Affinage

RASIP1

Ras-interacting protein 1 · UniProt Q5U651

Length
963 aa
Mass
103.5 kDa
Annotated
2026-06-10
100 papers in source corpus 12 papers cited in narrative 12 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RASIP1 is an endothelial-enriched adaptor protein that links Ras-superfamily GTPase signaling to the control of vascular lumen formation, endothelial junction organization, and angiogenesis (PMID:21396893, PMID:26897025). It functions as a direct effector of RAP1 and RAS: its RA domain forms a dimer that binds two molecules of active RAP1 (KD ~0.9 μM) or RAS (KD ~2.2 μM) at the GTPase Switch I region, defining it as a cooperative, membrane-associated GTPase sensor (PMID:27839947), and it is recruited to nascent endothelial cell–cell contacts in an EPAC1–RAP1-dependent manner (PMID:23886837). Junctional tethering requires the transmembrane receptor HEG1, which binds a central region of RASIP1 and acts downstream of the Ccm1–Heg1 complex to localize RASIP1 to junctions; deletion of the HEG1-binding region abolishes junctional localization, ROCK inhibition, and barrier integrity (PMID:26780829, PMID:34383884). At the junction RASIP1 coordinates opposing GTPase pools during tubulogenesis: it activates a CDC42–PAK4–nonmuscle myosin II module to clear apical junctions during lumen opening, and then suppresses RhoA/ROCK/myosin II contractility through its partner ARHGAP29 to permit controlled vessel expansion and maintain barrier function (PMID:23798437, PMID:27486147). This activity is required for blood and lymphatic vessel lumenogenesis, tricellular and apical junction stability, and angiogenic sprouting, while being dispensable for established quiescent vessels (PMID:21396893, PMID:26897025, PMID:30042182, PMID:34383884).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2004 Medium

    Established that RASIP1 is a GTP-dependent Ras effector, answering whether it physically and functionally couples to active Ras.

    Evidence Co-IP, in vitro binding requiring an intact Ras effector domain, juxta-Golgi localization, and synergistic NIH3T3 transformation with activated Raf

    PMID:15031288

    Open questions at the time
    • Did not connect Ras binding to a vascular function
    • Endomembrane localization not reconciled with later junctional localization
    • No structural basis for the interaction
  2. 2009 Medium

    Demonstrated that RASIP1 is required for vessel formation, defining an endothelial-specific developmental role beyond cultured-cell transformation.

    Evidence siRNA knockdown in cultured endothelial cells and morpholino knockdown in Xenopus embryos

    PMID:19272373

    Open questions at the time
    • Molecular mechanism of the vascular requirement undefined
    • GTPase effector linkage to the phenotype not established
  3. 2011 High

    Defined the core mechanism: RASIP1 controls vascular lumen formation by partnering with the RhoGAP ARHGAP29 to suppress RhoA/ROCK/myosin II and promote Cdc42/Rac1.

    Evidence Rasip1 knockout mice, EC siRNA depletion, in vitro lumen assays, RhoA/Cdc42/Rac1 activity assays, Par3 localization

    PMID:21396893

    Open questions at the time
    • Upstream GTPase activating RASIP1 not identified
    • Mechanism recruiting RASIP1 to membranes/junctions unknown
  4. 2013 High

    Identified RAP1 as the activating GTPase and placed RASIP1 within the EPAC1–RAP1 pathway controlling endothelial junctions and barrier function.

    Evidence FRET interaction with active Rap1, endogenous Co-IP, EPAC1-RAP1 junction-formation model, barrier permeability and Rho activity assays, zebrafish/mouse analysis

    PMID:23798437 PMID:23886837

    Open questions at the time
    • How RAP1 binding translates to ARHGAP29 regulation mechanistically unclear
    • Structural basis of Rap1 recognition not resolved
  5. 2016 High

    Established the junctional recruitment mechanism and the stepwise GTPase logic, showing HEG1 tethers RASIP1 to junctions and RASIP1 sequentially drives CDC42-PAK4-NMII then ARHGAP29-mediated RhoA suppression.

    Evidence HEG1 proteomic screen, direct binding and mitochondrial relocalization, deletion mutagenesis, conditional Rasip1/Cdc42 knockouts, Pak4/NMII pharmacology, ROCK and junction assays

    PMID:26780829 PMID:26897025 PMID:27486147

    Open questions at the time
    • How a single adaptor temporally switches between opposing GTPase pools is not fully resolved
    • Requirement is context-dependent (angiogenesis vs quiescent vessels) by unknown determinants
  6. 2016 High

    Provided the structural basis for RASIP1 acting as a cooperative GTPase sensor, showing its RA domain dimerizes to bind two RAP1 or RAS molecules at Switch I.

    Evidence X-ray crystallography of the RRA domain alone and with Rap1 at 2.8 Å, with quantitative affinity measurements (Rap1 KD 0.9 μM, Ras KD 2.2 μM)

    PMID:27839947

    Open questions at the time
    • Functional consequence of cooperative dimeric binding in cells not directly tested
    • Selectivity between Rap1 and Ras in vivo not resolved
  7. 2018 High

    Extended RASIP1 function to the lymphatic system and confirmed CDC42 as a key downstream effector via genetic rescue.

    Evidence Lymphatic EC-specific conditional knockout, junction/cytoskeleton assays, Cdc42 activity assay, Cdc42 rescue of the deficient phenotype

    PMID:30042182

    Open questions at the time
    • Whether lymphatic and blood vessel mechanisms are identical not established
    • Role in valve formation mechanistically undefined
  8. 2018 Medium

    Revealed transcriptional and growth-factor control of RASIP1 and a role in cancer cell migration, broadening its context beyond vascular development.

    Evidence ChIP and luciferase reporter showing RUNX1 binds the Rasip1 promoter, siRNA, migration assays, Rac1 activity, EGFR-dependent expression/localization in NSCLC cells

    PMID:30349386

    Open questions at the time
    • Generality of RUNX1/EGFR regulation across cell types unknown
    • Single-lab cancer migration link not independently confirmed
  9. 2021 High

    Defined RASIP1's role in junction subcellular architecture and confirmed its dependence on the Ccm1–Heg1 complex for junctional localization.

    Evidence Zebrafish rasip1 mutants with live imaging of F-actin/junctions and epistasis with ccm1 and heg1

    PMID:34383884

    Open questions at the time
    • Molecular steps linking junctional tethering to apical compartment stability unresolved
    • Role of Ccm1 in the HEG1-RASIP1 binding interaction not biochemically defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RASIP1 temporally and spatially coordinates the switch between CDC42-driven junction clearance and ARHGAP29-mediated RhoA suppression at the molecular level remains unresolved.
  • No mechanism explaining how one adaptor sequentially activates opposing GTPase modules
  • Structural basis for ARHGAP29 binding and regulation not determined
  • Determinants of context-dependent requirement (angiogenic vs quiescent) unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0098772 molecular function regulator activity 3 GO:0140299 molecular sensor activity 3
Localization
GO:0005886 plasma membrane 3 GO:0005794 Golgi apparatus 1
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-1500931 Cell-Cell communication 3 R-HSA-162582 Signal Transduction 3
Partners
ARHGAP29CDC42HEG1RAP1RAS

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 RASIP1 (Rain/Rasip1) interacts with Ras in a GTP-dependent manner in vitro and in vivo, requires an intact Ras core effector-binding domain for this interaction, and localizes to perinuclear, juxta-Golgi vesicles in intact cells; activated Ras recruits Rasip1 to the Golgi. Rasip1 cooperates with activated Raf to cause synergistic transformation of NIH3T3 cells, consistent with a role as a Ras effector at endomembranes. Co-IP, in vitro binding assays, live-cell imaging/immunofluorescence localization, NIH3T3 transformation assay The Journal of biological chemistry Medium 15031288
2009 siRNA-mediated knockdown of Rasip1 in endothelial cell cultures severely impairs angiogenesis and cell motility; morpholino knockdown in Xenopus embryos demonstrates that Rasip1 is required for embryonic vessel formation in vivo, establishing an endothelial-specific role in vascular development. siRNA knockdown in cultured endothelial cells (angiogenesis/motility assays), morpholino knockdown in Xenopus embryos Developmental biology Medium 19272373
2011 Rasip1 null mice fail to form patent vascular lumens in all blood vessels. Rasip1 acts through its binding partner RhoGAP Arhgap29 to suppress RhoA/ROCK/myosin II activity and promote Cdc42 and Rac1 signaling. Loss of Rasip1 or Arhgap29 in cultured ECs blocks lumen formation, alters cytoskeletal organization, and reduces integrin-dependent ECM adhesion. Rasip1 null angioblasts fail to properly localize the polarity determinant Par3. Rasip1 knockout mice, siRNA depletion of Rasip1/Arhgap29 in cultured ECs, in vitro lumen formation assay, RhoA/Cdc42/Rac1 activity assays, immunofluorescence Developmental cell High 21396893
2013 Rasip1 is a direct Rap1 effector: FRET experiments show Rasip1 interacts with active Rap1 in a cellular context. Rasip1 mediates Rap1-induced cell spreading by engaging its binding partner ArhGAP29 to inhibit Rho signaling. The Rasip1–ArhGAP29 pathway operates in Rap1-mediated regulation of endothelial junctions and endothelial barrier function, suppressing Rho-mediated stress fiber formation. FRET-based interaction assay, siRNA knockdown, cell spreading assays, endothelial barrier permeability assays, Rho activity assays Proceedings of the National Academy of Sciences of the United States of America High 23798437
2013 Endogenous RASIP1 in endothelial cells binds RAP1 (but not RhoA or Cdc42 directly). RASIP1 localizes to nascent cell-cell contacts in an EPAC1-RAP1-dependent manner. Loss of RASIP1 alters junctional actin organization and localization of nonmuscle myosin heavy chain IIB, and phenocopies loss of RAP1 or EPAC1, placing RASIP1 as an effector of the EPAC1–RAP1 pathway at endothelial junctions. Co-IP of endogenous proteins, immunofluorescence localization, siRNA knockdown, EPAC1-RAP1 junction-formation model in ECs, zebrafish/mouse embryo analysis Blood High 23886837
2016 HEG1 (Heart of Glass) directly binds a central region of Rasip1 and is required to recruit Rasip1 to endothelial cell–cell junctions. Proteomic screen identified HEG1 as a Rasip1 interactor; mitochondria-targeted HEG1 relocalizes Rasip1 to mitochondria. A 9-residue sequence in HEG1 is necessary for Rasip1 binding; deletion of the HEG1-binding domain in Rasip1 eliminates junctional localization, ROCK inhibition, and EC junctional integrity. Proteomic screen for HEG1 interactors, direct binding assays, mitochondrial-targeting relocalization experiment, deletion mutagenesis, ROCK activity assay, EC junction integrity assay eLife High 26780829
2016 Rasip1 controls distinct GTPase pools during vascular tubulogenesis: (1) Rasip1 promotes Cdc42 activity, which activates Pak4, leading to nonmuscle myosin II (NMII) activation and clearance of apical junctions during lumen opening; (2) once lumens open, Rasip1 suppresses RhoA via Arhgap29, inhibiting actomyosin contractility to allow controlled vessel expansion. Conditional mouse mutants and pharmacological inhibition of Pak4 or NMII confirm these stepwise roles. Conditional mouse knockout of Rasip1 and Cdc42, pharmacological inhibition of Pak4 and NMII, epistasis analysis, immunofluorescence Circulation research High 27486147
2016 Rasip1 is required for angiogenesis (in vitro matrix invasion, postnatal retinal vessel growth, directed in vivo angiogenesis) but is dispensable for maintenance of established quiescent adult blood vessels, demonstrating a context-dependent requirement. Conditional endothelial-specific Rasip1 knockout mouse, retinal angiogenesis assay, directed in vivo angiogenesis assay, in vitro matrix invasion assay Angiogenesis High 26897025
2016 Crystal structure of the Rasip1 RA domain (RRA) was solved alone and in complex with Rap1 at 2.8 Å resolution. RRA forms a dimer that binds two Rap1 (KD = 0.9 μM) or Ras (KD = 2.2 μM) molecules. Rasip1 contacts Rap1 in the Switch I region; Rap1 binding stabilizes a β strand and an unstructured loop. This defines Rasip1 as a member of a subgroup of dimeric RA domains capable of cooperative binding to membrane-associated Ras superfamily members. X-ray crystallography (crystal structure), isothermal titration calorimetry or equivalent binding affinity measurements Structure (London, England : 1993) High 27839947
2018 Lymphatic endothelial cell-specific deletion of Rasip1 in mice causes enlarged, blood-filled lymphatics with disorganized junctions and, at later stages, fragmented lumens and defective lymphatic valve formation. Rasip1 regulates Cdc42 activity in lymphatic ECs; ectopic Cdc42 expression rescues the Rasip1-deficient phenotype, placing Rasip1 upstream of Cdc42 in lymphatic lumen maintenance and junction organization. Lymphatic EC-specific conditional Rasip1 knockout mouse, in vitro junction/cytoskeleton assays, Cdc42 activity assay, Cdc42 rescue experiment Development (Cambridge, England) High 30042182
2018 RUNX1 directly binds the Rasip1 promoter at a specific DNA sequence (demonstrated by ChIP and luciferase reporter assay) and activates Rasip1 transcription. Silencing Rasip1 inhibits the migration of RUNX1-overexpressing NSCLC cells through inactivation of the Rac1 pathway. EGFR signaling regulates both expression and subcellular localization of Rasip1 in lung cancer cells. ChIP with anti-RUNX1 antibody, luciferase reporter assay, siRNA knockdown, transwell/wound-healing migration assays, Rac1 activity assay, immunofluorescence Cancer management and research Medium 30349386
2021 In zebrafish rasip1 mutants, Rasip1 is required for: (1) stabilization of tricellular junctions during angiogenic sprouting to maintain multicellular organization; (2) establishment of a stable apical membrane compartment during anastomosis (loss causes ectopic reticulated junctions and collapsed apical compartment). Loss of Ccm1 and Heg1 phenocopies rasip1 junction defects; downregulation of ccm1 and heg1 delocalizes Rasip1 from cell junctions, placing Rasip1 downstream of the Ccm1–Heg1 complex for junctional tethering. Zebrafish rasip1 genetic mutants, live imaging of F-actin and junction dynamics, epistasis analysis with ccm1 and heg1 morphants/mutants, immunofluorescence Development (Cambridge, England) High 34383884

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 Detecting rhythms in time series with RAIN. Journal of biological rhythms 317 25326247
2009 Isolation, diversity, and antimicrobial activity of rare actinobacteria from medicinal plants of tropical rain forests in Xishuangbanna, China. Applied and environmental microbiology 245 19648362
2006 Leaf structural diversity is related to hydraulic capacity in tropical rain forest trees. Ecology 217 16637372
2011 Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling. Developmental cell 132 21396893
2013 Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29. Proceedings of the National Academy of Sciences of the United States of America 118 23798437
2012 Dispersal of Salmonella Typhimurium by rain splash onto tomato plants. Journal of food protection 74 22410220
2010 Variation in pH optima of hydrolytic enzyme activities in tropical rain forest soils. Applied and environmental microbiology 74 20709838
2008 Geographic, seasonal, and precipitation chemistry influence on the abundance and activity of biological ice nucleators in rain and snow. Proceedings of the National Academy of Sciences of the United States of America 58 19028877
2016 Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II. Circulation research 56 27486147
2017 Deep reticulation and incomplete lineage sorting obscure the diploid phylogeny of rain-lilies and allies (Amaryllidaceae tribe Hippeastreae). Molecular phylogenetics and evolution 55 28390909
2009 Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation. Developmental biology 55 19272373
2016 A Systematic Investigation of Parameters Influencing Droplet Rain in the Listeria monocytogenes prfA Assay - Reduction of Ambiguous Results in ddPCR. PloS one 51 27992475
2012 Global transcriptome response to ionic liquid by a tropical rain forest soil bacterium, Enterobacter lignolyticus. Proceedings of the National Academy of Sciences of the United States of America 51 22586090
2017 RAIN: RNA-protein Association and Interaction Networks. Database : the journal of biological databases and curation 50 28077569
2013 Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling. Blood 49 23886837
2004 Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. The Journal of biological chemistry 49 15031288
2002 HIV type 1 group M clades infecting subjects from rural villages in equatorial rain forests of Cameroon. Journal of acquired immune deficiency syndromes (1999) 47 12473838
2016 Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity. eLife 46 26780829
2014 Regulation of vascular endothelial junction stability and remodeling through Rap1-Rasip1 signaling. Cell adhesion & migration 44 24622510
2019 The Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles. Scientific reports 43 30728442
2014 Bacterial diversity and composition during rain events with and without Saharan dust influence reaching a high mountain lake in the Alps. Environmental microbiology reports 41 25756115
1997 Antioxidant responses to simulated acid rain and heavy metal deposition in birch seedlings. Environmental pollution (Barking, Essex : 1987) 40 15093466
1992 Nutritional ecology in the tropical rain forests of Amazonia. American journal of human biology : the official journal of the Human Biology Council 34 28524344
2017 Model-Based Classification for Digital PCR: Your Umbrella for Rain. Analytical chemistry 32 28350455
2003 Mechanics and chemistry of rain forest leaves: canopy and understorey compared. Journal of experimental botany 32 12867549
2018 Climate model shows large-scale wind and solar farms in the Sahara increase rain and vegetation. Science (New York, N.Y.) 31 30190404
2013 Populus yunnanensis males adopt more efficient protective strategies than females to cope with excess zinc and acid rain. Chemosphere 31 23415309
2012 Salmonella can reach tomato fruits on plants exposed to aerosols formed by rain. International journal of food microbiology 31 22831820
2009 Influence of leaf tolerance mechanisms and rain on boron toxicity in barley and wheat. Plant physiology 30 19625636
2003 Historical demography and genetic structure of sister species: deermice (Peromyscus) in the North American temperate rain forest. Molecular ecology 30 12675826
2021 Long-term cover crops improved soil phosphorus availability in a rain-fed apple orchard. Chemosphere 29 33652274
2018 Effect of exogenous calcium on growth, nutrients uptake and plasma membrane H+-ATPase and Ca2+-ATPase activities in soybean (Glycine max) seedlings under simulated acid rain stress. Ecotoxicology and environmental safety 29 30205327
2016 Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth. Angiogenesis 29 26897025
2020 Physiological and biochemical responses of tea seedlings (Camellia sinensis) to simulated acid rain conditions. Ecotoxicology and environmental safety 28 32058162
2005 Candida riodocensis and Candida cellae, two new yeast species from the Starmerella clade associated with solitary bees in the Atlantic rain forest of Brazil. FEMS yeast research 28 15925316
2018 Rasip1 is a RUNX1 target gene and promotes migration of NSCLC cells. Cancer management and research 26 30349386
2015 Effects of agricultural biodiversity and seasonal rain on dietary adequacy and household food security in rural areas of Kenya. BMC public health 26 25909468
2010 Effect of simulated acid rain on the litter decomposition of Quercus acutissima and Pinus massoniana in forest soil microcosms and the relationship with soil enzyme activities. The Science of the total environment 26 20382410
2019 Influences of stormwater concentration infiltration on soil nitrogen, phosphorus, TOC and their relations with enzyme activity in rain garden. Chemosphere 25 31173958
2016 A Solar Cell That Is Triggered by Sun and Rain. Angewandte Chemie (International ed. in English) 25 26996147
2001 Biological screening of rain forest plot trees from Palawan Island (Philippines). Phytomedicine : international journal of phytotherapy and phytopharmacology 25 11292242
2020 Rain induces temporary shifts in epiphytic bacterial communities of cucumber and tomato fruit. Scientific reports 24 32020033
2019 Risk-Reducing Bilateral Salpingo-Oophorectomy for BRCA Mutation Carriers and Hormonal Replacement Therapy: If It Should Rain, Better a Drizzle than a Storm. Medicina (Kaunas, Lithuania) 24 31362334
1985 Immunochemical comparison between worm extracts of Onchocerca volvulus from savanna and rain forest. Parasite immunology 24 4011303
2019 RAIN Is a Novel Enhancer-Associated lncRNA That Controls RUNX2 Expression and Promotes Breast and Thyroid Cancer. Molecular cancer research : MCR 23 31624086
2011 Influence of salinity on bacterioplankton communities from the Brazilian rain forest to the coastal Atlantic Ocean. PloS one 23 21408023
2005 Phylogeny of PgiC gene in Shorea and its closely related genera (Dipterocarpaceae), the dominant trees in Southeast Asian tropical rain forests. American journal of botany 23 21652457
2022 Effect of polyethylene microplastics and acid rain on the agricultural soil ecosystem in Southern China. Environmental pollution (Barking, Essex : 1987) 22 35245624
2018 Fecal source tracking and eDNA profiling in an urban creek following an extreme rain event. Scientific reports 22 30258068
2015 A protocol for the delimitation of areas of endemism and the historical regionalization of the Brazilian Atlantic Rain Forest using harvestmen distribution data. Cladistics : the international journal of the Willi Hennig Society 22 34753274
2007 Genetic diversity of ectomycorrhizal Basidiomycetes from African and Indian tropical rain forests. Mycorrhiza 22 17334790
2006 Examination of 2-DE in the Human Proteome Organisation Brain Proteome Project pilot studies with the new RAIN gel matching technique. Proteomics 22 16927431
2017 Extensive seed and pollen dispersal and assortative mating in the rain forest tree Entandrophragma cylindricum (Meliaceae) inferred from indirect and direct analyses. Molecular ecology 21 28734064
2014 Transcriptional regulation of abscisic acid signal core components during cucumber seed germination and under Cu²⁺, Zn²⁺, NaCl and simulated acid rain stresses. Plant physiology and biochemistry : PPB 20 24486581
2004 Limited effect of anthropogenic habitat fragmentation on molecular diversity in a rain forest skink, Gnypetoscincus queenslandiae. Molecular ecology 20 14717885
2024 Did the exposure of coacervate droplets to rain make them the first stable protocells? Science advances 19 39167649
2020 Comparative effects of the recovery from sulfuric and nitric acid rain on the soil enzyme activities and metabolic functions of soil microbial communities. The Science of the total environment 18 31982766
2019 Projected local rain events due to climate change and the impacts on waterborne diseases in Vancouver, British Columbia, Canada. Environmental health : a global access science source 18 31888648
2018 Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions. Development (Cambridge, England) 18 30042182
2016 Rain-Shelter Cultivation Modifies Carbon Allocation in the Polyphenolic and Volatile Metabolism of Vitis vinifera L. Chardonnay Grapes. PloS one 18 27218245
2012 RAIN-Droplet: a novel 3D in vitro angiogenesis model. Laboratory investigation; a journal of technical methods and pathology 18 22565576
2012 Bamboo shoots after the rain: development and challenges of autism intervention in China. Autism : the international journal of research and practice 18 23144167
2020 Exploring Rain as Source of Biological Control Agents for Fire Blight on Apple. Frontiers in microbiology 17 32117187
2019 Growth and physiological response of an endangered tree, Horsfieldia hainanensis merr., to simulated sulfuric and nitric acid rain in southern China. Plant physiology and biochemistry : PPB 17 31563092
2017 Response of Methanogenic Microbial Communities to Desiccation Stress in Flooded and Rain-Fed Paddy Soil from Thailand. Frontiers in microbiology 17 28529503
2013 Manipulation of ruminal fermentation and methane production by supplementation of rain tree pod meal containing tannins and saponins in growing dairy steers. Journal of animal physiology and animal nutrition 17 23294319
2011 Response of soybean seed germination to cadmium and acid rain. Biological trace element research 17 21479540
2003 Trophic partitioning in tropical rain forest birds: insights from stable isotope analysis. Oecologia 17 12802673
2023 An overview of the direct and indirect effects of acid rain on plants: Relationships among acid rain, soil, microorganisms, and plants. The Science of the total environment 16 36842576
2020 Capybara and Brush Cutter Involvement in Q Fever Outbreak in Remote Area of Amazon Rain Forest, French Guiana, 2014. Emerging infectious diseases 16 32310064
2010 Impacts of simulated acid rain on soil enzyme activities in a latosol. Ecotoxicology and environmental safety 16 20701974
2021 Extensive rain events have a more substantial impact than advanced effluent treatment on the endocrine-disrupting activity in an effluent-dominated small river. The Science of the total environment 15 34634343
2014 Comparative proteomic analysis of differential responses of Pinus massoniana and Taxus wallichiana var. mairei to simulated acid rain. International journal of molecular sciences 15 24625662
2009 Identifying and quantifying Phakopsora pachyrhizi spores in rain. Phytopathology 14 19271973
2009 beta-carboline alkaloid-enriched extract from the amazonian rain forest tree pao pereira suppresses prostate cancer cells. Journal of the Society for Integrative Oncology 14 19476740
2022 Emergency Medical Teams' Responses during the West Japan Heavy Rain 2018: J-SPEED Data Analysis. Prehospital and disaster medicine 13 35225205
2020 Response of soil chemical properties and enzyme activity of four species in the Three Gorges Reservoir area to simulated acid rain. Ecotoxicology and environmental safety 13 33120255
2019 Bartonella henselae and Bartonella clarridgeiae infection, hematological changes and associated factors in domestic cats and dogs from an Atlantic rain forest area, Brazil. Acta tropica 13 30825447
2017 Analysis of the combined effects of lanthanum and acid rain, and their mechanisms, on nitrate reductase transcription in plants. Ecotoxicology and environmental safety 13 28056417
2021 Calcium regulates antioxidative isozyme activity for enhancing rice adaption to acid rain stress. Plant science : an international journal of experimental plant biology 12 33775371
2021 Precise localization and dynamic distribution of Japanese encephalitis virus in the rain nuclei of infected mice. PLoS neglected tropical diseases 12 34153060
2020 Simulated sulfuric and nitric acid rain inhibits leaf breakdown in streams: A microcosm study with artificial reconstituted fresh water. Ecotoxicology and environmental safety 12 32224368
2015 Combined Effects of Lanthanum (III) and Acid Rain on Antioxidant Enzyme System in Soybean Roots. PloS one 12 26230263
2015 Trypanoxyuris atelis and T. atelophora (Nematoda: Oxyuridae) in wild spider monkeys (Ateles geoffroyi) in tropical rain forest in Mexico: Morphological and molecular evidence. Parasitology international 11 25748278
2019 Comparison of plasma membrane H+-ATPase response to acid rain stress between rice and soybean. Environmental science and pollution research international 10 31873880
2016 Platinum Alloy Tailored All-Weather Solar Cells for Energy Harvesting from Sun and Rain. Angewandte Chemie (International ed. in English) 10 27739638
2016 Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins. Structure (London, England : 1993) 10 27839947
2021 Control of dynamic cell behaviors during angiogenesis and anastomosis by Rasip1. Development (Cambridge, England) 9 34383884
2020 Low-coverage genomic data resolve the population divergence and gene flow history of an Australian rain forest fig wasp. Molecular ecology 9 32567765
2016 Effects of simulated acid rain on soil respiration and its components in a subtropical mixed conifer and broadleaf forest in southern China. Environmental science. Processes & impacts 9 26755128
2016 Responses of tropical legumes from the Brazilian Atlantic Rainforest to simulated acid rain. Protoplasma 9 27933452
2015 The influence of nitrogen fertiliser rate and crop rotation on soil methane flux in rain-fed potato fields in Wuchuan County, China. The Science of the total environment 9 26282743
2024 Mobility, speciation of cadmium, and bacterial community composition along soil depths during microbial carbonate precipitation under simulated acid rain. Journal of environmental management 8 38271885
2020 Crop-litter type determines the structure and function of litter-decomposing microbial communities under acid rain conditions. The Science of the total environment 8 31958726
2018 Ectomycorrhizal fungi inoculation alleviates simulated acid rain effects on soil ammonia oxidizers and denitrifiers in Masson pine forest. Environmental microbiology 8 30370620
2015 Self-transport and self-alignment of microchips using microscopic rain. Scientific reports 8 26450019
1987 Acid rain: effects on arachidonic acid metabolism in perfused and ventilated guinea-pig lung. Toxicology letters 8 2823420
2023 Moderate organic fertilizer substitution for partial chemical fertilizer improved soil microbial carbon source utilization and bacterial community composition in rain-fed wheat fields: current year. Frontiers in microbiology 7 37396386
2019 Genetic analysis of drought response of wheat following either chemical desiccation or the use of a rain-out shelter. Journal of applied genetics 7 30949857
2009 Expression pattern of four storage xyloglucan mobilization-related genes during seedling development of the rain forest tree Hymenaea courbaril L. Journal of experimental botany 7 19221141

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