Affinage

PSRC1

Proline/serine-rich coiled-coil protein 1 · UniProt Q6PGN9

Length
363 aa
Mass
38.8 kDa
Annotated
2026-06-10
35 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PSRC1/DDA3 is a microtubule-associated protein that governs spindle microtubule dynamics during mitosis by acting as a recruitment platform for microtubule depolymerases (PMID:18411309). It binds microtubules directly through its C-terminal domain, which both associates with the mitotic spindle and confers intrinsic microtubule-polymerizing and -bundling activity, whereas the N-terminal domain is dispensable for MT binding but required for proper spindle targeting (PMID:19738423, PMID:21473853). Through this scaffold, PSRC1 recruits the depolymerase Kif2a to the spindle and spindle poles in a microtubule-dependent manner, and its loss produces unaligned chromosomes, reduced inter-kinetochore tension, slowed anaphase chromosome movement, and stabilized spindle microtubules, phenocopying Kif2a depletion (PMID:18411309). PSRC1 coordinates a network of spindle and kinetochore factors: it tracks growing MT plus-ends via an SxIP-motif interaction with EB1 (and binds EB3) to stabilize plus-ends at the cortex and drive directional cell migration (PMID:17310996, PMID:23652583), engages the depolymerase MCAK and localizes to kinetochores (PMID:21426902), and links spindle dynamics to kinetochore composition by recruiting Ska1, which in turn targets Kif2a to MT minus-ends (PMID:26797278). This activity is tightly controlled by mitotic phosphorylation — Cdk1 and Aurora A phosphorylate PSRC1 to suppress its MT-polymerizing/bundling activities, Ser225 phosphorylation is required for its mitotic function (PMID:20117088, PMID:21473853) — and by ubiquitin-mediated degradation through the ASB7 (Cullin5–SOCS box) and c-Cbl E3 ligases, with microtubules protecting PSRC1 from ASB7-driven turnover (PMID:27697924, PMID:31722512). Antagonistic partners Mdp3 (MAP7D3) and ANKRD53 oppose PSRC1-dependent Kif2a recruitment and spindle MT polymerization, fine-tuning the balance (PMID:27284004, PMID:26820536). Beyond mitosis, PSRC1 bundles and stabilizes microtubules to restrain neurite/axon outgrowth and is downregulated during neuronal differentiation (PMID:22467851), and it is required for normal spindle assembly and chromosome segregation in oocyte meiosis (PMID:40810374). PSRC1 is embedded in p53 signaling as a direct transcriptional target — induced by p53/p73 in mouse but repressed by p53 in human cells — and modulates p53 output by inhibiting ASPP2-stimulated BAX activation and by promoting β-catenin–dependent transactivation of cyclin D1 (PMID:12082536, PMID:17310996, PMID:18291097, PMID:18793611). Independently, PSRC1 promotes macrophage cholesterol efflux and reverse cholesterol transport and suppresses atherosclerosis, acting through β-catenin/PPARγ/LXRα and ERα-dependent control of hepatic FMO3 and the gut-microbiota–TMAO axis (PMID:29378206, PMID:35690006, PMID:35613310).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 1999 Medium

    Established PSRC1/DDA3 as a p53-responsive gene, framing its initial biological context within tumor-suppressor signaling and growth control.

    Evidence Differential mRNA display with actinomycin D/cycloheximide and colony-formation assay in H1299 cells

    PMID:10618717

    Open questions at the time
    • Did not identify the gene product's molecular function
    • Mechanism of growth suppression undefined
  2. 2002 High

    Defined DDA3 as a direct transcriptional target of both p53 and p73 via a mapped response element, establishing the transcriptional wiring upstream of the protein.

    Evidence Luciferase reporter, EMSA, and p53-knockout MEFs in mouse

    PMID:12082536

    Open questions at the time
    • Species-specific direction of regulation not yet recognized
    • No link to protein function
  3. 2007 High

    Identified DDA3 as a microtubule-associated protein binding EB3 and APC2, and tied it to β-catenin signaling, revealing its cytoskeletal and oncogenic activities.

    Evidence Yeast two-hybrid, GST pull-down, co-IP, in vitro MT binding, reporter assays, siRNA

    PMID:17310996

    Open questions at the time
    • Mitotic role not yet established
    • Mechanism linking MT binding to β-catenin output unclear
  4. 2008 High

    Resolved that human DDA3 is repressed (not induced) by p53, exposing a species divergence in transcriptional control.

    Evidence ChIP, luciferase reporter, Western blot, RT-PCR in DNA-damaged human cells

    PMID:18291097

    Open questions at the time
    • Functional consequence of repression for the protein's mitotic role not addressed
  5. 2008 High

    Defined DDA3's core mitotic mechanism — recruiting the depolymerase Kif2a to the spindle to control MT dynamics and chromosome segregation.

    Evidence Mass spectrometry co-purification, siRNA, live imaging, FRAP, Kif2a-knockdown phenocopy

    PMID:18411309

    Open questions at the time
    • How DDA3 itself is targeted to poles not fully resolved
    • Regulation of recruitment timing unknown
  6. 2008 Medium

    Connected DDA3's MT function back to p53 signaling by showing it inhibits ASPP2-stimulated p53-mediated BAX transactivation.

    Evidence Yeast two-hybrid, GST pull-down, colocalization, luciferase reporter

    PMID:18793611

    Open questions at the time
    • Single-lab interaction without reciprocal in vivo validation
    • Physiological relevance to apoptosis untested
  7. 2009 Medium

    Dissected the domain architecture, assigning MT binding/spindle association to the C-terminus and a regulatory/targeting role to the N-terminus.

    Evidence In vitro MT-binding, dominant-negative overexpression, immunofluorescence, live imaging

    PMID:19738423

    Open questions at the time
    • No high-resolution structure of MT-binding region
    • Single lab
  8. 2010 Medium

    Identified Ser225 mitotic phosphorylation as functionally required, introducing phospho-regulation as a control layer on DDA3's mitotic activity.

    Evidence MS phosphosite mapping, phospho-mimic/non-phosphorylatable mutants, siRNA rescue

    PMID:20117088

    Open questions at the time
    • Responsible kinase not identified here
    • Single lab
  9. 2011 High

    Mapped a multi-site phosphocode and assigned Cdk1 and Aurora A as negative regulators of DDA3's intrinsic MT-polymerizing/bundling activities.

    Evidence MS phosphosite mapping, in vitro kinase and MT polymerization/bundling assays, phospho-mimic mutants

    PMID:21473853

    Open questions at the time
    • In vivo confirmation of site-specific kinase action limited
    • Plk1 role negative but its function on DDA3 unclear
  10. 2011 Medium

    Extended DDA3's interactome to MCAK and kinetochores, linking it to CENP-E clearance from unaligned chromosomes.

    Evidence Co-IP, immunofluorescence, siRNA depletion

    PMID:21426902

    Open questions at the time
    • Co-IP without reciprocal validation
    • Direct MCAK binding region not mapped
  11. 2012 High

    Established a non-mitotic role: DDA3 bundles/stabilizes microtubules to suppress neurite and axon outgrowth, with downregulation enabling differentiation.

    Evidence Gain/loss-of-function in PC12, N2a, hippocampal neurons; in vitro MT assays; Western blot

    PMID:22467851

    Open questions at the time
    • Upstream signals controlling DDA3 in neurons unknown
    • Relation to phospho-regulation untested in neurons
  12. 2013 High

    Defined the SxIP-motif EB1 interaction that loads DDA3 onto growing MT plus-ends, linking plus-end tracking to cortical MT stabilization and directional migration.

    Evidence Interaction mapping, TIRF and time-lapse imaging, siRNA, EGF stimulation

    PMID:23652583

    Open questions at the time
    • Role of EB1 acetylation in vivo not fully resolved
    • Integration with mitotic functions unclear
  13. 2016 High

    Identified two E3 ligases (ASB7, c-Cbl) and MT-protective stabilization controlling DDA3 abundance, establishing degradation as a key regulator of Kif2a recruitment and spindle integrity.

    Evidence Ubiquitination assays, co-IP, siRNA, epistasis rescue, immunofluorescence

    PMID:27697924 PMID:31722512

    Open questions at the time
    • c-Cbl E3 activity on DDA3 inferred rather than directly assayed
    • Cell-cycle timing of degradation not fully resolved
  14. 2016 Medium

    Revealed antagonistic regulators (Mdp3/MAP7D3, ANKRD53) and the Ska1 link, building a balanced network that tunes DDA3-dependent Kif2a recruitment and minus-end dynamics.

    Evidence Co-IP, MS/proteomics, siRNA epistasis, immunofluorescence, live imaging, rescue

    PMID:26797278 PMID:26820536 PMID:27284004

    Open questions at the time
    • Direct binding interfaces not mapped for all partners
    • Single-lab co-IP for several interactions
  15. 2018 Medium

    Opened a metabolic axis: PSRC1 promotes macrophage cholesterol efflux and suppresses atherosclerosis via β-catenin/PPARγ/LXRα activation.

    Evidence Adenoviral overexpression in RAW264.7 and apoE−/− mice, cholesterol efflux assay, Western blot, ELISA, histology

    PMID:29378206

    Open questions at the time
    • Mechanistic link between MT function and lipid metabolism unestablished
    • Overexpression-based, single lab
  16. 2022 Medium

    Established loss-of-function PSRC1 phenotypes in cholesterol homeostasis, implicating ERα-dependent FMO3 regulation and the gut-microbiota–TMAO axis in its anti-atherosclerotic role.

    Evidence PSRC1-KO/OE macrophages and mice, reverse cholesterol transport, multi-omics, FMT, ERα inhibitor rescue

    PMID:35613310 PMID:35690006

    Open questions at the time
    • Direct molecular target of PSRC1 in this pathway unknown
    • Connection to the cytoskeletal function unresolved
  17. 2025 Medium

    Extended the spindle function to meiosis, showing PSRC1 is required for normal oocyte spindle assembly, kinetochore–MT attachment, and euploidy.

    Evidence siRNA knockdown, mRNA overexpression, immunofluorescence, Taxol/nocodazole, Western blot in mouse oocytes

    PMID:40810374

    Open questions at the time
    • Whether meiotic role uses the same Kif2a/EB1 machinery not tested
    • Single study

Open questions

Synthesis pass · forward-looking unresolved questions
  • How PSRC1's microtubule-scaffolding function mechanistically connects to its metabolic and transcriptional roles, and whether a structural basis exists for its MT and partner binding, remains unresolved.
  • No structural model of PSRC1 or its MT/EB1/Kif2a interfaces
  • No unified mechanism linking spindle and cholesterol functions
  • Human disease causation not directly demonstrated in the corpus

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 6 GO:0098772 molecular function regulator activity 4 GO:0060090 molecular adaptor activity 3 GO:0005198 structural molecule activity 2
Localization
GO:0005856 cytoskeleton 5 GO:0005815 microtubule organizing center 3 GO:0005634 nucleus 2
Pathway
R-HSA-1640170 Cell Cycle 7 R-HSA-1430728 Metabolism 3 R-HSA-162582 Signal Transduction 2 R-HSA-74160 Gene expression (Transcription) 2
Partners
ANKRD53ASPP2 (TP53BP2)EB1 (MAPRE1)EB3 (MAPRE3)KIF2AMAP7D3MCAK (KIF2C)SKA1

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 DDA3 (PSRC1) was identified as a p53-regulated gene: DDA3 mRNA is transcriptionally induced by p53 in a cycloheximide-insensitive, actinomycin D-sensitive manner, indicating direct transcriptional activation without requiring de novo protein synthesis. Overexpression of DDA3 suppressed colony formation in H1299 lung carcinoma cells. Differential mRNA display, actinomycin D/cycloheximide treatment, colony formation assay Oncogene Medium 10618717
2002 Mouse DDA3 is a direct transcriptional target of both p53 and p73: a p53 response element (RE2) in the DDA3 gene was shown by luciferase reporter assay and gel mobility shift analysis to bind wild-type p53 and confer transactivation. DDA3 induction by DNA damage was absent in p53-knockout MEFs. p73 family members also transactivated DDA3 via RE2. Luciferase reporter assay, gel mobility shift assay, p53-knockout MEFs, overexpression Oncogene High 12082536
2007 DDA3 is a microtubule-associated protein that interacts with plus-end binding protein EB3. Interaction was confirmed by GST pull-down and co-immunoprecipitation (requiring intact microtubules). Interaction domains were mapped to DDA3 aa 118–241 and 242–329 (EB3 binding and MT-bundling) and EB3 N- and C-termini. DDA3 directly binds microtubules in vitro and cooperates with EB3 for MT binding. DDA3 also interacts with APC2. Ectopic expression of DDA3 and EB3 enhanced beta-catenin-dependent transactivation and cyclin D1; knockdown inhibited beta-catenin signaling and colony formation. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, in vitro microtubule-binding assay, immunofluorescence, reporter assay, siRNA knockdown Oncogene High 17310996
2008 Human DDA3 is transcriptionally repressed by p53 (opposite to mouse DDA3): p53 binds three consensus El-Deiry decamers at −1478/−1403 of the hDDA3 promoter as shown by chromatin immunoprecipitation, and luciferase analysis showed this region mediates p53-dependent repression. hDDA3 mRNA and protein are suppressed in DNA-damaged cells in a wild-type p53-dependent manner. Chromatin immunoprecipitation (ChIP), luciferase reporter assay, Western blot, real-time PCR Biochemical and biophysical research communications High 18291097
2008 DDA3 recruits microtubule depolymerase Kif2a to the mitotic spindle and spindle poles in a microtubule-dependent manner. DDA3 depletion causes unaligned chromosomes, reduced inter-kinetochore tension, decreased anaphase chromosome velocity, increased spindle MT steady-state levels, reduced MT turnover, and increased MT polymerization rate — phenocopying partial Kif2a knockdown. siRNA depletion, mass spectrometry (co-purification), immunofluorescence, live imaging, fluorescence recovery after photobleaching (FRAP) The Journal of cell biology High 18411309
2008 DDA3 interacts with ASPP2 (a p53-binding protein). The interaction domain on DDA3 maps to aa 118–241; both N- and C-terminal regions of ASPP2 bind DDA3. DDA3 dose-dependently inhibits ASPP2-stimulated p53-mediated BAX promoter activation without interfering with ASPP2–p53 binding. Yeast two-hybrid screening, GST pull-down, immunofluorescence colocalization, luciferase reporter assay Biochemical and biophysical research communications Medium 18793611
2009 Domain analysis of DDA3: the C-terminal domain directly binds microtubules in vitro and associates with the mitotic spindle in vivo; the N-terminal domain does not bind MTs but acts dominant-negatively, preventing endogenous DDA3 spindle association and reducing spindle-associated Kif2a while increasing spindle MT density. In vitro microtubule-binding assay, dominant-negative overexpression, immunofluorescence, live imaging Cell cycle Medium 19738423
2010 DDA3 is phosphorylated on Ser225 during mitosis. The phospho-mimicking S225D variant rescues DDA3-knockdown mitotic defects (unaligned chromosomes), whereas the non-phosphorylatable S225A mutant does not, demonstrating that Ser225 phosphorylation is required for DDA3's mitotic function. Mass spectrometry (phosphosite identification), phospho-mimicking and non-phosphorylatable mutants, siRNA rescue assay, immunofluorescence Biochemical and biophysical research communications Medium 20117088
2011 DDA3 interacts with MCAK (a plus-end MT depolymerase) and localizes to kinetochores. DDA3 depletion causes CENP-E accumulation at kinetochores of unaligned chromosomes; Aurora B kinase activity and chromosomal passenger complex localization are unaffected by DDA3 depletion. Co-immunoprecipitation, immunofluorescence, siRNA depletion Biochemical and biophysical research communications Medium 21426902
2011 Mitotic kinases phosphorylate DDA3 at Ser22, Ser65, Ser70, and Ser223 (identified by mass spectrometry). Unphosphorylated DDA3 has both MT-polymerizing and MT-bundling activities; phospho-mimetic mutants at these sites lose both activities while retaining MT-binding. Cdk1 and Aurora A phosphorylation negatively regulate MT-polymerizing/bundling activities in vitro; Plk1 does not. Sequential phosphorylation by Aurora A and Plk1 inhibits phosphorylation by other kinases. Mass spectrometry (phosphosite identification), in vitro kinase assay, phospho-mimicking mutants, in vitro MT polymerization and bundling assays Biochemical and biophysical research communications High 21473853
2012 DDA3 bundles and stabilizes microtubules in vivo and in vitro; overexpression increases acetylated and tyrosinated microtubule abundance. DDA3 overexpression suppresses neurite/axon outgrowth in PC12, N2a, and hippocampal neurons, while its depletion accelerates neurite/axon formation. DDA3 knockdown reduces β3-tubulin levels contributing to spontaneous neuritogenesis. DDA3 is downregulated during neuronal differentiation. Overexpression, siRNA knockdown, in vitro MT bundling/stabilization assays, immunofluorescence, PC12/N2a/hippocampal neuron cell culture, Western blot Journal of cell science High 22467851
2013 DDA3 interacts with EB1 via an SxIP motif in its C-terminal Pro/Ser-rich region, enabling MT plus-end loading and tracking in an EB1-dependent manner (shown by TIRF microscopy and time-lapse imaging). EB1-dependent loading of DDA3 stabilizes MT plus-ends at the cell cortex and facilitates directional cell migration. EB1 acetylation potentially regulates the DDA3–EB1 interaction and EGF-elicited cell migration. Biochemical interaction mapping, TIRF microscopy, time-lapse imaging, siRNA knockdown, EGF stimulation Scientific reports High 23652583
2016 ASB7 (a Cullin 5–SOCS box E3 ligase) ubiquitinates DDA3 and targets it for proteasomal degradation. Microtubule presence prevents the ASB7–DDA3 interaction, stabilizing DDA3. ASB7 knockdown increases DDA3 levels, increases Kif2a recruitment to the spindle, reduces MT polymerization, and causes unaligned chromosomes — a phenotype rescued by DDA3 deletion. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, genetic epistasis (double knockdown rescue), immunofluorescence The Journal of cell biology High 27697924
2016 Mdp3 (MAP7D3) forms a complex with DDA3 and inhibits DDA3-mediated Kif2a recruitment to the mitotic spindle. Mdp3 depletion leads to aberrant Kif2a activity at the MT minus end, decreased spindle stability, unaligned chromosomes, lagging chromosomes, and chromosome bridges. DDA3 and Mdp3 act oppositely on minus-end MT dynamics but do not affect each other's localization. Co-immunoprecipitation, siRNA knockdown, immunofluorescence, live imaging Journal of cell science High 27284004
2016 ANKRD53 interacts with DDA3 (identified by proteomic analysis) and is recruited to the mitotic spindle by DDA3. ANKRD53 counteracts DDA3 activity for spindle MT polymerization. ANKRD53 depletion delays mitosis, increases unaligned chromosomes, decreases spindle MT polymerization, activates the spindle assembly checkpoint, and causes bi-nuclei and polylobed nuclei. Proteomic/MS analysis, co-immunoprecipitation, siRNA knockdown, immunofluorescence Biochemical and biophysical research communications Medium 26820536
2016 Ska1 is recruited to kinetochores by DDA3 to stabilize end-on kinetochore–MT attachment. After Kif2a is recruited to the spindle by DDA3, Ska1 targets Kif2a to the minus-end of spindle MTs to facilitate spindle dynamics. These interactions provide a molecular link between spindle dynamics and kinetochore composition. Co-immunoprecipitation, siRNA knockdown, immunofluorescence, rescue experiments Biochemical and biophysical research communications Medium 26797278
2018 PSRC1 overexpression in macrophages reduces cellular cholesterol content, increases cholesterol efflux, and inhibits foam cell formation by upregulating PPARγ and LXRα expression. In apoE−/− mice, adenoviral PSRC1 overexpression inhibits atherosclerotic lesion development, decreases plasma TC/TG/LDL-C/inflammatory cytokines, and increases HDL-C. The β-catenin pathway (upstream of PPARγ and LXRα) is elevated in PSRC1-overexpressing liver and macrophages; NF-κB activity is decreased. Adenoviral overexpression in RAW264.7 cells and apoE−/− mice, cholesterol efflux assay, Western blot, ELISA, histology Journal of molecular and cellular cardiology Medium 29378206
2019 c-Cbl acts as an E3 ubiquitin ligase that degrades DDA3. c-Cbl depletion increases DDA3 protein levels, leading to increased Kif2a recruitment to the spindle, reduced spindle formation, chromosome alignment defects, centrosome over-duplication, and centriole amplification. siRNA knockdown, Western blot, immunofluorescence, co-immunoprecipitation (implied by E3 ligase assay) Molecules and cells Medium 31722512
2022 PSRC1 deletion in macrophages impairs reverse cholesterol transport and enhances cholesterol uptake and inflammation. PSRC1 overexpression in macrophages overexpressing PSRC1 rescues proatherogenic phenotype in TMAO-stimulated cells, partly attributed to sulfotransferase 2B1b (SULT2B1b) inhibition. PSRC1 overexpression in vitro inhibited FMO3 expression, and this effect was rescued by an ERα inhibitor, indicating ERα-mediated regulation. PSRC1 knockout/overexpression in macrophages, reverse cholesterol transport assay, hepatic RNA-seq, ERα inhibitor rescue, in vitro overexpression Journal of molecular and cellular cardiology Medium 35690006
2022 PSRC1 deletion enriches TMA-producing gut bacteria, enhances plasma TMAO and betaine production, upregulates hepatic FMO3 expression, and promotes a proinflammatory colonic phenotype. Fecal microbiota transplant from PSRC1-KO mice to apoE−/− recipients elevated TMAO, plaque lipid deposition, and macrophage accumulation. PSRC1 overexpression in vitro inhibits FMO3 via an ERα-dependent mechanism. PSRC1-KO mice, metagenomics, untargeted metabolomics, hepatic RNA-seq, fecal microbiota transplant, antibiotic treatment, in vitro overexpression with ERα inhibitor Gut microbes Medium 35613310
2025 PSRC1 is localized to spindle poles throughout all stages of mouse oocyte meiosis, co-localizing with spindle microtubules (confirmed by Taxol/nocodazole treatment). Psrc1 knockdown causes abnormal spindle morphology, sustained spindle assembly checkpoint activation, abnormal kinetochore–microtubule attachments, and increased aneuploidy. Both knockdown and overexpression of Psrc1 cause abnormal spindle assembly and increased large polar body rates. siRNA knockdown, mRNA overexpression, immunofluorescence, Taxol/nocodazole treatment, Western blot FASEB journal Medium 40810374

Source papers

Stage 0 corpus · 35 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. Journal of molecular medicine (Berlin, Germany) 76 18649068
2008 DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. The Journal of cell biology 68 18411309
2007 p53 downstream target DDA3 is a novel microtubule-associated protein that interacts with end-binding protein EB3 and activates beta-catenin pathway. Oncogene 44 17310996
2022 Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3. Gut microbes 43 35613310
1999 Identification of a novel mouse p53 target gene DDA3. Oncogene 38 10618717
2018 PSRC1 overexpression attenuates atherosclerosis progression in apoE-/- mice by modulating cholesterol transportation and inflammation. Journal of molecular and cellular cardiology 34 29378206
2008 Human DDA3 is an oncoprotein down-regulated by p53 and DNA damage. Biochemical and biophysical research communications 26 18291097
2015 Association of variants in CELSR2-PSRC1-SORT1 with risk of serum lipid traits, coronary artery disease and ischemic stroke. International journal of clinical and experimental pathology 25 26464717
2016 ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation. The Journal of cell biology 23 27697924
2013 DDA3 associates with microtubule plus ends and orchestrates microtubule dynamics and directional cell migration. Scientific reports 23 23652583
2020 Influence of PSRC1, CELSR2, and SORT1 Gene Polymorphisms on the Variability of Warfarin Dosage and Susceptibility to Cardiovascular Disease. Pharmacogenomics and personalized medicine 16 33235484
2016 DDA3 and Mdp3 modulate Kif2a recruitment onto the mitotic spindle to control minus-end spindle dynamics. Journal of cell science 16 27284004
2002 Mouse DDA3 gene is a direct transcriptional target of p53 and p73. Oncogene 16 12082536
2021 Loc680254 regulates Schwann cell proliferation through Psrc1 and Ska1 as a microRNA sponge following sciatic nerve injury. Glia 15 34115425
2012 DDA3 stabilizes microtubules and suppresses neurite formation. Journal of cell science 14 22467851
2023 Association between Genetic Variants of CELSR2-PSRC1-SORT1 and Cardiovascular Diseases: A Systematic Review and Meta-Analysis. Journal of cardiovascular development and disease 13 36975855
2016 ANKRD53 interacts with DDA3 and regulates chromosome integrity during mitosis. Biochemical and biophysical research communications 13 26820536
2011 DDA3 associates with MCAK and controls chromosome congression. Biochemical and biophysical research communications 13 21426902
2009 The N-terminal domain of DDA3 regulates the spindle-association of the microtubule depolymerase Kif2a and controls the mitotic function of DDA3. Cell cycle (Georgetown, Tex.) 13 19738423
2019 The impact of PSRC1 overexpression on gene and transcript expression profiling in the livers of ApoE-/- mice fed a high-fat diet. Molecular and cellular biochemistry 11 31838625
2008 p53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation. Biochemical and biophysical research communications 11 18793611
2022 Deficiency of proline/serine-rich coiled-coil protein 1 (PSRC1) accelerates trimethylamine N-oxide-induced atherosclerosis in ApoE-/- mice. Journal of molecular and cellular cardiology 10 35690006
2011 Mitotic kinases regulate MT-polymerizing/MT-bundling activity of DDA3. Biochemical and biophysical research communications 9 21473853
2010 Phospho-regulation of DDA3 function in mitosis. Biochemical and biophysical research communications 9 20117088
2025 (Apo)Lipoprotein Profiling with Multi-Omics Analysis Identified Medium-HDL-Targeting PSRC1 with Therapeutic Potential for Coronary Artery Disease. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 7 39985383
2016 Ska1 cooperates with DDA3 for spindle dynamics and spindle attachment to kinetochore. Biochemical and biophysical research communications 7 26797278
2002 Cloning and characterization of human and mouse DDA3 genes. Biochimica et biophysica acta 5 12427559
2023 PSRC1 Regulated by DNA Methylation Is a Novel Target for LGG Immunotherapy. Journal of molecular neuroscience : MN 4 37326762
2019 c-Cbl Acts as an E3 Ligase Against DDA3 for Spindle Dynamics and Centriole Duplication during Mitosis. Molecules and cells 3 31722512
2025 Pleiotropic Effects of an eQTL in the CELSR2/PSRC1/SORT1 Cluster That Associates With LDL-C and Resting Metabolic Rate. The Journal of clinical endocrinology and metabolism 2 39018443
2025 Psrc1 Ensures Proper Spindle Assembly and Chromosome Segregation During Mouse Oocyte Maturation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2 40810374
2004 5'-Heterogeneity of mouse Dda3 transcripts is attributed to differential initiation of transcription and alternative splicing. Archives of biochemistry and biophysics 2 15111131
2025 Phosphocreatine alleviates monocrotaline-induced liver injury dependent on PSRC1-regulated endoplasmic reticulum stress. Biochemical pharmacology 1 40194605
2026 Causal statistical association between remnant cholesterol and coronary heart disease: genetic insights into the PSRC1-CELSR2-SORT1 gene cluster. Journal of lipid research 0 42019808
2023 Polymorphism of rs599839 in the PSRC1 gene is associated with coronary artery disease in an Iranian population. Journal of cardiovascular and thoracic research 0 38028723

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