Affinage

SLC39A1

Zinc transporter ZIP1 · UniProt Q9NY26

Length
324 aa
Mass
34.2 kDa
Annotated
2026-06-10
52 papers in source corpus 17 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC39A1 (ZIP1) is a plasma membrane zinc uptake transporter that mediates saturable, inhibitable Zn2+ influx and serves as a major route for cellular zinc accumulation across diverse cell types (PMID:11301334, PMID:12888280, PMID:25089007). Its transport is competitively inhibited by Fe2+ and Ni2+ and exhibits micromolar affinity for Zn2+ (PMID:25089007), and its surface abundance is controlled by a di-leucine sorting signal (LL148-149) that drives endocytosis and lysosomal degradation (PMID:17635580). At the organismal level, ZIP1 acts redundantly with ZIP2/ZIP3 in zinc redistribution and retention rather than primary dietary acquisition, becoming essential only under dietary zinc deficiency (PMID:16652366, PMID:18353881). Beyond bulk transport, ZIP1 has a dedicated mitochondrial function: it interacts with DRP1 and the mitochondrial calcium uniporter (MCU) to deliver focal Zn2+ entry at fission sites, locally collapsing mitochondrial membrane potential and licensing mitophagic selection of damaged mitochondria (PMID:30581142, PMID:40462487). In alveolar type II cells, ZIP1-imported zinc directly binds and activates the TFEB/TFE3/MITF transcription factors to drive a protective autophagy program that clears damaged mitochondria, placing SLC39A1 upstream of LC3B-dependent autophagy (PMID:42045244). Through these activities ZIP1 modulates cell-type-specific programs including osteogenic differentiation and osteoclast resorption (PMID:16203195, PMID:16005272), GPCR-coupled platelet activation and thrombosis (PMID:37359521), and zinc-dependent oncogenic signaling such as Src/FAK-driven invasion (PMID:42208832).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2001 High

    Established that ZIP1 is a functional plasma membrane zinc uptake transporter rather than an inferred family member, defining its core molecular activity.

    Evidence 65Zn uptake with reciprocal overexpression and antisense knockdown in K562 cells plus membrane localization

    PMID:11301334

    Open questions at the time
    • No structural basis for transport
    • Substrate selectivity not yet kinetically characterized
    • Transport stoichiometry/energetics undefined
  2. 2003 High

    Showed ZIP1 sets zinc accumulation capacity in prostate cells via Vmax modulation and that citrate-chelated, but not EDTA-chelated, zinc is accessible to the transporter.

    Evidence 65Zn uptake kinetics with overexpression/antisense knockdown in PC-3 cells

    PMID:12888280

    Open questions at the time
    • Mechanism of zinc delivery from citrate complexes unresolved
    • No identification of regulatory inputs controlling Vmax
  3. 2006 High

    Defined the in vivo physiological role of ZIP1 as conditional, required for adaptation to zinc deficiency together with ZIP3 rather than for baseline zinc acquisition.

    Evidence ZIP1 and ZIP1/ZIP3 double-knockout mice with embryonic phenotype and 67Zn accumulation under zinc-deficient diet

    PMID:16652366

    Open questions at the time
    • Tissue-specific contributions not dissected
    • Redundancy mechanism with other ZIPs unexplained
  4. 2007 High

    Identified how ZIP1 surface levels are post-translationally regulated, mapping a di-leucine motif sufficient and necessary for endocytic internalization.

    Evidence Site-directed mutagenesis, immunofluorescence, and IL-2 receptor chimera sufficiency assay

    PMID:17635580

    Open questions at the time
    • Adaptor proteins recognizing the motif not identified
    • Signals triggering regulated endocytosis unknown
  5. 2008 High

    Extended the genetic model to show ZIP1-3 act non-compensatorily in zinc homeostasis under deficiency, refining the conditional-essentiality concept.

    Evidence Triple-knockout mice with 67Zn accumulation and embryonic readouts

    PMID:18353881

    Open questions at the time
    • Individual transporter contributions still confounded
    • Molecular basis of non-compensation unresolved
  6. 2014 Medium

    Provided quantitative transport parameters and ion selectivity, distinguishing competitive from non-competitive inhibitors of ZIP1.

    Evidence 65Zn kinetic and cation-competition assays in HEK293T cells expressing mZIP1

    PMID:25089007

    Open questions at the time
    • Whether Fe2+/Ni2+ are themselves transported is untested
    • No structural explanation for selectivity
  7. 2011 Medium

    Demonstrated a pathophysiological consequence of ZIP1-mediated zinc entry, linking it to neuronal Zn2+ accumulation and excitotoxic neurodegeneration.

    Evidence ZIP1/ZIP3 double-knockout mice with intracellular Zn imaging and kainic acid seizure model

    PMID:21209194

    Open questions at the time
    • Relative ZIP1 vs ZIP3 contribution not separated
    • Downstream zinc toxicity mechanism not defined
  8. 2016 Medium

    Showed ZIP1 expression and zinc-clearance activity are inducible by oxidative stress, indicating a stress-responsive regulatory dimension.

    Evidence 65Zn uptake, Western blot, and membrane fractionation in H2O2-treated astrocytes

    PMID:26979775

    Open questions at the time
    • Transcriptional/post-translational mechanism of upregulation unknown
    • Single cell type
  9. 2018 High

    Uncovered a mitochondrial role beyond bulk import: ZIP1 partners with DRP1 and MCU to deliver focal Zn2+ that depolarizes mitochondria at fission sites and triggers mitophagy.

    Evidence Co-IP, live MMP imaging, interaction-disruption experiments, and mitophagy assays

    PMID:30581142

    Open questions at the time
    • Structural basis of the ZIP1-MCU-DRP1 complex unknown
    • How ZIP1 is recruited to mitochondria unresolved
  10. 2005 Medium

    Connected ZIP1 zinc transport to skeletal cell fate, promoting osteogenic differentiation and, when overexpressed, suppressing osteoclast resorption and NF-kB activity.

    Evidence Adenoviral overexpression/siRNA with differentiation, resorption, and EMSA readouts in MSCs and osteoclasts

    PMID:16005272 PMID:16203195

    Open questions at the time
    • Endogenous requirement not tested by knockout in bone
    • Link between zinc flux and Runx2/NF-kB indirect
  11. 2022 Medium

    Implicated ZIP1 in the tumor microenvironment, showing ZIP1+ fibroblasts serve as zinc reservoirs that transfer Zn2+ to cancer cells via connexin-43 to confer chemoresistance.

    Evidence scRNA-seq, gap junction and Zn2+ transfer assays, connexin-43 regulation, ABCB1 efflux in co-culture

    PMID:36207295

    Open questions at the time
    • Direct ZIP1 transport contribution to transferred zinc not isolated
    • Mechanism linking ZIP1 to connexin-43 unknown
  12. 2023 Medium

    Defined a platelet-specific role, showing ZIP1/ZIP3 loss raises free Zn2+ and selectively amplifies GPCR-coupled activation and thrombus formation.

    Evidence ZIP1/ZIP3 knockout mice with ICP-MS/FluoZin3, aggregation, flow-chamber and intravital thrombosis, signaling analysis

    PMID:37359521

    Open questions at the time
    • ZIP1-specific contribution vs ZIP3 not separated
    • Why ITAM signaling is spared unexplained
  13. 2025 Medium

    Confirmed and extended the ZIP1-DRP1 axis in cancer, showing the interaction drives mitochondrial fission and depolarization and that disrupting it suppresses tumor progression.

    Evidence Co-IP, docking, DRP1 inhibition/overexpression rescue, MMP/morphology assays, liver-specific knockout mice in HCC

    PMID:40462487

    Open questions at the time
    • Whether zinc flux per se mediates fission not fully isolated
    • Therapeutic peptide specificity not validated broadly
  14. 2026 High

    Placed ZIP1 atop a protective zinc-autophagy pathway, showing imported zinc directly activates TFEB/TFE3/MITF to drive autophagy and that SLC39A1 acts upstream of LC3B in vivo.

    Evidence AT2-specific conditional knockout/overexpression, zinc chelation/supplementation, TFEB/TFE3/MITF binding assays, and Slc39a1/shLc3b epistasis in lung injury

    PMID:42045244

    Open questions at the time
    • Stoichiometry/mechanism of direct zinc binding to TF not structurally defined
    • Generality beyond AT2 cells untested
  15. 2026 Medium

    Linked ZIP1 zinc import to oncogenic signaling, showing it activates Src/FAK to promote pancreatic cancer migration, invasion, and metastasis.

    Evidence Reciprocal KD/OE with invasion/scratch/spheroid assays, Src/FAK phospho-blots, zinc chelation, and in vivo liver metastasis model

    PMID:42208832

    Open questions at the time
    • How zinc activates Src/FAK mechanistically unknown
    • Single cancer context

Open questions

Synthesis pass · forward-looking unresolved questions
  • How ZIP1 toggles between plasma-membrane bulk zinc import and targeted mitochondrial zinc delivery, and the structural basis of its transport selectivity and complex assembly, remain unresolved.
  • No high-resolution structure of ZIP1 or its mitochondrial complex
  • Trafficking signals routing ZIP1 to mitochondria vs plasma membrane unknown
  • Regulatory logic selecting between physiological roles undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 3
Localization
GO:0005886 plasma membrane 5 GO:0005739 mitochondrion 2
Pathway
R-HSA-382551 Transport of small molecules 3 R-HSA-1430728 Metabolism 2 R-HSA-9612973 Autophagy 2
Partners
DRP1MCU
Complex memberships
ZIP1-MCU-DRP1 mitochondrial complex

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 Human ZIP1 (SLC39A1) is a plasma membrane zinc uptake transporter. Overexpression in K562 erythroleukemia cells increased zinc influx (65Zn uptake), and antisense oligonucleotide knockdown of hZIP1 markedly decreased endogenous zinc uptake activity, establishing ZIP1 as the major zinc transporter in these cells. 65Zn uptake assay in cells overexpressing hZIP1; antisense oligonucleotide knockdown; plasma membrane localization confirmed by subcellular fractionation/immunofluorescence The Journal of biological chemistry High 11301334
2003 In prostate PC-3 cells, ZIP1 overexpression increased zinc uptake Vmax without changing Km, and antisense-mediated knockdown decreased zinc uptake, confirming ZIP1 as a major zinc uptake transporter for zinc accumulation in prostate cells. Zinc uptake from citrate-chelated zinc was as rapid as from free Zn2+, but EDTA-chelated zinc was not transported. 65Zn uptake assay; ZIP1 overexpression and antisense knockdown in PC-3 cells; kinetic analysis (Vmax, Km) Journal of inorganic biochemistry High 12888280
2007 A di-leucine sorting signal (ETRALL144-149) in the variable loop region of ZIP1 mediates its endocytosis and lysosomal degradation. Alanine substitution of LL148,149 blocked internalization and led to accumulation of ZIP1 on the cell surface; this signal was necessary and sufficient for endocytosis when transferred to a chimeric IL-2 receptor construct. Site-directed mutagenesis; immunofluorescence microscopy; chimeric protein assay (IL-2 receptor alpha-chain fused to ZIP1 loop peptides) The FEBS journal High 17635580
2006 Mouse ZIP1 and ZIP3 together are required for adaptation to dietary zinc deficiency during pregnancy. Double knockout of ZIP1 and ZIP3 caused 91% of embryos to develop abnormally under zinc-deficient diet, with no overt phenotype under zinc-replete conditions, indicating these transporters function in redistribution/retention of zinc rather than primary dietary acquisition. Targeted gene knockout (ZIP1 KO, ZIP1/ZIP3 double KO mice); embryonic morphology assessment under zinc-deficient diet; 67Zn accumulation measurement in liver and pancreas Genesis (New York, N.Y. : 2000) High 16652366
2008 Mouse ZIP1, ZIP2, and ZIP3 (Slc39a1-3) play important, non-compensatory roles in zinc homeostasis specifically during zinc deficiency; triple knockout mice showed no phenotype under zinc-replete conditions but had severely impaired 67Zn accumulation in liver and pancreas and increased embryonic abnormalities under zinc-deficient diet. Triple-knockout mouse generation by targeted mutagenesis; 67Zn isotope accumulation assay; embryonic alkaline phosphatase activity; morphological assessment American journal of physiology. Regulatory, integrative and comparative physiology High 18353881
2005 ZIP1 overexpression in human mesenchymal stem cells (MSCs) induced osteogenic differentiation (Alizarin red-positive mineralization, increased alkaline phosphatase, osteopontin, Cbfa1/Runx2 expression); siRNA-mediated ZIP1 knockdown decreased zinc uptake and inhibited osteoblastic differentiation. ZIP1 localized to plasma membrane and cytoplasm of osteoblastic cells. Adenoviral overexpression of ZIP1; siRNA knockdown; osteogenic differentiation assays (Alizarin red, ALP, gene expression); zinc uptake measurement; immunofluorescence localization Bone Medium 16203195
2005 ZIP1 is expressed in osteoclasts at the plasma membrane and diffusely in the cytoplasm. Adenoviral overexpression of ZIP1 caused its redistribution to colocalize with actin at the sealing zone, significantly inhibited osteoclast resorptive activity, and decreased NF-κB binding activity. Adenoviral overexpression; immunofluorescence localization with actin costaining; resorption assay; EMSA for NF-κB activity Bone Medium 16005272
2011 ZIP1 (Slc39a1) and ZIP3 mediate passive zinc uptake into CA1 hippocampal neurons. In ZIP1/ZIP3 double-knockout mice, passive Zn2+ uptake (measured by intracellular fluorescent Zn dye, with NMDA receptors and voltage-gated Ca2+ channels blocked) was slowed, and kainic acid-induced CA1 neurodegeneration was greatly attenuated in vivo. Zip1/3 double-knockout mice; intracellular fluorescent Zn dye measurement; kainic acid seizure model; pharmacological channel blockade The Journal of neuroscience Medium 21209194
2014 Mouse ZIP1 (mZIP1) mediates saturable zinc uptake with a Michaelis constant of 5.88 μM. Fe2+ and Ni2+ competitively inhibit mZIP1-mediated zinc uptake (Ki 0.92 and 28.6 μM), Co2+ and Cd2+ show non-competitive inhibition, while Mn2+ and Mg2+ have no effect. 65Zn uptake assay in HEK293T cells overexpressing mZIP1 cDNA; kinetic analysis; inhibition studies with divalent cations Life sciences Medium 25089007
2018 SLC39A1 (ZIP1) interacts with Drp1 and the mitochondrial calcium uniporter (MCU) to form a Zip1-MCU complex. Upon Drp1 recruitment to mitochondria, Zip1 mediates Zn2+ entry that focally reduces mitochondrial membrane potential (MMP) at fission sites. Interfering with the Drp1-Zip1 interaction blocked MMP reduction and subsequent mitophagic selection of damaged mitochondria. Co-immunoprecipitation; live imaging of mitochondrial membrane potential; Drp1-Zip1 interaction disruption experiments; mitophagy assay Molecular cell High 30581142
2016 Oxidative stress (H2O2 treatment) increases ZIP1 protein expression in plasma membrane and cellular fractions of cultured mouse astrocytes, leading to increased maximal velocity of 65Zn uptake (increased Vmax with unchanged Km), indicating ZIP1-mediated upregulation of zinc clearance under oxidative stress. 65Zn uptake assay; Western blotting; immunocytochemistry; plasma membrane fractionation in H2O2-treated astrocytes Life sciences Medium 26979775
2022 ZIP1-positive tumour-associated fibroblasts transfer Zn2+ to lung cancer cells via connexin-43-mediated gap junctions. ZIP1 expression on fibroblasts upregulates connexin-43, and ZIP1+ fibroblasts acting as Zn2+ reservoirs transfer zinc to cancer cells, leading to ABCB1-mediated chemoresistance. Single-cell RNA sequencing; gap junction assay; Zn2+ transfer measurement; connexin-43 regulation assay; ABCB1 drug efflux assay Nature communications Medium 36207295
2025 SLC39A1 interacts with DRP1 (dynamin-related protein 1) to facilitate mitochondrial fission and MMP depolarization in HCC cells. DRP1 inhibition abolished SLC39A1-induced mitochondrial division and MMP depolarization; DRP1 overexpression rescued mitochondrial fusion and cell proliferation in SLC39A1-silenced cells. A peptide disrupting the SLC39A1-DRP1 interaction suppressed HCC progression. Co-immunoprecipitation; molecular docking; DRP1 inhibition/overexpression rescue experiments; mitochondrial morphology and MMP assays; liver-specific SLC39A1 knockout mouse model Clinical and translational medicine Medium 40462487
2023 Loss of ZIP1 and ZIP3 in platelets increases free intracellular Zn2+ content and enhances GPCR-coupled (but not ITAM-coupled) platelet activation responses, resulting in enhanced thrombin-induced aggregation, larger thrombus volume ex vivo, and faster in vivo thrombus formation. This was accompanied by enhanced Ca2+, PKC, CamKII, and ERK1/2 signaling. ZIP1/ZIP3 double-knockout mice; ICP-MS Zn2+ measurement; FluoZin3 free Zn2+ staining; platelet aggregation assay; ex vivo flow chamber thrombosis; intravital microscopy in vivo thrombus assay; signaling pathway analysis Frontiers in immunology Medium 37359521
1999 Human/mammalian ZIP1 (ZIRTL/SLC39A1) gene was mapped to chromosome 1q21 within the epidermal differentiation complex. mRNA was detected in most adult and fetal tissues. Mouse gene maps to chromosome 3 between S100A9 and S100A13, and is developmentally regulated in suprabasal epidermis, osteoblasts, small intestine, and salivary gland. Genomic mapping; Northern blot/in situ hybridization for tissue expression; cDNA cloning Genomics Low 10610721
2026 In alveolar type II (AT2) cells, SLC39A1 governs zinc uptake required for protection against acute lung injury. Zinc directly binds to and activates TFEB, TFE3, and MITF, inducing transcriptional activation of autophagy to eliminate damaged mitochondria and suppress apoptosis/pyroptosis. Epistasis experiments placing SLC39A1 upstream of autophagy (Lc3b) showed that AAV-shLc3b in AT2 Slc39a1-deficient mice did not further aggravate lung injury, positioning SLC39A1 in a linear pathway upstream of LC3B-dependent autophagy. AT2-specific Slc39a1 conditional knockout mice; SLC39A1 overexpression; zinc chelation/supplementation; TFEB/TFE3/MITF binding assay; autophagy measurement; epistasis by combined Slc39a1 KO and shLc3b AAV Nature communications High 42045244
2026 SLC39A1 overexpression in pancreatic cancer cells elevates intracellular zinc levels and activates the Src/FAK signaling pathway, promoting cancer cell migration and invasion. Zinc chelation or Src/FAK inhibitors suppressed SLC39A1-induced migration/invasion, and SLC39A1 knockdown inhibited liver metastasis in a mouse model. SLC39A1 KD/OE in PC cells; Transwell invasion and scratch assays; 3D spheroid assay; Western blot for Src/FAK phosphorylation; zinc chelation; in vivo mouse liver metastasis model International journal of biological macromolecules Medium 42208832

Source papers

Stage 0 corpus · 52 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1993 ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis. Cell 541 7916652
2001 The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells. The Journal of biological chemistry 223 11301334
1995 Zip1-induced changes in synaptonemal complex structure and polycomplex assembly. The Journal of cell biology 149 7860625
1996 Synaptonemal complex (SC) component Zip1 plays a role in meiotic recombination independent of SC polymerization along the chromosomes. Proceedings of the National Academy of Sciences of the United States of America 143 8799151
2003 Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells. Journal of inorganic biochemistry 128 12888280
1999 Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. Science (New York, N.Y.) 115 10477520
2000 Organization of the yeast Zip1 protein within the central region of the synaptonemal complex. The Journal of cell biology 109 10662769
2018 Drp1-Zip1 Interaction Regulates Mitochondrial Quality Surveillance System. Molecular cell 105 30581142
1998 Meiotic chromosome morphology and behavior in zip1 mutants of Saccharomyces cerevisiae. Genetics 94 9611194
2006 Mouse ZIP1 and ZIP3 genes together are essential for adaptation to dietary zinc deficiency during pregnancy. Genesis (New York, N.Y. : 2000) 87 16652366
2005 Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells. Bone 68 16203195
2011 Knockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience 63 21209194
2009 The synaptonemal complex protein, Zip1, promotes the segregation of nonexchange chromosomes at meiosis I. Proceedings of the National Academy of Sciences of the United States of America 61 20080752
2009 The synaptonemal complex protein Zip1 promotes bi-orientation of centromeres at meiosis I. PLoS genetics 58 20011112
2005 SCF(Pof1)-ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast. The EMBO journal 52 15660136
2022 The transcription factor ZIP-1 promotes resistance to intracellular infection in Caenorhabditis elegans. Nature communications 48 35013162
1999 Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex. Genomics 48 10610721
2015 Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis. PLoS biology 46 26682552
2008 Slc39a1 to 3 (subfamily II) Zip genes in mice have unique cell-specific functions during adaptation to zinc deficiency. American journal of physiology. Regulatory, integrative and comparative physiology 40 18353881
2005 Expression of the zinc transporter ZIP1 in osteoclasts. Bone 37 16005272
2015 Separable Crossover-Promoting and Crossover-Constraining Aspects of Zip1 Activity during Budding Yeast Meiosis. PLoS genetics 33 26114667
2019 Crossover recombination and synapsis are linked by adjacent regions within the N terminus of the Zip1 synaptonemal complex protein. PLoS genetics 30 31220082
2009 Localization of zip1 and zip4 mRNA in the adult rat brain. Journal of neuroscience research 30 19530166
2007 A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein. The FEBS journal 27 17635580
2022 ZIP1+ fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn2+ transfer. Nature communications 26 36207295
2007 A novel nonnull ZIP1 allele triggers meiotic arrest with synapsed chromosomes in Saccharomyces cerevisiae. Genetics 22 17435220
2016 Oxidative stress upregulates zinc uptake activity via Zrt/Irt-like protein 1 (ZIP1) in cultured mouse astrocytes. Life sciences 19 26979775
2000 Exclusion of ZIRTL as candidate gene of juvenile hemochromatosis and refinement of the critical interval on 1q21. Blood cells, molecules & diseases 18 10950940
2007 Regulation of branchial zinc uptake by 1alpha,25-(OH)(2)D(3) in rainbow trout and associated changes in expression of ZIP1 and ECaC. Aquatic toxicology (Amsterdam, Netherlands) 17 17651823
2012 Cadmium-induced proteome remodeling regulated by Spc1/Sty1 and Zip1 in fission yeast. Toxicological sciences : an official journal of the Society of Toxicology 15 22610605
2015 Melatonin exerts protective effect on N2a cells under hypoxia conditions through Zip1/ERK pathway. Neuroscience letters 14 25864781
2014 ZIP1 and zinc inhibits fluoride-induced apoptosis in MC3T3-E1 cells. Biological trace element research 13 24752969
2018 Evidence of Zip1 Promoting Sister Kinetochore Mono-orientation During Meiosis in Budding Yeast. G3 (Bethesda, Md.) 12 30254179
2013 Zip1, Zip2, and Zip8 mRNA expressions were associated with growth hormone level during the growth hormone provocation test in children with short stature. Biological trace element research 12 23921484
2014 The effect of divalent metal cations on zinc uptake by mouse Zrt/Irt-like protein 1 (ZIP1). Life sciences 11 25089007
2011 Spartin recruits PKC-ζ via the PKC-ζ-interacting proteins ZIP1 and ZIP3 to lipid droplets. Journal of neurochemistry 10 21707618
2018 A ZIP1 separation-of-function allele reveals that centromere pairing drives meiotic segregation of achiasmate chromosomes in budding yeast. PLoS genetics 9 30091974
2022 Integrated analysis of transcriptomics, proteomics and metabolomics data reveals the role of SLC39A1 in renal cell carcinoma. Frontiers in cell and developmental biology 6 36407113
2020 Role of Zip1 in the regulation of NPY expression by MLT to promote fracture healing in rats. European journal of histochemistry : EJH 5 33334091
2024 Plasmodium falciparum ZIP1 Is a Zinc-Selective Transporter with Stage-Dependent Targeting to the Apicoplast and Plasma Membrane in Erythrocytic Parasites. ACS infectious diseases 4 38163252
2025 Coordination of SLC39A1 and DRP1 facilitates HCC recurrence by impairing mitochondrial quality control. Clinical and translational medicine 3 40462487
2023 Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo. Frontiers in immunology 3 37359521
2009 Separation of roles of Zip1 in meiosis revealed in heterozygous mutants of Saccharomyces cerevisiae. Molecular genetics and genomics : MGG 3 19714362
2024 The c.503A>G polymorphism in ZIP1-II of Pacific oyster Crassostrea gigas associated with zinc content. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2 38768804
2024 A Zinc Uptake Transporter ZIP1-II Is Involved in Zinc Accumulation in the Hepatopancreas of Pacific Oyster Crassostrea gigas. Marine biotechnology (New York, N.Y.) 2 39601959
2002 [CG17604 gene from Drosophila melanogaster--possible functional homolog of the yeast ZIP1 and SCP1 (SYCP1) mammalian genes, coding for synaptonemal complex proteins]. Genetika 2 11852789
2025 Quantitative detection of the maize phytocytokine Zip1 utilizing ELISA. Journal of experimental botany 1 39673776
2025 Crossover formation and coordinated assembly of synaptonemal complex relies on a direct interaction between Zip1 and Zip3. bioRxiv : the preprint server for biology 1 41332580
2026 Crossover formation and coordinated assembly of synaptonemal complex relies on a direct interaction between Zip1 and Zip3. Genetics 0 41894234
2026 Epithelial SLC39A1 prevents acute lung injury through zinc-mediated transcriptional activation of autophagy in male mice. Nature communications 0 42045244
2026 Intestinal and epidermal-specific analysis of ZIP-1 function and expression in Caenorhabditis elegans. microPublication biology 0 42079378
2026 SLC39A1 promotes pancreatic cancer metastasis by elevating intracellular zinc and activating the Src/FAK signaling pathway. International journal of biological macromolecules 0 42208832

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