Affinage

SEMA6A

Semaphorin-6A · UniProt Q9H2E6

Length
1030 aa
Mass
114.4 kDa
Annotated
2026-06-10
27 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/6 claims corpus-supported (83%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SEMA6A encodes a transmembrane class 6 semaphorin that acts as a contact-dependent guidance cue coordinating cell migration, axon guidance, and tissue cohesion across multiple developmental contexts (PMID:18327254, PMID:24917502). In forward (trans) signaling, SEMA6A engages the receptors PlexinA2 or PlexinA4 on neighboring cells: through PlexinA2 it drives cerebellar granule cell migration by coupling the centrosome and nucleus and coordinating motility (PMID:18327254), regulates interkinetic nuclear migration of retinal progenitors (PMID:27301906), maintains eye vesicle cohesion via repulsion (PMID:24917502), inhibits adult sensory and corticospinal axon growth (PMID:22564823), and promotes RANKL-induced osteoclastogenesis through PLCγ-mediated NFATc1 activation (PMID:30826495); through PlexinA4 it controls autonomous migration of oligodendrocyte precursors (PMID:23376059). SEMA6A also engages PlexinA4 in cis on the same cell surface, which blocks trans-ligand binding and tunes the repulsive guidance response in a neuron-type-specific manner (PMID:20606624). Independently of trans receptor binding, SEMA6A reverse signaling through its cytoplasmic domain maintains retinal integrity and Müller glia function and partitions hippocampal mossy fiber bundles (PMID:38963001), and the cytoplasmic tail binds the Ena/VASP-like protein EVL through a zyxin-like C-terminal domain, linking the receptor to actin cytoskeletal dynamics (PMID:10993894). SEMA6A is required for oligodendrocyte differentiation and myelination (PMID:22777942) and for GnRH neuron innervation and median eminence vascular permeability controlling puberty onset, with a pathogenic SEMA6A variant identified in patients with delayed puberty (PMID:38062045). Beyond neural development, SEMA6A is co-opted in cancer, where it drives actin remodeling and survival via a RhoA/YAP axis in BRAF-mutant melanoma (PMID:35440004) and promotes ccRCC proliferation as a direct HIF-2α target that activates Wnt/β-catenin signaling through interaction with SEC62 (PMID:36739418).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2000 Medium

    Established the first intracellular partner of SEMA6A, connecting its cytoplasmic tail to actin regulatory machinery and raising the possibility of retrograde/reverse signaling.

    Evidence Yeast two-hybrid, pulldown, and colocalization with C-terminal zyxin-like domain mapping in a heterologous system

    PMID:10993894

    Open questions at the time
    • No in vivo demonstration that EVL binding mediates a SEMA6A function
    • Functional consequence of the interaction for actin dynamics not measured
  2. 2005 High

    Defined SEMA6A's developmental role by showing it is required non-cell-autonomously for cerebellar granule cell radial migration, framing it as a guidance/migration cue rather than an intrinsic motility factor.

    Evidence Knockout mouse analysis, chimera studies, and cerebellar explant migration assays

    PMID:16205717

    Open questions at the time
    • Receptor not yet identified in this study
    • Molecular mechanism of nuclear/soma translocation control unresolved
  3. 2008 High

    Identified PlexinA2 as the functional trans receptor for SEMA6A in granule cell migration and tied the signal to centrosome-nucleus coupling, supplying the receptor missing from earlier loss-of-function work.

    Evidence Knockout and ENU binding-abrogating mutant, chimera studies, and time-lapse imaging of centrosome-nucleus coupling

    PMID:18327254

    Open questions at the time
    • Downstream cytoskeletal effectors of PlexinA2 not defined
    • Whether reverse signaling contributes to this phenotype not tested
  4. 2010 High

    Revealed that SEMA6A and PlexinA4 can interact in cis on the same cell to suppress trans-ligand binding, explaining how guidance responsiveness is tuned in a neuron-type-specific manner.

    Evidence Heterologous cis/trans binding assays plus sensory neuron collapse assays with SEMA6A knockout and PlexinA4 rescue

    PMID:20606624

    Open questions at the time
    • Structural basis of cis vs trans interaction not resolved
    • How the cis interaction is regulated developmentally unknown
  5. 2012 High

    Extended SEMA6A function to glial biology and adult CNS repair, showing it is an oligodendrocyte-derived PlexinA2-dependent inhibitor of axon growth and a requirement for myelination.

    Evidence In vitro sensory neuron inhibition with PlexinA2 KO, pyramidotomy axon-sprouting model, and oligodendrocyte/DRG co-culture myelination assays

    PMID:22564823 PMID:22777942

    Open questions at the time
    • Signaling pathway linking SEMA6A to myelination program not defined
    • Whether the axon-inhibitory and myelination roles share a mechanism unclear
  6. 2013 Medium

    Showed SEMA6A controls oligodendrocyte precursor migration through PlexinA4-mediated cell segregation, distinguishing a PlexinA4 receptor route in glial cells.

    Evidence siRNA knockdown in an OPC cell line with migration and co-culture segregation assays

    PMID:23376059

    Open questions at the time
    • Cell-line-based; not validated in primary OPCs in vivo
    • Intracellular signaling downstream not addressed
  7. 2014 High

    Generalized SEMA6A/PlexinA2 repulsion as a tissue-cohesion mechanism and refined its role to specific migration phases of later-born granule cells.

    Evidence Zebrafish morpholino knockdown with epistasis rescue and time-lapse imaging; cerebellar slice electroporation with live imaging in KO mice

    PMID:24917502 PMID:25284064

    Open questions at the time
    • Conservation of the cohesion mechanism in mammalian eye not directly tested
    • Effectors translating repulsion into cell positioning unknown
  8. 2015 Medium

    Implicated SEMA6A in cancer cell biology, showing it regulates actin cytoskeleton, anchorage-independent growth, and invasion downstream of BRAF signaling in melanoma.

    Evidence siRNA silencing and overexpression with cytoskeletal imaging and invasion/anchorage assays in melanoma lines

    PMID:25576923

    Open questions at the time
    • Receptor/signaling intermediary not yet identified in this study
    • Single-lab cell-line work without in vivo validation
  9. 2016 Medium

    Demonstrated SEMA6A/PlexinA2 control interkinetic nuclear migration in retinal progenitors, broadening the nuclear-migration role beyond cerebellum.

    Evidence Time-lapse videomicroscopy of embryonic retina in SEMA6A and PlexinA2 knockout mice

    PMID:27301906

    Open questions at the time
    • Molecular link to the nuclear migration machinery not defined
    • Forward vs reverse signaling contribution not separated
  10. 2017 Medium

    Established post-transcriptional control of SEMA6A by microRNAs and its role as a repulsive vascular signal, linking SEMA6A dosage to apoptosis in oral cancer and to pericyte recruitment in endothelium.

    Evidence Luciferase 3'-UTR reporter assays for miR-203 and miR-27b with overexpression/inhibition and pericyte adhesion rescue by SEMA6A silencing

    PMID:28453731 PMID:28982852

    Open questions at the time
    • Receptor mediating the pericyte repulsion not identified
    • Physiological relevance of miRNA regulation in vivo limited
  11. 2018 Medium

    Mapped SEMA6A to specific circuit wiring, showing it is required for accessory optic system axon projections from the MTN to the NOT.

    Evidence Cre-driver conditional analysis and axon tracing in SEMA6A null mice

    PMID:30076594

    Open questions at the time
    • Receptor and signaling direction not addressed
    • Whether defect is guidance vs fasciculation unresolved
  12. 2019 Medium

    Defined a SEMA6A/PlexinA2 forward-signaling cascade in osteoclastogenesis and identified upstream epigenetic repression of Sema6a by C11orf46/SETDB1 with relevance to transcallosal wiring.

    Evidence Fc-Sema6A pulldown with PLCγ/NFATc1 pathway dissection by inhibitor/neutralization; C11orf46 knockdown and dCas9-SunTag epigenetic editing with projection tracing

    PMID:30826495 PMID:31511512

    Open questions at the time
    • Direct C11orf46-Sema6a promoter binding not biochemically shown
    • Whether PLCγ/NFATc1 is engaged in neural contexts unknown
  13. 2023 High

    Connected SEMA6A to neuroendocrine physiology and human disease, and revealed an intracellular oncogenic role through SEC62 and Wnt/β-catenin.

    Evidence SEMA6A KO mouse GnRH/vascular permeability assays with PlexinA2 requirement and a human pathogenic variant; ChIP/reporter HIF-2α activation and SEMA6A-SEC62 Co-IP with xenografts in ccRCC

    PMID:36739418 PMID:38062045

    Open questions at the time
    • How SEMA6A-SEC62 binding stabilizes β-catenin mechanistically unresolved
    • Causality of the human SEMA6A variant beyond association not fully established
  14. 2024 Medium

    Genetically separated SEMA6A reverse signaling from forward signaling, showing the cytoplasmic domain is specifically required for retinal integrity, Müller glia function, and hippocampal mossy fiber partitioning.

    Evidence Zebrafish intracellular-domain-deletion rescue with retinal/Müller glia readouts; conditional neuronal KO and PlexinA2 GAP mutants with proximity proteomics and Plxna2/Ncam1 epistasis (preprint)

    PMID:38963001 PMID:bio_10.1101_2024.12.15.628586

    Open questions at the time
    • Intracellular effectors of reverse signaling in vivo not fully defined
    • Mossy fiber findings from a preprint not yet peer-reviewed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the cytoplasmic domain transduces reverse signaling into actin and transcriptional outputs, and how cells switch between cis-inhibitory, trans-forward, and reverse signaling modes, remains unresolved.
  • No structural model integrating cis/trans/reverse signaling states
  • Direct biochemical chain from cytoplasmic tail (EVL) to cytoskeletal/transcriptional output unmapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 4 GO:0008092 cytoskeletal protein binding 3 GO:0048018 receptor ligand activity 2
Localization
GO:0005886 plasma membrane 2
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-162582 Signal Transduction 4 R-HSA-1643685 Disease 3
Partners
EVLPLXNA2PLXNA4SEC62

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 SEMA6A-1 (SEMA6A) directly binds EVL (Ena/VASP-like protein) via a novel carboxyl-terminal zyxin-like domain; SEMA6A-1 colocalizes with EVL, and this interaction is selective (does not extend to other Ena/VASP family members Mena/VASP), suggesting a role for SEMA6A in retrograde signaling linked to actin/cytoskeletal dynamics. Yeast two-hybrid, pulldown/binding assay, colocalization in heterologous system; mutagenesis of the zyxin-like C-terminal domain The Journal of biological chemistry Medium 10993894
2005 Sema6A is required for cerebellar granule cell migration: Sema6A-deficient mice show ectopic granule cells remaining in the molecular layer, and analysis of chimeras demonstrates this function is primarily non-cell-autonomous. Sema6A controls initiation of radial migration, likely via modulation of nuclear/soma translocation. Knockout mouse analysis, mouse chimera studies, cerebellar explant migration and neurite outgrowth assays Nature neuroscience High 16205717
2008 PlexinA2 is the receptor for Sema6A in migrating cerebellar granule cells: PlexinA2-deficient mice phenocopy Sema6A mutants; an ENU-induced single amino acid substitution in the semaphorin-binding domain of PlexinA2 abolishes Sema6A binding; chimera studies show PlexinA2 acts cell-autonomously; Sema6A/PlexinA2 signaling controls nucleus-centrosome coupling and coordinated motility during migration. Homologous recombination knockout, ENU mutagenesis, binding assay (Sema6A–PlexinA2 interaction), mouse chimera studies, time-lapse video microscopy of centrosome–nucleus coupling Nature neuroscience High 18327254
2010 Sema6A engages in a cis interaction with its receptor PlexinA4 on the same cell surface, which inhibits binding of exogenous Sema6A ligand in trans and thereby suppresses the repulsive response. This cis Sema6A–PlexinA4 interaction differentially modulates axon guidance responsiveness in sympathetic vs. sensory neurons. Heterologous expression systems for cis/trans binding assays, sensory neuron collapse assays with Sema6A knockout (gain of sensitivity), PlexinA4-dependent rescue experiments The EMBO journal High 20606624
2012 Oligodendrocyte-expressed Sema6A inhibits adult axon growth via PlexinA2: adult sensory neurons are inhibited by Sema6A in a PlexinA2-dependent manner (complete protection in PlexinA2−/− cultures); PlexinA2−/− mice show enhanced corticospinal axon sprouting and improved functional recovery after pyramidotomy. In vitro sensory neuron inhibition assay with PlexinA2 KO, adult mouse pyramidotomy model with axonal sprouting quantification and behavioral testing Molecular and cellular neurosciences High 22564823
2012 Sema6A expressed by myelinating oligodendrocytes is required for oligodendrocyte differentiation and myelination: Sema6A-deficient mice show delayed oligodendrocyte differentiation, delayed node of Ranvier development, and reduced MBP expression. In vitro, Sema6A-null oligodendrocytes show morphological defects and impaired myelination in DRG co-culture. Knockout mouse analysis (optic nerve, anterior commissure), purified oligodendrocyte differentiation assay, myelinating co-culture with DRG neurons Glia High 22777942
2013 Sema6A expressed in oligodendrocyte precursor cells (OPCs) controls their autonomous migration via ligand-receptor interaction with PlexinA4 on surrounding cells: Sema6A knockdown in OPC line FBD-102b reduces migration, and Plexin-A4-expressing cells segregate from Sema6A-expressing cells in co-culture. siRNA knockdown in OPC cell line, in vitro migration assay, co-culture segregation assay, semaphorin gradient assay with PlexinA4 knockdown Neuroscience letters Medium 23376059
2014 Sema6A and PlexinA2 are required for eye vesicle cohesion in zebrafish: knockdown of either disrupts vesicle integrity, with eye progenitors failing to enter or delaminating from the eye epithelium. Epistasis (simultaneous knockdown of both) rescues vesicle integrity, placing Sema6A–PlexinA2-mediated repulsion as the mechanism maintaining tissue cohesion. Morpholino knockdown in zebrafish, time-lapse microscopy, explant experiments, double-knockdown epistasis rescue Development (Cambridge, England) High 24917502
2014 Time-lapse analysis of cerebellar slice electroporation confirms that Sema6A and PlexinA2 loss preferentially perturbs migration of later-born granule cells, and defects in tangential migration in bipolar granule cells precede the switch to radial migration; Sema6A loss does not perturb radial migration itself. Cerebellar slice model, in utero/ex vivo electroporation, time-lapse video microscopy in Sema6A and PlexinA2 knockout mice Molecular and cellular neurosciences Medium 25284064
2015 Sema6A silencing in BRAFV600E melanoma cells causes cytoskeletal remodeling with loss of stress fibers leading to cell death, loss of anchorage-independent growth, and inhibited chemotaxis/invasion; forced Sema6A overexpression in NRASQ61R cells induces anchorage-independent growth and invasiveness, indicating Sema6A regulates actin cytoskeleton and cell survival downstream of BRAF signaling. siRNA silencing, forced overexpression, cytoskeletal imaging, anchorage-independent growth assay, chemotaxis/invasion assay in melanoma cell lines Oncotarget Medium 25576923
2016 Sema6A/PlexinA2 signaling regulates interkinetic nuclear migration of retinal progenitor cells (RPCs): in Sema6A and PlexinA2 knockout mice, RPC migration is blocked at the apical side of the neuroblastic layer, as shown by time-lapse videomicroscopy. Knockout mouse analysis, time-lapse videomicroscopy of embryonic retina Development, growth & differentiation Medium 27301906
2017 SEMA6A is a direct target of miR-203: luciferase reporter assay confirmed miR-203 directly targets the SEMA6A 3'-UTR, suppressing SEMA6A mRNA and protein levels; miR-203-mediated SEMA6A downregulation promotes apoptosis in oral cancer cells. Luciferase 3'-UTR reporter assay, miRNA overexpression, Western blot, miRNA array Anticancer research Medium 28982852
2017 SEMA6A is repressed post-transcriptionally by miR-27b in endothelial cells; miR-27b overexpression represses SEMA6A (and SEMA6D), and silencing of SEMA6A rescues reduced pericyte adhesion caused by miR-27 inhibition, demonstrating that SEMA6A acts as a repulsive signal limiting pericyte recruitment. miR-27b overexpression/inhibition in endothelial cells, pericyte adhesion and co-culture assays, siRNA silencing of SEMA6A, in vivo LNA antisense oligonucleotide inhibition Cardiovascular research Medium 28453731
2018 Sema6A is required for formation of axonal projections from the medial terminal nucleus (MTN) to the nucleus of the optic tract (NOT) in the accessory optic system; using Cre-driver lines, Sema6A was shown to be necessary for establishing AOS connections in multiple locations. Conditional genetic approaches using Cre lines (Pcdh9-Cre, Pdzk1ip1-Cre), axon projection tracing in Sema6A null mice The Journal of comparative neurology Medium 30076594
2019 Sema6A-plexin-A2 axis stimulates RANKL-induced osteoclastogenesis via PLCγ-mediated NFATc1 activation: soluble Fc-Sema6A binds plexin-A2 in osteoclast cell lysates; Sema6A treatment enhances RANKL-induced osteoclast differentiation, an effect abolished by plexin-A2 neutralization; Sema6A-plexin-A2 enhances PLCγ activation and downstream NFATc1; pharmacological PLCγ inhibition (U73122) abrogates these effects. Fc-fusion protein pulldown/Co-IP, osteoclastogenesis differentiation assay, neutralizing antibody, pharmacological inhibitor (U73122), Western blot for PLCγ and NFATc1 activation Life sciences Medium 30826495
2019 C11orf46 (ARL14EP) represses Sema6A transcription via SETDB1-mediated repressive chromatin remodeling; C11orf46 haploinsufficiency leads to Sema6a hyperexpression and disrupted transcallosal projections; RNA-guided epigenetic editing (dCas9-SunTag with C11orf46) of Sema6a promoters normalized SEMA6A expression and rescued transcallosal dysconnectivity. C11orf46 knockdown, gene expression profiling, dCas9-SunTag epigenetic editing, chromatin remodeling assays, in vivo transcallosal projection tracing Nature communications Medium 31511512
2022 SEMA6A drives actin cytoskeleton remodeling in BRAF-mutant melanoma via RhoA-dependent YAP activation; SEMA6A depletion impairs the SEMA6A/RhoA/YAP axis; dual BRAF/MEK inhibition induces this axis, and SEMA6A depletion rescues efficacy of dabrafenib+trametinib in fibroblast co-culture conditions mimicking tumor microenvironment. Inducible SEMA6A silencing, RhoA and YAP activity assays, fibroblast-melanoma co-culture model, drug treatment experiments in vitro Journal of experimental & clinical cancer research : CR Medium 35440004
2023 SEMA6A is a direct target gene of HIF-2α in the VHL-HIF-2α axis in ccRCC: ChIP and reporter assays show HIF-2α directly activates SEMA6A transcription in hypoxia. SEMA6A physically interacts with SEC62 and promotes Wnt/β-catenin pathway activation through SEC62-dependent β-catenin stabilization; SEMA6A depletion impairs HIF-2α-induced Wnt/β-catenin activation and ccRCC cell proliferation in vitro and in vivo. ChIP assay, luciferase reporter assay, Co-immunoprecipitation (SEMA6A–SEC62 interaction), siRNA depletion, xenograft mouse model Cell death & disease Medium 36739418
2023 Semaphorin-6A, expressed by median eminence-resident oligodendrocytes adjacent to GnRH neuron projections, is required for GnRH neuron innervation and puberty onset; via its receptor Plexin-A2, Sema6A controls median eminence vascular permeability to maintain neuroendocrine homeostasis. A novel pathogenic variant of SEMA6A is identified in patients with delayed puberty. Sema6A KO mouse analysis, in vitro and in vivo vascular permeability assays, Plexin-A2 receptor requirement established, immunostaining, human genetic variant identification Nature communications High 38062045
2024 The intracellular (cytoplasmic) domain of Sema6A is required for retinal integrity, Müller glia end feet strength, and protection against retinal cell death in zebrafish, but is dispensable for eye size and retinal patterning; this distinguishes reverse signaling (requiring the intracellular domain) from forward signaling functions of Sema6A. Sema6A morphant rescue experiments in zebrafish with full-length Sema6A vs. intracellular domain-deleted Sema6A (Sema6A-ΔC); retinal histology, Müller glia analysis, cell death quantification Journal of cell science Medium 38963001
2024 Sema6A reverse signaling contributes to hippocampal mossy fiber partitioning into SPT and IPT bundles: loss of neuronal Sema6a causes defective MF patterning including incomplete IPT/SPT partition and overextended IPT axons; PlexinA2 controls MF fasciculation via both GAP-dependent and GAP-independent mechanisms, and a genetic interaction between Plxna2 and Ncam1 (but not Plxna4 and Ncam1) was identified for SPT/IPT formation. Conditional KO mouse lines (neuron-specific Sema6a), PlexinA2 GAP domain mutants, anti-PlexinA2 proximity biotinylation proteomics, double-KO genetic epistasis (Plxna2/Ncam1) bioRxivpreprint Medium bio_10.1101_2024.12.15.628586

Source papers

Stage 0 corpus · 27 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis. Arthritis and rheumatism 133 23740775
2008 Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells. Nature neuroscience 119 18327254
2005 The transmembrane semaphorin Sema6A controls cerebellar granule cell migration. Nature neuroscience 110 16205717
2010 Cis interaction between Semaphorin6A and Plexin-A4 modulates the repulsive response to Sema6A. The EMBO journal 74 20606624
2000 The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain. The Journal of biological chemistry 66 10993894
2015 Sema6A and Mical1 control cell growth and survival of BRAFV600E human melanoma cells. Oncotarget 57 25576923
2019 In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene. Nature communications 48 31511512
2012 Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination. Glia 45 22777942
2007 Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells. International journal of molecular medicine 40 17671748
2017 Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D. Cardiovascular research 36 28453731
2012 PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition. Molecular and cellular neurosciences 34 22564823
2014 Sema6a and Plxna2 mediate spatially regulated repulsion within the developing eye to promote eye vesicle cohesion. Development (Cambridge, England) 28 24917502
2018 Genetic access to neurons in the accessory optic system reveals a role for Sema6A in midbrain circuitry mediating motion perception. The Journal of comparative neurology 26 30076594
2017 Suppression of Oral Carcinoma Oncogenic Activity by microRNA-203 via Down-regulation of SEMA6A. Anticancer research 22 28982852
2022 SEMA6A/RhoA/YAP axis mediates tumor-stroma interactions and prevents response to dual BRAF/MEK inhibition in BRAF-mutant melanoma. Journal of experimental & clinical cancer research : CR 20 35440004
2020 Correlation of Long Noncoding RNA SEMA6A-AS1 Expression with Clinical Outcome in HBV-Related Hepatocellular Carcinoma. Clinical therapeutics 19 32070484
2016 PlexinA2 and Sema6A are required for retinal progenitor cell migration. Development, growth & differentiation 17 27301906
2006 The class 6 semaphorin SEMA6A is induced by interferon-gamma and defines an activation status of langerhans cells observed in pathological situations. The American journal of pathology 15 16436660
2023 SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability. Nature communications 14 38062045
2014 Time-lapse analysis of tangential migration in Sema6A and PlexinA2 knockouts. Molecular and cellular neurosciences 14 25284064
2013 A role of Sema6A expressed in oligodendrocyte precursor cells. Neuroscience letters 14 23376059
2023 VHL-HIF-2α axis-induced SEMA6A upregulation stabilized β-catenin to drive clear cell renal cell carcinoma progression. Cell death & disease 12 36739418
2023 LINC00312 Inhibits Lung Cancer Progression through the miR-3175/SEMA6A Axis. Critical reviews in eukaryotic gene expression 6 36734856
2019 Sema6A-plexin-A2 axis stimulates RANKL-induced osteoclastogenesis through PLCγ-mediated NFATc1 activation. Life sciences 5 30826495
2024 The intracellular domain of Sema6A is essential for development of the zebrafish retina. Journal of cell science 2 38963001
2025 SEMA6A overexpression inhibited tumor growth and metastasis in colorectal cancer. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 0 41259456
2023 Comprehensive Analysis to Identify LINC00511-hsa-miR-625-5p-SEMA6A Pathway Fuels Progression of Skin Cutaneous Melanoma. International journal of genomics 0 37434634

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