Affinage

RPS6KA5

Ribosomal protein S6 kinase alpha-5 · UniProt O75582

Length
802 aa
Mass
89.9 kDa
Annotated
2026-06-10
100 papers in source corpus 38 papers cited in narrative 39 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPS6KA5 (MSK1) is a nuclear serine/threonine kinase that couples the ERK1/2 and p38 MAPK cascades to chromatin remodeling and transcription, serving as a terminal effector that converts mitogenic and stress signals into immediate-early gene induction, inflammatory control, and synaptic plasticity (PMID:9687510, PMID:11909979, PMID:12773393). It is built from two kinase domains in a single polypeptide and is activated by a multi-site phosphorylation cascade: ERK1/2 or p38 phosphorylate the C-terminal kinase domain (Thr581, Ser360, and Thr700), which then autophosphorylates the N-terminal catalytic domain (Ser212, Ser376), with the N-terminal domain held in an autoinhibited conformation by an intramolecular β-sheet seen crystallographically and relieved through this cascade independently of PDK1 (PMID:15274926, PMID:15568999, PMID:17117922). Once active, MSK1 phosphorylates CREB (Ser133) and ATF1 to drive c-fos and other immediate-early genes (PMID:9687510, PMID:11018520, PMID:11909979), and phosphorylates histone H3 (Ser10, Ser28) and HMGN1/HMG-14 to execute the nucleosomal response (PMID:10469656, PMID:11441012, PMID:12773393). MSK1 is recruited to target promoters by transcription factors such as Elk-1, CREB, and NF-κB, where its histone phosphorylation creates 14-3-3 docking sites that enable BRG1/SWI/SNF nucleosome remodeling and supports H3K4 methylation by the KMT2A/MLL1 complex with which it associates (PMID:20129940, PMID:20089855, PMID:27895715). Through phosphorylation of NF-κB p65 (Ser276) and induction of DUSP1, IL-10, and IL-1ra, MSK1 limits pro-inflammatory cytokine output, and MSK1/2-deficient mice are hypersensitive to endotoxic shock (PMID:12628924, PMID:18690222, PMID:19922413). The kinase additionally phosphorylates STAT3 (Ser727), Bad (Ser112), RARα, ER81, and β-catenin, linking it to apoptosis, nuclear receptor signaling, and oncogenic transcription (PMID:11553624, PMID:11983683, PMID:12569367, PMID:19078967, PMID:27196759). In neurons, MSK1 is the major CREB kinase for contextual fear memory and mediates BDNF-driven Arc/Arg3.1 and miR-212/132 induction underlying synaptic scaling and plasticity (PMID:17196532, PMID:20307261, PMID:22993422). Glucocorticoid receptor binding to activated MSK1 drives its CRM1-dependent nuclear export, removing it from inflammatory promoters as an anti-inflammatory mechanism (PMID:18511904).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1998 High

    Established the founding identity of MSK1 as a dual-kinase-domain nuclear enzyme directly activated by both ERK and p38 and acting as a high-affinity CREB kinase, defining it as a convergence point for mitogenic and stress signaling.

    Evidence In vitro kinase assays, inhibitor epistasis (PD98059, SB203580), and localization across multiple cell lines

    PMID:9687510

    Open questions at the time
    • In vitro substrate preference does not establish the full in vivo substrate set
    • Activation mechanism of the tandem kinase domains not yet resolved
  2. 1999 Medium

    Proposed MSK1 as the kinase executing the nucleosomal response by phosphorylating histone H3 Ser10 and HMG-14 downstream of both MAPK arms, linking signaling to chromatin.

    Evidence In vitro kinase assay plus H89-based pharmacology in intact cells

    PMID:10469656

    Open questions at the time
    • H89 is not fully selective; genetic confirmation was needed
    • Single lab at this stage
  3. 2000 High

    Provided genetic proof that MSK1 is required for mitogen-induced CREB/ATF1 phosphorylation, separating MSK1-dependent from PKA-dependent CREB activation.

    Evidence MSK1 gene-disruption in mouse ES cells with phospho-specific immunoblotting

    PMID:11018520

    Open questions at the time
    • Possible MSK2 compensation not addressed in single knockout
    • Downstream transcriptional consequences not quantified here
  4. 2001 High

    Extended the MSK1 substrate repertoire to histone H3 Ser28, STAT3 Ser727, and apoptotic regulation, showing direct phosphorylation in vitro and dependence in cells via kinase-dead mutants.

    Evidence In vitro kinase assays, kinase-dead/dominant-negative MSK1 mutants, H89, UV-irradiation cell models

    PMID:11441012 PMID:11553624

    Open questions at the time
    • Physiological stimuli beyond UV irradiation not tested for each substrate
    • Single-lab findings at this stage
  5. 2002 High

    Double-knockout studies established MSK1/MSK2 as the major kinases for stress-induced CREB/ATF1 and identified Bad Ser112 as a substrate, defining MSK1's role in immediate-early gene transcription and apoptotic gating.

    Evidence MSK1/MSK2 single and double knockout fibroblasts, in vitro kinase assay, gene expression and phospho readouts

    PMID:11909979 PMID:11983683

    Open questions at the time
    • Mitogen-induced transcription was only modestly affected, leaving redundant pathways unexplained
    • Bad phosphorylation was tested mainly under UVB stress
  6. 2003 High

    Defined MSK1 as the dominant in vivo H3/HMG-14 kinase and a direct NF-κB p65 Ser276 kinase, embedding it in inflammatory transcription, and broadened its targets to ER81 and the TGF-β/Smad axis.

    Evidence MSK1/MSK2 double-knockout mice, reciprocal Co-IP, in vitro kinase assays, mutagenesis, reporter assays

    PMID:12569367 PMID:12628924 PMID:12769834 PMID:12773393

    Open questions at the time
    • How MSK1 is selectively recruited to specific promoters not yet defined
    • ER81/CBP-p300 and Smad3-p300 links rest on single-lab data
  7. 2005 High

    Resolved the activation mechanism, defining the ordered multi-site phosphorylation cascade (Thr581/Ser360 → autophosphorylation of Ser212/Ser376) that is PDK1-independent, distinguishing MSK1 from RSKs.

    Evidence Alanine-scanning mutagenesis of ≥6 sites, mass spectrometry, in vitro and cellular kinase assays; with a parallel crystal structure of the autoinhibited N-terminal domain

    PMID:15274926 PMID:15568999

    Open questions at the time
    • Full-length active-state structure not determined
    • Dynamics of inter-domain communication not directly visualized
  8. 2005 Medium

    Placed MSK1 in physiological neuronal and cAMP-driven contexts, showing photic activation in the SCN clock circuit and a PKA→p38→MSK1 route to CREB transcription, and confirmed strict nuclear confinement in brain.

    Evidence In vivo phospho-IHC, MEK/PACAP-receptor pharmacology, dominant-negative mutants, reporter assays, brain immunolocalization

    PMID:15893597 PMID:15930378 PMID:16125054

    Open questions at the time
    • In vivo epistasis relies on pharmacology rather than genetics
    • Single-lab observations
  9. 2007 Medium

    Refined activation by identifying Thr700 as an upstream-phosphorylated regulatory site controlling Thr581 stability, and confirmed MSK1 as the major Ca2+-induced Bad kinase and CREB kinase for contextual memory.

    Evidence Precursor-ion-scanning MS, mutagenesis, in vitro kinase assays, siRNA knockdown, adenylyl cyclase knockout mice, fear conditioning

    PMID:17117922 PMID:17196532 PMID:17663748

    Open questions at the time
    • Proposed C-terminal autoinhibitory helix mechanism inferred indirectly
    • Behavioral causality of MSK1 not isolated from broader cAMP signaling
  10. 2008 High

    Demonstrated that MSK1/2 enforce anti-inflammatory feedback by inducing DUSP1 and IL-10 via promoter-bound phospho-CREB/ATF1, and uncovered GR-driven CRM1-dependent nuclear export as a mechanism to silence MSK1 at inflammatory promoters.

    Evidence MSK1/MSK2 knockout mice and macrophages, ChIP, cytokine ELISA, endotoxic shock model; Co-IP, leptomycin B, subcellular fractionation

    PMID:18511904 PMID:18690222

    Open questions at the time
    • Direct GR-MSK1 interface not mapped
    • Promoter selectivity of MSK1 recruitment incompletely defined
  11. 2009 Medium

    Mechanistically connected MSK1 to chromatin remodeling and nuclear receptor licensing: H3 phosphorylation recruits 14-3-3/BRG1-SWI/SNF, and RARα Ser369 phosphorylation enables TFIIH recruitment, while validating p65 Ser276 as a distinct ROS-driven NF-κB pathway.

    Evidence Sequential Co-IP and ChIP, in vitro kinase assays, RARα/RelA site mutants, siRNA, knockout mice (IL-1ra)

    PMID:18511904 PMID:19078967 PMID:19706715 PMID:19922413 PMID:20129940

    Open questions at the time
    • Order and stoichiometry of the 14-3-3/SWI-SNF complex assembly not fully resolved
    • Several findings from single labs
  12. 2012 High

    Established a reconstituted mechanism for activator-directed H3 phosphorylation at c-fos and defined MSK1's requirement for synaptic scaling, BDNF-driven Arc and miR-212/132 induction, embedding it in plasticity.

    Evidence Cell-free chromatin reconstitution, MSK1 kinase-dead knock-in mice with rescue, electrophysiology, ChIP, deep sequencing

    PMID:20089855 PMID:20307261 PMID:22993422 PMID:28593137

    Open questions at the time
    • Arc induction was shown to be CREB-Ser133-independent, indicating undefined alternative MSK1 outputs
    • Causal chain from H3 phosphorylation to GluA1 surface expression not fully traced
  13. 2023 Medium

    Positioned MSK1 as a disease-relevant transcriptional node controlling protein abundance and tumor behavior, including SCA1-causing ATXN1 levels, breast cancer metastatic dormancy via GATA3/FOXA1, and growth/survival in glioblastoma, gastric, and pancreatic cancers.

    Evidence Drosophila and mouse genetic screens, in vivo genome-wide shRNA screen, ChIP, shRNA depletion, phospho-substrate identification, xenograft/intracranial/PDAC models, pharmacological inhibition

    PMID:23719381 PMID:27196759 PMID:29358704 PMID:32041943 PMID:37951219

    Open questions at the time
    • β-catenin Ser552 and DDX17 as direct MSK1 substrates rest on single studies
    • Therapeutic combinations validated only in preclinical models

Open questions

Synthesis pass · forward-looking unresolved questions
  • How MSK1 achieves promoter and substrate selectivity among its many nuclear targets across distinct physiological contexts remains unresolved.
  • No full-length active-state structure explaining substrate discrimination
  • Rules governing context-specific recruitment (transcription factor vs chromatin) not defined
  • Human disease-causing mutations in RPS6KA5 not established in the corpus

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 6 GO:0042393 histone binding 4 GO:0016740 transferase activity 3 GO:0140110 transcription regulator activity 3
Localization
GO:0005634 nucleus 2 GO:0005829 cytosol 2
Pathway
R-HSA-4839726 Chromatin organization 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-112316 Neuronal System 3 R-HSA-162582 Signal Transduction 3 R-HSA-168256 Immune System 3
Partners
14-3-3BRG1 (SMARCA4)CBP/P300CREBGR (NR3C1)KMT2ANF-KB P65 (RELA)STAT3
Complex memberships
KMT2A/MLL1 methyltransferase complexSWI/SNF (BRG1) remodeling complex

Evidence

Reading pass · 39 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 MSK1 (RPS6KA5) is a nuclear serine/threonine kinase containing two kinase domains in a single polypeptide that is directly activated in vitro by ERK2 (MAPK/ERK) and SAPK2/p38, and phosphorylates CREB at Ser133 with a Km far lower than PKA, MAPKAP-K1, or MAPKAP-K2. Growth factor/phorbol ester-induced activation requires the MAPK/ERK cascade (blocked by PD 98059), while stress-induced activation requires SAPK2/p38 (blocked by SB 203580). MSK1 is localized in the nucleus of both unstimulated and stimulated cells. In vitro kinase assay, pharmacological inhibitor experiments in 293/HeLa/PC12/SK-N-MC cells, subcellular localization, mutagenesis The EMBO journal High 9687510
1999 MSK1 is proposed as the major kinase mediating the nucleosomal response (histone H3 Ser10 and HMG-14 phosphorylation) downstream of both ERK and p38 MAPK pathways: it efficiently phosphorylates H3 and HMG-14 at physiologically relevant sites, and its activity toward these substrates is uniquely sensitive to H89 inhibition, which selectively inhibits the nucleosomal response in intact cells without affecting MAPK activation. In vitro kinase assay, pharmacological inhibition (H89) in intact cells, immunoblot with phospho-specific antibodies The EMBO journal Medium 10469656
2000 MSK1 is required for mitogen-induced phosphorylation of CREB at Ser133 and ATF1 at Ser63 in mouse embryonic stem cells; MSK1-knockout ES cells show abolished TPA- and EGF-induced CREB/ATF1 phosphorylation while basal and PKA-driven (forskolin) phosphorylation remains intact. MSK1 gene-disruption (knockout) in mouse ES cells, phospho-specific immunoblotting FEBS letters High 11018520
2001 MSK1 mediates UVB-induced phosphorylation of histone H3 at Ser28 in vivo; H89 (a selective MSK1 inhibitor) blocks this phosphorylation without affecting MAP kinases; MSK1 phosphorylates Ser28 on histone H3 and chromatin in vitro; dominant-negative N- or C-terminal kinase-dead MSK1 mutants block UVB-induced H3-Ser28 phosphorylation in cells. In vitro kinase assay, pharmacological inhibition (H89), dominant-negative MSK1 transfection, phospho-specific immunoblot The Journal of biological chemistry High 11441012
2001 MSK1 phosphorylates STAT3 at Ser727 in vitro and in vivo following UVA irradiation; active MSK1 (but not ERKs or p38) directly phosphorylates STAT3 Ser727 in vitro; kinase-dead MSK1 mutants and H89 suppress UVA-induced Ser727 phosphorylation in cells. In vitro kinase assay, dominant-negative/kinase-dead mutant transfection, pharmacological inhibition (H89), immunoblot The Journal of biological chemistry High 11553624
2002 MSK1 and MSK2 are required for stress- and mitogen-induced phosphorylation of CREB (Ser133) and ATF1 in primary mouse embryonic fibroblasts; double-knockout of MSK1 and MSK2 results in ~50% reduction in c-fos and junB transcription in response to stress stimuli but minimal reduction in response to mitogens. MSK1/MSK2 single and double knockout mouse-derived fibroblasts, phospho-specific immunoblotting, gene expression assays Molecular and cellular biology High 11909979
2002 MSK1 phosphorylates Bad at Ser112 in vitro and is required for UVB-induced Bad Ser112 phosphorylation in vivo; cells expressing kinase-dead N- or C-terminal MSK1 mutants are defective for UVB-induced Bad phosphorylation; phosphorylation at Ser112 promotes dissociation of Bad from Bcl-XL. In vitro kinase assay, dominant-negative (kinase-dead) MSK1 mutant transfection, immunoblot with phospho-specific antibodies The Journal of biological chemistry High 11983683
2003 MSK1 and MSK2 are the major kinases mediating mitogen- and stress-induced phosphorylation of histone H3 and HMG-14 in fibroblasts; MSK1/MSK2 double-knockout mouse embryonic fibroblasts show severely reduced or abolished H3 and HMG-14 phosphorylation; H3 acetylation is unimpaired, and immediate-early genes can still be induced but at reduced efficiency. MSK1/MSK2 double-knockout mice, phospho-specific immunoblotting, immediate-early gene expression assays The EMBO journal High 12773393
2003 MSK1 associates with NF-κB p65 in a stimulus-dependent manner and phosphorylates p65 at Ser276 in the nucleus; this phosphorylation is required for TNF-induced NF-κB transactivation; mutational analysis identifies Ser276 as the MSK1 target on p65. Co-immunoprecipitation, in vitro kinase assay, site-directed mutagenesis of p65, reporter gene assays, pharmacological inhibition The EMBO journal High 12628924
2003 MSK1 is required for full c-fos promoter activation and CREB phosphorylation in response to lysophosphatidic acid (LPA) in mouse ES cells, acting downstream of the ERK pathway. MSK1-knockout ES cells, promoter-reporter assay, phospho-specific immunoblotting BMC molecular biology Medium 12769834
2003 MSK1 phosphorylates and activates the transcription factor ER81; MSK1 targets two serine residues on ER81 and enhances ER81-dependent transcription, particularly downstream of p38-MAPK. MSK1 also interacts with co-activators CBP and p300 and stimulates the transactivation domain of CBP. In vitro kinase assay, mutagenesis of ER81 phosphorylation sites, reporter gene assay, Co-IP with CBP/p300 Oncogene Medium 12569367
2004 Crystal structure of the N-terminal kinase domain of MSK1 (1.8 Å resolution) reveals a unique inactive conformation in which the ATP-binding site is blocked by the nucleotide binding loop, stabilized by a novel three-stranded β-sheet formed by the N terminus, what would be the αB helix, and the activation loop. X-ray crystallography Structure High 15274926
2004 MSK1 is required for TGF-β-induced transcriptional responses via the p38α/MSK1 pathway; dominant-interfering MSK1 mutants block Smad3 binding to the co-activator p300 in response to TGF-β, positioning MSK1 as a chromatin-remodeling node integrating Smad and p38 MAPK signaling. Dominant-interfering MSK1 mutants, p38 pharmacological inhibition, Co-IP (Smad3–p300 interaction), transcriptional reporter assays The Journal of biological chemistry Medium 15133024
2005 MSK1 activity is regulated by a multi-site phosphorylation cascade: ERK1/2 or p38 phosphorylate Thr581 and Ser360, activating the C-terminal kinase domain, which autophosphorylates Ser212 (N-terminal T-loop) and Ser376 (hydrophobic motif), both essential for N-terminal kinase domain activity. Ser381 autophosphorylation also supports activity. Activation does not require PDK1, distinguishing MSK1 from RSKs. In vitro kinase assay, alanine-scanning mutagenesis of phosphorylation sites, mass spectrometry, activity assays in cells The Biochemical journal High 15568999
2005 In the suprachiasmatic nucleus (SCN), photic stimulation activates MSK1 via a PACAP-ERK/MAPK-dependent mechanism; MSK1 Ser360 phosphorylation (required for kinase activation) is induced by light during the subjective night; activated ERK and MSK1 co-localize in SCN cell nuclei; MSK1 couples to mPeriod1 clock gene expression via a CREB-dependent mechanism. In vivo phospho-specific immunohistochemistry, MEK inhibitor (U0126) infusion, PACAP receptor antagonist, luciferase reporter assay The Journal of neuroscience Medium 15930378
2007 MSK1 has a novel phosphorylation site at Thr700 phosphorylated by upstream kinases ERK1/2 and p38α; mutation of Thr700 increases basal MSK1 activity but dramatically reduces Thr581 phosphorylation (essential for activity), consistent with a mechanism whereby Thr700 phosphorylation relieves inhibition by a C-terminal autoinhibitory helix and induces a conformational shift that protects Thr581 from dephosphorylation. Precursor ion scanning mass spectrometry, site-directed mutagenesis, in vitro kinase assays, phospho-specific immunoblotting The Biochemical journal High 17117922
2007 MSK1 is the major kinase for Ca2+-ionophore-induced Bad phosphorylation in PC12 cells and cortical neurons; siRNA knockdown of MSK1 reduces Bad phosphorylation; in contrast, knockdown of RSK2 potentiates Bad phosphorylation and elevates ERK phosphorylation, implicating RSK2 in negative-feedback regulation of ERK. siRNA knockdown of MSK1 or RSK2, phospho-specific immunoblotting in PC12 cells and primary cortical neurons Journal of neurochemistry Medium 17663748
2007 Ca2+-stimulated adenylyl cyclase activity is absolutely required for activation of PKA, MAPK, MSK1, and CREB in hippocampal CA1 pyramidal neurons following contextual fear conditioning; MSK1 is identified as the major CREB kinase activated during training for contextual memory. Fear-conditioning behavioral paradigm, adenylyl cyclase knockout mice, phospho-specific immunohistochemistry Neuron Medium 17196532
2008 MSK1 and MSK2 are required to limit pro-inflammatory cytokine production in macrophages stimulated with LPS by inducing transcription of the MAPK phosphatase DUSP1 and anti-inflammatory cytokine IL-10; MSK1/2 deficiency prevents binding of phosphorylated CREB and ATF1 to the DUSP1 and IL-10 gene promoters; MSK1/2 double-knockout mice are hypersensitive to LPS-induced endotoxic shock. MSK1/MSK2 double-knockout mice and macrophages, cytokine ELISA, chromatin immunoprecipitation (ChIP), endotoxic shock model, contact eczema model Nature immunology High 18690222
2008 Glucocorticoid receptor (GR), upon ligand activation, triggers redistribution of nuclear MSK1 to the cytoplasm via a CRM1-dependent nuclear export mechanism, mediated by a direct protein-protein interaction between liganded GR and activated MSK1; this altered subcellular distribution reduces MSK1 recruitment to inflammatory gene promoters, thereby inhibiting NF-κB p65 transactivation and histone H3 phosphorylation. Co-immunoprecipitation (GR–MSK1 interaction), CRM1 inhibitor (leptomycin B), chromatin immunoprecipitation, subcellular fractionation The EMBO journal High 18511904
2008 MSK1 phosphorylates RARα at Ser369 in the ligand-binding domain in a p38MAPK-dependent manner; this phosphorylation allows TFIIH binding and subsequent cdk7/cyclin H-mediated phosphorylation of the RARα N-terminal domain at Ser77; MSK1 also phosphorylates histone H3 at Ser10 in this context; the entire p38MAPK/MSK1-initiated cascade controls recruitment of RARα/TFIIH to response elements and target gene activation. In vitro kinase assay, site-directed mutagenesis of RARα phosphorylation sites, chromatin immunoprecipitation, pharmacological inhibition of p38MAPK/MSK1 The EMBO journal High 19078967
2009 MSK1 mediates NF-κB p65 Ser276 phosphorylation induced by p38/ERK MAPK pathways; MSK1 knockdown by siRNA or kinase-dead MSK1 reduces RSV-induced phospho-Ser276 RelA formation; a RelA Ser276Ala mutation abolishes RSV-induced NF-κB-dependent gene expression, establishing that ROS → MSK1 → RelA-Ser276 phosphorylation is a distinct pathway from the pathway controlling RelA cytoplasmic release. siRNA knockdown of MSK1, pharmacological inhibition (H89), expression of RelA Ser276Ala mutant in RelA-/- MEFs, phospho-specific immunoblotting Journal of virology High 19706715
2009 MSK1 is recruited to inflammatory gene promoters as part of a multi-protein complex containing 14-3-3 phospho-serine adaptor proteins and BRG1 (ATPase subunit of SWI/SNF); MSK1 is recruited by transcription factors such as Elk-1 or NF-κB; following MSK1-mediated H3 Ser10/Ser28 phosphorylation, BRG1 associates with promoters via 14-3-3 scaffolds and SWI/SNF remodels nucleosomes to enable transcription factor binding and transcription onset. Sequential co-immunoprecipitation, sequential chromatin immunoprecipitation (ChIP), MSK1 knockdown cells Nucleic acids research Medium 20129940
2010 MSK1 phosphorylates histone H3 at the c-fos promoter in a CREB-dependent manner; in a reconstituted cell-free system, activators (SRF, Elk-1, CREB, ATF1) bound to their cognate sites recruit MSK1 to phosphorylate H3 Ser10 within chromatin; CREB plays the predominant role, and Ser133 phosphorylation of CREB is essential; the MSK1 N-terminal inhibition domain is critical for chromatin-embedded H3 phosphorylation. Cell-free chromatin reconstitution assay, MSK1 mutagenesis (N-terminal inhibition domain), phospho-specific analysis The Journal of biological chemistry High 20089855
2010 MSK1 is required for induction of the miR-212/132 cluster in primary cortical neurons in response to BDNF; regulation occurs via the ERK1/2 pathway through both MSK-dependent and MSK-independent mechanisms, as shown using MSK1/2 knockout mice and specific inhibitors. MSK1/2 knockout mice, specific kinase inhibitors, deep sequencing, promoter analysis The Biochemical journal Medium 20307261
2011 An acute psychological stressor induces ERK1/2 phosphorylation in dentate gyrus granule neurons within 15 min, leading to nuclear activation of MSK1 and Elk-1; MSK1 and Elk-1 then evoke H3 Ser10 phosphorylation and H3 Lys14 acetylation, resulting in c-Fos and Egr-1 induction; pERK1/2-mediated activation of MSK1 and Elk-1 requires a direct protein-protein interaction between pERK1/2 and activated glucocorticoid receptors. In vivo mouse stress model, co-immunoprecipitation (pERK1/2–GR interaction), phospho-specific immunohistochemistry, ChIP Proceedings of the National Academy of Sciences of the United States of America Medium 21808001
2012 MSK1 is necessary for homeostatic synaptic scaling and experience-dependent synaptic plasticity; neurons from MSK1 kinase-dead knock-in mice fail to show scaling in response to activity deprivation; MSK1 forms part of a BDNF/MAPK-dependent signaling cascade that regulates cell-surface GluA1 expression via induction of Arc/Arg3.1. MSK1 kinase-dead knock-in mice, electrophysiology (synaptic scaling), rescue by WT MSK1 re-expression, GluA1 surface expression assay The Journal of neuroscience High 22993422
2013 Downregulation of RAS-MAPK-MSK1 pathway components decreases ATXN1 levels and suppresses neurodegeneration in Drosophila and mice; pharmacological inhibition of pathway components also decreases ATXN1 levels, identifying MSK1 as a node in a genetic network that controls the abundance of the SCA1-causing protein. Parallel cell-based and Drosophila genetic screens, mouse SCA1 model, pharmacological inhibitors, protein level measurement Nature High 23719381
2016 MSK1 (Msk1/RPS6KA5) physically interacts with the KMT2A/MLL1 lysine methyltransferase complex by co-immunoprecipitation; the majority of genes regulated by KMT2A/MLL1 knockdown respond comparably to MSK1 knockdown; KMT2A/MLL1 is required for genomic targeting of MSK1 (but not vice versa); MSK1 supports H3K4 methylation by KMT2A/MLL1 by catalyzing H3S10 and H3S28 phosphorylation. Co-immunoprecipitation (native and FLAG-tagged), siRNA knockdown, ChIP for H3K4me and H3S10ph at target loci Epigenetics & chromatin Medium 27895715
2016 MSK1 phosphorylates β-catenin and regulates its nuclear translocation and transcriptional activity in glioblastoma cells; MSK1 is induced after PI3K/mTOR inhibitor treatment; depletion of MSK1 attenuates resistance to PI3K/mTOR inhibitors; MSK1 inhibition plus PI3K/mTOR inhibition synergizes to extend survival in an intracranial animal model. shRNA-mediated MSK1 depletion, phospho-specific immunoblotting of β-catenin Ser552, nuclear fractionation, intracranial mouse model Molecular cancer therapeutics Medium 27196759
2018 MSK1 controls expression of luminal differentiation genes GATA3 and FOXA1 by modulating their promoter chromatin status (H3 phosphorylation); MSK1 downregulation impairs breast cancer cell differentiation, increasing bone homing and growth capacities; in vivo genome-wide shRNA screen identified MSK1 as a regulator of metastatic dormancy. In vivo genome-wide shRNA screen, MSK1 knockdown/overexpression, ChIP for histone modifications at GATA3/FOXA1 promoters, in vivo bone metastasis model Nature cell biology High 29358704
2019 MSK1 is a downstream target of both early and late ERK activation following DNA damage; early ERK→MSK1 activation (mediated by EGFR) promotes cell survival and DNA repair; late ERK→MSK1 activation (requiring PKCδ) drives apoptosis via a nuclear PKCδ→ERK→MSK1 signaling module; both ERK and MSK1 activations are required for apoptosis in the late phase. shRNA-mediated depletion of MSK1, PKCδ, and EGFR; pharmacological inhibitors (MEK/ERK, EGFR); phospho-specific immunoblotting; in vivo irradiation model The Journal of biological chemistry Medium 30679314
2020 STAT3 aberrantly transactivates MSK1 gene expression, and MSK1 in turn phosphorylates H3S10 and STAT3 itself; STAT3 forms a functional complex with MSK1 at the NFATc2 promoter to promote its transcription in an H3S10 phosphorylation-dependent manner, creating a positive STAT3-MSK1 feedback loop in gastric carcinogenesis. Co-immunoprecipitation (STAT3–MSK1 complex), ChIP at NFATc2 promoter, MSK1 knockdown/overexpression, xenograft tumor model, phospho-specific immunoblotting Oncogenesis Medium 32041943
2023 MSK1 is transcriptionally activated by HOXC6 in pancreatic ductal adenocarcinoma; MSK1 phosphorylates DDX17 to suppress apoptosis; pharmacological inhibition of MSK1 combined with mTOR inhibition potently suppresses PDAC tumor growth and metastasis in mouse models. ChIP (HOXC6 at MSK1 promoter), siRNA/shRNA knockdown, phospho-specific identification of DDX17 as MSK1 substrate, in vivo PDAC mouse models, pharmacological inhibition Cell reports. Medicine Medium 37951219
2017 MSK1 regulates BDNF-induced Arc/Arg3.1 expression via phosphorylation of histone H3 at the Arc/Arg3.1 promoter, acting downstream of ERK1/2; however, CREB Ser133 phosphorylation by MSK1 is not required for BDNF-induced Arc/Arg3.1 transcription, as a Ser133Ala CREB knock-in had no effect on induction. MSK1 kinase-dead knock-in mice, ChIP for H3 phosphorylation at Arc promoter, CREB Ser133Ala knock-in mice, pharmacological inhibitors FEBS open bio Medium 28593137
2009 Glucocorticoid-activated GR physically interacts with activated MSK1 (Co-IP) and drives CRM1-dependent nuclear export of MSK1; this redistribution prevents recruitment of activated MSK1 to inflammatory gene promoters (ChIP), resulting in reduced NF-κB p65 transactivation and histone H3 phosphorylation. Co-immunoprecipitation, CRM1 inhibitor (leptomycin B), ChIP, subcellular fractionation The EMBO journal High 18511904
2005 In NIH 3T3 cells, cAMP/forskolin activates p38 in a PKA-dependent fashion; p38 then activates CREB-mediated transcription via MSK1, as shown using dominant-negative MSK1 mutants and H89, but not dominant-negative MSK2 or MAPKAPK2. Dominant-negative mutant transfection, pharmacological inhibitors, reporter gene assays Cellular signalling Medium 16125054
2009 MSK1 is required for TLR-mediated induction of IL-1ra mRNA and protein from both proximal and distal promoters in macrophages; this occurs via p38 and ERK1/2 MAPK cascades, through both IL-10-dependent and IL-10-independent mechanisms; MSK1/2 knockout mice show decreased IL-1ra production after LPS injection. MSK1/2 knockout macrophages and mice, RT-PCR/ELISA for IL-1ra, promoter-reporter assays The Biochemical journal Medium 19922413
2005 MSK1 is confined to the nucleus of all expressing cell types in mouse brain (neurons and astroglia), in contrast to RSK1 which localizes to the Golgi apparatus; MSK1 is expressed at highest levels in striatal and olfactory tubercle neurons and in cerebellar Purkinje cells, with lower expression in a subset of astroglia. Immunohistochemistry on adult mouse brain sections Brain research. Molecular brain research Medium 15893597

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1998 Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. The EMBO journal 845 9687510
2003 Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). The EMBO journal 648 12628924
2003 MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. The EMBO journal 411 12773393
1999 The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. The EMBO journal 376 10469656
2002 MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Molecular and cellular biology 375 11909979
2005 The cAMP signalling pathway activates CREB through PKA, p38 and MSK1 in NIH 3T3 cells. Cellular signalling 276 16125054
2008 The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nature immunology 271 18690222
2003 Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. The Journal of biological chemistry 230 12690113
2006 ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts. Cellular signalling 225 16806820
2010 Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins. The Biochemical journal 181 20307261
2007 Ca2+ -stimulated adenylyl cyclases regulate ERK-dependent activation of MSK1 during fear conditioning. Neuron 170 17196532
2012 Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. The Journal of biological chemistry 168 22733812
2010 MiR-148a attenuates paclitaxel resistance of hormone-refractory, drug-resistant prostate cancer PC3 cells by regulating MSK1 expression. The Journal of biological chemistry 166 20406806
2000 MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells. FEBS letters 162 11018520
2005 MSK1 activity is controlled by multiple phosphorylation sites. The Biochemical journal 141 15568999
2010 Promoter chromatin remodeling of immediate-early genes is mediated through H3 phosphorylation at either serine 28 or 10 by the MSK1 multi-protein complex. Nucleic acids research 125 20129940
2011 Long-lasting behavioral responses to stress involve a direct interaction of glucocorticoid receptors with ERK1/2-MSK1-Elk-1 signaling. Proceedings of the National Academy of Sciences of the United States of America 124 21808001
2009 Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation. PloS one 121 19197368
2013 RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature 118 23719381
2012 Breast tumor-associated osteoblast-derived CXCL5 increases cancer progression by ERK/MSK1/Elk-1/snail signaling pathway. Oncogene 112 23045282
2018 MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer. Nature cell biology 107 29358704
2009 Role of the ERK/MSK1 signalling pathway in chromatin remodelling and brain responses to drugs of abuse. Journal of neurochemistry 107 19183268
2006 Involvement of JNKs and p38-MAPK/MSK1 pathways in H2O2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells. Cellular signalling 100 16531007
2009 Respiratory syncytial virus infection induces a reactive oxygen species-MSK1-phospho-Ser-276 RelA pathway required for cytokine expression. Journal of virology 93 19706715
2010 Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway. International journal of oncology 91 20198339
2003 Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). Oncogene 90 12569367
2008 A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters. The EMBO journal 87 19078967
2002 Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation. The Journal of biological chemistry 84 11983683
2013 Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers. PloS one 81 23533666
2008 Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition. The EMBO journal 75 18511904
2023 Exosomal miR-155-5p drives widespread macrophage M1 polarization in hypervirulent Klebsiella pneumoniae-induced acute lung injury via the MSK1/p38-MAPK axis. Cellular & molecular biology letters 73 37953267
2007 p38 MAPK and MSK1 mediate caspase-8 activation in manganese-induced mitochondria-dependent cell death. Cell death and differentiation 73 17585337
2001 Ultraviolet B-induced phosphorylation of histone H3 at serine 28 is mediated by MSK1. The Journal of biological chemistry 70 11441012
2001 MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells. The Journal of biological chemistry 66 11553624
2005 Light stimulates MSK1 activation in the suprachiasmatic nucleus via a PACAP-ERK/MAP kinase-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience 65 15930378
2012 MSK1 regulates homeostatic and experience-dependent synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience 64 22993422
2002 Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation. The Journal of biological chemistry 64 11777913
2004 Tumor necrosis factor activates CRE-binding protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells. American journal of physiology. Cell physiology 62 14761884
2007 Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect. The Journal of investigative dermatology 61 17495961
2004 Phenylephrine induces activation of CREB in adult rat cardiac myocytes through MSK1 and PKA signaling pathways. Journal of molecular and cellular cardiology 60 15522277
2003 Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. Experimental hematology 59 12763138
2008 NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway. The Journal of biological chemistry 56 18424438
2003 MSK1 and MSK2 mediate mitogen- and stress-induced phosphorylation of histone H3: a controversy resolved. Science's STKE : signal transduction knowledge environment 54 12915720
2014 Kaempferol targets RSK2 and MSK1 to suppress UV radiation-induced skin cancer. Cancer prevention research (Philadelphia, Pa.) 52 24994661
2012 Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-κB-dependent genes. PloS one 51 22312446
2003 The kinase MSK1 is required for induction of c-fos by lysophosphatidic acid in mouse embryonic stem cells. BMC molecular biology 50 12769834
2012 Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner. Experimental dermatology 49 22626465
2007 Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS. The Biochemical journal 46 17117922
2013 The p38-MSK1 signaling cascade influences cytokine production through CREB and C/EBP factors in human neutrophils. Journal of immunology (Baltimore, Md. : 1950) 45 24038085
1999 Cloning and characterization of RLPK, a novel RSK-related protein kinase. The Journal of biological chemistry 45 9873047
2015 Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2. Scientific reports 43 26611568
2011 Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling. PloS one 43 22140508
2010 MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages. The Biochemical journal 41 19922413
2004 The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein. Structure (London, England : 1993) 41 15274926
2004 Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1. Carcinogenesis 39 14963018
2013 The roles of p38 MAPK/MSK1 signaling pathway in the neuroprotection of hypoxic postconditioning against transient global cerebral ischemia in adult rats. Molecular neurobiology 37 24352802
2011 Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 37 21340650
2003 Mitogen and stress response kinase-1 (MSK1) mediates excitotoxic induced death of hippocampal neurones. Journal of neurochemistry 37 12807421
2013 MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop. Molecular and cellular biology 35 23382072
2006 The kinases MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylation. The Journal of biological chemistry 35 16517600
2021 Hippocampal MSK1 regulates the behavioral and biological responses of mice to chronic social defeat stress: Involving of the BDNF-CREB signaling and neurogenesis. Biochemical pharmacology 34 34774532
2015 UVB Stimulates the Expression of Endothelin B Receptor in Human Melanocytes via a Sequential Activation of the p38/MSK1/CREB/MITF Pathway Which Can Be Interrupted by a French Maritime Pine Bark Extract through a Direct Inactivation of MSK1. PloS one 34 26030901
2004 Evidence for a role of MSK1 in transforming growth factor-beta-mediated responses through p38alpha and Smad signaling pathways. The Journal of biological chemistry 34 15133024
2011 Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model. Cancer investigation 33 21314333
2009 IL-17F-induced IL-11 release in bronchial epithelial cells via MSK1-CREB pathway. American journal of physiology. Lung cellular and molecular physiology 32 19251839
2020 STAT3 activates MSK1-mediated histone H3 phosphorylation to promote NFAT signaling in gastric carcinogenesis. Oncogenesis 31 32041943
2015 Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR. Virology 30 25980739
2010 Role of MSK1 in the malignant phenotype of Ras-transformed mouse fibroblasts. The Journal of biological chemistry 29 21071437
2020 RLP/K enrichment sequencing; a novel method to identify receptor-like protein (RLP) and receptor-like kinase (RLK) genes. The New phytologist 28 32285454
2016 Peptide IDR-1002 Inhibits NF-κB Nuclear Translocation by Inhibition of IκBα Degradation and Activates p38/ERK1/2-MSK1-Dependent CREB Phosphorylation in Macrophages Stimulated with Lipopolysaccharide. Frontiers in immunology 28 27933067
2012 MSK1 regulates environmental enrichment-induced hippocampal plasticity and cognitive enhancement. Learning & memory (Cold Spring Harbor, N.Y.) 28 23077336
2005 Differential localization of MAPK-activated protein kinases RSK1 and MSK1 in mouse brain. Brain research. Molecular brain research 27 15893597
2019 Role of MSK1 in the Induction of NF-κB by the Chemokine CX3CL1 in Microglial Cells. Cellular and molecular neurobiology 26 30830503
2016 MSK1-Mediated β-Catenin Phosphorylation Confers Resistance to PI3K/mTOR Inhibitors in Glioblastoma. Molecular cancer therapeutics 26 27196759
2015 Screening of the Human Kinome Identifies MSK1/2-CREB1 as an Essential Pathway Mediating Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication during Primary Infection. Journal of virology 26 26109721
2010 cAMP-response element-binding protein (CREB) controls MSK1-mediated phosphorylation of histone H3 at the c-fos promoter in vitro. The Journal of biological chemistry 26 20089855
2016 Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes. Epigenetics & chromatin 25 27895715
2010 TGFbeta activates mitogen- and stress-activated protein kinase-1 (MSK1) to attenuate cell death. The Journal of biological chemistry 25 21106525
2016 Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways. Molecular and cellular biology 24 27795299
2015 The UVB-Stimulated Expression of Transglutaminase 1 Is Mediated Predominantly via the NFκB Signaling Pathway: New Evidence of Its Significant Attenuation through the Specific Interruption of the p38/MSK1/NFκBp65 Ser276 Axis. PloS one 24 26305102
2014 Lanthanum chloride impairs spatial memory through ERK/MSK1 signaling pathway of hippocampus in rats. Neurochemical research 24 25316495
2017 The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory. eNeuro 23 28275711
2014 TNF induces the expression of the sialyltransferase ST3Gal IV in human bronchial mucosa via MSK1/2 protein kinases and increases FliD/sialyl-Lewis(x)-mediated adhesion of Pseudomonas aeruginosa. The Biochemical journal 23 24099577
2019 EGF receptor and PKCδ kinase activate DNA damage-induced pro-survival and pro-apoptotic signaling via biphasic activation of ERK and MSK1 kinases. The Journal of biological chemistry 22 30679314
2018 The stem cell factor-stimulated melanogenesis in human melanocytes can be abrogated by interrupting the phosphorylation of MSK1: evidence for involvement of the p38/MSK1/CREB/MITF axis. Archives of dermatological research 22 29362867
2013 Angiopoietin2 enhances doxorubin resistance in HepG2 cells by upregulating survivin and Ref-1 via MSK1 activation. Cancer letters 20 23643942
2019 Inhibition of MSK1 Promotes Inflammation and Apoptosis and Inhibits Functional Recovery After Spinal Cord Injury. Journal of molecular neuroscience : MN 19 30919247
2017 ERK1 is dispensable for mouse pancreatic beta cell function but is necessary for glucose-induced full activation of MSK1 and CREB. Diabetologia 19 28721437
2012 Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade. The Journal of biological chemistry 19 23038261
2009 Differential regulation of mitogen- and stress-activated protein kinase-1 and -2 (MSK1 and MSK2) by CK2 following UV radiation. The Journal of biological chemistry 19 19933278
2007 Contrasting roles of neuronal Msk1 and Rsk2 in Bad phosphorylation and feedback regulation of Erk signalling. Journal of neurochemistry 19 17663748
2023 HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B. Cell reports. Medicine 18 37951219
2017 MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins. FEBS open bio 17 28593137
2011 Thrombin induces inducible nitric oxide synthase expression via the MAPK, MSK1, and NF-κB signaling pathways in alveolar macrophages. European journal of pharmacology 17 22004609
2024 Interruption of p38MAPK-MSK1-CREB-MITF-M pathway to prevent hyperpigmentation in the skin. International journal of biological sciences 16 38481807
2023 8-Oxoguanine DNA glycosylase 1 selectively modulates ROS-responsive NF-κB targets through recruitment of MSK1 and phosphorylation of RelA/p65 at Ser276. The Journal of biological chemistry 16 37778730
2020 Experience Recruits MSK1 to Expand the Dynamic Range of Synapses and Enhance Cognition. The Journal of neuroscience : the official journal of the Society for Neuroscience 15 32376781
2020 Astroglia-Derived BDNF and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity. Brain sciences 15 32708382
2018 High nuclear MSK1 is associated with longer survival in breast cancer patients. Journal of cancer research and clinical oncology 15 29327245
2008 Differential roles of MAPKs and MSK1 signalling pathways in the regulation of c-Jun during phenylephrine-induced cardiac myocyte hypertrophy. Molecular and cellular biochemistry 15 19002563

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