Affinage

RIC8B

Chaperone Ric-8B · UniProt Q9NVN3

Length
520 aa
Mass
58.8 kDa
Annotated
2026-06-10
50 papers in source corpus 16 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RIC8B is a molecular chaperone and non-receptor guanine nucleotide exchange factor (GEF) that controls the biosynthesis, folding, and steady-state abundance of Gαs/olf-type G protein α subunits and thereby amplifies Gαs/olf-dependent signaling (PMID:15829631, PMID:21467038, PMID:22114146). As a GEF, purified Ric-8B stimulates GDP release and GTPγS binding on Gαs and Gαolf in a GTP-dependent reaction, forming a tight nucleotide-free intermediate that is resolved by near-Km GTP (PMID:21467038), and it folds nascent Gα subunits during translation into properly folded, functional species (PMID:23431197). Independently of nucleotide exchange, Ric-8B maintains Gαs protein levels by binding it and inhibiting its ubiquitination, such that loss of Ric-8B reduces Gαs protein without affecting mRNA (PMID:20133939, PMID:22114146); this protective binding also mediates Gq–Gs crosstalk, because Gαq competes with Gαs for Ric-8B and Ric-8B can cancel Gαq-induced Gαs degradation (PMID:24134321). Physiologically, Ric-8B is required for olfactory signal transduction—enabling odorant receptor surface expression and ciliary Gαolf accumulation (PMID:16754875, PMID:18462949), with conditional deletion in olfactory sensory neurons abolishing Gαolf and impairing olfaction (PMID:29118104)—and for cardiac β-adrenergic responsiveness, where cardiac deletion phenocopies Gαs loss (PMID:38879012). Cryo-EM structures of Ric-8B bound to Gαs and Gαolf show that it cradles the Gα C-terminal α5 helix in a concave α-helical-repeat pocket and contacts an extended loop unique to Gαs/olf, accounting for its isoform selectivity (PMID:36931277). RIC8B transcription is regulated through promoter CRE and C/EBP elements by CREB1 and C/EBPβ (PMID:21606199, PMID:26729411).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2005 Medium

    Established the first molecular partner and function for Ric-8B by showing it engages Gαolf and enhances downstream signaling, placing it in the olfactory transduction pathway.

    Evidence Yeast two-hybrid interaction and cAMP accumulation assay in HEK293 cells

    PMID:15829631

    Open questions at the time
    • Did not establish whether the interaction is direct GEF activity or indirect
    • No structural or kinetic basis for the interaction
    • Limited to a heterologous cell context
  2. 2006 Medium

    Showed Ric-8B has a cell-biological role in receptor coupling by promoting functional odorant receptor surface expression and peripheral Gαolf accumulation, linking it to OR–G protein coupling.

    Evidence Heterologous expression and immunolocalization assays

    PMID:16754875

    Open questions at the time
    • Mechanism connecting Ric-8B to OR trafficking unresolved
    • Did not separate chaperone from GEF contributions
    • Heterologous cells, not native olfactory neurons
  3. 2008 Medium

    Defined the native localization and binding properties of Ric-8B, showing ciliary co-localization with the olfactory heterotrimeric G protein and nucleotide-dependent Gαolf binding consistent with a GEF.

    Evidence Co-immunoprecipitation, olfactory cilia immunofluorescence, nucleotide-dependent binding assay

    PMID:18462949

    Open questions at the time
    • Did not biochemically demonstrate GEF catalysis
    • Functional significance of Gγ13 interaction unclear
    • No in vivo loss-of-function
  4. 2010 Medium

    Revealed a degradation-protective function distinct from signaling: Ric-8B binding stabilizes Gαs protein by inhibiting its ubiquitination, with binding-deficient splice variants failing to protect.

    Evidence siRNA knockdown, overexpression, ubiquitination assay, protein/mRNA quantification with binding-deficient mutants

    PMID:20133939

    Open questions at the time
    • Ubiquitin ligase responsible for Gαs degradation not identified
    • Did not separate chaperone folding from stabilization mechanistically
    • Single cell system
  5. 2011 High

    Demonstrated direct GEF catalysis and chaperone-dependent biosynthesis: purified Ric-8B drives GDP release on multiple Gα subunits via a GTP-dependent mechanism, and genetic knockout reduces steady-state Gαs protein without lowering mRNA.

    Evidence In vitro GEF/GTPγS binding assays with purified protein and Michaelis-Menten kinetics; Ric-8B knockout ES cells with Western blot and RT-PCR

    PMID:21467038 PMID:22114146

    Open questions at the time
    • Structural basis of nucleotide release not yet defined
    • Relationship between in vitro broad Gα activity and in vivo isoform specificity unresolved
    • Whether GEF and chaperone activities are mechanistically separable not addressed
  6. 2011 Medium

    Identified transcriptional repression of the Ric-8B promoter during osteoblast differentiation by C/EBPβ and SWI/SNF, establishing chromatin-level control of Ric-8B expression.

    Evidence Promoter-luciferase, siRNA knockdown, ChIP, and nucleosome positioning assays in osteoblastic cells

    PMID:21606199

    Open questions at the time
    • Functional consequence of Ric-8B repression for osteoblast biology not established
    • Restricted to one cell lineage
  7. 2013 High

    Resolved the chaperone mechanism by showing Ric-8 folds nascent Gα subunits co-translationally, preventing aggregation and yielding functional GTP-loadable protein.

    Evidence Cell-free translation, immunodepletion/add-back, trypsinolysis protection, gel filtration, GTPγS binding

    PMID:23431197

    Open questions at the time
    • Study focused on Ric-8A; direct demonstration of Ric-8B folding Gαs/olf co-translationally not shown here
    • How chaperone handoff to membrane occurs unknown
  8. 2013 Medium

    Established Ric-8B as a node of Gq–Gs crosstalk by showing Gαq competes for Ric-8B and Ric-8B reverses Gαq-induced Gαs degradation in cardiomyocytes.

    Evidence Ubiquitination and cAMP assays in neonatal rat cardiomyocytes plus in vitro competitive binding

    PMID:24134321

    Open questions at the time
    • Stoichiometry and regulation of competition in vivo not defined
    • Physiological context of crosstalk under pathological signaling unaddressed
  9. 2017 High

    Provided in vivo proof that Ric-8B is required for olfactory function through maintenance of Gαolf, with neuronal loss and behavioral deficits upon conditional deletion.

    Evidence OMP-Cre conditional knockout mouse with Western blot, immunohistochemistry, and behavioral testing

    PMID:29118104

    Open questions at the time
    • Cause of neuronal death (signaling loss vs. unfolded Gα stress) not dissected
    • Did not separate chaperone from GEF role in vivo
  10. 2020 Medium

    Uncovered an unexpected link between Ric-8B and mTORC2 signaling, broadening its functional scope beyond Gαs/olf biology.

    Evidence Ric-8B hypomorphic mouse and cell knockdown with phospho-Akt(Ser473) Western blot and RNA-seq

    PMID:32392211

    Open questions at the time
    • Direct molecular connection between Ric-8B and mTORC2 not established
    • Whether effect is G protein-dependent unknown
  11. 2023 High

    Defined the structural basis of isoform selectivity, showing Ric-8B cradles the Gα α5 helix and uniquely contacts a Gαs/olf-specific loop, distinguishing it from Ric-8A specificity.

    Evidence Cryo-EM of Ric-8B:Gαs and Ric-8B:Gαolf complexes with thermal stability and cell-based folding assays

    PMID:36931277

    Open questions at the time
    • Structures capture chaperone/intermediate states; coupling to catalytic GDP release cycle not fully resolved
    • Dynamics of substrate handoff not captured
  12. 2024 Medium

    Showed that disease mutations in another Gα (Gαo) create a neomorphic gain-of-interaction with Ric-8B, redistributing it to the Golgi and disrupting neuronal G protein networks in a severity-correlated manner.

    Evidence Co-IP, subcellular localization imaging, GTP binding/hydrolysis assays across >80 Gαo mutants

    PMID:38874642

    Open questions at the time
    • Causal contribution of Ric-8B sequestration to neuronal dysfunction not demonstrated in vivo
    • Mechanism of Golgi redistribution unresolved
  13. 2024 High

    Demonstrated a non-olfactory physiological requirement: cardiac Ric-8B deletion selectively impairs Gαs-dependent β-adrenergic signaling and contractility, phenocopied by Gαs deletion.

    Evidence Conditional cardiac knockout with echocardiography, histology, phosphoproteomics, FRET interaction assay, and parallel Gnas knockout

    PMID:38879012

    Open questions at the time
    • Whether cardiac phenotype reflects loss of chaperone vs. GEF activity not dissected
    • Relevance to human cardiac disease not established
  14. 2026 Low

    Indicated that a RIC8B splice variant lacking the cradle loop helix domain acts as a dominant-negative suppressor of OR cAMP signaling, implicating the CLH domain in productive Gαs engagement.

    Evidence HEK293T odorant-induced cAMP assay with variant 4 and AlphaFold3 modeling

    PMID:41665873

    Open questions at the time
    • Dominant-negative misfolding mechanism rests on computational prediction only
    • No biochemical or structural validation of the CLH contact model
    • Single lab, single assay

Open questions

Synthesis pass · forward-looking unresolved questions
  • How Ric-8B's distinct activities—co-translational folding, GEF catalysis, and ubiquitination protection—are mechanistically partitioned and coordinated across the Gα life cycle in vivo remains unresolved.
  • No mechanism separating chaperone from GEF function in living cells
  • Identity of the ubiquitin ligase acting on Gαs unknown
  • Molecular basis of the Ric-8B–mTORC2 link undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0044183 protein folding chaperone 3 GO:0098772 molecular function regulator activity 3 GO:0140096 catalytic activity, acting on a protein 2
Localization
GO:0005794 Golgi apparatus 1 GO:0005829 cytosol 1 GO:0005929 cilium 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-392499 Metabolism of proteins 3
Partners
GNALGNAO1GNAQGNASGNB1GNG13

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 Ric-8B interacts with Gαolf (identified by yeast two-hybrid) and potentiates Gαolf-dependent cAMP accumulation in HEK293 cells, demonstrating it functions as a GEF activator in the olfactory signal transduction pathway. Yeast two-hybrid, cAMP accumulation assay in HEK293 cells The Journal of neuroscience Medium 15829631
2006 Ric-8B promotes functional heterologous expression of odorant receptors (ORs) on the cell surface and enhances accumulation of Gαolf at the cell periphery, suggesting it enables OR coupling to Gαolf. Heterologous expression assay, cell surface receptor expression, fluorescence/immunolocalization Proceedings of the National Academy of Sciences of the United States of America Medium 16754875
2008 Ric-8B physically interacts with Gγ13 (in addition to Gαolf) and co-localizes with Gαolf, Gβ1, and Gγ13 in cilia of olfactory sensory neurons; Ric-8B interaction with Gαolf is nucleotide-dependent, consistent with a GEF role. Co-immunoprecipitation, immunofluorescence localization in olfactory cilia, nucleotide-dependent binding assay Molecular and cellular neurosciences Medium 18462949
2010 Ric-8B stabilizes Gαs protein by inhibiting its ubiquitination; Ric-8B knockdown reduces Gαs protein (not mRNA), overexpression increases it, and Ric-8B binding to Gαs is required for this protective effect since splicing variants that cannot bind Gαs fail to inhibit ubiquitination. siRNA knockdown, overexpression, ubiquitination assay, Gαs protein/mRNA quantification The Journal of biological chemistry Medium 20133939
2011 Purified Ric-8B isoforms (full-length and Δ9) act as GDP release factors/GEFs for Gα subunits: Ric-8BFL stimulates GTPγS binding to Gαs, Gαq, Gα13, and Gαolf; elevates Vmax of Gαs GTP hydrolysis; and the reaction is GTP-dependent, requiring near-Km GTP to release the tight Ric-8B·nucleotide-free Gα intermediate. In vitro GEF assay (GTPγS binding), Michaelis-Menten kinetics of GTP hydrolysis, Co-IP with endogenous Gαs in HeLa cells The Journal of biological chemistry High 21467038
2011 Ric-8B functions as a molecular chaperone for Gα subunit biosynthesis: Ric-8B knockout ES cells show substantially reduced Gαs protein (without reduced mRNA), indicating Ric-8B is required for maintaining steady-state Gαs abundance. Ric-8B knockout ES cells derived from blastocysts, Western blot for Gα protein levels, RT-PCR for mRNA levels Science signaling High 22114146
2013 Ric-8A folds nascent Gα subunits during translation; in Ric-8A-depleted rabbit reticulocyte lysate, Gαi, Gαq, and Gα13 (but not Gαs) are improperly folded (trypsin-sensitive). In wheat germ extract (no endogenous Ric-8), Gαq forms aggregates unless Ric-8A is supplemented, whereupon it forms a ~100 kDa Ric-8A:Gαq heterodimer that releases functional Gαq-GTPγS upon GTP addition. This demonstrates the molecular chaperoning function of Ric-8 in folding nascent Gα subunits. Cell-free translation (rabbit reticulocyte lysate and wheat germ extract), immunodepletion, limited trypsinolysis protection assay, gel filtration, GTPγS binding Proceedings of the National Academy of Sciences of the United States of America High 23431197
2013 In cardiac myocytes, Gαq signaling promotes ubiquitination and degradation of Gαs; co-expression of Ric-8B cancels Gαq-induced Gαs ubiquitination and restores cAMP accumulation. In vitro, Gαq competes with Gαs for binding to Ric-8B, defining a crosstalk mechanism between Gq and Gs pathways mediated by Ric-8B. Ubiquitination assay in neonatal rat cardiomyocytes, cAMP accumulation assay, in vitro competitive binding assay Genes to cells Medium 24134321
2017 Conditional deletion of Ric-8b specifically in olfactory sensory neurons (OMP-Cre) eliminates Gαolf protein expression in the olfactory epithelium, reduces the mature olfactory sensory neuron layer, increases neuronal cell death, and causes impaired olfactory-guided behavior in mice. Conditional knockout mouse (OMP-Cre × Ric-8b floxed), Western blot, immunohistochemistry, behavioral testing The Journal of neuroscience High 29118104
2020 Ric-8B hypomorphic mutation in mice reduces mTORC2 activity, as shown by decreased phosphorylation of Akt at Ser473 in mutant embryos and in cultured cells with Ric-8B knockdown, revealing an unexpected role for Ric-8B in mTORC2 regulation. Ric-8B hypomorphic mouse model, phospho-Akt (Ser473) western blot, siRNA knockdown in cell lines, RNA-seq PLoS genetics Medium 32392211
2023 Cryo-EM structures of Ric-8B in complex with Gαs and Gαolf revealed that Ric-8B accommodates the Gα C-terminal α5 helix in a concave pocket formed by its α-helical repeat elements and distinctly contacts an extended loop unique to Gαs/olf proteins, explaining Ric-8B isoform specificity for Gαs/olf versus Ric-8A specificity for Gαi/o, Gα12/13, and Gαq/11. Cryo-EM structure determination, thermal stability assays, cell-based Gαolf folding assay Structure High 36931277
2024 Pathogenic GNAO1 encephalopathy mutations in Gαo cause neomorphic gain-of-interaction with Ric-8B (normally only responsible for Gαs/olf), redistributing Ric-8B from cytoplasm to Golgi and imbalancing neuronal G protein signaling networks; the strength of Gαo-Ric-8B interaction correlates with disease severity. Co-immunoprecipitation, subcellular localization imaging, GTP binding/hydrolysis assays, functional characterization of >80 Gαo mutants The Journal of clinical investigation Medium 38874642
2024 Conditional deletion of Ric-8b in adult mouse cardiac tissue leads to severely reduced contractility, cardiac fibrosis, apoptosis, loss of β-adrenergic L-type calcium channel activation, and downregulation of myosin light chain 2 phosphopeptides. FRET-based assays confirmed selective Ric-8b interaction with Gαs, and conditional Gαs (Gnas) deletion produced an equivalent cardiac phenotype. Conditional cardiac knockout mouse, echocardiography, histology, RNA-seq, phosphoproteomics, FRET-based interaction assay, parallel Gnas conditional knockout The Journal of biological chemistry High 38879012
2026 RIC8B variant 4 (v4), which lacks the C-terminal cradle loop helix (CLH) domain, suppresses odorant-induced cAMP responses, while variant 1 (full-length) supports OR signaling. AlphaFold3 modeling suggests v4 cannot form hydrogen bonds with Gαs via the CLH domain, potentially producing a dominant-negative misfolded Gαs. HEK293T heterologous expression, odorant-induced cAMP assay, AlphaFold3 structural prediction Bioscience, biotechnology, and biochemistry Low 41665873
2011 The Ric-8B gene promoter is repressed during osteoblast differentiation by the transcription factor C/EBPβ (LAP* isoform) and by the SWI/SNF chromatin-remodeling complex; C/EBPβ knockdown increases endogenous Ric-8B transcription; nucleosome repositioning accompanies repression. Promoter-luciferase assay, siRNA knockdown, ChIP, nucleosome positioning assay in osteoblastic cells Molecular and cellular biology Medium 21606199
2016 CREB1 binds proximal CRE sites in the human RIC8B gene promoter (confirmed by ChIP in neuroblastoma cells) and positively regulates RIC8B transcriptional activity, while C/EBPβ binds distal C/EBP sites; luciferase assays identified CRE sites as the dominant elements for basal transcriptional activity. Luciferase reporter assay, ChIP, protein-DNA interaction (EMSA-type) analysis Journal of cellular biochemistry Medium 26729411

Source papers

Stage 0 corpus · 50 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos. Cell 161 15479639
2000 RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system. Neuron 118 10985349
2005 Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division. Nature cell biology 114 16228010
2000 A role for RIC-8 (Synembryn) and GOA-1 (G(o)alpha) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans. Genetics 107 11102364
2005 Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins. Nature cell biology 106 16228012
2011 Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association. Science signaling 104 22114146
2005 Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins. Nature cell biology 99 16228011
2004 Mutations that rescue the paralysis of Caenorhabditis elegans ric-8 (synembryn) mutants activate the G alpha(s) pathway and define a third major branch of the synaptic signaling network. Genetics 99 15489510
2005 Ric-8B, an olfactory putative GTP exchange factor, amplifies signal transduction through the olfactory-specific G-protein Galphaolf. The Journal of neuroscience : the official journal of the Society for Neuroscience 90 15829631
2006 Ric-8B promotes functional expression of odorant receptors. Proceedings of the National Academy of Sciences of the United States of America 89 16754875
2004 Control of embryonic spindle positioning and Galpha activity by C. elegans RIC-8. Current biology : CB 83 15498497
2005 Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division. Development (Cambridge, England) 73 16162648
2013 Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits. Proceedings of the National Academy of Sciences of the United States of America 64 23431197
2011 Ric-8B is a GTP-dependent G protein alphas guanine nucleotide exchange factor. The Journal of biological chemistry 58 21467038
2008 Ric-8B interacts with G alpha olf and G gamma 13 and co-localizes with G alpha olf, G beta 1 and G gamma 13 in the cilia of olfactory sensory neurons. Molecular and cellular neurosciences 49 18462949
2010 Ric-8B stabilizes the alpha subunit of stimulatory G protein by inhibiting its ubiquitination. The Journal of biological chemistry 44 20133939
2013 Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis. Proceedings of the National Academy of Sciences of the United States of America 39 23576747
2013 Ric-8 regulation of heterotrimeric G proteins. Journal of receptor and signal transduction research 38 23384070
2014 The G protein α chaperone Ric-8 as a potential therapeutic target. Molecular pharmacology 36 25319541
2021 Ric8 acts as a regulator of G-protein signalling required for nematode-trapping lifecycle of Arthrobotrys oligospora. Environmental microbiology 35 34431203
2011 RIC8 is a guanine-nucleotide exchange factor for Galpha subunits that regulates growth and development in Neurospora crassa. Genetics 32 21750256
2010 Nucleotide exchange factor RIC-8 is indispensable in mammalian early development. Developmental dynamics : an official publication of the American Association of Anatomists 31 21069829
2005 Ric-8 enhances G protein betagamma-dependent signaling in response to betagamma-binding peptides in intact cells. Molecular pharmacology 29 15802611
2012 Ric-8: different cellular roles for a heterotrimeric G-protein GEF. Journal of cellular biochemistry 26 22511245
2011 AGS-3 alters Caenorhabditis elegans behavior after food deprivation via RIC-8 activation of the neural G protein G αo. The Journal of neuroscience : the official journal of the Society for Neuroscience 26 21832186
2003 Expression of ric-8 (synembryn) gene in the nervous system of developing and adult mouse. Gene expression patterns : GEP 24 12971991
2005 Heterozygous mice with Ric-8 mutation exhibit impaired spatial memory and decreased anxiety. Behavioural brain research 23 16221497
2014 Low levels of Gαs and Ric8b in testicular sertoli cells may underlie restricted FSH action during infancy in primates. Endocrinology 22 25549048
2013 Drosophila Ric-8 interacts with the Gα12/13 subunit, Concertina, during activation of the Folded gastrulation pathway. Molecular biology of the cell 20 24006487
2016 A Model for Direction Sensing in Dictyostelium discoideum: Ras Activity and Symmetry Breaking Driven by a Gβγ-Mediated, Gα2-Ric8 -- Dependent Signal Transduction Network. PLoS computational biology 19 27152956
2012 The guanine nucleotide exchange factor RIC8 regulates conidial germination through Gα proteins in Neurospora crassa. PloS one 19 23118921
2024 Neomorphic Gαo mutations gain interaction with Ric8 proteins in GNAO1 encephalopathies. The Journal of clinical investigation 18 38874642
2014 A Ric8/synembryn homolog promotes Gpa1 and Gpa2 activation to respectively regulate cyclic AMP and pheromone signaling in Cryptococcus neoformans. Eukaryotic cell 18 25084863
2011 Cloning and spatiotemporal expression of RIC-8 in Xenopus embryogenesis. Gene expression patterns : GEP 18 21726669
2023 Structures of Ric-8B in complex with Gα protein folding clients reveal isoform specificity mechanisms. Structure (London, England : 1993) 15 36931277
2011 The Ric-8B gene is highly expressed in proliferating preosteoblastic cells and downregulated during osteoblast differentiation in a SWI/SNF- and C/EBPbeta-mediated manner. Molecular and cellular biology 15 21606199
2009 Biophysical studies support a predicted superhelical structure with armadillo repeats for Ric-8. Protein science : a publication of the Protein Society 14 19472323
2017 Conditional Deletion of Ric-8b in Olfactory Sensory Neurons Leads to Olfactory Impairment. The Journal of neuroscience : the official journal of the Society for Neuroscience 11 29118104
2013 Increased ubiquitination and the crosstalk of G protein signaling in cardiac myocytes: involvement of Ric-8B in Gs suppression by Gq signal. Genes to cells : devoted to molecular & cellular mechanisms 8 24134321
2023 The G protein alpha chaperone and guanine-nucleotide exchange factor RIC-8 regulates cilia morphogenesis in Caenorhabditis elegans sensory neurons. PLoS genetics 6 37910589
2014 A functional N-terminal domain in C/EBPβ-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts. Journal of cellular physiology 6 24585571
2015 Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis. PloS one 5 26062014
2025 Targeted Neuroprotection of Retinal Ganglion Cells Via AAV2-hSyn-NGF Gene Therapy in Glaucoma Models. Investigative ophthalmology & visual science 4 40244606
2016 The CREB Transcription Factor Controls Transcriptional Activity of the Human RIC8B Gene. Journal of cellular biochemistry 4 26729411
2024 RNAseq and targeted metabolomics implicate RIC8 in regulation of energy homeostasis, amino acid compartmentation, and asexual development in Neurospora crassa. mBio 2 39555920
2020 Depletion of Ric-8B leads to reduced mTORC2 activity. PLoS genetics 2 32392211
2026 Structural and functional analysis of RIC8B variants regulating olfactory receptor responses. Bioscience, biotechnology, and biochemistry 0 41665873
2026 Cell-specific roles for the conserved Galpha chaperone RIC-8 in cilia biology. bioRxiv : the preprint server for biology 0 41727026
2024 The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart. The Journal of biological chemistry 0 38879012
2023 The G protein alpha Chaperone and Guanine-Nucleotide Exchange Factor RIC-8 Regulates Cilia Morphogenesis in Caenorhabditis elegans Sensory Neurons. bioRxiv : the preprint server for biology 0 37662329

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