Affinage

SLC10A1

Hepatic sodium/bile acid cotransporter · UniProt Q14973

Length
349 aa
Mass
38.1 kDa
Annotated
2026-06-10
100 papers in source corpus 38 papers cited in narrative 38 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC10A1 (NTCP) is the principal sodium-dependent transporter that imports conjugated bile acids into hepatocytes, functioning at the rate-limiting basolateral uptake step of the enterohepatic bile salt cycle (PMID:16474011, PMID:24867799). It transports taurine and glycine conjugates in preference to unconjugated bile salts, and when reconstituted with the apical exporter BSEP it reconstitutes vectorial basolateral-to-apical bile acid flux across polarized epithelium (PMID:16474011). Cryo-EM structures show a transmembrane tunnel forming the substrate translocation route; residue 267 lies within a region critical for bile acid recognition, where substitutions act as a graded rheostat over transport kinetics and substrate selectivity while sparing the non-bile-acid substrate estrone sulfate (PMID:35580629, PMID:14660639, PMID:33168628). NTCP activity at the plasma membrane is set by regulated trafficking: PI3K/PKB(Akt) signaling and PP2B(calcineurin)-mediated dephosphorylation of Ser-226 promote membrane insertion, PKCζ drives microtubule-based motility of NTCP recycling vesicles, a dileucine motif and PKC-triggered clathrin-dependent endocytosis remove it, and misfolded NTCP is cleared by ubiquitin-proteasome ERAD (PMID:16027164, PMID:12065290, PMID:12034724, PMID:16734659, PMID:24008362, PMID:16218878). N-linked glycosylation is required for plasma membrane targeting, and S-nitrosylation of cysteines non-competitively inhibits transport (PMID:28125599, PMID:21109590). Transcription of the gene is controlled by HNF1α, HNF4α, RXR:RAR and RAR, and is repressed in cholestasis through bile-acid/FXR-dependent loss of these activators and by inflammatory JNK signaling (PMID:14701722, PMID:25550158, PMID:16002565, PMID:12105223). Independently of its metabolic role, NTCP is the high-affinity hepatocyte entry receptor for HBV and HDV: the myristoylated preS1 domain of the HBV large surface protein binds the extracellular mouth of the transport tunnel in direct competition with bile acid substrate, and viral internalization requires EGFR-dependent NTCP oligomerization followed by clathrin-mediated endocytosis (PMID:35580629, PMID:24342612, PMID:24845614, PMID:34613794, PMID:32216005). Homozygous loss-of-function mutation (R252H) causes NTCP deficiency, an inborn error of bile salt metabolism with markedly reduced bile acid uptake (PMID:24867799).

Mechanistic history

Synthesis pass · year-by-year structured walk · 20 steps
  1. 1999 High

    Establishing that NTCP intrinsically carries out sodium-dependent bile acid transport defined its core molecular activity independent of cellular context.

    Evidence Functional expression of two mouse Ntcp splice isoforms in Xenopus oocytes with saturable taurocholate uptake

    PMID:10209268

    Open questions at the time
    • Oocyte system does not address polarized hepatocyte localization
    • Did not define substrate-recognition residues
  2. 2002 High

    Identifying PP2B-mediated dephosphorylation and PI3K/PKB signaling as drivers of NTCP membrane translocation showed that transporter activity is acutely controlled by regulated trafficking rather than expression alone.

    Evidence PP2B inhibition and immunoprecipitated-NTCP dephosphorylation in rat hepatocytes; dominant-negative/constitutively active PKB with translocation and uptake readouts

    PMID:12034724 PMID:12065290

    Open questions at the time
    • Did not identify the target phosphosite
    • Upstream stimulus integration unresolved at this stage
  3. 2002 High

    Showing that inflammatory signaling represses Ntcp transcription via JNK-phosphorylated RXR linked NTCP downregulation to the hepatic response to cytokines and cholestasis.

    Evidence Ntcp promoter luciferase, dominant-negative JNK, EMSA in primary rat hepatocytes; SHP-1 induction timing in bile-duct-ligated mice

    PMID:11751172 PMID:12105223

    Open questions at the time
    • SHP-1 link was temporal correlation only
    • Did not separate cytokine vs bile-acid contributions
  4. 2003 High

    Mapping species-specific and conserved transcription factor inputs (HNF1α, HNF4α, RXR/RAR, HNF3β, C/EBPβ) defined the regulatory architecture of the NTCP promoter.

    Evidence Cross-species luciferase reporter and EMSA assays in Huh7 cells

    PMID:14701722

    Open questions at the time
    • Species divergence complicates extrapolation to human regulation
    • In vivo occupancy not established here
  5. 2003 High

    Demonstrating that the S267F polymorphism abolishes bile acid uptake while sparing estrone sulfate and membrane expression localized substrate recognition to a discrete region.

    Evidence Variant transport assays with multiple substrates plus cell-surface biotinylation in HepG2/transfected cells

    PMID:14660639

    Open questions at the time
    • Atomic basis of substrate selectivity not yet resolved
    • Physiological consequence in carriers not addressed
  6. 2005 High

    Pinpointing Ser-226 as the cAMP-regulated phosphosite governing membrane retention connected the kinase/phosphatase circuitry to a defined molecular switch.

    Evidence 32P labeling, clostripain mapping, S226A mutagenesis with uptake and surface expression in HuH-7 cells

    PMID:16027164

    Open questions at the time
    • Kinase phosphorylating Ser-226 not directly identified
    • Interplay with the dileucine endocytosis motif not yet defined
  7. 2005 High

    Establishing FXR-dependent, bile-acid-mediated (not cytokine-mediated) repression of Ntcp in obstructive cholestasis resolved the dominant in vivo control mechanism.

    Evidence FXR knockout mice, bile duct ligation, cholic acid feeding, LPS, EMSA; plus Kupffer-cell depletion and cytokine neutralization controls

    PMID:15629514 PMID:15723437 PMID:16002565

    Open questions at the time
    • FXR-to-HNF axis intermediate steps incomplete
    • LPS/inflammatory repression operates by a distinct, less-defined pathway
  8. 2005 High

    Identifying ERAD/ubiquitin-proteasome clearance of misfolded NTCP defined the protein's quality-control degradation route.

    Evidence Proteasome inhibitors, polyubiquitination assay, glycosylation analysis and MTOC aggresome colocalization in HepG2 cells

    PMID:16218878

    Open questions at the time
    • Specific E3 ligase not identified
    • Relationship to surface-pool turnover unresolved
  9. 2006 High

    Reconstituting vectorial bile acid transport with NTCP and BSEP, and defining PKCζ-dependent vesicular motility, established NTCP's role in transcellular flux and its trafficking machinery.

    Evidence Double-transfected polarized LLC-PK1 transcellular flux; live imaging of NTCP-GFP vesicles with PKCζ inhibition and motor/endosome markers

    PMID:16474011 PMID:16734659

    Open questions at the time
    • Coupling of motility to specific signaling stimuli incomplete
    • Kinesin/dynein switching control not defined
  10. 2010 High

    Showing S-nitrosylation of NTCP cysteines causes reversible non-competitive transport inhibition added a redox-based post-translational control layer.

    Evidence Biotin switch assay, kinetic uptake, surface biotinylation, DTT rescue in HuH-NTCP cells

    PMID:21109590

    Open questions at the time
    • Modified cysteine residues not individually mapped
    • Physiological NO source not defined
  11. 2013 High

    Defining a dileucine motif with dual endocytosis/membrane-targeting roles and clathrin-dependent PKC-triggered internalization completed the retrieval arm of NTCP trafficking.

    Evidence Mutagenesis of dileucine motif and Thr225/Ser226, flow cytometry, immunofluorescence in HepG2 cells

    PMID:24008362

    Open questions at the time
    • Adaptor recognizing the motif not identified
    • Reconciliation with Ser-226 dephosphorylation switch incomplete
  12. 2013 High

    Confirming NTCP as the functional HBV entry receptor and mapping cyclosporin A action to the preS1-binding site established the receptor function and its overlap with transport.

    Evidence NTCP overexpression/knockdown HBV infection assays; cyclosporin A inhibition, preS1 binding, and transport-competent/binding-deficient variants

    PMID:24295872 PMID:24342612

    Open questions at the time
    • Post-attachment internalization steps not yet defined
    • Co-receptor requirements unresolved at this stage
  13. 2014 High

    Demonstrating reciprocal competition between preS1 and bile acids, and that R252H loss-of-function causes human NTCP deficiency, tied the viral and metabolic functions to a shared site and proved NTCP's role as the main hepatic bile salt importer.

    Evidence Reciprocal inhibition kinetics in primary hepatocytes and cell lines; patient sequencing with uptake assay and surface localization

    PMID:24845614 PMID:24867799

    Open questions at the time
    • Spectrum of clinical phenotypes in deficiency not detailed
    • Quantitative overlap of viral vs substrate sites not structurally resolved here
  14. 2014 Medium

    Identifying RAR control of the human NTCP promoter linked nuclear receptor signaling to both transporter expression and HBV permissiveness.

    Evidence Promoter luciferase, RAR ChIP, RAR antagonists with HBV infection in HepG2-hNTCP

    PMID:25550158

    Open questions at the time
    • Single lab; in vivo relevance not established
    • Endogenous RAR ligand context unclear
  15. 2017 High

    Establishing that N-linked glycosylation at N5/N11 is required for membrane trafficking and HBV infection clarified a biosynthetic prerequisite for both functions.

    Evidence Glycosylation-site mutagenesis, surface biotinylation, lysosomal degradation and HBV/uptake assays in HepG2 cells

    PMID:28125599

    Open questions at the time
    • Glycan-dependent chaperone interactions not identified
    • Effect on oligomerization not tested
  16. 2020 High

    Systematic saturation mutagenesis at position 267 reframed substrate recognition as a tunable rheostat coupling stability/expression and substrate-specific kinetics.

    Evidence All-20-amino-acid substitution with three substrates, surface expression, and Rosetta stability modeling; prior A64T/S267F variant kinetics

    PMID:21341987 PMID:33168628

    Open questions at the time
    • Structural rationalization of rheostat behavior incomplete
    • Population-level pharmacogenetic impact not assessed
  17. 2021 High

    Resolving that NTCP oligomerization downstream of EGFR is required for HBV internalization, and defining clathrin-dependent uptake, established the ordered post-attachment entry mechanism.

    Evidence SPR, F274A mutagenesis, CoIP, oligomerization assays with troglitazone; clathrin/AP-2/dynamin-2 knockdown and EM in HepG2-NTCP

    PMID:32216005 PMID:34613794

    Open questions at the time
    • Stoichiometry of the oligomer not defined
    • How EGFR engagement triggers oligomerization unresolved
  18. 2022 High

    Cryo-EM structures of NTCP, alone and with preS1, provided the atomic framework for the bile acid transport tunnel and the structural basis of viral receptor engagement.

    Evidence Cryo-EM of human/bovine/rat NTCP and antibody/preS1 complexes with mutation and transport assays

    PMID:35580629 PMID:35580630

    Open questions at the time
    • Substrate-bound and intermediate conformational states not captured
    • Sodium coupling mechanism not fully detailed
  19. 2022 Medium

    Identifying IFITM3 as an NTCP interaction partner facilitating a post-attachment HBV/HDV entry step expanded the receptor complex beyond NTCP itself.

    Evidence Membrane yeast-two-hybrid, CoIP, IFITM3 knockdown with HBV/HDV infection and preS1 binding in HuH7 and primary hepatocytes

    PMID:35458456

    Open questions at the time
    • Single lab; mechanism of IFITM3 action at the entry step undefined
    • Direct vs indirect interaction not fully resolved
  20. 2024 High

    The bulevirtide-bound NTCP structure explained how the therapeutic peptide plugs the transport tunnel and underlies HBV/HDV host specificity.

    Evidence Cryo-EM of BLV-bound human NTCP; prior high-affinity, long-lived binding/turnover measurements

    PMID:32039379 PMID:38509088

    Open questions at the time
    • In vivo pharmacodynamic linkage to NTCP turnover only correlative
    • Resistance mechanisms not addressed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How NTCP's bile-acid transport function mechanistically intersects with broader physiology—innate antiviral immunity, cell-cycle control, and systemic metabolism—remains incompletely defined.
  • Causal chain from bile-acid transport to ISG/IFITM3 repression not fully mapped
  • Mechanism coupling NTCP expression to G0/G1 arrest unresolved
  • Tissue-level metabolic effects of NTCP loss in humans not characterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 5 GO:0001618 virus receptor activity 4 GO:0140104 molecular carrier activity 2 GO:0038024 cargo receptor activity 1
Localization
GO:0005886 plasma membrane 5 GO:0005768 endosome 2 GO:0005783 endoplasmic reticulum 2 GO:0005815 microtubule organizing center 1
Pathway
R-HSA-74160 Gene expression (Transcription) 4 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 3 R-HSA-382551 Transport of small molecules 3 R-HSA-1430728 Metabolism 2
Partners
BSEPEGFRIFITM3OATP1B3

Evidence

Reading pass · 38 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2022 Cryo-EM structures of human, bovine, and rat NTCPs in the apo state reveal a tunnel across the membrane and a possible transport route for the bile acid substrate. The structure of human NTCP in complex with the myristoylated preS1 domain of the HBV large surface protein, together with mutation and transport assays, shows that preS1 and the bile acid substrate compete for the extracellular opening of the tunnel, establishing the binding mode for viral entry. Cryo-electron microscopy, mutation assays, transport assays Nature High 35580629
2022 Cryo-EM structure of NTCP bound to an antibody shows the transporter lacks the first transmembrane helix found in other SLC10 proteins and has an N-terminus exposed on the extracellular face. Comparison with related proteins indicates a common mechanism of bile acid transport, and an additional pocket formed by residues known to interact with preS1 was identified. Cryo-electron microscopy, structural comparison Nature High 35580630
2024 Cryo-EM structure of bulevirtide (BLV/Myrcludex B)-bound human NTCP reveals BLV forms two domains: a plug lodged in the bile salt transport tunnel of NTCP and a string covering the extracellular surface, with the N-terminal myristoyl group interacting with the lipid-exposed surface of NTCP. This structure explains how BLV blocks bile salt transport and provides a structural basis for HBV/HDV host specificity. Cryo-electron microscopy Nature communications High 38509088
2013 NTCP (SLC10A1) was confirmed as the functional HBV entry receptor: HepG2 cells engineered to overexpress human NTCP became susceptible to HBV infection, and knockdown of NTCP blocked infection. Compounds that inhibit NTCP transporter activity (including cyclosporin A and oxysterols) also blocked HBV infection, linking bile acid transport function to viral entry. NTCP overexpression in HepG2 cells, siRNA knockdown, HBV infection assay, inhibitor studies Biochemical and biophysical research communications High 24342612
2013 Cyclosporin A inhibits HBV and HDV entry by directly interfering with NTCP receptor function in a cyclophilin-independent manner. Binding of the HBVpreS1 domain to NTCP was blocked by cyclosporin A, and an NTCP variant deficient in HBVpreS1 binding but competent for bile salt transport was resistant to cyclosporin A, mapping the interaction site to the preS1-binding domain on NTCP. HepaRG cells and NTCP-expressing hepatoma cell lines, taurocholate uptake assay, HBVpreS1 binding assay, cyclophilin siRNA, NTCP variant studies Journal of hepatology High 24295872
2014 The myristoylated preS1 domain of HBV inhibits bile acid transport by NTCP, and inversely, bile acid conjugates (taurine/glycine conjugates of cholic acid and ursodeoxycholic acid) inhibit HBV infection in a concentration-dependent manner. NTCP expression, transport function, preS1 peptide binding, and HBV infection follow comparable kinetics, establishing direct functional overlap between the bile acid transport site and the HBV receptor site. Bile acid transport assays, HBV infection assays, myr-preS1 peptide binding in primary hepatocytes and NTCP-transfected cells Journal of hepatology High 24845614
2005 Dephosphorylation of Ser-226 in the third cytoplasmic loop of NTCP facilitates plasma membrane retention. Mutation of Ser-226 to Ala decreased NTCP phosphorylation by 30% and increased taurocholate uptake and plasma membrane retention 2.5–3.2-fold; cAMP failed to further increase translocation of S226A-NTCP, establishing Ser-226 as the cAMP-regulated phosphorylation site controlling NTCP plasma membrane localization. Metabolic [32P] labeling, clostripain digestion, site-directed mutagenesis, taurocholate uptake assay, cell surface expression in transfected HuH-7 cells The Journal of biological chemistry High 16027164
2002 PP2B (calcineurin), a Ca2+/calmodulin-dependent phosphatase, mediates cAMP-induced dephosphorylation and translocation of NTCP to the plasma membrane. The PP2B inhibitor cypermethrin reversed cAMP-mediated NTCP dephosphorylation and translocation, and PP2B directly dephosphorylated immunoprecipitated NTCP from control but not cAMP-treated hepatocytes. PP2B inhibitors (cypermethrin, FK-506), taurocholate uptake assay, NTCP immunoprecipitation, PP2B activity assay in isolated rat hepatocytes American journal of physiology. Gastrointestinal and liver physiology High 12065290
2002 Protein kinase B (PKB/Akt) mediates cAMP- and cell swelling-stimulated Na+/taurocholate cotransport and NTCP translocation to the plasma membrane via the PI3K/PKB signaling pathway. Dominant-negative PKB blocked cAMP- and swelling-induced increases in TC uptake and NTCP translocation, while constitutively active PKB increased both. Dominant-negative and constitutively active PKB transfection, taurocholate uptake assay, NTCP translocation assay in HuH-Ntcp cells The Journal of biological chemistry High 12034724
2006 NTCP-containing vesicles are present on intracellular recycling endosomes and move bidirectionally on microtubules using kinesin-1 and dynein motors. PKCζ is specifically required for microtubule-based motility of NTCP vesicles: PI(3,4,5)P3 activates PKCζ and enhances motility, while specific inhibition of PKCζ blocks motility of NTCP-containing vesicles but not late vesicles. In vitro and whole-cell immunofluorescence microscopy, live-cell imaging of NTCP-GFP, PKCζ inhibitor, colocalization with endosomal markers Traffic (Copenhagen, Denmark) High 16734659
2005 Rat Ntcp/human NTCP is degraded by the ubiquitin-proteasome system via ER-associated degradation (ERAD). Proteasome inhibition led to accumulation of core-glycosylated (ER-resident) intracellular NTCP that co-localized with ubiquitin at the microtubule organization center as polyubiquitinated aggresomes. Proteasome inhibitors (MG-132, lactacystin), co-localization studies, polyubiquitination assay, glycosylation analysis in stably transfected HepG2 cells Biological chemistry High 16218878
2002 Interleukin-1β suppresses Ntcp gene expression via a JNK-dependent mechanism: JNK phosphorylates RXR, reducing nuclear RXR:RAR binding activity and thereby decreasing RXR:RAR-mediated transactivation of the Ntcp promoter. JNK inhibition by curcumin or dominant-negative JNK completely blocked IL-1β-mediated suppression, while ERK and p38 inhibitors had no effect. Ntcp promoter luciferase assays, JNK expression plasmids (dominant-negative and wild-type), pharmacological inhibitors, EMSA, primary rat hepatocytes The Journal of biological chemistry High 12105223
2003 HNF1α, HNF4α, and RXRα/RARα activate the rat Ntcp promoter but not the human or mouse NTCP/Ntcp promoters, whereas C/EBPβ activation is specific to human and mouse. HNF3β is the only transcription factor binding and active at a conserved motif in all three species, where it inhibits NTCP/Ntcp promoter activity. Small heterodimer partner (SHP) does not affect NTCP/Ntcp promoter activity from the conserved region. Transfection-based luciferase reporter assays, electrophoretic mobility shift assay (EMSA), cotransfection in Huh7 cells American journal of physiology. Gastrointestinal and liver physiology High 14701722
2002 Short heterodimer partner 1 (SHP-1) induction by retained bile acids temporally precedes and likely mediates downregulation of Ntcp in obstructive cholestasis. In bile duct-ligated mice, SHP-1 mRNA peaked at 6 h after ligation, followed 6 h later by the nadir of Ntcp mRNA and protein. Northern and Western blotting of SHP-1 and Ntcp in CBDL mice, immunofluorescence American journal of physiology. Gastrointestinal and liver physiology Medium 11751172
2005 In obstructive cholestasis (CBDL), Ntcp downregulation is bile acid–mediated and FXR-dependent, not cytokine-mediated. FXR knockout mice fail to repress Ntcp after bile acid feeding or CBDL; LPS-induced Ntcp repression is FXR-independent. The mechanism involves reduced nuclear levels and DNA binding of HNF-1α, HNF-4α, RXRα, and RARα. FXR knockout mice, bile duct ligation, cholic acid feeding, LPS treatment, EMSA, Western blotting, cytokine inactivation American journal of physiology. Gastrointestinal and liver physiology High 16002565
2005 Kupffer cell depletion with liposomal clodronate prevents endotoxin-induced suppression of Ntcp expression. In endotoxin-exposed rats, KC depletion preserved Ntcp RNA and protein expression and maintained RXR:RAR and HNF1α transcription factor binding activity. Liposomal clodronate KC depletion, LPS exposure, Northern/Western blotting, EMSA in rats Journal of hepatology Medium 15629514
2005 In obstructive cholestasis in rodents, accumulating bile acids—independent of cytokines—downregulate Ntcp through repression of HNF-1α and HNF-4α. Both TNF-α/IL-1β neutralization and Kupffer cell depletion failed to restore Ntcp expression, while SHP mRNA increased 3–5-fold. Cytokine neutralization (etanercept, anakinra), KC depletion by liposome clodronate, Western/Northern blotting, EMSA in CBDL rats and mice Hepatology (Baltimore, Md.) Medium 15723437
2003 NTCP (Ntcp) facilitates hepatocellular uptake of the lethal mushroom toxin α-amanitin. HepG2 cells stably transfected with rat Ntcp showed markedly increased sensitivity to α-amanitin cytotoxicity compared to non-transfected cells, as measured by suppression of cytokine-induced IL-1Ra mRNA synthesis. Stable transfection of rat Ntcp in HepG2 cells, taurocholate uptake kinetics, functional toxicity assay (IL-1Ra mRNA induction) Archives of toxicology Medium 14598021
2006 Human NTCP and BSEP reconstituted together in LLC-PK1 polarized cells mediate vectorial transcellular transport of bile acids from the basolateral to apical side, with substrate specificities showing taurine conjugates > glycine conjugates > unconjugated bile salts for NTCP. Single-transporter cells showed no vectorial transport. Double transfection of LLC-PK1 cells with NTCP and BSEP, transcellular bile acid flux assays, kinetic analysis American journal of physiology. Gastrointestinal and liver physiology High 16474011
2017 N-linked glycosylation of NTCP at residues N5 and N11 is required for efficient trafficking to the plasma membrane and for HBV infection. NTCP lacking both glycosylation sites (N5,11Q) failed to support HBV infection, showed minimal cellular expression, and was degraded in lysosomes, while single-glycan variants retained normal bile acid transport function and HBV infectability. Site-directed mutagenesis of glycosylation sites, cell surface biotinylation, lysosomal degradation assay, HBV infection assay, bile acid uptake assay in HepG2 cells PloS one High 28125599
2003 The C800T (Ser267Phe) polymorphism in NTCP causes near-complete loss of bile acid uptake function while preserving transport of the non-bile acid substrate estrone sulfate, identifying position 267 as part of a region critical and specific for bile acid substrate recognition. Cell surface biotinylation showed normal plasma membrane expression of this variant. Cell surface biotinylation, taurocholate and estrone sulfate transport assays, immunofluorescence confocal microscopy in HepG2 and transfected cells The Journal of biological chemistry High 14660639
2013 A dileucine motif in the third intracellular loop of Ntcp is essential for both endocytosis and plasma membrane targeting, indicating a dual trafficking function. PKC-mediated endocytosis of Ntcp from the plasma membrane is clathrin-dependent and is followed by lysosomal degradation. Mutation of Thr225 and Ser226 inhibited PKC-mediated endocytosis. Flow cytometry, immunofluorescence, Western blotting, site-directed mutagenesis of dileucine motif and phosphorylation sites in HepG2 cells American journal of physiology. Gastrointestinal and liver physiology High 24008362
2010 Nitric oxide (NO) inhibits taurocholate uptake by NTCP via S-nitrosylation of cysteine residues on NTCP, causing non-competitive inhibition (decreased Vmax, unchanged Km) and reduction of NTCP at the plasma membrane. Dithiothreitol reversed both S-nitrosylation and transport inhibition. Biotin switch assay for S-nitrosylation, taurocholate kinetic uptake assay, plasma membrane biotinylation, NO donor treatment in HuH-NTCP cells American journal of physiology. Gastrointestinal and liver physiology High 21109590
2012 Plasma membrane localization of PKCδ, rather than its kinase activity, is necessary for cAMP-induced NTCP translocation and Rab4 activation. Kinase-dead dominant-negative PKCδ and PKCδ knockdown both still increased plasma membrane NTCP and Rab4 activity when PKCδ was at the membrane. In contrast, kinase activity of PKCδ is required for cAMP-induced MRP2 translocation. Wild-type, kinase-dead DN-PKCδ transfection, siRNA knockdown, Rab4 activity assay, rottlerin and LY294002 inhibitors in HuH-NTCP cells American journal of physiology. Gastrointestinal and liver physiology Medium 22744337
2015 IL-6 inhibits HBV entry into hepatocytes by downregulating NTCP: IL-6 pretreatment reduced NTCP mRNA by 98%, reduced NTCP-mediated taurocholate uptake by 80%, and inhibited HBV entry by up to 90%. Restoration of NTCP expression suppressed the inhibitory effect of IL-6, confirming that NTCP downregulation mediates the effect. HBV infection assay (cccDNA and HBsAg readouts), taurocholate uptake assay, NTCP mRNA quantification, NTCP restoration experiment Virology High 25765005
2014 Retinoic acid receptor (RAR) regulates human NTCP promoter activity via a binding site at nucleotides −112 to −96 of the NTCP gene. Pharmacological antagonism of RAR (Ro41-5253, CD2665) reduced NTCP mRNA and protein expression, blocked viral entry, and inhibited HBV spread across multiple genotypes. NTCP promoter luciferase assays, RAR ChIP, pharmacological RAR antagonists, HBV infection assay, NTCP mRNA/protein quantification in HepG2-hNTCP cells The Journal of biological chemistry Medium 25550158
2016 NTCP augments HCV infection by mediating bile-acid-dependent repression of interferon-stimulated genes (ISGs), including IFITM3. Gain- and loss-of-function studies in hepatocytes showed NTCP regulates innate antiviral immunity, with NTCP-mediated bile acid transport suppressing ISG expression and thereby increasing permissiveness to HCV infection. NTCP overexpression and knockdown in hepatoma cells, ISG expression profiling, HCV infection assay, bile acid treatment Cell reports Medium 27783949
2021 NTCP oligomerization occurs downstream of the NTCP-EGFR interaction and is required for HBV internalization. Troglitazone directly binds NTCP allosterically (non-competitive inhibition of bile acid uptake) and blocks NTCP oligomerization, inhibiting HBV internalization without affecting HBV attachment or the NTCP-EGFR interaction. The F274A mutation in NTCP disrupts oligomerization and HBV internalization without affecting viral surface binding. Surface plasmon resonance, transporter kinetics, alanine scanning mutagenesis, coimmunoprecipitation, NTCP oligomerization assay in transfected cells Journal of virology High 34613794
2022 IFITM3 is a protein-protein interaction partner of NTCP identified by membrane yeast-two-hybrid and confirmed by co-immunoprecipitation. IFITM3 knockdown significantly reduced HBV and HDV infection of NTCP-expressing HuH7 cells and primary human hepatocytes, despite intact myr-preS1 peptide binding to NTCP, indicating IFITM3 facilitates a post-attachment step of HBV/HDV entry. Membrane yeast-two-hybrid, co-immunoprecipitation, IFITM3 siRNA knockdown, HBV/HDV infection assays, myr-preS1 binding assay Viruses Medium 35458456
2019 OATP1B3 forms hetero-oligomers with NTCP in both HEK293 cells and frozen human liver sections. Coexpression of NTCP with OATP1B3 in HEK293 cells increased OATP1B3 plasma membrane expression but decreased its apparent turnover rate for the substrate cholecystokinin-8. Co-immunoprecipitation, proximity ligation assay, plasma membrane expression quantification, transport assay in HEK293T cells and human liver sections Drug metabolism and disposition Medium 32482756
2014 SLC10A1 deficiency (NTCP deficiency) was identified as an inborn error of metabolism in a patient with a homozygous R252H mutation. Functional studies showed markedly reduced taurocholate uptake activity, and immunofluorescence/surface biotinylation showed the mutant protein is virtually absent from the plasma membrane, confirming NTCP is the main hepatic import system for conjugated bile salts. SLC10A1 sequencing, taurocholic acid uptake assay, immunofluorescence, surface biotinylation Hepatology (Baltimore, Md.) High 24867799
2019 Cyclin D1 transcriptionally suppresses NTCP expression by inhibiting NTCP promoter activity during cell cycle progression. Ectopic expression of NTCP in HepG2 and Huh-7 cells suppressed hepatocyte growth by arresting cells in G0/G1 phase, identifying a functional link between NTCP expression and cell cycle regulation. NTCP promoter luciferase assay, cyclin D1 overexpression, cell cycle analysis (flow cytometry), ectopic NTCP expression in HCC cell lines Oncotarget Medium 28915572
2020 HBV uptake into HepG2-NTCP cells is dependent on the actin cytoskeleton and occurs via clathrin-mediated endocytosis. HBV internalisation was inhibited by pitstop-2 and siRNA silencing of clathrin heavy chain, adaptor protein AP-2, and dynamin-2. Entry via caveolae or macropinocytosis was excluded. HBV entry in clathrin-coated pits was visualised by electron microscopy and cryo-EM with immunogold labelling. siRNA knockdown of clathrin, AP-2, dynamin-2; pharmacological inhibitors; electron microscopy; cryo-EM immunogold labelling in HepG2-NTCP cells Cellular microbiology High 32216005
2019 NTCP genetic deletion in mice reduces diet-induced obesity, attenuates hepatic steatosis, and lowers plasma cholesterol by prolonging postprandial plasma bile acid elevations. The effect on obesity protection is TGR5-independent (NTCP/TGR5 double knockout mice showed equal protection). Mechanistically, NTCP knockout was associated with decreased intestinal fat absorption and increased uncoupled respiration in brown adipose tissue. NTCP knockout mice, NTCP/TGR5 double knockout mice, metabolic phenotyping, intestinal fat absorption assay, brown adipose tissue respiration measurement JCI insight High 31237863
2019 Myrcludex B (bulevirtide) binds NTCP with very high affinity, and the NTCP:Myrcludex B interaction is extremely long-lived. Pre-bound Myrcludex B can transfer from one NTCP molecule to newly synthesized NTCP, partly escaping co-degradation. The normalization of plasma bile salt levels correlates with NTCP protein turnover rate. FITC-labeled Myrcludex B tracking, biotin-labeled NTCP turnover assay, FRET by fluorescence lifetime imaging microscopy in U2OS cells JHEP reports Medium 32039379
2011 The A64T polymorphism of NTCP (SLC10A1) significantly decreased transport of both taurocholate and rosuvastatin compared to wild-type. The S267F polymorphism showed decreased taurocholate uptake but increased rosuvastatin uptake (substrate-dependent functional change), demonstrating position 267 as a substrate selectivity determinant. Stable transfection of NTCP variants, taurocholate and rosuvastatin uptake assays in transfected cells Xenobiotica Medium 21341987
1999 Two alternatively spliced isoforms of mouse Ntcp (Ntcp1 encoding 362 aa and Ntcp2 encoding 317 aa with a shorter C-terminus from intron retention) both mediate saturable Na+-dependent transport of taurocholate when expressed in Xenopus oocytes. cDNA library screening, Xenopus oocyte expression, taurocholate uptake assay Biochimica et biophysica acta High 10209268
2020 Position S267 in NTCP functions as an evolutionary 'rheostat': all 20 amino acid substitutions at this position produce progressive, varied effects on transport kinetics (Km and Vmax) and substrate specificity for taurocholic acid, estrone-3-sulfate, and rosuvastatin, rather than simple on/off effects. Stability modeling showed substitution tolerance correlates with surface expression but not transport activity. Systematic mutagenesis of all 20 amino acids at position 267, transport assays with three substrates, surface expression analysis, Rosetta stability modeling The Journal of biological chemistry High 33168628

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP. Biochemical and biophysical research communications 281 24342612
2011 The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation. Handbook of experimental pharmacology 210 21103971
2013 Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor. Journal of hepatology 205 24295872
2014 Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype. Hepatology (Baltimore, Md.) 176 24867799
2003 Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition. The Journal of biological chemistry 140 14660639
2014 Kinetics of the bile acid transporter and hepatitis B virus receptor Na+/taurocholate cotransporting polypeptide (NTCP) in hepatocytes. Journal of hepatology 126 24845614
2006 Inhibition of bile acid transport across Na+/taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs. Drug metabolism and disposition: the biological fate of chemicals 108 16760228
2014 NTCP and beyond: opening the door to unveil hepatitis B virus entry. International journal of molecular sciences 102 24557582
2002 Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent. The Journal of biological chemistry 101 12105223
2022 Structure of the bile acid transporter and HBV receptor NTCP. Nature 94 35580629
2015 The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B. Gut 88 26642861
2014 HBV life cycle is restricted in mouse hepatocytes expressing human NTCP. Cellular & molecular immunology 88 24509445
2015 Interleukin 6 inhibits HBV entry through NTCP down regulation. Virology 85 25765005
2011 Genetic polymorphisms in Na+-taurocholate co-transporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations. Xenobiotica; the fate of foreign compounds in biological systems 84 21341987
2022 Structural insights into the HBV receptor and bile acid transporter NTCP. Nature 83 35580630
2004 A TCP-NTCP estimation module using DVHs and known radiobiological models and parameter sets. Journal of applied clinical medical physics 80 15753933
2003 Semi quantitative expression analysis of MDR3, FIC1, BSEP, OATP-A, OATP-C,OATP-D, OATP-E and NTCP gene transcripts in 1st and 3rd trimester human placenta. Placenta 80 12495658
2003 Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene. American journal of physiology. Gastrointestinal and liver physiology 80 14701722
2015 The p.Ser267Phe variant in SLC10A1 is associated with resistance to chronic hepatitis B. Hepatology (Baltimore, Md.) 78 25418280
2007 Regulation of hepatic bile acid transporters Ntcp and Bsep expression. Biochemical pharmacology 74 17897632
2020 Hepatitis B virus entry into HepG2-NTCP cells requires clathrin-mediated endocytosis. Cellular microbiology 71 32216005
2005 Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver. American journal of physiology. Gastrointestinal and liver physiology 68 16002565
2015 Spinoculation Enhances HBV Infection in NTCP-Reconstituted Hepatocytes. PloS one 65 26070202
2019 Efficient long-term amplification of hepatitis B virus isolates after infection of slow proliferating HepG2-NTCP cells. Journal of hepatology 63 31077792
2006 Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep. American journal of physiology. Gastrointestinal and liver physiology 63 16474011
2002 Induction of short heterodimer partner 1 precedes downregulation of Ntcp in bile duct-ligated mice. American journal of physiology. Gastrointestinal and liver physiology 62 11751172
2015 NTCP opens the door for hepatitis B virus infection. Antiviral research 59 26071008
2014 Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression. The Journal of biological chemistry 56 25550158
2007 Obstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2. American journal of physiology. Gastrointestinal and liver physiology 55 17916651
2005 Kupffer cell depletion with liposomal clodronate prevents suppression of Ntcp expression in endotoxin-treated rats. Journal of hepatology 53 15629514
2012 Biological mechanisms of normal tissue damage: importance for the design of NTCP models. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 52 22748390
2017 NTCP-Reconstituted In Vitro HBV Infection System. Methods in molecular biology (Clifton, N.J.) 51 27975303
2011 Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 49 21605667
2006 PKCzeta is required for microtubule-based motility of vesicles containing the ntcp transporter. Traffic (Copenhagen, Denmark) 48 16734659
2002 Protein kinase B/Akt mediates cAMP- and cell swelling-stimulated Na+/taurocholate cotransport and Ntcp translocation. The Journal of biological chemistry 47 12034724
2015 The inhibition of hepatic bile acids transporters Ntcp and Bsep is involved in the pathogenesis of isoniazid/rifampicin-induced hepatotoxicity. Toxicology mechanisms and methods 46 25886055
2019 Down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes prevents hepatitis B virus infection. Emerging microbes & infections 45 31179847
2017 Homozygous p.Ser267Phe in SLC10A1 is associated with a new type of hypercholanemia and implications for personalized medicine. Scientific reports 43 28835676
2019 NTCP model for postoperative complications and one-year mortality after trimodality treatment in oesophageal cancer. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 42 31630867
1999 Molecular cloning and functional characterization of two alternatively spliced Ntcp isoforms from mouse liver1. Biochimica et biophysica acta 42 10209268
2019 NTCP deficiency in mice protects against obesity and hepatosteatosis. JCI insight 41 31237863
2013 Absolute measurement of species differences in sodium taurocholate cotransporting polypeptide (NTCP/Ntcp) and its modulation in cultured hepatocytes. Journal of pharmaceutical sciences 39 23657999
2005 Cytokine-independent repression of rodent Ntcp in obstructive cholestasis. Hepatology (Baltimore, Md.) 37 15723437
2021 Clinical effects of NTCP-inhibitor myrcludex B. Journal of viral hepatitis 36 33599010
2016 Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes. Cell reports 36 27783949
2003 The hepatocellular bile acid transporter Ntcp facilitates uptake of the lethal mushroom toxin alpha-amanitin. Archives of toxicology 36 14598021
2021 Molecular regulation of the hepatic bile acid uptake transporter and HBV entry receptor NTCP. Biochimica et biophysica acta. Molecular and cell biology of lipids 35 33932583
2017 N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection. PloS one 35 28125599
2011 Interaction of fluvastatin with the liver-specific Na+ -dependent taurocholate cotransporting polypeptide (NTCP). European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 35 21945488
2005 Dephosphorylation of Ser-226 facilitates plasma membrane retention of Ntcp. The Journal of biological chemistry 35 16027164
2002 Role of PP2B in cAMP-induced dephosphorylation and translocation of NTCP. American journal of physiology. Gastrointestinal and liver physiology 34 12065290
2024 Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP. Nature communications 33 38509088
2015 NTCP reduction for advanced head and neck cancer patients using proton therapy for complete or sequential boost treatment versus photon therapy. Acta oncologica (Stockholm, Sweden) 33 26340301
2019 Tanshinone IIA prevents rifampicin-induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2. Liver international : official journal of the International Association for the Study of the Liver 32 31571363
2017 Sodium taurocholate cotransporting polypeptide (NTCP) deficiency: Identification of a novel SLC10A1 mutation in two unrelated infants presenting with neonatal indirect hyperbilirubinemia and remarkable hypercholanemia. Oncotarget 32 29290974
2007 NTCP modelling and pulmonary function tests evaluation for the prediction of radiation induced pneumonitis in non-small-cell lung cancer radiotherapy. Physics in medicine and biology 32 17264370
2019 Mechanistic insights into the inhibition of NTCP by myrcludex B. JHEP reports : innovation in hepatology 31 32039379
2022 Radiation-Induced Esophagitis in Non-Small-Cell Lung Cancer Patients: Voxel-Based Analysis and NTCP Modeling. Cancers 30 35406605
2005 Degradation of the sodium taurocholate cotransporting polypeptide (NTCP) by the ubiquitin-proteasome system. Biological chemistry 30 16218878
2021 Curcumin inhibited hepatitis B viral entry through NTCP binding. Scientific reports 29 34580340
2020 NTCP Models for Severe Radiation Induced Dermatitis After IMRT or Proton Therapy for Thoracic Cancer Patients. Frontiers in oncology 29 32257950
2002 Effect of Ursodeoxycholic Acid on the Expression of the Hepatocellular Bile Acid Transporters (Ntcp and bsep) in Rats With Estrogen-Induced Cholestasis. Journal of pediatric gastroenterology and nutrition 29 12187295
2019 NTCP S267F variant associates with decreased susceptibility to HBV and HDV infection and decelerated progression of related liver diseases. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 28 30685591
2014 LASSO NTCP predictors for the incidence of xerostomia in patients with head and neck squamous cell carcinoma and nasopharyngeal carcinoma. Scientific reports 27 25163814
2013 Taurolithocholate-induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase Cϵ in HUH-NTCP Cells. Hepatology (Baltimore, Md.) 27 23424156
2012 Protein kinase Cδ differentially regulates cAMP-dependent translocation of NTCP and MRP2 to the plasma membrane. American journal of physiology. Gastrointestinal and liver physiology 27 22744337
2010 Sustained repression and translocation of Ntcp and expression of Mrp4 for cholestasis after rat 90% partial hepatectomy. Journal of hepatology 27 21167233
2020 A clinically relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position. The Journal of biological chemistry 26 33168628
2013 A dileucine motif is involved in plasma membrane expression and endocytosis of rat sodium taurocholate cotransporting polypeptide (Ntcp). American journal of physiology. Gastrointestinal and liver physiology 26 24008362
2021 Substrate Specificities and Inhibition Pattern of the Solute Carrier Family 10 Members NTCP, ASBT and SOAT. Frontiers in molecular biosciences 25 34079822
2018 The Loss-of-Function S267F Variant in HBV Receptor NTCP Reduces Human Risk for HBV Infection and Disease Progression. The Journal of infectious diseases 25 29905807
2016 Genetic variants in the regulatory region of SLC10A1 are not associated with the risk of hepatitis B virus infection and clearance. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 25 27491457
2014 Identification of NTCP as an HBV receptor: the beginning of the end or the end of the beginning? Gastroenterology 24 24576732
2022 IFITM3 Interacts with the HBV/HDV Receptor NTCP and Modulates Virus Entry and Infection. Viruses 23 35458456
2015 Design and synthesis of a novel candidate compound NTI-007 targeting sodium taurocholate cotransporting polypeptide [NTCP]-APOA1-HBx-Beclin1-mediated autophagic pathway in HBV therapy. Bioorganic & medicinal chemistry 23 25650312
1999 Decreased Na+-dependent taurocholate uptake and low expression of the sinusoidal Na+-taurocholate cotransporting protein (Ntcp) in livers of mdr2 P-glycoprotein-deficient mice. Journal of hepatology 23 9927146
2019 Concept of Viral Inhibitors via NTCP. Seminars in liver disease 22 30809790
2018 The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses. Cellular and molecular life sciences : CMLS 22 30097692
2016 Down-regulation of NTCP expression by cyclin D1 in hepatitis B virus-related hepatocellular carcinoma has clinical significance. Oncotarget 22 28915572
2014 Transport of the soy isoflavone daidzein and its conjugative metabolites by the carriers SOAT, NTCP, OAT4, and OATP2B1. Archives of toxicology 21 25319728
2021 NTCP Oligomerization Occurs Downstream of the NTCP-EGFR Interaction during Hepatitis B Virus Internalization. Journal of virology 20 34613794
2020 In Vitro Functional Characterization and in Silico Prediction of Rare Genetic Variation in the Bile Acid and Drug Transporter, Na+-Taurocholate Cotransporting Polypeptide (NTCP, SLC10A1). Molecular pharmaceutics 20 32101444
2019 Evolution of Hepatitis B Virus Receptor NTCP Reveals Differential Pathogenicities and Species Specificities of Hepadnaviruses in Primates, Rodents, and Bats. Journal of virology 20 30541833
2017 Genetic variations of NTCP are associated with susceptibility to HBV infection and related hepatocellular carcinoma. Oncotarget 20 29285260
2016 A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population. BMC cancer 20 26968990
2016 Monoammonium glycyrrhizinate protects rifampicin- and isoniazid-induced hepatotoxicity via regulating the expression of transporter Mrp2, Ntcp, and Oatp1a4 in liver. Pharmaceutical biology 20 26987268
2022 Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection. Journal of virology 19 34985994
2020 Long-term trans-inhibition of the hepatitis B and D virus receptor NTCP by taurolithocholic acid. American journal of physiology. Gastrointestinal and liver physiology 19 33174454
2019 The Role of the Sodium-taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) in Related Liver Disease. Current drug metabolism 19 31258056
2018 SPECT/CT-guided elective nodal irradiation for head and neck cancer: Estimation of clinical benefits using NTCP models. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 19 30087057
2017 The role of Ntcp, Oatp2, Bsep and Mrp2 in liver injury induced by Dioscorea bulbifera L. and Diosbulbin B in mice. Environmental toxicology and pharmacology 19 28262508
2017 Kinetic characterization of bile salt transport by human NTCP (SLC10A1). Toxicology in vitro : an international journal published in association with BIBRA 18 29024779
2020 Potent and Specific Inhibition of NTCP-Mediated HBV/HDV Infection and Substrate Transporting by a Novel, Oral-Available Cyclosporine A Analogue. Journal of medicinal chemistry 17 33369415
2010 Nitric oxide-mediated inhibition of taurocholate uptake involves S-nitrosylation of NTCP. American journal of physiology. Gastrointestinal and liver physiology 17 21109590
2009 PKC{epsilon}-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line. American journal of physiology. Gastrointestinal and liver physiology 17 19815625
2022 Multitasking Na+/Taurocholate Cotransporting Polypeptide (NTCP) as a Drug Target for HBV Infection: From Protein Engineering to Drug Discovery. Biomedicines 16 35052874
2022 Regulation of the HBV Entry Receptor NTCP and its Potential in Hepatitis B Treatment. Frontiers in molecular biosciences 16 35495620
2018 Genetic variants in NTCP exon gene are associated with HBV infection status in a Chinese Han population. Hepatology research : the official journal of the Japan Society of Hepatology 16 29205714
2021 Clinical characterization of NTCP deficiency in paediatric patients : A case-control study based on SLC10A1 genotyping analysis. Liver international : official journal of the International Association for the Study of the Liver 15 34369070
2020 OATP1B3 Expression and Function is Modulated by Coexpression with OCT1, OATP1B1, and NTCP. Drug metabolism and disposition: the biological fate of chemicals 15 32482756

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