Affinage

SELENOP

Selenoprotein P · UniProt P49908

Length
381 aa
Mass
43.2 kDa
Annotated
2026-06-10
52 papers in source corpus 15 papers cited in narrative 15 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SELENOP (selenoprotein P) is a liver-secreted, selenium-rich extracellular protein that functions as the principal transport vehicle distributing selenium from hepatocytes to peripheral tissues and as a redox-active enzyme (PMID:23038251, PMID:24434121). Hepatocyte-specific deletion lowers plasma SELENOP to ~10% of normal, increases urinary selenium loss, and depletes selenium in extra-hepatic tissues, while hepatocyte-restricted transgenic expression of human SELENOP restores tissue selenium, selenoenzyme activity, fertility, and neurological function in Sepp-null mice — establishing liver-derived circulating SELENOP as the main selenium supply for brain, testis, kidney, and muscle (PMID:23038251, PMID:17961124). Peripheral uptake proceeds through apoER2 (LRP8)-mediated endocytosis that depends on heparan sulfate proteoglycan binding and on the selenium-rich C-terminal domain (residues 240–361), followed by lysosomal processing that liberates selenium for utilization (PMID:22761431). Beyond transport, the N-terminal domain carries a redox-active selenocysteine at position 40 within a thioredoxin-fold that confers thioredoxin reductase-1-coupled peroxidase activity, abolished by the U40S substitution (PMID:24434121). SELENOP is essential for survival of parvalbumin-expressing interneurons under limiting selenium, and its loss produces epileptic seizures, ataxia, and tremor that are prevented by selenium supplementation or transgenic SELENOP, a CNS requirement confirmed by a naturally occurring complete-deletion phenotype in dogs (PMID:36182809, PMID:34339417). SELENOP additionally engages signaling receptors: it binds the WNT co-receptors LRP5/6 to amplify canonical WNT signaling and promote intestinal tumorigenesis (PMID:37166989), and it signals through LRP8 on myeloid cells to shape anti-tumor immunity (PMID:39972392). Hepatic SELENOP expression is transcriptionally controlled, induced by lauric acid via HNF4α and repressed by AMPK downstream of GLP-1 receptor signaling (PMID:26194078, PMID:35499234).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2008 High

    Established that liver-derived circulating SELENOP, not local synthesis, is the form that supplies selenium to distant tissues, answering whether SELENOP acts systemically as a transport protein.

    Evidence Hepatocyte-specific transgenic human SEPP1 rescue in Sepp-/- mice with selenium, selenoenzyme, fertility, and neurological readouts

    PMID:17961124

    Open questions at the time
    • Did not define the receptor or uptake route in recipient tissues
    • Did not resolve which domain mediates delivery versus enzymatic function
  2. 2012 High

    Defined the hepatocyte as the obligatory source of plasma SELENOP and showed its role in organism-wide selenium retention and distribution.

    Evidence Hepatocyte-specific conditional Sepp1 knockout mice with plasma/urine/tissue selenium tracking

    PMID:23038251

    Open questions at the time
    • Did not address tissue uptake mechanism
    • Did not separate transport from enzymatic roles
  3. 2012 High

    Identified the cellular uptake mechanism, showing SELENOP is internalized via apoER2/LRP8 with heparan sulfate dependence and lysosomal processing of its C-terminal selenium-rich domain.

    Evidence 75Se uptake assays, apoER2/Lrp1 siRNA, receptor pulldown with MS, truncation mutants, lysosome acidification block in L8 myoblasts

    PMID:22761431

    Open questions at the time
    • Tested in one myoblast cell line
    • Did not establish tissue-specific receptor usage in vivo
  4. 2014 High

    Demonstrated that SELENOP is itself a redox enzyme, with an N-terminal selenocysteine (U40) conferring TrxR1-coupled peroxidase activity, separating its catalytic from its transport function.

    Evidence Purification of urinary N-terminal fragments, in vitro TrxR1 peroxidase assay, U40S active-site mutant

    PMID:24434121

    Open questions at the time
    • Physiological substrate and in vivo antioxidant role not defined
    • Significance of renal megalin-mediated fragment uptake unclear
  5. 2022 High

    Established a non-transport CNS requirement, showing SELENOP preserves parvalbumin interneuron survival and prevents seizures under limiting selenium.

    Evidence Constitutive Selenop KO with video-EEG, dose/timing selenium supplementation, hepatocyte-specific transgenic rescue, interneuron histology

    PMID:36182809

    Open questions at the time
    • Molecular basis of interneuron selectivity not resolved
    • Does not separate enzymatic from selenium-delivery contribution to neuroprotection
  6. 2021 Medium

    Confirmed in a large-animal model that SELENOP is required for selenium delivery to the CNS, generalizing the murine findings.

    Evidence Naturally occurring homozygous SELENOP deletion in dogs, WGS, selenium measurement, histopathology

    PMID:34339417

    Open questions at the time
    • Natural variant, not engineered control
    • Tissue uptake mechanism not directly examined
  7. 2023 High

    Revealed a signaling function distinct from selenium transport, showing SELENOP binds LRP5/6 to amplify canonical WNT signaling and drive colon tumorigenesis.

    Evidence Co-IP with LRP5/6, WNT reporter assays, tumor organoid rescue, Selenop×Apc intestinal KO mouse model, scRNA-seq

    PMID:37166989

    Open questions at the time
    • Whether selenocysteine/redox activity is needed for WNT effect unresolved
    • Binding interface on LRP5/6 not mapped
  8. 2025 Medium

    Linked post-translational acetylation of SELENOP to its expression and to LRP8-dependent modulation of myeloid cells in anti-tumor immunity.

    Evidence Co-IP of KAT8/SEPP1/LRP8, qRT-PCR/Western, flow cytometry, pancreatic cancer xenograft and metastasis models with anti-PD-1

    PMID:39972392

    Open questions at the time
    • K247/K249 acetylation not confirmed by site mutagenesis
    • Mechanism linking acetylation to transcription unclear
  9. 2022 Medium

    Defined transcriptional control of hepatic SELENOP, identifying HNF4α as a lauric-acid-induced activator and AMPK as a GLP-1-driven repressor.

    Evidence Luciferase promoter assay, ChIP, Hnf4α/Selenop siRNA in hepatocytes and mouse liver; AMPK siRNA epistasis and AICAR in HepG2 cells

    PMID:26194078 PMID:35499234

    Open questions at the time
    • FoxO1 contribution appears redundant and incompletely defined
    • Largely cell-line based; integration of opposing signals in vivo unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • How SELENOP's distinct activities — selenium transport, TrxR1-coupled peroxidase catalysis, and LRP5/6 and LRP8 receptor signaling — are coordinated and which require the selenocysteine remains unresolved.
  • No structural model integrating transport and signaling functions
  • Whether redox activity is required for WNT/immune signaling untested
  • Physiological enzymatic substrates undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140104 molecular carrier activity 3 GO:0060089 molecular transducer activity 2 GO:0016491 oxidoreductase activity 1
Localization
GO:0005576 extracellular region 3
Pathway
R-HSA-382551 Transport of small molecules 3 R-HSA-162582 Signal Transduction 1 R-HSA-168256 Immune System 1
Partners
KAT8LRP5LRP6LRP8TXNRD1

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2012 Hepatocyte-specific deletion of Sepp1 lowered plasma Sepp1 to ~10% of controls, increased urinary selenium excretion, and reduced selenium in extra-hepatic tissues, establishing that hepatocyte-produced Sepp1 is central to retaining selenium in the organism and distributing it from liver to peripheral tissues. Conditional knockout mouse (hepatocyte-specific Sepp1 deletion via alb-cre), selenium measurements in plasma/urine/tissues, mRNA quantification The Journal of biological chemistry High 23038251
2008 Transgenic hepatocyte-specific expression of human SELENOP in Sepp-/- mice restored selenium content and selenoenzyme activities in serum, kidney, testis, and brain, rescued male fertility and neurological defects under selenium-adequate diet, demonstrating that liver-derived circulating SePP is the main transport form supplying selenium to peripheral tissues including testis and brain. Transgenic rescue in Sepp-/- mice (hepatocyte-specific transthyretin promoter driving human SEPP1), selenium measurements, selenoenzyme activity assays, behavioral assessment The Biochemical journal High 17961124
2012 L8 myoblast cells take up Sepp1 via apoER2-mediated endocytosis requiring heparin sulfate proteoglycan binding; siRNA knockdown of apoER2 (but not Lrp1) inhibited 75Se uptake; blockage of lysosome acidification prevented Sepp1 digestion and selenium utilization; the selenium-rich C-terminal domain (residues 240-361) is required for uptake. 75Se-labeling uptake assays, siRNA knockdown of apoER2 and Lrp1, affinity chromatography (Sepp1 column) with mass spectrometry identification of receptors, protamine/chlorate inhibition, lysosome acidification blockage, truncation isoform comparison The Journal of biological chemistry High 22761431
2014 Urinary Sepp1 N-terminal fragments (Sepp1UF, residues 1-~183-208) possess peroxidase activity when coupled with thioredoxin reductase-1 (TrxR1), catalyzing NADPH oxidation with H2O2 or tert-butylhydroperoxide; activity requires the selenocysteine at position 40 (U40S mutant was inactive). Full-length Sepp1 and Sepp1Δ240-361 were also TrxR1 substrates. These fragments are filtered by the glomerulus and taken up by proximal convoluted tubule cells via megalin-mediated endocytosis. Purification of urinary Sepp1 forms from megalin-/- mice using monoclonal antibody, mass spectrometry identification of N-terminal fragments, in vitro TrxR1 peroxidase assay (NADPH oxidation), active-site mutant Sepp1(U40S) comparison Free radical biology & medicine High 24434121
2023 SELENOP interacts directly with the WNT co-receptors LRP5 and LRP6, and this protein-protein interaction contributes to SELENOP's ability to increase canonical WNT signaling activity; Selenop-KO tumor organoids showed decreased WNT target gene expression reversible by SELENOP restoration; Selenop KO in an intestinal APC-deletion mouse model decreased colon tumor incidence and size. Protein-protein interaction mapping (co-IP of SELENOP with LRP5/6), tumor organoid formation assay, WNT reporter assays in CRC and non-cancer cell lines, conditional KO mouse model (Selenop KO × Apc intestinal KO), scRNA-Seq of human colon tissue The Journal of clinical investigation High 37166989
2022 SELENOP is essential for preserving parvalbumin-expressing interneuron survival under limiting selenium supply; Selenop-/- mice on RDA diet developed epileptic seizures, ataxia, and tremor confirmed by video-EEG; selenium supplementation from birth or transgenic hepatocyte-specific human SELENOP expression prevented both neurological phenotypes; the effects were dose- and time-dependent. Constitutive Selenop knockout mice, video-electroencephalography, behavioral testing (ataxia/tremor scoring), selenium supplementation experiments (dose and timing variation), transgenic rescue (hepatocyte-specific SELENOP), brain GPx activity assay, histological analysis of interneurons Redox biology High 36182809
2025 KAT8 catalyzes acetylation of SEPP1 at lysine residues K247 and K249, upregulating SEPP1 transcription and protein level; SEPP1 then signals through its receptor LRP8 on MDSCs to impair MDSC survival, thereby enabling CD8+ T cell-mediated anti-tumor immunity in pancreatic cancer. Co-immunoprecipitation (Co-IP) of KAT8, SEPP1, and LRP8; qRT-PCR and Western blot; flow cytometry for immune cell abundance and apoptosis; PC xenograft and liver metastasis mouse models; SEPP1 recombinant protein treatment combined with anti-PD-1 Cell & bioscience Medium 39972392
2014 Exendin-4 (GLP-1 receptor agonist) reduces hepatic SEPP1 expression via AMPK activation; AMPK activator AICAR negatively regulated SEPP1 expression, and AMPK siRNA knockdown prevented the exendin-4-mediated reduction of SEPP1, placing AMPK upstream of SEPP1 expression in hepatocytes. HepG2 cell treatment with palmitic acid/tunicamycin ± exendin-4, AMPK siRNA knockdown, AICAR treatment, qRT-PCR and Western blotting for SEPP1 and ER stress markers Endocrinology and metabolism (Seoul, Korea) Medium 26194078
2022 Lauric acid upregulates Selenop expression in hepatocytes via HNF4α; luciferase promoter assay identified an HNF4α binding site in the SELENOP promoter; ChIP showed lauric acid increased HNF4α binding to this promoter; Hnf4α siRNA knockdown canceled lauric acid-induced Selenop upregulation; Akt phosphorylation impairment by lauric acid was rescued by knockdown of either Hnf4α or Selenop. Luciferase promoter assay, chromatin immunoprecipitation (ChIP), siRNA knockdown of Hnf4α and Selenop, Western blotting for Akt phosphorylation in Hepa1-6 cells and mouse liver American journal of physiology. Endocrinology and metabolism Medium 35499234
2022 FoxO1 knockdown accelerates EPA-mediated Selenop downregulation in hepatocytes independently of SREBP-1c; EPA upregulates Foxo1 mRNA via the ERK1/2 pathway without altering FoxO1 protein nuclear translocation, suggesting a redundant transcriptional network controlling Selenop expression. siRNA knockdown of Foxo1, ERK1/2 and PKA pharmacological inhibitors, RT-PCR, nuclear fractionation/translocation assay in H4IIEC3 hepatocytes Endocrine journal Medium 35321982
2021 SELENOP deletion in dogs (homozygous 17,325 bp deletion removing entire protein-coding sequence) caused cerebellar ataxia, CNS atrophy, and reduced blood selenium to ~30% of wildtype, demonstrating that SELENOP is required for selenium transport into the CNS in a large-animal model. Whole genome sequencing, linkage/homozygosity mapping, genotyping of >600 dogs, selenium measurement by atomic absorption, histopathology PLoS genetics Medium 34339417
2021 ZIKV infection knocked down SELENOP protein expression by ~99% in HEK293T cells without significant reduction in SELENOP mRNA, suggesting post-transcriptional/translational suppression; computationally predicted antisense hybridization between ZIKV RNA and SELENOP mRNA was confirmed at the DNA level by gel shift assay. ZIKV infection of HEK293T cells, Western blotting for SELENOP and TXNRD1, RT-qPCR for mRNA levels, gel shift assay with synthetic oligonucleotides BBA advances Low 34988542
2016 Overexpression of SEPP1 in 786-O and 769-P renal carcinoma cells inhibited proliferation, reduced colony formation, and caused G2/M cell cycle arrest in 786-O cells. Lentiviral overexpression of SEPP1, MTS proliferation assay, colony formation assay, flow cytometry cell cycle analysis Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology Low 27371843
2025 Hepatic Sepp1 depletion in HCC impairs selenium uptake in tumor-infiltrating neutrophils by disrupting Lrp8 receptor-mediated transport, suppressing intracellular selenium metabolism; this reduces hydrogen selenide (H2Se) production and increases S-adenosylmethionine (SAM) accumulation, leading to increased H3K4me3 modification in neutrophils and establishing a pro-senescence chromatin landscape that drives immunosuppression. scRNA-seq of HCC mouse tumors, macrophage/neutrophil-specific analyses, in vitro selenium uptake assays, chromatin modification (H3K4me3) measurement, selenium supplementation rescue experiments, anti-PD-1 combination therapy in mouse models bioRxivpreprint Low bio_10.1101_2025.06.24.661430
2024 Macrophage-specific deletion of Sepp1 impaired the acquisition of the repair inflammatory profile, disrupted macrophage support of muscle stem cells in vitro and in vivo, and caused inefficient skeletal muscle regeneration; transplantation of young WT (but not Sepp1 KO) bone marrow restored muscle regeneration in aged mice. Macrophage-specific Sepp1 conditional KO, FACS isolation of niche cells, RNA-sequencing, in vitro co-culture of macrophages and muscle stem cells, bone marrow transplantation into aged mice, in vivo regeneration assay bioRxivpreprint Low bio_10.1101_2024.08.28.610036

Source papers

Stage 0 corpus · 52 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 SEPP: SATé-enabled phylogenetic placement. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 198 22174280
2012 Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. The Journal of biological chemistry 117 23038251
2008 Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice. The Biochemical journal 113 17961124
2004 Expression profiling and genetic alterations of the selenoproteins GI-GPx and SePP in colorectal carcinogenesis. Nutrition and cancer 98 15203372
2020 lncRNA DLEU2 acts as a miR-181a sponge to regulate SEPP1 and inhibit skeletal muscle differentiation and regeneration. Aging 81 33221762
2012 Long isoform mouse selenoprotein P (Sepp1) supplies rat myoblast L8 cells with selenium via endocytosis mediated by heparin binding properties and apolipoprotein E receptor-2 (ApoER2). The Journal of biological chemistry 49 22761431
2013 Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics. Gene 43 24161883
2008 Expression of selenoprotein-coding genes SEPP1, SEP15 and hGPX1 in non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands) 39 19058871
2014 Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1. Free radical biology & medicine 35 24434121
2018 Arsenic metabolites; selenium; and AS3MT, MTHFR, AQP4, AQP9, SELENOP, INMT, and MT2A polymorphisms in Croatian-Slovenian population from PHIME-CROME study. Environmental research 34 30612060
2013 SEPP1 influences breast cancer risk among women with greater native american ancestry: the breast cancer health disparities study. PloS one 31 24278290
2020 Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components. Oxidative medicine and cellular longevity 29 32377302
2018 Correlations of SELENOF and SELENOP genotypes with serum selenium levels and prostate cancer. The Prostate 25 29314169
2016 Accurate Quantification of Selenoprotein P (SEPP1) in Plasma Using Isotopically Enriched Seleno-peptides and Species-Specific Isotope Dilution with HPLC Coupled to ICP-MS/MS. Analytical chemistry 19 27108743
2014 SEPP1 gene variants and abdominal aortic aneurysm: gene association in relation to metabolic risk factors and peripheral arterial disease coexistence. Scientific reports 19 25395084
2023 SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions. The Journal of clinical investigation 17 37166989
2021 Deletion of the SELENOP gene leads to CNS atrophy with cerebellar ataxia in dogs. PLoS genetics 17 34339417
2016 Selenium levels in human breast carcinoma tissue are associated with a common polymorphism in the gene for SELENOP (Selenoprotein P). Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 16 27908419
2022 High throughput drug screening identifies resveratrol as suppressor of hepatic SELENOP expression. Redox biology 15 36586222
2015 DNA damage and oxidative stress response to selenium yeast in the non-smoking individuals: a short-term supplementation trial with respect to GPX1 and SEPP1 polymorphism. European journal of nutrition 15 26658762
2014 Exendin-4 Inhibits the Expression of SEPP1 and Fetuin-A via Improvement of Palmitic Acid-Induced Endoplasmic Reticulum Stress by AMPK. Endocrinology and metabolism (Seoul, Korea) 15 26194078
2022 Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice. Redox biology 13 36182809
2018 Effects of selenium supplementation on expression of SEPP1 in mRNA and protein levels in subjects with and without metabolic syndrome suffering from coronary artery disease: Selenegene study a double-blind randomized controlled trial. Journal of cellular biochemistry 13 29932230
2017 SEPP1 polymorphisms modulate serum glucose and lipid response to Brazil nut supplementation. European journal of nutrition 13 28501922
2021 Coix lacryma-jobi Seed Oil Reduces Fat Accumulation in Nonalcoholic Fatty Liver Disease by Inhibiting the Activation of the p-AMPK/SePP1/apoER2 Pathway. Journal of oleo science 12 33840662
2018 The relationship between gestational diabetes mellitus and selenoprotein-P plasma 1 (SEPP1) gene polymorphisms. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 12 29648467
2022 Lauric acid impairs insulin-induced Akt phosphorylation by upregulating SELENOP expression via HNF4α induction. American journal of physiology. Endocrinology and metabolism 11 35499234
2019 HMGB1 and SEPP1 as predictors of hepatocellular carcinoma in patients with viral C hepatitis: Effect of DAAs. Clinical biochemistry 11 31158358
2022 An Assessment of GPX1 (rs1050450), DIO2 (rs225014) and SEPP1 (rs7579) Gene Polymorphisms in Women with Endometrial Cancer. Genes 9 35205233
2024 Bacteriophage vB_SepP_134 and Endolysin LysSte_134_1 as Potential Staphylococcus-Biofilm-Removing Biological Agents. Viruses 8 38543751
2016 Plasma Selenium Protein P Isoform 1 (SEPP1): A Predictor of Selenium Status in Nepalese Children Detected by Plasma Proteomics. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 8 27164173
2025 KAT8 catalyzes the acetylation of SEPP1 at lysine 247/249 and modulates the activity of CD8+ T cells via LRP8 to promote anti-tumor immunity in pancreatic cancer. Cell & bioscience 7 39972392
2024 Selenium promotes neural development through the regulation of GPX4 and SEPP1 in an iPSC-derived neuronal model. Biomaterials 6 39708777
2019 Effect of single nucleotide polymorphisms in SEPS1 and SEPP1 on expression in the protein level in metabolic syndrome in subjects with cardiovascular disease. Molecular biology reports 6 31542866
2021 Inhibition of selenoprotein synthesis by Zika virus may contribute to congenital Zika syndrome and microcephaly by mimicking SELENOP knockout and the genetic disease PCCA. BBA advances 5 34988542
2019 Evaluation of SEPP1 and Selenoprotein S Gene Polymorphisms (rs7579 and rs34713741) in Relation to Colorectal Cancer Susceptibility in Subset of Iranian Population: A Case-control Study. Advanced biomedical research 5 31523666
2018 Interaction of NKX3.1 and SELENOP genotype with prostate cancer recurrence. The Prostate 5 30582190
2022 The Association Between Selenium, Selenoprotein P (SEPP1), Fluid Intelligence, and Exercise in the UK Biobank Cohort. Cureus 4 35651983
2021 A Functional Variant in SEPP1 Interacts With Plasma Selenium Concentrations on 3-Year Lipid Changes: A Prospective Cohort Study. Frontiers in nutrition 4 34950691
2016 [Overexpression of SEPP1 inhibits the proliferation and induces cell cycle G2/M arrest of 786-O and 769-P human renal carcinoma cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 4 27371843
2014 Hypoxia induced changes of SePP1 expression in rat preadipocytes and its impact on vascular fibroblasts. International journal of clinical and experimental medicine 4 24482687
2022 Selenoprotein P-1 (SEPP1) as an Early Biomarker of Acute Kidney Injury in Patients Undergoing Cardiopulmonary Bypass. Reviews in cardiovascular medicine 3 39077596
2022 Forkhead box protein O1 (FoxO1) knockdown accelerates the eicosapentaenoic acid (EPA)-mediated Selenop downregulation independently of sterol regulatory element-binding protein-1c (SREBP-1c) in H4IIEC3 hepatocytes. Endocrine journal 2 35321982
2025 Integrated multi-omics analysis identifies SELENOP and PKMYT1 as immune-metabolic hub genes in breast cancer. Biochemistry and biophysics reports 1 40821907
2025 The SELENOP Polymorphism rs7579 Predicts Hepatic Steatosis in Females With Insulin Resistance in the General Population. Journal of the Endocrine Society 1 41001101
2024 Selenoprotein-P1 (SEPP1) Expression in Human Proximal Tubule Cells after Ischemia-Reperfusion Injury: An In Vitro Model. Medicina (Kaunas, Lithuania) 1 38929492
2026 Hypoxia-driven remodeling of SELENOP+ macrophages shapes T cell dynamics and promotes ovarian cancer metastasis. Nature communications 0 41526347
2026 Bioisostere-Driven Discovery of SePP: A Selenium-Containing Polypharmacological Agent Relevant to Fragile X Syndrome. Journal of medicinal chemistry 0 41666325
2026 Bone marrow SELENOP+ macrophages support hematopoiesis after transplantation via GAS6-AXL signaling pathway. Cancer letters 0 41862151
2025 Neurobehavioral effects of mercury, lead, and selenium co-exposure in the Brazilian amazon: Insights from bayesian mixture modeling and SELENOP genetic variation. Environmental toxicology and pharmacology 0 41371460
2024 Selenoprotein P-1 (SEPP1) as an Early Biomarker of Myocardial Injury in Patients Undergoing Cardiopulmonary Bypass. Journal of clinical medicine 0 38792487
2016 [Production effect comparison of SEPP and GPx between HepG2 and Hela cells with different selenocompounds]. Wei sheng yan jiu = Journal of hygiene research 0 27301226

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