Affinage

SELENOH

Selenoprotein H · UniProt Q8IZQ5

Length
122 aa
Mass
13.5 kDa
Annotated
2026-06-10
83 papers in source corpus 16 papers cited in narrative 15 extracted findings
Cross-family judge faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SELENOH is a nucleolar thioredoxin-like selenoprotein that defends the genome against oxidative damage and serves as a hub linking redox homeostasis to cell-cycle control, mitochondrial quality, and metabolic gene expression (PMID:17337453, PMID:25336634). It adopts a thioredoxin fold with a redox-active CXXU (selenocysteine) motif, displays glutathione peroxidase activity in vitro, and is targeted to nucleoli by an N-terminal RKRK signal whose mutation redirects the protein to the cytosol (PMID:17337453). Through this antioxidant function SELENOH suppresses cellular senescence: its loss elevates oxidative DNA damage and activates the ATM/p53 pathway (phospho-ATM, γH2AX), with senescence reversed by ATM inhibition, p53 depletion, low oxygen, or N-acetylcysteine, indicating specificity for oxidative rather than general DNA damage (PMID:25336634). Consistent with a genome-protective role, SELENOH restrains proliferation and migration and slows the G1/S transition in colorectal cancer cells, and its knockdown enhances tumor formation (PMID:29330096). SELENOH also governs mitochondrial homeostasis, binding mitochondrial carrier homolog 2 (MTCH2) to regulate mitofusin 2 (MFN2)-dependent fusion and quality control; its genetic loss in mice causes oxidative stress, impaired mitochondrial biogenesis, and enhanced mitophagy (PMID:41314281). Diverging from its redox role, SELENOH acts as a non-enzymatic scaffolding coactivator for ligand-activated PPARα, assembling and recruiting the PPARα–P300 complex to chromatin to drive hepatic fatty acid oxidation genes, a function disrupted in steatohepatitis and restored by selenium (PMID:41655241). SELENOH is the molecular target of the macrolide isovalerylspiramycin I (ISP I), which accelerates its degradation to provoke nucleolar oxidative stress and block RNA Polymerase I rRNA transcription via JNK2/TIF-IA signaling, triggering cancer cell apoptosis (PMID:35387667).

Mechanistic history

Synthesis pass · year-by-year structured walk · 7 steps
  1. 2007 High

    Established the core molecular identity of SELENOH: where it acts, what fold it has, and what enzymatic activity it carries, defining it as a nucleolar redox enzyme.

    Evidence Sequence/structure analysis, in vitro GPx assay with recombinant protein, GFP-fusion localization with RKRK mutagenesis, and shRNA knockdown + H2O2 sensitivity

    PMID:17337453 PMID:17503775

    Open questions at the time
    • Endogenous physiological substrate of the GPx activity not defined
    • Nucleolar targets of the oxidoreductase activity unidentified
  2. 2009 Medium

    Linked SELENOH abundance to mitochondrial protection, showing gain-of-function blocks the mitochondrial apoptotic pathway and supports biogenesis markers.

    Evidence Overexpression in HT22 neuronal cells with caspase/p53/NRF-1/PGC-1α/Tfam readouts and membrane-potential flow cytometry

    PMID:19766117 PMID:20656065

    Open questions at the time
    • Overexpression-only; physiological loss-of-function not tested here
    • Direct molecular link between SELENOH and biogenesis factors not established
  3. 2014 High

    Placed SELENOH in a defined genome-maintenance pathway, showing its loss drives oxidative DNA damage and ATM/p53-dependent senescence.

    Evidence shRNA knockdown in MRC-5/HeLa with senescence assays, phospho-ATM/γH2AX immunoblotting, ATM-inhibitor and p53-shRNA epistasis, oxygen tension and NAC rescue

    PMID:25336634

    Open questions at the time
    • How SELENOH connects nucleolar redox state to chromatin DNA damage not resolved
    • Whether the effect requires GPx catalytic activity untested
  4. 2018 High

    Demonstrated SELENOH is a cell-cycle and tumor suppressor, restraining G1/S progression and proliferation in vivo.

    Evidence shRNA knockdown in colorectal cancer cells with proliferation/migration/clonogenic assays, FACS cell-cycle analysis, and xenograft tumor models

    PMID:29330096

    Open questions at the time
    • Molecular effectors coupling SELENOH to G1/S machinery not identified
    • Relationship to the ATM/p53 senescence axis not directly tested
  5. 2022 High

    Identified SELENOH as the direct drug target of ISP I and showed its degradation triggers nucleolar stress and shutdown of rRNA transcription in cancer cells.

    Evidence DARTS + mass spectrometry target identification, ROS/R-loop/rRNA assays, JNK2/TIF-IA/POL I pathway analysis, and tumor models

    PMID:35387667

    Open questions at the time
    • Mechanism of ISP I-induced SELENOH degradation (protease/pathway) not defined
    • Why cancer cells are selectively sensitive not fully explained
  6. 2025 High

    Defined a physical and functional mitochondrial axis, showing SELENOH binds MTCH2 to regulate MFN2-dependent fusion and quality control.

    Evidence Co-IP + mass spectrometry, SELENOH knockout mice (cisplatin AKI), confocal imaging, molecular docking, and MTCH2 manipulation in HEK293t cells

    PMID:41314281

    Open questions at the time
    • Whether SELENOH redox activity is required for MTCH2 regulation unclear
    • Direct interaction interface not structurally validated
  7. 2026 High

    Revealed a non-redox scaffolding function, establishing SELENOH as a PPARα coactivator that assembles the PPARα-P300 complex on chromatin to drive hepatic fatty acid oxidation.

    Evidence Targeted screen, Co-IP/binding and chromatin recruitment assays, SELENOH KO mice, and dietary selenium rescue in a MASH model

    PMID:41655241

    Open questions at the time
    • How a redox-motif protein switches to a structural coactivator role mechanistically unresolved
    • Whether nucleolar localization is compatible with chromatin/PPARα recruitment not reconciled

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unknown how SELENOH's distinct activities—nucleolar redox scavenging, mitochondrial MTCH2 binding, and PPARα transcriptional coactivation—are integrated, and whether they share a common catalytic or structural requirement.
  • No structure of full-length SELENOH bound to a partner
  • Endogenous redox substrate still unidentified
  • Tissue-specific determinants of which function dominates unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016491 oxidoreductase activity 2 GO:0060090 molecular adaptor activity 1 GO:0140110 transcription regulator activity 1
Localization
GO:0005634 nucleus 2 GO:0005730 nucleolus 1
Pathway
R-HSA-8953897 Cellular responses to stimuli 2 R-HSA-1430728 Metabolism 1 R-HSA-1640170 Cell Cycle 1
Partners
MFN2MTCH2PPARA

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 SELENOH (SelH) is a nucleolar thioredoxin-like oxidoreductase. Sequence/structure analysis identified a thioredoxin fold with a conserved CXXU motif. Recombinant SelH showed glutathione peroxidase activity in vitro. GFP-fusion experiments localized full-length SelH to nucleoli in transfected mammalian cells; mutations in the N-terminal RKRK motif redirected the protein to the cytosol. SelH knockdown in LCC1 cells increased sensitivity to hydrogen peroxide, establishing a functional role in oxidative stress defense. Sequence/structure analysis, in vitro GPx activity assay with recombinant protein, GFP-fusion localization in transfected cells, RKRK motif mutagenesis, shRNA knockdown + H2O2 sensitivity assay The Journal of biological chemistry High 17337453
2007 SelH belongs to the Rdx (thioredoxin-like) protein family, which also includes SelW, SelV, SelT, and Rdx12. The family is proposed to possess a thioredoxin-like fold with a conserved CxxC/CxxU redox motif. GFP-fusion experiments showed distinct subcellular localization patterns for each family member in transfected cells. Affinity column experiments using mutant Rdx12 identified glutathione peroxidase 1 as an interacting target of Rdx12; 14-3-3 protein was identified as a target of SelW. Sequence similarity searches, GFP-fusion subcellular localization, affinity column pulldown with mutant protein versions Biochemistry Medium 17503775
2014 SelH suppresses cellular senescence in human fibroblasts (MRC-5) through a genome maintenance pathway. SelH shRNA knockdown under ambient O2 induced senescence markers (β-galactosidase, autofluorescence, growth inhibition) and activated the ATM/p53 pathway (phospho-ATM Ser-1981, γH2AX). Senescence phenotypes were rescued by ATM kinase inhibitors, p53 shRNA, or 3% O2. SelH shRNA HeLa cells were hypersensitive to paraquat and H2O2 (but not to hydroxyurea, neocarzinostatin, or camptothecin), indicating specificity for oxidative DNA damage. Glutathione levels were lower in SelH knockdown cells; H2O2-induced death was rescued by N-acetylcysteine. shRNA knockdown, β-galactosidase/autofluorescence senescence assays, immunoblotting for phospho-ATM and γH2AX, clonogenic survival assays, ATM inhibitor and p53 shRNA epistasis, glutathione measurement, NAC rescue The Journal of biological chemistry High 25336634
2010 Overexpression of human SELENOH in murine hippocampal HT22 neuronal cells promotes mitochondrial biogenesis by increasing levels of NRF-1, PGC-1α, and Tfam. Mitochondrial cytochrome c content, mass, and respiration were elevated. SelH overexpression ameliorated UVB-induced suppression of mitochondrial biogenesis markers and prevented mitochondrial membrane depolarization. Stable transfection/overexpression in HT22 cells, immunoblotting for NRF-1/PGC-1α/Tfam/cytochrome c, mitochondrial mass and respiration assays, flow cytometry for membrane potential Mitochondrion Medium 20656065
2009 Overexpression of SELENOH in HT22 neuronal cells protected against UVB-induced death by blocking the mitochondrial apoptotic pathway: it prevented mitochondrial membrane depolarization, suppressed p53 induction, and reduced caspase-3 and -9 activation. SelH overexpression also increased NRF-1 and HSP40 levels. Transfection/overexpression, cell viability assays, immunoblotting for caspases/AIF/p53/NRF-1/HSP40, flow cytometry for mitochondrial membrane potential Experimental neurology Medium 19766117
2018 SELENOH knockdown in human colorectal cancer cells decreased cellular differentiation, increased proliferation and migration, enhanced clonogenic and xenograft tumor-forming ability, and accelerated G1/S cell cycle transition, establishing SELENOH as a regulator of cell cycle progression and an inhibitor of uncontrolled proliferation. shRNA knockdown, cell proliferation/migration assays, colony formation, xenograft tumor models, cell cycle analysis (FACS) Free radical biology & medicine High 29330096
2017 Overexpression of SELENOH in HT22 cells protected against glutamate-induced cytotoxicity by preserving mitochondrial dynamics (preventing excessive fission) and suppressing autophagy. Glutamate-induced increases in ROS production and mitochondrial dynamic imbalance were reversed by SelH overexpression. Transfection/overexpression in HT22 cells, ROS measurement, mitochondrial morphology imaging, autophagy markers International journal of biological sciences Medium 29535592
2022 Isovalerylspiramycin I (ISP I) targets SELENOH (identified by DARTS and mass spectrometry). ISP I treatment accelerates SelH degradation, causing ROS accumulation in the nucleolus, triggering nucleolar stress, blocking ribosomal RNA transcription via the JNK2/TIF-IA/RNA Polymerase I pathway, and causing R-loop formation, DNA damage, cell cycle arrest, and apoptosis specifically in cancer cells. DARTS (drug affinity responsive target stability) + mass spectrometry for target ID, ROS assays, R-loop detection, rRNA transcription assays, JNK2/TIF-IA/POLI pathway analysis, cancer cell and tumor models Journal of experimental & clinical cancer research : CR High 35387667
2018 Computational modeling (homology modeling, MD simulation, and docking) of SELENOH showed that the selenocysteine residue in the CXXU motif dynamically stabilizes protein structure via intramolecular hydrogen bonding and residue contacts. The N-terminal PRGRKRK motif (positions 3–9) was predicted to interact with HSE and STRE DNA elements (consistent with prior experimental localization data), and functions as both an AT-hook motif and a nuclear localization signal. Mutation of Sec-44 to Cys destabilized the structure. Homology modeling, molecular dynamics simulation, molecular docking with DNA elements, mutant analysis (Sec→Cys substitution) Amino acids Low 29480333
2012 Delta-lactoferrin (ΔLf), a transcription factor, activates transcription from the SelH promoter via a ΔLf response element. ΔLf was shown experimentally to interact in vivo with the SelH promoter, establishing SelH as a direct transcriptional target of ΔLf. Transcriptional reporter assays, chromatin immunoprecipitation/in vivo promoter interaction Biochemistry and cell biology Medium 22320386
2014 In the Wilson's disease mouse model (Atp7b−/−), the nucleus-localized glutathione reductase/oxidoreductase SelH is upregulated in hepatic nuclei, likely to maintain redox balance in response to elevated copper accumulation, as demonstrated by quantitative nuclear proteomics. Quantitative MuDPIT nuclear proteomics (mass spectrometry-based), ionomics Journal of molecular biology / Metallomics Medium 21146535 22565294
2021 SELENOH overexpression in 293T cells identified two protein isoforms (long and short) by anti-FLAG immunoblotting and LC-MS/MS. Co-immunoprecipitation of FLAG-SELENOH co-identified three 60S ribosomal proteins and 9 other proteins as interactors. Overexpression of FLAG-SELENOH reduced glutathione peroxidase 1 and thioredoxin reductase 1 protein (but not mRNA) levels in selenium insufficiency, suggesting competition for selenoprotein biosynthesis machinery. FLAG-tag immunoprecipitation, LC-MS/MS, immunoblotting, qRT-PCR, transient transfection The Journal of nutrition Medium 34510207
2025 SELENOH targets mitochondrial carrier homolog 2 (MTCH2), identified by co-immunoprecipitation combined with mass spectrometry. SelH knockout in mice caused oxidative stress, impaired mitochondrial biogenesis, disrupted mitochondrial dynamics, enhanced mitophagy, and promoted apoptosis in kidneys. In HEK293t cells, SelH overexpression regulated MFN2 (mitofusin 2) via MTCH2 to promote mitochondrial fusion and maintain mitochondrial quality control homeostasis. Co-IP + mass spectrometry for MTCH2 identification, SelH knockout mice (cisplatin AKI model), laser confocal microscopy, molecular docking, MTCH2 knockdown/overexpression in HEK293t cells, oxidative stress/mitophagy/apoptosis assays Journal of advanced research High 41314281
2024 Selenoh gene knockout (HKO) in mice caused significant cognitive decline associated with reduced myelin basic protein expression in hippocampal oligodendrocytes, decreased glycolipid levels, and increased phospholipid and sphingolipid levels in the hippocampus. RNA-seq of HKO hippocampus showed downregulation of myelination pathways, confirmed by reduced myelin-related protein expression. HKO increased expression of hippocampal fatty acid transporter (FATP) 4. Selenoh knockout mouse model, behavioral cognition tests, RNA-seq, immunoblotting for myelin proteins, lipidomics Food & function High 39072440
2026 SELENOH functions as a transcriptional coactivator (scaffolding, non-redox role) for the nuclear receptor PPARα to regulate hepatic fatty acid oxidation (FAO). SELENOH binds ligand-activated PPARα and orchestrates assembly and chromatin recruitment of the PPARα-P300 transactivation complex, driving FAO gene expression. This function is disrupted in metabolic dysfunction-associated steatohepatitis (MASH) due to SELENOH deficiency but reconstituted by selenium supplementation. Targeted screen, Co-IP/binding assays, chromatin recruitment assays, SELENOH KO mouse model, dietary selenium supplementation, FAO gene expression analysis Advanced science High 41655241

Source papers

Stage 0 corpus · 83 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects. Birth defects research. Part A, Clinical and molecular teratology 250 17177317
2016 Selenoprotein Gene Nomenclature. The Journal of biological chemistry 223 27645994
2000 Mouse models for neural tube closure defects. Human molecular genetics 219 10767323
2020 Role of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review. Antioxidants (Basel, Switzerland) 185 32380763
2007 SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. Biochemistry 164 17503775
2009 Selenium status highly regulates selenoprotein mRNA levels for only a subset of the selenoproteins in the selenoproteome. Bioscience reports 155 19076066
2012 A high-selenium diet induces insulin resistance in gestating rats and their offspring. Free radical biology & medicine 104 22342560
1999 Mini-review: toward understanding mechanisms of genetic neural tube defects in mice. Teratology 102 10525207
2007 Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. The Journal of biological chemistry 97 17337453
2015 Selenoproteins protect against avian nutritional muscular dystrophy by metabolizing peroxides and regulating redox/apoptotic signaling. Free radical biology & medicine 78 25668720
2005 Recoding elements located adjacent to a subset of eukaryal selenocysteine-specifying UGA codons. The EMBO journal 71 15791204
2023 Selenomethionine alleviates environmental heat stress induced hepatic lipid accumulation and glycogen infiltration of broilers via maintaining mitochondrial and endoplasmic reticulum homeostasis. Redox biology 50 37797371
2003 Structure and expression of mobile ETnII retroelements and their coding-competent MusD relatives in the mouse. Journal of virology 47 14557630
2015 Selenium Deficiency Downregulates Selenoproteins and Suppresses Immune Function in Chicken Thymus. Biological trace element research 46 25739540
2018 Selenoprotein H controls cell cycle progression and proliferation of human colorectal cancer cells. Free radical biology & medicine 41 29330096
2018 Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer. Nutrients 40 30469315
2014 Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation. The Journal of biological chemistry 40 25336634
2017 Analyses of Selenotranscriptomes and Selenium Concentrations in Response to Dietary Selenium Deficiency and Age Reveal Common and Distinct Patterns by Tissue and Sex in Telomere-Dysfunctional Mice. The Journal of nutrition 39 28855418
2010 Upregulation of human selenoprotein H in murine hippocampal neuronal cells promotes mitochondrial biogenesis and functional performance. Mitochondrion 38 20656065
2009 Insights into prevention of human neural tube defects by folic acid arising from consideration of mouse mutants. Birth defects research. Part A, Clinical and molecular teratology 38 19117321
1989 Genetic analysis of the cause of exencephaly in the SELH/Bc mouse stock. Teratology 37 2814901
2012 Genetic variation in selenoprotein genes, lifestyle, and risk of colon and rectal cancer. PloS one 34 22615972
2010 Elevated copper remodels hepatic RNA processing machinery in the mouse model of Wilson's disease. Journal of molecular biology 30 21146535
2018 Polyphenol extracts from dried sugarcane inhibit inflammatory mediators in an in vitro colon cancer model. Journal of proteomics 29 29432917
2016 Response of Selenium and Selenogenome in Immune Tissues to LPS-Induced Inflammatory Reactions in Pigs. Biological trace element research 29 27726062
2012 Delta-lactoferrin, an intracellular lactoferrin isoform that acts as a transcription factor. Biochemistry and cell biology = Biochimie et biologie cellulaire 29 22320386
2011 Marginal selenium deficiency down-regulates inflammation-related genes in splenic leukocytes of the mouse. The Journal of nutritional biochemistry 29 22137268
2001 Multifactorial genetics of exencephaly in SELH/Bc mice. Teratology 29 11598925
2015 Selenium Deficiency Affects the mRNA Expression of Inflammatory Factors and Selenoprotein Genes in the Kidneys of Broiler Chicks. Biological trace element research 28 26400650
2012 A systems approach implicates nuclear receptor targeting in the Atp7b(-/-) mouse model of Wilson's disease. Metallomics : integrated biometal science 27 22565294
2015 Effects of Dietary Selenium Against Lead Toxicity on mRNA Levels of 25 Selenoprotein Genes in the Cartilage Tissue of Broiler Chicken. Biological trace element research 26 26643179
2009 Overexpression of human selenoprotein H in neuronal cells ameliorates ultraviolet irradiation-induced damage by modulating cell signaling pathways. Experimental neurology 25 19766117
2022 Targeting selenoprotein H in the nucleolus suppresses tumors and metastases by Isovalerylspiramycin I. Journal of experimental & clinical cancer research : CR 24 35387667
2017 Pharmacogenomic Characterization and Isobologram Analysis of the Combination of Ascorbic Acid and Curcumin-Two Main Metabolites of Curcuma longa-in Cancer Cells. Frontiers in pharmacology 24 28210221
2015 Selenoproteins and heat shock proteins play important roles in immunosuppression in the bursa of Fabricius of chickens with selenium deficiency. Cell stress & chaperones 24 26228634
2013 Porcine serum can be biofortified with selenium to inhibit proliferation of three types of human cancer cells. The Journal of nutrition 24 23677865
2016 Selenoprotein Transcript Level and Enzyme Activity as Biomarkers for Selenium Status and Selenium Requirements in the Turkey (Meleagris gallopavo). PloS one 23 27008545
2024 Se Alleviated Pb-Caused Neurotoxicity in Chickens: SPS2-GPx1-GSH-IL-2/IL-17-NO Pathway, Selenoprotein Suppression, Oxidative Stress, and Inflammatory Injury. Antioxidants (Basel, Switzerland) 22 38539903
2019 Selenomethionine relieves inflammation in the chicken trachea caused by LPS though inhibiting the NF-κB pathway. Biological trace element research 22 31325027
2017 Selenium accelerates chicken dendritic cells differentiation and affects selenoproteins expression. Developmental and comparative immunology 21 28735963
2018 Selenium regulation of selenoprotein enzyme activity and transcripts in a pilot study with Founder strains from the Collaborative Cross. PloS one 20 29338053
2017 Selenium against lead-induced apoptosis in chicken nervous tissues via mitochondrial pathway. Oncotarget 20 29296229
2024 Molecular mechanism of selenium against lead-induced apoptosis in chicken brainstem relating to heat shock protein, selenoproteins, and inflammatory cytokines. Ecotoxicology and environmental safety 19 38310824
2021 Determination of optimal dietary selenium levels by full expression of selenoproteins in various tissues of broilers from 1 to 21 d of age. Animal nutrition (Zhongguo xu mu shou yi xue hui) 18 34754955
2020 Selenium(Ⅳ) alleviates chromium(Ⅵ)-induced toxicity in the green alga Chlamydomonas reinhardtii. Environmental pollution (Barking, Essex : 1987) 18 33433342
2018 Selenium Pretreatment Alleviated LPS-Induced Immunological Stress Via Upregulation of Several Selenoprotein Encoding Genes in Murine RAW264.7 Cells. Biological trace element research 17 29671252
2018 The Thioredoxin-Like Family of Selenoproteins: Implications in Aging and Age-Related Degeneration. Biological trace element research 17 30229511
2021 Selenium Deficiency Induces Apoptosis and Necroptosis Through ROS/MAPK Signal in Human Uterine Smooth Muscle Cells. Biological trace element research 16 34480665
2017 Analysis of the Interactions Between Thioredoxin and 20 Selenoproteins in Chicken. Biological trace element research 16 28251482
2015 Expression of Selenoprotein Genes Is Affected by Heat Stress in IPEC-J2 Cells. Biological trace element research 16 26706036
2014 SILAC-based proteomic profiling of the human MDA-MB-231 metastatic breast cancer cell line in response to the two antitumoral lactoferrin isoforms: the secreted lactoferrin and the intracellular delta-lactoferrin. PloS one 16 25116916
2017 Overexpression of selenoprotein H prevents mitochondrial dynamic imbalance induced by glutamate exposure. International journal of biological sciences 14 29535592
2016 Expression of human selenoprotein genes selh, selk, selm, sels, selv, and gpx-6 in various tumor cell lines. Doklady. Biochemistry and biophysics 14 27417721
1992 Further genetic studies of the cause of exencephaly in SELH mice. Teratology 13 1412061
2022 Selenoprotein Gene mRNA Expression Evaluation During Renal Ischemia-Reperfusion Injury in Rats and Ebselen Intervention Effects. Biological trace element research 12 35553364
2021 Yeast Selenium Exerts an Antioxidant Effect by Regulating the Level of Selenoprotein to Antagonize Cd-Induced Pyroptosis of Chicken Liver. Biological trace element research 12 34716536
2021 Determination of optimal dietary selenium levels by full expression of selenoproteins in various tissues of broilers from 22 to 42 d of age. Animal nutrition (Zhongguo xu mu shou yi xue hui) 12 34977372
2015 Selenoprotein Genes Exhibit Differential Expression Patterns Between Hepatoma HepG2 and Normal Hepatocytes LO2 Cell Lines. Biological trace element research 12 25846212
2010 Use of stringent selection parameters for the identification of possible selenium-responsive marker genes in mouse liver and gastrocnemius. Biological trace element research 11 21080100
2022 Macranthoidin B (MB) Promotes Oxidative Stress-Induced Inhibiting of Hepa1-6 Cell Proliferation via Selenoprotein. Biological trace element research 10 35080709
2018 Selenocysteine-Mediated Expressed Protein Ligation of SELENOM. Methods in molecular biology (Clifton, N.J.) 10 28917051
2018 Characterization of structural and functional role of selenocysteine in selenoprotein H and its impact on DNA binding. Amino acids 10 29480333
2017 Glutathione Peroxidase 1, Selenoprotein K, and Selenoprotein H May Play Important Roles in Chicken Testes in Response to Selenium Deficiency. Biological trace element research 10 28190185
2023 Carrimycin, a first in-class anti-cancer agent, targets selenoprotein H to induce nucleolar oxidative stress and inhibit ribosome biogenesis. Cancer pathogenesis and therapy 9 37750087
1994 Three spontaneous mutations at the albino locus in SELH/Bc mice. Genome 8 8200511
1993 Ataxia and a cerebellar defect in the exencephaly-prone SELH/Bc mouse stock. Teratology 8 8322227
2021 Selenoproteins Protect Against Avian Liver Necrosis by Metabolizing Peroxides and Regulating Receptor Interacting Serine Threonine Kinase 1/Receptor Interacting Serine Threonine Kinase 3/Mixed Lineage Kinase Domain-Like and Mitogen-Activated Protein Kinase Signaling. Frontiers in physiology 7 34456747
2022 Revealing the intratumoral heterogeneity of non-DS acute megakaryoblastic leukemia in single-cell resolution. Frontiers in oncology 6 36003795
2000 Whiskers amiss, a new vibrissae and hair mutation near the Krt1 cluster on mouse chromosome 11. Mammalian genome : official journal of the International Mammalian Genome Society 6 10754100
1988 Cleft palate: more genetic lessons from mice. Journal of craniofacial genetics and developmental biology 6 3182968
2022 Fish Oil and Selenium with Doxorubicin Modulates Expression of Fatty Acid Receptors and Selenoproteins, and Targets Multiple Anti-Cancer Signaling in Triple-negative Breast Cancer Tumors. International journal of medical sciences 5 36483592
2021 Identification of Selenoprotein H Isoforms and Impact of Selenoprotein H Overexpression on Protein But Not mRNA Levels of 2 Other Selenoproteins in 293T Cells. The Journal of nutrition 5 34510207
2010 [Correlation of the methylation status of CpG islands in the promoter region of 10 genes with the 5-Fu chemosensitivity in 3 breast cancer cell lines]. Zhonghua zhong liu za zhi [Chinese journal of oncology] 4 20723428
1996 Exencephaly and cleft cerebellum in SELH/Bc mouse embryos are alternative developmental consequences of the same underlying genetic defect. Teratology 4 9035344
2025 Selenium exposure on breast cancer risk and progression: Comprehensive analysis identifies MSRB1 as a novel therapeutic target. Ecotoxicology and environmental safety 3 40700964
2024 Selenoprotein H mediates low selenium-related cognitive decline through impaired oligodendrocyte myelination with disrupted hippocampal lipid metabolism in female mice. Food & function 3 39072440
2024 Alleviation of Lipid Disorder and Liver Damage in High-Fat Diet-Induced Obese Mice by Selenium-Enriched Cardamine violifolia with Cadmium Accumulation. Nutrients 3 39339808
2024 RNA sequencing comparing centenarian and middle-aged women lymphoblastoid cell lines identifies age-related dysregulated expression of genes encoding selenoproteins, heat shock proteins, CD99, and BID. Drug development research 3 39445501
2023 Characterization and tissue expression of twelve selenoproteins in yellow catfish Pelteobagrus fulvidraco fed diets varying in oxidized fish oil and selenium levels. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2 37244044
1992 Studies of a spontaneous lethal mutation at the albino locus in SELH/Bc mice. Genome 2 1618394
2025 Selenoprotein H targets MTCH2 to regulate MFN2-dependent mitochondrial quality control to alleviate acute kidney injury. Journal of advanced research 1 41314281
2026 Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 0 41655241
2026 Current Advances in the Physiological Roles of the Thioredoxin-Like Family of Selenoproteins. Biological trace element research 0 42207467

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