Affinage

S1PR2

Sphingosine 1-phosphate receptor 2 · UniProt O95136

Length
353 aa
Mass
38.9 kDa
Annotated
2026-06-10
100 papers in source corpus 43 papers cited in narrative 43 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

S1PR2 is a sphingosine-1-phosphate (S1P) receptor of the G protein-coupled family that couples S1P sensing to cytoskeletal, growth-control, and barrier-regulatory outputs across diverse tissues (PMID:9854026, PMID:11094076). It binds S1P and sphinganine-1-phosphate with high affinity and engages Gi, Gq, and G13 heterotrimeric G proteins, mobilizing Ca2+, activating MAPK/JNK/p38 cascades, and driving Rho-dependent stress-fiber formation (PMID:10488065, PMID:9854026, PMID:9988698). A defining feature distinguishing S1PR2 from related receptors is its predominant signaling through Gα13 to RhoA, where it stimulates Rac-GAP activity to inhibit Rac and suppress cell migration and chemotaxis (PMID:11094076); cryo-EM of the S1P-bound S1PR2–G13 complex shows that ICL2 engages the Gα13 α5 helix with ICL2 conformation constrained by TM4 (PMID:35353559). Through this Gα13/RhoA/ROCK axis S1PR2 phosphorylates ERM proteins to form filopodia, activates NF-κB via PKC and Ca2+, and couples S1P to phospholipase D (PMID:11673450, PMID:14499732, PMID:23106337). S1PR2 also serves as a receptor for the Nogo-A-Δ20 domain at a site distinct from the S1P pocket, signaling via G13/LARG/RhoA to repress neurite outgrowth and synaptic plasticity, consistent with its requirement for restraining neuronal excitability in vivo (PMID:11553273, PMID:24453941). In immunity and cancer it acts as a tumor suppressor in germinal-center B cells, confining cells and dampening Akt; it is a direct transcriptional target of the TGF-β/TGFBR2/SMAD1 axis, and its loss accelerates MYC-driven lymphomagenesis, with G13 overexpression phenocopying its proapoptotic effect (PMID:22500830, PMID:26729899, PMID:29615404). Across epithelial and stellate-cell contexts S1PR2 activates YAP, including MST1/2-independent YAP activation driving hepatocellular proliferation and AT2-to-AT1 differentiation in alveolar repair (PMID:29903770, PMID:32610129), and in osteoblasts it triggers RhoA/ROCK-dependent Smad1/5/8 phosphorylation and Runx2 induction (PMID:27612439). In endothelium it controls vascular permeability and inflammation through Rho-kinase/NF-κB, p38, and RhoA/ROCK1/DRP1-driven mitochondrial fission and NLRP3-dependent pyroptosis (PMID:23723450, PMID:38909407). Loss-of-function mutations in S1PR2 cause autosomal-recessive profound hearing loss (DFNB68) through stria vascularis degeneration and reduced endocochlear potential (PMID:26805784, PMID:27383011).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1999 High

    Establishing which ligand S1PR2 senses and which G proteins it engages was the foundational step defining it as an S1P receptor with broader G protein coupling than EDG1.

    Evidence Radioligand binding, subunit-selective [35S]GTPgammaS assays, and Ca2+/kinase/cytoskeletal readouts in Sf9, HEK293, CHO, and Xenopus systems

    PMID:10383399 PMID:10488065 PMID:9854026 PMID:9988698

    Open questions at the time
    • Endogenous physiological context of multi-G-protein coupling not addressed in heterologous systems
    • Quantitative bias among Gi/Gq/G13 not resolved
  2. 2000 High

    Identifying that S1PR2 uniquely inhibits Rac and migration distinguished its signaling logic from migration-promoting S1P receptors and defined its anti-migratory function.

    Evidence Rac/RhoA pull-downs, Rac-GAP/GEF and PI3K assays, and chemotaxis in CHO cells expressing distinct EDG receptors; NF-κB reporter dissection

    PMID:11094076 PMID:11673450

    Open questions at the time
    • Identity of the Rac-GAP activated by S1PR2 not defined
    • Direct link between G protein subtype and Rac-GAP not established
  3. 2001 High

    Knockout confirmed an in vivo role: S1PR2 is required to restrain neuronal excitability, moving its function from cell-culture phenotypes to organismal physiology.

    Evidence S1pr2-/- mice with EEG and whole-cell patch-clamp of neocortical pyramidal neurons

    PMID:11553273

    Open questions at the time
    • Molecular mechanism linking S1PR2 to excitability not resolved
    • Cell type mediating the seizure phenotype not pinpointed
  4. 2003 High

    Linking S1PR2 to Rho-dependent growth inhibition and PLD coupling defined effector pathways downstream of the receptor in hepatocytes and myoblasts.

    Evidence C3 exotoxin, JTE-013 antagonist, and pertussis toxin in hepatocyte DNA-synthesis assays; receptor-subtype gain/loss-of-function PLD assays in C2C12 cells

    PMID:12557151 PMID:14499732

    Open questions at the time
    • Mechanism coupling S1PR2 to PLD not molecularly defined
    • Gi-independence of Rho activation not structurally explained
  5. 2013 High

    Discovery that S1PR2 binds Nogo-A-Δ20 at a non-S1P site established it as a dual-ligand receptor mediating myelin-associated inhibition of neurite outgrowth and synaptic plasticity.

    Evidence Binding assays, siRNA, knockout, and hippocampal LTP recordings across wild-type and Nogo-A-/- mice

    PMID:24453941

    Open questions at the time
    • Structural basis of the distinct Nogo-A binding site not resolved
    • Relative physiological weight of S1P vs Nogo-A ligand inputs unclear
  6. 2013 High

    Defining the G13/RhoGEF/RhoA effector module and its cytoskeletal outputs unified S1PR2 signaling across endothelial barrier, developmental migration, and filopodia formation.

    Evidence S1pr2 KO mice, bone marrow chimeras, zebrafish genetic epistasis with endoderm transplantation, and ERM phosphomimetic mutants

    PMID:23106337 PMID:23318642 PMID:23723450

    Open questions at the time
    • Tissue-specific RhoGEF identities not all defined
    • How a single Rho axis produces opposing barrier-protective vs barrier-damaging outcomes not reconciled
  7. 2016 High

    Demonstrating S1PR2 as a germinal-center tumor suppressor and as a cause of recessive hearing loss linked the receptor to both lymphomagenesis control and cochlear homeostasis.

    Evidence Wild-type vs signaling-deficient S1PR2 expression with G13 phenocopy in DLBCL xenografts; exome sequencing of DFNB68 families plus S1pr2-/- and stonedeaf mouse phenotyping with endocochlear potential measurement

    PMID:26729899 PMID:26805784 PMID:27383011

    Open questions at the time
    • Mechanism by which S1PR2 maintains stria vascularis and endocochlear potential not molecularly defined
    • Effector linking S1PR2/G13 to B-cell apoptosis not fully identified
  8. 2018 High

    Identifying TGF-β/SMAD1 as a direct transcriptional activator of S1PR2 placed the receptor within an upstream regulatory circuit that, when lost, accelerates MYC-driven lymphoma.

    Evidence ChIP of phospho-SMAD1 at the S1PR2 locus, CRISPR epistasis of S1PR2/SMAD1/TGFBR2, and GC B-cell-specific Tgfbr2 knockout mice

    PMID:29615404

    Open questions at the time
    • Downstream apoptotic effectors of the TGF-β–S1PR2 axis incompletely mapped
    • Cross-talk with EBV LMP1-mediated repression of S1PR2 not integrated
  9. 2018 Medium

    Connecting S1PR2 to MST1/2-independent YAP activation defined a growth- and repair-driving branch operating in liver and lung epithelium.

    Evidence siRNA, YAP reporter and CTGF/CYR61 analyses in HCC cells; endothelial-specific Sphk1 knockout linking endothelial S1P to AT2 YAP activation

    PMID:29903770 PMID:32610129

    Open questions at the time
    • Mechanism of MST-independent YAP activation by S1PR2 not defined
    • How the Rho axis feeds into YAP in these contexts not resolved
  10. 2022 High

    The cryo-EM S1PR2–G13 structure provided the physical basis for selective G13 coupling and explained agonist and variant selectivity differences.

    Evidence Cryo-EM structure determination with TGFα-shedding G13 activation, migration assays, and interface mutagenesis including the F274I variant

    PMID:35353559

    Open questions at the time
    • Structures with Gi/Gq or with the Nogo-A ligand not determined
    • Conformational basis for biased signaling not addressed
  11. 2024 High

    Bidirectional endothelial genetic models established S1PR2 as a context-dependent driver of vascular pathology through RhoA/ROCK1-coupled mitochondrial and AKT/eNOS branches.

    Evidence EC-specific S1pr2 loss- and gain-of-function mice in cardiac I/R and hindlimb ischemia models with RhoA/ROCK1/DRP1, NLRP3/pyroptosis, and AKT/eNOS readouts

    PMID:35537530 PMID:35836816 PMID:38909407

    Open questions at the time
    • Determinants selecting protective vs damaging endothelial outputs unknown
    • Relationship between mitochondrial fission and barrier disruption branches not unified

Open questions

Synthesis pass · forward-looking unresolved questions
  • How S1PR2 coordinates its multiple, sometimes opposing outputs (Rac inhibition, YAP activation, NF-κB, Smad phosphorylation) in a cell-type-specific manner remains unresolved.
  • No unifying model for context-dependent effector selection
  • Determinants of ligand choice (S1P vs Nogo-A vs bile acids) in vivo unclear
  • Structural basis of non-G13 coupling not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 5 GO:0008289 lipid binding 2 GO:0048018 receptor ligand activity 1
Localization
GO:0005886 plasma membrane 2 GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-168256 Immune System 4 R-HSA-5357801 Programmed Cell Death 4 R-HSA-1266738 Developmental Biology 3 R-HSA-1643685 Disease 3
Partners
GNA13LARGMYDGFNOGO-ARHOA

Evidence

Reading pass · 43 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 H218/EDG5/S1PR2 couples to Gi, Gq, and G13 families of heterotrimeric G proteins, in contrast to EDG1 which couples only to Gi. This was demonstrated using a subunit-selective [35S]GTPgammaS binding assay in Sf9 and HEK293 cells. Subunit-selective [35S]GTPgammaS binding assay in Sf9 and HEK293 cells The Journal of biological chemistry High 10488065
1999 AGR16/S1PR2 expressed in CHO cells binds [32P]S1P specifically (displaced by S1P and sphingosylphosphorylcholine but not LPA), mobilizes intracellular Ca2+ via both PTX-sensitive and PTX-insensitive pathways, activates MAPK in a PTX-sensitive Ras-dependent manner, activates stress-activated kinases (JNK and p38) in a PTX-insensitive manner, induces stress-fiber formation via Rho (PTX-insensitive), and increases cellular cAMP. Radioligand binding, Ca2+ mobilization assay, MAPK/JNK/p38 kinase assays, myosin light chain phosphorylation, cAMP measurement in CHO cells stably expressing AGR16 The Biochemical journal High 9854026
1999 EDG5/S1PR2 expressed in Xenopus oocytes confers S1P-responsive intracellular calcium transients that are potentiated by co-injection of Galphaqi or Galphaq, indicating differential coupling to Gq versus Gi pathways compared to EDG1. Xenopus oocyte expression system, mRNA microinjection, calcium transient recordings, chimeric G protein co-expression The Journal of biological chemistry High 10383399
1999 H218/S1PR2 binds S1P and sphinganine 1-phosphate with high affinity and specificity; overexpression in HEK293 cells induces rounded cell morphology and apoptosis in the presence of serum (which contains high S1P), and overexpression in PC12 cells inhibits NGF-induced neuritogenesis and enhances SPP-induced neurite retraction. Radioligand competition binding, cell morphology assay, apoptosis measurement, PC12 NGF differentiation assay, neurite retraction assay The Journal of biological chemistry High 9988698
2000 EDG5/S1PR2 specifically inhibits Rac activity and cell migration/membrane ruffling in CHO cells, in contrast to EDG1 and EDG3 which stimulate these responses. S1P via EDG5 stimulates Rac-GAP activity (rather than inhibiting Rac-GEF), inhibits basal Rac-GTP levels, and abolishes IGF-I-directed chemotaxis. EDG5 still activates PI3-kinase but uncouples it from Rac activation. Chemotaxis assay, Rac/RhoA pull-down (GTP-bound form), PI3-kinase assay, Rac-GAP/GEF activity assays in CHO cells stably expressing EDG1, EDG3, or EDG5 Molecular and cellular biology High 11094076
2000 EDG3/S1PR3 and EDG5/S1PR2 (but not EDG1) mediate S1P-induced activation of NF-κB in HEK293 cells; this activation requires protein kinase C and Ca2+ downstream of Gq, but not Rho activation alone. Gβγ potentiates NF-κB activation achieved through other G proteins. NF-κB reporter assay, pharmacological inhibitors of PKC and Ca2+, dominant-negative Rho, Gβγ titration in HEK293 cells overexpressing Edg receptor subtypes The Journal of biological chemistry Medium 11673450
2001 Knockout of H218/S1PR2 in mice does not cause developmental defects but leads to spontaneous seizures at 3-7 weeks of age; whole-cell patch-clamp recordings show a large increase in excitability of neocortical pyramidal neurons in H218-/- mice, establishing S1PR2 as a required modulator of neuronal excitability in vivo. Gene knockout mice, EEG recordings, whole-cell patch-clamp electrophysiology of neocortical pyramidal neurons The European journal of neuroscience High 11553273
2003 EDG5/S1PR2 mediates S1P-induced antiproliferative effects in rat hepatocytes via activation of Rho. The inhibitory effect on HGF/EGF-induced DNA synthesis is blocked by C3 exotoxin (Rho inactivation) and by the S1PR2-specific antagonist JTE-013, but not by pertussis toxin, indicating Gi-independent Rho signaling through S1PR2. DNA synthesis assay ([3H]thymidine incorporation), C3 exotoxin Rho inactivation, pertussis toxin treatment, JTE-013 antagonist, partial hepatectomy model in rats Gastroenterology High 12557151
2003 Down-regulation of EDG5/S1PR2 during C2C12 myoblast-to-myotube differentiation specifically uncouples S1P signaling to phospholipase D (PLD). Overexpression of EDG5/S1PR2 (but not EDG1 or EDG3) potentiates S1P-stimulated PLD activity, and antisense knockdown of EDG5/S1PR2 reduces S1P-induced PLD activity, establishing S1PR2 as the dominant receptor coupling S1P to PLD. Northern blot, Western blot, PLD activity assay, overexpression of receptor subtypes, antisense ODN knockdown in C2C12 cells Biochimica et biophysica acta High 14499732
2013 S1PR2 plays a key role in endothelial vascular permeability and inflammatory responses during endotoxemia. Downstream signaling includes activation of the stress-activated protein kinase pathway together with Rho-kinase/NF-κB pathway, both required for S1PR2-mediated endothelial inflammatory responses. Bone marrow chimera experiments localize the critical function to the stromal compartment. S1pr2 knockout mice, bone marrow chimeras, JTE013 pharmacological antagonist, in vitro TNFα endothelial inflammation assays, permeability assays, NF-κB pathway analysis Blood High 23723450
2013 S1PR2 is a receptor for the Nogo-A-Δ20 domain of Nogo-A, distinct from the S1P binding pocket. Nogo-A-Δ20 binding to S1PR2 signals via G13, the Rho GEF LARG, and RhoA. S1PR2 deletion or blockade counteracts Nogo-A-Δ20-mediated and myelin-mediated inhibition of neurite outgrowth and cell spreading. S1PR2 blockade strongly enhances LTP in wild-type but not Nogo-A-/- hippocampus, establishing the Nogo-A/S1PR2 axis as a repressor of synaptic plasticity. Binding assays, siRNA knockdown, S1PR2 knockout, LTP recording in hippocampal slices, neurite outgrowth assays, cell spreading assays, pharmacological blockade with S1PR2 antagonist PLoS biology High 24453941
2013 In zebrafish, S1pr2/Mil signals through Gα13 and a RhoGEF-dependent pathway to regulate convergent movement of the anterior endoderm, which is required for coordinating myocardial migration to the midline. Cardiac-specific expression of Gα13 fails to rescue cardia bifida caused by global Gα13 inhibition, confirming S1pr2/Gα13 acts in the endoderm, not the myocardium. Zebrafish genetic epistasis (morpholino knockdown, dominant-negative constructs), endoderm transplantation rescue experiments, cardiac-specific Gα13 expression Development (Cambridge, England) High 23318642
2013 S1P via S1PR2 induces filopodia formation through phosphorylation of ERM (ezrin/radixin/moesin) proteins. Phosphomimetic ezrin mutants reproduce the filopodia phenotype, while non-phosphorylatable mutants block it. siRNA and genetic knockout approaches identify S1PR2 as the specific and necessary receptor for ERM phosphorylation and filopodia formation. Pharmacological S1PR agonists/antagonists, siRNA knockdown, genetic knockout, phosphomimetic/non-phosphorylatable ezrin mutants, immunofluorescence for filopodia The Biochemical journal High 23106337
2012 S1PR2 promotes germinal center B-cell confinement and dampens Akt activation; S1PR2 deficiency or deficiency of components of its signaling pathway results in loss of growth control in chronically stimulated mucosal germinal centers. S1PR2 knockout mice, germinal center analysis, Akt activation assays Immunological reviews Medium 22500830
2012 S1PR2 mediates satellite cell activation in dystrophic muscle via STAT3 signaling. S1P via S1PR2 inhibits Rac1, which activates STAT3, leading to downregulation of p21 and p27 in myoblasts, thereby promoting cell cycle progression. S1PR2 pharmacological inhibition, siRNA knockdown, Rac1/STAT3 activity assays, p21/p27 expression in mdx mouse model and myoblast cultures PloS one Medium 22606352
2016 S1PR2 acts as a tumor suppressor in DLBCL; ectopic expression of wild-type S1PR2 (but not a signaling-deficient point mutant) induces apoptosis in DLBCL cells and restricts tumor growth in subcutaneous and orthotopic models. The proapoptotic effects are phenocopied by Gα13 overexpression and are independent of AKT signaling. Ectopic expression of wild-type vs. signaling-deficient S1PR2 mutant, Gα13 overexpression, subcutaneous and orthotopic xenograft mouse models, apoptosis assays Blood High 26729899
2018 The TGF-β/TGF-βR2/SMAD1 axis directly activates S1PR2 transcription; phosphorylated SMAD1 binds regulatory elements in the S1PR2 locus (by ChIP). CRISPR-mediated editing of S1PR2, SMAD1, or TGFBR2 renders DLBCL cells unresponsive to TGF-β-induced apoptosis. Loss of S1pr2 or Tgfbr2 in GC B cells induces hyperproliferation and accelerates MYC-driven lymphomagenesis. ChIP of phospho-SMAD1 at S1PR2 locus, CRISPR editing of S1PR2/SMAD1/TGFBR2, xenotransplantation models, GC B cell-specific Tgfbr2 knockout mice Blood High 29615404
2016 S1P/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation via a Gi-independent RhoA/ROCK pathway in osteoblasts, leading to nuclear translocation of Smad4 and upregulation of Runx2 expression, promoting osteoblast differentiation. Pharmacological inhibitors (JTE-013, ROCK inhibitors), RhoA activity assay, Smad1/5/8 phosphorylation by Western blot, nuclear translocation imaging, in vivo bone formation assay in MC3T3-E1 cells and primary osteoblasts Bone Medium 27612439
2018 S1PR2 mediates S1P-induced YAP activation in hepatocellular carcinoma cells (both human and mouse) in an MST1/2-independent manner, leading to YAP-mediated CTGF upregulation and cell proliferation. siRNA knockdown shows only CTGF (not CYR61) is required for S1P-stimulated proliferation. siRNA knockdown of S1PR2 and pathway components, YAP reporter assays, CTGF/CYR61 expression, proliferation assays, ChIP-seq for HNF4α, YAP transgenic mouse hepatocytes Molecular cancer research : MCR Medium 29903770
2020 Endothelial-derived S1P acts via S1PR2 on alveolar type II (AT2) cells to induce nuclear translocation of YAP, promoting AT2-to-AT1 differentiation required for alveolar repair after lung injury. This was established using endothelial-specific Sphk1 knockout mice. Endothelial-specific Sphk1 knockout mice, immunofluorescence for YAP nuclear translocation, AT1/AT2 cell quantification after Pseudomonas lung injury Cell reports Medium 32610129
2022 Cryo-EM structure of S1P-bound S1PR2 coupled to heterotrimeric G13 reveals that ICL2 of S1PR2 interacts with the α5 helix of Gα13, with ICL2 conformation constrained by TM4. FTY720-P (an agonist of S1PR1/3/4/5) can also trigger G13 activation via S1PR2. The S1PR2-F274I variant increases G13 activity with both FTY720-P and S1P, explaining drug selectivity differences. Cryo-electron microscopy structure determination, TGFα shedding assay for G13 activation, cell migration assays, mutagenesis of interface residues Science advances High 35353559
2016 Missense variants p.Arg108Pro and p.Tyr140Cys in S1PR2 cause autosomal-recessive profound hearing loss (DFNB68). Molecular modeling predicts p.Arg108Pro disrupts S1P binding and p.Tyr140Cys disrupts G protein docking. S1pr2-/- mice show stria vascularis abnormalities, organ of Corti degeneration, and profound hearing loss. Exome sequencing, Sanger segregation analysis, S1pr2 knockout mouse phenotyping (auditory physiology, histology), molecular modeling American journal of human genetics High 26805784
2016 A spontaneous Thr289Arg S1pr2 mutation (stonedeaf mouse) causes progressive hearing loss with normal hearing at 2 weeks but severe/profound loss by 14 weeks, associated with a reduced endocochlear potential and stria vascularis degeneration—the first demonstration that S1PR2 loss reduces EP. Mouse ENU mutagenesis screen, exome sequencing, auditory brainstem responses, endocochlear potential measurement, stria vascularis histology Scientific reports High 27383011
2018 S1P-S1PR2 axis mediates homing of MUSE stem cells to infarcted myocardium; this was confirmed pharmacologically (S1PR2-specific antagonist JTE-013 co-injection) and genetically (S1PR2-siRNA introduction into Muse cells) blocking migration/homing to the heart. In vivo cell tracking with Nano-lantern labeling, pharmacological antagonism with JTE-013, S1PR2-siRNA knockdown in Muse cells, rabbit acute MI model Circulation research Medium 29475983
2019 Endothelial S1PR2 regulates lymphatic endothelial cell layer structure and permeability through the ERK pathway, modulating expression of junction molecules VE-cadherin, occludin, and zonulin-1, and facilitates T cell transcellular migration through VCAM-1 expression. S1PR2-knockout LEC studies, ERK pathway inhibitors, junction molecule expression by Western blot/imaging, T cell transmigration assays across LEC monolayers Science immunology Medium 30877143
2020 S1PR2 internalization from plasma membrane to endoplasmic reticulum upon S1P stimulation activates PERK-eIF2α-ATF4 signaling via elevated [Ca2+]ER, leading to RNASET2-mediated intracellular uracil generation that blunts 5-FU efficacy in colorectal cancer cells. Subcellular fractionation/imaging of S1PR2, [Ca2+]ER measurement with Mag-Fluo-AM, LC-ESI-MS/MS for uracil measurement, JTE-013 pharmacological inhibition, S1PR2-/- villin-S1PR2 knockout mice Acta pharmacologica Sinica Medium 32647340
2022 S1PR2/RhoA/ROCK1 signaling pathway damages intestinal vascular endothelial barrier and promotes M1 macrophage polarization in IBD; inhibition of S1PR2 reduces RhoA/ROCK1 expression, reverses impaired barrier function and M1 polarization, and reduces ER stress in endothelial cells and glycolysis in macrophages. S1PR2 knockdown and pharmacological inhibition (JTE-013), RhoA/ROCK1 expression analysis, barrier permeability assays, macrophage polarization assays, DSS colitis mouse model Biochemical pharmacology Medium 35537530
2024 Endothelial S1PR2 promotes mitochondrial fission and ROS production via RhoA/ROCK1/DRP1 signaling, leading to NLRP3 inflammasome activation and pyroptosis, thereby worsening cardiac ischemia-reperfusion injury. EC-specific S1pr2 loss-of-function reduces injury while gain-of-function aggravates it. EC-specific S1pr2 KO and gain-of-function mice, RhoA/ROCK1/DRP1 protein expression, mitochondrial morphology analysis, NLRP3/pyroptosis markers, cardiac I/R mouse model Redox biology High 38909407
2022 Endothelial S1pr2 inhibits post-ischemic angiogenesis by suppressing the AKT/eNOS signaling pathway, thereby inhibiting EC proliferation, migration, and angiogenic activity. EC-specific S1pr2 loss-of-function enhances angiogenesis and blood flow recovery, while gain-of-function impairs it. EC-specific S1pr2 loss-of-function and gain-of-function mice, hindlimb ischemia model, AKT/eNOS phosphorylation by Western blot, EC proliferation/migration assays, JTE013 pharmacological inhibition Theranostics High 35836816
2023 Taurocholic acid activates S1PR2 in hepatic stellate cells, triggering p38 MAPK/YAP signaling to promote HSC proliferation, migration, contraction, and ECM secretion (fibrosis). Pharmacological or genetic S1PR2 inhibition reverses TCA-induced HSC activation and attenuates cholestatic liver fibrosis in DDC diet mice. JTE-013 pharmacological inhibition, S1PR2 shRNA, LX-2 and JS-1 HSC cell lines, DDC-diet mouse model, p38 MAPK and YAP phosphorylation/activity assays Clinical and molecular hepatology Medium 36800698
2022 GDCA/taurine-conjugated bile acid activates S1PR2 in macrophages to upregulate ZBP1 expression, which is required for ZBP1/p-MLKL-mediated necroptosis in macrophages; selective macrophage S1pr2 knockdown in vivo decreases necroptosis and attenuates collagen deposition in BDL cholestatic liver injury. Macrophage-specific S1pr2 knockdown in vivo, GDCA treatment of BMDMs, ZBP1/p-MLKL Western blot, BDL mouse model, siRNA rescue experiments Cell death & disease Medium 36859525
2016 EBV oncoprotein LMP1 transcriptionally downregulates S1PR2 in GC B cells, and this downregulation drives constitutive activation of the PI3-kinase pathway in ABC-DLBCL cells. LMP1 expression in GC B cells, transcriptional profiling, PI3K pathway activation assays, IHC for S1PR2 in primary LMP1-positive vs. negative DLBCLs The Journal of pathology Medium 30666658
2023 MYDGF directly binds S1PR2 (confirmed by SPR assay and Co-IP), and signals via S1PR2/RhoA/G-actin/F-actin/MRTF-A to suppress VSMC dedifferentiation and neointimal formation in response to balloon injury. Molecular docking, SPR assay, Co-immunoprecipitation, JTE-013 antagonist, CCG-1423 and Ripasudil inhibitors, carotid balloon injury rat model, RhoA activity and actin cytoskeleton assays Acta pharmacologica Sinica Medium 37726422
2011 Mast cells react to vaccinia virus and degranulate via a membrane-activated pathway triggered by S1PR2; neutralizing antibody to the VV L1 fusion entry protein inhibits degranulation by preventing S1PR2 activation by viral membrane lipids. Antimicrobial peptide release from MC granules is necessary to inactivate VV infectivity. MC-deficient mouse model, MC reconstitution experiments, cathelicidin-KO MC studies, S1PR2 pathway analysis, neutralizing antibody experiments, skin infection model Journal of immunology Medium 22140255
2022 Liver sinusoidal endothelial cell S1pr2 activates the YAP signaling pathway to potentiate TGF-β transactivation in a paracrine manner acting on hepatic stellate cells, thereby aggravating liver fibrosis. LSEC-specific S1pr2 loss-of-function dampens HSC activation while overexpression enhances it. LSEC-specific S1pr2 KO and overexpression, CCl4 liver fibrosis model, YAP activity assays, TGF-β expression/secretion, HSC activation markers, paracrine co-culture experiments FASEB journal Medium 37039817
2021 Preeclampsia is associated with reduced S1P and SPHK1. S1P increases trophoblast cell invasion via S1PR2-activated RhoA/ROCK-induced actin polymerization that promotes YAP nuclear translocation; in vivo inhibition of sphingosine kinase 1 during placentation causes a preeclampsia phenotype. SPHK1 inhibitor mouse model, HTR8/SVneo cell invasion assays, actin polymerization measurement, YAP nuclear translocation imaging, YAP-5SA mutant, S1PR2 pharmacological inhibition Hypertension Medium 34865521
2022 Overexpression of endothelial S1pr2 after traumatic brain injury promotes BBB disruption by activating JNK/c-Jun signaling, which transactivates MMP-9; ChIP-qPCR confirmed AP-1a and AP-1b binding sites in the MMP-9 promoter as phospho-c-Jun binding sites. TBI mouse model, JTE-013 pharmacological inhibition, SP600125 JNK inhibitor, Western blot for JNK/c-Jun/MMP-9, tight junction protein analysis, ChIP-qPCR for c-Jun binding to MMP-9 promoter, cellular models Frontiers in pharmacology Medium 39679379
2022 Enhanced S1PR2 membrane expression in the cerebellum of hyperammonaemic rats increases CCL2 (especially in Purkinje neurons), activating CCR2 in microglia and increasing P2X4 and BDNF in microglia. BDNF then enhances TrkB activation in neurons, increasing KCC2 membrane expression and GABAergic neurotransmission, leading to motor incoordination. Blocking S1PR2 with JTE-013 normalizes this entire pathway and restores motor coordination. Intracerebral JTE-013 administration via osmotic mini-pumps in hyperammonaemic rats, immunochemistry, immunofluorescence, Western blot for pathway components, beam walking behavioral test Neuropathology and applied neurobiology Medium 35152448
2016 FXR transcriptionally represses S1PR2 expression in hepatic stellate cells; DHA induces FXR expression and reduces S1PR2, thereby inhibiting HSC contraction through modulation of both Ca2+-dependent and Ca2+-sensitization signaling. Gain- and loss-of-function analyses confirm an FXR-S1PR2-dependent mechanism. Gel contraction assays, actin cytoskeleton fluorescence staining, myosin light chain phosphorylation, FXR gain/loss-of-function in LX-2 cells, S1PR2 mRNA/protein expression IUBMB life Medium 27027402
2016 S1PR2 knockdown in DLBCL cells promotes migration and invasion via NF-κB pathway activation; S1PR2 downregulation reduces MMP-9 expression in U266 MM cells. S1PR2-selective antagonist JTE-013, S1PR2 shRNA knockdown in U266 cells, migration/invasion assays, NF-κB pathway analysis, MMP-9 expression by Western blot Cancer management and research Low 32922084
2019 S1P induces IL-8 gene expression through S1PR1 in trophoblast cells, while IL-8 protein secretion is primarily regulated through S1PR2; both Rho-kinase and Rac1 signaling are essential for S1P-induced IL-8 secretion. Selective S1PR antagonists/agonists (JTE-013 for S1PR2, VPC23019 for S1PR1/3, SEW2781 for S1PR1), Rho-kinase inhibitor Y27632, Rac1 inhibitor NSC23766, IL-8 ELISA and real-time PCR in HTR-8/SVneo cells Placenta Medium 26321412
2016 FTY720P inhibits Na+/K+ ATPase in HepG2 cells via S1PR2 through a signaling cascade involving PKC, NF-κB, and PGE2 generation; this effect is blocked by the specific S1PR2 antagonist JTE-013 and mimicked by the S1PR2 agonist CYM5520. Na+/K+ ATPase activity assay, JTE-013, CYM5520 (S1PR2 agonist), PKC inhibitor calphostin, COX-2 inhibitor indomethacin, NF-κB inhibitor in HepG2 cells Biochemistry and cell biology Medium 27501354
2019 Taurine-conjugated bile acid (TCDCA) stimulates cortisol secretion and steroidogenesis-related gene expression in adrenocortical H295R cells via S1PR2 and ERK phosphorylation; siRNA knockdown of S1PR2 reduces ERK phosphorylation and cortisol secretion, while SF-1 transactivation is increased downstream of this pathway. S1PR2 pharmacological inhibition (JTE-013), S1PR2 siRNA knockdown, ERK phosphorylation by Western blot, cortisol ELISA, SF-1 transactivation assay in H295R cells Liver international Medium 30664326

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1999 Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. The Journal of biological chemistry 289 10488065
2000 Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Molecular and cellular biology 275 11094076
1999 Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. The Journal of biological chemistry 226 10383399
2002 Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. Biochemical and biophysical research communications 179 12445827
2000 Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. The Journal of biological chemistry 179 10617617
1999 The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways. The Biochemical journal 173 9854026
1999 Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. The Journal of biological chemistry 165 9988698
2013 Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation. Blood 157 23723450
2001 An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability. The European journal of neuroscience 153 11553273
2014 The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. PLoS biology 144 24453941
1999 EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16. Biochemical and biophysical research communications 142 10381367
2018 S1P-S1PR2 Axis Mediates Homing of Muse Cells Into Damaged Heart for Long-Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction. Circulation research 127 29475983
2012 S1PR2 links germinal center confinement and growth regulation. Immunological reviews 85 22500830
2011 Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides. Journal of immunology (Baltimore, Md. : 1950) 85 22140255
2019 CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration. Science immunology 81 30877143
2003 Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5. Gastroenterology 79 12557151
2018 MicroRNA-149-5p regulates blood-brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 71 29401609
2012 Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway. PloS one 70 22606352
2001 Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells. The Journal of biological chemistry 69 11673450
2018 S1P Stimulates Proliferation by Upregulating CTGF Expression through S1PR2-Mediated YAP Activation. Molecular cancer research : MCR 60 29903770
2022 S1PR2/RhoA/ROCK1 pathway promotes inflammatory bowel disease by inducing intestinal vascular endothelial barrier damage and M1 macrophage polarization. Biochemical pharmacology 56 35537530
2023 Taurocholic acid promotes hepatic stellate cell activation via S1PR2/p38 MAPK/YAP signaling under cholestatic conditions. Clinical and molecular hepatology 55 36800698
2020 Angiocrine Sphingosine-1-Phosphate Activation of S1PR2-YAP Signaling Axis in Alveolar Type II Cells Is Essential for Lung Repair. Cell reports 55 32610129
2013 Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. The Biochemical journal 55 23106337
2016 The hematopoietic oncoprotein FOXP1 promotes tumor cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling. Blood 53 26729899
2018 The tumor suppressive TGF-β/SMAD1/S1PR2 signaling axis is recurrently inactivated in diffuse large B-cell lymphoma. Blood 52 29615404
2022 Structure of S1PR2-heterotrimeric G13 signaling complex. Science advances 49 35353559
2023 Neutrophil CEACAM1 determines susceptibility to NETosis by regulating the S1PR2/S1PR3 axis in liver transplantation. The Journal of clinical investigation 46 36719377
2013 S1pr2/Gα13 signaling controls myocardial migration by regulating endoderm convergence. Development (Cambridge, England) 46 23318642
2024 A detrimental role of endothelial S1PR2 in cardiac ischemia-reperfusion injury via modulating mitochondrial dysfunction, NLRP3 inflammasome activation, and pyroptosis. Redox biology 45 38909407
2019 S1PR2 antagonist ameliorate high glucose-induced fission and dysfunction of mitochondria in HRGECs via regulating ROCK1. BMC nephrology 43 30999892
2018 S1PR2 antagonist alleviates oxidative stress-enhanced brain endothelial permeability by attenuating p38 and Erk1/2-dependent cPLA2 phosphorylation. Cellular signalling 43 30290210
2003 Down-regulation of EDG5/S1P2 during myogenic differentiation results in the specific uncoupling of sphingosine 1-phosphate signalling to phospholipase D. Biochimica et biophysica acta 42 14499732
2000 Differential roles of Edg-1 and Edg-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells. Brain research. Molecular brain research 42 11146117
2018 Inactivation of sphingosine-1-phosphate receptor 2 (S1PR2) decreases demyelination and enhances remyelination in animal models of multiple sclerosis. Neurobiology of disease 41 30468865
2017 Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. Frontiers in bioscience (Landmark edition) 41 27814635
2022 RTN4/Nogo-A-S1PR2 negatively regulates angiogenesis and secondary neural repair through enhancing vascular autophagy in the thalamus after cerebral cortical infarction. Autophagy 39 35263212
2016 Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2. American journal of human genetics 39 26805784
2016 Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. Scientific reports 38 27160553
2002 Sphingosine 1-phosphate evokes calcium signals in C2C12 myoblasts via Edg3 and Edg5 receptors. The Biochemical journal 38 11853542
2022 The S1PR2-CCL2-BDNF-TrkB pathway mediates neuroinflammation and motor incoordination in hyperammonaemia. Neuropathology and applied neurobiology 37 35152448
2017 ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs. Journal of physiology and biochemistry 35 28181168
2016 Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts. Bone 35 27612439
2022 Endothelial S1pr2 regulates post-ischemic angiogenesis via AKT/eNOS signaling pathway. Theranostics 34 35836816
2021 ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway. Cell death discovery 34 33431858
2000 Antisense studies in PC12 cells suggest a role for H218, a sphingosine 1-phosphate receptor, in growth-factor-induced cell-cell interaction and neurite outgrowth. Developmental neuroscience 34 10965150
2021 Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways. Andrology 33 34674380
2023 Necroptosis of macrophage is a key pathological feature in biliary atresia via GDCA/S1PR2/ZBP1/p-MLKL axis. Cell death & disease 32 36859525
2018 Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling. Pathology, research and practice 32 30097213
1997 Embryonic expression pattern of H218, a G-protein coupled receptor homolog, suggests roles in early mammalian nervous system development. Neuroscience 32 9178877
2016 S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse. Scientific reports 30 27383011
2003 Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. Journal of cellular biochemistry 30 12577307
2017 MiR-126 impairs the intestinal barrier function via inhibiting S1PR2 mediated activation of PI3K/AKT signaling pathway. Biochemical and biophysical research communications 29 28302479
2021 Impaired Sphingosine-1-Phosphate Synthesis Induces Preeclampsia by Deactivating Trophoblastic YAP (Yes-Associated Protein) Through S1PR2 (Sphingosine-1-Phosphate Receptor-2)-Induced Actin Polymerizations. Hypertension (Dallas, Tex. : 1979) 28 34865521
2016 Dihydroartemisinin restricts hepatic stellate cell contraction via an FXR-S1PR2-dependent mechanism. IUBMB life 28 27027402
2021 S1PR2 Inhibition Attenuates Allergic Asthma Possibly by Regulating Autophagy. Frontiers in pharmacology 24 33643037
2020 S1PR2 inhibitors potently reverse 5-FU resistance by downregulating DPD expression in colorectal cancer. Pharmacological research 24 32088343
2017 S1PR2 antagonist protects endothelial cells against high glucose-induced mitochondrial apoptosis through the Akt/GSK-3β signaling pathway. Biochemical and biophysical research communications 23 28676392
2020 MiR-126 on mice with coronary artery disease by targeting S1PR2. European review for medical and pharmacological sciences 22 32016996
2023 Liver sinusoidal endothelial S1pr2 regulates experimental liver fibrosis through YAP/TGF-β signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21 37039817
2023 S1PR2/Wnt3a/RhoA/ROCK1/β-catenin signaling pathway promotes diabetic nephropathy by inducting endothelial mesenchymal transition and impairing endothelial barrier function. Life sciences 21 37307963
2022 Conjugated Bile Acids Accelerate Progression of Pancreatic Cancer Metastasis via S1PR2 Signaling in Cholestasis. Annals of surgical oncology 21 36396870
2019 Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1. Liver international : official journal of the International Association for the Study of the Liver 20 30664326
2023 S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome. Chemico-biological interactions 16 37169277
2022 The function of Sphingosine-1-phosphate receptor 2 (S1PR2) in maintaining intestinal barrier and inducing ulcerative colitis. Bioengineered 16 35707833
2020 S1PR2 Knockdown Promotes Migration and Invasion in Multiple Myeloma Cells via NF-κB Activation. Cancer management and research 16 32922084
2018 C16‑ceramide and sphingosine 1‑phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation. Oncology reports 16 30226616
2015 Characterizing the diversity of active bacteria in soil by comprehensive stable isotope probing of DNA and RNA with H218 O. MicrobiologyOpen 16 25650291
2015 Sphingosine 1-phosphate regulates IL-8 expression and secretion via S1PR1 and S1PR2 receptors-mediated signaling in extravillous trophoblast derived HTR-8/SVneo cells. Placenta 16 26321412
2001 Genomic analysis of a mouse model of immunoglobulin A nephropathy reveals an enhanced PDGF-EDG5 cascade. The pharmacogenomics journal 16 11908758
2024 S1PR2 participates in intestinal injury in severe acute pancreatitis by regulating macrophage pyroptosis. Frontiers in immunology 15 38827741
2024 Overexpression of endothelial S1pr2 promotes blood-brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models. Frontiers in pharmacology 14 39679379
2021 Hirudin, a thrombin inhibitor, attenuates TGF-β-induced fibrosis in renal proximal tubular epithelial cells by inhibition of protease-activated receptor 1 expression via S1P/S1PR2/S1PR3 signaling. Experimental and therapeutic medicine 14 34815755
2024 Taurine-conjugated bile acids and their link to hepatic S1PR2 play a significant role in hepatitis C-related liver disease. Hepatology communications 13 38967598
2023 S1PR2 is Important for Cigarette Smoke-induced Pyroptosis in Human Bronchial Epithelial Cells. Archives of medical research 13 36990889
2017 The anti-ErbB2 antibody H2-18 and the pan-PI3K inhibitor GDC-0941 effectively inhibit trastuzumab-resistant ErbB2-overexpressing breast cancer. Oncotarget 13 28881779
1998 A putative G-protein-coupled receptor, H218, is down-regulated during the retinoic acid-induced differentiation of F9 embryonal carcinoma cells. Experimental cell research 13 9521849
2024 Electroacupuncture Alleviates Cerebral Ischemia-reperfusion Injury by Regulating the S1PR2/TLR4/NLRP3 Signaling Pathway via m6A Methylation of lncRNA H19. Current neurovascular research 12 38409728
2023 Enhanced Activation of the S1PR2-IL-1β-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats. International journal of molecular sciences 12 38139078
2023 Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling. Acta pharmacologica Sinica 11 37726422
2023 S1PR2 inhibition mitigates cognitive deficit in diabetic mice by modulating microglial activation via Akt-p53-TIGAR pathway. International immunopharmacology 11 38011768
2024 Lack of S1PR2 in Macrophage Ameliorates Sepsis-associated Lung Injury through Inducing IL-33-mediated Type 2 Immunity. American journal of respiratory cell and molecular biology 10 38061028
2022 Profiling of bile acids and activated receptor S1PR2 in gingival tissues of periodontitis patients. Journal of periodontology 10 36193723
2020 Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation. Acta pharmacologica Sinica 10 32647340
2020 Spatiotemporal Expression of SphK1 and S1PR2 in the Hippocampus of Pilocarpine Rat Model and the Epileptic Foci of Temporal Lobe Epilepsy. Frontiers in cell and developmental biology 10 33134289
2016 FTY720P inhibits hepatic Na(+)-K(+) ATPase via S1PR2 and PGE2. Biochemistry and cell biology = Biochimie et biologie cellulaire 10 27501354
2022 circSSU72 Promotes Cell Proliferation, Migration and Invasion of Papillary Thyroid Carcinoma Cells by Targeting miR-451a/S1PR2 Axis. Frontiers in cell and developmental biology 9 35372340
2022 Sphingosine-1-Phosphate Protects Against the Development of Cardiac Remodeling via Sphingosine Kinase 2 and the S1PR2/ERK Pathway. Current medical science 9 35963947
2021 Bivalirudin Attenuates Thrombin-Induced Endothelial Hyperpermeability via S1P/S1PR2 Category: Original Articles. Frontiers in pharmacology 9 34413778
2021 Novel 5-fluorouracil sensitizers for colorectal cancer therapy: Design and synthesis of S1P receptor 2 (S1PR2) antagonists. European journal of medicinal chemistry 9 34688013
2020 Nogo-A/S1PR2 Signaling Pathway Inactivation Decreases Microvascular Damage and Enhances Microvascular Regeneration in PDMCI Mice. Neuroscience 9 33039527
2016 S1PR2 deficiency in DLBCL: a FOXy connection. Blood 9 26989186
2023 S1P Released by SGPL1-Deficient Astrocytes Enhances Astrocytic ATP Production via S1PR2,4, Thus Keeping Autophagy in Check: Potential Consequences for Brain Health. International journal of molecular sciences 8 36902011
2021 Exenatide regulates inflammation and the production of reactive oxygen species via inhibition of S1PR2 synthesis. Advances in clinical and experimental medicine : official organ Wroclaw Medical University 8 33984196
2018 FTY720P inhibits the Na+/K+ ATPase in Caco-2 cells via S1PR2: PGE2 and NO are along the signaling pathway. Life sciences 8 30439376
2021 Effects of S1PR2 antagonist on blood pressure and angiogenesis imbalance in preeclampsia rats. Molecular medicine reports 7 33880585
2019 Regulation of S1PR2 by the EBV oncogene LMP1 in aggressive ABC-subtype diffuse large B-cell lymphoma. The Journal of pathology 7 30666658
2019 Evaluation of S1PR1, pSTAT3, S1PR2, FOXP1 Expression in Aggressive, Mature B Cell Lymphomas. Journal of hematopathology 7 31404445
2018 The conserved p.Arg108 residue in S1PR2 (DFNB68) is fundamental for proper hearing: evidence from a consanguineous Iranian family. BMC medical genetics 7 29776397
2022 Design, synthesis, and evaluation of JTE-013 derivatives as novel potent S1PR2 antagonists for recovering the sensitivity of colorectal cancer to 5-fluorouracil. Bioorganic chemistry 6 36527992

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