Affinage

RNF6

E3 ubiquitin-protein ligase RNF6 · UniProt Q9Y252

Length
685 aa
Mass
78.1 kDa
Annotated
2026-06-10
38 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RNF6 is a RING-domain E3 ubiquitin ligase that controls the abundance of diverse regulatory proteins to govern cytoskeletal dynamics, nuclear receptor signaling, and proliferative control, and additionally acts as a sequence-specific nuclear transcriptional regulator (PMID:16204183, PMID:19345326, PMID:11971979). Its founding activity was defined in neurons, where it binds and polyubiquitinates LIMK1 to drive its proteasomal degradation and thereby tune growth-cone actin dynamics and axon outgrowth (PMID:16204183). Across cancer contexts RNF6 acts predominantly as an oncogenic ligase by destroying negative regulators of growth and survival pathways: it ubiquitinates and degrades the Wnt/β-catenin repressor TLE3 (PMID:29374067), the EMT repressor FoxA1 (PMID:30496760), the STAT3-inhibitory phosphatase SHP-1 (PMID:30323630), the Hippo kinase MST1 to elevate YAP signaling (PMID:34970341), and the CDK inhibitor p27/Kip1 to promote CDK2/Cyclin E activity and G1/S progression (PMID:35456636, PMID:39938447). It directs K48-linked polyubiquitination and degradation of cyclin D2 via substrate residue Thr280 to enforce G1 arrest in lung adenocarcinoma (PMID:39918413) and degrades NME4 to activate JNK/c-JUN signaling (PMID:41616518). Beyond degradative ubiquitination, RNF6 can stabilize substrates: it attaches K63-linked chains to the glucocorticoid receptor, increasing GR protein levels and pro-survival transcription (PMID:31645658). RNF6 also ubiquitinates substrates that reprogram autophagy and barrier integrity, including QKI in macrophages and Sqstm1 at K314 in endothelial cells (PMID:36088389, PMID:40231770). In the nucleus it binds defined promoter elements—a GGGGC repeat in the Inha promoter and the CCNA1/CREBBP promoters—to directly regulate transcription (PMID:11971979, PMID:37904524). RNF6 itself is regulated by RING-dependent K48-linked auto-ubiquitination that is reversed by the deubiquitinase USP7, and its transcription is activated by PBX1/PREP1 (PMID:35926709, PMID:26971355).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2002 Medium

    Established RNF6 as a nuclear factor capable of direct promoter binding and transcriptional control, an activity distinct from its later-defined ligase function.

    Evidence Expression screening, reporter assays, and immunofluorescence co-localization with PML/Daxx in Sertoli cells

    PMID:11971979

    Open questions at the time
    • Did not connect transcriptional activity to ubiquitin ligase function
    • Sequence-specificity of the GGGGC-motif binding not structurally defined
  2. 2005 High

    Defined RNF6's first molecular substrate, showing it is an E3 ligase that degrades LIMK1 to control axonal actin dynamics.

    Evidence Co-IP, in vitro ubiquitination, RNAi with LIMK1 rescue in primary hippocampal neurons

    PMID:16204183

    Open questions at the time
    • Ubiquitin chain linkage type not specified
    • Did not address RNF6 substrate selectivity beyond LIMK1
  3. 2009 High

    Linked RNF6 to nuclear receptor signaling, showing it ubiquitinates AR and selectively reprograms AR target-gene transcription rather than simply degrading the receptor.

    Evidence Proteomic Co-IP, AR ubiquitination-site mutagenesis, ChIP, and RNAi transcriptional readout

    PMID:19345326

    Open questions at the time
    • Mechanism by which AR ubiquitination alters coactivator recruitment not fully resolved
    • Linkage type and fate of ubiquitinated AR not detailed
  4. 2016 Medium

    Identified upstream transcriptional control of RNF6, defining how its expression is set rather than how it acts.

    Evidence RNF6 promoter truncation/PRE-mutation luciferase reporters and ChIP for PBX1/PREP1

    PMID:26971355

    Open questions at the time
    • Tissue contexts of PBX1-driven RNF6 expression not broadly mapped
    • Does not address post-translational regulation of RNF6
  5. 2018 High

    Established RNF6 as an oncogenic ligase across multiple cancers by degrading distinct tumor-suppressive substrates feeding Wnt, EMT, and STAT3 pathways.

    Evidence Co-IP, ubiquitination assays, and substrate-rescue/in vivo models for TLE3, FoxA1, and SHP-1

    PMID:29374067 PMID:30323630 PMID:30496760

    Open questions at the time
    • Whether one ligase engages all substrates simultaneously or context-specifically is unclear
    • Ubiquitination linkage detail varies between substrates
  6. 2019 Medium

    Revealed a non-degradative mode, showing RNF6 stabilizes GR via K63-linked ubiquitination to drive pro-survival transcription and drug resistance.

    Evidence Co-IP, K63-linkage-specific ubiquitination assay, luciferase reporter in multiple myeloma cells

    PMID:31645658

    Open questions at the time
    • Structural basis for K48-versus-K63 substrate-dependent chain choice unknown
    • Single-lab finding
  7. 2021 Low

    Extended RNF6 substrate range to Hippo signaling via MST1 degradation, though with limited mechanistic depth.

    Evidence Co-IP and ubiquitination assay with YAP and metastasis readouts in breast cancer cells

    PMID:34970341

    Open questions at the time
    • Single lab, limited mechanistic depth; chain linkage and direct ubiquitination sites not defined
    • Indirect Wnt/GSK3β effects reported separately remain non-direct
  8. 2022 High

    Resolved how RNF6 is itself controlled, demonstrating RING-dependent K48 auto-ubiquitination opposed by the deubiquitinase USP7.

    Evidence RING deletion and C632S/C635S active-site mutagenesis, MS identification of USP7, in vitro ubiquitination reconstitution

    PMID:35926709

    Open questions at the time
    • Physiological signals controlling the RNF6/USP7 balance not mapped
    • Whether USP7 also edits RNF6 substrate chains untested
  9. 2022 Medium

    Connected RNF6 to direct cell-cycle control via p27/Kip1 degradation through a defined KIL domain interaction.

    Evidence Co-IP with domain mapping, ubiquitination assay, shRNA with G1-arrest readout in prostate cancer cells

    PMID:35456636

    Open questions at the time
    • Generality of KIL-domain-mediated substrate recognition unknown
    • Single lab
  10. 2023 Medium

    Reaffirmed RNF6's direct transcription-factor activity by mapping genome-wide promoter binding to CCNA1 and CREBBP.

    Evidence ChIP-seq/ChIP-PCR with rescue and luciferase validation in gastric cancer cells

    PMID:37904524

    Open questions at the time
    • DNA-binding mode of a RING ligase acting as a transcription factor not structurally explained
    • Relationship between ligase and transcriptional roles unresolved
  11. 2025 High

    Defined substrate-residue-level control of cyclin D2 and broadened RNF6's degradative targets to NME4 and to SKP2-coupled p27 regulation.

    Evidence MS substrate ID, RING-deletion and substrate-site (CCND2 Thr280) mutagenesis, K48 linkage assays, SKP2 promoter reporter, in vivo xenografts

    PMID:39918413 PMID:39938447 PMID:41616518

    Open questions at the time
    • Context determining whether RNF6 arrests (CCND2) or drives (p27/SKP2) the cycle is unclear
    • Dual direct-and-transcriptional control of p27 not fully integrated
  12. 2025 Medium

    Implicated RNF6 in autophagy and barrier biology via site-specific Sqstm1 ubiquitination downstream of CXCL13.

    Evidence K314 site-specific ubiquitination assay, Co-IP, in vivo EAE barrier-permeability model

    PMID:40231770

    Open questions at the time
    • Whether Sqstm1 K314 ubiquitination is degradative or signaling-type not stated
    • Single disease model
  13. 2026 Medium

    Extended RNF6 substrates to deubiquitinase regulation (OTULIN) and host-pathogen biology (ZIKV NS5), revealing innate-immune and EMT-modulatory roles.

    Evidence MS-based substrate ID with stability assays for OTULIN; CRISPR screen and Co-IP for ZIKV NS5 interaction

    PMID:41902231 PMID:42055142

    Open questions at the time
    • Whether RNF6 ubiquitinates NS5 or acts non-catalytically as proviral factor unresolved
    • OTULIN chain linkage and broader linear-ubiquitin consequences untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RNF6 selects among its many substrates and chooses degradative (K48) versus stabilizing (K63) chain linkages, and how its E3-ligase and direct transcription-factor activities are coordinated within the same protein, remains unresolved.
  • No structural model of substrate recognition or chain-type determination
  • No unified account linking nuclear DNA-binding and cytoplasmic ligase functions
  • Most substrate findings are single-lab

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 6 GO:0140096 catalytic activity, acting on a protein 4 GO:0003677 DNA binding 2 GO:0016874 ligase activity 2 GO:0140110 transcription regulator activity 2
Localization
GO:0005634 nucleus 2
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-392499 Metabolism of proteins 4 R-HSA-1640170 Cell Cycle 3 R-HSA-74160 Gene expression (Transcription) 2 R-HSA-9612973 Autophagy 2
Partners
ARFOXA1GRLIMK1MST1SHP-1TLE3USP7

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 RNF6 binds to, polyubiquitinates, and targets LIMK1 for proteasomal degradation in growth cones of primary hippocampal neurons. RNAi-mediated knockdown of Rnf6 alters axon outgrowth, and this phenotype can be rescued by modulating LIMK1 expression, placing RNF6 upstream of LIMK1 in the control of axonal growth cone actin dynamics. Co-IP/pulldown, in vitro ubiquitination assay, RNAi knockdown with phenotypic rescue, primary hippocampal neuron cultures Genes & development High 16204183
2009 RNF6 is an E3 ubiquitin ligase that associates with the androgen receptor (AR), induces AR ubiquitination, and promotes AR transcriptional activity. Knockdown of RNF6 or mutation of RNF6-induced ubiquitination acceptor sites on AR selectively alters expression of a subset of AR target genes and diminishes recruitment of AR and its coactivators to androgen-responsive elements. Proteomic screen (Co-IP), ubiquitination assays, site-directed mutagenesis of AR ubiquitination acceptor sites, ChIP, RNAi knockdown with transcriptional readout Cancer cell High 19345326
2002 RNF6 localizes to punctate nuclear bodies together with PML and Daxx proteins in mouse Sertoli cells, and its re-expression in a Sertoli tumor cell line (where both Inha and Rnf6 are reduced) restores Inha expression and reverts cells to normal growth control, identifying RNF6 as a transcriptional regulator of the Inha promoter through binding of a GGGGC repeat motif. Expression screening, transient and stable transfection with reporter assays, co-localization by immunofluorescence, cell growth assays Molecular and cellular biology Medium 11971979
2018 RNF6 binds and ubiquitylates TLE3, a transcriptional repressor of the β-catenin/TCF4 complex, leading to TLE3 proteasomal degradation. RNF6-mediated TLE3 loss releases β-catenin to TCF4/LEF, activating Wnt/β-catenin signaling and promoting colorectal cancer cell growth and metastasis. Co-IP, ubiquitination assay, rescue experiments with TLE3 re-expression, in vivo tumor/metastasis models Cancer research High 29374067
2018 RNF6 directly binds and ubiquitylates FoxA1, a transcriptional repressor of EMT, leading to its degradation; the oncogenic effects of RNF6 in hepatocellular carcinoma are partially dependent on FoxA1 degradation. Co-IP, ubiquitination assay, RNF6 knockdown with phenotypic rescue by FoxA1, in vivo metastasis models Experimental cell research Medium 30496760
2018 RNF6 regulates STAT3 signaling in gastric cancer by inducing polyubiquitination and degradation of the phosphatase SHP-1, thereby relieving SHP-1-mediated inhibition of STAT3 phosphorylation and promoting expression of STAT3 target genes MCL1 and XIAP. Immunoprecipitation/ubiquitination assay, luciferase reporter assay, Western blot, RNF6 knockdown/overexpression OncoTargets and therapy Medium 30323630
2019 RNF6 interacts with the glucocorticoid receptor (GR) and induces K63-linked polyubiquitination of GR, which stabilizes GR protein (rather than degrading it) and promotes GR transcriptional activity, leading to increased expression of pro-survival genes Bcl-xL and Mcl-1 and resistance to dexamethasone in multiple myeloma cells. Co-IP, ubiquitination assay specifying K63 linkage, luciferase reporter assay, RNF6 overexpression/knockdown Acta pharmacologica Sinica Medium 31645658
2022 RNF6 undergoes auto-ubiquitination (K48-linked polyubiquitination) in a manner dependent on its RING domain; deletion of the RING domain (ΔRING) or mutation of core cysteine residues (C632S/C635S) abolishes this auto-ubiquitination. USP7 was identified as a deubiquitinase of RNF6 by tandem mass spectrometry; USP7 interacts with RNF6 and removes K48-linked polyubiquitin chains, preventing RNF6 degradation. Anti-cancer drugs Nilotinib and Panobinostat induce RNF6 K48-linked auto-ubiquitination and degradation in an in vitro ubiquitination system without other E3 ligases. RING domain deletion mutagenesis, cysteine-to-serine point mutagenesis, tandem mass spectrometry identification of USP7, Co-IP, in vitro ubiquitination reconstitution assay The Journal of biological chemistry High 35926709
2022 RNF6 interacts with p27 (Kip1) via its KIL domain in a phosphorylation-independent manner, enhances ubiquitination and subsequent proteasomal degradation of p27 in the early G0/G1 phase of the cell cycle, and thereby promotes CDK2/Cyclin E complex activity, Rb phosphorylation, and cell cycle progression in prostate cancer cells. Co-IP, ubiquitination assay, shRNA knockdown with cell cycle (G1 arrest) readout, domain mapping Pharmaceutics Medium 35456636
2021 RNF6 interacts with MST1 (a kinase regulating YAP), promotes MST1 ubiquitination and degradation, and thereby upregulates YAP signaling to promote breast cancer cell metastasis. Co-IP, ubiquitination assay, RNF6 knockdown/overexpression with YAP and metastasis readouts Experimental and therapeutic medicine Low 34970341
2021 RNF6 promotes colorectal cancer invasion and migration by increasing GSK3β phosphorylation (inhibiting GSK3β activity), which in turn activates the Wnt/β-catenin pathway. RNF6 overexpression/silencing with Western blot, GSK3β inhibitor rescue, in vivo rat CRC model Pathology, research and practice Low 34352441
2022 RNF6 mediates ubiquitination and degradation of the RNA-binding protein QKI in macrophages; this RNF6-mediated QKI degradation activates PI3K-p110β-dependent autophagy and enhances phagocytic clearance of MRSA. Co-IP, iTRAQ mass spectrometry, immunoprecipitation-ubiquitination assay, QKI knockout mouse model, MRSA infection model Cell & bioscience Medium 36088389
2023 In gastric cancer cells, RNF6 localizes to the nucleus and directly binds to the promoter regions of CCNA1 and CREBBP, acting as a transcription factor to regulate their expression and promote tumor cell cycle progression and apoptosis resistance. ChIP-seq, ChIP-PCR, RNF6 overexpression/silencing with CCNA1/CREBBP rescue, luciferase assay Cell cycle (Georgetown, Tex.) Medium 37904524
2025 RNF6 physically binds cyclin D2 (CCND2) and mediates its K48-linked polyubiquitination and proteasomal degradation in lung adenocarcinoma cells. RING-domain-deleted RNF6 (ΔRING) fails to ubiquitinate CCND2. Thr280 on CCND2 is critical for its stability; T280 mutation makes CCND2 more stable and less susceptible to RNF6-mediated ubiquitination. RNF6 arrests LUAD cells in G1 by inhibiting CCND2/phospho-Rb signaling. Affinity purification/tandem MS, Co-IP, ubiquitination assay, RING domain deletion mutagenesis, Thr280 point mutation, cell cycle analysis, in vivo xenograft Molecular cancer research : MCR High 39918413
2025 RNF6 interacts with p27 and directly ubiquitinates it via E3 ligase activity, and also indirectly accelerates p27 degradation by acting as a transcription factor to activate SKP2 promoter activity and by interacting with SKP2 to stabilize its protein levels in an Akt-dependent manner, thereby driving glioblastoma cell proliferation. Co-IP, ubiquitination assay, SKP2 promoter reporter assay, Western blot, RNF6 knockdown/overexpression with cell growth readout Biochemical and biophysical research communications Medium 39938447
2025 CXCL13 enhances RNF6 expression in endothelial cells, and RNF6 facilitates ubiquitination of Sqstm1 at the K314 residue, thereby promoting autophagy and damaging blood spinal cord barrier integrity in experimental allergic encephalomyelitis. Co-IP, ubiquitination assay (K314 site-specific), Western blot, in vivo EAE model with barrier permeability readout Advanced science Medium 40231770
2026 RNF6 directly binds NME4 and facilitates its K48-linked polyubiquitination and proteasomal degradation; NME4 degradation activates the JNK/c-JUN pathway in ovarian cancer cells, promoting proliferation, invasion, and EMT. Co-IP, CHX chase assay, ubiquitination assay (K48-specific), RNF6/NME4 knockdown rescue experiments, in vivo xenograft Pathology, research and practice Medium 41616518
2026 RNF6 promotes ubiquitination and proteasomal degradation of OTULIN (a linear deubiquitinase) in bronchial epithelial cells; RNF6 knockdown stabilizes OTULIN and suppresses TGF-β1-induced partial EMT-like phenotypic changes, while OTULIN knockdown reverses the protective effect of RNF6 silencing. Co-IP/mass spectrometry (label-free proteomics), Co-IP validation, immunofluorescence co-localization, cycloheximide/MG132 stability assay, RNF6 and OTULIN knockdown rescue experiments Biochemical pharmacology Medium 42055142
2026 RNF6 interacts with the Zika virus NS5 protein and acts as a negative regulator of type I interferon and MAPK signaling pathways, functioning as a proviral host factor for ZIKV replication in brain microvascular endothelial cells; RNF6 knockout reduces ZIKV infection while overexpression enhances it. Genome-wide CRISPR/Cas9 screen, RNF6 knockout/knockdown/overexpression with viral replication readout, Co-IP for NS5 interaction, molecular docking Viruses Medium 41902231
2016 PBX1 directly binds a PBX1 recognition element (PRE) between -144 and -99 upstream of the RNF6 transcription start site and, in collaboration with PREP1 (but not MEIS1), activates RNF6 transcription; mutation of the PRE completely abolishes RNF6 transcription. Doxorubicin suppresses RNF6 expression by down-regulating PBX1. Luciferase reporter assay with truncated RNF6 promoter constructs, PRE mutation, ChIP, knockdown experiments The Journal of biological chemistry Medium 26971355

Source papers

Stage 0 corpus · 38 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. Cancer cell 191 19345326
2005 The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones. Genes & development 90 16204183
2018 RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3. Cancer research 79 29374067
2016 The Ring Finger Protein RNF6 Induces Leukemia Cell Proliferation as a Direct Target of Pre-B-cell Leukemia Homeobox 1. The Journal of biological chemistry 53 26971355
2019 MicroRNA-26a-5p inhibits breast cancer cell growth by suppressing RNF6 expression. The Kaohsiung journal of medical sciences 39 31063232
2018 RNF6 facilitates metastasis and radioresistance in hepatocellular carcinoma through ubiquitination of FoxA1. Experimental cell research 29 30496760
2002 Identification of somatic mutations of the RNF6 gene in human esophageal squamous cell carcinoma. Cancer research 29 12154016
2018 Knockdown of RNF6 inhibits gastric cancer cell growth by suppressing STAT3 signaling. OncoTargets and therapy 28 30323630
2019 RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination. Acta pharmacologica Sinica 25 31645658
1999 Cloning and characterization of RNF6, a novel RING finger gene mapping to 13q12. Genomics 23 10331950
2018 Saponins From Paris forrestii (Takht.) H. Li Display Potent Activity Against Acute Myeloid Leukemia by Suppressing the RNF6/AKT/mTOR Signaling Pathway. Frontiers in pharmacology 16 29997504
2002 Gene control in germinal differentiation: RNF6, a transcription regulatory protein in the mouse sertoli cell. Molecular and cellular biology 16 11971979
2020 Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats. Brain and behavior 13 32955171
2021 RNF6 promotes colorectal cancer invasion and migration via the Wnt/β-catenin pathway by inhibiting GSK3β activity. Pathology, research and practice 12 34352441
2022 Induction of zinc finger protein RNF6 auto-ubiquitination for the treatment of myeloma and chronic myeloid leukemia. The Journal of biological chemistry 11 35926709
2023 RNF6 promotes gastric cancer progression by regulating CCNA1/CREBBP transcription. Cell cycle (Georgetown, Tex.) 10 37904524
2022 Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6. Pharmaceutics 10 35456636
2021 RNF6 promotes the migration and invasion of breast cancer by promoting the ubiquitination and degradation of MST1. Experimental and therapeutic medicine 10 34970341
2023 RNF6 activates TGF-β1/c-Myb pathway to promote EMT in esophageal squamous cell carcinoma. Frontiers in oncology 7 36845743
2021 Gene commander in the trash heap: Transcriptional regulation and ubiquitination modification mediated by RNF6 in carcinogenesis. Experimental cell research 7 33485842
2022 Glaucocalyxin A Inhibits the Malignancies of Gastric Cancer Cells by Downregulating MDM2 and RNF6 via MiR-3658 and the SMG1-UPF mRNA Decay Pathway. Frontiers in oncology 6 35814430
2021 Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling. FEBS open bio 6 34081837
2024 The E3 ubiquitin ligase RNF6 facilitates the progression of cervical cancer by inhibiting the Hippo/Yap pathway. Cell division 5 39551725
2022 E3 ubiquitin ligase RNF6 promotes antiviral immune responses through enhancing the expression of interferon stimulated genes in myeloid cells. Clinical immunology (Orlando, Fla.) 5 35973638
2022 QKI degradation in macrophage by RNF6 protects mice from MRSA infection via enhancing PI3K p110β dependent autophagy. Cell & bioscience 5 36088389
2021 RNF6 enhances radioresistance in colorectal cancer via activating the Wnt pathway. Journal of B.U.ON. : official journal of the Balkan Union of Oncology 4 34761601
2020 RNF6 as an Oncogene and Potential Therapeutic Target-A Review. Biotech (Basel (Switzerland)) 4 35822825
2025 RNF6 promotes cell proliferation of glioblastoma by targeting ubiquitin-mediated degradation of p27. Biochemical and biophysical research communications 3 39938447
2025 CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1-Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 3 40231770
2020 RNF6 serves as a diagnostic hallmark of non-alcoholic fatty liver disease with hepatocellular carcinoma: a clinical research. European review for medical and pharmacological sciences 3 33215420
2008 Cloning and identification of a novel RNF6 transcriptional splice variant Spg2 in human development. Science in China. Series C, Life sciences 3 18368307
2025 RNF6 Inhibits Lung Adenocarcinoma Cell Proliferation by Promoting Cyclin D2 Degradation. Molecular cancer research : MCR 2 39918413
2022 RNF6 Targeted by miR-26a-5p Protects Pancreatic β-Cell Function Against Type 2 Diabetes. Diabetes, metabolic syndrome and obesity : targets and therapy 2 35046680
2025 Albanol B inhibits glioblastoma progression by inducing senescence and apoptosis via the RNF6/p27 signaling axis. Phytomedicine : international journal of phytotherapy and phytopharmacology 1 40743902
2023 Non-adherent culture method affects the proliferation and apoptosis of mesenchymal stem cells through inhibiting LINC00707 to promote RNF6-mediated QKI ubiquitination. Experimental cell research 1 38072302
2026 RNF6 activates JNK/c-JUN pathway in ovarian cancer by promoting K48-linked NME4 ubiquitination. Pathology, research and practice 0 41616518
2026 Tree Shrew Genome-Wide CRISPR Screen Identifies RNF6 as a Proviral Host Factor for Zika Virus Replication in Brain Microvascular Endothelial Cells. Viruses 0 41902231
2026 Regulation of OTULIN ubiquitination by RNF6 alleviates asthma via mitigating epithelial-mesenchymal transition‑like phenotypic changes. Biochemical pharmacology 0 42055142

Missed literature

Know a paper Affinage missed for RNF6? Flag it for the maintainers and the community.

No submissions yet.