Affinage

SLC25A1

Tricarboxylate transport protein, mitochondrial · UniProt P53007

Length
311 aa
Mass
34.0 kDa
Annotated
2026-06-10
100 papers in source corpus 12 papers cited in narrative 12 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC25A1 encodes the inner mitochondrial membrane citrate carrier (CIC) that exports matrix citrate to the cytosol, where it is converted by ATP citrate lyase to acetyl-CoA, coupling mitochondrial metabolism to cytosolic lipogenic and acetylation programs (PMID:23561848, PMID:39881208). Recessive loss-of-function mutations abolish citrate efflux in patient fibroblasts and cause combined D-2- and L-2-hydroxyglutaric aciduria (PMID:23561848), and substrate-binding-site mutations (p.Arg198His) reduce respiratory capacity and impair transport activity (PMID:27306203). This carrier function is evolutionarily conserved: loss of the activity in Drosophila and human cells depletes global histone acetylation and produces chromosome breakage with ATR-dependent cell cycle arrest, establishing a role in genome integrity (PMID:19654186). The cytosolic citrate/acetyl-CoA pool generated by SLC25A1 fuels diverse downstream outputs: de novo lipogenesis and thermogenic gene control via Pgc1α acetylation in adipocytes (PMID:35585086), FSP1 acetylation at K168 that blocks its ubiquitin-mediated degradation and thereby suppresses ferroptosis (PMID:39881208), and inflammatory mediator production (PMID:25072865). SLC25A1 expression is regulated transcriptionally by NF-κB and STAT1 downstream of TNFα/IFNγ (PMID:25072865) and by oncogenic KRASG12D acting through GLI1, which binds the SLC25A1 promoter to drive lipid metabolism in pancreatic tumorigenesis (PMID:37695315), and post-translationally by IRAKM-mediated phosphorylation during IL-1β signaling (PMID:35585086). Through these axes SLC25A1 supports cancer stemness and therapy resistance (PMID:29651165), NASH and steatosis progression (PMID:31959914), and neuronal phenotypes when overexpressed (PMID:35203088).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1996 Medium

    Mapping the human citrate transporter gene located it within a disease-associated genomic interval, anchoring later functional and clinical interpretation.

    Evidence FISH and somatic cell hybrid panel mapping to chromosome 22q11.21

    PMID:8682495

    Open questions at the time
    • Mapping alone does not establish a causal role in any disease at the locus
    • No transport function tested
  2. 2009 High

    Established that citrate export by the carrier is required for global histone acetylation and chromosome integrity, linking a metabolite transporter to genome stability.

    Evidence Drosophila genetic loss-of-function plus siRNA knockdown in human fibroblasts with chromosome breakage, histone acetylation and cell cycle readouts

    PMID:19654186

    Open questions at the time
    • Molecular route from cytosolic citrate to specific histone acetylation marks not fully resolved
    • ATR activation mechanism downstream of acetylation loss undefined
  3. 2013 High

    Demonstrated that recessive loss-of-function mutations directly impair mitochondrial citrate efflux in patients, establishing SLC25A1 as a disease gene for combined D-2- and L-2-hydroxyglutaric aciduria.

    Evidence Stable isotope labeling and carrier protein analysis in patient fibroblasts across 12 individuals

    PMID:23561848

    Open questions at the time
    • Mechanism linking citrate efflux loss to accumulation of both 2-hydroxyglutarate enantiomers not fully defined
  4. 2014 Medium

    Connected SLC25A1 to inflammatory signaling by showing cytokine-driven transcriptional induction and a metabolic requirement for citrate/acetyl-CoA in producing inflammatory mediators.

    Evidence siRNA knockdown, cytokine stimulation, reporter assays and metabolite measurements (NO, prostaglandins, acetyl-CoA)

    PMID:25072865

    Open questions at the time
    • Direct NF-κB/STAT1 binding to the SLC25A1 promoter not shown
    • Single lab
  5. 2014 Medium

    Extended the disease spectrum by showing mutant carrier dysfunction underlies neuromuscular junction defects in a vertebrate model.

    Evidence In vitro mutant carrier assay and zebrafish knockdown with NMJ morphology analysis

    PMID:26870663

    Open questions at the time
    • Mechanism linking citrate transport loss to NMJ dysfunction unresolved
    • Knockdown not complemented by rescue
  6. 2016 Medium

    Pinpointed a substrate-binding-site residue as functionally required for transport, linking a missense mutation to bioenergetic consequences.

    Evidence Patient fibroblast respirometry, exome sequencing and citrate supplementation

    PMID:27306203

    Open questions at the time
    • Structural confirmation of the residue's role in substrate binding lacking
    • Single patient
  7. 2018 Medium

    Implicated SLC25A1 in maintaining mitochondrial citrate/redox balance to sustain cancer stemness and acquired therapy resistance.

    Evidence Pharmacological inhibition (CTPI-2), ROS and self-renewal assays, cisplatin/EGFR-inhibitor combinations in vitro, in vivo and patient-derived models

    PMID:29651165

    Open questions at the time
    • Off-target effects of CTPI-2 not excluded genetically
    • Single lab
  8. 2020 High

    Showed that SLC25A1 inhibition rewires hepatic lipogenic and gluconeogenic programs, defining a role in steatosis and NASH progression with tissue-specific dosage effects.

    Evidence CTPI-2 inhibition, global heterozygous and liver-specific conditional knockouts, gene expression and PPARγ/lipid synthesis assays

    PMID:31959914

    Open questions at the time
    • Direct biochemical link between citrate efflux and PPARγ modulation not isolated
  9. 2022 Medium

    Identified post-translational regulation of the carrier, with IRAKM binding and phosphorylating SLC25A1 to drive IL-1β-induced citrate export, lipogenesis and Pgc1α acetylation.

    Evidence Co-IP, phosphorylation assays, adipocyte-specific IRAKM knockout, IL-1β stimulation and citrate transport measurement

    PMID:35585086

    Open questions at the time
    • Phosphosite(s) on SLC25A1 not mapped
    • Reciprocal validation of interaction limited
    • Single lab
  10. 2022 Medium

    Demonstrated that SLC25A1 overexpression raises cytosolic citrate/acetyl-CoA and produces neurological and behavioral phenotypes, linking dosage to brain function.

    Evidence Neuron-specific transgenic mouse with metabolomics, acetyl-proteomics, synaptic morphology and behavioral testing

    PMID:35203088

    Open questions at the time
    • Specific acetylated substrates driving phenotypes not pinpointed
    • Single lab
  11. 2023 Medium

    Defined an oncogenic transcriptional axis in which KRASG12D-GLI1 directly induces SLC25A1 to boost cytosolic citrate and lipid metabolism for pancreatic tumorigenesis.

    Evidence GEMMs, ChIP of GLI1 at the SLC25A1 promoter, pharmacological inhibition, citrate and fatty acid measurements

    PMID:37695315

    Open questions at the time
    • Whether GLI1 acts alone or with cofactors at the promoter unclear
    • Single lab
  12. 2025 High

    Resolved a ferroptosis-suppressive mechanism whereby SLC25A1-derived acetyl-CoA sustains FSP1 acetylation at K168, blocking its ubiquitin-mediated degradation.

    Evidence CRISPR-Cas9 SLC screen, knockout and pharmacological inhibition, acetylation/ubiquitination assays and ferroptosis assays in vitro and in vivo

    PMID:39881208

    Open questions at the time
    • Stoichiometry of acetyl-CoA flux to FSP1 acetylation not quantified
    • KAT2B/HDAC3 recruitment mechanism to FSP1 undefined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the diverse cytosolic acetyl-CoA-dependent outputs (histone, FSP1, Pgc1α acetylation; lipogenesis; inflammation) are coordinated and prioritized in a given tissue or disease state remains unresolved.
  • No integrated model of substrate selectivity for the citrate/acetyl-CoA pool
  • Structural basis of transport and its regulation by phosphorylation not determined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 3 GO:0140104 molecular carrier activity 2
Localization
GO:0005739 mitochondrion 2
Pathway
R-HSA-1430728 Metabolism 3 R-HSA-382551 Transport of small molecules 2 R-HSA-4839726 Chromatin organization 1 R-HSA-5357801 Programmed Cell Death 1
Partners
IRAKM

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2014 SLC25A1 (mitochondrial citrate carrier, CIC) is transcriptionally induced by TNFα and IFNγ via NF-κB and STAT1 transcription factors, and the citrate exported from mitochondria via CIC and its downstream metabolic intermediate acetyl-CoA are required for TNFα- or IFNγ-induced nitric oxide and prostaglandin production. siRNA knockdown, cytokine stimulation, reporter assays, metabolite measurement (nitric oxide, prostaglandins), acetyl-CoA quantification Biochimica et biophysica acta Medium 25072865
2013 Recessive loss-of-function mutations in SLC25A1 cause impaired mitochondrial citrate efflux, demonstrated by stable isotope labeling and absence of carrier protein in patient fibroblasts, resulting in combined D-2- and L-2-hydroxyglutaric aciduria. Stable isotope labeling experiments, patient fibroblast studies, mutation analysis, SLC25A1 protein expression analysis American journal of human genetics High 23561848
2009 Loss of Sea/SLC25A1 (Drosophila ortholog) impairs citrate transport from mitochondria to cytosol, leading to extensive chromosome breakage in mitotic cells, ATR-dependent cell cycle arrest, and dramatic reduction of global histone acetylation. siRNA knockdown of SLC25A1 in human primary fibroblasts similarly causes chromosome breaks and histone acetylation defects, establishing an evolutionarily conserved role in chromosome integrity. Drosophila genetic mutation, siRNA knockdown in human fibroblasts, chromosomal breakage assay, histone acetylation measurement, cell cycle analysis Human molecular genetics High 19654186
2014 Mutations in SLC25A1 encoding the mitochondrial citrate carrier cause neuromuscular junction dysfunction; mutant SLC25A1 protein shows abnormal carrier function in vitro, and SLC25A1 knockdown in zebrafish mirrors human disease with clear neuromuscular junction abnormalities. In vitro carrier function assay of mutant protein, zebrafish SLC25A1 knockdown model, neuromuscular junction morphology analysis Journal of neuromuscular diseases Medium 26870663
2018 SLC25A1 maintains the mitochondrial pool of citrate and redox balance in lung cancer stem cells; its inhibition leads to ROS build-up and inhibition of self-renewal. Resistance to cisplatin or EGFR inhibitors is acquired through SLC25A1-mediated upregulation of mitochondrial activity and induction of stemness. SLC25A1 inhibition (CTPI-2), ROS measurement, self-renewal assays, cisplatin/EGFR inhibitor combination studies in vitro and in animal models, patient-derived tumor models Cell death and differentiation Medium 29651165
2020 Slc25a1 inhibition with CTPI-2 halts steatosis and prevents NASH progression; mechanistically, through citrate-dependent activities, Slc25a1 inhibition rewires the lipogenic program, blunts PPARγ signaling, and inhibits gluconeogenic gene expression. Liver-targeted Slc25a1 knockout reveals tissue-specific and dose-dependent functions. Pharmacological inhibition (CTPI-2), global heterozygous knockout, liver-targeted conditional knockout, gene expression analysis, PPARγ signaling assays, lipid synthesis measurement Cell death and differentiation High 31959914
2022 IRAKM interacts with and phosphorylates the mitochondrial citrate carrier Slc25a1 to promote IL-1β-induced mitochondrial citrate transport to the cytosol and de novo lipogenesis in adipocytes. IRAKM also mediates Pgc1α acetylation via this axis to regulate thermogenic gene expression. Co-immunoprecipitation, phosphorylation assay, adipocyte-specific IRAKM knockout, IL-1β stimulation, citrate transport measurement, lipogenesis assay Nature communications Medium 35585086
2025 SLC25A1 drives citrate export from mitochondria to the cytosol where ATP citrate lyase (ACLY) converts it to acetyl-CoA; this acetyl-CoA sustains FSP1 acetylation at K168 (by KAT2B, reversed by HDAC3), preventing FSP1 degradation via K29-linked ubiquitin chains. Pharmacological inhibition of SLC25A1 enhances cancer cell susceptibility to ferroptosis in vitro and in vivo. CRISPR-Cas9 screen of SLC superfamily, genetic knockout, pharmacological inhibition, acetylation assays, ubiquitination assays, ferroptosis assays in vitro and in vivo The EMBO journal High 39881208
2023 Oncogenic KRASG12D upregulates SLC25A1 transcription via GLI1, which directly binds the SLC25A1 promoter; enhanced SLC25A1 expression increases cytosolic citrate, fatty acids, and key lipid metabolism enzymes to drive pancreatic tumorigenesis. High-fat diet further stimulates this KRASG12D-GLI1-SLC25A1 axis. Genetically engineered mouse models, ChIP (GLI1 binding to SLC25A1 promoter), pharmacological inhibition of SLC25A1 and GLI1, citrate and fatty acid measurements, pancreatic cancer cell studies Cancer research Medium 37695315
2022 Overexpression of SLC25A1 in mouse forebrain neurons increases steady-state levels of cytosolic citrate and acetyl-CoA, causes disrupted white matter integrity, altered synaptic plasticity and morphology, and produces autistic-like behavior. SLC25A1 upregulation maintains cytosolic acetyl-CoA by supplying citrate for ACLY-mediated conversion. Neuron-specific SLC25A1 transgenic mouse, behavioral testing, metabolomics (citrate, acetyl-CoA), proteomics and acetyl-proteomics, synaptic morphology analysis Brain : a journal of neurology Medium 35203088
1996 The human mitochondrial citrate transporter gene (SLC25A1, referred to as SLC20A3 at the time) maps to chromosome band 22q11.21 in a region associated with DiGeorge syndrome, velo-cardio-facial syndrome, and schizophrenia. Human-hamster somatic cell hybrid panel, fluorescence in situ hybridization (FISH) Human genetics Medium 8682495
2016 A homozygous missense mutation in SLC25A1 (p.Arg198His) putatively situated within substrate-binding site I of the carrier causes reduced mitochondrial spare respiratory capacity, increased glycolytic flux, and reduced cell survival, establishing a functional requirement for this residue in CIC transport activity. Patient fibroblast functional studies, mitochondrial respirometry, exome sequencing, citrate supplementation experiments JIMD reports Medium 27306203

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 The metabolic enzyme CTP synthase forms cytoskeletal filaments. Nature cell biology 231 20639870
1997 CTP:phosphocholine cytidylyltransferase. Biochimica et biophysica acta 186 9370319
2014 CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation. Nature 178 24870241
1984 Relationships among Ara-CTP pools, formation of (Ara-C)DNA, and cytotoxicity of human leukemic cells. Blood 175 6587917
2010 Intracellular compartmentation of CTP synthase in Drosophila. Journal of genetics and genomics = Yi chuan xue bao 173 20513629
2000 Regulation of CTP:phosphocholine cytidylyltransferase by amphitropism and relocalization. Trends in biochemical sciences 172 10973058
2011 Induction of cytoplasmic rods and rings structures by inhibition of the CTP and GTP synthetic pathway in mammalian cells. PloS one 170 22220215
2014 A key role of the mitochondrial citrate carrier (SLC25A1) in TNFα- and IFNγ-triggered inflammation. Biochimica et biophysica acta 166 25072865
1990 Cloning and expression of rat liver CTP: phosphocholine cytidylyltransferase: an amphipathic protein that controls phosphatidylcholine synthesis. Proceedings of the National Academy of Sciences of the United States of America 149 2166941
2017 Human CTP synthase filament structure reveals the active enzyme conformation. Nature structural & molecular biology 141 28459447
2019 ParB-type DNA Segregation Proteins Are CTP-Dependent Molecular Switches. Cell 128 31835030
2015 CTP:phosphocholine cytidylyltransferase: Function, regulation, and structure of an amphitropic enzyme required for membrane biogenesis. Progress in lipid research 118 26165797
2013 Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria. American journal of human genetics 115 23561848
2018 The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer. Cell death and differentiation 114 29651165
1998 Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase. The Journal of biological chemistry 113 9593753
2002 Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP. Cell 107 12526808
2019 Self-organization of parS centromeres by the ParB CTP hydrolase. Science (New York, N.Y.) 106 31649139
1998 Effect of CTP synthetase regulation by CTP on phospholipid synthesis in Saccharomyces cerevisiae. The Journal of biological chemistry 104 9668079
2020 Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Cell death and differentiation 100 31959914
2007 Developmental and metabolic effects of disruption of the mouse CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2). Molecular and cellular biology 96 17325045
2007 Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis: the role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2). Biochemistry and cell biology = Biochimie et biologie cellulaire 94 17612623
1999 Interactions among pathways for phosphatidylcholine metabolism, CTP synthesis and secretion through the Golgi apparatus. Trends in biochemical sciences 89 10322420
2008 Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase. The Journal of biological chemistry 81 18458076
2003 Gene structure, expression and identification of a new CTP:phosphocholine cytidylyltransferase beta isoform. Biochimica et biophysica acta 80 12842190
2014 Common regulatory control of CTP synthase enzyme activity and filament formation. Molecular biology of the cell 78 24920825
1987 CTP:phosphorylcholine cytidylyltransferase from rat liver. Isolation and characterization of the catalytic subunit. The Journal of biological chemistry 76 3036843
2014 CTP synthase forms cytoophidia in the cytoplasm and nucleus. Experimental cell research 75 24503052
2000 Tumor necrosis factor-alpha inhibits expression of CTP:phosphocholine cytidylyltransferase. The Journal of biological chemistry 74 10734122
2014 Mutations in the Mitochondrial Citrate Carrier SLC25A1 are Associated with Impaired Neuromuscular Transmission. Journal of neuromuscular diseases 71 26870663
2008 CTP synthetase and its role in phospholipid synthesis in the yeast Saccharomyces cerevisiae. Progress in lipid research 68 18439916
2018 The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia. Frontiers in oncology 67 29888201
2014 Ack kinase regulates CTP synthase filaments during Drosophila oogenesis. EMBO reports 64 25223282
1995 The association of lipid activators with the amphipathic helical domain of CTP:phosphocholine cytidylyltransferase accelerates catalysis by increasing the affinity of the enzyme for CTP. The Journal of biological chemistry 64 7592590
2016 The Interplay between Myc and CTP Synthase in Drosophila. PLoS genetics 63 26889675
1993 Expression, purification, and characterization of CTP:glycerol-3-phosphate cytidylyltransferase from Bacillus subtilis. The Journal of biological chemistry 63 8393871
2001 CTP:phosphocholine cytidylyltransferase alpha is a cytosolic protein in pulmonary epithelial cells and tissues. The Journal of biological chemistry 58 11583989
2011 An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts. Developmental cell 56 21920316
1996 Isolation and characterization of ECT1 gene encoding CTP: phosphoethanolamine cytidylyltransferase of Saccharomyces cerevisiae. Journal of biochemistry 56 8982874
1995 Phosphorylation of CTP synthetase from Saccharomyces cerevisiae by protein kinase C. The Journal of biological chemistry 55 7797479
1999 CTP:phosphocholine cytidylyltransferase: insights into regulatory mechanisms and novel functions. Biochemical and biophysical research communications 54 10208837
1991 Cloning, sequencing and characterization of the Saccharomyces cerevisiae URA7 gene encoding CTP synthetase. Molecular & general genetics : MGG 54 1753946
2021 SLC25A1 promotes tumor growth and survival by reprogramming energy metabolism in colorectal cancer. Cell death & disease 53 34839347
2009 A conserved role for the mitochondrial citrate transporter Sea/SLC25A1 in the maintenance of chromosome integrity. Human molecular genetics 53 19654186
2015 Nuclear-localized CTP:phosphocholine cytidylyltransferase α regulates phosphatidylcholine synthesis required for lipid droplet biogenesis. Molecular biology of the cell 52 26108622
2002 Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis. Molecular and cellular biology 51 12052891
1998 Nucleotide-dependent tetramerization of CTP synthetase from Saccharomyces cerevisiae. The Journal of biological chemistry 51 9632643
1996 Phosphorylation and regulation of CTP synthetase from Saccharomyces cerevisiae by protein kinase A. The Journal of biological chemistry 51 8910520
2013 Only one isoform of Drosophila melanogaster CTP synthase forms the cytoophidium. PLoS genetics 50 23459760
2021 Relief of ParB autoinhibition by parS DNA catalysis and recycling of ParB by CTP hydrolysis promote bacterial centromere assembly. Science advances 47 34613769
2019 Drosophila CTP synthase can form distinct substrate- and product-bound filaments. Journal of genetics and genomics = Yi chuan xue bao 47 31902586
2021 CTP promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional diffusion from parS. eLife 46 34250901
1996 Regulation of yeast CTP synthetase activity by protein kinase C. The Journal of biological chemistry 45 8626655
2021 A CTP-dependent gating mechanism enables ParB spreading on DNA. eLife 44 34397383
1994 Purification and characterization of CTP synthetase, the product of the URA7 gene in Saccharomyces cerevisiae. Biochemistry 43 8075080
1994 Primary structure and expression of a human CTP:phosphocholine cytidylyltransferase. Biochimica et biophysica acta 42 7918629
2015 Regulation of CTP Synthase Filament Formation During DNA Endoreplication in Drosophila. Genetics 41 26482795
2021 CTP-controlled liquid-liquid phase separation of ParB. Journal of molecular biology 40 34902429
2020 CTP synthase forms cytoophidia in archaea. Journal of genetics and genomics = Yi chuan xue bao 40 32507415
2003 Enhanced expression and activation of CTP:phosphocholine cytidylyltransferase beta2 during neurite outgrowth. The Journal of biological chemistry 40 12928431
2001 CTP:phosphocholine cytidylyltransferase, a new sterol- and SREBP-responsive gene. Journal of lipid research 36 11483628
2003 Phosphorylation of Saccharomyces cerevisiae CTP synthetase at Ser424 by protein kinases A and C regulates phosphatidylcholine synthesis by the CDP-choline pathway. The Journal of biological chemistry 35 12709422
2006 Human dolichol kinase, a polytopic endoplasmic reticulum membrane protein with a cytoplasmically oriented CTP-binding site. The Journal of biological chemistry 34 16923818
1999 Identification of Ser424 as the protein kinase A phosphorylation site in CTP synthetase from Saccharomyces cerevisiae. Biochemistry 34 10393561
2018 Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase. Cell reports 33 30184506
2005 Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A. The Journal of biological chemistry 33 16179339
1978 Partial purification and properties of CTP:phosphatidic acid cytidylyltransferase from membranes of Escherichia coli. Journal of bacteriology 32 30751
2008 Stimulation of the human CTP:phosphoethanolamine cytidylyltransferase gene by early growth response protein 1. Journal of lipid research 31 18583706
2021 CTP and parS coordinate ParB partition complex dynamics and ParA-ATPase activation for ParABS-mediated DNA partitioning. eLife 30 34286695
1995 Cloning and expression of the Chlamydia trachomatis gene for CTP synthetase. The Journal of biological chemistry 30 7713886
2007 Calmodulin binds and stabilizes the regulatory enzyme, CTP: phosphocholine cytidylyltransferase. The Journal of biological chemistry 29 17804406
1984 Trifluoperazine and chlorpromazine inhibit phosphatidylcholine biosynthesis and CTP:phosphocholine cytidylyltransferase in HeLa cells. Biochimica et biophysica acta 28 6089904
2014 Combined D2-/L2-hydroxyglutaric aciduria (SLC25A1 deficiency): clinical course and effects of citrate treatment. Journal of inherited metabolic disease 27 24687295
2021 CTP regulates membrane-binding activity of the nucleoid occlusion protein Noc. Molecular cell 26 34270916
1997 CTP:phosphoethanolamine cytidylyltransferase. Biochimica et biophysica acta 26 9370320
2023 Oncogenic KRASG12D Reprograms Lipid Metabolism by Upregulating SLC25A1 to Drive Pancreatic Tumorigenesis. Cancer research 25 37695315
1995 Cytidine triphosphate (CTP) synthetase activity during cell cycle progression in normal and malignant T-lymphocytic cells. European journal of cancer (Oxford, England : 1990) 25 7695960
2023 A novel SLC25A1 inhibitor, parthenolide, suppresses the growth and stemness of liver cancer stem cells with metabolic vulnerability. Cell death discovery 24 37741815
2005 Interdomain and membrane interactions of CTP:phosphocholine cytidylyltransferase revealed via limited proteolysis and mass spectrometry. The Journal of biological chemistry 24 15713672
2025 Metabolic reprogramming signature predicts immunotherapy efficacy in lung adenocarcinoma: Targeting SLC25A1 to overcome immune resistance. Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 23 41536497
2025 SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation. The EMBO journal 22 39881208
2019 ADGRL4/ELTD1 Silencing in Endothelial Cells Induces ACLY and SLC25A1 and Alters the Cellular Metabolic Profile. Metabolites 22 31775252
2004 Expression of the pyrG gene determines the pool sizes of CTP and dCTP in Lactococcus lactis. European journal of biochemistry 22 15182359
2001 CTP:phosphocholine cytidylyltransferase inhibition by ceramide via PKC-alpha, p38 MAPK, cPLA2, and 5-lipoxygenase. American journal of physiology. Lung cellular and molecular physiology 22 11404253
2019 Congenital myasthenic syndrome with mild intellectual disability caused by a recurrent SLC25A1 variant. European journal of human genetics : EJHG 21 31527857
2015 Male-Specific Cardiac Dysfunction in CTP:Phosphoethanolamine Cytidylyltransferase (Pcyt2)-Deficient Mice. Molecular and cellular biology 21 25986609
2010 Complementation of the metabolic defect in CTP:phosphoethanolamine cytidylyltransferase (Pcyt2)-deficient primary hepatocytes. Metabolism: clinical and experimental 21 20427062
1996 The human mitochondrial citrate transporter gene (SLC20A3) maps to chromosome band 22q11 within a region implicated in DiGeorge syndrome, velo-cardio-facial syndrome and schizophrenia. Human genetics 21 8682495
1996 Chlamydia trachomatis CTP synthetase: molecular characterization and developmental regulation of expression. Molecular microbiology 21 8951811
2017 Critical roles of CTP synthase N-terminal in cytoophidium assembly. Experimental cell research 20 28342900
2012 Mechanism of hypertriglyceridemia in CTP:phosphoethanolamine cytidylyltransferase-deficient mice. Journal of lipid research 20 22764088
1999 Cloning and expression of CTP:phosphoethanolamine cytidylyltransferase cDNA from rat liver. The Biochemical journal 20 10493918
2023 Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation. Life science alliance 19 37348953
2022 Increased expression of SLC25A1/CIC causes an autistic-like phenotype with altered neuron morphology. Brain : a journal of neurology 19 35203088
2022 IL-1R-IRAKM-Slc25a1 signaling axis reprograms lipogenesis in adipocytes to promote diet-induced obesity in mice. Nature communications 19 35585086
2016 Severe Neonatal Presentation of Mitochondrial Citrate Carrier (SLC25A1) Deficiency. JIMD reports 19 27306203
2016 Inhibition of Escherichia coli CTP Synthetase by NADH and Other Nicotinamides and Their Mutual Interactions with CTP and GTP. Biochemistry 19 27571563
2014 Isoform-specific and protein kinase C-mediated regulation of CTP:phosphoethanolamine cytidylyltransferase phosphorylation. The Journal of biological chemistry 19 24519946
2006 Phosphorylation of human CTP synthetase 1 by protein kinase A: identification of Thr455 as a major site of phosphorylation. The Journal of biological chemistry 19 17189248
2023 CTP switches in ParABS-mediated bacterial chromosome segregation and beyond. Current opinion in microbiology 18 36871427
2009 CTP:phosphocholine cytidylyltransferase alpha is required for B-cell proliferation and class switch recombination. The Journal of biological chemistry 18 19139091

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