Affinage

SEC23IP

SEC23-interacting protein · UniProt Q9Y6Y8

Round 2 corrected
Length
1000 aa
Mass
111.1 kDa
Annotated
2026-04-28
88 papers in source corpus 9 papers cited in narrative 9 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SEC23IP (p125A) is a COPII accessory protein that organizes ER exit sites and facilitates ER-to-Golgi transport, with particular importance for large cargo secretion and acrosome biogenesis. It binds Sec23 via an N-terminal proline-rich region and Sec31 via a central domain (residues 260–600), forming preassembled Sec13/Sec31A/SEC23IP heterohexamers that promote outer COPII coat assembly, while simultaneously engaging PI4P-containing acceptor membranes to stabilize donor–acceptor membrane apposition required for tunnel-based collagen transport (PMID:10400679, PMID:20679433, PMID:40463098). SEC23IP also functions as an adaptor for VPS13B/COH1 at the ERES–ERGIC interface, and loss of this interaction blocks tubular ERGIC formation and delays procollagen export, linking it mechanistically to Cohen syndrome pathology (PMID:39352497). Knockout mice reveal an essential in vivo role in acrosome formation during spermiogenesis, with males producing round-headed, acrosome-less sperm and exhibiting subfertility (PMID:21640725).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 1999 High

    The discovery of p125 as a novel Sec23-interacting protein distinct from Sec24 established that mammalian COPII vesicle formation involves additional regulatory partners beyond the conserved yeast components.

    Evidence GST-Sec23p pulldown from mammalian cells, yeast two-hybrid confirmation of proline-rich region binding, overexpression phenotype disrupting ERGIC/Golgi

    PMID:10400679

    Open questions at the time
    • Endogenous lipase activity of p125 not determined
    • Binding stoichiometry with Sec23 unknown
    • No loss-of-function data
  2. 2002 Medium

    Characterization of a p125 paralog (KIAA0725p) with phospholipase A1 activity but lacking the Sec23-binding region showed that the lipase homology domain and COPII-binding functions are separable, raising the question of whether p125 itself possesses enzymatic activity.

    Evidence In vitro phospholipase A1 assay on paralog, in vitro binding showing paralog does not bind Sec23p

    PMID:11788596

    Open questions at the time
    • Whether p125 retains catalytic lipase activity remains untested in this study
    • Functional redundancy between p125 and paralog unexplored
  3. 2004 High

    Localization of p125 to ER exit sites by electron microscopy and demonstration that its depletion disorganizes ERES and cis-Golgi architecture established p125 as a structural organizer of COPII budding sites, rather than merely a Sec23 binding partner.

    Evidence Immunofluorescence and electron microscopy localization, chimeric domain-swap analysis, RNAi knockdown with organelle morphology readout

    PMID:15623529

    Open questions at the time
    • Mechanism by which p125 organizes ERES not resolved
    • Whether cargo export is affected remained unclear at this stage
  4. 2010 High

    The finding that p125A binds Sec31A (residues 260–600) and exists as preassembled cytosolic Sec13/Sec31A/p125A heterohexamers revealed that p125A is an integral component of the outer COPII coat complex, not merely a Sec23 accessory factor.

    Evidence Co-immunoprecipitation, gel filtration, immunodepletion of cytosolic complexes, RNAi with ER export and Golgi morphology readouts

    PMID:20679433

    Open questions at the time
    • Structural basis of ternary complex unknown
    • Whether p125A binding to Sec31 and Sec23 is simultaneous or sequential was unresolved
  5. 2011 High

    Knockout mice demonstrated that Sec23ip is dispensable for general viability but essential for acrosome biogenesis during spermiogenesis, revealing a specialized in vivo cargo-trafficking role.

    Evidence Gene knockout mouse model with histological and morphological sperm analysis

    PMID:21640725

    Open questions at the time
    • Which specific cargo trafficking step in acrosome biogenesis requires Sec23ip is unknown
    • Whether other specialized secretory tissues are affected remains unexplored
  6. 2020 Medium

    Identification of Sec23ip in the 14-3-3γ interactome of Leydig cells and its requirement for cholesterol mobilization during steroidogenesis extended its trafficking roles beyond canonical ER-to-Golgi transport.

    Evidence LC-MS co-IP proteomics with 14-3-3γ, siRNA knockdown with steroidogenesis and cholesterol trafficking assays in MA-10 cells

    PMID:31875919

    Open questions at the time
    • Direct physical interaction between Sec23ip and 14-3-3γ not validated by reciprocal methods
    • Mechanism of cholesterol trafficking contribution uncharacterized
    • Single cell-line system
  7. 2024 High

    The identification of SEC23IP as the ERES adaptor for VPS13B/COH1 bridged COPII vesicle budding to lipid transfer-dependent ERGIC tubule formation, and disease mutations in VPS13B-VAB that disrupt this interaction explained a molecular basis for procollagen export defects relevant to Cohen syndrome.

    Evidence Co-immunoprecipitation of direct VPS13B–SEC23IP interaction, knockout cell lines with live imaging of ERGIC tubules, procollagen ER export assay, disease mutation analysis

    PMID:39352497

    Open questions at the time
    • Whether SEC23IP–VPS13B interaction is sufficient for tubule formation or requires additional factors is unknown
    • In vivo confirmation in animal models lacking
  8. 2025 High

    Cell-free reconstitution demonstrated that p125A simultaneously binds PI4P, Sec31, and Sec23 to tether donor (ERES) and acceptor (ERGIC/cis-Golgi) membranes, providing the first mechanistic explanation for how outer COPII coat assembly is coupled to tunnel-based transport of fibrillar collagens.

    Evidence Cell-free membrane reconstitution, COPII coat assembly and PI4P-binding assays, chimeric domain swaps, KO cell transcriptomics and secretome mass spectrometry (preprint)

    PMID:40463098

    Open questions at the time
    • Preprint awaiting peer review
    • Structural basis of simultaneous tripartite binding unresolved
    • Whether PI4P binding is essential in vivo not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include whether SEC23IP possesses intrinsic lipase activity, the atomic structure of the SEC23IP–Sec23–Sec31 ternary complex, and the precise cargo repertoire beyond collagens that depends on SEC23IP-mediated membrane tethering.
  • No crystal or cryo-EM structure available
  • Catalytic competence of the lipase homology domain untested for p125 itself
  • Full spectrum of SEC23IP-dependent cargoes undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0008289 lipid binding 1
Localization
GO:0005783 endoplasmic reticulum 4 GO:0005829 cytosol 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 5 R-HSA-392499 Metabolism of proteins 2
Partners
SEC13SEC23ASEC31AVPS13B
Complex memberships
COPII outer coat (Sec13/Sec31A/p125A)

Evidence

Reading pass · 9 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 p125 (SEC23IP) was identified as a novel mammalian Sec23p-interacting protein distinct from Sec24p. Using a GST-Sec23p fusion protein pulldown from mammalian cells, p125 was purified and characterized. The N-terminal proline-rich region of p125 mediates binding to Sec23p, confirmed by yeast two-hybrid assay. Overexpression of p125, like mammalian Sec23p, caused disorganization of the ER-Golgi intermediate compartment (ERGIC) and Golgi apparatus, implicating p125 in the early secretory pathway. p125 harbors sequence homology to phospholipid-modifying proteins, particularly phosphatidic acid-preferring phospholipase A1. GST pulldown, yeast two-hybrid, overexpression with organelle morphology readout (immunofluorescence) The Journal of biological chemistry High 10400679
2000 The functional regions of p125 were mapped by deletion analysis: the proline-rich region (residues 135–259) is responsible for binding to Sec23p, while correct subcellular localization requires residues 135–1000 encompassing both the proline-rich and phospholipase A1 homology regions. Expressed p125 co-localizes with the vesicle-tethering proteins p115 and GM130 at ER-Golgi intermediate regions. Deletion mutagenesis, co-localization by immunofluorescence, co-localization with Golgi tethering markers Biochemical and biophysical research communications Medium 11112430
2002 A paralog of p125, KIAA0725p, was identified and shown to possess phospholipase A1 activity preferentially for phosphatidic acid, whereas p125 itself lacks the Sec23p-interacting proline-rich N-terminal region in the paralog. In vitro binding showed KIAA0725p does not bind Sec23p. This established that p125 belongs to a phosphatidic acid-preferring phospholipase A1 protein family, and that the lipase homology domain and Sec23p-binding activity are separable functions. In vitro binding assay, in vitro phospholipase A1 enzymatic assay, organelle morphology by immunofluorescence The Journal of biological chemistry Medium 11788596
2004 p125 (SEC23IP) was localized by immunofluorescence and electron microscopy to ER exit sites (ERES), the sites where COPII-coated vesicles bud. The p125-specific N-terminal region is critical for ERES localization (chimeric protein analysis). RNAi-mediated depletion of p125 disturbed the organization of ERES and substantially disrupted cis-Golgi structure, without significantly delaying protein export from the ER, suggesting p125 is a mammalian-specific organizer of ERES architecture. Immunofluorescence microscopy, electron microscopy, chimeric protein domain-swap analysis, RNAi knockdown with organelle morphology readout The Journal of biological chemistry High 15623529
2010 p125A (SEC23IP) was shown to interact not only with Sec23A but also with the C-terminal region of Sec31A, via a distinct domain (residues 260–600). Gel filtration and immunodepletion studies demonstrated that the majority of cytosolic p125A exists as a ternary complex with Sec13/Sec31A, forming preassembled Sec13/Sec31A/p125A heterohexamers. Silencing p125A affected Golgi morphology and impaired protein export from the ER, placing p125A as a component of the Sec13/Sec31A outer COPII subcomplex. Co-immunoprecipitation, gel filtration, immunodepletion, RNAi knockdown with ER export and Golgi morphology readouts The Journal of cell biology High 20679433
2011 p125/Sec23ip knockout mice are viable and grow normally but males are subfertile. Sperm from knockout mice have round heads and lack the acrosome, the enzyme-containing organelle essential for fertilization. p125 is expressed during stages I–XII of spermatogenesis, coinciding with acrosome biogenesis. This established an essential in vivo role for Sec23ip in spermiogenesis, specifically acrosome formation. Gene knockout mouse model, histological and morphological analysis of sperm, immunostaining for stage-specific expression FEBS letters High 21640725
2020 Sec23ip was identified as part of the 14-3-3γ protein interaction network in MA-10 Leydig cells by LC-MS proteomics. siRNA-mediated silencing of Sec23ip decreased steroidogenesis, and cholesterol mobilization from the cytoplasmic membrane to mitochondria was impaired in Sec23ip-silenced cells, suggesting Sec23ip contributes to cholesterol trafficking required for acute steroid hormone production. LC-MS proteomics (co-IP with 14-3-3γ), siRNA knockdown with steroidogenesis assay and cholesterol trafficking readout Endocrinology Medium 31875919
2024 Sec23IP at ER exit sites (ERES) was identified as a VPS13B/COH1 adaptor. VPS13B interacts directly with Sec23IP via its VPS13 adaptor binding domain (VAB). Disease-associated missense mutations in VPS13B-VAB impair interaction with Sec23IP. Knockout of VPS13B or Sec23IP blocks formation of tubular ERGIC (a cargo carrier for ER-to-Golgi transport) and delays ER export of procollagen, linking Sec23IP to procollagen secretion and potentially to joint laxity in Cohen syndrome patients. Co-immunoprecipitation (direct interaction), knockout cell lines, live imaging of ERGIC tubule formation, procollagen ER export assay, disease mutation analysis The Journal of cell biology High 39352497
2025 Using cell-free reconstitutions, p125A (Sec23ip) was shown to bind phosphatidylinositol 4-phosphate (PI4P), Sec31, and Sec23 simultaneously, stabilizing contact between ER exit site (donor) membranes and ERGIC/cis-Golgi (acceptor) membranes. This membrane apposition promoted COPII outer layer (Sec13/31) assembly. In cells lacking p125A, outer COPII coat assembly was selectively destabilized. Transcriptome and secretome analyses revealed selective impairment of fibrillar collagen secretion in p125A-deficient cells, with p125A specifically coupling COPII outer coat assembly to tunnel-based collagen traffic. Cell-free membrane reconstitution, COPII coat assembly assay, PI4P-binding assay, p125A-chimera domain swap, ERES imaging in KO cells, transcriptomics and secretome mass spectrometry bioRxivpreprint High 40463098

Source papers

Stage 0 corpus · 88 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 1718 22658674
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2015 Gene essentiality and synthetic lethality in haploid human cells. Science (New York, N.Y.) 657 26472760
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2018 High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Molecular cell 580 29395067
2021 Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature 532 33845483
2014 Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature 445 25231870
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2015 A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 433 26638075
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2017 Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions. Nature biotechnology 378 28319085
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2012 A high-throughput approach for measuring temporal changes in the interactome. Nature methods 273 22863883
1993 Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton. The Journal of biological chemistry 270 8314789
2010 Systematic discovery of nonobvious human disease models through orthologous phenotypes. Proceedings of the National Academy of Sciences of the United States of America 223 20308572
1997 NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn). The Journal of biological chemistry 218 9079653
2016 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nature communications 211 27173435
2018 An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Nature communications 201 29568061
2015 A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. eLife 198 26673895
2014 Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes. Molecular cell 173 25544563
2009 Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Gut 157 19240061
2020 AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System. Molecular cell 152 31995728
1999 Pulsatile stretch activates mitogen-activated protein kinase (MAPK) family members and focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes. Biochemical and biophysical research communications 126 10334907
1995 Differential effects of platelet-derived growth factor BB on p125 focal adhesion kinase and paxillin tyrosine phosphorylation and on cell migration in rabbit aortic vascular smooth muscle cells and Swiss 3T3 fibroblasts. The Journal of biological chemistry 110 7538114
1996 Bombesin, bradykinin, vasopressin, and phorbol esters rapidly and transiently activate Src family tyrosine kinases in Swiss 3T3 cells. Dissociation from tyrosine phosphorylation of p125 focal adhesion kinase. The Journal of biological chemistry 109 8910389
1996 Requirement for phosphatidylinositol 3'-kinase activity in platelet-derived growth factor-stimulated tyrosine phosphorylation of p125 focal adhesion kinase and paxillin. The Journal of biological chemistry 93 8631827
1999 p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins. The Journal of biological chemistry 90 10400679
1999 The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription. Molecular and cellular biology 88 10373543
2002 A novel phospholipase A1 with sequence homology to a mammalian Sec23p-interacting protein, p125. The Journal of biological chemistry 86 11788596
1998 Activation of human endothelial cells via S-endo-1 antigen (CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125(FAK). The Journal of biological chemistry 86 9756930
2000 p125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo. Journal of cell science 84 11069767
2011 Coronavirus infection induces DNA replication stress partly through interaction of its nonstructural protein 13 with the p125 subunit of DNA polymerase δ. The Journal of biological chemistry 81 21918226
2004 p125 is localized in endoplasmic reticulum exit sites and involved in their organization. The Journal of biological chemistry 80 15623529
1999 Direct interaction of proliferating cell nuclear antigen with the p125 catalytic subunit of mammalian DNA polymerase delta. The Journal of biological chemistry 75 10480866
1998 Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription. The Journal of biological chemistry 69 9553131
1996 Dissociation of mitogen-activated protein kinase activation from p125 focal adhesion kinase tyrosine phosphorylation in Swiss 3T3 cells stimulated by bombesin, lysophosphatidic acid, and platelet-derived growth factor. Molecular biology of the cell 60 8970151
1993 RNA insertions and gene duplications in the nonstructural protein p125 region of pestivirus strains and isolates in vitro and in vivo. Virology 54 8384762
2010 p125A exists as part of the mammalian Sec13/Sec31 COPII subcomplex to facilitate ER-Golgi transport. The Journal of cell biology 48 20679433
1992 Heterogeneous expression of the non-structural protein p80/p125 in cells infected with different pestiviruses. The Journal of general virology 47 1309861
2002 Low Mr phosphotyrosine protein phosphatase associates and dephosphorylates p125 focal adhesion kinase, interfering with cell motility and spreading. The Journal of biological chemistry 43 12055185
2000 Integrin-independent tyrosine phosphorylation of p125(fak) in human platelets stimulated by collagen. The Journal of biological chemistry 36 11110790
1999 Hypoxia induces activation and subcellular translocation of focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes. Biochemical and biophysical research communications 35 10448107
2006 Basic fibroblast growth factor promotes melanocyte migration via increased expression of p125(FAK) on melanocytes. Acta dermato-venereologica 34 17106595
1998 Are tyrosine phosphorylation of p125(FAK) and paxillin or the small GTP binding protein, rho, needed for CCK-stimulated pancreatic amylase secretion? Biochimica et biophysica acta 31 9739170
2001 Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells. Journal of cellular physiology 29 11382927
2000 Determination of functional regions of p125, a novel mammalian Sec23p-interacting protein. Biochemical and biophysical research communications 29 11112430
1995 Comparison of the p125 coding region of bovine viral diarrhea viruses. Veterinary microbiology 26 7653028
2004 Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with the p125 subunit of DNA polymerase delta or DNA ligase I. Experimental cell research 23 14729473
1996 Glucose-induced tyrosine phosphorylation of p125 in beta cells and pancreatic islets. A novel proximal signal in insulin secretion. The Journal of biological chemistry 23 8798659
2011 p125/Sec23-interacting protein (Sec23ip) is required for spermiogenesis. FEBS letters 22 21640725
1998 Characterization of the p125 subunit of human DNA polymerase delta and its deletion mutants. Interaction with cyclin-dependent kinase-cyclins. The Journal of biological chemistry 22 9545286
1998 Pervanadate stimulates amylase release and protein tyrosine phosphorylation of paxillin and p125(FAK) in differentiated AR4-2J pancreatic acinar cells. The Journal of biological chemistry 21 9632700
2016 p53 inhibits the expression of p125 and the methylation of POLD1 gene promoter by downregulating the Sp1-induced DNMT1 activities in breast cancer. OncoTargets and therapy 20 27022290
2011 Significance of DNA polymerase delta catalytic subunit p125 induced by mutant p53 in the invasive potential of human hepatocellular carcinoma. Oncology 19 21372597
1993 Identification of p125, a component of a group of 120-kDa proteins that are phosphorylated on tyrosine residues in response to bradykinin and bombesin stimulation, in anti-ras-GTPase-activating protein immunoprecipitates of Swiss 3T3 cells. The Journal of biological chemistry 19 7681835
2021 Inhibition of Vasculogenic Mimicry and Angiogenesis by an Anti-EGFR IgG1-Human Endostatin-P125A Fusion Protein Reduces Triple Negative Breast Cancer Metastases. Cells 18 34831127
1995 Endothelin-1 stimulates tyrosine phosphorylation of p125 focal adhesion kinase in mesangial cells. Journal of the American Society of Nephrology : JASN 18 8589330
1999 Low density lipoprotein phosphorylates the focal adhesion-associated kinase p125(FAK) in human platelets independent of integrin alphaIIb beta3. The Journal of biological chemistry 17 9867854
1997 Decrease in the amount of focal adhesion kinase (p125(FAK)) in interleukin-1beta-stimulated human umbilical vein endothelial cells by binding of human monocytic cell lines. The Journal of biological chemistry 15 9252385
2024 Sec23IP recruits VPS13B/COH1 to ER exit site-Golgi interface for tubular ERGIC formation. The Journal of cell biology 13 39352497
2000 Tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin does not require extracellular signal-regulated kinase activation in Swiss 3T3 cells stimulated by bombesin or platelet-derived growth factor. Journal of cellular physiology 13 10737896
2000 Nitric oxide stimulates tyrosine phosphorylation of p125(FAK) and paxillin in rat pancreatic acini. Biochemical and biophysical research communications 13 10924330
2010 AAV-P125A-endostatin and paclitaxel treatment increases endoreduplication in endothelial cells and inhibits metastasis of breast cancer. Gene therapy 12 20844568
1999 Regulation of the actin cytoskeleton by p125 focal adhesion kinase in rat pancreatic acinar cells. Digestion 12 10095157
1999 Growth hormone stimulates tyrosine phosphorylation of focal adhesion kinase (p125(FAK)) and actin stress fiber formation in human osteoblast-like cells, Saos2. Biochemical and biophysical research communications 12 10486260
1999 Adhesion to fibronectin promotes the activation of the p125(FAK)/Zap-70complex in human T cells. Immunology 12 10594689
2011 Inhibition of ovarian cancer by RGD-P125A-endostatin-Fc fusion proteins. International journal of cancer 11 21225621
2000 A role for phosphoinositides in tyrosine phosphorylation of p125 focal adhesion kinase in rat pancreatic acini. Cellular signalling 10 10704824
1991 Bovine viral diarrhea virus proteins: relatedness of p175 with p80 and p125 and evidence of glycoprotein processing. Canadian journal of microbiology 9 1663821
2022 RNA-sequencing of myxoinflammatory fibroblastic sarcomas reveals a novel SND1::BRAF fusion and 3 different molecular aberrations with the potential to upregulate the TEAD1 gene including SEC23IP::VGLL3 and TEAD1::MRTFB gene fusions. Virchows Archiv : an international journal of pathology 8 35776191
2000 Expression of focal adhesion kinase (p125 FAK) and proline-rich tyrosine kinase 2 (PYK2/CAKb) in cerebral metastases, correlation with VEGF-R-, ecNOS III-labelling and morphometric data. Anticancer research 8 10928051
2000 Interaction of the retinoblastoma protein (pRb) with the catalytic subunit of DNA polymerase delta (p125). Oncogene 8 11114723
1999 Platelet-activating factor stimulation of p125(FAK) and p130(Cas) tyrosine phosphorylation in brain. Brain research 8 10415383
2020 Identification of Sec23ip, Part of 14-3-3γ Protein Network, as a Regulator of Acute Steroidogenesis in MA-10 Leydig Cells. Endocrinology 7 31875919
1989 An immunocytochemical study of the proliferating cell nuclear matrix antigen p125/6.5 during rat spermatogenesis. Journal of cell science 5 2515195
2024 Antibody-Drug Conjugate αEGFR-E-P125A Reduces Triple-negative Breast Cancer Vasculogenic Mimicry, Motility, and Metastasis through Inhibition of EGFR, Integrin, and FAK/STAT3 Signaling. Cancer research communications 4 38315147
1996 Tyrosine phosphorylation and subcellular redistribution of p125 ras guanosine triphosphatase-activating protein in human neutrophils stimulated with FMLP. FEBS letters 4 8925892
2025 p125A (Sec23ip) couples COPII coat assembly with donor-acceptor membrane organization to facilitate tunnel-based traffic. bioRxiv : the preprint server for biology 3 40463098