharmacological chaperones can rescue trafficking not tested
  6. 2001 High

    Two fundamental properties clarified: (1) SGLT1 cotransports ~264 water molecules per sugar cycle and also acts as a passive water channel, quantifying its role in intestinal fluid absorption; (2) HNF-1 binding at the minimal promoter is required for basal and glucose-induced SGLT1 transcription.

    Evidence Oocyte volume measurements with electrophysiology; promoter deletion/mutagenesis with EMSA and reporter assays

    PMID:11251046 PMID:11606209

    Open questions at the time
    • Structural basis of the water pathway unknown
    • HNF-1 interplay with other transcription factors not resolved
  7. 2002 High

    Membrane-domain and cytoskeletal requirements defined: vimentin was shown to be necessary for SGLT1 localization in lipid rafts and full transport activity, and EGF was found to stimulate actin-dependent SGLT1 insertion into the brush border, establishing cytoskeletal control of surface delivery.

    Evidence Vimentin-null mouse proximal tubular cells with raft fractionation and cholesterol rescue; rabbit jejunal loop with cytochalasin D inhibition

    PMID:11865027 PMID:12430982

    Open questions at the time
    • Direct vimentin–SGLT1 physical interaction not demonstrated
    • Actin remodeling signaling intermediates downstream of EGF not identified
  8. 2003 High

    The intracellular reserve pool was quantified: in polarized Caco-2 cells, ~2/3 of SGLT1 resides in a stable microtubule-associated intracellular compartment with a 2.5-day half-life, confirming regulated trafficking rather than de novo synthesis as the rapid-response mechanism.

    Evidence Free-flow electrophoresis fractionation, ELISA, confocal microscopy, cycloheximide chase

    PMID:12773314

    Open questions at the time
    • Molecular identity of the intracellular compartment (recycling endosome vs. Golgi-derived) not resolved
    • Signals triggering release from the pool not identified
  9. 2004 High

    Kinase–ubiquitin ligase regulatory axis identified: SGK1, SGK3, and PKB were shown to stimulate SGLT1 by phosphorylating and inactivating the ubiquitin ligase Nedd4-2, providing a molecular mechanism for hormonal upregulation of surface SGLT1.

    Evidence Oocyte coexpression with kinase-dead and Nedd4-2 phosphosite mutants, two-electrode voltage clamp

    PMID:15166308

    Open questions at the time
    • Direct ubiquitination of SGLT1 by Nedd4-2 not demonstrated
    • In vivo relevance of this axis in intestine or kidney not confirmed
  10. 2008 High

    Transcriptional and post-transcriptional regulation layers distinguished: Sp1/HNF1 synergy at the promoter was shown to drive transcription (reduced in inflammation), while capsaicin-sensitive vagal afferents were found to regulate SGLT1 protein rhythmicity post-transcriptionally without affecting mRNA, revealing dual-layer control.

    Evidence Promoter mutagenesis with EMSA; selective vagal deafferentation vs. total vagotomy with temporal protein/mRNA profiling

    PMID:18308853 PMID:18339704

    Open questions at the time
    • Post-transcriptional mechanism downstream of vagal afferents (translation vs. stability) unresolved
    • Identity of vagal neurotransmitter acting on SGLT1 not known
  11. 2010 High

    AMPK added to the kinase repertoire: constitutively active AMPK increased SGLT1 Vmax by promoting membrane insertion, linking cellular energy sensing to glucose absorption capacity.

    Evidence Oocyte coexpression with AMPK constructs, voltage clamp; Caco-2 membrane fractionation with AMPK activators

    PMID:20334581

    Open questions at the time
    • Whether AMPK acts through Nedd4-2 or an independent pathway not determined
    • Physiological stimulus activating AMPK in enterocytes not identified
  12. 2011 High

    Structure–function of the substrate-binding vestibule resolved: homology modeling guided mutagenesis showed sugar and phlorizin share the same binding site, F101 contacts the phloretin moiety, and external Na⁺ opens the vestibule gate, explaining the alternating-access mechanism.

    Evidence Homology modeling, SCAM, site-directed mutagenesis in oocytes, electrophysiology, phlorizin kinetics

    PMID:22159082

    Open questions at the time
    • No experimental high-resolution structure yet
    • Conformational dynamics during the transport cycle not directly observed
  13. 2013 Medium

    An unexpected kinase-independent EGFR interaction discovered: EGFR physically associates with SGLT1 in cancer cells via the EGFR autophosphorylation domain (978-1210), stabilizing SGLT1 independent of EGFR kinase activity, linking glucose uptake to oncogenic signaling.

    Evidence Co-immunoprecipitation with EGFR domain deletion constructs, pharmacological EGFR modulation, cell viability assays

    PMID:23765757

    Open questions at the time
    • Reciprocal SGLT1 domain mapping not performed
    • Whether the interaction is direct or mediated by an adaptor unknown
    • Single-lab finding
  14. 2014 High

    Two physiological roles clarified: (1) SGLT1, but not GLUT2, is the obligate sensor for glucose-induced incretin (GIP and GLP-1) secretion in vivo; (2) constitutive NO regulates SGLT1 glucose affinity via cGMP/PKG-dependent N-linked glycosylation, adding a post-translational control layer.

    Evidence SGLT1-KO vs. GLUT2-KO mice with glucose gavage and incretin measurements; IEC-18 transport kinetics with PNGase-F deglycosylation and metabolic labeling

    PMID:24412219 PMID:24587162

    Open questions at the time
    • Which enteroendocrine cell populations require SGLT1 not resolved at single-cell level
    • Specific glycosylation sites regulated by NO not identified
  15. 2015 High

    Multiple regulatory nodes refined: RS1 (RSC1A1) was identified as a Golgi gatekeeper whose phosphorylation-dependent release permits SGLT1 vesicle exocytosis after glucose ingestion; PER1/CLOCK were shown to bind SGLT1 promoters driving circadian transcription in renal tubule; VMH-specific SGLT1 knockdown enhanced counterregulatory responses to hypoglycemia.

    Evidence RS1 domain injection in oocytes with phosphosite mutagenesis; ChIP for PER1/CLOCK on SGLT1 promoter with siRNA and nuclear entry blockade; AAV-shRNA VMH injection with hypoglycemic clamp

    PMID:26130763 PMID:26377793 PMID:26464324

    Open questions at the time
    • RS1 phosphorylation kinase identity not established in vivo
    • Whether PER1 effect on SGLT1 is direct or through intermediate regulators not excluded
    • Central SGLT1 mechanism of glucose sensing unresolved
  16. 2016 High

    Water permeation quantified at single-molecule level: reconstituted SGLT1 has unitary water permeability comparable to AQP1, independent of substrate or voltage, establishing that passive osmotic water flux far exceeds any coupled water transport.

    Evidence SGLT1 reconstitution into proteoliposomes, MDCK monolayer expression, light-scattering osmotic assay, fluorescence correlation spectroscopy

    PMID:26945065

    Open questions at the time
    • Structural pathway for water through SGLT1 not identified
    • Physiological contribution of SGLT1 water permeation vs. aquaporins not quantified in vivo
  17. 2019 High

    Macula densa glucose sensing mechanism established: SGLT1 at the macula densa senses luminal glucose and upregulates NOS1, generating NO that blunts tubuloglomerular feedback; SGLT1-KO in diabetic mice attenuated hyperfiltration, glomerular hypertrophy, and albuminuria, directly implicating SGLT1 in diabetic kidney disease pathogenesis.

    Evidence Microperfusion/micropuncture with SGLT1 inhibitor KGA-2727, macula densa-specific NOS1-KO; SGLT1-KO in Akita diabetic mice with GFR, morphometry, albuminuria

    PMID:30867247 PMID:31091127

    Open questions at the time
    • Signal transduction from SGLT1-mediated glucose entry to NOS1 transcription not fully delineated
    • Whether SGLT1 blockade is renoprotective in human diabetes not tested
  18. 2020 High

    HNF1α–SGLT1 axis extended to pancreatic α-cells: HNF1α directly activates the Slc5a1 promoter in α-cells, and SGLT1 inhibition suppresses low-glucose-stimulated glucagon secretion, placing SGLT1 downstream of HNF1α in the glucagon secretory pathway.

    Evidence Hnf1a-KO mice, luciferase promoter assay, islet glucagon secretion assay with SGLT1 inhibitor

    PMID:32711050

    Open questions at the time
    • Mechanism by which SGLT1-mediated Na⁺/glucose entry triggers glucagon exocytosis not resolved
    • Relevance to HNF1α-MODY phenotype not established
  19. 2021 High

    Cardiac SGLT1 re-evaluated: the heart expresses a truncated SLC5A1 transcript lacking key transmembrane/binding domains, and SGLT1-KO mice show no cardiac glucose uptake defect, challenging earlier claims of functional cardiac SGLT1.

    Evidence SGLT1 exon-1 KO mice, isolated cardiomyocyte uptake, micro-PET, transcript sequencing

    PMID:33416451

    Open questions at the time
    • Whether the truncated transcript has any non-transport function not addressed
    • Applicability to human heart not confirmed
  20. 2022 High

    Atomic-resolution mechanism achieved: the cryo-EM structure of hSGLT1–MAP17 with inhibitor LX2761 revealed an outward-open conformation where the inhibitor occludes the substrate-binding vestibule and water pathway, providing a structural framework for the alternating-access transport cycle and competitive inhibitor design.

    Evidence Cryo-EM structural determination of hSGLT1–MAP17 complex

    PMID:36307403

    Open questions at the time
    • Inward-open and occluded-state structures not yet determined experimentally
    • Structural basis of water permeation pathway not fully resolved
    • MAP17 functional role in transport cycle unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the complete set of experimental structures across the transport cycle (inward-open, occluded states); the structural basis for simultaneous water permeation; whether direct Nedd4-2-mediated ubiquitination of SGLT1 occurs; the signal transduction pathway linking SGLT1-mediated glucose entry at the macula densa to NOS1 transcriptional upregulation; and the in vivo relevance of the SGLT1–EGFR interaction in cancer.
  • Full transport-cycle structural coverage lacking
  • Water permeation pathway unresolved structurally
  • In vivo ubiquitination of SGLT1 by Nedd4-2 not demonstrated

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 5 GO:0140299 molecular sensor activity 3
Localization
GO:0005886 plasma membrane 7 GO:0031410 cytoplasmic vesicle 3 GO:0005794 Golgi apparatus 1
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-382551 Transport of small molecules 5 R-HSA-9609507 Protein localization 5 R-HSA-8963743 Digestion and absorption 2 R-HSA-9909396 Circadian clock 2
Partners
EGFRHNF1AMAP17NEDD4LPER1RSC1A1SGK1VIM
Complex memberships
SGLT1–MAP17

Evidence

Reading pass · 37 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1992 SGLT1 is a Na+/glucose cotransporter with a 12 membrane-spanning helical model; N-linked glycosylation at Asn248 is not required for function; Asp28 and Arg300 are essential residues for functional expression, with missense mutation D28N causing glucose-galactose malabsorption. cDNA cloning, expression in Xenopus oocytes, site-directed mutagenesis, electrophysiology Acta physiologica Scandinavica. Supplementum High 1449065
1991 SGLT1 mRNA and protein are expressed along the villus but not in crypts of rabbit small intestine; SGLT1 protein is restricted to the brush borders of mature enterocytes, increasing from crypt-villus junction to villus tip. In situ hybridization, immunocytochemistry Biochemical and biophysical research communications High 1764071
1994 The human SGLT1 gene comprises 15 exons spanning 72 kilobases on chromosome 22q11.2-qter; structure suggests evolutionary origin from a six-membrane-span ancestral precursor via gene duplication; missense mutation in exon 1 causes glucose/galactose malabsorption. Genomic cloning, restriction mapping, sequencing, chromosomal mapping in somatic cell hybrids The Journal of biological chemistry High 8195156
1997 GLP-2 infusion in vivo induces trafficking of SGLT1 from an intracellular pool into the brush-border membrane within 60 minutes, producing a 3-fold increase in maximal transport rate; this effect is blocked by luminal brefeldin A or wortmannin, implicating phosphoinositol 3-kinase in the signaling pathway. Brush-border membrane vesicle isolation, kinetic analysis, sodium-dependent phloridzin binding, Western blotting, pharmacological inhibition in vivo The American journal of physiology High 9435650
1997 SGLT1 is expressed in neurons of rabbit, pig, and human brain (pyramidal cells of cortex/hippocampus, Purkinje cells of cerebellum); neuronal SGLT1 can be upregulated during epileptic seizure as shown by increased [14C]AMG uptake persisting >1 day post-seizure. In situ hybridization, immunohistochemistry, Western blotting with synaptosomal membranes, autoradiography of radiolabeled SGLT1 substrate Journal of neurochemistry High 9202297
1999 Missense mutations G318R and A468V in SGLT1 cause glucose-galactose malabsorption by defective trafficking of mutant proteins from the endoplasmic reticulum to the plasma membrane; both mutant proteins are core-glycosylated and present in total cell protein but absent from the plasma membrane as shown by pre-steady-state current measurements. SSCP analysis, sequencing, Xenopus oocyte expression, radiotracer uptake, two-electrode voltage clamp, Western blotting, pre-steady-state current measurement Biochimica et biophysica acta High 10036327
2001 SGLT1 cotransports water directly (264 water molecules per 2 Na+ and 1 sugar for human SGLT1; 424 for rabbit SGLT1) and also acts as a passive water channel; the cotransport is tightly coupled to sugar-induced current; coexpression with AQP1 enables near-instantaneous isotonic transport. Xenopus oocyte expression, electrophysiological voltage clamp, optical volume measurement The Journal of physiology High 11251046
2001 HNF-1 binding to the minimal SGLT1 promoter (-66/+21 bp) is required for basal promoter function and glucose-induced transcriptional activation; site-directed mutagenesis of the HNF-1 motif eliminates basal promoter activity; HNF-1 abundance declines coordinately with SGLT1 during ruminant maturation and is restored by glucose infusion. Deletion analysis, site-directed mutagenesis, luciferase reporter assays, DNA mobility-shift assays, Northern blotting European journal of biochemistry High 11606209
2002 Vimentin is required for localization of SGLT1 in detergent-resistant membrane microdomains (lipid rafts); absence of vimentin in Vim-/- renal proximal tubular cells dramatically decreases SGLT1 protein in DRM and Na-glucose cotransport activity; disrupting rafts with methyl-β-cyclodextrin recapitulates the Vim-/- phenotype; cholesterol supplementation restores transport activity in Vim-/- cells. Primary culture from vimentin-null mice, detergent-resistant membrane fractionation, Na-glucose transport assay, cholesterol depletion/repletion Journal of cell science High 11865027
2002 EGF stimulates translocation of SGLT1 from an internal microsomal pool into the brush border, increasing brush-border SGLT1 content and Vmax for glucose uptake; this effect requires actin polymerization and is abolished by cytochalasin D. Rabbit jejunal loop preparation, brush-border membrane vesicle Western blot, microsomal membrane Western blot, glucose kinetics, electron microscopy, pharmacological inhibition The American journal of physiology High 12430982 9950820
2003 In polarized Caco-2 cells, SGLT1 resides predominantly (~2:1 ratio) in intracellular compartments associated with microtubules rather than the apical membrane, representing a reserve pool; the intracellular pool is not simply newly synthesized protein (unchanged by cycloheximide); SGLT1 half-life is ~2.5 days. Free-flow electrophoresis fractionation, ELISA with epitope-specific antibodies, confocal microscopy, cycloheximide chase, metabolic labeling and immunoprecipitation American journal of physiology. Cell physiology High 12773314
2004 Nedd4-2 reduces SGLT1 activity; SGK1, SGK3, and PKB reverse Nedd4-2-mediated inhibition of SGLT1 by phosphorylating Nedd4-2; kinase-inactive mutants are without effect; deletion of SGK/PKB phosphorylation sites in Nedd4-2 blocks kinase effects on SGLT1. Xenopus oocyte co-expression, two-electrode voltage clamp (glucose-induced current), mutagenesis of Nedd4-2 phosphorylation sites, kinase phosphorylation assay Obesity research High 15166308
2008 Sp1 and HNF1 transcription factors act synergistically at the rabbit SGLT1 promoter (within 196 bp upstream of transcription start site) to drive SGLT1 transcription; binding of both factors is reduced during chronic intestinal inflammation, contributing to decreased SGLT1 expression. SGLT1 promoter cloning, deletion analysis, reporter assays, mobility shift assays (EMSA), chromatin analysis American journal of physiology. Gastrointestinal and liver physiology High 18339704
2010 AMPK activation (constitutively active γR70Q-AMPK) enhances SGLT1 maximal transport rate without changing substrate affinity; AICAR, phenformin, and A-769662 increase SGLT1 protein abundance in the plasma membrane of Caco2 cells, suggesting AMPK promotes membrane translocation of SGLT1. Xenopus oocyte co-expression with AMPK constructs, dual electrode voltage clamp, confocal microscopy, Western blotting of membrane fractions of Caco2 cells Molecular membrane biology High 20334581
2011 Homology modeling of hSGLT1 based on bacterial Na+ cotransporter structures, combined with mutagenesis of conserved gate and ligand-binding residues expressed in Xenopus oocytes, established that: (1) sugar and phlorizin share the same binding site; (2) F101 is involved in binding the phloretin moiety of phlorizin; (3) external Na+ opens the sugar-binding vestibule; (4) external gate residues are critical for efficient Na+/sugar cotransport stoichiometry. Homology modeling, site-directed mutagenesis, Xenopus oocyte expression, electrophysiology, SCAM (substituted-cysteine accessibility), phlorizin inhibition kinetics American journal of physiology. Cell physiology High 22159082
2012 Tau tubulin kinase 2 (TTBK2) increases SGLT1 membrane carrier protein abundance and electrogenic glucose transport capacity; this requires the full-length TTBK2 and its kinase activity, as truncated or kinase-dead mutants have no effect. Xenopus oocyte co-expression, dual electrode voltage clamp, kinase-dead and truncation mutants Cellular physiology and biochemistry Medium 22814243
2011 JAK2 (and the V617F gain-of-function mutant) increases SGLT1 maximal transport rate by enhancing carrier insertion into the plasma membrane (increased membrane protein abundance); kinase-inactive K882E-JAK2 has no effect; JAK2 inhibitor AG490 abrogates the stimulation. Xenopus oocyte co-expression, dual electrode voltage clamp, chemiluminescence membrane abundance assay, brefeldin A chase Biochemical and biophysical research communications Medium 21406183
2015 RS1 (RSC1A1) blocks exocytosis of SGLT1-containing vesicles from the Golgi via a phosphorylation-dependent mechanism in its RS1-Reg domain; glucose-dependent phosphorylation of RS1-Reg disinhibits SGLT1 exocytosis after glucose ingestion; RS1-Reg-derived peptides can downregulate intestinal brush-border SGLT1 at high luminal glucose concentrations. Injection of RS1 fragments into Xenopus oocytes expressing SGLT1, uptake assay, phosphorylation site mutagenesis, cell-based vesicle release assays Molecular pharmacology High 26464324
2015 Circadian clock protein PER1 transcriptionally regulates SGLT1 and NHE3 in renal proximal tubule cells; PER1 and CLOCK bind to SGLT1 and NHE3 promoters; blockade of PER1 nuclear entry decreases SGLT1 mRNA and protein (both membrane and intracellular) in mouse renal cortex and HK-2 cells. Pharmacological nuclear entry blockade, siRNA knockdown, ChIP assay, heterogeneous nuclear RNA analysis, immunoblotting of subcellular fractions, Na+-K+-ATPase activity American journal of physiology. Renal physiology High 26377793
2016 SGLT1 acts as an extremely efficient passive water channel with unitary water permeability (pf) similar to aquaporin-1; this pf is independent of glucose/Na+ presence, membrane voltage, or transport direction, indicating the water-impermeable occluded state is brief; passive osmotic flux through SGLT1 is orders of magnitude larger than any active water pumping. SGLT1 overexpression in MDCK monolayers, reconstitution into proteoliposomes, light scattering osmotic swelling assay, fluorescence correlation spectroscopy for protein abundance The Journal of biological chemistry High 26945065
2016 Canagliflozin competitively inhibits both SGLT1 (Ki = 770.5 nM) and SGLT2 (Ki = 4.0 nM) from the extracellular side; patch-clamp experiments show inhibition is preferentially from the extracellular (not intracellular) face; 14C-canagliflozin is partially transported by SGLT2. Stable cell lines expressing human SGLT1/SGLT2, competitive inhibition kinetics, whole-cell patch-clamp, radiolabeled substrate transport The Journal of pharmacology and experimental therapeutics High 27189972
2019 SGLT1 at the macula densa senses luminal glucose and upregulates NOS1 expression and activity, generating nitric oxide that blunts the tubuloglomerular feedback (TGF) response and promotes glomerular hyperfiltration; SGLT1 inhibitor KGA-2727 blocks this pathway; macula densa-specific NOS1 knockout abolishes the glucose-TGF-GFR axis. Microperfusion, micropuncture, renal clearance (FITC-inulin), macula densa-specific NOS1 KO mice, SGLT1 inhibitor KGA-2727 Journal of the American Society of Nephrology High 30867247
2019 SGLT1 knockout in diabetic Akita mice attenuates diabetes-induced glomerular hyperfiltration, upregulation of macula densa NOS1 expression, kidney weight increase, glomerular enlargement, and albuminuria; SGLT1 mediates glucose-driven MD-NOS1 upregulation contributing to diabetic hyperfiltration. SGLT1 gene knockout in Akita diabetic mice, FITC-inulin GFR measurement, NOS1 immunostaining, kidney morphometry, albuminuria measurement American journal of physiology. Renal physiology High 31091127
2014 Reduced constitutive nitric oxide (cNO) production inhibits SGLT1 activity by decreasing glucose affinity (Km shift) without changing Vmax; the mechanism involves altered N-linked glycosylation of SGLT1 via the cGMP/PKG signaling pathway; tunicamycin (glycosylation inhibitor) mimics the effect and reduces apparent SGLT1 molecular size from 75 kDa to 62 kDa. IEC-18 cells, transport kinetics, metabolic labeling and immunoprecipitation, PNGase-F deglycosylation, immunoblotting of luminal membranes Biochimica et biophysica acta High 24412219
2013 EGFR physically associates with and stabilizes SGLT1 in cancer cells; the EGFR autophosphorylation region (978-1210 aa) is required for sufficient EGFR-SGLT1 interaction; this interaction is independent of EGFR tyrosine kinase activity and does not respond to EGF or TKIs; SGLT1 inhibition sensitizes prostate cancer cells to EGFR inhibitors. Co-immunoprecipitation, EGFR domain deletion constructs, pharmacological EGFR modulation, cell viability assays with SGLT1 inhibitor The Prostate Medium 23765757
2019 SGLT1 depletion in triple-negative breast cancer cells decreases phospho-EGFR levels and inhibits downstream AKT and ERK signaling; SGLT1 knockdown reduces cell growth in vitro and in vivo, establishing SGLT1 as required for EGFR pathway maintenance in TNBC. siRNA knockdown, Western blotting for phospho-EGFR/AKT/ERK, in vitro proliferation, in vivo xenograft Molecular oncology Medium 31199048
2021 PKCδ-phosphorylated EGFR (at Thr678) interacts with and stabilizes SGLT1 protein in TKI-resistant NSCLC cells; SGLT1 upregulation increases glucose uptake and confers acquired EGFR TKI resistance; SGLT1 blockade overcomes this resistance in vitro and in vivo. Co-immunoprecipitation, phosphorylation site identification, SGLT1 KD/inhibition in TKI-resistant cell lines, in vivo xenografts, glucose uptake assays Oncogene Medium 34155348
2022 Cryo-EM structure of human SGLT1 in complex with its regulatory partner MAP17 bound to high-affinity inhibitor LX2761; LX2761 locks hSGLT1 in an outward-open conformation by wedging into the substrate-binding site and extracellular vestibule, blocking the putative water permeation pathway; conformational changes during outward-to-inward-open transitions are revealed. Cryo-EM structural determination of hSGLT1-MAP17 complex Nature communications High 36307403
2008 Capsaicin-sensitive vagal afferent fibers regulate posttranscriptional (but not transcriptional) control of intestinal SGLT1; total vagotomy or selective afferent deafferentation abolishes the diurnal rhythm in SGLT1 protein without affecting Sglt1 mRNA rhythm, and this is independent of the RS1 regulatory pathway. Selective capsaicin deafferentation vs. total vagotomy vs. sham surgery, quantitative PCR for Sglt1 and RS1 mRNA, immunoblotting at 6-h intervals American journal of physiology. Gastrointestinal and liver physiology Medium 18308853
2015 Reduction of SGLT1 expression in the ventromedial hypothalamus (VMH) by shRNA augments glucagon and epinephrine counterregulatory responses to hypoglycemia and increases hepatic glucose production; VMH SGLT1 knockdown also improves impaired counterregulatory responses in recurrently hypoglycemic and diabetic rats. AAV-shRNA bilateral VMH microinjection, hypoglycemic clamp, hormone measurements, tritiated glucose kinetics Diabetes High 26130763
2020 HNF1α directly activates the Slc5a1 (SGLT1) promoter in pancreatic α-cells; HNF1α deficiency reduces SGLT1 expression in islets; SGLT1 inhibition suppresses low-glucose-stimulated glucagon secretion in islets and αTC1-6 cells, and SGLT1 inhibition has no additional effect in HNF1α-deficient cells, placing SGLT1 downstream of HNF1α in glucagon secretion. Hnf1a knockout mice, luciferase promoter assay, islet glucagon secretion assay, SGLT1 inhibitor in αTC1-6 cells and isolated islets, gene expression analysis Biochimica et biophysica acta. Molecular basis of disease High 32711050
2021 Mouse and human hearts express a truncated slc5a1 transcript lacking transmembrane domains and residues involved in glucose and sodium binding; SGLT1 knockout mice (lacking exon 1) show no difference in cardiac glucose uptake under basal, insulin-stimulated, or hyperglycemic conditions; high-dose phlorizin inhibits cardiac glucose uptake by a GLUT (not SGLT1)-dependent mechanism. SGLT1 exon-1 knockout mice, isolated cardiomyocyte glucose uptake assay, in vivo micro-PET, phlorizin dose-response, transcript variant sequencing American journal of physiology. Heart and circulatory physiology High 33416451
2017 Upper small intestinal glucose sensing triggers an SGLT1-dependent pathway to lower hepatic glucose production in rodents; high-fat diet reduces SGLT1 expression and glucose sensing in the upper small intestine; metformin restores SGLT1 expression and glucose sensing; microbiota transplant from metformin-treated rats upregulates SGLT1 and restores glucose sensing. Upper small intestinal cannulation/infusion in rats, glucose production measurement, Western blotting for SGLT1, microbiota transplantation Cell metabolism Medium 29056513
2019 Gene deletion of SGLT1 in mice subjected to renal ischemia-reperfusion injury does not affect the initial injury but improves kidney recovery (lower plasma creatinine, higher GFR, reduced tubular injury score, lesser fibrosis markers) compared with wild-type, identifying SGLT1 activity in the late proximal tubule as deleterious during recovery. Sglt1 gene knockout mice, bilateral renal ischemia-reperfusion, FITC-sinistrin GFR, plasma creatinine, urinary KIM-1, renal mRNA markers, histological scoring American journal of physiology. Renal physiology High 30995111
2014 Incretin (GIP and GLP-1) secretion in response to intestinal glucose is abolished in SGLT1-deficient mice but not GLUT2-deficient mice, demonstrating that SGLT1 is the primary mediator of glucose-induced incretin secretion; SGLT1-deficient mice also show drastically reduced tissue retention of radiolabeled glucose throughout the small intestine. SGLT1-KO and GLUT2-KO mouse glucose gavage, radiotracer glucose tissue retention, plasma GIP, GLP-1, insulin measurements, apical membrane Western blotting PloS one High 24587162
2009 Diabetes increases SGLT1 mRNA expression in parotid and submandibular salivary glands and increases SGLT1 protein in the luminal membrane of ductal cells, which enhances water reabsorption from primary saliva and contributes to reduced salivary flow; insulin treatment reverses all alterations. Streptozotocin diabetic rat model, qRT-PCR, immunohistochemistry, salivary flow measurement, insulin reversal The Journal of membrane biology Medium 19238474
2011 High-starch/low-fat diet induction of SGLT1 gene expression in rat jejunum is associated with histone H3K4 mono-, di-, and trimethylation and binding of the histone acetyltransferase GCN5 at SGLT1 promoter/enhancer and transcribed regions, but not with H3K9/H4K20 methylation or HP1 binding. Chromatin immunoprecipitation (ChIP) with anti-methylated histone antibodies and anti-GCN5, quantitative PCR of precipitated chromatin, diet intervention Journal of nutritional science and vitaminology / Nutrition Medium 21697636 25592016

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PloS one 285 24587162
2018 Development of SGLT1 and SGLT2 inhibitors. Diabetologia 272 30132033
2017 Metformin Alters Upper Small Intestinal Microbiota that Impact a Glucose-SGLT1-Sensing Glucoregulatory Pathway. Cell metabolism 209 29056513
1997 Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo. The American journal of physiology 205 9435650
2003 Human cardiomyocytes express high level of Na+/glucose cotransporter 1 (SGLT1). Journal of cellular biochemistry 173 14505350
2004 Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1, SGK3, and PKB. Obesity research 150 15166308
2016 The Na+-D-glucose cotransporters SGLT1 and SGLT2 are targets for the treatment of diabetes and cancer. Pharmacology & therapeutics 119 27773781
2005 SGLT-1-mediated glucose uptake protects intestinal epithelial cells against LPS-induced apoptosis and barrier defects: a novel cellular rescue mechanism? FASEB journal : official publication of the Federation of American Societies for Experimental Biology 117 16260652
1997 Expression of the Na+-D-glucose cotransporter SGLT1 in neurons. Journal of neurochemistry 112 9202297
2021 Angiotensin II-induced upregulation of SGLT1 and 2 contributes to human microparticle-stimulated endothelial senescence and dysfunction: protective effect of gliflozins. Cardiovascular diabetology 110 33726768
1991 Distribution of the SGLT1 Na+/glucose cotransporter and mRNA along the crypt-villus axis of rabbit small intestine. Biochemical and biophysical research communications 109 1764071
2015 Expression of SGLT1 in Human Hearts and Impairment of Cardiac Glucose Uptake by Phlorizin during Ischemia-Reperfusion Injury in Mice. PloS one 92 26121582
2004 The diurnal rhythm of the intestinal transporters SGLT1 and PEPT1 is regulated by the feeding conditions in rats. The Journal of nutrition 88 15333706
2011 Comparative expression of hexose transporters (SGLT1, GLUT1, GLUT2 and GLUT5) throughout the mouse gastrointestinal tract. Histochemistry and cell biology 86 21274556
2010 Expression of Na+/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners. The British journal of nutrition 86 20338074
1994 Structure of the human Na+/glucose cotransporter gene SGLT1. The Journal of biological chemistry 86 8195156
2019 Macula Densa SGLT1-NOS1-Tubuloglomerular Feedback Pathway, a New Mechanism for Glomerular Hyperfiltration during Hyperglycemia. Journal of the American Society of Nephrology : JASN 82 30867247
2016 Intestinal SGLT1 in metabolic health and disease. American journal of physiology. Gastrointestinal and liver physiology 76 27012770
2010 Expression of Na+/glucose co-transporter 1 (SGLT1) in the intestine of piglets weaned to different concentrations of dietary carbohydrate. The British journal of nutrition 75 20385036
1997 Nutrient regulation of human intestinal sugar transporter (SGLT1) expression. Gut 74 9274472
2016 Interaction of the Sodium/Glucose Cotransporter (SGLT) 2 inhibitor Canagliflozin with SGLT1 and SGLT2. The Journal of pharmacology and experimental therapeutics 73 27189972
2008 Expression of SGLT1, Bcl-2 and p53 in primary pancreatic cancer related to survival. Cancer investigation 72 18853313
2018 Genetic Variants in SGLT1, Glucose Tolerance, and Cardiometabolic Risk. Journal of the American College of Cardiology 67 30286918
2001 Isotonic transport by the Na+-glucose cotransporter SGLT1 from humans and rabbit. The Journal of physiology 63 11251046
2002 Vimentin affects localization and activity of sodium-glucose cotransporter SGLT1 in membrane rafts. Journal of cell science 59 11865027
2010 Regulation of Na+-coupled glucose carrier SGLT1 by AMP-activated protein kinase. Molecular membrane biology 57 20334581
2009 Dietary phloridzin reduces blood glucose levels and reverses Sglt1 expression in the small intestine in streptozotocin-induced diabetic mice. Journal of agricultural and food chemistry 57 19413312
2003 More than apical: Distribution of SGLT1 in Caco-2 cells. American journal of physiology. Cell physiology 57 12773314
2015 Transcriptional regulation of NHE3 and SGLT1 by the circadian clock protein Per1 in proximal tubule cells. American journal of physiology. Renal physiology 55 26377793
1993 The expression of the Na+/glucose cotransporter (SGLT1) gene in lamb small intestine during postnatal development. Biochimica et biophysica acta 55 8452856
2000 Glycoside binding and translocation in Na(+)-dependent glucose cotransporters: comparison of SGLT1 and SGLT3. The Journal of membrane biology 54 10926676
2019 Knockout of Na+-glucose cotransporter SGLT1 mitigates diabetes-induced upregulation of nitric oxide synthase NOS1 in the macula densa and glomerular hyperfiltration. American journal of physiology. Renal physiology 53 31091127
1999 Missense mutations in SGLT1 cause glucose-galactose malabsorption by trafficking defects. Biochimica et biophysica acta 53 10036327
2013 Attenuation of glucose transport across Caco-2 cell monolayers by a polyphenol-rich herbal extract: interactions with SGLT1 and GLUT2 transporters. BioFactors (Oxford, England) 47 23361943
2003 Effect of GLP-2 on mucosal morphology and SGLT1 expression in tissue-engineered neointestine. American journal of physiology. Gastrointestinal and liver physiology 45 12919941
1989 Assignment of the human intestinal Na+/glucose cotransporter gene (SGLT1) to the q11.2----qter region of chromosome 22. Genomics 44 2714793
2016 Oat β-glucan depresses SGLT1- and GLUT2-mediated glucose transport in intestinal epithelial cells (IEC-6). Nutrition research (New York, N.Y.) 43 27188900
2013 Absorption of resveratrol by vascular endothelial cells through passive diffusion and an SGLT1-mediated pathway. The Journal of nutritional biochemistry 43 23927891
2011 Multiple sequence variations in SLC5A1 gene are associated with glucose-galactose malabsorption in a large cohort of Old Order Amish. Clinical genetics 43 20486940
2011 Bridging the gap between structure and kinetics of human SGLT1. American journal of physiology. Cell physiology 42 22159082
2023 SGLT1: A Potential Drug Target for Cardiovascular Disease. Drug design, development and therapy 40 37435096
2012 Upregulation of Na-coupled glucose transporter SGLT1 by Tau tubulin kinase 2. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 39 22814243
2011 Coexpression of SGLT1 and EGFR is associated with tumor differentiation in oral squamous cell carcinoma. Odontology 39 21607591
2014 KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state. The Journal of endocrinology 38 24891433
2002 Glucose uptake via SGLT-1 is stimulated by beta(2)-adrenoceptors in the ruminal epithelium of sheep. The Journal of nutrition 38 12042442
2013 EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors. The Prostate 37 23765757
2012 Development of a cell-based nonradioactive glucose uptake assay system for SGLT1 and SGLT2. Analytical biochemistry 37 22796500
2009 Na+-glucose cotransporter SGLT1 protein in salivary glands: potential involvement in the diabetes-induced decrease in salivary flow. The Journal of membrane biology 37 19238474
2022 Deoxynivalenol triggers porcine intestinal tight junction disorder through hijacking SLC5A1 and PGC1α-mediated mitochondrial function. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 36 35307453
2021 The Role of Combined SGLT1/SGLT2 Inhibition in Reducing the Incidence of Stroke and Myocardial Infarction in Patients with Type 2 Diabetes Mellitus. Cardiovascular drugs and therapy 36 34750713
2019 Pretreatment with KGA-2727, a selective SGLT1 inhibitor, is protective against myocardial infarction-induced ventricular remodeling and heart failure in mice. Journal of pharmacological sciences 36 31776072
2016 The Sodium Glucose Cotransporter SGLT1 Is an Extremely Efficient Facilitator of Passive Water Transport. The Journal of biological chemistry 36 26945065
1998 Thyroid hormone regulation of the Na+/glucose cotransporter SGLT1 in Caco-2 cells. The Biochemical journal 35 9729472
1998 High-level expression of Na+/D-glucose cotransporter (SGLT1) in a stably transfected Chinese hamster ovary cell line. Biochimica et biophysica acta 35 9733990
2001 Transcriptional regulation of the ovine intestinal Na+/glucose cotransporter SGLT1 gene. Role of HNF-1 in glucose activation of promoter function. European journal of biochemistry 34 11606209
2017 Lycium barbarum L. Polysaccharide (LBP) Reduces Glucose Uptake via Down-Regulation of SGLT-1 in Caco2 Cell. Molecules (Basel, Switzerland) 33 28241438
2009 Resistin-like molecule-beta inhibits SGLT-1 activity and enhances GLUT2-dependent jejunal glucose transport. Diabetes 33 19502416
2018 Role of SGLT1 in high glucose level-induced MMP-2 expression in human cardiac fibroblasts. Molecular medicine reports 32 29512713
2010 Cadmium down-regulation of kidney Sp1 binding to mouse SGLT1 and SGLT2 gene promoters: possible reaction of cadmium with the zinc finger domain of Sp1. Toxicology and applied pharmacology 32 20060848
2005 Rat renal glucose transporter SGLT1 exhibits zonal distribution and androgen-dependent gender differences. American journal of physiology. Renal physiology 31 16204409
2019 Gene deletion of the Na+-glucose cotransporter SGLT1 ameliorates kidney recovery in a murine model of acute kidney injury induced by ischemia-reperfusion. American journal of physiology. Renal physiology 30 30995111
2019 SGLT1 is required for the survival of triple-negative breast cancer cells via potentiation of EGFR activity. Molecular oncology 30 31199048
2017 Ghrelin Facilitates GLUT2-, SGLT1- and SGLT2-mediated Intestinal Glucose Transport in Goldfish (Carassius auratus). Scientific reports 30 28338019
2002 The effect of epidermal growth factor on the distribution of SGLT-1 in rabbit jejunum. Canadian journal of physiology and pharmacology 30 12430982
2022 Structural mechanism of SGLT1 inhibitors. Nature communications 29 36307403
2021 New insight in understanding the contribution of SGLT1 in cardiac glucose uptake: evidence for a truncated form in mice and humans. American journal of physiology. Heart and circulatory physiology 29 33416451
2000 Expression of the Na+/glucose co-transporter (SGLT1) in the intestine of domestic and wild ruminants. Pflugers Archiv : European journal of physiology 29 11205056
2003 Tissue-engineered neomucosa: morphology, enterocyte dynamics, and SGLT1 expression topography. Transplantation 28 12548119
1997 Na/D-glucose cotransport and SGLT1 expression in hen colon correlates with dietary Na+. Comparative biochemistry and physiology. Part A, Physiology 28 9366048
2011 Stimulation of the glucose carrier SGLT1 by JAK2. Biochemical and biophysical research communications 27 21406183
2011 Jejunal induction of SI and SGLT1 genes in rats by high-starch/low-fat diet is associated with histone acetylation and binding of GCN5 on the genes. Journal of nutritional science and vitaminology 27 21697636
2021 SGLT-1-specific inhibition ameliorates renal failure and alters the gut microbial community in mice with adenine-induced renal failure. Physiological reports 26 34921520
2015 Regulation of intestinal SGLT1 by catestatin in hyperleptinemic type 2 diabetic mice. Laboratory investigation; a journal of technical methods and pathology 26 26552046
2024 SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study. Cardiovascular diabetology 25 38715111
2009 Diurnal expression of the rat intestinal sodium-glucose cotransporter 1 (SGLT1) is independent of local luminal factors. Surgery 25 19231582
2013 Increased SGLT1 expression in salivary gland ductal cells correlates with hyposalivation in diabetic and hypertensive rats. Diabetology & metabolic syndrome 24 24499577
2008 Capsaicin-sensitive vagal afferents modulate posttranscriptional regulation of the rat Na+/glucose cotransporter SGLT1. American journal of physiology. Gastrointestinal and liver physiology 24 18308853
1999 Role of actin in EGF-induced alterations in enterocyte SGLT1 expression. The American journal of physiology 24 9950820
2019 Trilobatin, a Novel SGLT1/2 Inhibitor, Selectively Induces the Proliferation of Human Hepatoblastoma Cells. Molecules (Basel, Switzerland) 23 31540429
2014 Regulation of sodium glucose co-transporter SGLT1 through altered glycosylation in the intestinal epithelial cells. Biochimica et biophysica acta 23 24412219
2008 Role of Sp1 and HNF1 transcription factors in SGLT1 regulation during chronic intestinal inflammation. American journal of physiology. Gastrointestinal and liver physiology 23 18339704
2021 Inhibition of SGLT1 protects against glycemic variability-induced cardiac damage and pyroptosis of cardiomyocytes in diabetic mice. Life sciences 21 33508297
2021 SGLT1 Inhibition Attenuates Apoptosis in Diabetic Cardiomyopathy via the JNK and p38 Pathway. Frontiers in pharmacology 21 33597877
2015 Phosphorylation of RS1 (RSC1A1) Steers Inhibition of Different Exocytotic Pathways for Glucose Transporter SGLT1 and Nucleoside Transporter CNT1, and an RS1-Derived Peptide Inhibits Glucose Absorption. Molecular pharmacology 21 26464324
2003 The age-associated decline in the intestinal uptake of glucose is not accompanied by changes in the mRNA or protein abundance of SGLT1. Mechanisms of ageing and development 21 14659592
2020 HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT1. Biochimica et biophysica acta. Molecular basis of disease 20 32711050
2019 SLC5A1 promotes growth and proliferation of pancreatic carcinoma via glucose-dependent AMPK/mTOR signaling. Cancer management and research 20 31114359
2014 Induction of histone H3K4 methylation at the promoter, enhancer, and transcribed regions of the Si and Sglt1 genes in rat jejunum in response to a high-starch/low-fat diet. Nutrition (Burbank, Los Angeles County, Calif.) 20 25592016
2016 Transmissible Gastroenteritis Virus Infection Enhances SGLT1 and GLUT2 Expression to Increase Glucose Uptake. PloS one 19 27851758
2015 Reduction in SGLT1 mRNA Expression in the Ventromedial Hypothalamus Improves the Counterregulatory Responses to Hypoglycemia in Recurrently Hypoglycemic and Diabetic Rats. Diabetes 19 26130763
2006 Regulation of sodium-glucose cotransporter SGLT1 in the intestine of hypertensive rats. American journal of physiology. Regulatory, integrative and comparative physiology 19 16690767
2023 Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection. Gut microbes 18 37350393
2023 SGLT2 and SGLT1 inhibitors suppress the activities of the RVLM neurons in newborn Wistar rats. Hypertension research : official journal of the Japanese Society of Hypertension 18 37710035
2017 The flavanone homoeriodictyol increases SGLT-1-mediated glucose uptake but decreases serotonin release in differentiated Caco-2 cells. PloS one 18 28192456
2010 Protein kinase C mediated intracellular signaling pathways are involved in the regulation of sodium-dependent glucose co-transporter SGLT1 activity. Journal of cellular biochemistry 18 20069550
1992 The Na+/glucose cotransporter (SGLT1). Acta physiologica Scandinavica. Supplementum 18 1449065
2017 SGLT1-Mediated Transport in Caco-2 Cells Is Highly Dependent on Cell Bank Origin. Journal of pharmaceutical sciences 17 28454747
2016 Inhibition of SGLT1 abrogates preconditioning-induced cardioprotection against ischemia-reperfusion injury. Biochemical and biophysical research communications 17 26920054
2021 PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs. Oncogene 16 34155348
2012 PER1 modulates SGLT1 transcription in vitro independent of E-box status. Digestive diseases and sciences 16 22526585