Affinage

SLC41A1

Solute carrier family 41 member 1 · UniProt Q8IVJ1

Length
513 aa
Mass
54.9 kDa
Annotated
2026-06-10
49 papers in source corpus 16 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC41A1 is the predominant cellular Mg2+ efflux carrier, a plasma membrane transporter that extrudes intracellular Mg2+ and thereby sets cytosolic Mg2+ levels that gate multiple downstream signaling cascades (PMID:18367447, PMID:22031603). It was first established as a bona fide Mg2+ carrier by functional complementation of a Salmonella strain lacking all endogenous Mg2+ transport systems and by direct Mg2+ efflux measurements in HEK293 cells (PMID:18367447); in oocytes the transporter mediates saturable, voltage-dependent divalent cation uptake with broad ion selectivity (Mg2+, Sr2+, Zn2+, Fe2+, Co2+ and others) (PMID:15713785). The protein adopts a MgtE-like topology with intracellular N- and C-termini and a ~10-transmembrane-helix architecture, and an intact ion-conducting pore is required for transport, since pore mutations (p.Asp262Ala) abolish Mg2+ extrusion (PMID:21696366, PMID:24491491, PMID:30417250). SLC41A1 functions as a Na+/Mg2+ exchanger driving Na+-dependent efflux that is blocked by imipramine and quinidine, though Na+-independent extrusion is also observed under isotopic transport conditions (PMID:22031603, PMID:30417250). Its activity is dynamically regulated: PKA phosphorylation, insulin/ISP signaling, and p38 MAPK modulate efflux capacity, and extracellular Mg2+ controls surface expression through an N-terminal cytoplasmic domain-dependent endosomal recycling and lysosomal degradation pathway (PMID:22031603, PMID:21696366, PMID:26355001). Endogenous SLC41A1 localizes to renal tubules at the corticomedullary boundary and to the basolateral membrane of polarized epithelial cells (PMID:23661805, PMID:30417250). By controlling cytosolic Mg2+, SLC41A1 acts upstream of Ca2+-NFATc4 fibrogenic signaling in cardiac fibroblasts (PMID:25263961), Wnt/β-catenin signaling during osteogenic differentiation (PMID:28222767), Akt/Erk pro-survival signaling (PMID:29435164), and an LPS/STAT5A-driven mitochondrial-permeability-transition/AIM2-inflammasome pyroptosis axis (PMID:40831212). A homozygous exon-6 skipping mutation deleting a transmembrane helix abolishes transport and is associated with renal disease, with zebrafish slc41a1 knockdown producing nephronophthisis-like cystic kidney phenotypes (PMID:23661805); Parkinson-disease-associated variants directly alter activity (p.A350V gain-of-function with disrupted PKA regulation; p.R244H loss-of-function) (PMID:23976986, PMID:24661466). Despite these roles, SLC41A1 knockout mice maintain normal serum and urine Mg2+ under normal and low-Mg2+ diets and do not compensate for SLC41A3 loss, indicating it is dispensable for systemic Mg2+ homeostasis in mice (PMID:36049064).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2005 High

    Establishing whether SLC41A1 is itself a Mg2+ transporter: heterologous expression revealed it mediates divalent-cation flux, providing the first direct functional identity.

    Evidence Two-electrode voltage-clamp of cloned mouse SLC41A1 in Xenopus oocytes with ionic substitution and saturation kinetics

    PMID:15713785

    Open questions at the time
    • Uptake direction in oocytes appeared Na+/Cl- independent, leaving the physiological transport mode (uptake vs efflux) unresolved
    • Broad divalent selectivity raised question of in vivo substrate specificity
  2. 2008 High

    Confirming SLC41A1 as a genuine Mg2+ carrier and defining its cellular action: it localizes to the plasma membrane and mediates Mg2+ efflux, reconciling earlier ambiguity about transport direction.

    Evidence Genetic complementation in Mg2+-transport-deficient Salmonella, whole-cell patch clamp, mag-fura-2 Mg2+ assay, and fractionation in HEK293

    PMID:18367447

    Open questions at the time
    • Coupling ion and exchange stoichiometry not yet defined
    • Nature of high-molecular-mass complexes not characterized
  3. 2011 High

    Defining the transport mechanism and its regulation: SLC41A1 was identified as a Na+/Mg2+ exchanger whose activity is controlled by PKA phosphorylation and post-transcriptionally by extracellular Mg2+ via N-terminal-dependent endosomal recycling.

    Evidence Mag-fura-2 efflux with Na+ substitution and exchanger inhibitors; structure-function truncation mutants, surface-expression assays, and TRPM7-deficient cell complementation

    PMID:21696366 PMID:22031603

    Open questions at the time
    • PKA phosphorylation site(s) not mapped
    • Endosomal recycling machinery and adaptor proteins unidentified
  4. 2013 High

    Linking SLC41A1 transport to disease and tissue context: a loss-of-function exon-6 deletion abolishes transport and a gain-of-function PD variant enhances efflux while uncoupling PKA regulation, connecting transport activity to renal and neurological phenotypes.

    Evidence WT vs mutant transport assays in HEK293, human kidney immunolocalization, zebrafish morpholino knockdown, and split-ubiquitin topology mapping

    PMID:23661805 PMID:23976986 PMID:24491491

    Open questions at the time
    • Mechanistic basis for A350V PKA insensitivity unresolved
    • Zebrafish cystic-kidney phenotype not mechanistically tied to Mg2+ transport at the time
  5. 2014 Medium

    Placing SLC41A1 within physiological signaling: its Mg2+ efflux sits upstream of Ca2+-NFATc4 fibrogenic signaling, and a R244H PD variant is loss-of-function despite normal membrane targeting.

    Evidence siRNA knockdown in cardiac fibroblasts with Mg2+/Ca2+ measurements and fibrosis-marker readouts; variant transport and WGA co-localization in HEK293

    PMID:24661466 PMID:25263961

    Open questions at the time
    • Molecular link between Mg2+ efflux and Ca2+ rise not defined
    • R244H loss-of-function mechanism (folding vs pore) not established
  6. 2015 Medium

    Mapping hormonal and kinase control of efflux: insulin/ISP signaling inhibits while p38 MAPK activates SLC41A1, refining the regulatory network beyond PKA.

    Evidence Mag-fura-2 efflux assays in HEK293 with ISP and p38 MAPK pharmacological inhibitors and forskolin

    PMID:26355001

    Open questions at the time
    • Direct phosphorylation by p38 vs indirect effect not distinguished
    • Physiological relevance of insulin regulation in native tissue untested
  7. 2017 Medium

    Extending the signaling reach of Mg2+ efflux: SLC41A1 modulates Wnt/β-catenin osteogenic signaling and dampens Akt/Erk pro-survival signaling, establishing it as a broad signaling node.

    Evidence siRNA knockdown in MSCs with mineralization and signaling readouts; overexpression with DMR, antibody arrays and phospho-Western across three cell lines

    PMID:28222767 PMID:29435164

    Open questions at the time
    • Whether signaling effects are solely Mg2+-dependent vs transport-independent not fully separated
    • In vivo relevance of osteogenic and survival roles untested
  8. 2018 High

    Resolving the pore and polarity: a pore-dead mutant fails to transport and fails to rescue zebrafish Mg2+ wasting, confirming transport requires an intact pore and that SLC41A1 acts at the basolateral membrane, with isotopic data showing Na+-independent extrusion.

    Evidence 25Mg2+ isotope transport in HEK293, pore mutant (p.Asp262Ala) rescue in zebrafish morphants, MDCK localization

    PMID:30417250

    Open questions at the time
    • Apparent contradiction between Na+-dependent and Na+-independent efflux modes unresolved
    • Structural model of the conducting pore not determined
  9. 2022 High

    Testing systemic necessity in vivo: knockout mice retain normal Mg2+ balance and do not compensate for SLC41A3 loss, showing SLC41A1 is dispensable for whole-body Mg2+ homeostasis despite robust in vitro transport.

    Evidence Single and SLC41A1/SLC41A3 double-knockout mice with dietary Mg2+ challenge and transporter expression profiling

    PMID:36049064

    Open questions at the time
    • Tissue-specific or stress-condition roles not excluded
    • Reconciliation with human disease variants not addressed
  10. 2025 Medium

    Connecting transcriptional control to a cell-death program: LPS-driven STAT5A upregulates SLC41A1, and the resulting Mg2+ depletion triggers mitochondrial-permeability-transition-driven AIM2 inflammasome activation and pyroptosis.

    Evidence STAT5A ChIP/promoter binding, SLC41A1 siRNA, mPTP and mtDNA/ROS assays, AIM2/GSDMD readouts and Mg2+ rescue in dental pulp stem cells

    PMID:40831212

    Open questions at the time
    • Not independently replicated
    • Generalizability beyond dental pulp stem cells unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how SLC41A1 can be a robust Mg2+ efflux carrier and signaling node in vitro yet dispensable for systemic Mg2+ homeostasis in mice, and which physiological or pathological contexts require its activity.
  • No high-resolution structure of the transporter pore
  • Definitive coupling ion and stoichiometry under physiological conditions unresolved
  • Tissue context in which SLC41A1 is non-redundant unidentified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 4 GO:0140104 molecular carrier activity 3
Localization
GO:0005886 plasma membrane 4
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-382551 Transport of small molecules 3

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 Mouse SLC41A1 expressed in Xenopus laevis oocytes mediates saturable, rheogenic, voltage-dependent Mg2+ uptake (Km ~0.67 mM) that is not coupled to Na+ or Cl-, and also transports Sr2+, Zn2+, Cu2+, Fe2+, Co2+, Ba2+, and Cd2+; La3+ abolishes uptake. The transcript is upregulated in kidney with Mg2+ deficiency. Two-electrode voltage-clamp in Xenopus oocytes expressing cloned mouse SLC41A1 Physiological genomics High 15713785
2008 Human SLC41A1 overexpressed in HEK293 cells localizes to the plasma membrane, forms high-molecular-mass protein complexes, mediates Mg2+ efflux (reducing free and total intracellular Mg2+), is temperature-sensitive, and is insensitive to cobalt(III) hexaammine. It functionally complements a Salmonella enterica strain lacking all three endogenous Mg2+ transport systems (CorA, MgtA, MgtB), confirming it as a bona fide Mg2+ carrier. Genetic complementation in Mg2+-transport-deficient Salmonella; whole-cell patch clamp in HEK293; intracellular Mg2+ measurements (mag-fura-2 fluorescence); subcellular fractionation/Western blot The Journal of biological chemistry High 18367447
2011 Human SLC41A1 overexpressed in HEK293 cells mediates Na+-dependent Mg2+ efflux; a 3–9-fold elevation of intracellular Mg2+ drives 5–9-fold increased efflux strictly dependent on extracellular Na+ (91% abolished by N-methyl-D-glucamine replacement). Known Na+/Mg2+ exchanger inhibitors imipramine and quinidine inhibited efflux by 88–100%. Transport activity is regulated by cAMP-dependent protein kinase A (PKA) phosphorylation. Fluorescent Mg2+ probe (mag-fura-2) in SLC41A1-overexpressing HEK293 cells; ionic substitution; pharmacological inhibition; PKA stimulation American journal of physiology. Cell physiology High 22031603
2011 SLC41A1 Mg2+ transport function is regulated post-transcriptionally by extracellular Mg2+ via an N-terminal cytoplasmic domain-dependent endosomal recycling mechanism. The N-terminal domain is required for Mg2+-dependent regulation of lysosomal degradation and plasma membrane surface expression. SLC41A1 adopts the same plasma membrane topology as bacterial MgtE, and an intact Mg2+-transporting pore is required to complement growth of TRPM7-deficient cells. Structure-function analysis with truncation/domain mutants; complementation of TRPM7-deficient DT40 B-cells; subcellular localization studies; surface expression assays The Biochemical journal High 21696366
2013 A homozygous splice-acceptor mutation (c.698G>T) in SLC41A1 causing in-frame skipping of exon 6 (deletion of a transmembrane helix) completely abolishes the protein's Mg2+ transport function. In normal human kidney, endogenous SLC41A1 localizes specifically to renal tubules at the corticomedullary boundary. Morpholino knockdown of slc41a1 in zebrafish produces ventral body curvature, hydrocephalus, and cystic kidneys similar to nephronophthisis (NPHP) gene knockdowns. Transfection of WT vs. exon-6-deleted mutant SLC41A1 with functional transport assay; immunolocalization in human kidney tissue; morpholino knockdown in zebrafish Journal of the American Society of Nephrology : JASN High 23661805
2013 The PD-associated substitution p.A350V in SLC41A1 is a gain-of-function mutation that enhances Na+-dependent Mg2+ efflux by ~69% compared to wild-type. This enhanced efflux capacity is accompanied by insensitivity of the mutant to cAMP/PKA stimulation, indicating disrupted hormonal regulation, and results in reduced cell proliferation. Fluorescent Mg2+ efflux assay (mag-fura-2) in HEK293 cells expressing WT or p.A350V SLC41A1; PKA stimulation; proliferation assay PloS one Medium 23976986
2013 SLC41A1 membrane topology was experimentally determined to have both N- and C-termini oriented intracellularly, consistent with a 10 transmembrane helix model, using split-ubiquitin yeast two-hybrid assays with orientation-specific membrane marker co-expression. Split-ubiquitin functional assay in S. cerevisiae with C- or N-terminally tagged SLC41A1 fused to Cub-LexA-VP16 reporter, co-expressed with NubI-tagged orientation markers Magnesium research Medium 24491491
2013 Using split-ubiquitin yeast two-hybrid screening, putative binding partners of SLC41A1 were identified, including 3-beta-hydroxysteroid-Δ8,Δ7-isomerase, BAP31 (BCAP31), IER3IP1, PPIB, and others mostly localized to the ER, suggesting they contribute to SLC41A1 maturation, folding, and anterograde transport. Co-purification with strep-tagged SLC41A1 identified ACCA1, UBB, ATX2L, HSP7C, and TBB as co-purifying proteins. Split-ubiquitin yeast two-hybrid assay; co-purification with strep-tagged SLC41A1 followed by mass spectrometry Magnesium research Low 23823179
2014 SLC41A1 knockdown by siRNA in cardiac fibroblasts attenuates angiotensin II-induced Mg2+ efflux, prevents the associated rise in intracellular Ca2+, reduces NFATc4 nuclear translocation, and suppresses upregulation of fibrosis markers (CTGF, fibronectin, α-SMA), identifying SLC41A1-mediated Mg2+ extrusion as upstream of Ca2+-NFATc4 fibrogenic signaling. siRNA knockdown of SLC41A1 in cardiac fibroblasts; intracellular Mg2+ and Ca2+ measurements; Western blot for fibrosis markers; NFATc4 nuclear translocation assay Archives of biochemistry and biophysics Medium 25263961
2014 The R244H variant of SLC41A1, identified in an early-onset PD patient, produces a loss-of-function in Mg2+ efflux when expressed in HEK293 cells, while the protein still co-localizes to plasma membrane regions (wheat germ agglutinin-positive areas) similar to wild-type. Stable expression of WT vs. R244H SLC41A1 in HEK293 cells; mag-fluo-4 fluorescent Mg2+ efflux assay; immunofluorescence co-localization with WGA Parkinsonism & related disorders Medium 24661466
2015 Insulin inhibits SLC41A1-mediated Mg2+ efflux by up to ~51% via the insulin-signaling pathway (ISP); this inhibition is reversed by ISP inhibitors wortmannin or zardaverine. Insulin also triggers early Mg2+ release from intracellular stores. Additionally, p38 MAPK independently activates SLC41A1-mediated Mg2+ efflux, as its inhibitor (SB202190) reduces efflux ~49% in the absence of insulin. Fluorescent Mg2+ efflux assay (mag-fura-2) in SLC41A1-overexpressing HEK293 cells with pharmacological inhibitors of ISP and p38 MAPK; adenylate cyclase activator (forskolin) co-treatment The Journal of nutrition Medium 26355001
2017 SLC41A1 knockdown in mesenchymal stromal cells during osteogenesis accelerates mineralization, attenuates high-Mg2+-induced mineralization inhibition, reduces Dkk1 expression, promotes nuclear translocation of phosphorylated β-catenin, and elevates secreted MGP, placing SLC41A1-mediated Mg2+ efflux as a regulator of Wnt/β-catenin signaling during osteogenic differentiation. siRNA knockdown of Slc41a1 in murine and human MSCs; Alizarin Red mineralization staining; RT-qPCR for osteogenic markers; immunofluorescence for phospho-β-catenin nuclear translocation Stem cell research & therapy Medium 28222767
2017 Overexpression of SLC41A1 in HEK293, SH-SY5Y, and HeLa cells significantly reduces phosphorylation of Akt/PKB (Thr308 and/or Ser473) and Erk1/2 (Thr202/Tyr204), attenuating pro-survival signaling. This correlates with decreased intracellular Mg2+ caused by enhanced SLC41A1-mediated Mg2+ efflux. Dynamic mass redistribution assay; PathScan RTK signaling antibody array; confirmatory Western blot for phospho-Akt and phospho-Erk1/2; mag-fura-2 intracellular Mg2+ measurement in multiple cell lines Oncotarget Medium 29435164
2018 In polarized MDCK cells, SLC41A1 localizes to the basolateral membrane. A pore mutation (p.Asp262Ala) abolishes SLC41A1-mediated Mg2+ extrusion in HEK293 cells and fails to rescue Mg2+ wasting in slc41a1-morphant zebrafish, while WT mouse SLC41A1 rescues the zebrafish phenotype. 25Mg2+ transport assays indicate SLC41A1 mediates Mg2+ extrusion independently of Na+. 25Mg2+ isotope transport assay in HEK293 cells; pore-dead mutant (p.Asp262Ala) rescue experiment in zebrafish morphants; immunofluorescence localization in MDCK cells Pflugers Archiv : European journal of physiology High 30417250
2022 SLC41A1 knockout mice display normal serum and urine Mg2+ levels under normal and low-Mg2+ dietary conditions, and Mg2+ transporter gene expression (Trpm6, Trpm7, Cnnm2, Slc41a3) is unchanged by genotype. Double knockout of SLC41A1 and SLC41A3 shows the same serum Mg2+ phenotype as SLC41A3 single knockout, demonstrating that SLC41A1 does not compensate for SLC41A3 loss and is not required for systemic Mg2+ homeostasis in mice. SLC41A1 knockout and SLC41A1/SLC41A3 double-knockout mouse models; serum and urine Mg2+ measurements; dietary Mg2+ restriction challenge; RT-qPCR for Mg2+ transporter genes American journal of physiology. Renal physiology High 36049064
2025 LPS activates STAT5A, which binds to the SLC41A1 promoter and upregulates SLC41A1 expression, driving Mg2+ efflux from dental pulp stem cells (DPSCs). This Mg2+ depletion destabilizes the mitochondrial permeability transition pore (mPTP) via OSCP–CypD interaction, releasing ROS and mtDNA, activating the AIM2 inflammasome, and inducing GSDMD-mediated pyroptosis. Exogenous Mg2+ supplementation rescues DPSC viability. STAT5A ChIP/promoter binding assay; SLC41A1 siRNA knockdown; intracellular Mg2+ measurement; mPTP opening assay; mtDNA/ROS quantification; AIM2/GSDMD inflammasome readouts; rescue with exogenous Mg2+ Advanced science Medium 40831212

Source papers

Stage 0 corpus · 49 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 Human gene SLC41A1 encodes for the Na+/Mg²+ exchanger. American journal of physiology. Cell physiology 116 22031603
2005 Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters. Physiological genomics 103 15713785
2008 SLC41A1 is a novel mammalian Mg2+ carrier. The Journal of biological chemistry 102 18367447
1995 Cloning and characterization of MgtE, a putative new class of Mg2+ transporter from Bacillus firmus OF4. Journal of bacteriology 94 7868596
2003 The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. Biochemical and biophysical research communications 73 12810078
2013 Substitution p.A350V in Na⁺/Mg²⁺ exchanger SLC41A1, potentially associated with Parkinson's disease, is a gain-of-function mutation. PloS one 63 23976986
1995 Cloning of the mgtE Mg2+ transporter from Providencia stuartii and the distribution of mgtE in gram-negative and gram-positive bacteria. Journal of bacteriology 60 7665526
2013 Mutation of the Mg2+ transporter SLC41A1 results in a nephronophthisis-like phenotype. Journal of the American Society of Nephrology : JASN 57 23661805
2013 The SLC41 family of MgtE-like magnesium transporters. Molecular aspects of medicine 46 23506895
2011 SLC41A1 Mg(2+) transport is regulated via Mg(2+)-dependent endosomal recycling through its N-terminal cytoplasmic domain. The Biochemical journal 44 21696366
2018 SLC41A1 is essential for magnesium homeostasis in vivo. Pflugers Archiv : European journal of physiology 34 30417250
2001 The MgtE Mg2+ transport protein is involved in Aeromonas hydrophila adherence. FEMS microbiology letters 34 11430413
2009 The Pseudomonas aeruginosa magnesium transporter MgtE inhibits transcription of the type III secretion system. Infection and immunity 33 20028803
2017 Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells. Stem cell research & therapy 31 28222767
2011 Genetic variants in the RAB7L1 and SLC41A1 genes of the PARK16 locus in Chinese Parkinson's disease patients. The International journal of neuroscience 27 21812739
2015 Insulin Modulates the Na+/Mg2+ Exchanger SLC41A1 and Influences Mg2+ Efflux from Intracellular Stores in Transgenic HEK293 Cells. The Journal of nutrition 24 26355001
2013 Identification and proximal tubular localization of the Mg²⁺ transporter, Slc41a1, in a seawater fish. American journal of physiology. Regulatory, integrative and comparative physiology 22 23761638
2013 SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women. Hypertension in pregnancy 20 23844728
2014 Variant R244H in Na+/Mg2+ exchanger SLC41A1 in Taiwanese Parkinson's disease is associated with loss of Mg2+ efflux function. Parkinsonism & related disorders 18 24661466
2017 Overexpression of Na+/Mg2+ exchanger SLC41A1 attenuates pro-survival signaling. Oncotarget 17 29435164
2020 Gating-related Structural Dynamics of the MgtE Magnesium Channel in Membrane-Mimetics Utilizing Site-Directed Tryptophan Fluorescence. Journal of molecular biology 15 33203509
2016 Genetic Analysis of the ZNF512B, SLC41A1, and ALDH2 Polymorphisms in Parkinson's Disease in the Iranian Population. Genetic testing and molecular biomarkers 14 27612022
2015 Genetic analysis of SLC41A1 in Chinese Parkinson's disease patients. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 14 26308152
2022 Alzheimer's Disease-Associated SNP rs708727 in SLC41A1 May Increase Risk for Parkinson's Disease: Report from Enlarged Slovak Study. International journal of molecular sciences 13 35163527
2014 MgtE is a dual-function protein in Pseudomonas aeruginosa. Microbiology (Reading, England) 13 24722909
2013 Antibiotic treatment of Pseudomonas aeruginosa biofilms stimulates expression of the magnesium transporter gene mgtE. Microbiology (Reading, England) 13 24162608
2016 SLC41A1 and TRPM7 in magnesium homeostasis and genetic risk for Parkinson's disease. Journal of neurology & neuromedicine 12 31187092
2014 SLC41A1 knockdown inhibits angiotensin II-induced cardiac fibrosis by preventing Mg(2+) efflux and Ca(2+) signaling in cardiac fibroblasts. Archives of biochemistry and biophysics 11 25263961
2018 Expression of magnesium transporter SLC41A1 in the striatum of 6-hydroxydopamine-induced parkinsonian rats. Brain research bulletin 10 30172737
2017 Identification of the putative goldfish (Carassius auratus) magnesium transporter SLC41a1 and functional regulation in the gill, kidney, and intestine in response to dietary and environmental manipulations. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 10 28130070
2022 SLC41A1 knockout mice display normal magnesium homeostasis. American journal of physiology. Renal physiology 9 36049064
2019 A Magnesium Transport Protein Related to Mammalian SLC41 and Bacterial MgtE Contributes to Circadian Timekeeping in a Unicellular Green Alga. Genes 9 30791470
2017 Effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1 in individuals newly diagnosed of pre-hypertension. A randomized, double-blind, placebo-controlled trial. Magnesium research 9 29256407
2019 SNPs rs11240569, rs708727, and rs823156 in SLC41A1 Do Not Discriminate Between Slovak Patients with Idiopathic Parkinson's Disease and Healthy Controls: Statistics and Machine-Learning Evidence. International journal of molecular sciences 8 31546642
2013 Nature of SLC41A1 complexes: report on the split-ubiquitin yeast two hybrid assay. Magnesium research 8 23823179
2012 The B. subtilis MgtE magnesium transporter can functionally compensate TRPM7-deficiency in vertebrate B-cells. PloS one 8 22970223
2023 Characterization of a novel MgtE homolog and its structural dynamics in membrane mimetics. Biophysical journal 7 38042987
2020 Dietary Mg2+ Intake and the Na+/Mg2+ Exchanger SLC41A1 Influence Components of Mitochondrial Energetics in Murine Cardiomyocytes. International journal of molecular sciences 7 33153064
2013 "Inside-in" or "inside-out"? The membrane topology of SLC41A1. Magnesium research 7 24491491
2022 Ion selectivity mechanism of the MgtE channel for Mg2+ over Ca2. iScience 6 36465111
2025 LPS-Induced Mitochondrial Damage via SLC41A1-Mediated Magnesium Ion Efflux Leads to the Pyroptosis of Dental Stem Cells. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 5 40831212
2014 SLC41A1, a Na+/Mg2+ exchanger, is downregulated during exercise. Biomedical reports 5 24944816
2007 Crystallization and preliminary X-ray diffraction analysis of the full-length Mg2+ transporter MgtE. Acta crystallographica. Section F, Structural biology and crystallization communications 5 17671367
2024 The genes mgtE and spoVG are involved in zinc tolerance of Staphylococcus aureus. Applied and environmental microbiology 4 38752746
2007 Crystallization and preliminary X-ray diffraction analysis of the cytosolic domain of the Mg2+ transporter MgtE. Acta crystallographica. Section F, Structural biology and crystallization communications 4 17671366
2024 SLC41A1 overexpression correlates with immune cell infiltration in HCC and promotes its malignant progression. International journal of medical sciences 3 39628683
2026 Magnesium Transporter SLC41A1 Links Magnesium Homeostasis to NMDA Receptor-Related Synaptic Dysfunction: A Transdiagnostic Therapeutic Target for Neuropsychiatric Disorders. Biomedicines 0 41898257
2024 IL-6 Does Not Influence the Expression of SLC41A1 and Other Mg-Homeostatic Factors. International journal of molecular sciences 0 39769039
2012 Backbone resonance assignments for the cytoplasmic region of the Mg(2+) transporter MgtE in the Mg (2+)-unbound state. Biomolecular NMR assignments 0 22477092

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