Affinage

PRKCQ

Protein kinase C theta type · UniProt Q04759

Round 2 corrected
Length
706 aa
Mass
81.9 kDa
Annotated
2026-04-28
54 papers in source corpus 21 papers cited in narrative 20 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PRKCQ (PKCθ) is a calcium-independent, diacylglycerol-activated serine/threonine kinase of the novel PKC subfamily that functions as a central signaling node in T cell activation and metabolic regulation. Upon antigen receptor engagement and CD28 costimulation, PKCθ selectively translocates to the immunological synapse—unique among PKC isoforms—where it phosphorylates CARMA1 on linker-region serines to convert it to an active conformer that recruits the IKK signalosome, thereby serving as the essential link between TCR signaling and NF-κB activation (PMID:8985252, PMID:10746729, PMID:16356855). PKCθ cooperates with calcineurin to activate JNK and IL-2 transcription, is sequestered from the Treg immunological synapse such that its inhibition enhances regulatory T cell suppressive function, and is cleaved by caspase-3 during apoptosis to generate a pro-apoptotic kinase fragment (PMID:9606192, PMID:20339032, PMID:9252332). Outside the immune system, PKCθ phosphorylates IRS-1 at Ser1101 downstream of diacylglycerol accumulation, directly inhibiting insulin receptor signaling and constituting a key mechanism of lipid-induced skeletal muscle insulin resistance in humans (PMID:15364919, PMID:24979806).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1993 High

    Molecular cloning established PRKCQ as a novel, calcium-independent PKC isoform with predominant hematopoietic expression, positioning it as a candidate signaling kinase in T cells.

    Evidence cDNA cloning, RNase protection assay, and immunoprecipitation with isoform-specific antisera

    PMID:8444877

    Open questions at the time
    • No substrate or signaling pathway yet assigned
    • Enzymatic regulation by DAG/lipid cofactors not characterized at this stage
  2. 1997 High

    Discovery that PKCθ selectively translocates to the T cell–APC contact site, while other PKC isoforms do not, established its unique spatial role at the immunological synapse and suggested a non-redundant function in antigen recognition.

    Evidence Digital immunofluorescence microscopy of T cell–APC conjugates with isoform-specific antibodies and in vitro kinase assays

    PMID:8985252

    Open questions at the time
    • Mechanism of selective synapse recruitment unknown
    • Downstream substrates at the synapse not identified
  3. 1997 High

    Identification of caspase-3 cleavage at DEVD354 in the V3 domain revealed a mechanism by which apoptotic signaling converts PKCθ into a constitutively active pro-apoptotic fragment, linking PKCθ to programmed cell death.

    Evidence In vitro caspase-3 cleavage assay, overexpression of wild-type versus kinase-inactive truncation mutants, DNA content analysis

    PMID:9252332

    Open questions at the time
    • Physiological relevance of caspase-cleaved fragment in primary T cells not tested
    • Whether cleavage acts as positive feedback during T cell apoptosis unknown
  4. 1998 High

    Demonstration that PKCθ cooperates with calcineurin to synergistically activate JNK and IL-2 transcription, converging on or upstream of Rac, identified the first signaling pathway through which PKCθ drives T cell effector gene expression.

    Evidence Isoform-selective downregulation, cyclosporin A, dominant-negative constructs, and reporter assays in Jurkat T cells

    PMID:9606192

    Open questions at the time
    • Direct kinase substrate in the calcineurin–PKCθ–JNK axis not identified
    • In vivo relevance not addressed
  5. 2000 High

    PKCθ knockout mice demonstrated that PKCθ is essential and non-redundant for TCR-mediated NF-κB activation in mature T cells but dispensable for thymocyte development, establishing NF-κB as the critical PKCθ-dependent pathway; CD28 costimulation was shown to specifically enhance PKCθ membrane translocation and catalytic activation.

    Evidence Prkcq−/− mice with NF-κB EMSA/reporter, cytokine stimulation controls; PKC isoform overexpression and inhibitor studies in parallel

    PMID:10716728 PMID:10746729

    Open questions at the time
    • Direct phosphorylation substrate linking PKCθ to IKK not yet identified
    • Whether PKCθ acts through a scaffold protein unknown
  6. 2004 High

    Identification of IRS-1 Ser1101 as a direct PKCθ phosphorylation site that blocks insulin-stimulated tyrosine phosphorylation and Akt activation provided the first mechanistic link between PKCθ and metabolic insulin resistance, extending PKCθ function beyond immunity.

    Evidence In vitro kinase assay with S1101A mutagenesis and IRS-1/Akt phosphorylation readouts in cultured cells

    PMID:15364919

    Open questions at the time
    • In vivo relevance in muscle tissue not yet demonstrated at this point
    • Upstream DAG-PKCθ activation mechanism in metabolic context not resolved
  7. 2005 High

    The discovery that PKCθ directly phosphorylates CARMA1 on linker-region serines (S552/S564/S649/S657) to convert it to an active conformer recruiting the IKK signalosome closed the mechanistic gap between PKCθ synapse translocation and NF-κB activation.

    Evidence In vitro kinase assay, site-directed mutagenesis, reconstitution in CARMA1-deficient T cells, lipid raft fractionation; independently confirmed by two groups

    PMID:16356855 PMID:16356856

    Open questions at the time
    • Structural basis for CARMA1 conformational change upon phosphorylation unknown
    • Whether additional PKCθ substrates at the synapse contribute to NF-κB remains open
  8. 2010 High

    The finding that PKCθ is excluded from the Treg immunological synapse and that PKCθ inhibition enhances Treg suppressive function—including rescue of dysfunctional Tregs from rheumatoid arthritis patients—revealed an unexpected dichotomy in PKCθ function between effector and regulatory T cells.

    Evidence Immunofluorescence, pharmacological PKCθ inhibitor, Treg suppression assays in vitro and in a colitis model in vivo

    PMID:20339032

    Open questions at the time
    • Mechanism of PKCθ exclusion from Treg synapse not identified
    • Whether Treg-specific PKCθ inhibition is therapeutically feasible without compromising effector T cell immunity unclear
  9. 2014 High

    Human muscle biopsy studies during lipid infusion directly demonstrated temporal association between DAG accumulation, PKCθ activation, IRS-1 Ser1101 phosphorylation, and impaired insulin signaling, validating the DAG–PKCθ–IRS-1 axis as a central mechanism of lipid-induced insulin resistance in humans.

    Evidence Serial muscle biopsies during lipid infusion in lean, obese, and T2D subjects with DAG, PKCθ, and IRS-1/AKT phosphorylation measurements

    PMID:24979806

    Open questions at the time
    • Whether genetic variation at PRKCQ locus affects insulin sensitivity unknown
    • Whether PKCθ inhibition reverses established insulin resistance in humans not tested
  10. 2016 High

    Extending PKCθ biology to cancer, kinase-active PKCθ was shown to drive Erk/MAPK-dependent Rb phosphorylation, anchorage-independent survival, and xenograft tumor growth in triple-negative breast cancer, with subsequent work demonstrating kinase-dependent suppression of pro-apoptotic Bim as a chemoresistance mechanism.

    Evidence Gain/loss-of-function with kinase-active versus kinase-inactive mutants, shRNA, small-molecule inhibitors, xenograft models, Bim rescue experiments

    PMID:27663795 PMID:32600444

    Open questions at the time
    • Direct PKCθ substrate responsible for Bim suppression not identified
    • Clinical relevance of PKCθ inhibition in TNBC not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis for PKCθ's unique immunological synapse recruitment, the identity of additional synapse substrates beyond CARMA1, the precise mechanism by which PKCθ is excluded from the Treg synapse, and whether selective PKCθ inhibition can achieve therapeutic separation between Treg enhancement and effector T cell suppression.
  • No crystal structure of full-length PKCθ in a signaling complex
  • No in vivo demonstration of therapeutic PKCθ inhibitor selectivity in autoimmune disease
  • Mechanism of synapse-specific PKCθ exclusion in Tregs unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 5 GO:0016740 transferase activity 3
Localization
GO:0005886 plasma membrane 3 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 6 R-HSA-168256 Immune System 6 R-HSA-1430728 Metabolism 2 R-HSA-5357801 Programmed Cell Death 2
Partners
CARD11CASP3IRS1PDCD1PPP3CA

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1993 PKCθ (PRKCQ) was molecularly cloned and characterized as a novel serine/threonine kinase member of the PKC family, expressed predominantly in hematopoietic cells (T cells, thymocytes). It encodes an ~82 kDa protein, lacks the Ca2+-binding C2 domain (Ca2+-independent), and shows highest homology to PKCδ. cDNA cloning, PCR, RNase protection assay, immunoprecipitation with isoform-specific antiserum The Journal of biological chemistry High 8444877
1997 PKCθ selectively translocates to the T cell–APC contact site (immunological synapse) upon antigen-specific T cell activation, where its kinase activity is selectively increased; other PKC isoforms (α, βI, βII, δ, ε) do not translocate to this site. Digital immunofluorescence microscopy of T cell–APC conjugates; in vitro kinase activity assay of PKC immunoprecipitates Nature High 8985252
1997 PKCθ is cleaved by Caspase-3 in the V3 domain at DEVD354/K during apoptosis; overexpression of the cleaved kinase-active fragment (but not full-length or kinase-inactive PKCθ) induces apoptosis (sub-G1 DNA, nuclear fragmentation, lethality). In vitro Caspase-3 cleavage assay, overexpression of wild-type and mutant PKCθ constructs, DNA content analysis The Journal of biological chemistry High 9252332
1998 PKCθ (but not PKCα or PKCε) cooperates with calcineurin to synergistically activate JNK and drive c-jun and IL-2 promoter transcription in T lymphocytes; this cooperation converges on or upstream of Rac. Isoform-selective PKC downregulation, pharmacological inhibition (cyclosporin A), reporter gene assays, dominant-negative constructs in Jurkat T cells The EMBO journal High 9606192
1998 The human PRKCQ gene locus maps to chromosome 10p15, spans ~62 kb, and is composed of 15 coding exons and 14 introns; 7 of 14 intron positions are conserved with the Drosophila dPRKC gene. FISH, P1 genomic clone isolation, long-range PCR, DNA sequencing Molecular & general genetics : MGG High 9790596
2000 PKCθ is required for TCR-mediated NF-κB activation in mature T lymphocytes but is dispensable for TCR-dependent thymocyte development; TNF-α- and IL-1-induced NF-κB activation is unaffected in PKCθ-/- cells; TCR-induced JNK activation is normal in PKCθ-/- T cells. PKCθ knockout mice, T cell activation assays, NF-κB reporter/EMSA, cytokine stimulation Nature High 10746729
2000 PKCθ is uniquely capable among PKC isoforms of activating NF-κB and the CD28RE/AP-1 element in T cells; CD28 costimulation enhances PKCθ membrane translocation and catalytic activation; PKCθ-mediated NF-κB activation involves IKKβ/IκB signaling cascade. Reporter gene assays, PKC isoform overexpression, pharmacological PKCθ inhibitor, IκB degradation inhibitor (MG132), T cell transfection Proceedings of the National Academy of Sciences of the United States of America High 10716728
2004 PKCθ phosphorylates IRS-1 at Ser1101, blocking IRS-1 tyrosine phosphorylation and downstream Akt pathway activation; mutation of Ser1101 to alanine renders IRS-1 insensitive to PKCθ and restores insulin signaling. In vitro kinase assay, site-directed mutagenesis (S1101A), IRS-1 phosphorylation and Akt activation assays in cultured cells The Journal of biological chemistry High 15364919
2004 PD-1 engagement inhibits TCR-mediated phosphorylation of ZAP70 and its association with CD3ζ, and attenuates PKCθ activation-loop phosphorylation; the phosphorylated PD-1 ITSM motif acts as a docking site for SHP-2 and SHP-1 in vitro. T cell stimulation with cognate TCR signal + PD-1 ligation, immunoprecipitation, phosphopeptide pull-down assays FEBS letters High 15358536
2005 PKCθ phosphorylates CARMA1 on serine residues within its linker region (S564, S649, S657 per one study; Ser552 per another), converting CARMA1 from an inactive to an active conformer that recruits downstream IKK signalosome components to the immunological synapse, thereby enabling TCR-induced NF-κB activation. Co-IP, in vitro kinase assay, site-directed mutagenesis of CARMA1 serine residues, reconstitution in CARMA1-deficient T cells, lipid raft fractionation Immunity High 16356855 16356856
2010 PKCθ is recruited to the immunological synapse of effector T cells but is sequestered away from the regulatory T cell (Treg) immunological synapse; PKCθ blockade enhances Treg suppressive function, and inhibition of PKCθ protects Tregs from TNF-α-mediated inactivation, including restoration of defective Tregs from rheumatoid arthritis patients. Immunofluorescence microscopy, pharmacological PKCθ inhibitor, Treg suppression assays in vitro and in vivo (colitis model) Science (New York, N.Y.) High 20339032
2011 PRKCQ is a direct transcriptional target of the hematopoietic transcription factor RUNX1 in megakaryocytic cells; RUNX1 binds the PRKCQ promoter at a consensus site (ACCGCA at −1088 to −1069 bp) and positively regulates PKCθ expression; RUNX1 mutation/haplodeficiency reduces PKCθ protein, contributing to impaired platelet function. Chromatin immunoprecipitation (ChIP), electrophoretic mobility shift assay (EMSA), RUNX1 overexpression and siRNA knockdown with promoter-reporter assays Arteriosclerosis, thrombosis, and vascular biology High 21252065
2014 Acute lipid infusion in humans transiently increases cytosolic diacylglycerol (DAG) content, which is temporally associated with PKCθ activation, increased IRS-1 Ser1101 phosphorylation, and inhibition of insulin-stimulated IRS-1 tyrosine phosphorylation and AKT2 phosphorylation, supporting DAG-activated PKCθ as a key mechanism of lipid-induced muscle insulin resistance. Serial muscle biopsies during lipid infusion, DAG and PKCθ activation measurements, IRS-1 and AKT phosphorylation assays; compared in lean, obese, and type 2 diabetic subjects Proceedings of the National Academy of Sciences of the United States of America High 24979806
2016 PRKCQ/PKCθ promotes oncogenic phenotypes in breast epithelial cells: kinase-active (but not kinase-inactive) PKCθ drives Erk/MAPK-dependent Rb phosphorylation and cell-cycle progression under growth-factor-deprived conditions, as well as anchorage-independent survival and migration. Downregulation of PRKCQ in TNBC cells enhances anoikis and impairs xenograft tumor growth. Gain- and loss-of-function (kinase-active/inactive cDNA, shRNA), kinase inhibitor (AEB071), Erk/MAPK and Rb phosphorylation assays, 3D culture, xenograft tumor models Breast cancer research : BCR High 27663795
2020 PRKCQ/PKCθ regulates chemotherapy sensitivity in TNBC cells via kinase-activity-dependent suppression of pro-apoptotic Bim; kinase-active (but not kinase-inactive) PKCθ overexpression suppresses Bim, and PRKCQ inhibition restores Bim expression and enhances apoptosis induced by paclitaxel or doxorubicin. shRNA/cDNA modulation, kinase-inactive mutant, small-molecule PKCθ inhibitor (17k), Bim/Bcl2 family western blot, apoptosis assays Breast cancer research : BCR High 32600444
2021 Prkcq in Schwann cells regulates their proliferation, migration, and apoptosis after sciatic nerve injury, acting through the β-catenin, c-fos, and p-c-jun/c-jun pathways; Prkcq expression decreases during nerve repair, and modulation of its levels alters Wallerian degeneration and regeneration. In vivo rat sciatic nerve injury model, siRNA/overexpression in Schwann cells, pathway analysis (β-catenin, c-fos, c-jun phosphorylation), proliferation and apoptosis assays Experimental neurology Medium 34418453
2023 miR-128-1-5p directly targets the 3'-UTR of PRKCQ mRNA (validated by luciferase assay) to suppress PRKCQ protein, thereby inhibiting colorectal cancer cell proliferation and inducing apoptosis. Luciferase reporter assay, western blot, CCK-8, colony formation, TUNEL, subcutaneous tumor model Cancer biology & therapy Medium 37358216
2025 PRKCQ is dispensable for spermatogenesis and male fertility in mice; Prkcq-/- males generated by CRISPR/Cas9 show no defects in spermatogenic cells, sperm parameters, or sperm motility despite PRKCQ being highly expressed in testis. CRISPR/Cas9 knockout mice, histology, immunofluorescence, computer-assisted sperm analysis, qPCR Cell biology international High 40051302
2025 Prkcq in ILC2 cells regulates expression of IL-4, IL-5, and IL-13; Prkcq knockdown in ILC2s suppresses these cytokines and reduces tissue-resident macrophage (TRM) abundance in chronic pancreatitis, ultimately alleviating pancreatic fibrosis in a mouse model. Single-cell sequencing data analysis, DBTC-induced CP mouse model, Prkcq knockdown in ILC2s, H&E/Masson/Sirius Red staining, ILC2 and TRM quantification Archives of biochemistry and biophysics Medium 40706949
2026 Ganoderma lucidum triterpenoids (GLTs) inhibit adipogenesis via upregulation of PRKCQ in adipocytes; deletion of PRKCQ reverses the anti-adipogenic effect of GLT, identifying PRKCQ as a mediator of the anti-obesity activity of GLTs. High-fat diet mouse model, preadipocyte differentiation assays, Prkcq deletion, adipogenic gene expression (PPARγ, C/EBPα, FASN, SCD-1), network pharmacology Foods (Basel, Switzerland) Medium 41596924

Source papers

Stage 0 corpus · 54 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 1778 24390342
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2009 Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nature genetics 1382 19430480
2002 ERM proteins and merlin: integrators at the cell cortex. Nature reviews. Molecular cell biology 1121 12154370
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2010 Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nature genetics 1018 20453842
2000 PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature 719 10746729
2012 Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell 708 22939624
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2004 PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. FEBS letters 643 15358536
2008 Shared and distinct genetic variants in type 1 diabetes and celiac disease. The New England journal of medicine 566 19073967
2008 Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nature genetics 445 18794853
1997 Selective modulation of protein kinase C-theta during T-cell activation. Nature 445 8985252
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2005 Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proceedings of the National Academy of Sciences of the United States of America 417 15790681
2008 Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nature genetics 415 18978792
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2014 Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans. Proceedings of the National Academy of Sciences of the United States of America 327 24979806
2005 Phosphorylation of the CARMA1 linker controls NF-kappaB activation. Immunity 288 16356855
2004 Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). The Journal of biological chemistry 277 15364919
1997 Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis. The Journal of biological chemistry 267 9252332
1993 Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. The Journal of biological chemistry 261 8444877
2010 Protein kinase C-theta mediates negative feedback on regulatory T cell function. Science (New York, N.Y.) 243 20339032
2005 Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. Immunity 243 16356856
2000 NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta. Proceedings of the National Academy of Sciences of the United States of America 238 10716728
2007 Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy. Nature reviews. Microbiology 232 17632570
1998 Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. The EMBO journal 220 9606192
2016 PRKCQ promotes oncogenic growth and anoikis resistance of a subset of triple-negative breast cancer cells. Breast cancer research : BCR 39 27663795
2020 Long noncoding RNA PRKCQ-AS1 promotes CRC cell proliferation and migration via modulating miR-1287-5p/YBX1 axis. Journal of cellular biochemistry 29 32619070
2020 PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim. Breast cancer research : BCR 28 32600444
2022 Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ. Cytokine 26 35447530
2011 Platelet protein kinase C-theta deficiency with human RUNX1 mutation: PRKCQ is a transcriptional target of RUNX1. Arteriosclerosis, thrombosis, and vascular biology 23 21252065
2023 LncRNA PRKCQ-AS1 regulates paclitaxel resistance in triple-negative breast cancer cells through miR-361-5p/PIK3C3 mediated autophagy. Clinical and experimental pharmacology & physiology 20 36732923
2023 MiR-128-1-5p inhibits cell proliferation and induces cell apoptosis via targeting PRKCQ in colorectal cancer. Cancer biology & therapy 11 37358216
2016 Genetic Variation in the REL Gene Increases Risk of Behcet's Disease in a Chinese Han Population but That of PRKCQ Does Not. PloS one 11 26784953
2023 Fasting regulates mitochondrial function through lncRNA PRKCQ-AS1-mediated IGF2BPs in papillary thyroid carcinoma. Cell death & disease 10 38092752
2025 The Super Enhancer-Driven Long Noncoding RNA PRKCQ-AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8 40103284
1998 Molecular characterization of the human protein kinase C theta gene locus (PRKCQ). Molecular & general genetics : MGG 8 9790596
2022 Role of immune-related lncRNAs--PRKCQ-AS1 and EGOT in the regulation of IL-1β, IL-6 and IL-8 expression in human gingival fibroblasts with TNF-α stimulation. Journal of dental sciences 6 36643260
2019 Missense mutation in PRKCQ is associated with Crohn's disease. Journal of digestive diseases 5 30828974
2016 CD3D and PRKCQ work together to discriminate between B-cell and T-cell acute lymphoblastic leukemia. Computers in biology and medicine 5 27494091
2025 Identification of PRKCQ-AS1 as a Keratinocyte-Derived Exosomal lncRNA That Promotes Th17 Differentiation and IL-17 secretion in Psoriasis Through Bioinformatics, Machine Learning Algorithms, and Cell Experiments. Journal of inflammation research 3 40433053
2025 Clinical significance and biological function of PRKCQ-AS1/miR-582-3p expression in LUAD. Hereditas 3 40597380
2024 DNA methyltransferases-associated long non-coding RNA PRKCQ-AS1 regulate DNA methylation in myelodysplastic syndrome. International journal of laboratory hematology 3 38679027
2021 Protein kinase C theta (Prkcq) affects nerve degeneration and regeneration through the c-fos and c-jun pathways in injured rat sciatic nerves. Experimental neurology 3 34418453
2019 PRKCQ rs4750316 is associated with Vogt-Koyanagi-Harada syndrome in a Han Chinese population. Molecular vision 3 31908401
2025 Association of PRKCQ variants with breast cancer susceptibility and clinicopathological features. BMC cancer 2 40597019
2025 Cancer-associated fibroblast promotes tamoxifen resistance in estrogen receptor positive breast cancer via exosomal LncRNA PRKCQ-AS1/miR-200a-3p/MKP1 axis-mediated apoptosis suppression. Journal of experimental & clinical cancer research : CR 1 41029829
2026 Ganoderma lucidum Triterpenoids Suppress Adipogenesis and Obesity via PRKCQ Activation: An Integrated In Vivo, In Vitro, and Systems Pharmacology Study. Foods (Basel, Switzerland) 0 41596924
2025 PRKCQ Is Dispensable for Spermatogenesis in Mice. Cell biology international 0 40051302
2025 Prkcq in ILC2 cells-enhanced the amounts of tissue-resident macrophages promotes pancreatic fibrosis in chronic pancreatitis. Archives of biochemistry and biophysics 0 40706949