Affinage

SLC25A10

Mitochondrial dicarboxylate carrier · UniProt Q9UBX3

Length
287 aa
Mass
31.3 kDa
Annotated
2026-06-10
100 papers in source corpus 12 papers cited in narrative 12 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/7 claims corpus-supported (86%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC25A10 (the dicarboxylate carrier, DIC) is a mitochondrial inner-membrane transporter that moves dicarboxylates such as malate across the membrane to supply citrate export for de novo fatty acid synthesis, linking it to lipogenesis, redox homeostasis, and oxidative phosphorylation (PMID:16027120). Its transport activity feeds NADPH production and cellular redox balance: knockdown shifts metabolism away from glycolysis toward mitochondrial respiration, raises sensitivity to oxidative stress, and lowers NADPH under glutamine deprivation (PMID:25797253), and in differentiated adipocytes the carrier supports insulin-stimulated lipogenesis through its transport function rather than transcriptional regulation (PMID:28570579). At the organellar level the carrier promotes mitochondrial cristae formation and thereby tunes oxygen consumption, ATP content, and ROS levels (PMID:19210547). Biallelic loss-of-function mutations in SLC25A10 cause loss of the protein and its transport activity, complex I deficiency, mitochondrial DNA depletion, and severe epileptic encephalopathy, with transport assays showing the carrier does not transport glutathione (PMID:29211846). Biogenesis of the carrier proceeds by a membrane-potential-independent translocation pathway that accumulates a soluble intermembrane-space intermediate distinct from the ADP/ATP carrier import route (PMID:11502005). The protein is bound directly by the circadian clock protein CLOCK through defined sites required for its support of glucose homeostasis, redox balance, and electron transport chain function (PMID:30943427), and it is stabilized against ubiquitination-dependent degradation by MPV17 within an Nrf2–MPV17–SLC25A10 axis governing mitochondrial glutathione handling and ferroptosis (PMID:39409161). In cancer contexts SLC25A10 acts downstream of PYCR1 to suppress lipid ROS and ferroptosis (PMID:36104652).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2001 High

    Established how the dicarboxylate carrier is delivered to mitochondria, defining a biogenesis route distinct from canonical carrier import.

    Evidence In vitro import assays in yeast mitochondria with membrane-potential manipulation, compared against the ADP/ATP carrier

    PMID:11502005

    Open questions at the time
    • Does not identify the protein machinery handling the soluble intermembrane-space intermediate
    • Performed in yeast; human-specific import determinants not addressed
  2. 2005 Medium

    Connected SLC25A10 transport activity to a metabolic output, showing it supplies malate for citrate export feeding de novo fatty acid synthesis.

    Evidence siRNA knockdown in HepG2 and 3T3-L1 cells with citrate transport, ACC1, malonyl-CoA, and triglyceride readouts

    PMID:16027120

    Open questions at the time
    • Substrate selectivity not directly measured in this system
    • Single lab; in vitro cell models only
  3. 2009 Medium

    Demonstrated an organellar structural role, linking carrier abundance to cristae formation and the efficiency of oxidative phosphorylation.

    Evidence Overexpression and RNAi of the C. elegans ortholog DIC-1 with cryo-EM cristae morphometry plus ATP, ROS, and paraquat-sensitivity assays

    PMID:19210547

    Open questions at the time
    • Mechanism linking dicarboxylate transport to cristae remodeling unknown
    • Ortholog-based; human relevance inferred
  4. 2015 Medium

    Placed SLC25A10 in redox and metabolic reprogramming, showing its loss forces oxidative metabolism and impairs NADPH-dependent stress defense in cancer cells.

    Evidence siRNA knockdown in A549 cells with metabolic flux, NADPH, ROS, oxygen consumption, and gene-expression readouts

    PMID:25797253

    Open questions at the time
    • Causal link between transport flux and HIF-1α/LDH/GDH changes not resolved
    • Single cell line
  5. 2017 Medium

    Distinguished transport function from transcriptional effects, showing the carrier supports adipocyte insulin-stimulated lipogenesis directly.

    Evidence siRNA knockdown in differentiated human adipocytes with lipogenesis assay and microarray transcriptome profiling

    PMID:28570579

    Open questions at the time
    • Does not define which transported metabolite mediates the insulin effect
    • Single lab
  6. 2018 High

    Provided human genetic proof of essentiality, tying loss of the carrier to mitochondrial respiratory failure and disease, and excluding glutathione as a substrate at that point.

    Evidence Whole-exome sequencing of a patient, fibroblast functional analysis, yeast ortholog knockout, and transport assays

    PMID:29211846

    Open questions at the time
    • Mechanism linking transport loss to mtDNA depletion and complex I deficiency unresolved
    • Single patient
  7. 2018 Low

    Tested pharmacological modulation, linking metformin action on cancer metabolism to suppression of SLC25A10 expression.

    Evidence siRNA knockdown plus metformin treatment in A549 cells with qRT-PCR, western blot, and CDKN1A readouts

    PMID:30222970

    Open questions at the time
    • Expression-only correlation; no direct transport or mechanistic assay
    • Causality between metformin and SLC25A10 not established
  8. 2019 Medium

    Identified a direct protein partner, showing CLOCK binds defined SLC25A10 sites that are functionally required for glucose homeostasis and ETC support.

    Evidence Reciprocal Co-IP, CRISPR/Cas9 knockout, and rescue with wild-type versus CLOCK-binding-site mutant in Hepa1-6 cells

    PMID:30943427

    Open questions at the time
    • Functional consequence of the CLOCK–SLC25A10 interaction at the molecular level unclear
    • No structural model of the interaction
  9. 2020 Low

    Linked SLC25A10 to proliferative control in tumor cells via cell-cycle protein regulation.

    Evidence shRNA knockdown in osteosarcoma cells with proliferation, apoptosis, mitosis, and CCNE1/P21/P27 readouts

    PMID:32774476

    Open questions at the time
    • No direct mechanistic link between transport activity and cell-cycle protein regulation
    • Single knockdown approach
  10. 2022 Medium

    Positioned SLC25A10 as a ferroptosis-suppressing effector downstream of PYCR1 in cancer.

    Evidence Knockdown/overexpression epistasis in colorectal cancer cells with lipid ROS, ferroptosis inducer/inhibitor experiments, and in vivo tumor models

    PMID:36104652

    Open questions at the time
    • Molecular mechanism by which PYCR1 controls SLC25A10 expression unknown
    • Transported substrate mediating ferroptosis resistance not identified
  11. 2024 Medium

    Defined a stability-control axis and assigned a glutathione-transport role, showing MPV17 protects SLC25A10 from ubiquitination-dependent degradation to maintain mitochondrial glutathione import.

    Evidence MPV17 overexpression, protein stability and ubiquitination assays, and mitochondrial glutathione measurement in cardiomyocyte iron-overload and I/R models

    PMID:39409161

    Open questions at the time
    • Glutathione-transport assignment conflicts with earlier transport assays excluding glutathione (#2)
    • E3 ligase mediating degradation not identified
  12. 2024 Low

    Implicated SLC25A10 as a mediator of cardioprotection, showing its expression is suppressed in I/R injury and restored by mild therapeutic hypothermia.

    Evidence Proteomics, siRNA/gene deletion, and mitochondrial apoptosis pathway readouts in H/R cardiomyocytes and I/R rat model

    PMID:38568407

    Open questions at the time
    • Proteomics-identified target with only partial genetic validation
    • No direct transport assay linking carrier function to protection

Open questions

Synthesis pass · forward-looking unresolved questions
  • The substrate spectrum of SLC25A10 remains unsettled, with transport assays excluding glutathione yet a glutathione-import role asserted via the MPV17 axis.
  • Definitive reconstituted determination of physiological substrates (malate, succinate, phosphate, sulfate, glutathione) is unresolved
  • Mechanism connecting transport flux to cristae formation and mtDNA maintenance unknown
  • Structural basis of CLOCK and MPV17 interactions undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 3 GO:0140104 molecular carrier activity 2
Localization
GO:0005739 mitochondrion 3
Pathway
R-HSA-1430728 Metabolism 3 R-HSA-5357801 Programmed Cell Death 2
Partners
CLOCKMPV17PYCR1

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 SLC25A10 (Slc25a10) transports malate across the mitochondrial inner membrane to supply malate for citrate export during de novo fatty acid synthesis. siRNA-mediated knockdown of Slc25a10 in HepG2 and 3T3-L1 cells significantly reduced citrate transport from mitochondria to cytosol, decreased ACC1 expression and malonyl-CoA levels, and reduced triglyceride accumulation in differentiated adipocytes. siRNA knockdown in HepG2 and 3T3-L1 cell lines; measurement of citrate transport, ACC1 expression, malonyl-CoA levels, and triglyceride accumulation The Journal of biological chemistry Medium 16027120
2015 SLC25A10 knockdown in A549 lung cancer cells shifted energy metabolism from glycolysis toward mitochondrial oxidative phosphorylation, increased glutamine dependency, increased sensitivity to oxidative stress, decreased NADPH production under glutamine deprivation, and reduced malignant growth properties. These effects were linked to decreased HIF-1α and lactate dehydrogenase expression and increased glutamate dehydrogenase expression. siRNA knockdown in A549 cells; measurement of cell growth, ROS levels, NADPH production, gene expression (HIF-1α, LDH, GDH), oxygen consumption, and metabolic parameters Oncotarget Medium 25797253
2018 Biallelic loss-of-function mutations in SLC25A10 in a patient caused absence of SLC25A10 protein and loss of its transporting function, associated with respiratory complex I deficiency, mitochondrial DNA depletion, and severe epileptic encephalopathy. The yeast SLC25A10 ortholog knockout showed defects in mitochondrial respiration and mitochondrial DNA content. Transport assays demonstrated that SLC25A10 is unable to transport glutathione despite patient fibroblasts being depleted in NADPH and glutathione. Whole exome sequencing; patient fibroblast functional analysis; yeast ortholog knockout; transport assays; RNA and protein quantification Human molecular genetics High 29211846
2019 The circadian clock protein CLOCK directly binds SLC25A10 protein. Amino acids 43–84 and 169–210 in SLC25A10 are key sites mediating CLOCK binding. Loss of SLC25A10 (CRISPR/Cas9 knockout in Hepa1-6 cells) caused disordered glucose homeostasis, increased oxidative stress, and damaged electron transport chain function. Rescue with wild-type SLC25A10 restored these defects, while a mutant lacking the CLOCK-binding sites failed to rescue, establishing these sites as functionally required. Co-immunoprecipitation; CRISPR/Cas9 knockout cell line generation; rescue with wild-type vs. mutant SLC25A10; measurement of glucose metabolism, ROS, and electron transport chain function Biochimica et biophysica acta. Molecular cell research Medium 30943427
2001 Import of the dicarboxylate carrier (DIC/SLC25A10) into mitochondria follows a distinct pathway from the ADP/ATP carrier (AAC): DIC shows complete membrane potential (ΔΨ)-independent translocation across the outer mitochondrial membrane and release from the import pore, accumulating in a soluble state in the intermembrane space (stage III*). This defines a new translocation intermediate distinct from other mitochondrial carriers. In vitro mitochondrial import assays using yeast Saccharomyces cerevisiae mitochondria; comparison with AAC import pathway; membrane potential manipulation Journal of molecular biology High 11502005
2009 Over-expression of DIC-1 (C. elegans ortholog of SLC25A10) greatly increased the number and fractional area of mitochondrial cristae, increased oxygen consumption rate and ATP content, and decreased reactive oxygen species and paraquat sensitivity. Conversely, DIC-1 knockdown induced opposite changes in ATP, ROS, and paraquat sensitivity, demonstrating that DIC-1 actively participates in cristae formation and thereby regulates oxidative phosphorylation. Transient over-expression in C. elegans; cryo-electron microscopy of mitochondrial morphology; measurement of oxygen consumption, ATP content, ROS levels, and paraquat sensitivity; RNAi knockdown Genes to cells : devoted to molecular & cellular mechanisms Medium 19210547
2018 Metformin treatment decreased SLC25A10 gene and protein expression in A549 lung cancer cells, with the effect more pronounced at low glucose concentrations. In SLC25A10 knockdown cells, metformin significantly further reduced SLC25A10 at both mRNA and protein levels and markedly increased expression of the cyclin-dependent kinase inhibitor CDKN1A (p21), suggesting that metformin can affect nutrient supply and metabolic state of cancer cells through SLC25A10. siRNA knockdown; metformin treatment; qRT-PCR and western blot for SLC25A10 and metabolic gene expression; growth at varying glucose concentrations Biochemical pharmacology Low 30222970
2017 siRNA knockdown of SLC25A10 in in vitro differentiated human adipocytes inhibited insulin-stimulated lipogenesis under conditions where glucose transport is the rate-limiting step. Transcriptome profiling of siRNA-treated cells showed only modest transcriptional changes, suggesting SLC25A10 directly influences insulin sensitivity in adipocytes through its transport function rather than transcriptional regulation. siRNA knockdown in differentiated human adipocytes; measurement of insulin-stimulated lipogenesis; microarray transcriptome profiling PloS one Medium 28570579
2022 PYCR1 promoted SLC25A10 expression in colorectal cancer cells. SLC25A10 overexpression reversed the antitumor effects of PYCR1 silencing in vitro, including restoration of lipid ROS suppression and inhibition of ferroptosis. In vivo, SLC25A10 overexpression inhibited the antitumor effects of the ferroptosis inducer erastin, establishing SLC25A10 as a downstream effector of PYCR1 in suppressing ferroptosis. siRNA knockdown and overexpression in colorectal cancer cells; lipid ROS measurement; ferroptosis inhibitor/inducer experiments (deferoxamine, erastin); in vivo tumor models Human cell Medium 36104652
2020 SLC25A10 knockdown in osteosarcoma cells significantly suppressed cell proliferation, increased apoptosis, and decreased mitosis. SLC25A10 positively regulated CCNE1 (Cyclin E1) expression while negatively regulating P21 and P27, suggesting SLC25A10 promotes osteosarcoma cell growth through regulation of cell cycle proteins. shRNA knockdown; cell counting, MTT assay, colony formation assay; flow cytometry for apoptosis and mitosis; western blot for CCNE1, P21, P27 Oncology letters Low 32774476
2024 MPV17 maintains the protein homeostasis of SLC25A10 by preventing its ubiquitination-dependent degradation during iron overload conditions. MPV17 absence in iron overload resulted in degradation of SLC25A10, impairing mitochondrial glutathione import. SLC25A10 functions as a mitochondrial inner-membrane glutathione transporter, and the Nrf2-MPV17-SLC25A10/mitochondrial glutathione axis regulates myocardial ferroptosis. Adenovirus-mediated MPV17 overexpression; SLC25A10 protein stability assay; ubiquitination assay; mitochondrial glutathione measurement; cardiomyocyte iron overload and I/R models International journal of molecular sciences Medium 39409161
2024 SLC25A10 expression was suppressed in ischemia/reperfusion (I/R) rat myocardium and in hypoxia/reoxygenation (H/R) cardiomyocytes. Mild therapeutic hypothermia (MTH) reversed this suppression. SLC25A10 deletion partially reversed the protective effects of MTH on H/R cardiomyocytes, including reversal of the inhibition of the mitochondrial apoptosis pathway, establishing SLC25A10 as a mediator of MTH cardioprotection against I/R injury. Proteomics identification; siRNA/gene deletion of SLC25A10; measurement of cell injury markers, mitochondrial dysfunction, and mitochondrial apoptosis pathway activation in H/R cardiomyocytes and I/R rat model Journal of cardiovascular translational research Low 38568407

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2015 DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC. Blood reviews 136 26776504
2014 PAMPs and DAMPs as triggers for DIC. Journal of intensive care 120 25705424
2013 Differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS). Journal of thrombosis and haemostasis : JTH 88 23522358
1986 Deletion mapping of the testis determining locus with DNA probes in 46,XX males and in 46,XY and 46,X,dic(Y) females. Nucleic acids research 86 3748818
1998 Antithrombin: its physiological importance and role in DIC. Seminars in thrombosis and hemostasis 83 9515776
2014 DIC score in pregnant women--a population based modification of the International Society on Thrombosis and Hemostasis score. PloS one 80 24728139
2005 Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. The Journal of biological chemistry 77 16027120
2017 Density imaging of heterochromatin in live cells using orientation-independent-DIC microscopy. Molecular biology of the cell 75 28835378
1995 Further evidence that CENP-C is a necessary component of active centromeres: studies of a dic(X; 15) with simultaneous immunofluorescence and FISH. Human molecular genetics 69 7757082
1996 Age-related differences in outcome and severity of DIC in children with septic shock and purpura. Thrombosis and haemostasis 62 8972013
2021 Recent advances in the research and management of sepsis-associated DIC. International journal of hematology 60 33386597
2000 Description of compensated and uncompensated disseminated intravascular coagulation (DIC) responses (non-overt and overt DIC) in baboon models of intravenous and intraperitoneal Escherichia coli sepsis and in the human model of endotoxemia: toward a better definition of DIC. Critical care medicine 59 11007191
2015 Recent advances in disseminated intravascular coagulation: endothelial cells and fibrinolysis in sepsis-induced DIC. Journal of intensive care 56 27408725
2019 Repeat dose exposure of PM2.5 triggers the disseminated intravascular coagulation (DIC) in SD rats. The Science of the total environment 55 30711591
2003 PAX5/ETV6 fusion defines cytogenetic entity dic(9;12)(p13;p13). Leukemia 54 12764378
1997 dic(5;17): a recurring abnormality in malignant myeloid disorders associated with mutations of TP53. Genes, chromosomes & cancer 52 9365836
2006 Characterisation of dic(9;20)(p11-13;q11) in childhood B-cell precursor acute lymphoblastic leukaemia by tiling resolution array-based comparative genomic hybridisation reveals clustered breakpoints at 9p13.2 and 20q11.2. British journal of haematology 50 16999846
2015 The mitochondrial carrier SLC25A10 regulates cancer cell growth. Oncotarget 47 25797253
2000 Disseminated intravascular coagulation (DIC). Clinical laboratory science : journal of the American Society for Medical Technology 47 11586511
2018 SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency. Human molecular genetics 45 29211846
2001 Diagnosis and management of acute obstetrical DIC. Seminars in thrombosis and hemostasis 43 11372771
1995 dic(9;20): a new recurrent chromosome abnormality in adult acute lymphoblastic leukemia. Genes, chromosomes & cancer 42 7541644
2002 Waveform analysis of clotting test optical profiles in the diagnosis and management of disseminated intravascular coagulation (DIC). Clinical and laboratory haematology 41 12452811
2000 Biophysical and structural properties of DNA.diC(14)-amidine complexes. Influence of the DNA/lipid ratio. The Journal of biological chemistry 39 10896680
2009 Heterogeneous breakpoints in patients with acute lymphoblastic leukemia and the dic(9;20)(p11-13;q11) show recurrent involvement of genes at 20q11.21. Haematologica 34 19586940
2005 Detection of nuclei in 4D Nomarski DIC microscope images of early Caenorhabditis elegans embryos using local image entropy and object tracking. BMC bioinformatics 34 15910690
2017 Global transcriptome profiling identifies KLF15 and SLC25A10 as modifiers of adipocytes insulin sensitivity in obese women. PloS one 30 28570579
1980 Dic(21;21) in a Down's syndrome child with an unusual chromosome 9 variant in the mother. Journal of medical genetics 30 6445984
2012 Tanshinone IIA protects rabbits against LPS-induced disseminated intravascular coagulation (DIC). Acta pharmacologica Sinica 29 22983394
1996 Effects of recombinant human tissue factor pathway inhibitor on thrombus formation and its in vivo distribution in a rat DIC model. American journal of clinical pathology 29 8929465
1995 Dicentric (9;12) in acute lymphocytic leukemia and other hematological malignancies: report from a dic(9;12) study group. Leukemia 27 7845002
1993 The effect of a long-acting recombinant hirudin (PEG-hirudin) on experimental disseminated intravascular coagulation (DIC) in rabbits. Thrombosis research 27 8475480
2002 Biophysical and transfection studies of the diC(14)-amidine/DNA complex. Biophysical journal 26 12023234
2019 The circadian protein CLOCK regulates cell metabolism via the mitochondrial carrier SLC25A10. Biochimica et biophysica acta. Molecular cell research 25 30943427
2008 Clinical and cytogenetic features of pediatric dic(9;20)(p13.2;q11.2)-positive B-cell precursor acute lymphoblastic leukemias: a Nordic series of 24 cases and review of the literature. Genes, chromosomes & cancer 25 17990329
2005 DIC image reconstruction on large cell scans. Microscopy research and technique 25 16003783
2020 Identification of hemostatic markers that define the pre-DIC state: A multi-center observational study. Journal of thrombosis and haemostasis : JTH 24 32573898
1992 Fluctuations in plasma levels of thrombomodulin in patients with DIC. Thrombosis and haemostasis 24 1333099
2022 The role of PYCR1 in inhibiting 5-fluorouracil-induced ferroptosis and apoptosis through SLC25A10 in colorectal cancer. Human cell 23 36104652
2024 Orientation-independent-DIC imaging reveals that a transient rise in depletion attraction contributes to mitotic chromosome condensation. Proceedings of the National Academy of Sciences of the United States of America 22 39190347
2013 Down-regulated expression of AQP5 on lung in rat DIC model induced by LPS and its effect on the development of pulmonary edema. Pulmonary pharmacology & therapeutics 22 23538169
2013 Effects of quercetin on LPS-induced disseminated intravascular coagulation (DIC) in rabbits. Thrombosis research 22 23571140
1990 Amylase-producing plasmacytoma cell lines, AD3 and FR4, with der(14)t(8;14) and dic(8)t(1;8) established from ascites. Leukemia 22 1697013
1990 Fibrinolysis as a feature of disseminated intravascular coagulation (DIC) after Pseudonaja textilis textilis envenomation. Thrombosis research 21 2237840
2014 Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients. Drug design, development and therapy 20 25214765
2010 Evaluation of modified non-overt DIC criteria on the prediction of poor outcome in patients with sepsis. Thrombosis research 20 20079919
2003 Meiotic behavior of the sex chromosomes in a 45,X/46,X,r(Y)/46,X,dic r(Y) patient whose semen was assessed by fluorescence in situ hybridization. Fertility and sterility 20 12749430
2001 Biogenesis of the dicarboxylate carrier (DIC): translocation across the mitochondrial outer membrane and subsequent release from the TOM channel are membrane potential-independent. Journal of molecular biology 20 11502005
1990 Role of activated platelets in endotoxin-induced DIC in rats. Thrombosis research 20 2080492
1983 A histological study on microthrombi in autopsy cases of DIC. Bibliotheca haematologica 20 6421274
2002 A point mutation, R59G, within the HMG-SRY box in a female 45,X/46,X, psu dic(Y)(pter-->q11::q11-->pter). Human genetics 19 12215836
1982 Left-handed helices for DNA: studies on poly[d(I-C)]. Proceedings of the National Academy of Sciences of the United States of America 19 6959102
2009 Deviance Information Criterion (DIC) in Bayesian Multiple QTL Mapping. Computational statistics & data analysis 18 20161286
1996 dic(4;17)(p11;p11): a new recurrent chromosomal abnormality in chronic B-lymphoid disorders. Genes, chromosomes & cancer 18 8946198
2008 Disseminated intravascular coagulation (DIC) and non-small cell lung cancer (NSCLC): report of a case and review of the literature. Lung cancer (Amsterdam, Netherlands) 17 19070399
1995 VE-DIC light microscopy and the discovery of kinesin. Trends in cell biology 17 14732150
2020 PECAM-1 protects against DIC by dampening inflammatory responses via inhibiting macrophage pyroptosis and restoring vascular barrier integrity. Translational research : the journal of laboratory and clinical medicine 16 32417429
2020 Nonovert disseminated intravascular coagulation (DIC) in pregnancy: a new scoring system for the identification of patients at risk for obstetrical hemorrhage requiring blood product transfusion. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 15 31931643
2018 An orientation-independent DIC microscope allows high resolution imaging of epithelial cell migration and wound healing in a cnidarian model. Journal of microscopy 15 29345317
2024 The ISTH DIC-score predicts early mortality in patients with non-promyelocitic acute myeloid leukemia. Thrombosis research 14 38387301
2024 YOD1 protects against MRSA sepsis-induced DIC through Lys33-linked deubiquitination of NLRP3. Cell death & disease 14 38789414
2022 High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium. mBio 14 35100876
2018 Metformin downregulates the mitochondrial carrier SLC25A10 in a glucose dependent manner. Biochemical pharmacology 14 30222970
1996 Ambiguous genitalia in an elderly woman with a mosaic 45,X/46,X,dic(Y)(Q11.2) karyotype. Urology 14 8607249
2020 Influence of Instant Controlled Pressure Drop (DIC) on Allergenic Potential of Tree Nuts. Molecules (Basel, Switzerland) 13 32290123
2020 SLC25A10 performs an oncogenic role in human osteosarcoma. Oncology letters 13 32774476
1998 Three patients with a 45,X/46,X,psu dic(Xp) karyotype. Journal of medical genetics 13 9643298
1975 [45,X/46,SYq dic-Sexchromosome mosaic]. Humangenetik 13 1150238
2018 Examination of biomarker expressions in sepsis-related DIC patients. International journal of general medicine 12 30254480
2009 Focal adhesion kinase (FAK) immunocytochemical expression in breast ductal invasive carcinoma (DIC): correlation with clinicopathological parameters and tumor proliferative capacity. Medical science monitor : international medical journal of experimental and clinical research 12 19644410
2018 BMSCs pre-treatment ameliorates inflammation-related tissue destruction in LPS-induced rat DIC model. Cell death & disease 11 30282969
2016 OC-16 - Neutrophil extracellular traps and tissue factor-bearing microvesicles: a liaison dangereuse causing overt DIC in cancer patients? Thrombosis research 11 27161688
2007 A FISH comparison of variant derivatives of the recurrent dic(17;20) of myelodysplastic syndromes and acute myeloid leukemia: Obligatory retention of genes on 17p and 20q may explain the formation of dicentric chromosomes. Genes, chromosomes & cancer 11 17048234
1998 Towards automatic cell identification in DIC microscopy. Journal of microscopy 11 9853375
1989 Heparin cofactor II in adults and infants with thrombosis and DIC. American journal of hematology 11 2525333
2018 Acute haemolysis, DIC and renal failure after transfusion of uncross-matched blood during trauma resuscitation: illustrative case and literature review. Transfusion medicine (Oxford, England) 10 29460456
2013 Hematologic manifestations of systemic disease (including iron deficiency, anemia of inflammation and DIC). Pediatric clinics of North America 10 24237974
2009 DIC-1 over-expression enhances respiratory activity in Caenorhabditis elegans by promoting mitochondrial cristae formation. Genes to cells : devoted to molecular & cellular mechanisms 10 19210547
2009 Dic(17;18)(p11.2;p11.2) is a recurring abnormality in chronic lymphocytic leukaemia associated with aggressive disease. British journal of haematology 10 20015097
2010 Live-cell tracking using SIFT features in DIC microscopic videos. IEEE transactions on bio-medical engineering 9 20483698
2009 Recombinant human antithrombin expressed in the milk of non-transgenic goats exhibits high efficiency on rat DIC model. Journal of thrombosis and thrombolysis 9 19455283
2007 Tiling resolution array CGH of dic(7;9)(p11 approximately 13;p11 approximately 13) in B-cell precursor acute lymphoblastic leukemia reveals clustered breakpoints at 7p11.2 approximately 12.1 and 9p13.1. Cytogenetic and genome research 9 17901695
2021 The carbon partitioning of glucose and DIC in mixotrophic, heterotrophic and photoautotrophic cultures of Tetraselmis suecica. Biotechnology letters 8 33459952
2009 Characterization of the cationic DiC(14)-amidine bilayer by mixed DMPC/DiC(14)-amidine molecular dynamics simulations shows an interdigitated nonlamellar bilayer phase. Langmuir : the ACS journal of surfaces and colloids 8 19231818
2000 Role of DIC in multiple organ failure. International journal of surgical investigation 8 12774341
1996 Swift transformation and locomotion of polymorphonuclear leukocytes and microglia as observed by VEC-DIC microscopy (video microscopy). The Keio journal of medicine 8 8897764
2024 Mild Therapeutic Hypothermia Alleviated Myocardial Ischemia/Reperfusion Injury via Targeting SLC25A10 to Suppress Mitochondrial Apoptosis. Journal of cardiovascular translational research 7 38568407
2024 MPV17 Prevents Myocardial Ferroptosis and Ischemic Cardiac Injury through Maintaining SLC25A10-Mediated Mitochondrial Glutathione Import. International journal of molecular sciences 7 39409161
2023 Labor and delivery: DIC, HELLP, preeclampsia. Hematology. American Society of Hematology. Education Program 7 38066933
2019 Lung cancer diagnosis with quantitative DIC microscopy and a deep convolutional neural network. Biomedical optics express 7 31149379
2014 Delineation variable genotype/phenotype correlations of 6q27 terminal deletion derived from dic(6;18)(q27;p10). Molecular cytogenetics 7 25426168
2012 A novel fibrinogenase from Agkistrodon acutus venom protects against DIC via direct degradation of thrombosis and activation of protein C. Biochemical pharmacology 7 22728069
2005 Phase contrast and DIC illumination for AFM hybrids. Ultramicroscopy 7 15961230
1994 N-cyclohexyl-N'-isopropylcarbodiimide: a hybrid that combines the structural features of DCC and DIC. International journal of peptide and protein research 7 7896498
1986 Video microscopy of colloidal gold particles and immuno-gold labelled microtubules in improved rectified DIC and epi-illumination. Cell structure and function 7 3768966
1985 Analyses of factor XII, prekallikrein and kallikrein inhibitory capacity in patients with laboratory signs of DIC. Scandinavian journal of clinical and laboratory investigation. Supplementum 7 3867118
2024 Synthetic antimicrobial Nkl and Dic peptides are immunomodulatory but only Dic peptide can be therapeutic against nodavirus infection. Fish & shellfish immunology 6 39019125
2022 An evaluation of circulating activated TAFI in septic DIC: a case series and review of the literature. Thrombosis journal 6 35130927
2015 Perioperative blood loss and gastrointestinal tolerability of etoricoxib and diclofenac in total hip arthroplasty (ETO-DIC study): a single-center, prospective double-blinded randomized controlled trial. Current medical research and opinion 6 26414653
2006 A family case of fertile human 45,X,psu dic(15;Y) males. Cytogenetic and genome research 6 16974089

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