Affinage

RSU1

Ras suppressor protein 1 · UniProt Q15404

Length
277 aa
Mass
31.5 kDa
Annotated
2026-06-10
31 papers in source corpus 16 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RSU1 is a leucine-rich repeat (LRR) scaffolding protein that integrates integrin-based cell adhesion with Ras-family signaling to control cell spreading, migration, growth, and cytoskeletal organization (PMID:1508180, PMID:15878342, PMID:23765260). It was first identified as a selective suppressor of v-Ras transformation that inhibits cell growth, with LRRs homologous to the Ras-activated regulatory region of yeast adenylyl cyclase (PMID:1508180). Across multiple cell systems RSU1 reshapes Ras-downstream kinase outputs—enhancing and sustaining ERK activation, inhibiting JNK, and inducing the CDK inhibitor p21 while suppressing AKT activity (PMID:8816460, PMID:10470855, PMID:10930091). Mechanistically, RSU1 docks at focal adhesions through a direct interaction between its LRR solenoid and the LIM5 domain of PINCH1 (but not PINCH2), an interaction resolved by crystallography that shows RSU1 wrapping the C-terminal region of PINCH1 and blocking PINCH1–actin binding to negatively modulate IPP-complex-mediated F-actin bundling (PMID:15878342, PMID:33587032). RSU1 is required for focal adhesion integrity, stress fiber formation, adhesion, spreading and EGF-induced migration, and it stabilizes PINCH1 protein levels (PMID:23765260). Independent of focal adhesion structure, RSU1 drives a MKK4–p38–ATF2 axis that promotes ATF2 binding to the PTEN promoter, raising PTEN expression to restrain AKT, while its loss permits AKT to phosphorylate and inactivate MKK4 (PMID:23765260, PMID:30680530). Upon cell–ECM detachment RSU1 partitions to membrane lipid rafts and binds prohibitin-2 (PHB2) through its N-terminal LRR region to downregulate ERK signaling (PMID:33853759). In invertebrate models RSU1 acts downstream of integrin and upstream of Rac1 to organize the actin cytoskeleton and behavior, promotes α-actinin-dependent actin bundling, sustains M-line and dense body integrity in aging muscle via its UNC-97/PINCH interaction, and prevents illegitimate extrasynaptic acetylcholine receptor clustering (PMID:22467865, PMID:26170296, PMID:27307240, PMID:32461202, PMID:38784006).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1992 Medium

    Established RSU1 as a candidate negative regulator of Ras signaling, answering whether a novel LRR protein could antagonize oncogenic transformation.

    Evidence Expression cloning and ectopic cDNA expression in NIH 3T3 fibroblasts with v-Ras/v-Mos/v-Src selectivity controls and sequence homology analysis

    PMID:1508180

    Open questions at the time
    • No direct biochemical Ras interaction demonstrated
    • Molecular mechanism of suppression unresolved
  2. 1999 Medium

    Defined how RSU1 rebalances Ras-downstream kinase outputs, showing it enhances/sustains ERK while inhibiting JNK and inducing growth-arrest markers.

    Evidence Kinase activity assays, in vitro Raf-1 binding, and inducible/stable expression in Cos1, PC12, and MCF7 cells with neurite and soft-agar readouts

    PMID:10470855 PMID:10930091 PMID:8816460

    Open questions at the time
    • Raf-1 binding shown only in vitro
    • Mechanism linking RSU1 to GAP/SOS levels unclear
    • Concurrent ROCK and AKT effects not mechanistically connected
  3. 2005 High

    Identified the physical basis of RSU1's adhesion role by mapping a direct LRR-to-PINCH1-LIM5 interaction localizing RSU1 to focal adhesions.

    Evidence Yeast two-hybrid, subdomain mapping, GST pulldown, reciprocal Co-IP, confocal co-localization, and RNAi adhesion/kinase assays

    PMID:15878342

    Open questions at the time
    • Structural basis of binding not yet resolved
    • Functional separation of adhesion vs. growth roles unaddressed
  4. 2012 High

    Demonstrated in vivo that RSU1 provides a compensatory function for PINCH-ILK binding, revealing functional redundancy within the adhesion complex.

    Evidence Drosophila genetic epistasis combining PINCH(Q38A) and RSU-1 null alleles with synthetic lethality and localization controls

    PMID:22467865

    Open questions at the time
    • Molecular activity rescued by RSU1 not defined
    • Relevance to mammalian adhesion not tested here
  5. 2013 High

    Separated RSU1's structural adhesion role from its signaling role, showing PINCH1 binding is needed for focal adhesions/migration but not for p38 activation or spreading.

    Evidence siRNA depletion in MCF10A cells with confocal imaging, adhesion/migration assays, and reconstitution with a PINCH1-binding-defective mutant

    PMID:23765260

    Open questions at the time
    • Effector mediating PINCH1-independent spreading unknown
    • How RSU1 stabilizes PINCH1 protein unresolved
  6. 2015 High

    Placed RSU1 in a defined linear pathway between integrin and Rac1 controlling actin and behavior in vivo.

    Evidence Drosophila genetic epistasis with tissue-specific (mushroom body) knockouts and ethanol sedation/preference assays

    PMID:26170296

    Open questions at the time
    • Biochemical link from RSU1 to Rac1 not defined
    • Mammalian conservation of axis untested
  7. 2016 Medium

    Revealed a tissue function in receptor organization, showing RSU1 actively maintains dispersal of extrasynaptic acetylcholine receptors.

    Evidence C. elegans rsu-1 mutant receptor-distribution and NMJ imaging

    PMID:27307240

    Open questions at the time
    • Molecular mechanism preventing ectopic clustering unknown
    • Link to integrin/PINCH adhesion machinery not established
  8. 2019 High

    Resolved the RSU1->MKK4-p38-ATF2->PTEN->AKT axis, explaining how RSU1 transcriptionally controls PTEN to restrain AKT.

    Evidence siRNA depletion in MCF10A with phospho-Westerns, RT-PCR, and ChIP at the PTEN promoter

    PMID:30680530

    Open questions at the time
    • Upstream trigger of the axis at adhesions undefined
    • Direct vs. scaffolded role of RSU1 in MKK4 regulation unclear
  9. 2019 Medium

    Defined an LRR-subdomain requirement for actin bundling in vivo, linking specific repeats to α-actinin promotion and positioning RSU1 antagonistic to Ras in this context.

    Evidence C. elegans rsu-1 and RasLET-60 mutant analysis with LRR deletion mapping, actin imaging, and genetic epistasis

    PMID:32461202

    Open questions at the time
    • Direct RSU1-α-actinin interaction not biochemically shown
    • Reconciliation with PINCH1-mediated anti-bundling role unresolved
  10. 2020 High

    Identified a detachment-responsive RSU1-PHB2 lipid raft axis that downregulates ERK upon loss of ECM contact.

    Evidence Co-IP with domain mapping, RSU1 knockout, PHB2-fragment competition, lipid raft fractionation, and ERK phosphorylation assays

    PMID:33853759

    Open questions at the time
    • How detachment redistributes RSU1 to rafts unknown
    • Relationship to focal-adhesion-bound RSU1 pool unclear
  11. 2020 Low

    Identified microRNA regulation of RSU1 and a feedback loop coupling RSU1 levels to its own regulators in breast cancer cells.

    Evidence miRNA transfection in breast cancer lines with Western blot, database analysis, and p38/ATF2 readouts

    PMID:32751711

    Open questions at the time
    • No direct binding/luciferase validation of miRNA targeting described
    • Single-lab overexpression evidence
  12. 2021 High

    Provided the structural mechanism by which RSU1 negatively regulates F-actin bundling, showing the LRR solenoid blocks PINCH1-actin binding.

    Evidence X-ray crystallography of the Rsu1/PINCH1 complex with functional validation by RSU1 overexpression in HeLa cells

    PMID:33587032

    Open questions at the time
    • Dynamics of RSU1 regulation of IPP in adhesions not captured
    • How structural blockade reconciles with adhesion-promoting roles
  13. 2024 Medium

    Established an age-dependent muscle maintenance role requiring the RSU-1/PINCH interaction to preserve M-line and dense body integrity.

    Evidence C. elegans RSU-1 mutant analysis with UNC-97 co-localization imaging and locomotion assays in aging worms

    PMID:38784006

    Open questions at the time
    • Why dysfunction is age-specific unexplained
    • Molecular basis of structural maintenance undefined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RSU1 coordinates its distinct pools—focal-adhesion-bound PINCH1 complexes, detachment-induced PHB2/raft complexes, and the PTEN-transcriptional axis—into a unified mechanotransduction program remains unresolved.
  • No model integrating adhesion, ERK, and PTEN/AKT regulation
  • Direct RSU1-Ras biochemical relationship still undefined
  • Mammalian conservation of invertebrate Rac1/α-actinin axes untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0098772 molecular function regulator activity 4 GO:0008092 cytoskeletal protein binding 2
Localization
GO:0005856 cytoskeleton 3 GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1474244 Extracellular matrix organization 2 R-HSA-1643685 Disease 2
Partners
PHB2PINCH1RAF1UNC-97
Complex memberships
IPP (ILK-PINCH-Parvin) complex

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1992 RSU1 (rsp-1) was identified as a novel leucine-rich repeat protein capable of suppressing v-Ras-transformed phenotype when expressed in NIH 3T3 fibroblasts; it selectively inhibited v-Ras but not v-Mos or v-Src transformation, and inhibited cell growth. The protein contains leucine-based repeats homologous to the regulatory region of yeast adenylyl cyclase required for activation by Ras, suggesting involvement in Ras signal transduction. Expression cloning assay, ectopic cDNA expression in NIH 3T3 fibroblasts, protein sequence homology analysis Molecular and cellular biology Medium 1508180
1996 Increased Rsu-1 expression enhanced Erk-2 kinase activation and inhibited Jun kinase (JNK) activation in response to growth factors. In vitro binding assay detected direct interaction between Rsu-1 and Raf-1, suggesting Rsu-1 promotes Raf-1/ERK signaling at the expense of JNK activation. Rsu-1 expression also increased levels of SOS and p120 GAP but decreased Ras GTPase-activating activity of immunoprecipitated p120 GAP. Kinase activity assays (ERK-2 and JNK), co-transfection with HA-tagged kinases in Cos1 cells, in vitro binding assay (Rsu-1 to Raf-1) Molecular and cellular biology Medium 8816460
1999 Rsu-1 expression in PC12 cells enhanced NGF-induced neurite extension and sustained ERK kinase activation in response to NGF, while inhibiting Jun kinase activation. Rsu-1 expression also induced p21(WAF/CIP) expression and growth inhibition. Inducible transfection (MMTV promoter), kinase activity assays, neurite extension assay, Western blot for p21 Cell growth & differentiation Medium 10470855
2000 Ectopic Rsu-1 expression in MCF7 breast cancer cells elevated p21CIP CDK inhibitor levels, reduced anchorage-independent growth, enhanced ERK-2 kinase activation, decreased JNK activation, inhibited Rho-dependent ROCK activity, and abolished AKT activity under serum starvation. These results place Rsu-1 as a regulator of multiple Ras-downstream kinase pathways including ERK, JNK, ROCK, and AKT. Stable transfection (HA-tagged Rsu-1), kinase activity assays (ERK-2, JNK, ROK/ROCK, AKT), Western blot, soft agar colony assay Breast cancer research and treatment Medium 10930091
2005 Rsu-1 physically interacts with the LIM 5 domain of PINCH1 (but not PINCH2, which differs in LIM 5) via its leucine-rich repeat (LRR) region. Rsu-1 co-immunoprecipitates with PINCH1 and co-localizes with vinculin at focal adhesions in mammalian cells. RNAi-mediated depletion of Rsu-1 inhibited cell attachment and activated Jun and p38 stress kinases. Yeast two-hybrid screening, subdomain mapping, GST fusion protein pulldown, co-immunoprecipitation (reciprocal), confocal co-localization, RNAi knockdown with adhesion and kinase assays Experimental cell research High 15878342
2012 In Drosophila, genetic epistasis revealed a synthetic lethal interaction between a PINCH(Q38A) mutation (disrupting PINCH-ILK binding) and a null mutation in RSU-1, demonstrating a compensatory/redundant role for RSU-1 in maintaining viability when PINCH-ILK binding is compromised. This lethality was not due to PINCH mislocalization or destabilization. Transgenic Drosophila expressing PINCH(Q38A) point mutant combined with RSU-1 null allele; genetic epistasis/synthetic lethality analysis; localization by imaging Journal of cell science High 22467865
2013 siRNA-mediated depletion of Rsu1 in MCF10A mammary epithelial cells decreased focal adhesion number, altered distribution of β1 integrin, vinculin, talin, and paxillin, reduced adhesion, spreading, and EGF-induced migration, and eliminated actin stress fibers and caveolae. Rsu1 depletion also caused significant reduction in PINCH1 protein levels. Importantly, Rsu1 (but not PINCH1) was required for EGF-induced p38 MAP kinase phosphorylation and ATF2 activation. An Rsu1 mutant unable to bind PINCH1 failed to restore focal adhesions or migration but retained the ability to promote spreading and constitutive p38 activation. siRNA depletion, confocal microscopy, adhesion/migration assays, EGF stimulation, Western blot for kinase phosphorylation, reconstitution with PINCH1-binding-defective Rsu1 mutant Journal of cell communication and signaling High 23765260
2013 In hepatocellular carcinoma cell lines, increased Rsu-1 expression suppressed cell proliferation and migration, and these effects were mediated through suppression of Ras downstream signaling via RhoGTPase proteins rather than through direct effects on Ras activation itself. Rsu-1 transfection in HCC cell lines, proliferation and migration assays, Western blot for RhoGTPase signaling PloS one Low 24058607
2015 In Drosophila, Rsu1 acts downstream of integrin and upstream of Rac1 GTPase to regulate the actin cytoskeleton. Loss of Rsu1 reduces sensitivity to ethanol-induced sedation, and Rsu1 is required in the adult nervous system (mushroom bodies) for normal ethanol preference acquisition, establishing an integrin/Rsu1/Rac1/actin signaling axis in behavior. Genetic epistasis in Drosophila (integrin→Rsu1→Rac1 pathway), tissue-specific knockouts (mushroom body-specific), ethanol sedation and preference assays, actin cytoskeleton analysis Proceedings of the National Academy of Sciences of the United States of America High 26170296
2016 In C. elegans muscle cells, RSU-1 is required to prevent illegitimate extrasynaptic acetylcholine receptor (AChR) clustering. Loss of RSU-1 causes ectopic AChR clusters to form progressively at extrasynaptic membranes, reducing synaptic AChR content, while neuromuscular junctions differentiate normally. RSU-1 thus actively maintains dispersal of extrasynaptic receptors independently of synaptic cues. C. elegans rsu-1 mutant analysis, receptor distribution imaging, genetic/developmental analysis of NMJ structure The Journal of neuroscience Medium 27307240
2019 In C. elegans vulval muscle, RSU-1 is required for proper actin bundle organization; loss of RSU-1 causes blister-like membrane protrusions and disorganized actin bundles. The fifth-to-seventh leucine-rich repeats of RSU-1 are required to promote the actin-bundling protein α-actinin for actin bundle stabilization. Genetic interaction showed that RasLET-60 depletion diminished actin-bundle defects in rsu-1 mutants, placing RSU-1 downstream of or antagonistic to Ras in this context. C. elegans rsu-1 and RasLET-60 mutant analysis, subdomain deletion mapping of LRR region, actin imaging, genetic epistasis G3 (Bethesda, Md.) Medium 32461202
2019 Rsu1 depletion in MCF10A cells increased AKT1 phosphorylation; ectopic Rsu1 inhibited AKT1 phosphorylation. Rsu1 depletion allowed AKT1 to phosphorylate MKK4 on serine 80, blocking MKK4 activity. Rsu1 depletion also reduced PTEN RNA. ChIP analysis revealed Rsu1 depletion prevented ATF2 binding to a positive regulatory site in the PTEN promoter and enhanced cJun binding to a negative regulatory site, thereby reducing PTEN expression. This establishes an Rsu1→MKK4-p38-ATF2/cJun→PTEN→AKT signaling axis. siRNA depletion, Western blot (AKT phosphorylation, MKK4 phosphorylation), RT-PCR (PTEN RNA), chromatin immunoprecipitation (ChIP) at PTEN promoter Journal of cell communication and signaling High 30680530
2021 Crystal structures of the Rsu1/PINCH1 complex revealed that the leucine-rich repeats (LRRs) of Rsu1 form a solenoid structure that tightly associates with the C-terminal region of PINCH1. Structural analysis showed that this Rsu1-PINCH1 interaction blocks IPP complex-mediated F-actin bundling by disrupting PINCH1 binding to actin. Overexpressing Rsu1 in HeLa cells impaired stress fiber formation and cell spreading, consistent with negative modulation of F-actin bundling. X-ray crystallography (crystal structure of Rsu1/PINCH1 complex), structural analysis, Rsu1 overexpression in HeLa cells with actin imaging and cell spreading assay eLife High 33587032
2020 RSU1 interacts with prohibitin-2 (PHB2), a membrane lipid raft component. The major RSU1-binding site on PHB2 maps to amino acids 150–206 in the PHB/SPFH domain C-terminal region, while multiple sites in the N-terminal LRR region of RSU1 mediate PHB2 binding. Cell-ECM detachment increases RSU1 association with membrane lipid rafts and interaction with PHB2. Knockout of RSU1 or disruption of RSU1-PHB2 interaction (by overexpressing PHB2 fragment aa 150–206) suppressed cell-ECM detachment-induced downregulation of ERK signaling. A PHB2-binding-defective RSU1 mutant (N-terminal LRR deletion) failed to restore ERK signaling, establishing RSU1-PHB2 as a signaling axis linking ECM detachment to ERK downregulation. Co-immunoprecipitation, domain mapping (deletion mutants), RSU1 knockout, PHB2 fragment overexpression competition assay, ERK phosphorylation assay, lipid raft fractionation The Journal of biological chemistry High 33853759
2020 miR-182-5p and miR-409-3p directly target RSU1 mRNA, reducing RSU1 and PINCH1 protein levels in breast cancer cell lines and inhibiting ATF2 activation of PTEN expression. miR-221-3p and miR-130a-3p also target RSU1 and PINCH1; conversely, RSU1 depletion itself increases miR-221-3p and miR-130a-3p, forming a feedback regulatory loop. miR transfection in breast cancer cell lines, Western blot, database analysis, p38 MAP kinase and ATF2 activation assays International journal of molecular sciences Low 32751711
2024 In C. elegans body wall muscle, RSU-1 co-localizes with UNC-97/PINCH at the dense body and M-line. The interaction between RSU-1 and UNC-97/PINCH is essential for RSU-1 to modulate locomotion in aging worms, preserve filament structure, and sustain M-line and dense body integrity during aging. RSU-1 mutants show muscle dysfunction specifically in aging, not young, worms. C. elegans RSU-1 mutant analysis, co-localization imaging (RSU-1 with UNC-97), locomotion assays in aging worms, muscle structure imaging iScience Medium 38784006

Source papers

Stage 0 corpus · 31 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1992 Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation. Molecular and cellular biology 91 1508180
2005 The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions. Experimental cell research 70 15878342
2015 Rsu1 regulates ethanol consumption in Drosophila and humans. Proceedings of the National Academy of Sciences of the United States of America 55 26170296
1996 Increased expression of the Ras suppressor Rsu-1 enhances Erk-2 activation and inhibits Jun kinase activation. Molecular and cellular biology 49 8816460
2017 Identification of Ras suppressor-1 (RSU-1) as a potential breast cancer metastasis biomarker using a three-dimensional in vitro approach. Oncotarget 38 28423706
1995 The Ras suppressor RSU-1 localizes to 10p13 and its expression in the U251 glioblastoma cell line correlates with a decrease in growth rate and tumorigenic potential. Oncogene 36 7624154
2019 Ras suppressor-1 (RSU-1) promotes cell invasion in aggressive glioma cells and inhibits it in non-aggressive cells through STAT6 phospho-regulation. Scientific reports 33 31123330
2013 Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis. PloS one 33 24058607
2000 Ectopic expression of Rsu-1 results in elevation of p21CIP and inhibits anchorage-independent growth of MCF7 breast cancer cells. Breast cancer research and treatment 31 10930091
2013 Rsu1 contributes to regulation of cell adhesion and spreading by PINCH1-dependent and - independent mechanisms. Journal of cell communication and signaling 30 23765260
2017 Suppression of microRNA-629 enhances sensitivity of cervical cancer cells to 1'S-1'-acetoxychavicol acetate via regulating RSU1. OncoTargets and therapy 25 28356756
2019 Inhibition of Breast Cancer Cell Invasion by Ras Suppressor-1 (RSU-1) Silencing Is Reversed by Growth Differentiation Factor-15 (GDF-15). International journal of molecular sciences 24 30621163
2002 Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas. Journal of neuro-oncology 21 12510772
2012 A crucial role for Ras suppressor-1 (RSU-1) revealed when PINCH and ILK binding is disrupted. Journal of cell science 20 22467865
2017 MicroRNA-409-5p is upregulated in breast cancer and its downregulation inhibits cancer development through downstream target of RSU1. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 17 28459205
2023 Circular RNA RSU1 promotes retinal vascular dysfunction by regulating miR-345-3p/TAZ. Communications biology 14 37443201
2021 Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics. eLife 14 33587032
1999 The ras suppressor, RSU-1, enhances nerve growth factor-induced differentiation of PC12 cells and induces p21CIP expression. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 14 10470855
2019 Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform. Scientific reports 13 31296919
2019 Coordinated Expression of Ras Suppressor 1 (RSU-1) and Growth Differentiation Factor 15 (GDF15) Affects Glioma Cell Invasion. Cancers 12 31412547
2017 Ras Suppressor-1 (RSU-1) in Cancer Cell Metastasis: Friend or Foe? Critical reviews in oncogenesis 12 29604901
2020 Ras Suppressor-1 (RSU1) in Cancer Cell Metastasis: A Tale of a Tumor Suppressor. International journal of molecular sciences 10 32517326
2018 Purification and Characterization of Pasteuricin Produced by Staphylococcus pasteuri RSP-1 and Active against Multidrug-Resistant Staphylococcus aureus. Journal of food protection 9 30280936
2016 Preventing Illegitimate Extrasynaptic Acetylcholine Receptor Clustering Requires the RSU-1 Protein. The Journal of neuroscience : the official journal of the Society for Neuroscience 9 27307240
2014 Rsu1 contributes to cell adhesion and spreading in MCF10A cells via effects on P38 map kinase signaling. Cell adhesion & migration 9 25482629
2020 MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines. International journal of molecular sciences 7 32751711
2020 RSU-1 interaction with prohibitin-2 links cell-extracellular matrix detachment to downregulation of ERK signaling. The Journal of biological chemistry 6 33853759
2019 Rsu1-dependent control of PTEN expression is regulated via ATF2 and cJun. Journal of cell communication and signaling 5 30680530
2020 RSU-1 Maintains Integrity of Caenorhabditis elegans Vulval Muscles by Regulating α-Actinin. G3 (Bethesda, Md.) 3 32461202
2025 RSU1 Mediates Caco-2 Colorectal Cancer Cells Proliferation and Migration via PI3K/AKT Signaling Pathway. Cell biochemistry and biophysics 1 40544194
2024 RSU-1 regulates the integrity of dense bodies in muscle cells of aging Caenorhabditis elegans. iScience 0 38784006

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