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Showing CTDSPL — PSR1 is a alias.

CTDSPL

CTD small phosphatase-like protein · UniProt O15194

Length
276 aa
Mass
31.1 kDa
Annotated
2026-06-09
53 papers in source corpus 15 papers cited in narrative 15 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CTDSPL (alias SCP3/RBSP3/HYA22) is a small C-terminal domain HAD-type phosphatase that operates in two distinct biological contexts: structural assembly of the meiotic synaptonemal complex and dephosphorylation-driven cell cycle control (PMID:9679134, PMID:15051889). In meiosis, the protein self-assembles—via its C-terminal coiled-coil and N-terminal non-helical domains—into cross-striated, intermediate filament-like fibers that constitute the molecular framework of synaptonemal complex lateral elements (PMID:9679134, PMID:24192369). Null mutation abolishes axial/lateral element and synaptonemal complex formation, prevents chromosomal synapsis, mislocalizes the recombination proteins Rad51 and RPA and the partner SCP1, and causes apoptotic arrest and sterility in males (PMID:10678170); in females it is required for chiasmata formation and chromosome segregation, with its loss producing age-dependent oocyte aneuploidy (PMID:12004129). Its removal from chromosomes during meiotic progression is driven by phosphorylation (PMID:9914155), and it co-localizes with the cohesin subunit Rad21 and accumulates at centromeres with INCENP and aurora-B, implicating it in monopolar sister-kinetochore attachment in meiosis I (PMID:14970259). In somatic and cancer contexts the same gene acts as a tumor suppressor: it directly binds RB and dephosphorylates it to enforce G1/S arrest, suppresses tumor formation in vivo, and is mutated and deleted at the 3p21.3 locus (PMID:15051889, PMID:27414789). This RB-dephosphorylating activity is suppressed by oncogenic microRNAs—miR-100, miR-181b, and miR-18a-5p target its 3′UTR to relieve RB phosphorylation and drive E2F1-dependent proliferation or, conversely, modulate cellular senescence (PMID:21643017, PMID:29382357, PMID:38460957). In immunoedited tumor cells the protein conversely promotes aggressive phenotypes by hyperactivating the cyclin D1–CDK4/6–NANOG axis and by interacting with JAB1 to activate EGF–EGFR–AKT signaling (PMID:29437706, PMID:34445562). Its catalytic HAD phosphatase function is evolutionarily conserved, as human CTDSPL complements yeast Psr1/Psr2 to restore TORC1 inhibition and autophagy (PMID:40103213).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1998 High

    Established the structural basis of the protein's meiotic role by showing it intrinsically self-assembles into the fiber framework of synaptonemal complex lateral elements.

    Evidence Expression in cultured somatic cells with TEM/immuno-EM and domain-deletion mutagenesis

    PMID:9679134

    Open questions at the time
    • Atomic-resolution assembly mechanism not resolved
    • Did not test in vivo requirement of each domain during meiosis
  2. 1998 Medium

    Addressed how the protein is cleared from chromosomes, showing phosphorylation accompanies its meiotic displacement.

    Evidence In vitro kinase assays using pachytene vs metaphase I spermatocyte extracts

    PMID:9914155

    Open questions at the time
    • Responsible kinase not identified
    • Phosphosites not mapped
    • Causality of phosphorylation in removal not directly demonstrated in vivo
  3. 2000 High

    Demonstrated the protein is genetically essential for synaptonemal complex assembly and male meiotic progression.

    Evidence Null knockout in male mice with immunofluorescence and histology

    PMID:10678170

    Open questions at the time
    • Mechanism linking SC loss to apoptotic checkpoint not defined
    • Did not address female meiosis
  4. 2002 High

    Extended the meiotic role to females, establishing requirement for chiasmata and segregation fidelity and linking loss to maternal-age aneuploidy.

    Evidence Knockout female mice with oocyte/embryo karyotyping and immunofluorescence

    PMID:12004129

    Open questions at the time
    • Molecular basis of age-dependent aneuploidy increase unresolved
  5. 2004 Medium

    Positioned the protein relative to cohesin and passenger proteins, implicating it in monopolar kinetochore attachment in meiosis I.

    Evidence Immunofluorescence co-localization (Rad21, INCENP, aurora-B) in mouse spermatocytes

    PMID:14970259

    Open questions at the time
    • No direct functional disruption to test causal role in monopolar attachment
    • Co-localization does not establish physical complex
  6. 2004 High

    Defined a distinct somatic function—an RB-dephosphorylating phosphatase that enforces G1/S arrest and suppresses tumors at the 3p21.3 locus.

    Evidence Sequence analysis, regulated transgene growth suppression, SCID mouse tumor assay, pRB dephosphorylation assay

    PMID:15051889

    Open questions at the time
    • Direct enzyme-substrate kinetics on RB not characterized here
    • RB phosphosite specificity undefined
  7. 2011 Medium

    Placed the gene downstream of an oncomiR, showing miR-100 suppression of the gene relieves the pRB/E2F1 brake on proliferation and differentiation.

    Evidence miRNA target validation, siRNA phenocopy, flow cytometry, western blot in AML cells

    PMID:21643017

    Open questions at the time
    • Direct 3′UTR binding site not mapped in this study
    • Single lineage context
  8. 2016 Medium

    Confirmed the RB interaction is direct and physical, supporting the dephosphorylation mechanism.

    Evidence GST pull-down and surface plasmon resonance with MCF-7 extracts

    PMID:27414789

    Open questions at the time
    • Interaction interface not mapped
    • Single lab; no cellular reciprocal validation
  9. 2017 Medium

    Revealed context-dependent oncogenic potential, where truncated/dysregulated forms promote migration and immortalization.

    Evidence Viral integration site sequencing in chicken B-cell lymphomas plus overexpression, migration, and immortalization assays

    PMID:28915671

    Open questions at the time
    • Mechanism of truncated-transcript oncogenicity unresolved
    • Avian system; relevance to human tumors not tested
  10. 2018 Medium

    Identified pro-tumorigenic signaling outputs, placing the protein upstream of cyclin D1–CDK4/6–NANOG and of a JAB1-driven EGF–EGFR–AKT axis.

    Evidence Overexpression with palbociclib epistasis (NANOG axis) and yeast two-hybrid plus EGF neutralization (JAB1/EGF axis), Western blot

    PMID:29437706 PMID:34445562

    Open questions at the time
    • Reciprocal Co-IP for JAB1 interaction not shown
    • Reconciliation of tumor-suppressor vs aggressive phenotypes left unresolved
    • Phosphatase-dependence of these outputs untested
  11. 2018 Medium

    Broadened the oncomiR regulatory network, showing miR-181b directly targets the 3′UTR to drive RB phosphorylation and E2F1-dependent cell cycle progression.

    Evidence Dual-luciferase reporter, microarray, siRNA phenocopy, flow cytometry in uveal melanoma

    PMID:29382357

    Open questions at the time
    • Single tumor type
    • In vivo relevance not established
  12. 2024 Medium

    Linked the gene's RB-arrest activity to cellular senescence, showing overexpression drives premature MSC senescence under miR-18a-5p control.

    Evidence Overexpression, luciferase reporter, SA-β-gal, Western blot (p16, pRB), flow cytometry

    PMID:38460957

    Open questions at the time
    • Catalytic requirement for senescence not tested
    • p16 induction mechanism unclear
  13. 2025 Medium

    Established that the catalytic HAD phosphatase activity is conserved and functionally relevant to TORC1/autophagy control.

    Evidence Yeast complementation by human CTDSPL with active-site mutagenesis, TORC1 activity and autophagy readouts

    PMID:40103213

    Open questions at the time
    • Direct TORC1-pathway substrate of human CTDSPL not identified
    • Tested only in heterologous yeast system

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single gene reconciles its meiotic structural fiber role, its tumor-suppressive RB phosphatase activity, and its pro-tumorigenic JAB1/EGF and CDK4/6–NANOG outputs in a unified mechanistic framework remains unresolved.
  • No refined high-resolution structure of full-length protein or fiber
  • Human RB phosphosites and TORC1-relevant substrates unmapped
  • Determinants switching tumor-suppressor vs oncogenic behavior unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 2 GO:0016787 hydrolase activity 2 GO:0140096 catalytic activity, acting on a protein 2
Localization
GO:0005634 nucleus 2 GO:0005694 chromosome 2
Pathway
R-HSA-1640170 Cell Cycle 3 R-HSA-1474165 Reproduction 2 R-HSA-162582 Signal Transduction 2
Partners
JAB1RAD21RB1SCP1
Complex memberships
synaptonemal complex lateral element

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 SCP3 self-assembles into thick, cross-striated fibers when synthesized in cultured somatic cells; this process requires both the C-terminal coiled-coil domain and the N-terminal non-helical domain. The fibers display ~20 nm transversal striation and consist of closely associated 5–10 nm thin fibers resembling intermediate filaments, consistent with SCP3 forming the molecular framework of synaptonemal complex lateral elements. Expression in cultured somatic cells, transmission electron microscopy, immunoelectron microscopy, domain-deletion mutagenesis The Journal of cell biology High 9679134
1998 SCP3 (COR1) and SCP1 (SYN1) are efficiently phosphorylated in vitro by extracts from isolated pachytene spermatocytes; extracts from metaphase I cells (in which SCP3 has been displaced from chromosomes) lack this kinase activity. This supports a model in which phosphorylation of SCP3 drives its removal from chromosomes during meiotic progression. In vitro kinase assay using pachytene and metaphase I cell extracts; okadaic acid-induced meiotic progression model Journal of cell science Medium 9914155
2000 SCP3 null mutation in male mice abolishes axial/lateral element and synaptonemal complex formation, prevents chromosomal synapsis, and causes massive apoptotic cell death during meiotic prophase with sterility. Loss of SCP3 also disrupts nuclear distribution of DNA repair/recombination proteins Rad51 and RPA, and prevents SCP1 localization, establishing SCP3 as essential for the structural assembly of the synaptonemal complex. Gene knockout (null mutation), immunofluorescence, histology Molecular cell High 10678170
2002 SCP3-deficient female mice produce aneuploid oocytes due to defective meiotic chromosome segregation; SCP3 is required for chiasmata formation and structural integrity of meiotic chromosomes. Loss of SCP3 triggers nondisjunction, and the resulting aneuploidy increases with advancing maternal age. Gene knockout, karyotyping of oocytes and embryos, immunofluorescence Science (New York, N.Y.) High 12004129
2004 SCP3 colocalizes with cohesin subunit Rad21 at synaptonemal complex lateral elements, accumulates at centromeres during late prophase I together with chromosomal passenger proteins INCENP and aurora-B kinase in a 'double cornet' configuration, and both are displaced from centromeres at telophase I when sister kinetochores separate. This positional behavior implicates SCP3 in monopolar attachment of sister kinetochores during meiosis I. Immunofluorescence co-localization in mouse spermatocytes using squashing technique; antibodies against SCP3, Rad21, INCENP, aurora-B Journal of cell science Medium 14970259
2004 RBSP3/HYA22 (CTDSPL) encodes a small C-terminal domain phosphatase that dephosphorylates pRB, leading to cell cycle arrest at G1/S. Expression of RBSP3 suppresses tumor formation in SCID mice. The gene carries missense and nonsense mutations in tumors and is located in the frequently deleted 3p21.3 AP20 region. Sequence analysis, regulated transgene expression (growth suppression assay), SCID mouse tumor suppression assay, pRB dephosphorylation assay Proceedings of the National Academy of Sciences of the United States of America High 15051889
2011 RBSP3 (CTDSPL) is a direct target of miR-100 in AML cells. miR-100 suppresses RBSP3 expression, which in turn modulates pRB phosphorylation and E2F1 levels, promoting G1/S transition and blocking granulocyte/monocyte differentiation. RBSP3 knockdown by siRNA phenocopies miR-100 overexpression, confirming RBSP3 acts downstream of miR-100 to regulate the pRB/E2F1 axis. miRNA target validation, siRNA knockdown, cell cycle analysis (flow cytometry), western blot for pRB/E2F1 Oncogene Medium 21643017
2016 CTDSPL directly binds RB protein: GST pull-down assay showed CTDSPL precipitates RB from MCF-7 cell extracts, and surface plasmon resonance confirmed the interaction is direct and physical, supporting the mechanism by which CTDSPL dephosphorylates and activates RB to arrest the cell cycle at G1/S. GST pull-down, surface plasmon resonance (SPR) Molekuliarnaia biologiia Medium 27414789
2017 ALV integration into CTDSPL in chicken B-cell lymphomas drives expression of truncated fusion transcripts. Overexpression of CTDSPL in chick embryo fibroblasts promotes cell migration. Truncated viral fusion transcripts of CTDSPL promote immortalization in primary cell culture, revealing oncogenic properties when the gene is dysregulated. Deep sequencing of viral integration sites, overexpression in chick embryo fibroblasts, cell migration assay, immortalization assay Oncotarget Medium 28915671
2018 SCP3 (CTDSPL) overexpression in immunoedited tumor cells upregulates NANOG by hyperactivating the cyclin D1–CDK4/6 axis. CDK4/6 inhibitor palbociclib reverses SCP3-mediated aggressive phenotypes including cancer stem cell properties and immune refractoriness, placing SCP3 upstream of cyclin D1–CDK4/6–NANOG in this pathway. Overexpression studies, CDK4/6 inhibitor treatment, genetic epistasis (palbociclib reversal), Western blot Cancer research Medium 29437706
2018 CTDSPL is a direct target of miR-181b in uveal melanoma cells. Dual-luciferase reporter assay confirmed miR-181b binds the CTDSPL 3′UTR. miR-181b overexpression inhibits CTDSPL, leading to RB phosphorylation and E2F1 accumulation that drives cell cycle progression. siRNA knockdown of CTDSPL phenocopies miR-181b overexpression. Dual-luciferase reporter assay, microarray, RT-PCR, siRNA knockdown, flow cytometry Journal of experimental & clinical cancer research : CR Medium 29382357
2021 SCP3 physically interacts with JAB1 (Jun activation domain-binding protein 1), identified by yeast two-hybrid assay. This SCP3–JAB1 interaction drives transcriptional activation of EGF, which activates the EGFR–AKT signaling pathway. Neutralization of secreted EGF with a monoclonal antibody reverses SCP3-mediated aggressive phenotypes and EGFR–AKT activation, placing SCP3 upstream of the EGF–EGFR–AKT axis. Yeast two-hybrid assay, EGF neutralization with monoclonal antibody, Western blot for EGFR/AKT activation International journal of molecular sciences Medium 34445562
2024 CTDSPL overexpression in mesenchymal stem cells induces premature senescence, characterized by enlarged morphology, upregulation of p16, SA-β-gal accumulation, and reduced phosphorylated RB indicating cell cycle arrest. miR-18a-5p targets the CTDSPL 3′UTR (validated by luciferase reporter assay) and its inhibition promotes CTDSPL expression and MSC senescence. Overexpression, luciferase reporter assay, SA-β-gal staining, Western blot (p16, pRB), flow cytometry Aging Medium 38460957
2025 Human CTDSPL (along with CTDSP1 and CTDSP2) can functionally replace yeast Psr1 and Psr2 HAD-type phosphatases in restoring TORC1 inhibition and autophagy activation in response to low leucine conditions, demonstrating conserved phosphatase function across species. Mutation of the active site of Psr1 abolishes its inhibitory effects on TORC1, confirming the phosphatase catalytic activity is essential. Yeast complementation assay (human CTDSPL replacing yeast Psr1/Psr2), active-site mutagenesis, TORC1 activity assay, autophagy readout Autophagy Medium 40103213
2013 Crystallization of the SCP3 C-terminal coiled-coil domain was achieved with X-ray diffraction data collected to 3.2 Å resolution (space group C2), with three molecules in the asymmetric unit, providing structural groundwork for understanding the coiled-coil domain critical for fiber self-assembly. Recombinant protein expression in E. coli, purification, X-ray crystallography Acta crystallographica. Section F, Structural biology and crystallization communications Low 24192369

Source papers

Stage 0 corpus · 53 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility. Molecular cell 583 10678170
2002 Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3. Science (New York, N.Y.) 273 12004129
1999 Psr1, a nuclear localized protein that regulates phosphorus metabolism in Chlamydomonas. Proceedings of the National Academy of Sciences of the United States of America 191 10611385
2006 Genome-based approaches to understanding phosphorus deprivation responses and PSR1 control in Chlamydomonas reinhardtii. Eukaryotic cell 132 16400166
2004 Involvement of the cohesin Rad21 and SCP3 in monopolar attachment of sister kinetochores during mouse meiosis I. Journal of cell science 126 14970259
2011 MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia. Oncogene 104 21643017
2000 The meiotic specific synaptonemal complex protein SCP3 is expressed by female and male primordial germ cells of the mouse embryo. The International journal of developmental biology 94 10794082
1998 The synaptonemal complex protein SCP3 can form multistranded, cross-striated fibers in vivo. The Journal of cell biology 89 9679134
1985 Molecular and functional organization of yeast plasmid pSR1. Journal of molecular biology 88 3889347
1998 Localization of SCP2 and SCP3 protein molecules within synaptonemal complexes of the rat. Chromosoma 84 9933407
2013 Release of arsenic from soil by a novel dissimilatory arsenate-reducing bacterium, Anaeromyxobacter sp. strain PSR-1. Applied and environmental microbiology 83 23709511
2015 PSR1 Is a Global Transcriptional Regulator of Phosphorus Deficiency Responses and Carbon Storage Metabolism in Chlamydomonas reinhardtii. Plant physiology 78 26704642
2004 RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies. Proceedings of the National Academy of Sciences of the United States of America 66 15051889
1999 Meiotic activation of rat pachytene spermatocytes with okadaic acid: the behaviour of synaptonemal complex components SYN1/SCP1 and COR1/SCP3. Journal of cell science 50 9914155
2018 The miR-181 family promotes cell cycle by targeting CTDSPL, a phosphatase-like tumor suppressor in uveal melanoma. Journal of experimental & clinical cancer research : CR 48 29382357
2010 Simultaneous down-regulation of tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer. BMC cancer 44 20193080
2015 A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Nature communications 41 25564762
1992 Site-specific recombinase, R, encoded by yeast plasmid pSR1. Journal of molecular biology 36 1583692
2022 Phytophthora effector PSR1 hijacks the host pre-mRNA splicing machinery to modulate small RNA biogenesis and plant immunity. The Plant cell 35 35699507
2019 The WY domain in the Phytophthora effector PSR1 is required for infection and RNA silencing suppression activity. The New phytologist 35 30963588
2018 Targeting Cyclin D-CDK4/6 Sensitizes Immune-Refractory Cancer by Blocking the SCP3-NANOG Axis. Cancer research 33 29437706
2007 Mammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovaries. Cell cycle (Georgetown, Tex.) 31 18256545
2009 High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer. PloS one 26 19478941
2019 Lipid remodeling regulator 1 (LRL1) is differently involved in the phosphorus-depletion response from PSR1 in Chlamydomonas reinhardtii. The Plant journal : for cell and molecular biology 25 31350858
2008 [Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer]. Molekuliarnaia biologiia 25 19140316
1993 The DNA sequence and minimal replicon of the Corynebacterium glutamicum plasmid pSR1: evidence of a common ancestry with plasmids from C. diphtheriae. Journal of general microbiology 22 8409918
1988 Gene conversion associated with site-specific recombination in yeast plasmid pSR1. Molecular and cellular biology 19 3280974
2017 Integration of ALV into CTDSPL and CTDSPL2 genes in B-cell lymphomas promotes cell immortalization, migration and survival. Oncotarget 18 28915671
1991 Mutations in a Saccharomyces cerevisiae host showing increased holding stability of the heterologous plasmid pSR1. Molecular & general genetics : MGG 18 2005867
2015 Draft Genome Sequence of Anaeromyxobacter sp. Strain PSR-1, an Arsenate-Respiring Bacterium Isolated from Arsenic-Contaminated Soil. Genome announcements 16 25977440
2020 Possible Involvement of a Tetrathionate Reductase Homolog in Dissimilatory Arsenate Reduction by Anaeromyxobacter sp. Strain PSR-1. Applied and environmental microbiology 14 32978134
2014 Responsiveness of four gender-specific genes, figla, foxl2, scp3 and sox9a to 17α-ethinylestradiol in adult rare minnow Gobiocypris rarus. General and comparative endocrinology 12 24631545
2025 GPX modulation promotes regenerative axonal fusion and functional recovery after injury through PSR-1 condensation. Nature communications 8 39870634
2007 [Tumor suppressor gene RBSP3 in cervical carcinoma: copy number and transcriptional level]. Molekuliarnaia biologiia 7 17380895
2023 Hsa-miR-503-5p regulates CTDSPL to accelerate cisplatin resistance and angiogenesis of lung adenocarcinoma cells. Chemical biology & drug design 6 37341065
2023 Overexpression of PSR1 in Chlamydomonas reinhardtii induces luxury phosphorus uptake. Frontiers in plant science 6 37575910
2014 Expression of miR-100 and RBSP3 in FTC-133 cells after exposure to 131I. Nuclear medicine communications 6 24785011
2019 Effects of body temperature on the expression and localization of meiosis-related proteins STRA8 and SCP3 in boar testes. Acta histochemica 5 31253359
2018 Differential transmission of the molecular signature of RBSP3, LIMD1 and CDC25A in basal/ parabasal versus spinous of normal epithelium during head and neck tumorigenesis: A mechanistic study. PloS one 5 29672635
2016 Scp3 expression in relation to the ovarian differentiation in the protogynous hermaphroditic ricefield eel Monopterus albus. Fish physiology and biochemistry 5 27277446
2016 [Interaction of two tumor suppressors: Phosphatase CTDSPL and Rb protein]. Molekuliarnaia biologiia 4 27414789
2016 Association of P16-RBSP3 inactivation with phosphorylated RB1 overexpression in basal-parabasal layers of normal cervix unchanged during CACX development. The Biochemical journal 4 27458253
2018 Preferential allelic deletion of RBSP3, LIMD1 and CDC25A in head and neck squamous cell carcinoma: Implication in cancer screening and early detection. Cancer biology & therapy 2 29624473
1993 A specific host factor binds at a cis-acting transcriptionally silent locus required for stability control of yeast plasmid pSR1. Molecular & general genetics : MGG 2 8479419
2025 The Whi2-Psr1-Psr2 complex selectively regulates TORC1 and autophagy under low leucine conditions but not nitrogen depletion. Autophagy 1 40103213
2025 A histone demethylase is involved in regulating the transcription factor PSR1 for carbon storage in Chlamydomonas. The Plant journal : for cell and molecular biology 1 40384610
2024 MicroRNA-18a prevents senescence of mesenchymal stem cells by targeting CTDSPL. Aging 1 38460957
2024 Psr1 phosphatase regulates pre-mRNA splicing through spliceosomal B complex factor Snu66. The FEBS journal 1 39484844
2023 Expression of scp3 and dazl reveals the meiotic characteristics of the olive flounder Paralichthys olivaceus†. Biology of reproduction 1 36308428
2015 Fission yeast Scp3 potentially maintains microtubule orientation through bundling. PloS one 1 25767875
2026 miR-100-5p Enhances Cell Cycle-Mediated Chemoresistance by Modulating the CTDSPL/pRB/E2F1 Signaling Pathway in Oxaliplatin-Resistant Colorectal Cancer Cells. Oncology research 0 41930162
2021 Interaction between SCP3 and JAB1 Confers Cancer Therapeutic Resistance and Stem-like Properties through EGF Expression. International journal of molecular sciences 0 34445562
2013 Expression, crystallization and preliminary X-ray crystallographic studies of SCP3 coiled-coil domain. Acta crystallographica. Section F, Structural biology and crystallization communications 0 24192369

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