Affinage

QPCT

Glutaminyl-peptide cyclotransferase · UniProt Q16769

Length
361 aa
Mass
40.9 kDa
Annotated
2026-06-10
100 papers in source corpus 9 papers cited in narrative 9 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

QPCT is a glutaminyl cyclase that catalyzes the conversion of N-terminal glutaminyl residues into pyroglutamate (pGlu) on substrate peptides, including peptide hormones, neuropeptides, chemokines, and amyloid peptides (PMID:24886834). Catalysis proceeds through an intermediate structurally resembling L-proline, with substrate binding — particularly the identity of the second N-terminal residue — serving as the principal specificity-determining step (PMID:8839986). Active-site residues F325, I303, and S323 govern enzyme-inhibitor interactions, with F325 and I303 substitutions sharply reducing potency of the inhibitor PBD150 (PMID:22967026). Beyond its canonical catalytic role, QPCT acts as a writer of a CD47 post-translational modification on senescent cells that stabilizes CD47 and suppresses macrophage efferocytosis via the SIRPα-CD47-SHP-1 axis (PMID:36459066), and QPCT inhibition reduces aggregation of mutant huntingtin and other aggregation-prone proteins by inducing the chaperone αB-crystallin (PMID:25848931). In renal cell carcinoma, QPCT binds HRAS directly, attenuates its ubiquitination to stabilize the protein, and activates ERK signaling, with QPCT transcription driven by NF-κB (p65) (PMID:31534544). QPCT additionally functions in cancer cell phenotypes including sunitinib resistance and myeloid differentiation (PMID:34036385, PMID:37381175).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1996 Medium

    Established the core catalytic activity and specificity logic of glutaminyl cyclase, defining how the enzyme selects and converts N-terminal glutaminyl peptides.

    Evidence In vitro enzyme kinetics with systematic substrate and inhibitor panels using papaya latex QC

    PMID:8839986

    Open questions at the time
    • Single study on a non-human (papaya) ortholog
    • Physiological human substrates not defined here
    • No structural model of the active site
  2. 2012 Medium

    Defined the human QC active-site residues responsible for inhibitor binding, providing the molecular basis for rational inhibitor design.

    Evidence Site-directed mutagenesis of human QC with inhibitor potency readouts and semi-empirical QC/MM calculations

    PMID:22967026

    Open questions at the time
    • Residue roles defined for inhibitor PBD150, not for natural substrates
    • No co-crystal structure
    • Single lab
  3. 2014 Medium

    Mapped QPCT/isoQC enzymatic activity across brain regions and tied the enzyme to pGlu modification of hormones, neuropeptides, chemokines, and pathogenic amyloid peptides.

    Evidence Enzymatic activity assays and immunohistochemistry across nine mouse strains and brain regions

    PMID:24886834

    Open questions at the time
    • Does not separate QPCT from isoQC contributions in all regions functionally
    • Causal link to neurodegeneration not tested here
    • Human brain not assessed
  4. 2015 High

    Connected QPCT activity to protein aggregation pathology, showing that inhibiting QPCT suppresses mutant huntingtin toxicity via chaperone induction.

    Evidence siRNA screen in human cells with genetic validation in Drosophila and zebrafish HD models, plus in silico inhibitor design

    PMID:25848931

    Open questions at the time
    • Mechanistic link between QC catalysis and αB-crystallin induction not fully resolved
    • Direct QPCT substrate driving the effect not identified
    • Effect in mammalian HD disease models not shown
  5. 2015 Medium

    Revealed genomic imprinting and epigenetic control of Qpct, indicating dosage-sensitive developmental regulation distinct from its enzymatic function.

    Evidence Allele-specific expression analysis and ChIP for H3K4me3 with developmental expression profiling in mice

    PMID:26447138

    Open questions at the time
    • Functional consequence of imprinting for QPCT activity unknown
    • Mouse-specific; human conservation untested
    • No link to enzymatic phenotypes
  6. 2019 Medium

    Identified a non-enzymatic protein-stabilizing role for QPCT in cancer, where direct HRAS binding attenuates ubiquitination to drive ERK signaling, plus its NF-κB-driven transcriptional control.

    Evidence Proteome microarray, reciprocal Co-IP, ubiquitination assay, ChIP, and knockdown/overexpression with ERK readout in RCC cells

    PMID:31534544

    Open questions at the time
    • Whether HRAS stabilization requires QC catalytic activity is unresolved
    • Single lab
    • Direct ubiquitination mechanism not fully reconstituted
  7. 2021 Low

    Extended QPCT's oncogenic role to sunitinib resistance via a CTCF-QPCT-PIK3CA angiogenic axis in RCC.

    Evidence Analysis of sunitinib-resistant vs. -responsive RCC tissues and plasma with pathway analysis

    PMID:34036385

    Open questions at the time
    • CTCF-QPCT binding and PIK3CA activation not mechanistically reconstituted
    • Pathway inferred from tissue correlation
    • Single lab
  8. 2022 Medium

    Established QPCT/L as a writer of a CD47 modification that controls innate immune recognition of senescent cells through the SIRPα-CD47-SHP-1 axis.

    Evidence Direct contact efferocytosis assays with QPCT/L inhibition and pathway interference in senescent cell models in vitro and in vivo

    PMID:36459066

    Open questions at the time
    • The CD47 modification itself was not reconstituted in vitro
    • Direct identification of the modified residue/pGlu mark not shown
    • Single lab
  9. 2023 Low

    Implicated QPCT in myeloid differentiation and as a downstream effector of an HDAC inhibitor's anti-leukemic action.

    Evidence QPCT knockdown/overexpression and rescue in AML cell lines with Apicidin treatment and proliferation/apoptosis/differentiation assays

    PMID:37381175

    Open questions at the time
    • No molecular mechanism for how QPCT mediates these effects
    • Whether catalytic activity is required is untested
    • Single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • Whether QPCT's diverse non-canonical roles (CD47 modification, HRAS stabilization, huntingtin aggregation, leukemic differentiation) all depend on its glutaminyl cyclase catalytic activity, and the identity of the relevant physiological substrates, remains unresolved.
  • No direct demonstration that catalysis underlies the CD47 or HRAS effects
  • Endogenous human substrates largely undefined
  • No structural model linking active site to specific peptide targets

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 2 GO:0016853 isomerase activity 1 GO:0140096 catalytic activity, acting on a protein 1
Pathway
R-HSA-392499 Metabolism of proteins 2 R-HSA-162582 Signal Transduction 1 R-HSA-168256 Immune System 1
Partners
HRAS

Evidence

Reading pass · 9 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2022 QPCT/L (glutaminyl cyclase) enzymes modify CD47 on senescent cells, increasing CD47 stability/activity, which suppresses macrophage-mediated efferocytosis (clearance of apoptotic corpses) through the SIRPα-CD47-SHP-1 signaling axis. Senescent cell-mediated efferocytosis suppression (SCES) was reversible by interfering with QPCT/L activity, establishing QPCT as a writer of a CD47 post-translational modification that regulates innate immune recognition. Direct contact assays, QPCT/L inhibition, SIRPα-CD47-SHP-1 pathway interference, in vitro and in vivo senescent cell models The Journal of cell biology Medium 36459066
2015 QPCT inhibition reduces mutant huntingtin (HTT) aggregation and toxicity by inducing upregulation of the molecular chaperone αB-crystallin, and this mechanism also reduces aggregation of diverse proteins. New QPCT inhibitors generated by in silico methods and in vitro screening rescued HD-related phenotypes in cell, Drosophila, and zebrafish models. siRNA screen in human cells, Drosophila genetic validation, zebrafish HD models, αB-crystallin induction assays, in silico inhibitor design followed by in vitro screening Nature chemical biology High 25848931
2019 QPCT binds directly to HRAS and attenuates HRAS ubiquitination, thereby increasing HRAS protein stability and leading to activation of the ERK pathway in renal cell carcinoma cells. NF-κB (p65) positively regulates QPCT transcription by binding to the QPCT promoter, and this binding is blocked by promoter hypermethylation. Human proteome microarray to identify QPCT-interacting proteins, co-immunoprecipitation, confocal laser microscopy, ChIP assay, ubiquitination assay, QPCT knockdown/overexpression with ERK pathway readout Theranostics Medium 31534544
1996 Glutamine cyclotransferase (QC, QPCT) catalyzes pyroglutamate formation from N-terminal glutaminyl residues in peptides. The second amino acid residue in N-terminal glutaminyl peptides significantly accelerates the reaction, while the third residue provides no further rate enhancement. Substrate binding is the main specificity-determining step. Proline derivatives and N-terminal proline-containing dipeptides inhibit QC activity, consistent with a reaction mechanism involving intermediates structurally similar to L-proline. In vitro enzyme kinetics with systematic substrate and inhibitor specificity testing using papaya latex QC Biological chemistry Hoppe-Seyler Medium 8839986
2012 Site-directed mutagenesis of human QC (QPCT) at residues F325, I303, and S323 defined key interactions between the enzyme and the inhibitor PBD150 in solution: replacement of F325 or I303 with alanine/asparagine caused ~800-fold reduction in inhibitor potency, while replacement of S323 with alanine or valine caused ~20-fold increased inhibitor activity, establishing these residues as critical for the enzyme-inhibitor binding site. Site-directed mutagenesis of human QC, in vitro enzyme-inhibitor activity assays, semi-empirical QC/MM calculations Chemical biology & drug design Medium 22967026
2014 QC (QPCT) and its isoenzyme isoQC are expressed throughout the mouse brain with region-specific and strain-specific patterns. Enzymatic QC/isoQC activity is highest in ventral brain, followed by cortex and hippocampus. In cortex, activity arises predominantly from isoQC expression. Both enzymes catalyze pyroglutamate formation from glutamine precursors at the N-terminus of peptide hormones, neuropeptides, and chemokines, and QC is also involved in pathogenic pGlu modification of amyloid peptides in neurodegeneration. Enzymatic activity assays and immunohistochemistry with specific antibodies across nine mouse strains and multiple brain regions; unbiased stereology for cell counting International journal of developmental neuroscience Medium 24886834
2015 Qpct is a maternally imprinted gene in mice (expressed from the maternal allele only in placenta). ChIP assay demonstrated that histone H3K4me3 modification is associated with maternal activation of Qpct expression. Qpct is expressed during early embryonic development in brain regions and shows peak expression in the labyrinth layer of the placenta at E15.5. Allele-specific expression analysis, ChIP assay for H3K4me3, in situ hybridization/expression profiling across developmental stages Molecules and cells Medium 26447138
2021 QPCT expression is regulated by CCCTC-binding factor (CTCF) and promotes sunitinib resistance in renal cell carcinoma by promoting angiogenesis, with PIK3CA identified as a downstream effector. This extends the previously reported QPCT-HRAS-ERK axis for sunitinib resistance. Analysis of sunitinib-resistant vs. -responsive RCC tissues and plasma, molecular pathway analysis of CTCF-QPCT-PIK3CA axis International journal of oncology Low 34036385
2023 QPCT knockdown in acute myeloid leukemia (AML) cells promotes cell proliferation, inhibits apoptosis, and impairs myeloid differentiation, while QPCT upregulation by the HDAC inhibitor Apicidin mediates anti-leukemic effects. Rescue assay confirmed that QPCT depletion alleviates Apicidin's anti-leukemic effects, placing QPCT downstream of Apicidin in this pathway. QPCT knockdown/overexpression in AML cell lines, Apicidin treatment, proliferation/apoptosis/differentiation assays, rescue experiments Cancer biology & therapy Low 37381175

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 mito-QC illuminates mitophagy and mitochondrial architecture in vivo. The Journal of cell biology 427 27458135
1997 Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behçet disease. Proceedings of the National Academy of Sciences of the United States of America 338 9037047
2017 Outcome of patients with intracranial non-germinomatous germ cell tumors-lessons from the SIOP-CNS-GCT-96 trial. Neuro-oncology 163 29048505
1993 Relationship between parental trinucleotide GCT repeat length and severity of myotonic dystrophy in offspring. JAMA 163 8464127
1994 The granular convoluted tubule (GCT) cell of rodent submandibular glands. Microscopy research and technique 152 8155902
1992 Anticipation in myotonic dystrophy. II. Complex relationships between clinical findings and structure of the GCT repeat. Neurology 134 1407566
1980 The fractionation, characterization, and subcellular localization of colony-stimulating activities released by the human monocyte-like cell line, GCT. Blood 92 6968234
2011 OsIAA23-mediated auxin signaling defines postembryonic maintenance of QC in rice. The Plant journal : for cell and molecular biology 89 21736653
2000 Solution structure of an LNA hybridized to DNA: NMR study of the d(CT(L)GCT(L)T(L)CT(L)GC):d(GCAGAAGCAG) duplex containing four locked nucleotides. Bioconjugate chemistry 88 10725100
2022 Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis. The Journal of cell biology 85 36459066
2004 QA/QC: challenges and pitfalls facing the microarray community and regulatory agencies. Expert review of molecular diagnostics 78 15525219
2015 siRNA screen identifies QPCT as a druggable target for Huntington's disease. Nature chemical biology 74 25848931
1997 Benign giant cell tumor of bone with osteosarcomatous transformation ("dedifferentiated" primary malignant GCT): report of two cases. Skeletal radiology 71 9151375
2021 Mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-QC. Autophagy 62 33685343
1981 Hydrophobic adsorption chromatography of colony-stimulating activities and erythroid-enhancing activity from the human monocyte-like cell line, GCT. Blood 51 6975643
2021 2020 White Paper on Recent Issues in Bioanalysis: Vaccine Assay Validation, qPCR Assay Validation, QC for CAR-T Flow Cytometry, NAb Assay Harmonization and ELISpot Validation (Part 3 - Recommendations on Immunogenicity Assay Strategies, NAb Assays, Biosimilars and FDA/EMA Immunogenicity Guidance/Guideline, Gene & Cell Therapy and Vaccine Assays). Bioanalysis 49 33533276
2013 QC-Chain: fast and holistic quality control method for next-generation sequencing data. PloS one 49 23565205
2016 Histologic Spectrum of Giant Cell Tumor (GCT) of Bone in Patients 18 Years of Age and Below: A Study of 63 Patients. The American journal of surgical pathology 47 27526293
2019 DNA methylation-regulated QPCT promotes sunitinib resistance by increasing HRAS stability in renal cell carcinoma. Theranostics 46 31534544
2012 Transforming growth factor alpha (TGFα) regulates granulosa cell tumor (GCT) cell proliferation and migration through activation of multiple pathways. PloS one 45 23155381
2018 RNA-QC-chain: comprehensive and fast quality control for RNA-Seq data. BMC genomics 44 29444661
2014 Combining gemcitabine, cisplatin, and ifosfamide (GIP) is active in patients with relapsed metastatic germ-cell tumors (GCT): a prospective multicenter GETUG phase II trial. Annals of oncology : official journal of the European Society for Medical Oncology 43 24595454
1998 UKCCSG's germ cell tumour (GCT) studies: improving outcome for children with malignant extracranial non-gonadal tumours--carboplatin, etoposide, and bleomycin are effective and less toxic than previous regimens. United Kingdom Children's Cancer Study Group. Medical and pediatric oncology 41 9473756
2004 Association of multiple nucleotide variations in the pituitary glutaminyl cyclase gene (QPCT) with low radial BMD in adult women. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 38 15231017
2002 A new allele within the transmembrane region of the human MICA gene with seven GCT repeats. Tissue antigens 33 12542746
1995 Assessment of antiretroviral therapy by plasma viral load testing: standard and ICD HIV-1 p24 antigen and viral RNA (QC-PCR) assays compared. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 33 7552477
2016 Winner of the Young Investigator Award of the Society for Biomaterials at the 10th World Biomaterials Congress, May 17-22, 2016, Montreal QC, Canada: Microribbon-based hydrogels accelerate stem cell-based bone regeneration in a mouse critical-size cranial defect model. Journal of biomedical materials research. Part A 32 26991141
2019 Monitoring polysorbate hydrolysis in biopharmaceuticals using a QC-ready free fatty acid quantification method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 29 30951966
2011 Serum vascular endothelial growth factor A (VEGF) is elevated in patients with ovarian granulosa cell tumor (GCT), and VEGF inhibition by bevacizumab induces apoptosis in GCT in vitro. The Journal of clinical endocrinology and metabolism 29 21994955
2010 FN1, GALE, MET, and QPCT overexpression in papillary thyroid carcinoma: molecular analysis using frozen tissue and routine fine-needle aspiration biopsy samples. Diagnostic cytopathology 28 20607686
2013 Adult granulosa cell tumours (GCT): clinicopathological outcomes including FOXL2 mutational status and expression. Gynecologic oncology 27 24007948
2013 Catalytic mechanism of the glycyl radical enzyme 4-hydroxyphenylacetate decarboxylase from continuum electrostatic and QC/MM calculations. Journal of the American Chemical Society 27 24028464
2009 Cisplatin and etoposide in childhood germ cell tumor: brazilian pediatric oncology society protocol GCT-91. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27 19164215
2001 Quantitative competitive (QC) PCR for quantification of porcine DNA. Meat science 27 22061359
2022 Phase II study of Disulfiram and Cisplatin in Refractory Germ Cell Tumors. The GCT-SK-006 phase II trial. Investigational new drugs 25 35763178
2020 The mito-QC Reporter for Quantitative Mitophagy Assessment in Primary Retinal Ganglion Cells and Experimental Glaucoma Models. International journal of molecular sciences 25 32164182
1990 Electron nuclear double resonance (ENDOR) of the Qc.- ubisemiquinone radical in the mitochondrial electron transport chain. Biochemistry 25 2171637
2012 Molecular interactions of the quinone electron acceptors Q(A), Q(B), and Q(C) in photosystem II as studied by the fragment molecular orbital method. Photosynthesis research 24 23208472
2013 Free analyte QC concept: a novel approach to prove correct quantification of free therapeutic protein drug/biomarker concentrations. Bioanalysis 22 24279646
2007 Four thiol peroxidases contain a conserved GCT catalytic motif and act as a versatile array of lipid peroxidases in Anabaena sp. PCC7120. Free radical biology & medicine 22 17462542
1995 Band 4.2 Shiga: 317 CGC-->TGC in compound heterozygotes with 142 GCT-->ACT results in band 4.2 deficiency and microspherocytosis. British journal of haematology 22 8547071
2016 Lowered Cisplatin Dose and No Bleomycin in the Treatment of Pediatric Germ Cell Tumors: Results of the GCT-99 Protocol From the Brazilian Germ Cell Pediatric Oncology Cooperative Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19 26729441
2011 Management of localized seminoma, stage I-II: SIU/ICUD Consensus Meeting on Germ Cell Tumors (GCT), Shanghai 2009. Urology 18 21986223
2009 Measurement of signs of chemical shift differences between ground and excited protein states: a comparison between H(S/M)QC and R1rho methods. Journal of biomolecular NMR 18 20033258
1993 Phenotypic characterization of the human fibrous histiocytoma giant cell tumor (GCT) cell line and its cytokine repertoire. Experimental hematology 18 7689482
1980 Erythropoietic enhancing activity (EEA) secreted by the human cell line, GCT. Journal of supramolecular structure 18 6972469
2014 Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 17 24886834
1988 Gene for ovarian granulosa cell tumor susceptibility, Gct, in SWXJ recombinant inbred strains of mice revealed by dehydroepiandrosterone. Cancer research 17 2970296
2021 Gemcitabine, carboplatin and veliparib in multiple relapsed/refractory germ cell tumours: The GCT-SK-004 phase II trial. Investigational new drugs 16 34052929
1994 Electron microscopic and physicobiochemical studies on disorganization of the cytoskeletal network and integral protein (band 3) in red cells of band 4.2 deficiency with a mutation (codon 142: GCT-->ACT). International journal of hematology 16 8011986
2019 A Comparative Analysis of p63 Expression in Giant Cell Tumour (GCT), Central Giant Cell Granuloma (CGCG) and Peripheral Giant Cell Granuloma (PGCG). Head and neck pathology 15 31873936
2014 A preliminary Quality Control (QC) for next generation sequencing (NGS) library evaluation turns out to be a very useful tool for a rapid detection of BRCA1/2 deleterious mutations. Clinica chimica acta; international journal of clinical chemistry 15 25007954
1996 Substrate and inhibitor specificity of glutamine cyclotransferase (QC). Biological chemistry Hoppe-Seyler 15 8839986
2022 Preimplantation genetic testing for human blastocysts with potential parental contamination using a quantitative parental contamination test (qPCT): an evidence-based study. Reproductive biomedicine online 14 36257886
2021 QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis. International journal of oncology 14 34036385
2016 TaSYP71, a Qc-SNARE, Contributes to Wheat Resistance against Puccinia striiformis f. sp. tritici. Frontiers in plant science 14 27148348
2016 Validation of a ligand-binding assay for active protein drug quantification following the 'free analyte QC concept'. Bioanalysis 14 27807984
2007 The association of common polymorphisms in the QPCT gene with bone mineral density in the Chinese population. Journal of human genetics 14 17687619
2006 MICA A8: a new allele within MHC class I chain-related A transmembrane region with eight GCT repeats. Human immunology 14 17174750
2002 HLA Class I typing of volunteers for a bone marrow registry: QC analysis by DNA-based methodology identifies serological typing discrepancies in the assignment of HLA-A and B antigens. Tissue antigens 14 12074711
1997 Effectiveness of automated cervical cytology rescreening using the AutoPap 300 QC System. Diagnostic cytopathology 14 9181316
2020 Carnitine, apelin and resveratrol regulate mitochondrial quality control (QC) related proteins and ameliorate acute kidney injury: role of hydrogen peroxide. Archives of physiology and biochemistry 13 32538173
2011 Management of low-stage nonseminomatous germ cell tumors of testis: SIU/ICUD Consensus Meeting on Germ Cell Tumors (GCT), Shanghai 2009. Urology 13 21986224
2002 Comparison and verification of quantitative competitive reverse transcription polymerase chain reaction (QC-RT-PCR) and real time RT-PCR for avian leukosis virus subgroup J. Journal of virological methods 13 11879687
1992 Phase II study of iproplatin (CHIP) in patients with cisplatin-refractory germ cell tumors; the need for alternative strategies in the investigation of new agents in GCT. Investigational new drugs 13 1336770
1988 Purification of GCT cell-derived human colony-stimulating factors. Experimental hematology 13 2448161
2024 Native characterization and QC profiling of human amniotic mesenchymal stromal cell vesicular fractions for secretome-based therapy. Talanta 12 38761653
2019 The GFF3toolkit: QC and Merge Pipeline for Genome Annotation. Methods in molecular biology (Clifton, N.J.) 12 30414112
2016 Winner of the Young Investigator Award of the Society for Biomaterials (USA) for 2016, 10th World Biomaterials Congress, May 17-22, 2016, Montreal QC, Canada: Aligned microribbon-like hydrogels for guiding three-dimensional smooth muscle tissue regeneration. Journal of biomedical materials research. Part A 12 26799256
2012 Investigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation. PloS one 12 23071632
2003 Polymorphism in the transmembrane region of the major histocompatibility complex class I chain-related gene A: association of five GCT repetitions with Graves' disease in children. Thyroid : official journal of the American Thyroid Association 12 14588097
2023 Clinical significance and diagnostic value of QPCT, SCEL and TNFRSF12A in papillary thyroid cancer. Pathology, research and practice 11 37060824
2023 Multi-Attribute Method (MAM) Analytical Workflow for Biotherapeutic Protein Characterization from Process Development to QC. Current protocols 11 37929772
2019 Emergency Etoposide-Cisplatin (Em-EP) for patients with germ cell tumours (GCT) and trophoblastic neoplasia (TN). BMC cancer 11 31382912
2018 PaSD-qc: quality control for single cell whole-genome sequencing data using power spectral density estimation. Nucleic acids research 11 29186545
2016 NGS-QC Generator: A Quality Control System for ChIP-Seq and Related Deep Sequencing-Generated Datasets. Methods in molecular biology (Clifton, N.J.) 11 27008019
2016 Integrated spatial health assessment of yellow perch (Perca flavescens) populations from the St. Lawrence River (QC, Canada), part B: cellular and transcriptomic effects. Environmental science and pollution research international 11 27272701
2012 Probing secondary glutaminyl cyclase (QC) inhibitor interactions applying an in silico-modeling/site-directed mutagenesis approach: implications for drug development. Chemical biology & drug design 11 22967026
2010 Development of a quantitative competitive reverse transcription polymerase chain reaction (QC-RT-PCR) for detection and quantitation of Chikungunya virus. Molecular biotechnology 11 20054667
2010 Multicentric GCT of tarsal bones in an immature skeleton: a case report with review of literature. The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons 11 20554225
2002 Detection of biogenic CO production above vascular cell cultures using a near-room-temperature QC-DFB laser. Applied physics. B, Lasers and optics 11 11911164
2023 Apicidin confers promising therapeutic effect on acute myeloid leukemia cells via increasing QPCT expression. Cancer biology & therapy 10 37381175
2022 Advancing clinical and translational research in germ cell tumours (GCT): recommendations from the Malignant Germ Cell International Consortium. British journal of cancer 10 36229581
2015 Relapse and outcome patterns of patients with central nervous system mixed malignant germ cell tumors treated without irradiation: Findings from the third international central nervous system (CNS) germ cell tumor (GCT) study. Pediatric blood & cancer 10 26054044
2013 Transarterial embolization (TAE) of sacral giant cell Tumor (GCT) using spherical parmanent embolic material superabsorbant polymer microsphere (SAP-MS). SpringerPlus 9 24353982
2005 Gemcitabine plus cisplatine and paclitaxel (GCP) in second-line treatment of germ cell tumors (GCT): a phase II study. Neoplasma 9 15875087
2015 QC of sampling processes- a first overview: from field to test portion. Journal of AOAC International 8 25807044
2015 Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct. Molecules and cells 8 26447138
2002 LPS-induced cytokine production in the monocytic cell line THP-1 determined by multiple quantitative competitive PCR (QC-PCR). Scandinavian journal of clinical and laboratory investigation 8 12469895
1983 GCT-conditioned medium: an unsuitable stimulus for monitoring granulocyte--macrophage colony-forming cells in cryopreserved bone marrow. Cryobiology 8 6831907
2018 Proxl (Protein Cross-Linking Database): A Public Server, QC Tools, and Other Major Updates. Journal of proteome research 7 30525651
2005 Detection of DNA of W. bancrofti in blood samples by QC-PCR-ELISA-based. Journal of the Egyptian Society of Parasitology 7 16333903
2001 A new flow cytometric method for simultaneous measurement of residual platelets and RBCs in plasma: validation and application for QC. Transfusion 7 11161251
2022 Evaluation of the Perioperative and Postoperative Course of Surgery for Pineal Germinoma in the SIOP CNS GCT 96 Trial. Cancers 6 35884617
2018 Creation, characterization, and assignment of opsonic values for a new pneumococcal OPA calibration serum panel (Ewha QC sera panel A) for 13 serotypes. Medicine 6 29703046
2016 The mesencephalic GCt-ICo complex and tonic immobility in pigeons (Columba livia): a c-Fos study. Brain structure & function 6 27447458
2014 GCT: What happened after 10 years of curettage and cement? Retrospective study of 46 cases. Acta ortopedica brasileira 6 25538476
2012 Primary ovarian teratoma and GCT with intra-abdominal metastasis in a dog. Journal of the American Animal Hospital Association 6 23033467
1997 AutoPap 300 QC system scoring of cervical smears without "epithelial cell abnormalities". Acta cytologica 6 9022725
1982 Secretion of plasminogen activator by the human macrophage-like cell line, GCT: separation from colony-stimulating and erythropoiesis-enhancing activities. British journal of haematology 6 6814476

Missed literature

Know a paper Affinage missed for QPCT? Flag it for the maintainers and the community.

No submissions yet.