Affinage

SGMS1

Phosphatidylcholine:ceramide cholinephosphotransferase 1 · UniProt Q86VZ5

Length
413 aa
Mass
48.6 kDa
Annotated
2026-06-10
100 papers in source corpus 6 papers cited in narrative 6 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SGMS1 (sphingomyelin synthase 1) is a Golgi-localized enzyme that governs cellular sphingomyelin homeostasis, partitioning the ceramide/sphingomyelin balance that underlies membrane organization and downstream signaling (PMID:17449912). Depletion of SMS1 lowers sphingomyelin and causes ceramide accumulation, blocking cell growth in a manner not rescued by exogenous sphingomyelin, indicating its role extends beyond bulk lipid supply (PMID:17449912). By supplying sphingomyelin to membrane microdomains, SMS1 is required for lipid raft integrity: its loss in T cells prevents translocation of TCR, ZAP-70, and PKC into rafts and impairs CD3-induced signaling and T cell activation (PMID:18820264). The same ceramide/sphingomyelin switch links SMS1 to differentiation programs—in mesenchymal stem cells SGMS1 lowers ceramide and restrains PP2A, enhancing phosphorylated Akt, Runx2, and VEGF to drive osteogenesis and angiogenesis, with Runx2 feeding back onto SGMS1 transcription (PMID:38544565), while a ROR2/STK4–FOXO1 axis represses SGMS1 transcription through direct FOXO1 binding to its promoter (PMID:34278704). At the organ level, SGMS1 is required to maintain the endocochlear potential, where its knockout in mice produces progressive hearing loss with stria vascularis marginal cell dysfunction and patchy Kcnq1 loss, and a threshold of residual expression suffices for normal hearing (PMID:39067415).

Mechanistic history

Synthesis pass · year-by-year structured walk · 6 steps
  1. 2005 Medium

    Established the gene architecture of SMS1 and that its isoforms carry distinct functional outputs, opening the question of isoform-specific roles in cell survival.

    Evidence RT-PCR, genomic structure analysis, and yeast Bax-complementation assays of mouse SMS1 splice variants

    PMID:16226406

    Open questions at the time
    • Functional readout limited to a yeast Bax-growth assay rather than mammalian cells
    • Mechanism by which SMS1alpha prevents Bax-induced growth inhibition not defined
    • Link between TNF-alpha induction and enzymatic activity not established
  2. 2007 High

    Defined SMS1 as the Golgi-resident sphingomyelin synthase whose activity is rate-limiting for SM production and cell growth, resolving where in the cell SM is made.

    Evidence RNAi knockdown with lipid mass measurements, subcellular localization, and growth assays in HeLa cells

    PMID:17449912

    Open questions at the time
    • Mechanism linking ceramide accumulation to growth arrest not resolved
    • Catalytic mechanism and substrate kinetics not characterized in this study
  3. 2008 High

    Showed that SMS1-derived sphingomyelin is required for lipid raft integrity and TCR signal transduction, connecting the enzyme to immune cell activation.

    Evidence siRNA knockdown in Jurkat T cells with lipid raft fractionation, immunoprecipitation, and T cell activation assays

    PMID:18820264

    Open questions at the time
    • Single cell line and single lab
    • Whether the defect reflects raft composition versus a specific SM-protein interaction not distinguished
  4. 2021 Medium

    Identified transcriptional control of SGMS1 by a ROR2/STK4–FOXO1 axis, explaining how SM synthesis is downregulated during stem cell senescence.

    Evidence siRNA/overexpression, ChIP for FOXO1 binding to the SMS1 promoter, and phosphorylation Westerns in dental pulp stem cells

    PMID:34278704

    Open questions at the time
    • Single lab and single cell type
    • Direct FOXO1 binding site sequence not mapped beyond ChIP
    • Generality across other SGMS1-expressing tissues unknown
  5. 2024 Medium

    Placed SGMS1 within an osteogenic signaling circuit, showing it acts through the ceramide/PP2A/Akt–Runx2 pathway and forms a transcriptional feedback loop with Runx2.

    Evidence Knockdown/overexpression with lipid measurements, signaling Westerns, SM-supplementation rescue, and an in vivo rat bone regeneration model

    PMID:38544565

    Open questions at the time
    • Direct enzymatic versus signaling contributions to PP2A restraint not separated
    • Single lab
    • Whether Runx2 binds the SGMS1 promoter directly not shown
  6. 2024 High

    Demonstrated an essential, dose-dependent in vivo role for SGMS1 in maintaining the endocochlear potential, localizing its physiological requirement to stria vascularis marginal cells.

    Evidence Constitutive Sgms1 knockout mice with auditory brainstem response, endocochlear potential measurement, and Kcnq1 immunofluorescence

    PMID:39067415

    Open questions at the time
    • Molecular link between SM synthesis and Kcnq1 maintenance not defined
    • Whether the defect is cell-autonomous to marginal cells not established
    • Human hearing-loss association not tested in this study

Open questions

Synthesis pass · forward-looking unresolved questions
  • How SGMS1's local ceramide/sphingomyelin switch is mechanistically transduced into distinct downstream outputs—raft-dependent signaling, PP2A/Akt control, and ion-channel maintenance—across different cell types remains unresolved.
  • No structural model of the enzyme in the corpus
  • Substrate channeling and compartment-specific lipid pools not dissected
  • Causal chain from SM levels to specific effector proteins (KCNQ1, PP2A) not mechanistically defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 2
Localization
GO:0005794 Golgi apparatus 1
Pathway
R-HSA-1430728 Metabolism 2

Evidence

Reading pass · 6 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 SMS1 localizes to the Golgi and SMS2 localizes to the plasma membrane in HeLa cells; both function as the key SM synthases at these respective compartments. RNAi-mediated depletion of either SMS1 or SMS2 caused substantial decreases in sphingomyelin production, accumulation of ceramide, and a block in cell growth. External addition of SM did not restore growth, indicating the biological role of SMS synthases extends beyond SM formation. RNA interference (RNAi) knockdown, lipid analysis, subcellular fractionation/localization, cell growth assays in HeLa cells The Journal of biological chemistry High 17449912
2008 SMS1 knockdown in Jurkat T cells (SMS1-siRNA) severely reduced membrane sphingomyelin expression and impaired TCR signal transduction: CD3 stimulation failed to induce CD69 expression, cell adhesion, proliferation, and TCR clustering. CD3-induced tyrosine phosphorylation, LAT association with ZAP-70 and Grb2, and PKC phosphorylation were impaired. Translocation of TCR, ZAP-70, and PKC into lipid rafts was markedly decreased, indicating SMS1-produced sphingomyelin is essential for lipid raft integrity and TCR signaling. siRNA knockdown of SMS1 in Jurkat T cells, flow cytometry, immunoprecipitation, lipid raft fractionation, proliferation assays International immunology High 18820264
2005 The mouse SMS1 gene is alternatively spliced to produce four mRNA transcripts (SMS1alpha1, SMS1alpha2, SMS1beta, SMS1gamma) encoding three different proteins (SMS1alpha, SMS1beta, SMS1gamma). SMS1alpha prevents Bax-induced growth inhibition in a yeast-based assay, while SMS1beta neither prevents nor enhances the effects of Bax or SMS1alpha, indicating isoform-specific functional differences. SMS1 transcripts increase in response to pro-apoptotic TNF-alpha. RT-PCR, genomic structure analysis, yeast functional complementation assay (Bax growth inhibition), Northern blot Gene Medium 16226406
2021 ROR2 depletion in dental pulp stem cells (DPSCs) inhibits SMS1 expression and sphingomyelin biosynthesis. Mechanistically, ROR2 inhibits STK4 phosphorylation, which promotes FOXO1 nuclear translocation; nuclear FOXO1 directly binds the SMS1 promoter and represses its transcription. STK4 inhibition or FOXO1 knockdown upregulated SMS1 expression and increased SM levels, reversing the senescence phenotype. This defines a ROR2/STK4-FOXO1/SMS1 regulatory axis controlling sphingomyelin synthesis and DPSC senescence. siRNA knockdown, overexpression, ChIP (FOXO1 binding to SMS1 promoter), Western blot for phosphorylation, proliferation assays, lipid analysis Aging cell Medium 34278704
2024 SGMS1 promotes osteogenic differentiation of mesenchymal stem cells (MSCs) by regulating ceramide/sphingomyelin metabolism: SGMS1 overexpression inhibits ceramide and increases sphingomyelin levels, thereby restraining PP2A activity and enhancing phosphorylated Akt, Runx2, and VEGF levels. SM treatment neutralized the suppressive effect of SGMS1 silencing on osteogenesis. SGMS1 transcription is regulated by Runx2 (feedback loop). SGMS1 promotes MSC-mediated angiogenesis via VEGF upregulation and accelerates bone regeneration in vivo. siRNA knockdown and overexpression of SGMS1, lipid measurements (ceramide/SM), Western blot (PP2A activity, pAkt, Runx2, VEGF), SM supplementation rescue experiments, in vivo rat bone regeneration model iScience Medium 38544565
2024 Complete knockout of Sgms1 (exon 7 deletion, Sgms1tm1b) in mice causes progressive hearing loss with a consistently reduced endocochlear potential (~80 mV vs ~120 mV in controls). The stria vascularis showed irregular marginal cell surfaces and patchy loss of Kcnq1 expression, with marginal cells identified as the likely initial site of dysfunction. A partial knockdown allele (20% residual transcript) was sufficient for normal hearing, indicating a threshold requirement for SMS1 in maintaining endocochlear potential. Conditional/constitutive mouse knockout (Sgms1tm1b), auditory brainstem response, endocochlear potential measurement, immunofluorescence (Kcnq1), gene expression analysis of lateral wall Hearing research High 39067415

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell 474 15766530
1984 High frequency mobilization of gram-negative bacterial replicons by the in vitro constructed Tn5-Mob transposon. Molecular & general genetics : MGG 334 6094969
2001 Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. The Journal of biological chemistry 225 11706020
2007 Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells. The Journal of biological chemistry 189 17449912
2007 Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila. The EMBO journal 175 17347649
1996 Involvement of the narJ and mob gene products in distinct steps in the biosynthesis of the molybdoenzyme nitrate reductase in Escherichia coli. Molecular microbiology 141 8793883
1987 Transposon Mutagenesis of Azospirillum brasilense and Azospirillum lipoferum: Physical Analysis of Tn5 and Tn5-Mob Insertion Mutants. Applied and environmental microbiology 111 16347289
2020 MOBscan: Automated Annotation of MOB Relaxases. Methods in molecular biology (Clifton, N.J.) 99 31584171
2005 Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation. Molecular and cellular biology 97 16135814
2011 MOB control: reviewing a conserved family of kinase regulators. Cellular signalling 91 21539912
2004 Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. The Journal of biological chemistry 85 15067004
2012 A degenerate primer MOB typing (DPMT) method to classify gamma-proteobacterial plasmids in clinical and environmental settings. PloS one 81 22792321
1994 SMS1, a high-copy suppressor of the yeast mas6 mutant, encodes an essential inner membrane protein required for mitochondrial protein import. Molecular biology of the cell 78 7919535
2000 CCK stimulates mob-1 expression and NF-kappaB activation via protein kinase C and intracellular Ca(2+). American journal of physiology. Cell physiology 77 10666030
2014 Silencing the mob: disrupting quorum sensing as a means to fight plant disease. Molecular plant pathology 71 25113857
2005 Drosophila Mob family proteins interact with the related tricornered (Trc) and warts (Wts) kinases. Molecular biology of the cell 70 15975907
1994 Ras activation of genes: Mob-1 as a model. Proceedings of the National Academy of Sciences of the United States of America 65 7809069
2003 Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways. Structure (London, England : 1993) 61 12962634
2010 Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases. Molecular and cellular biology 53 20624913
1999 Cholecystokinin induction of mob-1 chemokine expression in pancreatic acinar cells requires NF-kappaB activation. The American journal of physiology 53 10409110
2008 Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells. International immunology 52 18820264
2009 Two NDR kinase-MOB complexes function as distinct modules during septum formation and tip extension in Neurospora crassa. Molecular microbiology 50 19788544
2000 Interaction between the RP4 coupling protein TraG and the pBHR1 mobilization protein Mob. Molecular microbiology 50 10998162
1994 Isolation of protein FA, a product of the mob locus required for molybdenum cofactor biosynthesis in Escherichia coli. European journal of biochemistry 50 8020507
2002 Mammalian achaete scute homolog 2 is expressed in the adult sciatic nerve and regulates the expression of Krox24, Mob-1, CXCR4, and p57kip2 in Schwann cells. The Journal of neuroscience : the official journal of the Society for Neuroscience 44 12196582
1984 A portable DNA sequence carrying the cohesive site (cos) of bacteriophage lambda and the mob (mobilization) region of the broad-host-range plasmid RK2: a module for the construction of new cosmids. Gene 44 6099312
2009 Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila. Developmental biology 43 19913529
1995 Association of molybdopterin guanine dinucleotide with Escherichia coli dimethyl sulfoxide reductase: effect of tungstate and a mob mutation. Journal of bacteriology 41 7721698
2015 The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism. PLoS biology 38 25966461
2019 MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer. Cells 36 31185650
2019 The Opposing Contribution of SMS1 and SMS2 to Glioma Progression and Their Value in the Therapeutic Response to 2OHOA. Cancers 31 30646599
2008 The mob as tumor suppressor gene is essential for early development and regulates tissue growth in Drosophila. Genetics 30 18245354
1998 Tn4451 from Clostridium perfringens is a mobilizable transposon that encodes the functional Mob protein, TnpZ. Molecular microbiology 29 9489674
1997 Mob-1, a Ras target gene, is overexpressed in colorectal cancer. Oncogene 29 9129152
2004 Identification of functional mob regions in Rhizobium etli: evidence for self-transmissibility of the symbiotic plasmid pRetCFN42d. Journal of bacteriology 28 15317780
2007 Expression of CXC chemokine IP-10/Mob-1 by primary hepatocytes following heat shock. Saudi medical journal 25 17457469
2021 LncRNA SGMS1-AS1 regulates lung adenocarcinoma cell proliferation, migration, invasion, and EMT progression via miR-106a-5p/MYLI9 axis. Thoracic cancer 23 34061466
2020 Mob Family Proteins: Regulatory Partners in Hippo and Hippo-Like Intracellular Signaling Pathways. Frontiers in cell and developmental biology 23 32266255
2005 The mouse sphingomyelin synthase 1 (SMS1) gene is alternatively spliced to yield multiple transcripts and proteins. Gene 23 16226406
2019 Characterization of a relaxase belonging to the MOBT family, a widespread family in Firmicutes mediating the transfer of ICEs. Mobile DNA 22 31073337
2000 Identification of the mob genes of plasmid pSC101 and characterization of a hybrid pSC101-R1162 system for conjugal mobilization. Journal of bacteriology 22 10940031
2024 2D MoB MBene: An Efficient Co-Catalyst for Photocatalytic Hydrogen Production under Visible Light. ACS nano 21 38687979
2003 A cryptic plasmid of Yersinia enterocolitica encodes a conjugative transfer system related to the regions of CloDF13 Mob and IncX Pil. Microbiology (Reading, England) 21 14523116
1995 The mob locus of Escherichia coli K12 required for molybdenum cofactor biosynthesis is expressed at very low levels. Microbiology (Reading, England) 21 7551035
2005 Alfalfa Mob 1-like genes are expressed in reproductive organs during meiosis and gametogenesis. Plant molecular biology 20 16240174
2004 Modified RP4 and Tn5-Mob derivatives for facilitated manipulation of large plasmids in Gram-negative bacteria. Plasmid 20 15212888
2007 Characterization and evolution of the cell cycle-associated mob domain-containing proteins in eukaryotes. Evolutionary bioinformatics online 19 19468312
2000 Expression and regulation of the CXC-chemokines, GRO/KC and IP-10/mob-1 in rat seminiferous tubules. European cytokine network 19 11125315
2021 Direct MoB MBene domain formation in magnetron sputtered MoAlB thin films. Nanoscale 18 34726227
2019 Cis-Acting Relaxases Guarantee Independent Mobilization of MOBQ 4 Plasmids. Frontiers in microbiology 18 31781067
2021 Downregulation of ROR2 promotes dental pulp stem cell senescence by inhibiting STK4-FOXO1/SMS1 axis in sphingomyelin biosynthesis. Aging cell 17 34278704
2012 Genome-wide characterization of Vibrio phage φpp2 with unique arrangements of the mob-like genes. BMC genomics 17 22676552
1995 Mob-1 expression in IL-2-induced ARDS: regulation by TNF-alpha. The American journal of physiology 17 8572251
2012 A sensitive cell-based method to screen for selective inhibitors of SMS1 or SMS2 using HPLC and a fluorescent substrate. Chemistry and physics of lipids 15 23063490
2011 Human sphingomyelin synthase 1 gene (SMS1): organization, multiple mRNA splice variants and expression in adult tissues. Gene 15 21549185
2004 Human gene MOB: structure specification and aspects of transcriptional activity. Gene 15 15315829
1997 The novel chemokine mob-1: involvement in adult respiratory distress syndrome. Surgery 15 9288136
1995 The SMS1 gene encoding a serine-rich transmembrane protein suppresses the temperature sensitivity of the htr1 disruptant in Saccharomyces cerevisiae. Biochimica et biophysica acta 15 7999801
2008 Characterization of KlGRR1 and SMS1 genes, two new elements of the glucose signaling pathway of Kluyveromyces lactis. Eukaryotic cell 14 18552281
1990 Mobilization of Escherichia coli R1 silver-resistance plasmid pJT1 by Tn5-Mob into Escherichia coli C600. Biology of metals 14 2169281
2010 Genetic and functional analyses of the mob operon on conjugative transposon CTn341 from Bacteroides spp. Journal of bacteriology 13 20639338
2008 The r1162 mob proteins can promote conjugative transfer from cryptic origins in the bacterial chromosome. Journal of bacteriology 13 19074386
1991 Effects of prostaglandin E2 and F2 alpha on cytoplasmic pH in a clonal osteoblast-like cell line, MOB 3-4. Journal of cellular physiology 13 1846635
1990 Initial responses of a clonal osteoblast-like cell line, MOB 3-4, to phosphatidic acid in vitro. Bone and mineral 13 2168776
1998 Characterisation of the mob locus from Rhodobacter sphaeroides required for molybdenum cofactor biosynthesis. Biochimica et biophysica acta 12 9473631
1989 Aluminum enhances the stimulatory effect of NaF on prostaglandin E2 synthesis in a clonal osteoblast-like cell line, MOB 3-4, in vitro. Journal of biochemistry 11 2777755
2020 MOB: Pivotal Conserved Proteins in Cytokinesis, Cell Architecture and Tissue Homeostasis. Biology 9 33255245
2024 SGMS1 facilitates osteogenic differentiation of MSCs and strengthens osteogenesis-angiogenesis coupling by modulating Cer/PP2A/Akt pathway. iScience 8 38544565
2020 Ndr/Lats Kinases Bind Specific Mob-Family Coactivators through a Conserved and Modular Interface. Biochemistry 8 32250593
2002 In vitro and in silico analysis of the predicted human MOB gene encoding a phylogenetically conserved transmembrane protein. Biomolecular engineering 8 11841947
2013 Mob as tumor suppressor is regulated by bantam microRNA through a feedback loop for tissue growth control. Biochemical and biophysical research communications 7 24016667
2001 Characterisation of the mob locus of Rhodobacter sphaeroides WS8: mobA is the only gene required for molybdopterin guanine dinucleotide synthesis. Archives of microbiology 7 11479704
1991 Aluminofluoride- and epidermal growth factor-stimulated DNA synthesis in MOB 3-4-F2 cells. Pharmacology & toxicology 7 1803346
2016 Mob/oriT, a mobilizable site-specific recombination system for unmarked genetic manipulation in Bacillus thuringiensis and Bacillus cereus. Microbial cell factories 6 27286821
2004 Involvement of M3 cholinergic receptor signal transduction pathway in regulation of the expression of chemokine MOB-1, MCP-1 genes in pancreatic acinar cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 6 15315164
2002 MOB-1 and TNF-alpha interact to induce microvascular lung injury. Shock (Augusta, Ga.) 6 12353928
2001 DNA cloning in Lactobacillus helveticus by the exconjugation of recombinant mob-containing plasmid constructs from strains of transformable lactic acid bacteria. Plasmid 6 11735368
1988 Mobilization and transfer of Azospirillum lipoferum plasmid by the Tn5-Mob transposon into a plasmid-free Agrobacterium tumefaciens strain. Canadian journal of microbiology 6 2852995
2024 A new mutation of Sgms1 causes gradual hearing loss associated with a reduced endocochlear potential. Hearing research 5 39067415
2023 Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex. The Journal of biological chemistry 5 37536630
2020 Function of the MOB kinase activator-like 1 in the innate immune defense of the oriental river prawn (Macrobrachium nipponense). Fish & shellfish immunology 5 32418908
2014 [Expression of sphingomyelin synthase 1 (SGMS1) gene varies in human lung and oesophagus cancer]. Molekuliarnaia biologiia 5 25831888
2000 Deletions of mob and tra pJP4 transfer functions after mating of Ralstonia eutropha JMP134 (pJP4) with Escherichia coli harboring F'::Tn10. Canadian journal of microbiology 5 10872085
2022 Manganese oxidation counteracts the deleterious effect of low temperatures on biofilm formation in Pseudomonas sp. MOB-449. Frontiers in molecular biosciences 4 36339723
2021 The NDR kinase-MOB complex FgCot1-Mob2 regulates polarity and lipid metabolism in Fusarium graminearum. Environmental microbiology 4 34347361
2015 [Alternative promoters localised in SGMS1 gene introns take part in regulation of its expression in human tissues]. Molekuliarnaia biologiia 4 26065260
2015 The Xis2d protein of CTnDOT binds to the intergenic region between the mob and tra operons. Plasmid 4 26212728
2014 Morphogenesis: a Mob rules from the rear. Current biology : CB 4 25093564
2024 MOB-mediated regulation of septation initiation network (SIN) signaling is required for echinocandin-induced hyperseptation in Aspergillus fumigatus. mSphere 3 38349166
2022 PLASmid TAXonomic PCR (PlasTax-PCR), a Multiplex Relaxase MOB Typing to Assort Plasmids into Taxonomic Units. Methods in molecular biology (Clifton, N.J.) 3 34773620
2025 When to mob? plasticity of antipredator behavior in common ravens' families (Corvus corax) across offspring development. Animal cognition 2 40608153
2023 SGMS1-AS1/MicroRNA-106a-5p/CPT2 Axis as a Novel Target for Regulating Lactate Metabolism in Colon Cancer. Technology in cancer research & treatment 2 37926998
2016 PECULIARITIES OF THE STRUCTURE AND EXPRESSION OF HUMAN SPHINGOMYELIN SYNTHASE 1 GENE (SGMS1). Tsitologiia 2 30191692
2010 Characterization and mapping of a novel mutant sms1 (senescence and male sterility 1) in rice. Journal of genetics and genomics = Yi chuan xue bao 2 20171577
2009 The mob as tumor suppressor (mats1) gene is required for growth control in developing zebrafish embryos. The International journal of developmental biology 2 19247963
1992 Effect of phorbol myristate acetate on release of arachidonic acid and its metabolites in the osteoblastic MOB 3-4 cell line and its subclone, MOB 3-4-F2. Cellular signalling 2 1571204
1991 Starvation of a clonal osteoblast-like cell line, MOB 3-4-F2, down-regulates prostaglandin E2 receptors but increases cAMP response to prostaglandin E2. Cellular signalling 2 1652270
2023 MOB kinase activator 1A acts as an oncogene by targeting PI3K/AKT/mTOR in ovarian cancer. Discover oncology 1 37314589
2011 Molecular cloning, sequence characterization, and tissue expression analysis of chicken sphingomyelin synthase 1 (SMS1). Molecular and cellular biochemistry 1 21647613
1992 Chromosome mobilization of Legionella pneumophila with RK2::Mu and Tn5-Mob. Canadian journal of microbiology 1 1327483

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