Affinage

RAB39B

Ras-related protein Rab-39B · UniProt Q96DA2

Length
213 aa
Mass
24.6 kDa
Annotated
2026-04-28
100 papers in source corpus 15 papers cited in narrative 15 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RAB39B is a neuron-enriched small GTPase that operates at the endoplasmic reticulum/cis-Golgi interface to regulate vesicular trafficking and macroautophagy, with dosage-sensitive roles in synaptogenesis, synaptic composition, and neuronal survival (PMID:20159109, PMID:25784538, PMID:33364235, PMID:36977207). In its GTP-bound state, RAB39B binds PICK1 to control ER-to-Golgi trafficking and surface delivery of GluA2-containing AMPARs; its loss shifts synaptic AMPAR composition toward Ca²⁺-permeable (GluA2-lacking) forms, producing immature dendritic spines and cognitive deficits rescued by the Ca²⁺-permeable AMPAR antagonist NASPM (PMID:25784538, PMID:34761259, PMID:34035473). RAB39B also interacts with class I PI3K components to suppress PI3K–AKT–mTOR signaling in neural progenitor cells, and its deletion causes NPC overproliferation, macrocephaly, and ASD-like phenotypes reversible by AKT inhibition (PMID:32115408). Loss of RAB39B impairs basal macroautophagy by reducing core ATG proteins (Atg3, Atg5, Atg7, Atg12, Atg16L1), leading to α-synuclein accumulation, ER stress, mitochondrial dysfunction, dopaminergic neuron degeneration, and Parkinson disease-like pathology in knockout mice—phenotypes partially rescued by rapamycin (PMID:36715921, PMID:40473068).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2002 Medium

    Identification of RAB39B as a novel X-linked RAB GTPase established a new member of the RAB family with unknown neuronal function.

    Evidence cDNA library sequencing and genomic characterization

    PMID:12438742

    Open questions at the time
    • no functional data
    • expression pattern not fully resolved at single-cell level
    • no effector or interaction partners identified
  2. 2010 High

    Demonstrating that RAB39B is neuron-specific and localizes to the Golgi, and that its knockdown impairs neurite growth cones and presynaptic button number, established a direct role in synapse formation.

    Evidence shRNA knockdown in cultured neurons with immunofluorescence and morphological analysis

    PMID:20159109

    Open questions at the time
    • effector proteins mediating synaptic effects unknown
    • no in vivo confirmation
    • no link to specific cargo
  3. 2015 High

    Discovery that GTP-bound RAB39B binds PICK1 and that this complex controls ER-to-Golgi trafficking and surface expression of GluA2 AMPARs resolved the molecular mechanism by which RAB39B determines synaptic AMPAR composition and Ca²⁺ permeability.

    Evidence Reciprocal co-immunoprecipitation with GTP-locked mutant, shRNA knockdown in hippocampal neurons, surface biotinylation, electrophysiology

    PMID:25784538

    Open questions at the time
    • structural basis of RAB39B–PICK1 interaction unresolved
    • whether other RAB39B effectors exist at this trafficking step unknown
    • GEF and GAP for RAB39B not identified
  4. 2014 High

    Linking RAB39B loss to dysregulated α-synuclein homeostasis in neurons opened the connection between this trafficking GTPase and Parkinson disease-relevant pathology.

    Evidence shRNA knockdown in cultured neurons with western blot and immunofluorescence for α-synuclein

    PMID:25434005

    Open questions at the time
    • mechanism linking RAB39B to α-synuclein regulation not determined at this stage
    • no in vivo PD model
    • directionality of α-synuclein change (reduced vs. accumulated) required reconciliation with later studies
  5. 2019 Medium

    Precise localization of RAB39B to the ER/cis-Golgi interface (distinct from RAB39A at late endosomes) and demonstration of its role in sphingolipid transport refined the subcellular site of action.

    Evidence Fluorescence microscopy, subcellular fractionation, fluorescent lipid analog transport assays

    PMID:30987349

    Open questions at the time
    • sphingolipid cargo specificity not fully defined
    • functional relationship between lipid transport and AMPAR trafficking not tested
    • single-lab observation
  6. 2020 High

    Identification of RAB39B interaction with class I PI3K and demonstration that its loss activates PI3K–AKT–mTOR signaling, causing NPC overproliferation and macrocephaly rescued by AKT inhibition, revealed a second major signaling axis controlled by RAB39B in neural development.

    Evidence Rab39b knockout mice, human cerebral organoids (CRISPR), co-immunoprecipitation, phospho-AKT/mTOR western blot, pharmacological rescue

    PMID:32115408

    Open questions at the time
    • whether RAB39B directly suppresses PI3K catalytic activity or acts via membrane trafficking not distinguished
    • relationship between PI3K axis and AMPAR trafficking axis not explored
    • specific PI3K subunit(s) bound not fully characterized
  7. 2020 High

    Demonstrating that Rab39b knockout mice have impaired basal autophagic flux with reduced NMDA receptor levels at postsynaptic densities, rescued by rapamycin, established autophagy as a key downstream pathway mediating RAB39B's synaptic effects.

    Evidence Rab39b knockout mice, LC3-II flux assays with bafilomycin, synaptic fractionation, behavioral testing, rapamycin rescue

    PMID:33364235

    Open questions at the time
    • how RAB39B mechanistically promotes autophagy initiation not defined
    • whether autophagy and AMPAR trafficking phenotypes are causally linked unknown
  8. 2021 High

    In vivo confirmation that RAB39B loss increases Ca²⁺-permeable AMPAR composition and produces hypermobile immature spines, rescued by NASPM, validated the PICK1–GluA2 trafficking model in intact circuits and linked it to cognitive deficits.

    Evidence Rab39b knockout mice, two-photon live imaging, electrophysiology, NASPM pharmacological rescue, behavioral testing

    PMID:34035473

    Open questions at the time
    • no structural data on RAB39B–PICK1–GluA2 complex
    • spine maturation mechanism downstream of AMPAR switch not resolved
  9. 2023 Medium

    Mechanistic dissection in dopaminergic cells showed that RAB39B deficiency reduces core ATG proteins, causing α-synuclein accumulation in ER and mitochondria with consequent ER stress and mitochondrial dysfunction; PD-associated mutants failed to rescue, linking patient mutations to autophagy failure.

    Evidence shRNA knockdown and mutant overexpression in SH-SY5Y cells, western blot for ATG proteins, ER stress and mitochondrial assays

    PMID:36715921

    Open questions at the time
    • single cell-line model
    • how RAB39B regulates ATG protein levels (transcriptional vs. post-translational) not resolved
    • no in vivo validation of mutant rescue at this point
  10. 2025 High

    Full PD modeling in Rab39b knockout mice—demonstrating dopaminergic neuron degeneration, Lewy body formation, microglial activation, NLRP3 inflammasome engagement, and motor deficits all rescued by rapamycin—consolidated the autophagy-α-synuclein axis as the primary mechanism of RAB39B-linked parkinsonism.

    Evidence Rab39b knockout mice, immunohistochemistry, western blot for autophagy/apoptosis/inflammasome markers, rapamycin pharmacological rescue, behavioral testing

    PMID:40473068

    Open questions at the time
    • GEF and GAP for RAB39B remain unidentified
    • direct molecular step by which RAB39B maintains ATG protein levels still unknown
    • whether neuroinflammatory cascade is cell-autonomous or involves non-neuronal contributions not fully dissected

Open questions

Synthesis pass · forward-looking unresolved questions
  • The GEF and GAP regulating RAB39B nucleotide cycling, the structural basis of RAB39B–PICK1 and RAB39B–PI3K interactions, and the direct molecular mechanism by which RAB39B sustains core autophagy protein levels remain unknown.
  • no GEF or GAP identified
  • no crystal or cryo-EM structure of RAB39B or its effector complexes
  • mechanistic link between ER/Golgi trafficking function and autophagy regulation not resolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003924 GTPase activity 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005783 endoplasmic reticulum 2 GO:0005794 Golgi apparatus 2
Pathway
R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-112316 Neuronal System 3 R-HSA-9612973 Autophagy 3 R-HSA-5357801 Programmed Cell Death 2 R-HSA-162582 Signal Transduction 1
Partners
GRIA2GRIA3PICK1PIK3CASNCA

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 RAB39B was identified as a novel RAB GTPase encoded on the X chromosome (Xq28), expressed in a variety of human tissues, consisting of two exons spanning 3764 bp of genomic DNA, and showing 74.2% amino acid identity with RAB39A. cDNA library sequencing and genomic analysis Cytogenetic and genome research Medium 12438742
2010 RAB39B is a neuronal-specific protein localized to the Golgi compartment; its downregulation leads to alterations in the number and morphology of neurite growth cones and a significant reduction in presynaptic buttons, indicating a role in synapse formation and maintenance. shRNA-mediated knockdown in cultured neurons, immunofluorescence localization, morphological analysis American journal of human genetics High 20159109
2014 Loss of RAB39B results in dysregulation of α-synuclein homeostasis; shRNA-mediated knockdown of Rab39b in cultured neurons reduced steady-state levels of α-synuclein and the density of α-synuclein immunoreactive puncta in dendritic processes. shRNA knockdown in cultured neurons, immunofluorescence, western blot American journal of human genetics High 25434005
2015 GTP-bound RAB39B directly interacts with PICK1 (protein interacting with C-kinase 1) as a downstream effector; the RAB39B–PICK1 complex controls trafficking from the endoplasmic reticulum to the Golgi and surface expression of the GluA2 AMPAR subunit. Downregulation of RAB39B skews AMPAR composition toward non-GluA2-containing Ca2+-permeable forms, altering synaptic activity in hippocampal neurons. Co-immunoprecipitation, pulldown with GTP-locked RAB39B mutant, shRNA knockdown in hippocampal neurons, electrophysiology, surface biotinylation Nature communications High 25784538
2015 A missense mutation (p.G192R) in the C-terminal hypervariable domain of RAB39B causes mislocalization of the mutant protein in PC12 and SK-N-BE(2)C cells, suggesting this domain mediates intracellular targeting of RAB39B. Transfection of wild-type and mutant constructs in cell lines, fluorescence microscopy Molecular neurodegeneration Medium 26399558
2019 RAB39B localizes to the secretory network at the endoplasmic reticulum/cis-Golgi interface (distinct from RAB39A which localizes to late endocytic multivesicular bodies), and controls transport of sphingolipids biosynthesized at the ER-Golgi factory. Fluorescence microscopy, subcellular fractionation, lipid transport assays using fluorescent lipid analogs and Chlamydia trachomatis as a trafficking probe International journal of molecular sciences Medium 30987349
2020 RAB39B interacts with components of Class I PI3K; its deletion activates the PI3K-AKT-mTOR signaling pathway in neural progenitor cells (NPCs), promoting NPC overproliferation and impaired differentiation, leading to macrocephaly and ASD-like behaviors. AKT inhibition rescued enlarged organoid sizes and NPC overproliferation. Rab39b knockout mice and human cerebral organoids (CRISPR), Co-immunoprecipitation for PI3K interaction, phospho-AKT/mTOR western blot, pharmacological rescue with AKT inhibitor Genes & development High 32115408
2020 RAB39B deficiency impairs autophagic flux at basal level in neurons; Rab39b knockout mice show impaired learning/memory and reduced NMDA receptors in the postsynaptic density. Rapamycin-induced autophagy activation partially rescued impaired memory and synaptic plasticity. Rab39b knockout mice, behavioral testing, autophagy flux assays (LC3-II accumulation with bafilomycin), synaptic fractionation, western blot for PSD proteins, pharmacological rescue Frontiers in cell and developmental biology High 33364235
2020 RAB39B localizes throughout cortical and hippocampal neurons and TH-positive dopaminergic neurons in the substantia nigra pars compacta in mice throughout postnatal life; it is enriched in MAP2-positive neurons. In situ hybridization, immunohistochemistry with novel monoclonal antibodies and Rab39b knockout controls, western blot on brain lysates Molecular brain High 32228644
2020 RAB39B co-localizes with beta-amyloid plaques in post-mortem human brain tissue from DLB and AD cases, and is present in a subpopulation of Lewy bodies in DLB. Subcellular fractionation revealed reduced cytoplasmic RAB39B in DLB, indicating sequestration of RAB39B into pathological aggregates impairs its normal vesicular trafficking function. Immunohistochemistry on tissue microarrays from post-mortem brains, subcellular fractionation, western blot Brain pathology Medium 32762091
2021 RAB39B controls GluA2/GluA3 AMPAR trafficking and dendritic spine refinement; loss of RAB39B in knockout mice results in increased Ca2+-permeable AMPAR composition, hypermobile immature spines, and cognitive/behavioral alterations. The Ca2+-permeable AMPAR antagonist NASPM restored spine hypermobility. Rab39b knockout mice, two-photon live imaging of spine dynamics, electrophysiology, NASPM pharmacological rescue, behavioral testing Molecular psychiatry High 34035473
2023 RAB39B deficiency impairs macroautophagy (reducing Atg3, Atg5, Atg7, Atg12, Atg16L1), which leads to accumulation of α-synuclein in the ER and mitochondria of SH-SY5Y dopaminergic cells, activating ER stress pro-apoptotic cascades, mitochondrial dysfunction, and oxidative stress. PD-associated mutant RAB39B (T168K, W186X, G192R) failed to prevent these effects. shRNA knockdown and mutant overexpression in SH-SY5Y cells, western blot for autophagy markers and α-synuclein, mitochondrial membrane potential assay, ER stress markers, apoptosis assays Molecular neurobiology Medium 36715921
2022 A RAB39B nonstop mutation causes protein instability and increased degradation. In a Rab39b knockdown mouse model, downregulation of RAB39B increases Ca2+-permeable (GluA2-lacking) AMPAR composition at hippocampal neuronal surfaces and increases dendritic spine density in an immature filopodia-like state, affecting social behavior and memory. Heterologous cell expression of nonstop mutant, western blot for protein stability, Rab39b KD mouse model, surface biotinylation of AMPARs, Golgi staining for spine morphology, behavioral testing Human molecular genetics High 34761259
2023 Neuronal overexpression of RAB39B decreases dendritic arborization of primary neurons in vitro, reduces synaptic transmission, impairs recognition and working memory, and alters autophagy in mice, demonstrating that both loss and gain of RAB39B function are detrimental to neuronal development. AAV-mediated overexpression in neonatal mouse brain, primary neuron morphology analysis, electrophysiology, autophagy assays, behavioral testing Journal of cellular and molecular medicine Medium 36977207
2025 Rab39b knockout mice develop PD motor impairment, degeneration of substantia nigra dopaminergic neurons, and Lewy bodies. RAB39B deficiency impairs macroautophagy via reduction of autophagy proteins (Atg3, Atg5, Atg7, Atg12, Atg16L1), elevating α-synuclein and activating ER stress apoptotic signaling, mitochondrial dysfunction, microglial activation, NLRP3 inflammasome, and necroptotic pathways. Rapamycin reversed autophagy dysfunction, reduced α-synuclein, and ameliorated motor deficits. Rab39b knockout mice, western blot for autophagy and apoptosis markers, immunohistochemistry for dopaminergic neurons and α-synuclein, rapamycin pharmacological rescue, behavioral testing Life sciences High 40473068

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with α-synuclein pathology. American journal of human genetics 202 25434005
2010 Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly. American journal of human genetics 198 20159109
1993 Glycosylation of neuraminidase determines the neurovirulence of influenza A/WSN/33 virus. Journal of virology 131 8411368
2020 Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes. Genes & development 121 32115408
1975 Temperature-sensitive mutants of influenza WSN virus defective in virus-specific RNA synthesis. Journal of virology 114 1165595
1990 Function of two discrete regions is required for nuclear localization of polymerase basic protein 1 of A/WSN/33 influenza virus (H1 N1). Molecular and cellular biology 113 2196448
1991 Two signals mediate nuclear localization of influenza virus (A/WSN/33) polymerase basic protein 2. Journal of virology 111 1985200
2015 The RAB39B p.G192R mutation causes X-linked dominant Parkinson's disease. Molecular neurodegeneration 87 26399558
2015 The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition. Nature communications 78 25784538
2015 Loss-of-function mutations in RAB39B are associated with typical early-onset Parkinson disease. Neurology. Genetics 77 27066548
1982 Complete nucleotide sequence of the neuraminidase gene of human influenza virus A/WSN/33. Journal of virology 75 7077751
2002 Persistence of viral RNA in the brain of offspring to mice infected with influenza A/WSN/33 virus during pregnancy. Journal of neurovirology 57 12161820
2003 Invasion and persistence of the neuroadapted influenza virus A/WSN/33 in the mouse olfactory system. Viral immunology 48 14583155
1992 Nuclear retention of M1 protein in a temperature-sensitive mutant of influenza (A/WSN/33) virus does not affect nuclear export of viral ribonucleoproteins. Journal of virology 44 1527844
2014 Activation of A1-adenosine receptors promotes leukocyte recruitment to the lung and attenuates acute lung injury in mice infected with influenza A/WSN/33 (H1N1) virus. Journal of virology 42 24965449
2016 A novel RAB39B gene mutation in X-linked juvenile parkinsonism with basal ganglia calcification. Movement disorders : official journal of the Movement Disorder Society 41 27943471
2019 Metabolomic Analysis of Influenza A Virus A/WSN/1933 (H1N1) Infected A549 Cells during First Cycle of Viral Replication. Viruses 40 31683654
1994 Abortive replication of influenza virus A/WSN/33 in HeLa229 cells: defective viral entry and budding processes. Virology 40 7941316
2017 Mutations in RAB39B in individuals with intellectual disability, autism spectrum disorder, and macrocephaly. Molecular autism 35 29152164
2015 Genetic analysis of the RAB39B gene in Chinese Han patients with Parkinson's disease. Neurobiology of aging 35 26163985
1983 The sequence of RNA segment 1 of influenza virus A/NT/60/68 and its comparison with the corresponding segment of strains A/PR/8/34 and A/WSN/33. Nucleic acids research 35 6828387
1982 Complete nucleotide sequence of the polymerase 3 gene of human influenza virus A/WSN/33. Journal of virology 35 7045393
1982 Sequence analysis of the polymerase 1 gene and the secondary structure prediction of polymerase 1 protein of human influenza virus A/WSN/33. Journal of virology 35 7143569
1985 Influenza viral (A/WSN/33) hemagglutinin is expressed and glycosylated in the yeast Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America 34 2580304
1998 A novel spliced transcript of influenza A/WSN/33 virus. Virus genes 33 9857991
1994 Analysis of the signals for polarized transport of influenza virus (A/WSN/33) neuraminidase and human transferrin receptor, type II transmembrane proteins. Journal of virology 32 8107243
2002 Isolation and characterization of a human novel RAB (RAB39B) gene. Cytogenetic and genome research 31 12438742
2020 RAB39B Deficiency Impairs Learning and Memory Partially Through Compromising Autophagy. Frontiers in cell and developmental biology 30 33364235
2017 X-linked Parkinsonism with Intellectual Disability caused by novel mutations and somatic mosaicism in RAB39B gene. Parkinsonism & related disorders 29 28851564
1995 Characterization of putative defective interfering (DI) A/WSN RNAs isolated from the lungs of mice protected from an otherwise lethal respiratory infection with influenza virus A/WSN (H1N1): a subset of the inoculum DI RNAs. Virology 29 7793084
1988 Nucleotide sequence of RNA segment 7 and the predicted amino sequence of M1 and M2 proteins of FPV/Weybridge (H7N7) and WSN (H1N1) influenza viruses. Virus research 27 3414185
2015 Infection of mice with influenza A/WSN/33 (H1N1) virus alters alveolar type II cell phenotype. American journal of physiology. Lung cellular and molecular physiology 26 25595651
2008 The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit. The Journal of general virology 26 19008377
2001 Persistence of the influenza A/WSN/33 virus RNA at midbrain levels of immunodefective mice. Journal of neurovirology 25 11517384
1982 Proteolytic activation of influenza WSN virus in cultured cells is performed by homologous plasma enzymes. The Journal of general virology 25 6218257
2019 Rab39a and Rab39b Display Different Intracellular Distribution and Function in Sphingolipids and Phospholipids Transport. International journal of molecular sciences 24 30987349
1977 Characterization of cytoplasmic inclusions formed during influenza/WSN virus infection of chick embryo fibroblast cells. Intervirology 23 885697
2014 The temperature-sensitive and attenuation phenotypes conferred by mutations in the influenza virus PB2, PB1, and NP genes are influenced by the species of origin of the PB2 gene in reassortant viruses derived from influenza A/California/07/2009 and A/WSN/33 viruses. Journal of virology 22 25122786
2020 RAB39B's role in membrane traffic, autophagy, and associated neuropathology. Journal of cellular physiology 21 32761840
1980 Construction and characterization of a bacterial clone containing the hemagglutinin gene of the WSN strain (HON1) of influenza virus. Gene 21 6254839
2021 Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases. Movement disorders : official journal of the Movement Disorder Society 20 33939203
2016 RAB39B gene mutations are not a common cause of Parkinson's disease or dementia with Lewy bodies. Neurobiology of aging 20 27459931
2020 Clinical and Neuropathological Features Associated With Loss of RAB39B. Movement disorders : official journal of the Movement Disorder Society 19 31951675
1993 Persistence of viral genes in a variant of MDBK cell after productive replication of a mutant of influenza virus A/WSN. Archives of virology 19 8418792
2005 Attenuating mutations of the matrix gene of influenza A/WSN/33 virus. Journal of virology 18 15650216
2004 Introduction of a temperature-sensitive phenotype into influenza A/WSN/33 virus by altering the basic amino acid domain of influenza virus matrix protein. Journal of virology 18 15331690
1989 Effects of cell differentiation on replication of A/WS/33, WSN, and A/PR/8/34 influenza viruses in mouse brain cell cultures: biological and immunological characterization of products. Journal of virology 18 2648025
2021 RAB39B-mediated trafficking of the GluA2-AMPAR subunit controls dendritic spine maturation and intellectual disability-related behaviour. Molecular psychiatry 17 34035473
1986 Identification of the defects in the hemagglutinin gene of two temperature-sensitive mutants of A/WSN/33 influenza virus. Virology 17 3765394
2015 The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice. The Journal of general virology 16 25934792
2010 Prophylactic activity of intramuscular peramivir in mice infected with a recombinant influenza A/WSN/33 (H1N1) virus containing the H274Y neuraminidase mutation. Antimicrobial agents and chemotherapy 16 20404128
1990 Characterization of a temperature-sensitive mutant in the RNA polymerase PB2 subunit gene of influenza A/WSN/33 virus. Archives of virology 15 2222191
2012 Therapeutic activity of intramuscular peramivir in mice infected with a recombinant influenza A/WSN/33 (H1N1) virus containing the H275Y neuraminidase mutation. Antimicrobial agents and chemotherapy 14 22664977
1989 Role of hemagglutinin cleavage and expression of M1 protein in replication of A/WS/33, A/PR/8/34, and WSN influenza viruses in mouse brain. Journal of virology 14 2648024
1988 Transient expression and sequence of the matrix (M1) gene of WSN influenza A virus in a vaccinia vector. Virology 14 3354209
1986 Identification of defects in the neuraminidase gene of four temperature-sensitive mutants of A/WSN/33 influenza virus. Virology 14 3750846
1990 Inhibition of influenza virus A/WSN replication by a trypsin inhibitor, 6-amidino-2-naphthyl p-guanidinobenzoate. Biochemical and biophysical research communications 13 2350338
1984 Mechanism of interference between influenza A/WSN and B/Kanagawa viruses. The Journal of general virology 13 6747607
1976 Temperature-sensitive virion transcriptase activity in mutants of WSN influenza virus. Archives of virology 13 999515
2020 RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies. Brain pathology (Zurich, Switzerland) 12 32762091
2023 Deficiency of RAB39B Activates ER Stress-Induced Pro-apoptotic Pathway and Causes Mitochondrial Dysfunction and Oxidative Stress in Dopaminergic Neurons by Impairing Autophagy and Upregulating α-Synuclein. Molecular neurobiology 11 36715921
2000 Mapping to distal Xq28 of nonspecific X-linked mental retardation MRX72: linkage analysis and clinical findings in a three-generation Sardinian family. American journal of medical genetics 11 11050621
1993 MDBK cells which survived infection with a mutant of influenza virus A/WSN and subsequently received many passages contained viral M and NS genes in full length in the absence of virus production. Archives of virology 11 8517796
2020 Distribution of Parkinson's disease associated RAB39B in mouse brain tissue. Molecular brain 10 32228644
2020 Genetic Analysis of RAB39B in an Early-Onset Parkinson's Disease Cohort. Frontiers in neurology 10 32670181
2019 MDCK-B4GalNT2 cells disclose a α2,3-sialic acid requirement for the 2009 pandemic H1N1 A/California/04/2009 and NA aid entry of A/WSN/33. Emerging microbes & infections 10 31560252
2016 RAB39B gene mutations are not linked to familial Parkinson's disease in China. Scientific reports 10 27694831
2022 Research on Coverage Optimization in a WSN Based on an Improved COOT Bird Algorithm. Sensors (Basel, Switzerland) 9 35591071
2020 A novel RAB39B mutation and concurrent de novo NF1 mutation in a boy with neurofibromatosis type 1, intellectual disability, and autism: a case report. BMC neurology 9 32873259
2012 The compensatory G88R change is essential in restoring the normal functions of influenza A/WSN/33 virus matrix protein 1 with a disrupted nuclear localization signal. Journal of virology 9 23077315
2022 RAB39B as a Chemosensitivity-Related Biomarker for Diffuse Large B-Cell Lymphoma. Frontiers in pharmacology 8 35910358
2018 An Effective Hybrid Routing Algorithm in WSN: Ant Colony Optimization in combination with Hop Count Minimization. Sensors (Basel, Switzerland) 8 29596336
2017 Generation of induced pluripotent stem cell line (ZZUi005-A) from a 21-year-old patient with a novel RAB39B gene mutation in X-linked juvenile parkinsonism. Stem cell research 8 29128816
2016 Lack of RAB39B mutations in early-onset and familial Parkinson's disease in a Taiwanese cohort. Neurobiology of aging 8 27838047
1995 Non-sialate inhibitor of influenza A/WSN/33 neuraminidase. Biochemistry 8 7539292
1994 Use of competitive PCR to estimate the level of NS gene persisting in MDCK cells which survived productive replication of a mutant of influenza virus A/WSN. Journal of virological methods 8 7868652
2023 Increased level of RAB39B leads to neuronal dysfunction and behavioural changes in mice. Journal of cellular and molecular medicine 7 36977207
2018 Generation of RAB39B knockout isogenic human embryonic stem cell lines to model RAB39B-mediated Parkinson's disease. Stem cell research 7 29499499
2013 An Influenza Virus M2 Protein Specific Chimeric Antigen Receptor Modulates Influenza A/WSN/33 H1N1 Infection In Vivo. The open virology journal 7 23493233
2022 Clinical characterization of a novel RAB39B nonstop mutation in a family with ASD and severe ID causing RAB39B downregulation and study of a Rab39b knock down mouse model. Human molecular genetics 6 34761259
2015 [Inhibition of replication and transcription of WSN influenza A virus by IFIT family genes]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 4 26021086
2024 Novel RAB39B loss-of-function mutation in patient with typical early-onset Parkinson's disease. Parkinsonism & related disorders 3 38503262
2024 Energy efficient cluster-based routing protocol for WSN using multi-strategy fusion snake optimizer and minimum spanning tree. Scientific reports 3 39039083
2023 Loss of RAB39B does not alter MPTP-induced Parkinson's disease-like phenotypes in mice. Frontiers in aging neuroscience 3 36761179
2022 Multimodal imaging of a patient with RAB39B mutation. Neuroradiology 3 35088096
2022 Knockdown of FLT4, Nup98, and Nup205 Cellular Genes Effectively Suppresses the Reproduction of Influenza Virus Strain A/WSN/1933 (H1N1) In vitro. Infectious disorders drug targets 3 35339191
2020 Filamentous versus Spherical Morphology: A Case Study of the Recombinant A/WSN/33 (H1N1) Virus. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 3 32036809
2025 Two case reports of RAB39B deletion displaying highly variable parkinsonism. Parkinsonism & related disorders 2 40245817
2025 Absence of Rab39b-induced macroautophagy impairment increases neurotoxic α-synuclein and causes degeneration of substantia nigra dopaminergic neurons in mouse model of X-linked Parkinson's disease. Life sciences 2 40473068
2023 Novel RAB39B variant associated intellectual disability and levodopa-responsive young-onset parkinsonism. Parkinsonism & related disorders 2 37844350
2021 Generation of induced pluripotent stem cell line (ZZUi027-A) derived from skin fibroblasts from a Parkinson's disease patient with RAB39B gene mutation. Stem cell research 2 34247111
2019 LCSS-Based Algorithm for Computing Multivariate Data Set Similarity: A Case Study of Real-Time WSN Data. Sensors (Basel, Switzerland) 2 30621241
2018 Pre-exposure with influenza A virus A/WSN/1933(H1N1) resulted in viral shedding reduction from pigs challenged with either swine H1N1 or H3N2 virus. Veterinary microbiology 2 30593376
2014 Based on regular expression matching of evaluation of the task performance in WSN: a queue theory approach. TheScientificWorldJournal 2 25401151
2024 Expression of human Ras-related protein Rab39B variant T168K in Caenorhabditis elegans leads to motor dysfunction and dopaminergic neuron degeneration. Heliyon 1 38444482
2023 Influenza A virus strain PR/8/34, but neither HAM/2009 nor WSN/33, is transiently inhibited by the PB2-targeting drug paliperidone. Archives of virology 1 36637551
2022 Prenatal diagnosis of de novo int22h1/int22h2-mediated Xq28 duplication syndrome involving RAB39B following a previous ambiguous genitalia pregnancy. Taiwanese journal of obstetrics & gynecology 1 35595445
1988 Selective inhibition of WSN influenza virus haemolysis by pea lectin. The Journal of general virology 1 2832534
1975 Morphology of A/WSN influenza virus-infected chick embryo cells. Acta virologica 1 239562
2025 RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation. Open medicine (Warsaw, Poland) 0 40177653